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https://www.readbyqxmd.com/read/29779126/animal-models-of-chronic-migraine
#1
REVIEW
Tse-Ming Chou, Shih-Pin Chen
PURPOSE OF REVIEW: Chronic migraine (CM) is a recalcitrant subtype of migraine which causes high degrees of disability, poor treatment responses, and frequent recurrences in sufferers. However, the pathophysiological mechanisms underlying the development and chronification of migraine attacks remain incompletely understood. A validated animal model could help to decipher the pathogenic mechanism of the disease, facilitating the development of possible therapeutic strategies for CM. In this review, we aimed to summarize current animal models of CM and discuss the validity of these models...
May 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29771142/the-development-of-a-mouse-model-of-mtbi-induced-post-traumatic-migraine-and-identification-of-the-delta-opioid-receptor-as-a-novel-therapeutic-target
#2
Laura S Moye, Madeline L Novack, Alycia F Tipton, Harish Krishnan, Subhash C Pandey, Amynah Aa Pradhan
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Methods We combined the closed head weight-drop method and the nitroglycerin chronic migraine model...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29771141/headache-comorbidities-and-lifestyle-in-an-adolescent-population-the-teens-study
#3
Marta Torres-Ferrus, Carme Vila-Sala, Manuel Quintana, Sara Ajanovic, Victor José Gallardo, Juan Bernardo Gomez, José Alvarez-Sabin, Alfons Macaya, Patricia Pozo-Rosich
Objective To evaluate the prevalence and characteristics of headache and its relationship with comorbidities and lifestyle in a teenage population. Methods This is a cross-sectional study. Data was collected from students aged 12-18 years from six different schools in Catalonia, Spain. They completed an anonymous questionnaire with demographic, lifestyle, medical data, presence of recurrent headaches and its features, and completed the Strengths and Difficulties Questionnaire. We defined probable migraine if headache presented ≥ 3 ICHD-3 beta criteria for migraine...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29767791/noninvasive-vagal-nerve-stimulation-in-chronic-migraine-with-medication-overuse-headache
#4
Alessandro Vacca, Annalisa Gai, Flora Govone, Elisa Rubino, Paola De Martino, Salvatore Gentile, Lorenzo Pinessi, Innocenzo Rainero
No abstract text is available yet for this article.
May 14, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29762872/the-effect-of-onabotulinumtoxina-on-aura-frequency-and-severity-in-patients-with-hemiplegic-migraine-case-series-of-11-patients
#5
Tiffany Y Chen, Ivan Garza, David W Dodick, Carrie E Robertson
BACKGROUND: OnabotulinumtoxinA has been demonstrated to be effective for the preventive treatment of headache in individuals with chronic migraine and has been approved and recommended for this patient population. While the therapeutic effect of onabotulinumtoxinA on migraine headache is well documented, there is limited information on the effect of onabotulinumtoxinA on migraine aura. OBJECTIVE: Given the prolonged and often debilitating nature of aura in patients with hemiplegic migraine, our group sought to examine the effect of onabotulinumtoxinA on aura frequency and severity in this specific subset of migraine patients...
May 15, 2018: Headache
https://www.readbyqxmd.com/read/29762446/prospective-analysis-of-the-greater-occipital-nerve-location-in-patients-undergoing-occipital-nerve-decompression
#6
Jacqueline S Israel, Steve J Kempton, Ahmed M Afifi
BACKGROUND: Migraine surgery and onabotulinumtoxinA injections aim to deactivate neurovascular trigger points implicated in chronic headaches. The greater occipital nerve (GON) is a common trigger point. The depth of this nerve has not been previously described. The purpose of this study was to report the intraoperative location, including depth, of the GON in human subjects undergoing migraine surgery. METHODS: We reviewed records of patients who underwent GON decompression by a single surgeon...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29752991/cerebrolysin-attenuates-hyperalgesia-photophobia-and-neuroinflammation-in-a-nitroglycerin-induced-migraine-model-in-rats
#7
Javad Mahmoudi, Gisou Mohaddes, Marjan Erfani, Saeed Sadigh-Eteghad, Pouran Karimi, Mojgan Rajabi, Siamak Reyhani-Rad, Fereshteh Farajdokht
Chronic migraine dramatically affects the quality of life in the migraineurs. This study examined the effect of chronic cerebrolysin (CBL) treatment on the migraine-associated symptoms in a rat model of migraine. Experiments were carried out on 8 weeks, male Wistar rats. Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9. CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days. Mechanical and thermal withdrawal thresholds of the hind paw were examined by von Frey hairs and hot plate, respectively...
May 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29746011/medication-overuse-headache-detoxification-reduces-headache-disability-the-akershus-study-of-chronic-headache
#8
Espen Saxhaug Kristoffersen, Ragnhild Berling Grande, Kjersti Aaseth, Michael Bjørn Russell, Christofer Lundqvist
BACKGROUND: Medication-overuse headache (MOH) is a chronic headache (≥ 15 days/month) associated with overuse of acute headache medication. The objective was to investigate headache-related disability before and after self-detoxification from MOH in the general population, as well as possible predictors for successful outcome. METHODS: A prospective cohort study. Participants were identified in a cross-sectional epidemiological sample of 30 000 persons aged 30-44 from the general Norwegian population...
May 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29742066/endoscopic-management-of-recurrent-tracheoesophageal-fistula-induced-by-chronic-use-of-nonsteroidal-anti-inflammatory-drugs-a-case-report-and-review-of-the-literature
#9
Theodor Alexandru Voiosu, Andrada Viorela Gheorghe, Dan Adrian Bobeica, Andrei Mihai Voiosu, Radu Bogdan Mateescu
Tracheoesophageal fistula (TEF) is frequently congenital and requires surgical correction. TEF can also occur secondary to malignant esophageal tumors or benign diseases and these cases are managed by endoscopic means, such as closing the defect with metallic stents. Although esophageal injury can occur secondary to nonsteroidal anti-inflammatory drugs (NSAIDs), TEF secondary to chronic NSAIDs use hasn't been described in the literature. We report the case of a male patient with refractory migraine and chronic use of NSAIDs, with a history of esophageal stenosis presenting with acute-onset total dysphagia...
May 8, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29737529/posttraumatic-headache-classification-by-symptom-based-clinical-profiles
#10
Sylvia Lucas, Andrew H Ahn
There are currently no accepted therapies for posttraumatic headache (PTH). In order to meet the urgent need for effective therapies for PTH, we must continue to address fundamental gaps in our understanding of the clinical course and impact of PTH. Here we examine the existing schema used to characterize the clinical characteristics of PTH, including the International Classification of Headache Disorders (ICHD). There remain unresolved questions about whether to classify patients based on the extent of brain injury or on clinical symptom profiles...
May 8, 2018: Headache
https://www.readbyqxmd.com/read/29736227/molecular-mechanisms-of-omega-3-fatty-acids-in-the-migraine-headache
#11
REVIEW
Neda Soveyd, Mina Abdolahi, Sama Bitarafan, Abbas Tafakhori, Payam Sarraf, Mansoureh Togha, Ali Asghar Okhovat, Mahsa Hatami, Mohsen Sedighiyan, Mahmoud Djalali, Niyaz Mohammadzadeh Honarvar
Migraine is a common chronic inflammatory neurological disease with the progressive and episodic course. Much evidence have shown a role of inflammation in the pathogenesis of migraine. Omega-3 fatty acids are an important components of cell membranes phospholipids. The intake of these fatty acids is related to decrease concentration of C-reactive protein (CRP), proinflammatory eicosanoids, cytokines, chemokines and other inflammation biomarkers. Many of clinical trials have shown the beneficial effect of dietary supplementation with omega-3 fatty acids in inflammatory and autoimmune diseases in human, including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), multiple sclerosis (MS) and migraine headaches...
October 7, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/29736067/mix-headache-a-valid-clinical-entity
#12
Tapas Kumar Aich, Uttam Gupta, Sandip Subedi
Background: Chronic daily headache (CDH) patients respond better with a combination of anti-migraine and anti-stress medications, irrespective of clinical diagnosis of chronic migraine (CM) or chronic tension-type headache (CTTH). Hypothesis: "CDH: Mix headache" type is a valid clinical entity. Materials and Methods: A total of 70 participants fulfilling the diagnosis of "primary CDH", aged between 15 and 55 years were taken up for the present study...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29733088/pediatric-abdominal-migraine-current-perspectives-on-a-lesser-known-entity
#13
REVIEW
Jyoti Mani, Shailender Madani
Background: Abdominal migraine (AM) is a common cause of chronic and recurrent abdominal pain in children. It is characterized by paroxysms of moderate to severe abdominal pain that is midline, periumbilical, or diffuse in location and accompanied by other symptoms including headache, anorexia, nausea, vomiting, or pallor. Despite the presence of comprehensive diagnostic criteria under Rome IV classification of functional gastrointestinal disorders (FGIDs) and International Classification of Headache Disorders, it continues to be an underdiagnosed entity...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29732536/cognitive-behavioral-therapy-for-insomnia-to-reduce-chronic-migraine-a-sequential-bayesian-analysis
#14
REVIEW
Todd A Smitherman, Alexander J Kuka, Anne H Calhoun, A Brooke Pellegrino Walters, Rachel E Davis-Martin, Carrie E Ambrose, Jeanetta C Rains, Timothy T Houle
BACKGROUND: Insomnia is frequently comorbid with chronic migraine, and small trials suggest that cognitive-behavioral treatment of insomnia (CBTi) may reduce migraine frequency. This study endeavored to provide a quantitative synthesis of existing CBTi trials for adults with chronic migraine using Bayesian statistical methods, given their utility in combining prior knowledge with sequentially gathered data. METHODS: Completer analyses of 2 randomized trials comparing CBTi to a sham control intervention (Calhoun and Ford, 2007; Smitherman et al, 2016) were used to quantify the effects of a brief course of treatment on headache frequency...
May 6, 2018: Headache
https://www.readbyqxmd.com/read/29727478/assessing-physician-patient-dialogues-about-chronic-migraine-during-routine-office-visits
#15
Dawn C Buse, Patrick Gillard, Kaitlyn Arctander, Amy W Kuang, Richard B Lipton
OBJECTIVE: To assess physician-patient communication and identify the frequency of use of specific communication techniques by analyzing recordings of routinely scheduled medical encounters for patients with clinician-identified chronic migraine. BACKGROUND: Chronic migraine is an under-diagnosed, under-treated, and highly burdensome disease. Effective medical communication is integral to optimal medical care, including providing accurate diagnoses, creating effective treatment plans, and enhancing patient adherence...
May 4, 2018: Headache
https://www.readbyqxmd.com/read/29727473/can-circadian-dysregulation-exacerbate-migraines
#16
REVIEW
Jason C Ong, Hannah L Taylor, Margaret Park, Helen J Burgess, Rina S Fox, Sarah Snyder, Jeanetta C Rains, Colin A Espie, James K Wyatt
OBJECTIVE: This observational pilot study examined objective circadian phase and sleep timing in chronic migraine (CM) and healthy controls (HC) and the impact of circadian factors on migraine frequency and severity. BACKGROUND: Sleep disturbance has been identified as a risk factor in the development and maintenance of CM but the biological mechanisms linking sleep and migraine remain largely theoretical. METHODS: Twenty women with CM and 20 age-matched HC completed a protocol that included a 7 day sleep assessment at home using wrist actigraphy followed by a circadian phase assessment using salivary melatonin...
May 4, 2018: Headache
https://www.readbyqxmd.com/read/29722276/sustained-reductions-in-migraine-days-moderate-to-severe-headache-days-and-days-with-acute-medication-use-for-hfem-and-cm-patients-taking-fremanezumab-post-hoc-analyses-from-phase-2-trials
#17
Rashmi B Halker Singh, Ernesto Aycardi, Marcelo E Bigal, Pippa S Loupe, Mirna McDonald, David W Dodick
Background In phase 2 and 3 studies, fremanezumab, a monoclonal CGRP antibody, was an effective preventive treatment for high-frequency episodic migraine (HFEM) and chronic migraine (CM). Objective Post-hoc analyses evaluated population-wise 50%, 75% and 100% responder rates, and the extent to which individual responders sustained a 50%, 75% and 100% reduction in migraine days, moderate-to-severe (M/S) headache days and days of acute medication use during all three treatment months of the fremanezumab phase 2 studies...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29720815/hemicrania-continua
#18
REVIEW
Sanjay Prakash, Bansi Adroja
Hemicrania continua (HC) is an indomethacin responsive primary chronic headache disorder which is currently classified as a subtype of trigeminal autonomic cephalalgias (TACs). It is not very uncommon. There are >1000 cases of HC in the literature, and it constitutes 1.7% of total headache in the clinic settings. Misdiagnosis for HC is very common at all clinical settings. A diagnosis of HC is missed even by neurologists and headache specialists. It is characterized by a continuous strictly unilateral headache with superimposed exacerbations...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29710791/using-sleep-time-data-from-wearable-sensors-for-early-detection-of-migraine-attacks
#19
Pekka Siirtola, Heli Koskimäki, Henna Mönttinen, Juha Röning
The migraine is a chronic, incapacitating neurovascular disorder, characterized by attacks of severe headache and autonomic nervous system dysfunction. Among the working age population, the costs of migraine are 111 billion euros in Europe alone. The early detection of migraine attacks would reduce these costs, as it would shorten the migraine attack by enabling correct timing when taking preventive medication. In this article, whether it is possible to detect migraine attacks beforehand using wearable sensors is studied, and t preliminary results about how accurate the recognition can be are provided...
April 28, 2018: Sensors
https://www.readbyqxmd.com/read/29703770/visual-stimulation-leads-to-activation-of-the-nociceptive-trigeminal-nucleus-in-chronic-migraine
#20
Laura H Schulte, Angie Allers, Arne May
OBJECTIVE: The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level of the brainstem might lead to enhanced activity within the spinal trigeminal nucleus (sTN) as the main site of trigeminal pain processing within this area. METHODS: Eighteen episodic migraineurs (EM), 17 chronic migraineurs (CM), and 19 healthy controls (HC) underwent one session of high-resolution brainstem imaging during which a rotating checkerboard was presented repeatedly as a visual stimulus...
April 27, 2018: Neurology
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