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Onabotulinumtoxina

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https://www.readbyqxmd.com/read/29762872/the-effect-of-onabotulinumtoxina-on-aura-frequency-and-severity-in-patients-with-hemiplegic-migraine-case-series-of-11-patients
#1
Tiffany Y Chen, Ivan Garza, David W Dodick, Carrie E Robertson
BACKGROUND: OnabotulinumtoxinA has been demonstrated to be effective for the preventive treatment of headache in individuals with chronic migraine and has been approved and recommended for this patient population. While the therapeutic effect of onabotulinumtoxinA on migraine headache is well documented, there is limited information on the effect of onabotulinumtoxinA on migraine aura. OBJECTIVE: Given the prolonged and often debilitating nature of aura in patients with hemiplegic migraine, our group sought to examine the effect of onabotulinumtoxinA on aura frequency and severity in this specific subset of migraine patients...
May 15, 2018: Headache
https://www.readbyqxmd.com/read/29762642/onabotulinumtoxina-and-hyaluronic-acid-in-facial-wrinkles-and-folds-a-prospective-open-label-comparison
#2
Joel L Cohen, Arthur Swift, Nowell Solish, Steve Fagien, Dee Anna Glaser
Background: OnabotulinumtoxinA and hyaluronic acid are effective in improving moderate-to-severe facial wrinkles and folds, with treatment selection traditionally based upon facial area. Objective: This prospective, multicenter, open-label, crossover study evaluated physician-rated efficacy and patient-rated outcomes following moderate-to-severe facial wrinkles and folds treatment with onabotulinumtoxinA and hyaluronic acid. Methods: 152 subjects (25-65 years) were randomized (1:1) to a treatment-sequence of onabotulinumtoxinA/hyaluronic acid or hyaluronic acid/onabotulinumtoxinA, with initial treatment administered on Day 1 and 6 additional visits: Week 2 (touch-up); Week 4 (crossover); Week 6 (touch-up); and Weeks 8, 12, and 24 (follow-up)...
May 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29762446/prospective-analysis-of-the-greater-occipital-nerve-location-in-patients-undergoing-occipital-nerve-decompression
#3
Jacqueline S Israel, Steve J Kempton, Ahmed M Afifi
BACKGROUND: Migraine surgery and onabotulinumtoxinA injections aim to deactivate neurovascular trigger points implicated in chronic headaches. The greater occipital nerve (GON) is a common trigger point. The depth of this nerve has not been previously described. The purpose of this study was to report the intraoperative location, including depth, of the GON in human subjects undergoing migraine surgery. METHODS: We reviewed records of patients who underwent GON decompression by a single surgeon...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29753213/onabotulinumtoxina-detrusor-injection-improves-female-sexual-function-in-women-with-overactive-bladder-wet-syndrome
#4
Matteo Balzarro, Emanuele Rubilotta, Andrea Braga, Silvia Bassi, Tania Processali, Walter Artibani, Maurizio Serati
OBJECTIVES: The correlation between changes in sexual function and improvements in LUTD in patients treated with OnabotulinumtoxinA (onaBoNT-A) detrusor injection is unclear and limited only to women with neurogenic OAB. The aim of this study was to evaluate the impact of OnabotulinumtoxinA (onaBoNT-A) injection on sexual function in women undergoing this treatment for idiopathic wet overactive bladder (OAB). STUDY DESIGN: This is a pilot three-center observational study including women affected by idiopathic wet overactive bladder refractory to standard conservative treatments and underwent onaBoNT-A injection...
May 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29753118/efficacy-and-safety-of-single-dose-onabotulinumtoxina-in-the-treatment-of-symptoms-of-osteoarthritis-of-the-knee-results-of-a-placebo-controlled-double-blind-study
#5
Timothy E McAlindon, Ulla Schmidt, Denise Bugarin, Steve Abrams, Till Geib, Ronald E DeGryse, Kimmie Kim, Thomas J Schnitzer
OBJECTIVE: To evaluate intraarticular onabotulinumtoxinA 400 U and 200 U in reducing symptoms of knee osteoarthritis (OA) in patients with nociceptive pain. DESIGN: A multicenter, double-blind, randomized, placebo-controlled study was conducted in adults with knee OA and a painDETECT questionnaire score of ≤12 (indicating nociceptive pain). Patients were randomized to receive intraarticular onabotulinumtoxinA 400 U or 200 U or placebo (saline) in the study knee on a 1:1:2 ratio and were followed-up for 24 weeks posttreatment...
May 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29747213/treatment-of-non-neurogenic-overactive-bladder-with-onabotulinumtoxina-systematic-review-and-meta-analysis-of-prospective-randomized-placebo-controlled-clinical-trials
#6
Raquel Martins Arruda, Claudia Cristina Takano, Manoel João Batista Castelo Girão, Jorge Milhem Haddad, Gabriel Francisco Aleixo, Rodrigo Aquino Castro
We performed a systematic review and meta-analysis of randomized placebo-controlled trials that studied non-neurogenic overactive bladder patients who were treated with 100 units of onabotulinumtoxinA or placebo. The primary purpose of our study was to evaluate the clinical effectiveness with regard to urinary urgency, urinary frequency, nocturia, and incontinence episodes. Our secondary purpose consisted of evaluating the adverse effects. Our initial search yielded 532 entries. Of these, seven studies met all the inclusion criteria (prospective, randomized, placebo-controlled studies, ≥ 3 points on the Jadad scale) and were selected for analysis...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29746857/women-undergoing-third-line-overactive-bladder-treatment-demonstrate-elevated-thermal-temporal-summation
#7
W Stuart Reynolds, Casey Kowalik, Joshua Cohn, Melissa Kaufman, Alan Wein, Roger Dmochowski, Stephen Bruehl
PURPOSE: To determine if women with overactive bladder (OAB) requiring 3rd line therapy demonstrate greater central sensitization, indexed by temporal summation to heat pain stimuli, than those with OAB. MATERIALS AND METHODS: We recruited 39 adult women with OAB from the Urology clinic who were planning to undergo interventional therapy for medication refractory OAB with either onabotulinumtoxinA bladder injection or sacral neuromodulation and 55 women with OAB, either newly seen in our Urology clinic or responding to advertisements for study participation...
May 7, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29680006/treatment-of-refractory-category-iii-nonbacterial-chronic-prostatitis-chronic-pelvic-pain-syndrome-with-intraprostatic-injection-of-onabotulinumtoxina-a-prospective-controlled-study
#8
Taha A Abdel-Meguid, Hisham A Mosli, Hasan Farsi, Ahmad Alsayyad, Abdulmalik Tayib, Moataz Sait, Ahmad Abdelsalam
INTRODUCTION: To evaluate the efficacy and safety of intraprostatic injections of onabotulinumtoxinA (onaBoNT-A) to treat refractory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). MATERIALS AND METHODS: Prospective two-group controlled study. Treatment group included adult men with refractory category-III nonbacterial CP/CPPS who underwent transurethral intraprostatic injections of onaBoNT-A (200 U). Control group included comparable patients who underwent cystoscopy only...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29679281/correction-to-onabotulinumtoxina-a-review-in-the-prevention-of-chronic-migraine
#9
James E Frampton, Stephen Silberstein
The article OnabotulinumtoxinA: A Review in the Prevention of Chronic Migraine, written by James E. Frampton and Stephen Silberstein, was originally published Online First without open access. After publication in volume 78, issue 5, pages 589-600 [funder] requested that the article be Open Choice to make the article an open access publication. Post-publication open access was funded by [funder]. Further details may be found at [MedEngine webpage link].
April 20, 2018: Drugs
https://www.readbyqxmd.com/read/29653162/inconsistency-in-the-definition-of-urinary-tract-infection-after-intravesical-botulinum-toxin-a-injection-a-systematic-review
#10
Andrew W Stamm, Sarah A Adelstein, Andrew Chen, Alvaro Lucioni, Kathleen C Kobashi, Una J Lee
PURPOSE: In order to more accurately examine the rate of urinary tract infection following onabotulinumtoxinA injection of the bladder, we systematically reviewed the literature for definitions of urinary tract infection utilized in series that reported on onabotulinumtoxinA injections and assessed them for consistency with guideline statements defining urinary tract infections. MATERIALS AND METHODS: A systematic review of the literature was performed via query using MEDLINE and EMBASE...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29643467/potential-orphan-drug-therapy-of-intravesical-liposomal-onabotulinumtoxin-a-for-ketamine-induced-cystitis-by-mucosal-protection-and-anti-inflammation-in-a-rat-model
#11
Wei-Chia Lee, Chia-Hao Su, You-Lin Tain, Cheng-Nan Tsai, Chun-Chieh Yu, Yao-Chi Chuang
Ketamine abusers may develop ulcerative cystitis and severe lower urinary tract symptoms, which is a medical dilemma. Recently, researchers have found the endemic of ketamine-induced cystitis worldwide. The intravesical administration of liposome-encapsulated onabotulinumtoxinA (Lipotoxin) might facilitate the healing of the damaged urothelium from liposomes, and reduce the urinary symptoms by onabotulinumtoxinA-induced chemo-denervation. Using female Sprague-Dawley rats, we investigated the effects of Lipotoxin on ketamine-induced cystitis...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29617060/a-prospective-real-world-analysis-of-onabotulinumtoxina-in-chronic-migraine-post-nice-u-k-technology-appraisal
#12
Anna P Andreou, Michele Trimboli, Adnan Al-Kaisy, Madeleine Murphy, Stefano Palmisani, Cherylin Fenech, Thomas Smith, Giorgio Lambru
OBJECTIVES: The National Institute for Health and Care Excellence (NICE) in the United Kingdom (UK) recommend the use of OnabotulinumtoxinA (BoNTA, Botox® ) in the management of chronic migraine (CM) following specific guidelines within the National Health Service (NHS). In view of the lack of data on the efficacy of this therapy following implementation of this guidelines in clinical practice and on the evaluation of guidance' compliance, we evaluate the effectiveness and safety of BoNTA in CM patients following the NICE guidelines...
April 4, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29596847/an-academic-debate-onabotulinumtoxina-for-chronic-migraine-preempt-derived-vs-customized-dosing-injection-paradigm
#13
Mark W Green, John F Rothrock
In 2010 onabotulinumtoxinA (OnabotA) was approved by the United States Food and Drug Administration for the treatment of chronic migraine (CM). Data supporting approval were derived primarily from two parallel placebo-controlled trials, the PREEMPT studies. Many clinicians and research investigators critical of those data have recommended that the dosing/injection paradigm for treating CM be "customized" to the needs of the individual patient rather than administered in a uniform fashion conforming to the methodology utilized in the PREEMPT studies...
March 26, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29571276/estimating-the-clinical-effectiveness-and-value-based-price-range-of-erenumab-for-the-prevention-of-migraine-in-patients-with-prior-treatment-failures-a-us-societal-perspective
#14
Richard B Lipton, Alan Brennan, Stephen Palmer, Anthony J Hatswell, Joshua K Porter, Sandhya Sapra, Guillermo Villa, Neel Shah, Stewart Tepper, David Dodick
BACKGROUND: Frequent migraine with four or more headache days per month is a common, disabling neurovascular disease. From a US societal perspective, this analysis models the clinical efficacy and estimates the value-based price (VBP) for erenumab, a fully human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor. METHODS: A Markov health state transition model was developed to estimate the incremental costs, quality-adjusted life-years (QALYs), and value-based price range for erenumab in migraine prevention...
April 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29551556/what-is-the-best-treatment-option-for-coexisting-pelvic-floor-dysfunctions
#15
Manuela Tutolo, Enrico Ammirati, Frank Van der Aa
Although both intravesical onabotulinumtoxinA injections and sacral neuromodulation could be offered in cases of bladder pain syndrome and overactive bladder syndrome, there is still no scientific agreement on the best option after failure of standard therapies.
December 2017: European Urology Focus
https://www.readbyqxmd.com/read/29532439/onabotulinumtoxina-a-review-in-the-prevention-of-chronic-migraine
#16
James E Frampton, Stephen Silberstein
An intramuscular formulation of onabotulinumtoxinA (onabotA; Botox® ) is currently the only therapy specifically approved for the prevention of headaches in adults with chronic migraine (CM) in the EU and North America. This article provides a narrative review of relevant data on the drug in this indication from an EU perspective. OnabotA was originally approved on the basis of pooled data from two phase III studies (PREEMPT 1 and 2). In these pivotal studies, injection of up to five cycles of onabotA (155-195 U/cycle) at 12-week intervals was generally well tolerated and effective in producing statistically significant and clinically meaningful improvements in headache symptoms, acute headache pain medication usage, headache impact and health-related quality of life in adults with CM, of whom approximately two-thirds were acute medication overusers and approximately one-third had failed to respond to ≥ 3 prior oral prophylactic therapies...
April 2018: Drugs
https://www.readbyqxmd.com/read/29528206/functional-gastrointestinal-disorders-functional-lower-gastrointestinal-disorders-in-adults
#17
Michael Malone, Abdul Waheed, Samiullah Samiullah
Functional lower gastrointestinal disorders include irritable bowel syndrome (IBS), functional constipation, functional fecal incontinence, and functional anorectal pain. These disorders are common and have significant medical and social effects. They also can be challenging to manage. Patients with mild symptoms may benefit from lifestyle modification. IBS is classified into two subtypes: diarrhea-predominant and constipation-predominant. Depending on the IBS subtype and its likely etiology, patients may benefit from treatment with antispasmodics, antidepressants, guanylate cyclase-C agonists, chloride channel activators, antidiarrheal agents, probiotics, and/or antibiotics...
March 2018: FP Essentials
https://www.readbyqxmd.com/read/29498553/onabotulinumtoxina-treatment-of-moderate-to-severe-glabellar-lines-in-chinese-subjects-after-laser-therapy-a-prospective-open-label-noncomparative-study
#18
Yan Wu, Zhong Lu, Yong Xie, Wei Zhang, Xiangdong Chen, Yuling Shi, Qin Li, Michael Halstead, John D Rogers, Michael Silberberg
INTRODUCTION: This study evaluated safety and efficacy of onabotulinumtoxinA for moderate to severe glabellar lines (GL) following laser therapy in Chinese subjects. MATERIALS AND METHODS: Subjects (n = 173) were followed for 120 days following a single onabotulinumtoxinA (20 U) treatment for GL after recent laser therapy. Subjects completed validated patient-reported outcomes, including Facial Lines Outcome 11-item (FLO-11) Questionnaire and Facial Lines Satisfaction Questionnaire (FLSQ)...
March 2, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29488655/clinical-outcomes-of-non-surgical-management-of-detrusor-leak-point-pressures-above-40-cm-water-in-adults-with-congenital-neurogenic-bladder
#19
Giulia I Lane, Ronak A Gor, Jenna Katorski, Sean P Elliott
AIMS: Neurogenic bladders (NGB) with detrusor leak point pressures >40 cm H2 O (dLPP > 40) have been associated with deterioration of renal function in children with myelomeningocele. For these children, careful pressure management preserves renal function. However, similar evidence is lacking in adult congenital urology (ACU) patients with NGB. We describe renal functional outcomes of non-surgical management of adults with dLPP > 40 or premicturition detrusor pressure (PMDP) >40 cm H2 O, consisting of close follow-up with urodynamic studies (UDS) and renal ultrasound (RUS), paired with adjustments to clean intermittent catheterization (CIC) frequency, anticholinergics, and addition of onabotulinumtoxinA toxin (BTX) injection...
February 28, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29485034/the-use-of-urodynamic-studies-for-the-followup-of-neurogenic-bladders-treated-with-onabotulinumtoxina
#20
Michelle Bergeron, Genevieve Nadeau, Katherine Moore
INTRODUCTION: Intradetrusor injections of onabotulinumtoxinA (BoNTA) is well-established as treatment for patients with neurogenic bladders. Urodynamics (UDS) are used at regular intervals during followup to monitor intravesical pressure. With regards to the discomfort and risks associated with UDS, our objective was to assess if UDS done at regular intervals in the followup of neurogenic bladders treated with BoNTA had an impact on management. METHODS: We retrospectively analyzed the medical records of adult patients with neurologic disorders treated with BoNTA for either detrusor overactivity or low bladder compliance at the Institut de Réadaptation en Déficience Physique de Québec (IRDPQ)...
February 23, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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