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https://www.readbyqxmd.com/read/28810311/-retrospective-analysis-of-13-cases-of-nocardiosis
#1
H Q Yang, H Z Shi, Z H Tong
Objective: To evaluate the clinical features, chest radiological manifestations, microbiological examination and treatments of nocardial disease. Methods: A retrospective study was conducted to analyze the data of patients with nocardial infection admitted to Beijing Chaoyang Hospital from January 2010 to January 2016. Results: The 13 patients, 6 males and 7 females, aged (51±17) years. Twelve cases were diagnosed with pulmonary nocardiosis, and 1 with disseminated nocardial infection. Most of these patients had complications: autoimmune diseases in 3 (2 with autoimmune hemolytic anemia and 1 with systemic lupus erythematosus), and bronchiectasis in 6 patients...
August 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28809565/dipicolinic-acid-derivatives-as-inhibitors-of-new-delhi-metallo-%C3%AE-lactamase-1
#2
Allie Y Chen, Pei W Thomas, Alesha C Stewart, Alexander Bergstrom, Zishuo Cheng, Callie Miller, Christopher R Bethel, Steven H Marshall, Cy V Credille, Christopher L Riley, Richard C Page, Robert A Bonomo, Michael W Crowder, David L Tierney, Walter Fast, Seth M Cohen
The efficacy of β-lactam antibiotics is threatened by the emergence and global spread of metallo-β-lactamase-(MBL) mediated resistance, specifically New Delhi-Metallo-β- lactamase-1 (NDM-1). Utilizing fragment-based drug discovery (FBDD), a new class of inhibitors for NDM-1 and two related β-lactamases, IMP-1 and VIM-2, was identified. Based on 2,6-dipicolinic acid (DPA), several libraries were synthesized for structure-activity relationship (SAR) analysis. Inhibitor 36 (IC50 = 80 nM) was identified to be highly selective for MBLs when compared to other Zn(II) metalloenzymes...
August 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28807096/a-five-year-surveillance-of-carbapenemase-producing-klebsiella-pneumoniae-in-a-pediatric-hospital-in-china-reveals-increased-predominance-of-ndm-1
#3
Fang Dong, Jie Lu, Yan Wang, Jin Shi, Jing Hui Zhen, Ping Chu, Yang Zhen, Shu Jing Han, Yong Li Guo, Wen Qi Song
OBJECTIVE: To characterize carbapenem (CPM)-non-susceptible Klebsiella pneumoniae (K. pneumoniae) and carbape-nemase produced by these strains isolated from Beijing Children's Hospital based on a five-year surveillance. METHODS: The Minimal Inhibition Concentration values for 15 antibiotics were assessed using the Phonix100 compact system. PCR amplification and DNA sequencing were used to detect genes encoding carbapenemases. WHONET 5.6 was finally used for resistance analysis...
August 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28804554/effect-of-omiganan-on-colonic-anastomosis-healing-in-a-rat-model-of-peritonitis
#4
Teresa Lorenzi, Maria Michela Cappelletti Trombettoni, Roberto Ghiselli, Francesca Paolinelli, Rosaria Gesuita, Oscar Cirioni, Mauro Provinciali, Wojciech Kamysz, Elzbieta Kamysz, Cristiano Piangatelli, Mario Castellucci Md, Mario Guerrieri, Manrico Morroni
BACKGROUND: This study investigates the effects of the antimicrobial cationic peptide omiganan-alone and combined with the antibiotic imipenem-on colonic anastomosis healing in presence of intraperitoneal sepsis induced in a rodent model of cecal ligation and puncture (CLP). METHODS: Forty male Wistar rats were divided into 5 groups of 8 animals. Group 1 (control group) underwent laparotomy and cecal mobilization and the next day received left colon anastomosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28797068/virulence-profiles-and-innate-immune-responses-against-highly-lethal-multidrug-resistant-nosocomial-isolates-of-acinetobacter-baumannii-from-a-tertiary-care-hospital-in-mexico
#5
Roberto Rosales-Reyes, Catalina Gayosso-Vázquez, José Luis Fernández-Vázquez, Ma Dolores Jarillo-Quijada, César Rivera-Benítez, José Ignacio Santos-Preciado, María Dolores Alcántar-Curiel
Virulence profiles and innate immune responses were studied in Acinetobacter baumannii from nosocomial infections collected over one year in a tertiary care hospital in Mexico. A. baumannii were identified by VITEK 2 System followed by susceptibility tests. Carbapenemase genes, active efflux mechanism to imipenem and meropenem and outer membrane proteins profile were analyzed to evaluate their role on the activity of carbapenem resistance. All isolates were genotyped by pulsed field gel electrophoresis. The ability to form biofilm was determined on a polystyrene surface...
2017: PloS One
https://www.readbyqxmd.com/read/28792697/the-first-enterobacter-cloacae-co-producing-ndm-and-oxa-48-carbapenemases-and-interhospital-spread-of-oxa-48-and-ndm-producing-klebsiella-pneumoniae-in-turkey
#6
Demet Haciseyitoglu, Aysegul Dokutan, Ayham Abulaila, Fatma Erdem, Yasemin Cag, Serdar Ozer, Zerrin Aktas
BACKGROUND: The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae. METHODS: A total of 54 carbapenem nonsusceptible Enterobacteriaceae (CRE) isolates were recovered from clinical samples sent to the Dr. Lutfi Kirdar Kartal Training and Research Hospital from the period 2011 through 2014. Forty-four isolates were Klebsiella pneumoniae (CRKP) and the other 10 were Enterobacter cloacae (CREC).The isolate identifications and antibiotic sensitivity tests were performed using a Vitek2 automatic system...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28789605/analysis-of-distribution-and-antibiotic-resistance-of-pathogens-isolated-from-the-paediatric-population-in-shenmu-hospital-from-2011-2015
#7
Yang Hui-Min, Wang Yan-Ping, Yong Lin Liu, Bilal Haider Shamsi, He Bo, Meng Xu-Chun
Objective This study aimed to investigate the epidemiology and changes in antibacterial susceptibility of children in Shenmu City, northern Shaanxi, and provide a basis for rational drug use. Methods The distribution and drug resistance pattern of pathogenic bacteria isolated from children were retrospectively analysed. Results A total of 573 strains of pathogens were cultivated. A total of 201 (35.07%) strains of Gram-positive cocci and 183 (31.93%) strains of Gram-negative cocci were detected. A total of 189 (32...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28763905/-analysis-of-drug-resistance-of-acinetobacter-baumannii-in-wound-of-children-with-traffic-injury-and-its-relationship-with-antibiotic-use
#8
S Liu, C Wang, Y X Fu
Objective: To know the drug resistance of Acinetobacter baumannii (AB) in wound of children with traffic injury and its relationship with antibiotic use. Methods: Wound exudate of 226 children with traffic injury admitted to our unit from January 2010 to December 2015 were collected. API bacteria identification panels and fully automatic microbiological identification system were used to identify pathogens. Kirby-Bauer paper disk diffusion method was used to detect the drug resistance of pathogens to 18 antibiotics including amoxycillin/clavulanic acid, piperacillin/tazobactam, and imipenem...
July 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28762368/antibiotic-susceptibility-profiles-of-non-fermenting-gram-negative-bacilli-at-a-tertiary-care-hospital-in-patiala-india
#9
Udhayvir Singh Grewal, Rupinder Bakshi, Geeta Walia, Parth Rajeshbhai Shah
BACKGROUND: Non-fermenting Gram-negative bacilli (NFGNB) have emerged as a major cause of healthcare-associated infections and are innately resistant to many antibiotics. AIM: The aim of this study was to determine the prevalence of NFGNB isolated from various clinical specimens and evaluate their antimicrobial susceptibility profiles. MATERIALS AND METHODS: This retrospective study was done at our Department of Microbiology from December 2015 to December 2016...
April 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28762308/the-nephroprotective-effect-of-n-acetyl-l-cysteine-and-atorvastatin-against-imipenem-induced-nephrotoxicity
#10
Abeer M Rababa H, Tamara B Hijjawi, Karem H Alzoubi, Saddam Al Demour, Mera A Ababneh
Imipenem has played an important role in the treatment of broad-spectrum bacterial infection. However, nephrotoxicity due to imipenem remains an important clinical challenge. The aim of this study is to test the hypothesis stating that N-acetyl-L-cysteine (NAC) and atorvastatin possess a nephroprotective effect against imipenem-induced nephrotoxicity. Adult Sprague Dawley rats were randomly assigned into six groups (n=8-10 rats/group; total n=55). The groups were (control, imipenem only, NAC only, atorvastatin only, NAC with imipenem, and atorvastatin with imipenem)...
July 31, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28760898/in-vitro-evaluation-of-biofilm-dispersal-as-a-therapeutic-strategy-to-restore-antimicrobial-efficacy
#11
Dan Roizman, Celine Vidaillac, Michael Givskov, Liang Yang
As a proof-of-concept study, the direct impact of biofilm dispersal on the in-vitro efficacy of imipenem and tobramycin was evaluated against three-day-old biofilms of Pseudomonas aeruginosa Arabinose induction of biofilm dispersal via activation of the phosphodiesterase yhjH in P. aeruginosa engineering strain PAO1/p BAD -yhjH resulted in an increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy...
July 31, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28756823/determination-of-carbapenem-resistance-mechanism-in-clinical-isolates-of-pseudomonas-aeruginosa-isolated-from-burn-patients-in-tehran-iran
#12
Akbar Mirsalehian, Davood Kalantar-Neyestanaki, Morovat Taherikalani, Fereshteh Jabalameli, Mohammad Emaneini
Carbapenems are the most important therapeutic options that effect against serious infections caused by multidrug resistant Pseudomonas aeruginosa (MDR-PA) isolates. Carbapenems resistant isolates of P. aeruginosa are increasing worldwide. The aim of this study was to determine the carbapenem resistance mechanisms in clinical P. aeruginosa isolates from burn patients, in Tehran, Iran. A total of 53 non-duplicated isolates of carbapenem-resistant P. aeruginosa were collected from burn patients. The presence of carbapenemase genes were determined by PCR...
September 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28755261/acinetobacter-pittii-an-emerging-new-multi-drug-resistant-fish-pathogen-isolated-from-diseased-blunt-snout-bream-megalobrama-amblycephala-yih-in-china
#13
Jie Li, Jinglong Cao, Xu Wang, Ning Liu, Weimin Wang, Yi Luo
Despite the reason that genus Acinetobacter works as a grave human pathogen, very few numbers of researches have been done so that term it as a pathogen in respect to fish. As per the current study, isolation of three pathogenic bacterial strains was carried out from infected blunt snout bream (Megalobrama amblycephala Yih), from a farm in Yixing city, Jiangsu province, China, which displayed symptoms like tail-rot, shedding scales and ascites in addition to gentle ulceration on the entire body regardless of size and sex of fish...
July 28, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28754148/nosocomial-bacterial-infections-and-their-antimicrobial-susceptibility-patterns-among-patients-in-ugandan-intensive-care-units-a-cross-sectional-study
#14
Peter Agaba, Janat Tumukunde, J V B Tindimwebwa, Arthur Kwizera
BACKGROUND: The intensive care unit (ICU) admits critically ill patients requiring advanced airway, respiratory, cardiac and renal support. Despite the highly-specialized interventions, the mortality and morbidity is still high due to a number of reasons including nosocomial infections, which are the most likely complications in hospitalized patients with the rates being highest among ICU patients. METHODS: In this cross-sectional study of 111 adult patients admitted to 2 of the ICUs in Uganda, we set out to describe the commonest bacterial infections, their antimicrobial susceptibility patterns and factors associated with development of a nosocomial infection...
July 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28751669/in-vivo-loss-of-carbapenem-resistance-by-extensively-drug-resistant-klebsiella-pneumoniae-during-treatment-via-porin-expression-modification
#15
Suzanne Bialek-Davenet, Noémie Mayer, Julia Vergalli, Marion Duprilot, Sylvain Brisse, Jean-Marie Pagès, Marie-Hélène Nicolas-Chanoine
Klebsiella pneumoniae, an Enterobacteriaceae that mostly causes hospital-acquired infections, belongs to the recently published WHO's list of antibiotic-resistant pathogens that pose the greatest threat to human health. Indeed, K. pneumoniae is the enterobacterial species most concerned by both resistance to extended-spectrum cephalosporins, due to extended-spectrum β-lactamase (ESBL) production, and resistance to carbapenems, i.e. the β-lactams with the broadest activity. Carbapenem resistance is related not only to carbapenemase production, but also the production of ESBL or AmpC and the loss of general porins...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28749392/evaluation-of-evidence-for-pharmacokinetics-pharmacodynamics-based-dose-optimization-of-antimicrobials-for-treating-gram-negative-infections-in-neonates
#16
REVIEW
Nusrat Shafiq, Samir Malhotra, Vikas Gautam, Harpreet Kaur, Pravin Kumar, Sourabh Dutta, Pallab Ray, Nilima A Kshirsagar
BACKGROUND & OBJECTIVES: Neonates present a special subgroup of population in whom optimization of antimicrobial dosing can be particularly challenging. Gram-negative infections are common in neonates, and inpatient treatment along with critical care is needed for the management of these infections. Dosing recommendations are often extrapolated from evidence generated in older patient populations. This systematic review was done to identify the knowledge gaps in the pharmacokinetics-pharmacodynamics (PK-PD)-based optimized dosing schedule for parenteral antimicrobials for Gram-negative neonatal infections...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28743649/first-report-of-blaoxa-181-mediated-carbapenem-resistance-in-aeromonas-caviae-in-association-with-pkp3-a-threat-for-rapid-dissemination
#17
Shalini Anandan, Radha Gopi, Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Priya Gunasekaran, Kamini Walia, Balaji Veeraraghavan
OBJECTIVES: Aeromonas spp producing carbapenemases is of great concern in health-care settings and also known to acquire clinically relevant resistance genes. In this study, carbapenem non-susceptible Aeromonas isolates were characterized for their molecular mechanism. METHOD: Out of 180 Aeromonas isolates, 10 carbapenem non-susceptible isolates were selected based on their antimicrobial susceptibility profile. Carbapenemase production was investigated using CarbaNP method...
July 22, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28743282/a-hospital-based-surveillance-of-metallo-beta-lactamase-producing-gram-negative-bacteria-in-nepal-by-imipenem-edta-disk-method
#18
Pratigya Thapa, Dinesh Bhandari, Dhiraj Shrestha, Hiramani Parajuli, Prakash Chaudhary, Jyoti Amatya, Ritu Amatya
BACKGROUND: A rising threat of the rapid spread of acquired metallo-beta-lactamases (MBLs) among major Gram-negative pathogens is a matter of public health concern worldwide. Hence, for a low income nation like Nepal, surveillance data on MBL producing clinical isolates via a cost effective technique is necessary to prevent their dissemination as well as formulation and regulation of antimicrobial stewardship policy. METHODS: The prospective study was conducted at Nepal Medical College, Kathmandu from May to October, 2014 to assess the prevalence of MBL production among ceftazidime-resistant Gram-negative rods (GNRs) isolates...
July 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28739428/novel-class-1-integrons-and-sequence-types-in-vim-2-and-vim-11-producing-clinical-strains-of-enterobacter-cloacae
#19
D De Belder, D Faccone, N Tijet, R G Melano, M Rapoport, A Petroni, C Lucero, F Pasteran, A Corso, S A Gomez
All VIM-producing Enterobacteriaceae (six Enterobacter cloacae) submitted to the Argentinian Reference Laboratory in Antimicrobial Resistance in the period 2008-13 were characterized. The isolates were referred from 6 nosocomial institutions located in 5 different cities across the country. All isolates showed carbapenem disk diffusion inhibition zones ≤22mm and synergism between a carbapenem disk and EDTA/SMA. The six isolates were PCR positive for blaVIM. Imipenem MICs were ≤1 to 8μg/ml. Typing by PFGE and MLST distinguished six pulsotypes and sequence types with blaVIM located on novel class 1 integron arrays: ECL-1: ST182, In883; ECL-2, ST90, In885; ECL-3, ST88, In346 with blaVIM-11; ECL-4, ST184, In900; ECL-5, ST749-new, In900; ECL-6, ST91 and uncharacterized In...
July 21, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28737463/prevalence-of-a-new-variant-oxa-204-and-oxa-48-carbapenemases-plasmids-encoded-in-klebsiella-pneumoniae-clinical-isolates-in-tunisia
#20
Rym Ouertani, Mariem Ben Jomàa-Jemili, Haythem Gharsa, Anne Limelette, Thomas Guillard, Lucien Brasme, Christophe de Champs, Chedly Chouchani
Carbapenemase-producing Klebsiella pneumoniae strains have emerged as a major problem for healthcare systems. The aim of this study was to determine the role and diversity of plasmids harboring carbapenemases encoding genes from a collection of K. pneumoniae isolates recovered between July 2011 and January 2012, with decreased susceptibility to carbapenems. Imipenem (IPM), ertapenem (ETP), meropenem (MEM), and doripenem (DOR) minimum inhibitory concentrations (MICs) were determined by E-test. Carbapenemase production was detected with the modified Hodge test...
July 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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