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https://www.readbyqxmd.com/read/28210480/cross-cultural-psychometric-evaluation-of-the-dutch-mcgill-qol-questionnaire-for-breast-cancer-patients
#1
T De Vrieze, D Coeck, H Verbelen, N Devoogdt, W Tjalma, N Gebruers
AIM OF THE STUDY: Assessing the cross-cultural psychometric properties of the Dutch-MQoL for breast cancer patients. METHODS: 26 patients were recruited at the Antwerp University Hospital. Eligible patients filled in the MQoL on different moments in time in order to evaluate clinimetric properties. To determine the validity; MQoL was correlated to the EORTC QLQ-C30. Internal consistency was analysed using Cronbach's and test-retest reliability was determined by ICC...
December 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28209197/accuracy-and-generalizability-of-using-automated-methods-for-identifying-adverse-events-from-electronic-health-record-data-a-validation-study-protocol
#2
Christian M Rochefort, David L Buckeridge, Andréanne Tanguay, Alain Biron, Frédérick D'Aragon, Shengrui Wang, Benoit Gallix, Louis Valiquette, Li-Anne Audet, Todd C Lee, Dev Jayaraman, Bruno Petrucci, Patricia Lefebvre
BACKGROUND: Adverse events (AEs) in acute care hospitals are frequent and associated with significant morbidity, mortality, and costs. Measuring AEs is necessary for quality improvement and benchmarking purposes, but current detection methods lack in accuracy, efficiency, and generalizability. The growing availability of electronic health records (EHR) and the development of natural language processing techniques for encoding narrative data offer an opportunity to develop potentially better methods...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28205336/achieving-serum-urate-targets-in-gout-an-audit-in-a-gout-oriented-rheumatology-practice
#3
Elizabeth J M Corbett, Peta Pentony, Neil W McGill
AIM: To assess the proportion of patients with gout who achieve target serum urate levels, the drug regime required and the reasons for failing to do so. METHODS: We reviewed the files of all patients with gout who presented to a gout-oriented rheumatology practice between January 2010 and September 2014. RESULTS: Two hundred and thirty patients agreed to commence urate lowering therapy (ULT); 73% achieved their urate target, including 74% with non-tophaceous gout (target ≤ 0...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28190508/navigating-the-clinical-trial-pathway-conception-design-execution-and-results-dissemination
#4
John S Sampalis, Joanne Watson, Stella Boukas, Marianna Boukas, Natalie Harvey, Sanjay Machado, Michel Bordeleau, Emmanouil Rampakakis
Dr Sampalis is founder, Chief Executive Officer, and Chief Scientific Officer of JSS Medical Research Inc, founded in 1997. He is a tenured professor of Surgery and Epidemiology & Biostatistics of McGill University, the University of Montreal and University of Laval. Recognized as a leading clinical epidemiologist and one of the top trauma researchers in Canada, he possesses extensive expertise in health services research, clinical trials, and offers services as a Research and Epidemiological Consultant for numerous pharmaceutical companies, hospitals and government organizations and agencies...
March 2017: Surgery
https://www.readbyqxmd.com/read/28185557/reconstruction-of-ancestral-rna-sequences-under-multiple-structural-constraints
#5
Olivier Tremblay-Savard, Vladimir Reinharz, Jérôme Waldispühl
BACKGROUND: Secondary structures form the scaffold of multiple sequence alignment of non-coding RNA (ncRNA) families. An accurate reconstruction of ancestral ncRNAs must use this structural signal. However, the inference of ancestors of a single ncRNA family with a single consensus structure may bias the results towards sequences with high affinity to this structure, which are far from the true ancestors. METHODS: In this paper, we introduce achARNement, a maximum parsimony approach that, given two alignments of homologous ncRNA families with consensus secondary structures and a phylogenetic tree, simultaneously calculates ancestral RNA sequences for these two families...
November 11, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28183509/assessment-of-myocardial-microstructural-dynamics-by-in%C3%A2-vivo-diffusion-tensor-cardiac-magnetic-resonance
#6
Sonia Nielles-Vallespin, Zohya Khalique, Pedro F Ferreira, Ranil de Silva, Andrew D Scott, Philip Kilner, Laura-Ann McGill, Archontis Giannakidis, Peter D Gatehouse, Daniel Ennis, Eric Aliotta, Majid Al-Khalil, Peter Kellman, Dumitru Mazilu, Robert S Balaban, David N Firmin, Andrew E Arai, Dudley J Pennell
BACKGROUND: Cardiomyocytes are organized in microstructures termed sheetlets that reorientate during left ventricular thickening. Diffusion tensor cardiac magnetic resonance (DT-CMR) may enable noninvasive interrogation of in vivo cardiac microstructural dynamics. Dilated cardiomyopathy (DCM) is a condition of abnormal myocardium with unknown sheetlet function. OBJECTIVES: This study sought to validate in vivo DT-CMR measures of cardiac microstructure against histology, characterize microstructural dynamics during left ventricular wall thickening, and apply the technique in hypertrophic cardiomyopathy (HCM) and DCM...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28178394/enhancing-evidence-based-clinical-assessment-in-a-large-public-psychiatric-hospital-using-behavior-data-collected-by-direct-care-nursing-staff
#7
Amanda C McGill, Nicole Tuomi Jones, Angela Richard Boss, Brian Sheitman
This column shares the best evidence-based strategies and innovative ideas on how to facilitate the learning and implementation of EBP principles and processes by clinicians as well as nursing and interprofessional students. Guidelines for submission are available at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1741-6787.
February 8, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28178120/the-top-cited-systematic-reviews-meta-analyses-in-tuberculosis-research-a-prisma-compliant-systematic-literature-review-and-bibliometric-analysis
#8
Yonggang Zhang, Jin Huang, Liang Du
BACKGROUND: The top-cited systematic reviews/meta-analyses in tuberculosis research have not been identified. The objective of this study was to identify the 100 top-cited systematic reviews/meta-analyses in tuberculosis research, and to understand factors resulting in highly cited works, and establish trends in systematic reviews/meta-analyses in tuberculosis research. METHODS: The Web of Science Core Collection was searched for systematic reviews/meta-analyses on tuberculosis up to January 31, 2016...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28174332/spiritual-well-being-and-correlated-factors-in-subjects-with-advanced-copd-or-lung-cancer
#9
Takaaki Hasegawa, Momoko Kawai, Nanori Kuzuya, Yohei Futamura, Akane Horiba, Takashi Ishiguro, Tsutomu Yoshida, Toshiyuki Sawa, Yasuyuki Sugiyama
BACKGROUND: Spiritual care for patients with COPD has rarely been discussed, and thus much remains unknown about their needs. The aims of this study were to identify the factors associated with spiritual well-being and to compare the levels of spiritual well-being between subjects with advanced COPD and those with inoperable lung cancer. METHODS: A total of 96 subjects with COPD or lung cancer participated in this study, which was conducted between December 2014 and April 2016...
February 7, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28170090/parents-attitudes-toward-genetic-testing-of-children-for-health-conditions-a-systematic-review
#10
REVIEW
Qishan Lim, Brittany C McGill, Veronica F Quinn, Katherine M Tucker, David Mizrahi, Andrea Farkas Patenaude, Meera Warby, Richard J Cohn, Claire E Wakefield
This review assessed parents' attitudes toward childhood genetic testing for health conditions, with a focus on perceived advantages and disadvantages. We also evaluated the factors that influence parents' attitudes toward childhood genetic testing. We searched Medline, Medline In-Process, EMBASE, PsycINFO, Social Work Abstracts and CINAHL. We screened 945 abstracts and identified 21 studies representing the views of 3934 parents. Parents reported largely positive attitudes toward childhood genetic testing across different genetic tests with varying medical utility...
February 7, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28169489/psychological-and-endocrine-factors-and-pain-after-mastectomy
#11
D Nishimura, S Kosugi, Y Onishi, N Ihara, K Wakaizumi, H Nagata, T Yamada, T Suzuki, S Hashiguchi, H Morisaki
BACKGROUND: This prospective study was designed to examine the associations of demographic, clinical, psychological and neuroendocrine factors with acute and chronic post-operative pain following partial mastectomy. METHODS: Sixty-four female patients scheduled for partial mastectomy were enrolled. Pre-operative anxiety/depression was assessed, using the Hospital Anxiety and Depression Scale (HADS). Pre-operative 24-h urinary cortisol levels were measured 2 days before surgery...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28168942/validating-the-factor-structure-and-testing-measurement-invariance-of-modified-short-form-mcgill-pain-questionnaire-ortho-sf-mpq-for-orthodontic-pain-assessment
#12
Satpal S Sandhu
OBJECTIVE: To validate the factor structure of recently modified Short-Form McGill Pain Questionnaire (Ortho-SF-MPQ) to assess orthodontic pain; and to test its Measurement Invariance (MI) across gender. METHODS: 180 orthodontic patients were enrolled in this study. 0.016 inch Super-elastic NiTi arch wire was used in 0.022″ × 0.028″ slot pre-adjusted edgewise appliance. After initial arch wire placement, pain was assessed at T1 (24 hours), T2 (day 3), and T3 (day 7) by using the Ortho-SF-MPQ which consists of seven sensory (pressure, sore, aching, tight, throbbing, pulling, miserable) and four affective (uncomfortable, strange, frustrating, annoying) descriptors...
February 7, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28168335/at-home-pulse-oximetry-in-children-undergoing-adenotonsillectomy-for-obstructive-sleep-apnea
#13
Martino Pavone, Nicola Ullmann, Elisabetta Verrillo, Giancarlo De Vincentiis, Emanuela Sitzia, Renato Cutrera
: Nocturnal pulse oximetry has a high positive predictive value for polysomnographically diagnosed obstructive sleep apnoea (OSA) in children. When significant adenotonsillar hypertrophy is diagnosed, adenotonsillectomy (T&A) represents a common treatment for OSA in children. We investigated the role of pulse oximetry in predicting those patients, referred for suspected OSA, who subsequently needed T&A. At-home nocturnal pulse oximetry was performed on 380 children (65.7% males), median age 4...
February 6, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28156250/efficacy-of-deep-rtms-for-neuropathic-pain-in-the-lower-limb-a-randomized-double-blind-crossover-trial-of-an-h-coil-and-figure-8-coil
#14
Takeshi Shimizu, Koichi Hosomi, Tomoyuki Maruo, Yuko Goto, Masaru Yokoe, Yu Kageyama, Toshio Shimokawa, Toshiki Yoshimine, Youichi Saitoh
OBJECTIVE Electrical motor cortex stimulation can relieve neuropathic pain (NP), but its use requires patients to undergo an invasive procedure. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) using a figure-8 coil can relieve NP noninvasively, but its ability to relieve lower limb pain is still limited. Deep rTMS using an H-coil can effectively stimulate deep brain regions and has been widely used for the treatment of various neurological diseases; however, there have been no clinical studies comparing the effectiveness of figure-8 coils and H-coils...
February 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28152014/apigenin-selective-ck2-inhibitor-increases-ikaros-expression-and-improves-t-cell-homeostasis-and-function-in-murine-pancreatic-cancer
#15
Nadine Nelson, Karoly Szekeres, Cristina Iclozan, Ivannie Ortiz Rivera, Andrew McGill, Gbemisola Johnson, Onyekachi Nwogu, Tomar Ghansah
Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously shown that downregulation of Ikaros occurs as a result of its protein degradation by the ubiquitin-proteasome system in our Panc02 tumor-bearing (TB) mouse model. Mechanistically, we observed a deregulation in the balance between Casein Kinase II (CK2) and protein phosphatase 1 (PP1), which suggested that increased CK2 activity is responsible for regulating Ikaros' stability in our model...
2017: PloS One
https://www.readbyqxmd.com/read/28150188/customized-smartpeg-for-measurement-of-resonance-frequency-of-mini-dental-implants
#16
Jagjit Singh Dhaliwal, Rubens F Albuquerque, Ali Fakhry, Sukhbir Kaur, Jocelyne S Feine
BACKGROUND: One-piece narrow diameter implants (NDIs) have been recommended as "Single-tooth replacements in the anterior zones, single posterior, multiple-unit fixed dental prosthesis (FDP), edentulous jaws to be rehabilitated with FDP, and edentulous jaws rehabilitation with overdentures in situations with reduced mesiodistal space or reduced ridge width." (ITI consensus 2013). Since NDIs can be immediately loaded, it is important to be able to carry out stability testing. We developed and validated a customized SmartPeg for this type of implant to measure the Implant Stability Quotient (ISQ)...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28145038/predictability-in-community-dynamics
#17
Benjamin Blonder, Derek E Moulton, Jessica Blois, Brian J Enquist, Bente J Graae, Marc Macias-Fauria, Brian McGill, Sandra Nogué, Alejandro Ordonez, Brody Sandel, Jens-Christian Svenning
The coupling between community composition and climate change spans a gradient from no lags to strong lags. The no-lag hypothesis is the foundation of many ecophysiological models, correlative species distribution modelling and climate reconstruction approaches. Simple lag hypotheses have become prominent in disequilibrium ecology, proposing that communities track climate change following a fixed function or with a time delay. However, more complex dynamics are possible and may lead to memory effects and alternate unstable states...
February 1, 2017: Ecology Letters
https://www.readbyqxmd.com/read/28131571/short-communication-evaluation-of-the-prep10-energy-protein-and-amino-acid-allowable-milk-equations-in-comparison-with-the-national-research-council-model
#18
Robin R White, Tyler McGill, Rebecca Garnett, Robert J Patterson, Mark D Hanigan
The objective of this work was to evaluate the precision and accuracy of the milk yield predictions made by the PREP10 model in comparison to those from the National Research Council (NRC) Nutrient Requirements of Dairy Cattle. The PREP10 model is a ration-balancing system that allows protein use efficiency to vary with production level. The model also has advanced AA supply and requirement calculations that enable estimation of AA-allowable milk (MilkAA) based on 10 essential AA. A literature data set of 374 treatment means was collected and used to quantitatively evaluate the estimates of protein-allowable milk (MilkMP) and energy-allowable milk yields from the NRC and PREP10 models...
January 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28128522/clinicopathological-relevance-of-antithyroglobulin-antibodies-in-low-risk-papillary-thyroid-cancer
#19
Grégoire B Morand, Sabrina D da Silva, Alex M Mlynarek, Martin J Black, Richard J Payne, Michael P Hier
OBJECTIVE: The extent of initial surgical management in papillary thyroid cancer (PTC) is controversial. We examined whether the presence of perioperative antithyroglobulin antibodies (TGA) could predict long-term recurrence and occurrence of adverse features among a homogenous group of PTC patients. METHODS: The clinical features of PTC patients treated at a single institution (Jewish General Hospital, McGill University, Montreal, Canada) were obtained from the medical records and all clinicopathologic information were reviewed...
January 27, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28124735/disease-burden-and-pain-in-obese-cancer-patients-with-chemotherapy-induced-peripheral-neuropathy
#20
Emily Cox-Martin, Lisa H Trahan, Matthew G Cox, Patrick M Dougherty, Emily A Lai, Diane M Novy
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) and obesity are prevalent in cancer survivors and decrease quality of life; however, the impact of the co-occurrence of these conditions has garnered little attention. This study investigated differences between obese and non-obese cancer survivors with CIPN and predictors of symptom burden and pain. METHODS: Patients with CIPN were administered the MD Anderson Symptom Inventory and a modified version of pain descriptors from the McGill Pain Inventory...
January 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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