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https://www.readbyqxmd.com/read/29917289/fh-inactivation-in-hereditary-leiomyomatosis-and-renal-cell-cancer-is-synthetic-lethal-with-ferroptosis-induction
#1
Michael John Kerins, John Milligan, James Akira Wohlschlegel, Aikseng Ooi
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary cancer syndrome characterized by inactivation of the Krebs cycle enzyme fumarate hydratase (FH). HLRCC patients are at a high risk of developing kidney cancer of type 2 papillary morphology that is refractory to current radio-, immuno-, and chemo- therapies. Hence, an effective therapy for this deadly form of cancer is urgently needed. Here we show that FH inactivation (FH-/- ) proves synthetic lethal with inducers of ferroptosis, an iron-dependent and nonapoptotic form of cell death...
June 19, 2018: Cancer Science
https://www.readbyqxmd.com/read/29917273/catheterization-for-treating-neurogenic-lower-urinary-tract-dysfunction-in-patients-with-multiple-sclerosis-a-systematic-review-a-report-from-the-neuro-urology-promotion-committee-of-the-international-continence-society-ics
#2
REVIEW
Jure Tornic, Andrea M Sartori, Jerzy B Gajewski, Ashley Cox, Marc P Schneider, Nadim A Youssef, Livio Mordasini, Emmanuel Chartier-Kastler, Lucas M Bachmann, Thomas M Kessler
AIM: To systematically assess all available evidence on efficacy and safety of catheterization for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). METHODS: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of Embase, Medline, Scopus, Cochrane register (last search March 3, 2018) and by screening of reference lists and reviews...
June 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29917258/curcumin-ameliorates-cisplatin-induced-cystopathy-via-activating-nrf2-pathway
#3
Yun Peng Shao, Qiao Zhou, Yun Peng Li, Si Cong Zhang, He Wei Xu, Shuo Wu, Bai Xin Shen, Liu Cheng Ding, Jun Xue, Zheng Sen Chen, Zhong Qing Wei
OBJECTIVES: The present work evaluated preventive effect of curcumin on cisplatin-induced bladder cystopathy. METHODS: Fifteen female rats were divided into (i) Control group administered with physiological saline solution for 5 days; (ii) Cis-P group injected with cisplatin (6 mg/kg); and (iii) Cis-Cur group given cisplatin (6 mg/kg) with curcumin for 5 consecutive days. The function of bladder was measured by means of urodynamic analysis. Furthermore, hematoxylin-eosin staining and Masson trichrome staining were performed for morphological analysis...
June 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29917254/erectile-function-and-gonadal-hormones-levels-in-men-with-end-stage-renal-disease-it-s-relevance-to-duration-of-haemodialysis
#4
Abul-Fotouh Ahmed, Mahmoud Shaban, Abdullah Daoud, Nagah Mohamed, Ahmed Solyman, Ahmed Fahim
In this study, we evaluated the relationship between haemodialysis (HD) duration and erectile function status and gonadal hormones serum levels in adult men with end-stage renal disease (ESRD). A total of 118 men with ESRD on chronic HD were eligible for analysis. The erectile dysfunction (ED) was defined and graded according to the international index of erectile function (IIEF-5) score. The serum levels of follicle stimulating hormones (FSH), luteinising hormone (LH), testosterone (TST), prolactin (PRL) and estradiol (E2) were measured using the standard laboratory technique...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29917237/the-extracellular-matrix-glycoprotein-tenascin-x-regulates-peripheral-sensory-and-motor-neurones
#5
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo J A Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
The extracellular matrix (ECM) is not only an integral structural molecule, but is also critical for a wide range of cellular functions. The glycoprotein tenascin-X (TNX) predominates in the ECM of tissues like skin and regulates tissue structure through anti-adhesive interactions with collagen. Monogenic TNX deficiency causes painful joint hypermobility and skin hyperelasticity, symptoms characteristic of hypermobility-Ehlers Danlos Syndrome (hEDS). hEDS patients also report consistently increased visceral pain and gastrointestinal (GI) dysfunction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917212/hyperphosphorylation-of-protein-tau-in-hippocampus-may-cause-cognitive-dysfunction-of-propofol-anesthetized-rats
#6
H-B Zheng, Y-T Fu, G Wang, L-H Sun, Y-Y Fan, T-W Yang
OBJECTIVE: We aimed to explore the effect of hyperphosphorylation of Tau on cognitive function of propofol-anesthetized rats. MATERIALS AND METHODS: Thirty 2-month-old male Wistar rats weighing 180-220 g were randomly divided into 3 groups (n=10): group of treating with saline (C group), group of treating with propofol for 1 hour (P1) and 24 h (P24 group). The cognitive function of rats was tested by Morris water maze before and 1 h or 24 h after drug administration...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917120/the-role-of-immune-cells-in-brain-development-and-neurodevelopmental-diseases
#7
Shogo Tanabe, Toshihide Yamashita
During brain development, the generation of neurons and glial cells is rigorously regulated by diverse mechanisms including the immune system. Dysfunction of the developing system results in the onset of neurodevelopmental disorders and psychological disorders. Recent studies have demonstrated that the immune system is implicated in brain development. As the central nervous system is physically separated from the circulatory system by the blood-brain barrier, circulating immune cells are unable to infiltrate into the brain parenchyma...
June 15, 2018: International Immunology
https://www.readbyqxmd.com/read/29917053/echocardiographic-strain-analysis-for-the-early-detection-of-left-ventricular-systolic-diastolic-dysfunction-and-dyssynchrony-in-a-mouse-model-of-physiological-aging
#8
Claudio de Lucia, Markus Wallner, Deborah M Eaton, Huaqing Zhao, Steven R Houser, Walter J Koch
Heart disease is the leading cause of hospitalization and death worldwide, severely affecting health care costs. Aging is a significant risk factor for heart disease and the senescent heart is characterized by structural and functional changes including diastolic and systolic dysfunction as well as left ventricular (LV) dyssynchrony. Speckle-tracking based strain echocardiography (STE) has been shown as a non-invasive, reproducible and highly sensitive methodology to evaluate LV function in both animal models and humans...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29917037/high-plasma-apolipoprotein-b-identifies-obese-subjects-who-best-ameliorate-white-adipose-tissue-dysfunction-and-glucose-induced-hyperinsulinemia-after-a-hypocaloric-diet
#9
Simon Bissonnette, Nathalie Saint-Pierre, Valerie Lamantia, Catherine Leroux, Viviane Provost, Yannick Cyr, Remi Rabasa-Lhoret, May Faraj
Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29917004/is-female-sex-an-independent-risk-factor-for-early-mortality-in-isolated-coronary-artery-bypass-graft-a-propensity-matched-analysis
#10
Andrea Garatti, Alessandro Parolari, Alberto Canziani, Eugenio Mossuto, Andrea Daprati, Ali Abu Farah, Daniele Brugnetti, Marco Ranucci, Lorenzo Menicanti
AIMS: Despite several studies reporting a higher mortality rate for women undergoing isolated coronary artery bypass graft (CABG) surgery, this issue has not been completely clarified. The aim of the current study was to determine if sex differences in CABG surgery affect adjusted operative results and operative mortality. METHODS: Between January 2005 and December 2012, 3756 consecutive patients (3009 men and 747 women) underwent isolated CABG at our institution...
June 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29917003/sacubitril-valsartan-from-a-large-clinical-trial-to-clinical-practice
#11
Edoardo Sciatti, Michele Senni, Carlo M Lombardi, Mauro Gori, Marco Metra
: The Prospective Comparison of Angiotensin Receptor Antagonist and Neprilysin Inhibitor with Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial has shown a reduction in the risk of death and heart failure hospitalizations with sacubitril/valsartan, compared with enalapril, in patients with heart failure and reduced ejection fraction. Guidelines now recommend the substitution of angiotensin-converting enzyme inhibitors or AT1 blockers with sacubitril/valsartan in patients with heart failure and reduced ejection fraction...
June 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29916966/rates-of-neuropsychological-dysfunction-in-fibromyalgia-and-rheumatoid-arthritis-an-automated-clinical-rating-approach
#12
Luis D Medina, Linda Hirshberg, Michael J Taylor, Paul E Gilbert, Robert K Heaton
BACKGROUND/OBJECTIVE: Fibromyalgia (FM) is a chronic pain syndrome of unknown etiology that can include subjective cognitive symptoms and variable evidence of cognitive dysfunction. Rates of occurrence and severity of cognitive impairment remain unclear. Additionally, comparison of this group with other pain conditions has been limited. The current cross-sectional study sought to identify rates of clinically significant cognitive impairment in FM and rheumatoid arthritis (RA) using an automated clinical rating approach...
June 18, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29916882/paradigm-shift-in-the-management-of-irresectable-colorectal-liver-metastases-living-donor-auxiliary-partial-orthotopic-liver-transplantation-in-combination-with-two-stage-hepatectomy-ld-rapid
#13
Alfred Königsrainer, Silke Templin, Ivan Capobianco, Ingmar Königsrainer, Michael Bitzer, Lars Zender, Bence Sipos, Lothar Kanz, Silvia Wagner, Silvio Nadalin
OBJECTIVE: to report the first case of resection and partial liver segment 2-3 transplantation with delayed total hepatectomy (RAPID) from living donor in a patient affected of irresectable colorectal liver metastases (i-CRLM) BACKGROUND:: A renaissance of liver transplantation (LT) for i-CRLM has been recently observed. The Norwegian SECA trial demonstrated a 5-year overall survival rate of approximately 60%, notwithstanding early tumor recurrence. The RAPID technique was recently introduced as alternative to whole deceased donor LT, but it is limited by poor availability of splittable organs and many organisational aspects...
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916850/sphincter-of-oddi-dysfunction-sphincter-of-oddi-dysfunction-or-discordance-what-is-the-state-of-the-art-in-2018
#14
Jong Jin Hyun, Richard A Kozarek
PURPOSE OF REVIEW: To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS: The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing that neither endoscopic retrograde cholangiopancreatography-manometry nor endoscopic sphincterotomy are appropriate for SOD type III. Pain management in the latter patients has reverted to neuromodulating agents, and recent studies have suggested a role for duloxetine and potentially acupuncture...
June 16, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29916835/the-modern-cardiovascular-care-unit-the-cardiologist-managing-multiorgan-dysfunction
#15
Thomas Bochaton, Eric Bonnefoy-Cudraz, Nadia Aissaoui
PURPOSE OF REVIEW: Despite many advances in the management of critically ill patients, cardiogenic shock remains a challenge because it is associated with high mortality. Even if there is no universally accepted definition of cardiogenic shock, end-perfusion organ dysfunction is an obligatory and major criterion of its definition.Organ dysfunction is an indicator that cardiogenic shock is already at an advanced stage and is undergoing a rapid self-aggravating evolution. The aim of the review is to highlight the importance to diagnose and to manage the organ dysfunction occurring in the cardiogenic shock patients by providing the best literature published this year...
June 16, 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/29916565/-care-related-intervention-in-rehabilitative-pneumology-pulmonary-rehabilitation-in-chronic-obstructive-broncopneumopathies-copd-can-benefit-from-a-multidisciplinary-approach
#16
Michele Vitacca, Dina Visca, Antonio Spanevello
OBJECTIVES: Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation. Cardiovascular diseases, osteoporosis, depression/anxiety, musculoskeletal impairment and obstructive sleep apnea are frequent and important comorbidities in COPD, often under-diagnosed, and associated with poor health status and prognosis. METHODS: Pulmonary rehabilitation improves symptoms, quality of life, pulmonary function, and health care in patients with chronic respiratory disease...
February 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916559/features-of-atrial-fibrillation-in-wild-type-transthyretin-cardiac-amyloidosis-a-systematic-review-and-clinical-experience
#17
Yuliya Y Mints, Gheorghe Doros, John L Berk, Lawreen H Connors, Frederick L Ruberg
AIMS: Wild-type transthyretin (ATTRwt) cardiac amyloidosis has emerged as an important cause of heart failure in the elderly. Atrial fibrillation (AF) commonly affects older adults with heart failure and is associated with reduced survival, but its role in ATTRwt is unclear. We sought to explore the clinical impact of AF in ATTRwt. METHODS AND RESULTS: Patients with biopsy-proven ATTRwt cardiac amyloidosis (n = 146) were retrospectively identified, and clinical, echocardiographic, and biochemical data were collected...
June 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29916537/liraglutide-improves-cognitive-impairment-via-the-ampk-and-pi3k-akt-signaling-pathways-in-type-2-diabetic-rats
#18
Ying Yang, Hui Fang, Gang Xu, Yanfeng Zhen, Yazhong Zhang, Jinli Tian, Dandan Zhang, Guyue Zhang, Jing Xu
Liraglutide is a type of glucagon‑like‑peptide 1 receptor agonist, which has been reported as a novel type of antidiabetic agent with numerous benefits, including cardiovascular and neuroprotective effects. To the best of our knowledge, few studies to date have reported the potential mechanism underlying the neuroprotective effects of liraglutide on rats with type 2 diabetes mellitus (T2DM). The present study aimed to investigate the neuroprotective actions of liraglutide in diabetic rats and to determine the mechanisms underlying these effects...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916527/mitochondrial-dysfunction-induces-the-invasive-phenotype-and-cell-migration-and-invasion-through-the-induction-of-akt-and-ampk-pathways-in-lung-cancer-cells
#19
Si-Yoon Han, Yun-Jeong Jeong, Yongsoo Choi, Soon-Kyung Hwang, Young-Seuk Bae, Young-Chae Chang
Mitochondria are well known for their important roles in oxidative phosphorylation, amino acid metabolism, fatty acid oxidation and ion homeostasis. Although the effects of mitochondrial dysfunction on tumorigenesis in various cancer cells have been reported, the correlation between mitochondrial dysfunction and epithelial‑to‑mesenchymal transition (EMT) in lung cancer development and metastasis has not been well elucidated. In the present study, the effects of mitochondrial dysfunction on EMT and migration in lung cancer cells were investigated using inhibitors of mitochondrial respiration, oligomycin A and antimycin A...
June 18, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29916449/antinuclear-antibodies-in-scrub-typhus-transient-occurrence-during-acute-illness
#20
Maria Koshy, John Mathew, Reginald Alex, John Antony Jude, Ravikar Ralph, Thambu David Sudarsanam, Sowmya Sathyendra, J Visalakshi, John Victor Peter
Background & objectives: The pathological hallmark of scrub typhus infection is focal or disseminated vasculitis. As with other infections, antinuclear antibodies (ANA) have been previously described in scrub typhus. However, the underlying mechanisms and implications of this immunological phenomenon is not well understood. In the present work it was assessed whether ANA is associated with illness severity and outcomes. Methods: In this prospective study spanning one year, patients fulfilling the diagnostic criteria for scrub typhus were recruited...
January 2018: Journal of Vector Borne Diseases
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