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https://www.readbyqxmd.com/read/28743946/identification-of-the-eskape-pathogens-by-mass-spectrometric-analysis-of-microbial-membrane-glycolipids
#1
Lisa M Leung, William E Fondrie, Yohei Doi, J Kristie Johnson, Dudley K Strickland, Robert K Ernst, David R Goodlett
Rapid diagnostics that enable identification of infectious agents improve patient outcomes, antimicrobial stewardship, and length of hospital stay. Current methods for pathogen detection in the clinical laboratory include biological culture, nucleic acid amplification, ribosomal protein characterization, and genome sequencing. Pathogen identification from single colonies by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of high abundance proteins is gaining popularity in clinical laboratories...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739789/contribution-of-tetb-efflux-pump-on-minocycline-susceptibility-among-carbapenem-resistant-acinetobacter-baumannii
#2
Peng Wang, Christi L McElheny, Roberta T Mettus, Robert M Q Shanks, Yohei Doi
Minocycline, a semi-synthetic tetracycline developed in the 1970s, has become an important treatment option against MDR A. baumannii infections, particularly those caused by carbapenem-resistant strains (1).….
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28739785/emergence-of-mcr-1-in-raoultella-ornithinolytica-and-escherichia-coli-from-retail-vegetables-china
#3
Juan Luo, Xu Yao, Luchao Lv, Yohei Doi, Xiuyu Huang, Sicheng Huang, Jian-Hua Liu
The presence of mcr-1 among Enterobacteriaceae isolates collected from retail vegetables in China between 2015 and 2016 were investigated. Two Raoultella ornithinolytica and seven Escherichia coli strains recovered from lettuce and tomato samples were identified as MCR-1-producers. Similar to isolates from animals and humans, the mcr-1 gene was located on the IncHI2/ST3, IncI2 or IncX4 plasmids. The presence of MCR-1-producing organisms in ready-to-eat food samples represents a serious risk for human health...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28587061/enhanced-osseointegration-of-a-modified-titanium-implant-with-bound-phospho-threonine-a-preliminary-in-vivo-study
#4
Yohei Okazaki, Kazuya Doi, Yoshifumi Oki, Reiko Kobatake, Yasuhiko Abe, Kazuhiro Tsuga
Implant surface topography is a key factor in achieving osseointegration. l-Threonine can be chemically and stably bonded to titanium surfaces by phosphorylation. This study investigated the degree of in vivo osseointegration of an implant with a novel o-phospho-l-threonine (p-Thr)-binding surface. MC3T3-E1 cells were seeded on the p-Thr binding surface and machined surface disks, and initial cell attachment was evaluated. p-Thr-binding and machined surface implants were tested in vivo by implantation into the femurs of three male New Zealand white rabbits, and the osseointegration was assessed by measurement of removal torque (RT) and bone-implant contact (BIC) ratio...
May 25, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28567443/correction-for-miyoshi-akiyama-et-al-comparative-genome-analysis-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-sequence-type-131-strains-from-nepal-and-japan
#5
Tohru Miyoshi-Akiyama, Jatan Bahadur Sherchan, Yohei Doi, Maki Nagamatsu, Jeevan B Sherchand, Sarmila Tandukar, Norio Ohmagari, Teruo Kirikae, Hiroshi Ohara, Kayoko Hayakawa
[This corrects the article DOI: 10.1128/mSphere.00289-16.].
May 2017: MSphere
https://www.readbyqxmd.com/read/28559250/ceftazidime-avibactam-is-superior-to-other-treatment-regimens-against-carbapenem-resistant-klebsiella-pneumoniae-bacteremia
#6
Ryan K Shields, M Hong Nguyen, Liang Chen, Ellen G Press, Brian A Potoski, Rachel V Marini, Yohei Doi, Barry N Kreiswirth, Cornelius J Clancy
There are no data comparing outcomes of patients treated with ceftazidime-avibactam vs. comparators for carbapenem-resistant Enterobacteriaceae infections. At our center, ceftazidime-avibactam treatment of carbapenem-resistant Klebsiella pneumoniae bacteremia was associated with higher rates of clinical success (P=0.006) and survival (P=0.01) than other regimens. Across treatment groups, there were no differences in underlying diseases, severity of illness, source of bacteremia, or strain characteristics (97% were KPC-producing)...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28555943/pro-angiogenic-tie-2-expressing-monocytes-tems-as-a-biomarker-of-the-effect-of-sorafenib-in-patients-with-advanced-hepatocellular-carcinoma
#7
Hirotaka Shoji, Sachiyo Yoshio, Yohei Mano, Hiroyoshi Doi, Masaya Sugiyama, Yosuke Osawa, Kiminori Kimura, Taeang Arai, Norio Itokawa, Masanori Atsukawa, Yoshihiko Aoki, Moto Fukai, Akinobu Taketomi, Masashi Mizokami, Tatsuya Kanto
Sorafenib, a multi-kinase inhibitor, inhibits tumor angiogenesis and is the first-line systemic therapy for patients with advanced hepatocellular carcinoma (HCC). However, due to its limited effects and frequent occurrence of side effects, biomarkers are needed to predict the effects of sorafenib. We considered the possibility of using TIE-2-expressing monocytes (TEMs) to predict the response in sorafenib-treated patients with advanced HCC. TEMs serve as a diagnostic marker of HCC and are related to angiogenesis...
May 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28523191/maternal-morbidity-in-women-with-placenta-previa-managed-with-prediction-of-morbidly-adherent-placenta-by-ultrasonography
#8
Midori Fujisaki, Seishi Furukawa, Yohei Maki, Masanao Oohashi, Koutarou Doi, Hiroshi Sameshima
Objective. To determine maternal morbidity in women with placenta previa managed with prediction of morbidly adherent placenta (MAP) by ultrasonography. Methods. A retrospective cohort study was undertaken comprising forty-one women who had placenta previa with or without risk factors for MAP. Women who had all three findings (bladder line interruption, placental lacunae, and absence of the retroplacental clear zone) were regarded as high suspicion for MAP and underwent cesarean section followed by hysterectomy...
2017: Journal of Pregnancy
https://www.readbyqxmd.com/read/28521000/the-ecology-of-extended-spectrum-%C3%AE-lactamases-esbls-in-the-developed-world
#9
Yohei Doi, Alina Iovleva, Robert A Bonomo
Background: Since the initial appearance in the 1980s, Enterobacteriaceae producing extended-spectrum β-lactamase (ESBL) have increased in prevalence and emerged as a major antimicrobial-resistant pathogen. The source of these antimicrobial-resistant bacteria in the developed world is an area of active investigation. Methods: A standard internet search was conducted with a focus on the epidemiology and potential sources of ESBL-producing Enterobacteriaceae in the developed world...
April 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28457352/carbapenem-resistant-enterobacteriaceae
#10
REVIEW
Alina Iovleva, Yohei Doi
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a major threat. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. Among CRE, those producing carbapenem-hydrolyzing β-lactamase enzymes (carbapenemase-producing Enterobacteriaceae) are particularly of concern because they tend to spread, and treatment is difficult. The carbapenemase groups most commonly encountered include KPC, NDM, and OXA-48. Treatment options are limited and include combinations of polymyxins, tigecycline, aminoglycosides, or carbapenems; newer agents with activity against CRE and better safety profiles are becoming available and will likely emerge as the preferred therapy...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28442293/effect-of-appropriate-combination-therapy-on-mortality-of-patients-with-bloodstream-infections-due-to-carbapenemase-producing-enterobacteriaceae-increment-a-retrospective-cohort-study
#11
Belén Gutiérrez-Gutiérrez, Elena Salamanca, Marina de Cueto, Po-Ren Hsueh, Pierluigi Viale, José Ramón Paño-Pardo, Mario Venditti, Mario Tumbarello, George Daikos, Rafael Cantón, Yohei Doi, Felipe Francisco Tuon, Ilias Karaiskos, Elena Pérez-Nadales, Mitchell J Schwaber, Özlem Kurt Azap, Maria Souli, Emmanuel Roilides, Spyros Pournaras, Murat Akova, Federico Pérez, Joaquín Bermejo, Antonio Oliver, Manel Almela, Warren Lowman, Benito Almirante, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Alvaro Pascual, Jesús Rodríguez-Baño
BACKGROUND: The best available treatment against carbapenemase-producing Enterobacteriaceae (CPE) is unknown. The objective of this study was to investigate the effect of appropriate therapy and of appropriate combination therapy on mortality of patients with bloodstream infections (BSIs) due to CPE. METHODS: In this retrospective cohort study, we included patients with clinically significant monomicrobial BSIs due to CPE from the INCREMENT cohort, recruited from 26 tertiary hospitals in ten countries...
July 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28438937/incx2-and-incx1-x2-hybrid-plasmids-coexisting-in-a-fosa6-producing-escherichia-coli-strain
#12
Qinglan Guo, Jiachun Su, Christi Lee McElheny, Nicole Stoesser, Yohei Doi, Minggui Wang
IncX plasmids are receiving much attention as vehicles of carbapenem and colistin resistance genes, such as blaNDM, blaKPC, and mcr-1 Among them, IncX2 subgroup plasmids remain rare. Here, we characterized IncX2 and IncX1-X2 hybrid plasmids coexisting in a FosA6-producing Escherichia coli strain that were possibly generated as a consequence of recombination events between an R6K-like IncX2 plasmid and a pLN126_33-like IncX1 plasmid. Variable multidrug resistance mosaic regions were observed in these plasmids, indicating their potential to serve as flexible carriers of resistance genes...
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28418308/chromosomal-16s-ribosomal-rna-methyltransferase-rmte1-in-escherichia-coli-sequence-type-448
#13
Bin Li, Marissa P Pacey, Yohei Doi
We identified rmtE1, an uncommon 16S ribosomal methyltransferase gene, in an aminoglycoside- and cephalosporin-resistant Escherichia coli sequence type 448 clinical strain co-harboring blaCMY-2. Long-read sequencing revealed insertion of a 101,257-bp fragment carrying both resistance genes to the chromosome. Our findings underscore E. coli sequence type 448 as a potential high-risk multidrug-resistant clone.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28407091/brassinosteroid-involvement-in-arabidopsis-thaliana-stomatal-opening
#14
Shin-Ichiro Inoue, Nozomi Iwashita, Yohei Takahashi, Eiji Gotoh, Eiji Okuma, Maki Hayashi, Ryohei Tabata, Atsushi Takemiya, Yoshiyuki Murata, Michio Doi, Toshinori Kinoshita, Ken-Ichiro Shimazaki
Stomata within the plant epidermis regulate CO2 uptake for photosynthesis and water loss through transpiration. Stomatal opening in Arabidopsis thaliana is determined by various factors, including blue light as a signal and multiple phytohormones. Plasma membrane transporters, including H+-ATPase, K+ channels and anion channels in guard cells, mediate these processes, and the activities and expression levels of these components determine stomatal aperture. However, the regulatory mechanisms involved in these processes are not fully understood...
June 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28376077/maternal-nutrient-restriction-in-guinea-pigs-leads-to-fetal-growth-restriction-with-evidence-for-chronic-hypoxia
#15
Alexander A Elias, Yohei Maki, Brad Matushewski, Karen Nygard, Timothy R H Regnault, Bryan S Richardson
BackgroundWe determined whether maternal nutrient restriction (MNR) in guinea pigs leading to fetal growth restriction (FGR) impacts markers for tissue hypoxia, implicating a mechanistic role for chronic hypoxia.MethodsGuinea pigs were fed ad libitum (Control) or 70% of the control diet before pregnancy, switching to 90% at mid-pregnancy (MNR). Near term, hypoxyprobe-1 (HP-1), a marker of tissue hypoxia, was injected into pregnant sows. Fetuses were then necropsied and liver, kidney, and placental tissues were processed for erythropoietin (EPO), EPO-receptor (EPOR), and vascular endothelial growth factor (VEGF) protein levels, and for HP-1 immunoreactivity (IR)...
July 2017: Pediatric Research
https://www.readbyqxmd.com/read/28373195/structural-modification-of-lipopolysaccharide-conferred-by-mcr-1-in-gram-negative-eskape-pathogens
#16
Yi-Yun Liu, Courtney E Chandler, Lisa M Leung, Christi L McElheny, Roberta T Mettus, Robert M Q Shanks, Jian-Hua Liu, David R Goodlett, Robert K Ernst, Yohei Doi
mcr-1 was initially reported as the first plasmid-mediated colistin resistance gene in clinical isolates of Escherichia coli and Klebsiella pneumoniae in China and has subsequently been identified worldwide in various species of the family Enterobacteriaceaemcr-1 encodes a phosphoethanolamine transferase, and its expression has been shown to generate phosphoethanolamine-modified bis-phosphorylated hexa-acylated lipid A in E. coli Here, we investigated the effects of mcr-1 on colistin susceptibility and on lipopolysaccharide structures in laboratory and clinical strains of the Gram-negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, K...
June 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28350901/gram-negative-bacterial-infections-research-priorities-accomplishments-and-future-directions-of-the-antibacterial-resistance-leadership-group
#17
Yohei Doi, Robert A Bonomo, David C Hooper, Keith S Kaye, James R Johnson, Cornelius J Clancy, Joshua T Thaden, Martin E Stryjewski, David van Duin
Antimicrobial resistance in pathogenic gram-negative bacteria is one of the most pressing challenges in the field of infectious diseases and is one of 4 key areas of unmet medical need identified by the Antibacterial Resistance Leadership Group (ARLG). The mission of the Gram-Negative Committee is to advance our knowledge of these challenging infections and implement studies to improve patient outcomes. Studies have fallen primarily into 2 broad categories: prospective cohort studies and interventional trials...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28282039/membrane-vesicle-mediated-bacterial-communication
#18
Masanori Toyofuku, Kana Morinaga, Yohei Hashimoto, Jenny Uhl, Hiroko Shimamura, Hideki Inaba, Philippe Schmitt-Kopplin, Leo Eberl, Nobuhiko Nomura
The classical quorum-sensing (QS) model is based on the assumption that diffusible signaling molecules accumulate in the culture medium until they reach a critical concentration upon which expression of target genes is triggered. Here we demonstrate that the hydrophobic signal N-hexadecanoyl-L-homoserine lactone, which is produced by Paracoccus sp., is released from cells by the aid of membrane vesicles (MVs). Packed into MVs, the signal is not only solubilized in an aqueous environment but is also delivered with varying propensities to different bacteria...
June 2017: ISME Journal
https://www.readbyqxmd.com/read/28139431/prevalence-risk-factors-outcomes-and-molecular-epidemiology-of-mcr-1-positive-enterobacteriaceae-in-patients-and-healthy-adults-from-china-an-epidemiological-and-clinical-study
#19
Yang Wang, Guo-Bao Tian, Rong Zhang, Yingbo Shen, Jonathan M Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R Walsh, Jianzhong Shen
BACKGROUND: The mcr-1 gene confers transferable colistin resistance. mcr-1-positive Enterobacteriaceae (MCRPE) have attracted substantial medical, media, and political attention; however, so far studies have not addressed their clinical impact. Herein, we report the prevalence of MCRPE in human infections and carriage, clinical associations of mcr-1-positive Escherichia coli (MCRPEC) infection, and risk factors for MCRPEC carriage. METHODS: We undertook this study at two hospitals in Zhejiang and Guangdong, China...
April 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28106103/sox2-and-rb1-in-esophageal-small-cell-carcinoma-their-possible-involvement-in-pathogenesis
#20
Hirotaka Ishida, Atsuko Kasajima, Takashi Kamei, Tsuyoshi Miura, Naomi Oka, Samaneh Yazdani, Yohei Ozawa, Fumiyoshi Fujishima, Akira Sakurada, Yasuhiro Nakamura, Yoichi Tanaka, Masafumi Kurosumi, Yuichi Ishikawa, Yoshinori Okada, Noriaki Ohuchi, Hironobu Sasano
Clinicopathological features and pathogenesis of esophageal small-cell carcinoma remain unclear. We hypothesized common cellular origin and pathogenesis in small-cell carcinoma of esophagus and lung associated with SOX2 overexpression and loss of Rb1. Expression of squamous-basal markers (CK5/6 and p40), glandular markers (CK18 and CEA), SOX2, and Rb1 were evaluated in 15 esophageal small-cell carcinomas, 46 poorly differentiated squamous cell carcinomas, and 88 small-cell lung carcinoma, as well as 16 embryonic esophagus...
May 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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