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Lucy Gee, Heather C Smith, Zohal Ghulam-Jelani, Hirah Khan, Julia Prusik, Paul J Feustel, Sarah E McCallum, Julie G Pilitsis
BACKGROUND: Chronic pain causes a significant burden to the US health care system, is difficult to treat, and remains a significant contributor to increased opioid use in the United States. Spinal cord stimulation (SCS) has been FDA approved for the treatment of chronic pain. OBJECTIVE: To evaluate the hypothesis that SCS reduces opioid use, and alone maintains clinical outcome measures of pain and psychosocial determinants of health. METHODS: In this prospective cohort study, we evaluated 86 patients undergoing SCS surgery for the treatment of chronic pain between September 2012 and August 2015...
March 12, 2018: Neurosurgery
Mark W Werneke, Susan Edmond, Michelle Young, David Grigsby, Brian McClenahan, Troy McGill
BACKGROUND AND PURPOSE: Physiotherapy has an important role in managing patients with non-specific low back pain who experience elevated psychosocial distress or risk for chronic disability. In terms of evidence-based physiotherapy practice, cognitive-behavioural approaches for patients at high psychosocial risk are the recommended management to improve patient treatment outcomes. Evidence also suggests that directional preference (DP) is an important treatment effect modifier for prescribing specific exercises for patients to improve outcomes...
March 14, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
Andrew J Lutkewitte, George G Schweitzer, Stefanie Kennon-McGill, Melissa M Clemens, Laura P James, Hartmut Jaeschke, Brian N Finck, Mitchell R McGill
No abstract text is available yet for this article.
March 10, 2018: Food and Chemical Toxicology
Mjs Parker, N W McGill
No abstract text is available yet for this article.
March 13, 2018: Scandinavian Journal of Rheumatology
Zachary L McCormick, Andrew Hendrix, David Dayanim, Bryan Clay, Amy Kirsling, Norman Harden
Objective: We present a technical protocol for rigorous assessment of patient-reported outcomes and psychophysical testing relevant to lumbar sympathetic blocks for the treatment of postamputation pain (PAP). This description is intended to inform future prospective investigation. Design: Series of four participants from a blinded randomized sham-controlled trial. Setting: Tertiary, urban, academic pain medicine center. Subjects: Four participants with a single lower limb amputation and associated chronic PAP...
March 8, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Rebecca Lyndsey Hardiman, Peter McGill
Fragile X Syndrome (FXS) appears to be associated with an increased risk for engaging in challenging behaviour, particularly self-injury, relative to those with mixed aetiology learning disabilities. Such behavioural issues are reported to be of high concern for those providing support. As such, this systematic review aimed to gain further epidemiological data regarding challenging behaviours in individuals with FXS, including: self-injurious behaviour (SIB), hand-biting as a specific topography of SIB, aggression and property destruction...
March 7, 2018: Research in Developmental Disabilities
Jennifer E McGill, Andrew S Hanzlicek, Kate S Kukanich, Gary D Norsworthy, Audrey K Cook
Objectives The objective of this study was to determine if urine Histoplasma antigen ( HAg) enzyme immunoassay (EIA) concentrations at the time of diagnosis and prior to the administration of antifungal agents are predictive of outcome for cats infected with Histoplasma capsulatum and to determine if compromised renal function affects urine HAg EIA measurements. Methods Medical records at four institutions were searched to identify cats diagnosed with histoplasmosis between April 2012 and December 2015. Pretreatment urine Histoplasma EIA values were recorded, along with patient signalment, serum creatinine concentration, urine specific gravity, site(s) of infection and survival data...
March 1, 2018: Journal of Feline Medicine and Surgery
Birgit Frauscher, Nicolas von Ellenrieder, Rina Zelmann, Irena Doležalová, Lorella Minotti, André Olivier, Jeffery Hall, Dominique Hoffmann, Dang Khoa Nguyen, Philippe Kahane, François Dubeau, Jean Gotman
In contrast to scalp EEG, our knowledge of the normal physiological intracranial EEG activity is scarce. This multicentre study provides an atlas of normal intracranial EEG of the human brain during wakefulness. Here we present the results of power spectra analysis during wakefulness. Intracranial electrodes are placed in or on the brain of epilepsy patients when candidates for surgical treatment and non-invasive approaches failed to sufficiently localize the epileptic focus. Electrode contacts are usually in cortical regions showing epileptic activity, but some are placed in normal regions, at distance from the epileptogenic zone or lesion...
March 1, 2018: Brain: a Journal of Neurology
Baijun Hu, Dawei Gao, Yihe He
OBJECTIVES: The aim of this study is to investigate the efficacy of fibula fixation in the early treatment of osteonecrosis of the femoral head (ONFH). METHODS: 130 patients with ONFH were selected and randomly divided into control group and observation group. Patients in the control group received core decompression treatment, while patients in the observation group received fibula fixation. The local microcirculation was observed by dynamic contrast-enhanced MRI, necrotic volume was measured using MRI, articular surface collapse by using X-ray, McGill pain questionnaire was used to understand and compared the joint pain condition...
March 1, 2018: Journal of Musculoskeletal & Neuronal Interactions
Pablo Zoroquiain, Christina Mastromonaco, Matthew Balaszi, Jade Lasiste, Sultan Aldrees, Nabil Saheb, Miguel Noel Burnier
PURPOSE: To compare the histopathological morphometry of the trabecular meshwork and ciliary processes in pseudophakic eyes and phakic eyes using advanced image analyzer technology. SETTING: McGill University, Montreal, Quebec, Canada. DESIGN: Retrospective case series. METHODS: Thirty-five pseudophakic eyes and 25 phakic eyes were sectioned and converted into digital slides. The total trabecular meshwork area and the ciliary body stroma were demarcated...
January 2018: Journal of Cataract and Refractive Surgery
Shashikumar Ramadugu, Satish C Nagabushnam, Nagendra Katuwal, Kaushik Chatterjee
Introduction: Mirror therapy suggested to help relieve phantom limb pain (PLP) by resolving the visual- proprioceptive dissociation in the brain, but studies so far either had shorter follow-up or smaller sample size. Materials and Methods: In this randomized single crossover trial, 64 amputees with PLP in the age group of 15-75 years of age were distributed into test and control groups by simple randomization method. Of these 28 in control and 32 in test groups, respectively, completed the 4 weeks of mirror therapy and 12 weeks of follow-up assessments...
October 2017: Indian Journal of Psychiatry
Boris Waldman, Jean-Claude Ansquer, David R Sullivan, Alicia J Jenkins, Neil McGill, Luke Buizen, Timothy M E Davis, James D Best, Liping Li, Michael D Feher, Christelle Foucher, Y Antero Kesaniemi, Jeffrey Flack, Michael C d'Emden, Russell S Scott, John Hedley, Val Gebski, Anthony C Keech
BACKGROUND: Gout is a painful disorder and is common in type 2 diabetes. Fenofibrate lowers uric acid and reduces gout attacks in small, short-term studies. Whether fenofibrate produces sustained reductions in uric acid and gout attacks is unknown. METHODS: In the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial, participants aged 50-75 years with type 2 diabetes were randomly assigned to receive either co-micronised fenofibrate 200 mg once per day or matching placebo for a median of 5 years follow-up...
February 26, 2018: Lancet Diabetes & Endocrinology
Man-Kyu Song, Soo-Hee Choi, Do-Hyeong Lee, Kyung-Jun Lee, Won Joon Lee, Do-Hyung Kang
Objective: Cognitive-behavioral therapy (CBT) is effective in patients with chronic pain. However, the efficacy of CBT for impaired empathy has not been studied in this population. We investigated the effect of CBT on empathy in patients with chronic pain. Methods: Patients with severe chronic pain were recruited. Empathy was assessed before and after CBT using the Interpersonal Reactivity Index (IRI). The patients underwent eight sessions over the course of 1 month conducted...
February 28, 2018: Psychiatry Investigation
Biljana Kurtović, Krešimir Rotim, Inga Mladić Batinica, Milan Milošević, Boris Božić, Sonja Kalauz
Lumbar discectomy is the most common surgical treatment for intervertebral disc extrusion. Postoperative pain is a common clinical problem that greatly affects the length of hospitalization, functional status and patient quality of life. Th e aim of this study was to compare the postoperative analgesic effi cacy of paracetamol administered intermittently and through patient-controlled analgesia (PCA) pump following single level lumbar discectomy. Patients who underwent elective lumbar discectomy of intervertebral disc extrusion at the L4-L5 level diagnosed by magnetic resonance of the lumbosacral spine were included in the study...
June 2017: Acta Clinica Croatica
Sarah K McGill
No abstract text is available yet for this article.
March 2018: Endoscopy
Majid Mahmoodzadeh, Maryam Farhadian, Sara Alijani, Fatemeh Azizi
OBJECTIVES: The aim of this study was to compare two initial arch wires, 0.014″ A-NiTi and 0.016″ Heat Activated NiTi (HANT), for amount of tooth alignment and perception of pain. MATERIALS AND METHODS: In total, 59 orthodontic patients (21 males and 38 females) from three orthodontic clinics participated in this 2-arm, parallel-group clinical trial and were randomized to 0.014″ A-NiTi (n=30) or 0.016″ HANT groups (n=29). Patient recruitment commenced in April 2016 and ended in December 2016...
February 22, 2018: International Orthodontics
Charles Feldman, Marcela Boro Veiros, Tonya McGill
No abstract text is available yet for this article.
March 2018: Perspectives in Public Health
Stefanie Kennon-McGill, Mitchell R McGill
Research on acetaminophen (APAP) toxicity over the last several decades has focused on the pathophysiology of liver injury, but increasing attention is being paid to other known and possible adverse effects. It has been known for decades that APAP causes acute kidney injury, but confusion exists regarding prevalence, and the mechanisms have not been well investigated. More recently, a number of experimental, clinical and epidemiological studies have reported evidence for pulmonary, endocrine, neurological and neurodevelopmental toxicity, but the quality of evidence from those studies varies...
January 15, 2018: Journal of Clinical and Translational Research
Hirotaka Nishiyama, Shinpei Tanaka, Reina Nemoto, Hiroyuki Miura, Kazuyoshi Baba
PURPOSE: This study introduces a newly developed zirconia complete denture (ZrD) that incorporates a ceria-stabilized zirconia/alumina nano-composite framework fabricated with computer-aided design/computer-aided manufacture (CAD/CAM). MATERIALS AND METHODS: Twenty-nine edentulous patients received either a maxillary ZrD (n = 10) or a maxillary conventional complete denture (CD) (n = 19). Patient satisfaction was evaluated before and 12 months after prosthesis placement using the McGill Denture Satisfaction Instrument...
February 15, 2018: International Journal of Prosthodontics
Jodi L McGill, Sean M Kelly, Pankaj Kumar, Savannah Speckhart, Shannon L Haughney, Jamie Henningson, Balaji Narasimhan, Randy E Sacco
Human respiratory syncytial virus (HRSV) is a leading cause of severe acute lower respiratory tract infection in infants and children worldwide. Bovine RSV (BRSV) is closely related to HRSV and a significant cause of morbidity in young cattle. BRSV infection in calves displays many similarities to RSV infection in humans, including similar age dependency and disease pathogenesis. Polyanhydride nanoparticle-based vaccines (i.e., nanovaccines) have shown promise as adjuvants and vaccine delivery vehicles due to their ability to promote enhanced immunogenicity through the route of administration, provide sustained antigen exposure, and induce both antibody- and cell-mediated immunity...
February 14, 2018: Scientific Reports
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