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https://www.readbyqxmd.com/read/28728564/comparison-of-the-protein-coding-genomes-of-three-deep-sea-sulfur-oxidising-bacteria-candidatus-ruthia-magnifica-candidatus-vesicomyosocius-okutanii-and-thiomicrospira-crunogena
#1
Susan E McGill, Daniel Barker
OBJECTIVE: " Candidatus Ruthia magnifica", "Candidatus Vesicomyosocius okutanii" and Thiomicrospira crunogena are all sulfur-oxidising bacteria found in deep-sea vent environments. Recent research suggests that the two symbiotic organisms, "Candidatus R. magnifica" and "Candidatus V. okutanii", may share common ancestry with the autonomously living species T. crunogena. We used comparative genomics to examine the genome-wide protein-coding content of all three species to explore their similarities...
July 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28727919/comprehensive-multiphase-cmp-nmr-monitoring-of-the-structural-changes-and-molecular-flux-within-a-growing-seed
#2
Blythe Fortier-McGill, Rudraksha Dutta Majumdar, Leayen Lam, Ronald Soong, Yalda Liaghati Mobarhan, Andre Sutrisno, Ries de Visser, Myrna J Simpson, Heather Wheeler, Malcolm Campbell, Antonie Gorissen, Andre J Simpson
A relatively recent technique termed Comprehensive Multiphase (CMP) NMR spectroscopy was used to study the growth and associated metabolomic changes of 13C-labeled wheat seeds and germinated seedlings. CMP-NMR enables the study of all phases in intact samples: liquid, gel-like, semi-solid and solid, by combining all required electronics into a single NMR probe and can be used for investigating biological processes such as seed germination. All components, from the most liquid like (i.e. dissolved metabolites) to the most rigid or solid like (seed coat) were monitored in-situ over 4 days...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28713853/factors-associated-with-acute-postoperative-pain-following-breast-reconstruction
#3
Anita R Kulkarni, Andrea L Pusic, Jennifer B Hamill, Hyungjin M Kim, Ji Qi, Edwin G Wilkins, Randy S Roth
INTRODUCTION: Post-mastectomy breast reconstruction has become an increasingly important component of breast cancer treatment. Unfortunately, some patients experience severe postoperative pain, placing them at risk for increased clinical morbidity and the development of disabling chronic pain. In an attempt to identify at-risk patients, we prospectively evaluated patient characteristics and medical/surgical variables associated with more severe acute post-reconstruction pain. METHODS: Women (N = 2207; one-week 82...
March 2017: JPRAS Open
https://www.readbyqxmd.com/read/28711468/effect-of-initiating-use-of-an-insulin-pump-in-adults-with-type-1-diabetes-using-multiple-daily-insulin-injections-and-continuous-glucose-monitoring-diamond-a-multicentre-randomised-controlled-trial
#4
Roy W Beck, Tonya D Riddlesworth, Katrina J Ruedy, Craig Kollman, Andrew J Ahmann, Richard M Bergenstal, Anuj Bhargava, Bruce W Bode, Stacie Haller, Davida F Kruger, Janet B McGill, William Polonsky, David Price, Elena Toschi
BACKGROUND: The benefit of initiation of insulin pump therapy (continuous subcutaneous insulin infusion; CSII) in patients with type 1 diabetes using continuous glucose monitoring (CGM) has not been studied. We aimed to assess glycaemic outcomes when switching from multiple daily injections (MDI) to CSII in adults with type 1 diabetes using CGM. METHODS: In this multicentre, randomised controlled trial, 75 adults with type 1 diabetes in the CGM group of the DIAMOND trial were randomly assigned via the study website using a computer-generated sequence to continue MDI or switch to CSII, with continuation of CGM, for 28 weeks...
July 12, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28710048/long-term-results-of-deep-brain-stimulation-of-the-anterior-cingulate-cortex-for-neuropathic-pain
#5
Sandra Gj Boccard, Simon J Prangnell, Laurie Pycroft, Binith Cheeran, Liz Moir, Erlick Ac Pereira, James J Fitzgerald, Alexander L Green, Tipu Z Aziz
BACKGROUND: Deep Brain Stimulation of the Anterior Cingulate Cortex is a recent technique that has shown some promising short-term results in patients with chronic refractory neuropathic pain. Three years after the first case-series, we assessed its efficacy on a larger cohort, with longer follow-up. METHODS: 24 patients (19 males; 49.1 years) with neuropathic pain underwent bilateral ACC DBS. Patient reported outcome measures were collected pre- and post-surgery, using the Numerical Rating Scale (NRS), Short-Form 36 quality of life (SF-36), McGill pain (MPQ) and EuroQol-5D questionnaires...
July 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28709680/patient-satisfaction-with-laser-sintered-removable-partial-dentures-a-crossover-pilot-clinical-trial
#6
Balqees Almufleh, Elham Emami, Omar Alageel, Fabiana de Melo, Francois Seng, Eric Caron, Samer Abi Nader, Ashwaq Al-Hashedi, Rubens Albuquerque, Jocelyne Feine, Faleh Tamimi
STATEMENT OF PROBLEM: Clinical data regarding newly introduced laser-sintered removable partial dentures (RPDs) are needed before this technique can be recommended. Currently, only a few clinical reports have been published, with no clinical studies. PURPOSE: This clinical trial compared short-term satisfaction in patients wearing RPDs fabricated with conventional or computer-aided design and computer-aided manufacturing (CAD-CAM) laser-sintering technology. MATERIAL AND METHODS: Twelve participants with partial edentulism were enrolled in this pilot crossover double-blinded clinical trial...
July 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28701300/duodenal-and-ileal-glucose-infusions-differentially-alter-gastrointestinal-peptides-appetite-response-and-food-intake-a-tube-feeding-study
#7
Sally D Poppitt, Hyun Sang Shin, Anne-Thea McGill, Stephanie C Budgett, Kim Lo, Malcolm Pahl, Janice Duxfield, Mark Lane, John R Ingram
Background: Activation of the ileal brake through the delivery of nutrients into the distal small intestine to promote satiety and suppress food intake provides a new target for weight loss. Evidence is limited, with support from naso-ileal lipid infusion studies.Objective: The objective of the study was to investigate whether glucose infused into the duodenum and ileum differentially alters appetite response, food intake, and secretion of satiety-related gastrointestinal peptides.Design: Fourteen healthy male participants were randomly assigned to a blinded 4-treatment crossover, with each treatment of single-day duration...
July 12, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28700580/infant-viewing-of-social-scenes-is-under-genetic-control-and-is-atypical-in-autism
#8
John N Constantino, Stefanie Kennon-McGill, Claire Weichselbaum, Natasha Marrus, Alyzeh Haider, Anne L Glowinski, Scott Gillespie, Cheryl Klaiman, Ami Klin, Warren Jones
Long before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomonically impaired in children affected by autism. Here we show that variation in viewing of social scenes, including levels of preferential attention and the timing, direction and targeting of individual eye movements, is strongly influenced by genetic factors, with effects directly traceable to the active seeking of social information...
July 12, 2017: Nature
https://www.readbyqxmd.com/read/28699996/quality-of-life-and-religious-spiritual-coping-in-palliative-cancer-care-patients
#9
Ticiane Dionizio de Sousa Matos, Silmara Meneguin, Maria de Lourdes da Silva Ferreira, Helio Amante Miot
Objectives: to compare the quality of life and religious-spiritual coping of palliative cancer care patients with a group of healthy participants; assess whether the perceived quality of life is associated with the religious-spiritual coping strategies; identify the clinical and sociodemographic variables related to quality of life and religious-spiritual coping. Method: cross-sectional study involving 96 palliative outpatient care patient at a public hospital in the interior of the state of São Paulo and 96 healthy volunteers, using a sociodemographic questionnaire, the McGill Quality of Life Questionnaire and the Brief Religious-Spiritual Coping scale...
July 10, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28699301/prospective-evaluation-of-patient-usage-of-above-and-below-threshold-waveforms-with-traditional-spinal-cord-stimulation-devices
#10
Stephanie Owusu, Alexander Huynh, Eric Gruenthal, Julia Prusik, Stephane Owusu-Sarpong, Rasan Cherala, Sophia Peng, Julie G Pilitsis, Sarah E McCallum
OBJECTIVES: Spinal cord stimulation (SCS) is an efficacious therapy used to treat chronic pain. The type of SCS programming is important in improving patients' quality of life and overall satisfaction. In this study, 19 patients who underwent SCS with traditional devices were given between 4 and 6 programs including programs with stimulation below sensory threshold and above sensory threshold. Usage patterns and preferences were assessed. METHODS: SCS patients were given 4-6 programs, some above sensory threshold and some below threshold immediately postoperatively after permanent implantation...
July 11, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28694676/3d-augmented-reality-mirror-visual-feedback-therapy-applied-to-the-treatment-of-persistent-unilateral-upper-extremity-neuropathic-pain-a-preliminary-study
#11
Dominique Mouraux, Eric Brassinne, Stéphane Sobczak, Antoine Nonclercq, Nadine Warzée, Phillip S Sizer, Turgay Tuna, Benoît Penelle
Objective: We assessed whether or not pain relief could be achieved with a new system that combines 3D augmented reality system (3DARS) and the principles of mirror visual feedback. Methods: Twenty-two patients between 18 and 75 years of age who suffered of chronic neuropathic pain. Each patient performed five 3DARS sessions treatment of 20 mins spread over a period of one week. The following pain parameters were assessed: (1) visual analogic scale after each treatment session (2) McGill pain scale and DN4 questionnaire were completed before the first session and 24 h after the last session...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28694437/integrated-behavioural-and-stable-isotope-data-reveal-altered-diet-linked-to-low-breeding-success-in-urban-dwelling-blue-tits-cyanistes-caeruleus
#12
Christopher J Pollock, Pablo Capilla-Lasheras, Rona A R McGill, Barbara Helm, Davide M Dominoni
Animals often show reduced reproductive success in urban compared to adjacent natural areas. The lower availability and quality of natural food in cities is suggested as one key limiting factor. However, only few studies have provided conclusive support by simultaneously assessing food availability, diet and fitness. We consolidate this evidence by taking a holistic approach, comparing blue tits breeding in forest, suburban and urban areas. We (a) assessed arthropod availability, (b) investigated parental provisioning behaviour, (c) inferred diet through stable isotope analysis, and (d) measured reproductive success...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693922/shared-decision-making-and-outcomes-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#13
REVIEW
Michael Saheb Kashaf, Elizabeth Tyner McGill, Zackary Dov Berger
OBJECTIVE: Type 2 diabetes is a chronic disease which necessitates the development of a therapeutic alliance between patient and provider. This review systematically examines the association between treatment shared decision-making (SDM) and outcomes in diabetes. METHODS: A range of bibliographic databases and gray literature sources was searched. Included studies were subjected to dual data extraction and quality assessment. Outcomes were synthesized using meta-analyses where reporting was sufficiently homogenous or alternatively synthesized in narrative fashion...
June 27, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28693563/the-efficacy-of-traditional-acupuncture-on-patients-with-chronic-neck-pain-study-protocol-of-a-randomized-controlled-trial
#14
Yiling Yang, Xiaoxia Yan, Hongmei Deng, Dian Zeng, Jianpeng Huang, Wenbin Fu, Nenggui Xu, Jianhua Liu
BACKGROUND: A large number of randomized trials on the use of acupuncture to treat chronic pain have been conducted. However, there is considerable controversy regarding the effectiveness of acupuncture. We designed a randomized trial involving patients with chronic neck pain (CNP) to investigate whether acupuncture is more effective than a placebo in treating CNP. METHODS/DESIGN: A five-arm, parallel, single-blinded, randomized, sham-controlled trial was designed...
July 10, 2017: Trials
https://www.readbyqxmd.com/read/28693329/a-novel-approach-to-improving-patient-experience-in-orthopedics
#15
Spencer M Stein, Sarav S Shah, Alanna Carcich, Marlena McGill, Isaac Gammal, Michael Langino, Thomas Mauri
The patient experience domain comprises a significant portion of the Hospital Value-Based Purchasing program. This study investigated whether an intervention focusing on attending physician awareness, resident and physician assistant education, and multidisciplinary patient-centric care had an effect on patient perceived physician communication and overall hospital ratings. Responses to the Hospital Consumer Assessment of Healthcare Providers and Systems survey were reviewed in 2014 and 2015. Patients' perceptions that the physician explained their condition in ways they understood and the overall hospital rating improved significantly after implantation of the model ( P < ...
February 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28692702/impaired-insula-functional-connectivity-associated-with-persistent-pain-perception-in-patients-with-complex-regional-pain-syndrome
#16
Jae-Hun Kim, Soo-Hee Choi, Joon Hwan Jang, Do-Hyeong Lee, Kyung-Jun Lee, Won Joon Lee, Jee Youn Moon, Yong Chul Kim, Do-Hyung Kang
Given that the insula plays a contributory role in the perception of chronic pain, we examined the resting-state functional connectivity between the insular cortex and other brain regions to investigate neural underpinnings of persisting perception of background pain in patients with complex regional pain syndrome (CRPS). A total of 25 patients with CRPS and 25 matched healthy controls underwent functional magnetic resonance imaging at rest. With the anterior and posterior insular cortices as seed regions, we compared the strength of the resting-state functional connectivity between the two groups...
2017: PloS One
https://www.readbyqxmd.com/read/28691602/somatosensory-feedback-to-the-cheek-during-virtual-visual-feedback-therapy-enhances-pain-alleviation-for-phantom-arms
#17
Akimichi Ichinose, Yuko Sano, Michihiro Osumi, Masahiko Sumitani, Shin-Ichiro Kumagaya, Yasuo Kuniyoshi
BACKGROUND: Patients who suffer from phantom limb pain can perceive tactile stimuli applied to the cheek on their affected side as if it were coming from their phantom limb, a phenomenon called "referred sensation." OBJECTIVES: To investigate the analgesic effect produced by tactile feedback provided to the cheek during neurorehabilitation using visual feedback. METHODS: Nine participants with phantom upper limb pain performed virtual reality neurorehabilitation exercises in which they repeatedly touched a target object with a virtual representation of their affected limb...
July 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28688969/the-steinberg-centre-for-simulation-and-interactive-learning-at-mcgill-university
#18
Carmen L Mueller, Genevieve Cyr, Ilana Bank, Farhan Bhanji, Laura Birnbaum, Miriam Boillat, Marie-Eve Bolduc, Jeffrey Chankowsky, Evelyn Constantin, Beth-Ann Cummings, Rachel Fisher, Philippe Legault, N Hugo Marchand, Luis Monton, Teresa Rudkin, Bayane Sabsabi, Niki Soilis, Daniel Zigman, Rajesh Aggarwal
Simulation allows for learner-centered health professions training by providing a safe environment to practice and make mistakes without jeopardizing patient care. It was with this goal in mind that the McGill Medical Simulation Center was officially opened on September 14, 2006, as a partnership between McGill University, the Faculty of Medicine and its affiliated hospitals. Its mandate is to provide state-of-the-art facilities to support simulation-based medical and allied health education initiatives. Since its inception, the center, recently renamed the Steinberg Center for Simulation and Interactive Learning (SCSIL), has undergone a major expansion and logged more than 130,000 learner visits...
July 5, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28688566/dysphagia-in-healthy-children-characteristics-and-management-of-a-consecutive-cohort-at-a-tertiary-centre
#19
Orysya Svystun, Wendy Johannsen, Rabin Persad, Justine M Turner, Carina Majaesic, Hamdy El-Hakim
OBJECTIVE: Whereas the literature is replete with reports on complex children with dysphagia (DP), the parameters characterizing non-neurologically impaired (NNI) children have been underreported, leaving a substantial knowledge gap. We set to characterize a consecutive cohort of NNI children, their management, and outcomes. METHODS: We undertook a retrospective case series. Children (<18 years old) attending a tertiary multidisciplinary swallowing clinic were eligible...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28684100/automaticity-of-force-application-during-simulated-brain-tumor-resection-testing-the-fitts-and-posner-model
#20
Abdulgadir Bugdadi, Robin Sawaya, Duaa Olwi, Gmaan Al-Zhrani, Hamed Azarnoush, Abdulrahman Jafar Sabbagh, Ghusn Alsideiri, Khalid Bajunaid, Fahad E Alotaibi, Alexander Winkler-Schwartz, Rolando Del Maestro
OBJECTIVE: The Fitts and Posner model of motor learning hypothesized that with deliberate practice, learners progress through stages to an autonomous phase of motor ability. To test this model, we assessed the automaticity of neurosurgeons, senior residents, and junior residents when operating on 2 identical tumors using the NeuroVR virtual reality simulation platform. DESIGN: Participants resected 9 identical simulated tumors on 2 occasions (total = 18 resections)...
July 3, 2017: Journal of Surgical Education
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