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https://www.readbyqxmd.com/read/28933107/-research-progress-of-chemical-constituents-and-pharmacological-activities-of-essential-oil-of-ligusticum-chuanxiong
#1
REVIEW
Jing-Chang Du, Xiao-Fang Xie, Liang Xiong, Chen Sun, Cheng Peng
Essential oil is the low polar and volatile components distilled or extracted from Ligusticum chuanxiong, the dry root of perennial herb L. chuanxiong, which has proven to be one of the main biological active ingredients of L. chuanxiong. Studies suggested that essential oil of L. chuanxiong mainly contains phthalide, terpene alcohols and fatty acids compounds. Different regions or varied extraction technology had influences on the type and contents of compound in essential oil of L. chuanxiong and the total yield efficiency of essential oil, while the differences among the distribution of compounds leads to the variant pharmacological function of essential oil of L...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932372/acupuncture-and-botulinum-toxin-a-injection-in-the-treatment-of-chronic-migraine-a-randomized-controlled-study
#2
Bahram Naderinabi, Alia Saberi, Masood Hashemi, Mohammad Haghighi, Gelareh Biazar, Farid Abolhasan Gharehdaghi, Abbas Sedighinejad, Tahereh Chavoshi
BACKGROUND: Migraine is a common type of headache. Sometimes adequate pain relief is not achieved by conventional treatments. Acupuncture and botulinum toxin-A injection are known as non-pharmacological interventions for this purpose. The aim of this research was to compare the effect of acupuncture with botulinum toxin-A injection and pharmacological treatment in controlling chronic migraine. METHODS: This clinical trial was conducted on patients with chronic migraine in the North of Iran during 2014-2015...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28922461/the-role-of-leptin-as-a-biomarker-in-the-relationship-between-periodontitis-and-chronic-migraine
#3
Yago Leira, Pablo Ameijeira, Clara Domínguez, Rogelio Leira, Juan Blanco
AIM: To evaluate the prevalence of periodontitis (CP) and its contribution to serum leptin levels in chronic migraine (CM). MATERIAL AND METHODS: In this case-control study, we included 150 subjects divided into healthy controls (n=58) and CM patients (n=92). Demographic, neurological, clinical data as well as full-mouth periodontal records were obtained. Serum leptin levels were measured by ELISA technique. RESULTS: Both the prevalence of CP and mean serum leptin levels were significantly higher in patients with CM in comparison to controls (57...
September 18, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28920449/the-relationship-between-migraine-and-rosacea-systematic-review-and-meta-analysis
#4
Casper Emil Christensen, Frederikke Schelde Andersen, Nita Wienholtz, Alexander Egeberg, Jacob P Thyssen, Messoud Ashina
Objective To systematically review the association between migraine and rosacea. Background Migraine is a complex disorder with episodes of headache, nausea, photo- and phonophobia. Rosacea is an inflammatory skin condition with flushing, erythema, telangiectasia, papules, and pustules. Both are chronic disorders with exacerbations of symptoms almost exclusively in areas innervated by the trigeminal nerve. Previous studies found an association between these disorders. We review these findings, provide a meta-analysis, and discuss possible pathophysiological commonalities...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28920448/assessing-the-impact-of-headaches-and-the-outcomes-of-treatment-a-systematic-review-of-patient-reported-outcome-measures-proms
#5
Kirstie L Haywood, Tom S Mars, Rachel Potter, Shilpa Patel, Manjit Matharu, Martin Underwood
Aims To critically appraise, compare and synthesise the quality and acceptability of multi-item patient reported outcome measures for adults with chronic or episodic headache. Methods Systematic literature searches of major databases (1980-2016) to identify published evidence of PROM measurement and practical properties. Data on study quality (COSMIN), measurement and practical properties per measure were extracted and assessed against accepted standards to inform an evidence synthesis. Results From 10,903 reviewed abstracts, 103 articles were assessed in full; 46 provided evidence for 23 PROMs: Eleven specific to the health-related impact of migraine (n = 5) or headache (n = 6); six assessed migraine-specific treatment response/satisfaction; six were generic measures...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28913825/a-nursing-intervention-increases-quality-of-life-and-self-efficacy-in-migraine-a-1-year-prospective-controlled-trial
#6
Elizabeth Leroux, Line Beaudet, Guy Boudreau, Marzieh Eghtesadi, Luc Marchand, Heather Pim, Miguel Chagnon
OBJECTIVES: To compare the impact of a combined nursing and medical approach to a medical follow-up only on headache outcomes, quality of life, and self-efficacy in a cohort of migraineurs. BACKGROUND: Interdisciplinary approaches have been proposed for migraine management. A nursing intervention could improve patient outcomes. METHODS: We prospectively studied new patients referred to our tertiary headache center for migraine. The control group was followed by a physician; the active group was also followed by a nurse with a personalized intervention including adaptation of the lifestyle...
September 15, 2017: Headache
https://www.readbyqxmd.com/read/28901169/predictors-of-response-to-occipital-nerve-stimulation-in-refractory-chronic-headache
#7
Sarah Miller, Laurence Watkins, Manjit Matharu
Background Occipital nerve stimulation is a promising treatment for refractory chronic headache disorders, but is invasive and costly. Identifying predictors of response would be useful in selecting patients. We present the results of an open-label prospective cohort study of 100 patients (35 chronic migraine, 33 chronic cluster headache, 20 short-lasting unilateral neuralgiform headache attacks and 12 hemicrania continua) undergoing occipital nerve stimulation, using a multivariate binary regression analysis to identify predictors of response...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28899205/non-invasive-vagus-nerve-stimulation-for-the-management-of-refractory-primary-chronic-headaches-a-real-world-experience
#8
Michele Trimboli, Adnan Al-Kaisy, Anna P Andreou, Madeleine Murphy, Giorgio Lambru
Background Non-invasive vagus nerve stimulation has initial evidence of efficacy in migraine and cluster headache. However, little is known about its role in the management of refractory chronic headaches. Methods We evaluated the preventive and abortive effects of non-invasive vagus nerve stimulation in 41 consecutive patients with refractory primary chronic headaches in an open-label prospective clinical audit. Headache diaries were used to collect clinical information. Those who obtained at least 30% reduction in headache days/episodes after three months of treatment were considered responders and were offered treatment continuation...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28895657/identifying-psychogenic-seizures-through-comorbidities-and-medication-history
#9
Wesley T Kerr, Emily A Janio, Chelsea T Braesch, Justine M Le, Jessica M Hori, Akash B Patel, Norma L Gallardo, Janar Bauirjan, Shannon R D'Ambrosio, Andrea M Chau, Eric S Hwang, Emily C Davis, Albert Buchard, David Torres-Barba, Mona Al Banna, Sarah E Barritt, Andrew Y Cho, Jerome Engel, Mark S Cohen, John M Stern
OBJECTIVE: Low-cost evidence-based tools are needed to facilitate the early identification of patients with possible psychogenic nonepileptic seizures (PNES). Prior to accurate diagnosis, patients with PNES do not receive interventions that address the cause of their seizures and therefore incur high medical costs and disability due to an uncontrolled seizure disorder. Both seizures and comorbidities may contribute to this high cost. METHODS: Based on data from 1,365 adult patients with video-electroencephalography-confirmed diagnoses from a single center, we used logistic and Poisson regression to compare the total number of comorbidities, number of medications, and presence of specific comorbidities in five mutually exclusive groups of diagnoses: epileptic seizures (ES) only, PNES only, mixed PNES and ES, physiologic nonepileptic seizurelike events, and inconclusive monitoring...
September 12, 2017: Epilepsia
https://www.readbyqxmd.com/read/28886861/primary-headache-disorders-part-2-tension-type-headache-and-medication-overuse-headache
#10
Gary W Jay, Robert L Barkin
In Part 2 of Primary Headache disorders, we discuss the fourth Primary Headache Disorder, Tension-Type Headache (TTHA). We are again using the ICHD-III (Beta) definitions of such headaches, taking into consideration episodic and chronic TTHA, as well as the presence or absence of pericranial muscle tenderness. We discuss the pathophysiology and pharmacotherapeutic treatment of TTHA, and the aspects of the Myofascial Pain Syndrome that enhance and help the development of TTHA. We then discuss Medication Overuse Headache (MOH), itself a Secondary headache disorder, but one that is extremely important as it assists with the chronification of both migraine and TTHA...
September 5, 2017: Disease-a-month: DM
https://www.readbyqxmd.com/read/28886662/comment-on-relationship-between-serum-levels-of-vip-but-not-of-cgrp-and-cranial-autonomic-parasympathetic-symptoms-a-study-in-chronic-migraine-patients
#11
Hyun Jin Min, Kyung Soo Kim
No abstract text is available yet for this article.
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28886661/comment-on-excessive-daytime-sleepiness-in-chronic-migraine-and-chronic-tension-type-headache-from-the-general-population
#12
Hyun Jin Min, Kyung Soo Kim
No abstract text is available yet for this article.
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28884716/-efficacy-of-different-doses-of-botox-in-treatment-of-chronic-migraine
#13
M V Naprienko, L V Smekalkina, E A Surnova
AIM: To compare the efficacy of botox used in doses of 155 U and 195 U for preventive treatment of chronic migraine (CM). MATERIAL AND METHODS: Thirty-nine women with CM were stratified into two groups according to the dose of botox. The duration of the study was 9 month, patient's state was assessed before treatment and after repeated injections (every 3 month). RESULTS AND CONCLUSION: With regard to the frequency of migraine attacks, the 1st and 2nd injections of botox were equally effective...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28879545/real-life-use-of-onabotulinumtoxina-for-symptom-relief-in-patients-with-chronic-migraine-repose-study-methodology-and-baseline-data
#14
Brendan Davies, Charly Gaul, Paolo Martelletti, Juan Carlos García-Moncó, Stephanie Brown
BACKGROUND: Migraine is a debilitating neurological disorder that affects 14.1% of the US and 14.7% of the European populations. Chronic migraine (CM) is broadly defined as headache occurring on ≥15 days per month for ≥3 months, and has an estimated worldwide prevalence of 1.4% to 2.2%. OnabotulinumtoxinA is currently approved for the treatment of CM in most European countries, and is the only preventative treatment approved for adults with CM, based on results from the PREEMPT clinical trial programme...
September 6, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28877509/botulinum-toxin-for-chronic-migraine-clinical-trials-and-technical-aspects
#15
Cristina Tassorelli, Grazia Sances, Micol Avenali, Roberto De Icco, Daniele Martinelli, Vito Bitetto, Giuseppe Nappi, Giorgio Sandrini
OnabotulinumtoxinA has been approved for the prophylaxis of chronic migraine following the demonstration of efficacy in two large controlled trials. Data collected from pragmatic studies in the real-life setting have contributed important additional information that are extremely useful for the management of this group of extremely disabled and challenging patients. The main findings from these studies are presented and discussed.
September 3, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28870085/a-systematic-review-and-critical-appraisal-of-gene-polymorphism-association-studies-in-medication-overuse-headache
#16
Sarah Cargnin, Michele Viana, Grazia Sances, Cristina Tassorelli, Salvatore Terrazzino
Purpose of review Medication-overuse headache is a secondary chronic headache disorder, evolving from an episodic primary headache type, caused by the frequent and excessive use of headache symptomatic drugs. While gene polymorphisms have been deeply investigated as susceptibility factors for migraine, little attention has been paid to medication-overuse headache genetics. In the present study we conducted a systematic review to identify, appraise and summarize the current findings of gene polymorphism association studies in medication-overuse headache...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28862758/fremanezumab-as-add-on-treatment-for-patients-treated-with-other-migraine-preventive-medicines
#17
Joshua M Cohen, David W Dodick, Ronghua Yang, Lawrence C Newman, Thomas Li, Ernesto Aycardi, Marcelo E Bigal
BACKGROUND: Fremanezumab (formerly TEV-48125) is a monoclonal antibody directed against calcitonin-gene-related peptide (CGRP), a validated target for migraine preventive therapy. In two previous phase 2 studies, fremanezumab administered once every 28 days for 12 weeks was found to be effective and safe as a preventive treatment for patients suffering from episodic migraine (EM) and chronic migraine (CM). OBJECTIVE: To evaluate the efficacy and safety of fremanezumab as an add-on preventive therapy in individuals with EM and CM who are on stable doses of preventive migraine medications...
September 1, 2017: Headache
https://www.readbyqxmd.com/read/28857154/psychometric-evaluation-of-a-novel-instrument-assessing-the-impact-of-migraine-on-physical-functioning-the-migraine-physical-function-impact-diary
#18
Ariane K Kawata, Ray Hsieh, Randall Bender, Shannon Shaffer, Dennis A Revicki, Martha Bayliss, Dawn C Buse, Pooja Desai, Sandhya Sapra, Brian Ortmeier, Asha Hareendran
OBJECTIVE: The objective of this study was to evaluate the measurement properties of the Migraine Physical Function Impact Diary (MPFID), a novel patient-reported outcome (PRO) measure for assessing the impact of migraine on physical functioning. METHODS: In a prospective, observational study, adults with episodic migraine (EM) or chronic migraine (CM) used an eDiary to complete the MPFID (assessing daily impacts of migraine on physical function) and a headache diary (capturing migraine days, migraine pain intensity, and migraine interference) each day, and other PRO instruments related to migraine...
August 30, 2017: Headache
https://www.readbyqxmd.com/read/28856912/roller-pressure-algometry-as-a-new-tool-for-assessing-dynamic-pressure-sensitivity-in-migraine
#19
Ángel L Guerrero-Peral, Marina Ruíz, Johanna Barón, María Palacios-Ceña, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
Objectives To explore the validity of the roller pressure algometer as a new tool for evaluating dynamic pressure sensitivity by assessing its association with pain features and widespread pressure pain sensitivity in migraine women, and also to determine whether dynamic pressure algometry differentiates between episodic and chronic migraine. Methods One hundred and twenty women with migraine (42% chronic, 58% episodic) participated. Dynamic pressure sensitivity was assessed with a set of roller pressure algometers (Aalborg University, Denmark®) consisting of 11 rollers with fixed pressure levels from 500 to 5300 g...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28854909/a-combination-of-coenzyme-q10-feverfew-and-magnesium-for-migraine-prophylaxis-a-prospective-observational-study
#20
Angèle Guilbot, Marie Bangratz, Samira Ait Abdellah, Christian Lucas
BACKGROUND: Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in an observational study. METHODS: Adult patients suffering from migraine according to the criteria of the International Headache Society were enrolled by general practitioners (≥2 migraine attacks during previous month; exclusion of chronic migraine and medication overuse) and after a one-month baseline phase, supplemented with one tablet of 100 mg feverfew, 100 mg coenzyme Q10 and 112...
August 30, 2017: BMC Complementary and Alternative Medicine
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