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https://www.readbyqxmd.com/read/27923418/outbreak-of-klebsiella-pneumoniae-carbapenemase-producing-citrobacter-freundii-at-a-tertiary-acute-care-facility-in-miami-florida
#1
Adriana Jiménez, José G Castro, L Silvia Munoz-Price, Dennise de Pascale, Luis Shimose, Mustapha M Mustapha, Caressa N Spychala, Roberta T Mettus, Vaughn S Cooper, Yohei Doi
OBJECTIVE To describe the investigation and control of a rare cluster of Klebsiella pneumoniae carbapenemase-producing Citrobacter freundii in a hospital in southern Florida. METHODS An epidemiologic investigation, review of infection prevention procedures, and molecular studies including whole genome sequencing were conducted. RESULTS An outbreak of K. pneumoniae carbapenemase-3-producing C. freundii was identified at a tertiary hospital in Florida in 2014. Of the 6 cases identified, 3 occurred in the same intensive care unit and were caused by the same clone...
December 7, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27866488/disposable-bronchoscope-model-for-simulating-endoscopic-reprocessing-and-surveillance-cultures
#2
Mohamed H Yassin, Rahman Hariri, Yasir Hamad, Juliet Ferrelli, Leeanna McKibben, Yohei Doi
BACKGROUND Endoscope-associated infections are reported despite following proper reprocessing methods. Microbiological testing can confirm the adequacy of endoscope reprocessing. Multiple controversies related to the method and interpretation of microbiological testing cultures have arisen that make their routine performance a complex target. OBJECTIVE We conducted a pilot study using disposable bronchoscopes (DBs) to simulate different reprocessing times and soaking times and to compare high-level disinfection versus ethylene oxide sterilization...
November 21, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27830191/comparative-genome-analysis-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-sequence-type-131-strains-from-nepal-and-japan
#3
Tohru Miyoshi-Akiyama, Jatan Bahadur Sherchan, Yohei Doi, Maki Nagamatsu, Jeevan B Sherchand, Sarmila Tandukar, Norio Ohmagari, Teruo Kirikae, Hiroshi Ohara, Kayoko Hayakawa
The global spread of extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli (ESBL-E. coli) has largely been driven by the pandemic sequence type 131 (ST131). This study aimed to determine the molecular epidemiology of their spread in two Asian countries with contrasting prevalence. We conducted whole-genome sequencing (WGS) of ESBL-E. coli ST131 strains collected prospectively from Nepal and Japan, two countries in Asia with a high and low prevalence of ESBL-E. coli, respectively. We also systematically compared these genomes with those reported from other regions using publicly available WGS data for E...
September 2016: MSphere
https://www.readbyqxmd.com/read/27828759/prevalence-of-extended-spectrum-%C3%AE-lactamases-ctx-m-8-and-ctx-m-2-producing-salmonella-serotypes-from-clinical-and-nonhuman-isolates-in-brazil
#4
Sueli Aparecida Fernandes, Carlos Henrique Camargo, Gabriela Rodrigues Francisco, Maria Fernanda Campagnari Bueno, Doroti Oliveira Garcia, Yohei Doi, Monique Ribeiro Tiba Casas
We characterized extended-spectrum β-lactamases (ESBL) enzymes among Salmonella strains isolated in Brazil from 2009 to 2014. Salmonella recovered from both clinical and nonhuman (food, poultry, and environment) sources were subjected to antimicrobial susceptibility testing. β-lactamases genes were detected by polymerase chain reaction/sequencing; plasmid profiles and transferability were assessed by S1-pulsed field gel electrophoresis (PFGE). Genetic diversity was evaluated by XbaI-PFGE. Out of 630 Salmonella strains screened, 46 displayed ESBL phenotype, distributed across 11 different serotypes...
November 9, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27821458/co-production-of-mcr-1-and-ndm-1-by-colistin-resistant-escherichia-coli-isolated-from-a-healthy-individual
#5
Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong Shen, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian
mcr-1, the first transferable plasmid-mediated colistin resistance gene, was reported in Escherichia coli isolates from food animals, food and patients in China and now has been reported worldwide (1).….
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27810466/proposed-primary-endpoints-for-use-in-clinical-trials-that-compare-treatment-options-for-bloodstream-infection-in-adults-a-consensus-definition
#6
REVIEW
Patrick N A Harris, John F McNamara, David C Lye, Joshua S Davis, Louis Bernard, Allen C Cheng, Yohei Doi, Vance G Fowler, Keith S Kaye, Leonard Leibovici, Jeffrey Lipman, Martin J Llewelyn, Silvia Munoz-Price, Mical Paul, Anton Y Peleg, Jesús Rodríguez-Baño, Benjamin A Rogers, Harald Seifert, Visanu Thamlikitkul, Guy Thwaites, Steven Y C Tong, John Turnidge, Riccardo Utili, Steven A R Webb, David L Paterson
OBJECTIVES: To define standardised endpoints to aid the design of trials that compare antibiotic therapies for bloodstream infection (BSI). METHODS: Prospective studies, randomised trials or registered protocols comparing antibiotic therapies for BSI, published from 2005 to 2016, were reviewed. Consensus endpoints for BSI studies were defined using a modified Delphi process. RESULTS: Different primary and secondary endpoints were defined for pilot (small-scale studies designed to evaluate protocol design, feasibility and implementation) and definitive trials (larger-scale studies designed to test hypotheses and influence clinical practice), as well as for Staphylococcus aureus and Gram-negative BSI...
October 31, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27747047/early-or-delayed-initiation-of-renal-replacement-therapy-for-critically-ill-patients-do-we-know-the-right-time
#7
COMMENT
Yohei Komaru, Kent Doi
No abstract text is available yet for this article.
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27712635/a-predictive-model-of-mortality-in-patients-with-bloodstream-infections-due-to-carbapenemase-producing-enterobacteriaceae
#8
Belén Gutiérrez-Gutiérrez, Elena Salamanca, Marina de Cueto, Po-Ren Hsueh, Pierluigi Viale, José Ramón Paño-Pardo, Mario Venditti, Mario Tumbarello, George Daikos, Vicente Pintado, Yohei Doi, Felipe Francisco Tuon, Ilias Karaiskos, Isabel Machuca, Mitchell J Schwaber, Özlem Kurt Azap, Maria Souli, Emmanuel Roilides, Spyros Pournaras, Murat Akova, Federico Pérez, Joaquín Bermejo, Antonio Oliver, Manel Almela, Warren Lowman, Benito Almirante, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Alvaro Pascual, Jesús Rodríguez-Baño
OBJECTIVE: To develop a score to predict mortality in patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE). PATIENTS AND METHODS: A multinational retrospective cohort study (INCREMENT project) was performed from January 1, 2004, through December 31, 2013. Patients with clinically relevant monomicrobial BSIs due to CPE were included and randomly assigned to either a derivation cohort (DC) or a validation cohort (VC)...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27683817/cd36-provides-host-protection-against-klebsiella-pneumoniae-intrapulmonary-infection-by-enhancing-lps-responsiveness-and-macrophage-phagocytosis
#9
Tolani F Olonisakin, Huihua Li, Zeyu Xiong, Elizabeth J K Kochman, Minting Yu, Yanyan Qu, Mei Hulver, Jay K Kolls, Claudette St Croix, Yohei Doi, Minh-Hong Nguyen, Robert M Q Shanks, Rama K Mallampalli, Valerian E Kagan, Anuradha Ray, Roy L Silverstein, Prabir Ray, Janet S Lee
Klebsiella pneumoniae remains an important cause of intrapulmonary infection and invasive disease worldwide. Klebsiella pneumoniae can evade serum killing and phagocytosis primarily through the expression of a polysaccharide capsule, but its pathogenicity is also influenced by host factors. We examined whether CD36, a scavenger receptor that recognizes pathogen and modified-self ligands, is a host determinant of Klebsiella pneumoniae pathogenicity. Despite differences in serum sensitivity and virulence of three distinct Klebsiella pneumoniae (hypermucoviscous K1, research K2, carbapenemase-producing ST258) strains utilized, the absence of CD36 significantly increased host susceptibility to acute intrapulmonary infection by K...
September 28, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27681484/the-pharmacokinetics-of-beraprost-sodium-following-single-oral-administration-to-subjects-with-impaired-kidney-function
#10
Masahiro Shimamura, Jun Miyakawa, Masaaki Doi, Kiyonobu Okada, Hajimu Kurumatani, Yoshitaka Mori, Keiyu Oshida, Ikumi Nakajo, Keishi Oikawa, Fumihiko Ushigome, Aiji Miyashita, Masanao Isono, Yohei Miyamoto
The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were measured following the single oral administration of 120 μg of BPS as the sustained-release tablet, TRK-100STP, under fasting conditions to 18 subjects with impaired kidney function (stage 2, 3, and 4 chronic kidney disease (CKD) (as categorized by the estimated glomerular filtration rate)) and to 6 age-, body weight-, and gender-matched subjects with normal kidney function (stage 1 CKD)...
September 28, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27629901/comparison-of-minocycline-susceptibility-testing-methods-for-carbapenem-resistant-acinetobacter-baumannii
#11
Peng Wang, Sarah L Bowler, Serena F Kantz, Roberta T Mettus, Yan Guo, Christi L McElheny, Yohei Doi
Treatment options for infections due to carbapenem-resistant Acinetobacter baumannii are extremely limited. Minocycline is a semisynthetic tetracycline derivative with activity against this pathogen. This study compared susceptibility testing methods that are used in clinical microbiology laboratories (Etest, disk diffusion, and Sensititre broth microdilution methods) for testing of minocycline, tigecycline, and doxycycline against 107 carbapenem-resistant A. baumannii clinical isolates. Susceptibility rates determined with the standard broth microdilution method using cation-adjusted Mueller-Hinton (MH) broth were 77...
December 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27626100/an-unlikely-pair-the-antimicrobial-synergy-of-polymyxin-b-in-combination-with-the-cystic-fibrosis-transmembrane-conductance-regulator-drugs-kalydeco-and-orkambi
#12
Elena K Schneider, Mohammad A K Azad, Mei-Ling Han, Qi Tony Zhou, Jiping Wang, Johnny X Huang, Matthew A Cooper, Yohei Doi, Mark A Baker, Phillip J Bergen, Mark T Muller, Jian Li, Tony Velkov
Novel combination therapies are desperately needed for combating lung infections caused by bacterial "superbugs". This study aimed to investigate the synergistic antibacterial activity of polymyxin B in combination with the cystic fibrosis (CF) drugs KALYDECO (ivacaftor) and ORKAMBI (ivacaftor + lumacaftor) against Gram-negative pathogens that commonly colonize the CF lung, in particular, the problematic Pseudomonas aeruginosa. The in vitro synergistic activity of polymyxin B combined with ivacaftor or lumacaftor was assessed using checkerboard and static time-kill assays against a panel of polymyxin-susceptible and polymyxin-resistant P...
July 8, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27624958/clinical-outcomes-drug-toxicity-and-emergence-of-ceftazidime-avibactam-resistance-among-patients-treated-for-carbapenem-resistant-enterobacteriaceae-infections
#13
Ryan K Shields, Brian A Potoski, Ghady Haidar, Binghua Hao, Yohei Doi, Liang Chen, Ellen G Press, Barry N Kreiswirth, Cornelius J Clancy, M Hong Nguyen
Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30-days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90-days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.
September 13, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27593176/the-global-epidemiology-of-carbapenemase-producing-enterobacteriaceae
#14
David van Duin, Yohei Doi
Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. Both clonal spread and plasmid-mediated transmission contribute to the ongoing rise in incidence of these bacteria. Among the 4 classes of β-lactamases defined by the Ambler classification system, the carbapenemases that confer carbapenem resistance in Enterobacteriaceae belong to 3 of them: Class A (K. pneumoniae carbapenemases, KPC), Class B (metallo-β-lactamases, MBL including New Delhi metallo-β-lactamases, NDM) and Class D (OXA-48-like carbapenemases)...
August 11, 2016: Virulence
https://www.readbyqxmd.com/read/27572405/characterization-of-a-novel-inchi2-plasmid-carrying-tandem-copies-of-blactx-m-2-in-a-fosa6-harboring-escherichia-coli-st410-strain
#15
Qinglan Guo, Baixing Ding, Thomas Jové, Nicole Stoesser, Vaughn S Cooper, Minggui Wang, Yohei Doi
Extended-spectrum β-lactamase gene blaCTX-M-2 is mainly associated with ISCR1 embedded in complex sul1-type integrons, but information on the genetic context of plasmids harboring the ISCR1-blaCTX-M-2module remains limited. In this study, a blaCTX-M-2-harboring plasmid pYD786-1 belonging to novel ST2-IncHI2 was sequenced and analyzed from an Escherichia coli ST410 clinical strain. pYD786-1 belonged to APEC-O1-R type IncHI2 plasmids which are widely distributed in human, poultry and livestock strains. It contained a multidrug resistance mosaic region (MRR) consisting of Tn21::In2 transposon backbone augmented by acquisition of duplicated ISCR1-blaCTX-M-2 Tn2411, a Tn21::In2 precursor, likely played a role in the generation of the MRR in pN13-01290_23, the putative progenitor plasmid of pYD786-1 found in a foodborne Salmonella strain...
August 29, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27297487/association-between-the-presence-of-aminoglycoside-modifying-enzymes-and-in-vitro-activity-of-gentamicin-tobramycin-amikacin-and-plazomicin-against-klebsiella-pneumoniae-carbapenemase-and-extended-spectrum-%C3%AE-lactamase-producing-enterobacter-species
#16
Ghady Haidar, Ammar Alkroud, Shaoji Cheng, Travis M Churilla, Bryce M Churilla, Ryan K Shields, Yohei Doi, Cornelius J Clancy, M Hong Nguyen
We compared the in vitro activities of gentamicin (GEN), tobramycin (TOB), amikacin (AMK), and plazomicin (PLZ) against 13 Enterobacter isolates possessing both Klebsiella pneumoniae carbapenemase and extended-spectrum β-lactamase (KPC+/ESBL+) with activity against 8 KPC+/ESBL-, 6 KPC-/ESBL+, and 38 KPC-/ESBL- isolates. The rates of resistance to GEN and TOB were higher for KPC+/ESBL+ (100% for both) than for KPC+/ESBL- (25% and 38%, respectively), KPC-/ESBL+ (50% and 17%, respectively), and KPC-/ESBL- (0% and 3%, respectively) isolates...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27270280/in-vitro-activity-of-fusidic-acid-containing-combinations-against-carbapenem-resistant-acinetobacter-baumannii-clinical-strains
#17
LETTER
Sarah L Bowler, Caressa N Spychala, Christi L McElheny, Roberta T Mettus, Yohei Doi
No abstract text is available yet for this article.
August 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27261267/glutathione-s-transferase-fosa6-of-klebsiella-pneumoniae-origin-conferring-fosfomycin-resistance-in-esbl-producing-escherichia-coli
#18
Qinglan Guo, Adam D Tomich, Christi L McElheny, Vaughn S Cooper, Nicole Stoesser, Minggui Wang, Nicolas Sluis-Cremer, Yohei Doi
OBJECTIVES: The objectives of this study were to elucidate the genetic context of a novel plasmid-mediated fosA variant, fosA6, conferring fosfomycin resistance and to characterize the kinetic properties of FosA6. METHODS: The genome of fosfomycin-resistant Escherichia coli strain YD786 was sequenced. Homologues of FosA6 were identified through BLAST searches. FosA6 and FosA(ST258) were purified and characterized using a steady-state kinetic approach. Inhibition of FosA activity was examined with sodium phosphonoformate...
September 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27250568/effects-of-smoking-and-its-cessation-on-creatinine-and-cystatin-c-based-estimated-glomerular-filtration-rates-and-albuminuria-in-male-patients-with-type-2-diabetes-mellitus-the-fukuoka-diabetes-registry
#19
Toshiaki Ohkuma, Udai Nakamura, Masanori Iwase, Hitoshi Ide, Hiroki Fujii, Tamaki Jodai, Shinako Kaizu, Yohei Kikuchi, Yasuhiro Idewaki, Akiko Sumi, Yoichiro Hirakawa, Takanari Kitazono
Cigarette smoking is an important modifiable risk factor for lifestyle diseases. The smoking rate remains high, and the prevalence of diabetes mellitus is increasing in Asian countries; however, few studies have examined the effects of smoking on chronic kidney disease (CKD) in Asian diabetic patients. The aim of the present study was to investigate the association between smoking and its cessation with CKD and its components in patients with type 2 diabetes. A total of 2770 Japanese male patients with type 2 diabetes aged ⩾20 years were divided according to the amount of cigarette smoking and the years since cessation...
June 2, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27208771/aminoglycoside-resistance-the-emergence-of-acquired-16s-ribosomal-rna-methyltransferases
#20
REVIEW
Yohei Doi, Jun-Ichi Wachino, Yoshichika Arakawa
Aminoglycoside-producing Actinobacteria are known to protect themselves from their own aminoglycoside metabolites by producing 16S ribosomal RNA methyltransferase (16S-RMTase), which prevents them from binding to the 16S rRNA targets. Ten acquired 16S-RMTases have been reported from gram-negative pathogens. Most of them posttranscriptionally methylate residue G1405 of 16S rRNA resulting in high-level resistance to gentamicin, tobramycin, amikacin, and plazomicin. Strains that produce 16S-RMTase are frequently multidrug-resistant or even extensively drug-resistant...
June 2016: Infectious Disease Clinics of North America
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