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https://www.readbyqxmd.com/read/29351806/isolated-septic-arthritis-of-hip-joint-a-rare-presentation-of-melioidosis-a-case-report
#1
N P Weerasinghe, H M M Herath, T M U Liyanage
BACKGROUND: Despite, Sri Lanka lies in the melioidosis endemic belt between 5°N and 10°N surrounded by countries known to have endemic melioidosis for many years, comparatively fewer cases of melioidosis infection have been reported in Sri Lanka. Melioidosis has a wide spectrum of clinical presentation, ranging from severe pneumonia to abscess formation in various organs. Isolated septic arthritis, which is a rare but well-recognized manifestation of melioidosis, could be the sole presenting problem in some patients with melioidosis...
January 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29348071/a-focused-fragment-library-targeting-the-antibiotic-resistance-enzyme-oxacillinase-48-synthesis-structural-evaluation-and-inhibitor-design
#2
Sundus Akhter, Bjarte Aarmo Lund, Aya Ismael, Manuel Langer, Johan Isaksson, Tony Christopeit, Hanna-Kirsti S Leiros, Annette Bayer
β-Lactam antibiotics are of utmost importance when treating bacterial infections in the medical community. However, currently their utility is threatened by the emergence and spread of β-lactam resistance. The most prevalent resistance mechanism to β-lactam antibiotics is expression of β-lactamase enzymes. One way to overcome resistance caused by β-lactamases, is the development of β-lactamase inhibitors and today several β-lactamase inhibitors e.g. avibactam, are approved in the clinic. Our focus is the oxacillinase-48 (OXA-48), an enzyme reported to spread rapidly across the world and commonly identified in Escherichia coli and Klebsiella pneumoniae...
December 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29341954/carbapenemase-production-of-clinical-isolates-acinetobacter-baumannii-and-pseudomonas-aeruginosa-from-a-bulgarian-university-hospital
#3
Atanaska P Petrova, Irina D Stanimirova, Ivan N Ivanov, Michael M Petrov, Tsonka M Miteva-Katrandzhieva, Vasil I Grivnev, Velichka S Kardjeva, Todor V Kantardzhiev, Mariana A Murdjeva
BACKGROUND: Production of Bla OXA-23, OXA-24, OXA-58 and hyperexpression of OXA-51 due to ISAba1 insertion sequence are the leading causes of carbapenem resistance in Acinetobacter baumannii. The loss of OprD transmembrane protein and the overexpression of some effl ux pumps are considered to be the main factors for carbapenem resistance in Pseudomonas aeruginosa whereas metallo-enzymes' production has a secondary role. AIM: Тo examine the carbapenem resistance due to carbapenemase production among clinically signifi cant Gram-negative non-fermenters from St George University hospital, Plovdiv: A...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29339388/combating-carbapenem-resistant-acinetobacter-baumannii-by-an-optimized-imipenem-plus-tobramycin-dosage-regimen-prospective-validation-via-hollow-fiber-infection-and-mathematical-modeling
#4
Cornelia B Landersdorfer, Rajbharan Yadav, Kate E Rogers, Tae Hwan Kim, Beom Soo Shin, John D Boyce, Roger L Nation, Jürgen B Bulitta
We aimed to prospectively validate an optimized combination dosage regimen against a clinical carbapenem-resistant Acinetobacter baumannii (CRAB; MICImipenem: 32mg/liter, MICTobramycin: 2mg/liter). Imipenem at constant concentrations (7.6, 13.4 and 23.3mg/liter, reflecting a range of clearances) was simulated in a 7-day hollow fiber infection model (inoculum ∼107.2 CFU/mL) with and without tobramycin (7mg/kg q24h, 0.5h infusions). While monotherapies achieved no killing or failed by 24h, this rationally optimized combination achieved >5 log10 bacterial killing and suppressed resistance...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29337703/new-antibiotics-for-ventilator-associated-pneumonia
#5
Matteo Bassetti, Antionio Vena, Nadia Castaldo, Elda Righi, Maddalena Peghin
PURPOSE OF REVIEW: Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) bacteria represents a global emerging problem. Delayed prescription of an adequate treatment for VAP has been associated with higher morbidity and mortality. New molecules have been developed to face the need of compounds that are active against resistant Gram-positive and Gram-negative pathogens. The aim of this review is to summarize the current scenario of new therapeutic options for the treatment of VAP...
January 13, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29326536/first-time-isolation-of-mycobacterium-hassiacum-from-a-respiratory-sample
#6
Stefanie Deinhardt-Emmer, Steffen Höring, Christian Mura, Doris Hillemann, Beate Hermann, Svea Sachse, Jürgen Bohnert, Bettina Löffler
We describe the first isolation of Mycobacterium hassiacum, a rapid-growing, partial acid-resistant mycobacterium, in a respiratory specimen from a patient with exacerbated chronic obstructive pulmonary disease. To provide therapeutic recommendation for future cases, antibiotic susceptibility testing of 3 clinical isolates was performed by broth microdilution. All strains tested showed susceptibility to clarithromycin, imipenem, ciprofloxacin, and doxycycline. The role of M hassiacum as a respiratory pathogen remains unclear and needs to be evaluated by future reports...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/29323530/prevalence-and-molecular-characterization-of-antimicrobial-resistance-in-escherichia-coli-isolated-from-raw-milk-and-raw-milk-cheese-in-egypt
#7
Rabee A Ombarak, Atsushi Hinenoya, Abdel-Rahman M Elbagory, Shinji Yamasaki
The goal of this study was to examine antimicrobial resistance and characterize the implicated genes in 222 isolates of Escherichia coli from 187 samples of raw milk and the two most popular cheeses in Egypt. E. coli isolates were tested for susceptibility to 12 antimicrobials by a disk diffusion method. Among the 222 E. coli isolates, 66 (29.7%) were resistant to one or more antimicrobials, and half of these resistant isolates showed a multidrug resistance phenotype (resistance to at least three different drug classes)...
January 11, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29323070/is-diabetes-mellitus-an-important-risk-factor-for-the-antibiotic-resistance-in-extraintestinal-pathogenic-escherichia-coli
#8
Arindam Chakraborty, Shalini Shenoy, Prabha Adhikari, Vishwas Saralaya, Satish Rao
Escherichia coli is a major cause of extraintestinal infections in all age group. However, the infection becomes more severe when patients have some underlying condition such as Diabetes Mellitus. The aim of the study was to determine whether diabetic mellitus may act as an important risk factor for the E. coli to express drug resistance property. This descriptive study was carried out in a multi-specialty tertiary care hospital. One hundred and twenty-seven E. coli isolates from diabetic patients, and one hundred seventy-three isolates from nondiabetic patients were studied...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29311084/intrapulmonary-pharmacokinetics-of-relebactam-a-novel-%C3%AE-lactamase-inhibitor-dosed-in-combination-with-imipenem-cilastatin-in-healthy-subjects
#9
Matthew L Rizk, Elizabeth G Rhee, Patricia A Jumes, Mark H Gotfried, Tian Zhao, Eric Mangin, Sheng Bi, Cynthia M Chavez-Eng, Zufei Zhang, Joan R Butterton
This Phase I study assessed the intrapulmonary pharmacokinetic profiles of relebactam (MK-7655), a novel ß-lactamase inhibitor, and imipenem. Sixteen healthy subjects received 250 mg relebactam with 500 mg imipenem/cilastatin, given IV every 6 hours for 5 doses, and were randomized to bronchoscopy/broncho-alveolar lavage at 0.5, 1, 1.5, or 3 hours after the last dose (4 subjects per time point). Both drugs penetrated the epithelial lining fluid (ELF) to a similar degree, with profiles similar in shape to the corresponding plasma profiles and apparent terminal half-lives in plasma and ELF, respectively, of 1...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310404/extracorporeal-membrane-oxygenation-combined-with-continuous-renal-replacement-therapy-in-cutaneous-burn-and-inhalation-injury-caused-by-hydrofluoric-acid-and-nitric-acid
#10
Qinhua Pu, Jinxian Qian, Weiyi Tao, Aixiang Yang, Jian Wu, Yaodong Wang
RATIONALE: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. PATIENT CONCERNS: A 25-year-old man fell into an electroplating pool containing 10% HF and 50% nitric acid...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29310399/blaoxa-23-like-and-blatem-rather-than-blaoxa-51-like-contributed-to-a-high-level-of-carbapenem-resistance-in-acinetobacter-baumannii-strains-from-a-teaching-hospital-in-xi-an-china
#11
Lei Han, Jine Lei, Jiru Xu, Shaoshan Han
Acinetobacter baumannii is one of the major threats in clinical infections due to its antibiotic resistance ability. It shows increasing resistance to carbapenems, mainly due to β-lactamase mediated mechanisms. The aim of this study was to investigate carbapenem resistance (CR) profiles and analyze β-lactamases genes composition of clinical A. baumannii strains from a teaching hospital in Xi'an. The resistance patterns to imipenem and meropenem were checked for 51 clinical A. baumannii strains. The existence of 15 β-lactamases genes was detected by polymerase chain reaction (PCR), and the positive genes were sequenced...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307737/detection-of-carbapenemase-activity-in-pseudomonas-aeruginosa-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms
#12
G Miltgen, P Plésiat, A Mille, P Chatelain, D Fournier
A new MALDI-TOF MS imipenem hydrolysis assay was developed to optimize detection of carbapenemase-producing strains of Pseudomonas aeruginosa. The method correctly discriminated carbapenemase producers (n=74) from non-producers (n=95) in 99.4% of cases, and successfully detected 100% GES-5 strains (n=5).
January 4, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29303020/risk-factors-outcomes-and-genotypes-of-carbapenem-nonsusceptible-klebsiella-pneumoniae-bloodstream-infection-a-three-year-retrospective-study-in-a-large-tertiary-hospital-in-northern-china
#13
Si-Han Zheng, Sheng-Ji Cao, Hui Xu, Dan Feng, Li-Ping Wan, Guang-Jie Wang, Xiao-Guang Xiao
OBJECTIVE: To investigate the independent risk factors, outcomes and genotypes associated with carbapenem-non-susceptible K. pneumoniae bloodstream infections (BSIs) in northern China from 2014 to 2016. METHODS: Over a three-year period, a total of 289 K. pneumoniae BSI patients were identified. Medical records were extracted to obtain the clinical information. Polymerase chain reactions (PCRs) were performed to analyse the multilocus sequence typing (MLST) types, Klebsiella pneumoniae carbapenemase (KPC) and metallo-β-lactamases (MBL) genes, for replicon typing of the 10 randomly selected carbapenem-non-susceptible K...
January 5, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29302147/current-trends-of-drug-resistance-patterns-of-acinetobacter-baumannii-infection-in-blood-transfusion-dependent-thalassemia-patients
#14
Suhail Ahmed Almani, Ali Naseer, Sanjay Kumar Maheshwari, Pir Maroof, Raza Naseer, Haji Khan Khoharo
Objective: The present study aimed to evaluate the current trends of drug resistance patterns of Acinetobacter baumannii infection in blood transfusion-dependent thalassemia patients. Study Design: This study was a cross sectional study, conducted at the Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad, Sindh, Pakistan from October 2014 to January 2016. Subjects and Methods: Of 921 blood samples, A. baumannii strains were isolated from 100 blood samples...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29298123/molecular-characterization-of-pseudomonas-putida-group-isolates-carrying-blavim-2-disseminated-in-a-university-hospital-in-korea
#15
Jun Sung Hong, Eun-Jeong Yoon, Wonkeun Song, Yu Bin Seo, Saeam Shin, Min-Jeong Park, Seok Hoon Jeong, Kyungwon Lee
Pseudomonas putida group are Gram-negative bacilli with polar flagellation, which are ubiquitous in the environment, although they are rarely involved in human infections. The aim of this study was to identify the dissemination of VIM-2-producing P. putida group in clinical isolates from a hospital in Korea. Thirteen strains were collected from 2014 to 2015 for the study. The isolates were recovered from urine cultures of both inpatients and outpatients at the hospital. Minimum inhibitory concentrations of antibiotics were determined by Etest...
January 3, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29296273/new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates-in-hospitalized-patients-in-kashan-iran
#16
Farzaneh Firoozeh, Zeinab Mahluji, Ehsaneh Shams, Ahmad Khorshidi, Mohammad Zibaei
Background and Objectives: New Delhi metallo-ß-lactamase (NDM) is a newly emerging metallo-ß-lactamases, which can destroy all β-lactams including carbapenems. Therefore, this study aimed at evaluating New Delhi metallo-ß-lactamase-1-production in clinical isolates of Klebsiella pneumoniae in Kashan, Iran. Materials and Methods: In a cross-sectional study, 181 K. pneumoniae isolates were collected from clinical samples of patients, who referred to Shahid Beheshi hospital in Kashan during November 2013 and October 2014...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29285477/pseudomonas-aeruginosa-producing-metallo-%C3%AE-lactamases-vim-imp-sme-and-aim-in-the-clinical-isolates-of-intensive-care-units-a-university-hospital-in-isfahan-iran
#17
Farzin Khorvash, Mohammadreza Yazdani, Shiva Shabani, Aliasghar Soudi
Background: Pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, due to the chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. We undertook this study to evaluate the existence of SME, IMP, AIM, and VIM metallo-β-lactamases (MBL) encoding genes among P. aeruginosa strains isolated from Intensive Care Unit (ICU) patients in Al-Zahra Hospital in Isfahan, Iran. Materials and Methods: In a retrospective cross-sectional study that was conducted between March 2012 and April 2013, a total of 48 strains of P...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29279590/distribution-of-adeb-and-ndm-1-genes-in-multidrug-resistant-acinetobacter-baumannii-isolated-from-infected-wound-of-patients-admitted-in-a-tertiary-care-hospital-in-bangladesh
#18
M J Hasan, S M Shamsuzzaman
BACKGROUND: The adeB gene in Acinetobacter baumannii regulates the bacterial internal drug efflux pump that plays a significant role in drug resistance. The aim of our study was to determine the occurrence of adeB gene in multidrug resistant and New Delhi metallo-beta-lactamase-1 (NDM- 1) gene in imipenem resistant Acinetobacter baumannii isolated from wound swab samples in a tertiary care hospital of Bangladesh. METHODS: A total of 345 wound swab samples were tested for bacterial pathogens...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279444/detection-of-escherichia-coli-producing-ctx-m-1-group-extended-spectrum-%C3%AE-lactamases-from-pigs-in-aichi-prefecture-japan-between-2015-and-2016
#19
Chihiro Norizuki, Kumiko Kawamura, Jun-Ichi Wachino, Masahiro Suzuki, Noriyuki Nagano, Takaaki Kondo, Yoshichika Arakawa
We investigated the prevalence and characteristics of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates from Japanese pigs. A total of 345 pig fecal specimens were collected from 30 farms in Aichi prefecture, Japan, between June 2015 and April 2016, and 22 unique ESBL-producing E. coli were isolated from 16 samples of eight farms. The ESBL types included CTX-M-15 (54.5%), CTX-M-55 (27.2%), CTX-M-3 (0.9%), and CTX-M-14 (0.9%). The predominant plasmid replicon type was IncN, and they carried blaCTX-M-55...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29275225/the-efflux-pump-inhibitor-phenylalanine-arginine-beta-naphthylamide-pa%C3%AE-n-increases-the-resistance-to-carbapenems-in-chilean-clinical-isolates-of-kpc-producing-k-pneumoniae
#20
Alejandra Vera-Leiva, Sergio Carrasco-Anabalón, Celia A Lima, Nicolás Villagra, Mariana Domínguez, Helia Bello-Toledo, Gerardo González-Rocha
OBJECTIVES: KPC-producing strains present a wide range of MICs of carbapenems; this variation may be due to different gene expression levels of the blaKPC and porin genes, associated with efflux-pumps and the production of ESBLs and/or AmpC β-lactamase. The aim of this study was to determine the role of efflux-pumps inhibited by PAβN in the resistance to carbapenems in Chilean clinical isolates of K. pneumoniae harbouring the gene blaKPC. METHODS: Minimum Inhibitory Concentration (MIC) was determined by the agar dilution method for imipenem, meropenem, ertapenem and ciprofloxacin in the presence and absence of PAβN (25mg/L)...
December 21, 2017: Journal of Global Antimicrobial Resistance
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