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https://www.readbyqxmd.com/read/28431099/effect-of-cold-water-induced-stress-on-immune-response-pathology-and-fertility-in-mice-during-chlamydia-muridarum-genital-infection
#1
Tesfaye Belay, Anthony Woart, Vincent Graffeo
Genital infection by Chlamydia trachomatis (CT) is the most common bacterial sexually-transmitted disease worldwide. It causes serious reproductive health complications, including pelvic inflammatory disease and infertility. Stress is implicated as a risk factor for various infections; however, its effect on chlamydia genital infection is unknown. We previously showed that repeated exposure of mice to cold water results in increased severity of chlamydia genital infection. In the present study, cold water-induced stress resulted in: i) elevated levels of NE and EP in the spleen and genital tract of stressed mice; ii) elevated IL-1β, TNF-α, IL-6 and NO production in macrophage-rich peritoneal cells of mice; iii) supplement of NE in vitro exerts an immunosuppressive effect on splenic T cell production of cytokines; iv) decreased C...
April 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#2
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28427542/recurrent-respiratory-papillomatosis-a-state-of-the-art-review
#3
REVIEW
Helena Ribeiro Fortes, Felipe Mussi von Ranke, Dante Luiz Escuissato, Cesar Augusto Araujo Neto, Gláucia Zanetti, Bruno Hochhegger, Carolina Althoff Souza, Edson Marchiori
Recurrent respiratory papillomatosis (RRP) is a benign disease of the upper aero-digestive tract caused by human papillomavirus (HPV) infection, which affects children and young adults. The aim of this review is to describe the main etiological, epidemiological, clinical, diagnostic, and treatment aspects of RRP. Most infections in children occur at birth, during passage through the birth canals of contaminated mothers. In adults, HPV is transmitted sexually. Papillomas usually appear as exophytic nodules, primarily in the larynx, but occasionally involving the nasopharynx, tracheobronchial tree, and pulmonary parenchyma...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28426312/safe-sex-in-the-1970s-community-practitioners-on-the-eve-of-aids
#4
Thomas R Blair
In the 1970s, groups of gay and gay-allied health professionals began to formulate guidelines for safer sexual activity, several years before HIV/AIDS. Through such organizations as the National Coalition of Gay Sexually Transmitted Disease Services, Bay Area Physicians for Human Rights, and the Sisters of Perpetual Indulgence, these practitioners developed materials that would define sexual health education for the next four decades, as well as such concepts as "bodily fluids" and the "safe sex hanky." To do so, they used their dual membership in the community and the health professions...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28425904/-testing-is-healthy-timeplay-campaign-evaluation-of-sexual-health-promotion-gamification-intervention-targeting-young-adults
#5
Qinya Zhang, Kim J Huhn, Andy Tan, Rachel E Douglas, Helen Guiyun Li, Michelle Murti, Victoria Lee
OBJECTIVES: The objectives of the study were to 1) describe the implementation of the "Testing is Healthy" campaign in four locations in British Columbia (BC) and 2) report process evaluation indicators for the campaign. PARTICIPANTS: Young adults ages 20-29 years, the age group with the highest reported rates of chlamydia and gonorrhea in BC. SETTINGS: Movie theatres located in Langley, Burnaby, Coquitlam and Surrey, which are communities served by the Fraser Health Authority (FHA) in BC...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28425301/development-of-a-novel-rationally-designed-antibiotic-to-inhibit-a-nontraditional-bacterial-target
#6
Pavel Dibrov, Elena Dibrov, Thane G Maddaford, Melissa Kenneth, Jordan Nelson, Craig Resch, Grant N Pierce
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na(+)-translocating NADH:ubiquinone oxidoreductase (Na(+)-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. Infection by Chlamydia trachomatis significantly increased first H(+) and then Na(+) levels within the host mammalian cell...
April 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28424832/setting-up-a-community-based-cervical-screening-service-in-a-low-income-country-a-pilot-study-from-north-western-tanzania
#7
Nestory Masalu, Patrizia Serra, Dino Amadori, Jackson Kahima, Charles Majinge, Joyce Rwehabura, Oriana Nanni, Sara Bravaccini, Maurizio Puccetti, Rosario Tumino, Lauro Bucchi
OBJECTIVES: To report the results of a pilot study for a service for cervical cancer screening and diagnosis in north-western Tanzania. METHODS: The pilot study was launched in 2012 after a community-level information campaign. Women aged 15-64 years were encouraged to attend the district health centres. Attendees were offered a conventional Pap smear and a visual inspection of the cervix with acetic acid (VIA). RESULTS: The first 2500 women were evaluated...
April 19, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28424280/the-major-envelope-glycoprotein-of-murid-herpesvirus-4-promotes-sexual-transmission
#8
Caroline Zeippen, Justine Javaux, Xue Xiao, Marina Ledecq, Jan Mast, Frédéric Farnir, Alain Vanderplasschen, Philip Stevenson, Laurent Gillet
Gammaherpesviruses are important human and animal pathogens. Infection control has proved difficult because the key process of transmission is ill-understood. Murid herpesvirus-4 (MuHV-4), a gammaherpesvirus of mice, transmits sexually. We show that this depends on the major virion envelope glycoprotein, gp150. Gp150 is redundant for host entry and, in vitro, it regulates rather than promotes cell binding. We show that gp150-deficient MuHV-4 reaches and replicates normally in the female genital tract after nasal infection, but is poorly released from vaginal epithelial cells and fails to pass from the female to the male genital tract during sexual contact...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28420907/effectiveness-of-health-education-programme-level-of-knowledge-about-prevention-of-cervical-cancer-among-saudi-female-healthcare-students
#9
Ghadeer Khaled Al-Shaikh, Sadiqa Badar Syed, Amel Ahmed Fayed, Reem Ali Al-Shaikh, Eman Mohammed Al-Mussaed, Farida Habib Khan, Hala Nasser Elmorshedy
OBJECTIVE: To evaluate the effectiveness of health education programme on the knowledge of human papilloma virus among female medical students. METHODS: This quasi-experimental study was conducted in 2014 at the Princess Nourah bint Abulrahman University, Riyadh, Saudi Arabia, and comprised female medical students. An intervention programme was implemented in the form of lectures, videos, posters, etc. on human papillomavirus. SPSS 20 was used for data analysis...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28414664/gonococcal-endocarditis-the-gift-that-stops-giving-an-uncommon-presentation-of-a-common-disease
#10
G Olayemi, M Oferczak, A Elagizi, I El-Abbassi, M Eschete, J Crowe
INTRODUCTION: Gonorrhea is the 2nd most common sexually transmitted disease in the US with 800,000 cases of gonorrhea each year. Disseminated gonorrhea infection occurs in 0.5 percent - 3 percent of these patients and is more frequent in woman younger than 40 years of age. CASE: A 36 year old woman with a history of polysubstance abuse presented with 10 day history of feeling generally unwell. At presentation, vitals were remarkable for tachycardia and hypotension...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413133/vaccination-with-the-polymorphic-membrane-protein-a-reduces-chlamydia-muridarum-induced-genital-tract-pathology
#11
Tina Müller, Elisabeth Becker, Sonja Stallmann, Anna Waldhuber, Franziska Römmler-Dreher, Simone Albrecht, Fabian Mohr, Johannes H Hegemann, Thomas Miethke
Chlamydia trachomatis serovars D-K are one of the most frequent causes of sexually transmitted infections of the female genital tract, with possible complications such as hydrosalpinx, pelvic inflammatory disease, extra-uterine gravidity or infertility. We used the murine genital tract infection model with C. muridarum for vaccination studies and found that more than 70% of the infected mice suffered from uterus dilatations and/or hydrosalpinx. Systemic consequences of the vaginal infection were apparent by splenomegaly ten to fifteen days post infection...
April 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28412676/investigation-of-sub-health-status-of-neonates-in-heping-street-region-beijing-and-analysis-on-related-risk-factors
#12
Chen Jie, Shi Mai, Li Qiuju, Ye Fang, Liu Fang, Fan Qinying, Zhang Yong, Wang Lin
To investigate sub-health status of neonates in Heping Street Region and related risk factors. Then, 7436 maternal women admitted to hospital in Heping Street Region, Beijing were enrolled from October 2013 to September 2015, including 293 women, who gave birth to sub-health neonates. Questionnaire survey was conducted to collect maternal age, education degree, experiences and income, occupation, life habit, condition in pregnancy, condition in perinatal period, adverse reaction in pregnancy, etc. Finally, 281 effective questionnaires were regained with effective regain rate of 95...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28410582/metronidazole-for-the-treatment-of-tritrichomonas-foetus-in-bulls
#13
David Love, Virginia R Fajt, Thomas Hairgrove, Meredyth Jones, James A Thompson
BACKGROUND: Tritrichomonas foetus is a sexually transmitted protozoon that causes reproductive failure, among cattle, so disruptive that many western US states have initiated control programs. Current control programs are based on the testing and exclusion of individual bulls. Unfortunately, these programs are utilizing screening tests that are lacking in sensitivity. Blanket treatment of all the exposed bulls and adequate sexual rest for the exposed cows could provide a more viable disease control option...
April 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28410349/zika-virus-and-assisted-reproduction
#14
Christina N Cordeiro, Rashda Bano, Chantel I Washington Cross, James H Segars
PURPOSE OF REVIEW: Due to the fact that the Zika virus can be sexually transmitted, there is a potential risk for disease transmission at several stages of assisted reproduction. Such a possibility poses a serious challenge to couples pursing fertility with reproductive technologies. Here, we discuss what is known regarding Zika virus infection with respect to sexual transmission and correlate this knowledge with recent recommendations in the realm of infertility treatment. RECENT FINDINGS: Zika virus can be transmitted from infected men and women through vaginal, oral or anal intercourse...
April 12, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28409618/zika-virus-common-questions-and-answers
#15
Irogue I Igbinosa, Ingrid B Rabe, Titilope Oduyebo, Sonja A Rasmussen
Since local mosquito-borne transmission of Zika virus was first reported in Brazil in early 2015, the virus has spread rapidly, with active transmission reported in at least 61 countries and territories worldwide, including the United States. Zika virus infection during pregnancy is a cause of microcephaly and other severe brain anomalies. The virus is transmitted primarily through the bite of an infected Aedes mosquito, but other routes of transmission include sexual, mother-to-fetus during pregnancy, mother-to-infant at delivery, laboratory exposure, and, possibly, transfusion of blood products...
April 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28407650/insurance-coverage-and-utilization-at-a-sexually-transmitted-disease-clinic-in-a-medicaid-expansion-state
#16
Madeline C Montgomery, Julia Raifman, Amy S Nunn, Thomas Bertrand, A Ziggy Uvin, Theodore Marak, Jaime Comella, Alexi Almonte, Philip A Chan
BACKGROUND: In Rhode Island, the Patient Protection and Affordable Care Act has led to over 95% of the state's population being insured. We evaluated insurance coverage and barriers to insurance use among patients presenting for services at the Rhode Island sexually transmitted disease (STD) clinic. METHODS: We analyzed factors associated with insurance coverage and utilization among patients presenting for STD services between July and December 2015. RESULTS: A total of 692 patients had insurance information available; of those, 40% were uninsured...
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28406929/hiv-aids-knowledge-attitudes-and-behaviour-of-persons-with-and-without-disabilities-from-the-uganda-demographic-and-health-survey-2011-differential-access-to-hiv-aids-information-and-services
#17
Julie Abimanyi-Ochom, Hasheem Mannan, Nora Ellen Groce, Joanne McVeigh
Uganda is among the first to use the Washington Group Short Set of Questions on Disability to identify persons with disabilities in its Demographic and Health Survey. In this paper, we review the HIV Knowledge, Attitudes and Behaviour component of the 2011 Ugandan Demographic and Health Survey, analysing a series of questions comparing those with and without disabilities in relation to HIV/AIDS knowledge, attitudes and practices. We found comparable levels of knowledge on HIV/AIDS for those with and those without disabilities in relation to HIV transmission during delivery (93...
2017: PloS One
https://www.readbyqxmd.com/read/28406807/community-level-hiv-stigma-as-a-driver-for-hiv-transmission-risk-behaviors-and-sexually-transmitted-diseases-in-sierra-leone-a-population-based-study
#18
J Daniel Kelly, Michael J Reid, Maureen Lahiff, Alexander C Tsai, Sheri D Weiser
INTRODUCTION: While HIV stigma has been identified as an important risk factor for HIV transmission risk behaviors, little is known about the contribution of community-level HIV stigma to HIV transmission risk behaviors and self-reported sexually transmitted diseases (STDs), or how gender may modify associations. METHODS: We pooled data from the 2008 and 2013 Sierra Leone DHS. For HIV stigma, we examined HIV stigmatizing attitudes and HIV disclosure concerns at both individual and community levels...
April 12, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28404357/the-safety-and-immunogenicity-of-quadrivalent-hpv-qhpv-vaccine-in-systemic-lupus-erythematosus
#19
J Patricia Dhar, Lynnette Essenmacher, Renee Dhar, Ardella Magee, Joel Ager, Robert J Sokol
OBJECTIVE: This study evaluated the safety and immunogenicity of qHPV vaccine in SLE. METHODS: Subjects: 34 women ages 19-50years (yrs.) with mild to moderate SLE & minimally active or inactive SLE received qHPV vaccine at the standard dosing schedule. EXCLUSION CRITERIA: active SLE disease (SELENA-SLEDAI>2), history of severe SLE disease, deep venous thrombosis, on >400mg/day of hydroxychloroquine, on >15mg/day of prednisone, or active infections...
April 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28399813/the-netherlands-chlamydia-cohort-study-neccst-protocol-to-assess-the-risk-of-late-complications-following-chlamydia-trachomatis-infection-in-women
#20
B M Hoenderboom, A A M van Oeffelen, B H B van Benthem, J E A M van Bergen, N H T M Dukers-Muijrers, H M Götz, C J P A Hoebe, A A Hogewoning, F R M van der Klis, D van Baarle, J A Land, M A B van der Sande, M G van Veen, F de Vries, S A Morré, I V F van den Broek
BACKGROUND: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI) among young women, can result in serious sequelae. Although the course of infection is often asymptomatic, CT may cause pelvic inflammatory disease (PID), leading to severe complications, such as prolonged time to pregnancy, ectopic pregnancy, and tubal factor subfertility. The risk of and risk factors for complications following CT-infection have not been assessed in a long-term prospective cohort study, the preferred design to define infections and complications adequately...
April 11, 2017: BMC Infectious Diseases
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