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Lazy eye (amblyopia)

Joshua D Stein, Chris Andrews, David C Musch, Carmen Green, Paul P Lee
Sight-threatening eye diseases such as strabismus (misaligned eyes) and amblyopia (lazy eye) develop during childhood. The earlier in life these diseases are diagnosed and effectively treated, the greater the chance of preventing irreversible long-term sight loss. Using 2001-14 claims data for nearly 900,000 US children with health insurance, we followed a cohort for up to fourteen years from birth, to assess whether household net worth affected rates of visits to ophthalmologists and optometrists or rates of diagnoses of strabismus and amblyopia...
August 1, 2016: Health Affairs
Elizabeth S van de Graaf, Dominiek D G Despriet, Caroline C W Klaver, Huibert J Simonsz
BACKGROUND: Utility of visual impairment caused by amblyopia is important for the cost-effectiveness of screening for amblyopia (lazy eye, prevalence 3-3.5 %). We previously measured decrease of utility in 35-year-old persons with unilateral persistent amblyopia. The current observational case-control study aimed to measure loss of utility in patients with amblyopia with recent decrease of vision in their better eye. As these patients are rare, the sample was supplemented by patients with bilateral age-related macular degeneration with similar decrease of vision...
2016: BMC Ophthalmology
Roberto Perilli, Modesto Lanci, Antonino Romanzo, Laura Sabatini, Paola Fusilli
INTRODUCTION: Visual performance of eyes with congenital pathologies is conditioned by an early diagnosis. Families having problems in accessing health services risk to delay or miss both an early diagnosis and an early treatment and amblyopia (lazy eye) prevention. METHODS: In our hospital, all full-term, healthy newborns are thoroughly examined by an ophthalmologist in the maternal ward, 1 to 3 days after birth. RESULTS: Among the first 5000 newborns examined, a high incidence of congenital pathologies compared to international literature was reported, with differences between Caucasians and non-Caucasians...
2015: Annali Dell'Istituto Superiore di Sanità
Frank Sengpiel
Over the last 50 years, research into the developmental plasticity of the visual cortex has led to a growing understanding of first the causes and then of the underlying cellular mechanisms of amblyopia or 'lazy eye', the commonest childhood disorder of vision. While it is widely believed that amblyopia cannot be treated successfully after the age of about 7, recent animal studies have demonstrated that visual cortex plasticity can be restored or enhanced later in life, paving the way for new strategies for the treatment of amblyopia that attempt to remove molecular brakes on plasticity...
September 22, 2014: Current Biology: CB
Alex R Kemper, John E Crews, Bonnie Strickland, Jinan B Saaddine
No abstract text is available yet for this article.
September 12, 2014: MMWR Supplements
Lisa Jones-Jordan, Xue Wang, Roberta W Scherer, Donald O Mutti
BACKGROUND: Hyperopia (far-sightedness) in infancy requires accommodative effort to bring images into focus. Prolonged accommodative effort has been associated with an increased risk of strabismus (eye misalignment). Strabismus makes it difficult for the eyes to work together and may result in symptoms of asthenopia (eye strain) and intermittent diplopia (double vision), and makes near work tasks difficult to complete. Untreated strabismus may result in the development of amblyopia (lazy eye)...
2014: Cochrane Database of Systematic Reviews
Maria Fronius, Licia Cirina, Hanns Ackermann, Thomas Kohnen, Corinna M Diehl
The notion of a limited, early period of plasticity of the visual system has been challenged by more recent research demonstrating functional enhancement even into adulthood. In amblyopia ("lazy eye") it is still unclear to what extent the reduced effect of treatment after early childhood is due to declining plasticity or lower compliance with prescribed patching. The aim of this study was to determine the dose-response relationship and treatment efficiency from acuity gain and electronically recorded patching dose rates, and to infer from these parameters on a facet of age dependence of functional plasticity related to occlusion for amblyopia...
October 2014: Vision Research
Kristina Irsch, Boris I Gramatikov, Yi-Kai Wu, David L Guyton
Amblyopia ("lazy eye") is a major public health problem, caused by misalignment of the eyes (strabismus) or defocus. If detected early in childhood, there is an excellent response to therapy, yet most children are detected too late to be treated effectively. Commercially available vision screening devices that test for amblyopia's primary causes can detect strabismus only indirectly and inaccurately via assessment of the positions of external light reflections from the cornea, but they cannot detect the anatomical feature of the eyes where fixation actually occurs (the fovea)...
June 2014: Journal of Biomedical Optics
Elena Avram, Adriana Stănilă
Amblyopia is a disorder of the visual system that represents unilateral or bi-lateral reduction of visual acuity in which an organic cause cannot be detected. The illness represents a syndrome of visual deficits, not only a deterioration of visual acuity. This syndrome includes: presence of crowding phenomena, contrast sensitivity deterioration, deficits in accommodation, deterioration of spatial orientation and ocular motility dysfunction. Depending on its etiology, amblyopia is classified into four main types: strabismic amblyopia, anisometropic amblyopia, isoametropic amblyopia and stimulus deprivation amblyopia...
2013: Oftalmologia
Elena Avram, Adriana Stănilă
Amblyopia or "lazy eye" represents a disorder of the visual system characterized by poor vision in an eye that is otherwise physically normal. Anisometropia, the condition in which the two eyes have an unequal refractive error, is considered the second most common cause of amblyopia. The purpose of this study is to determine the efficiency of HTS Amblyopia iNet Software by studying the progress of visual acuity, contrast sensitivity and stereopsis vision in anisometropic amblyopic children. 5 patients (age: 5-13 years), treated with HTS Amblyopia iNet Software at OftaTotal Clinic from Sibiu, between 2010-2013, participated in this clinical trial...
2013: Oftalmologia
Brendan T Barrett, Gurvinder K Panesar, Andrew J Scally, Ian E Pacey
BACKGROUND: Adults with amblyopia ('lazy eye'), long-standing strabismus (ocular misalignment) or both typically do not experience visual symptoms because the signal from weaker eye is given less weight than the signal from its fellow. Here we examine the contribution of the weaker eye of individuals with strabismus and amblyopia with both eyes open and with the deviating eye in its anomalous motor position. METHODOLOGY/RESULTS: The task consisted of a blue-on-yellow detection task along a horizontal line across the central 50 degrees of the visual field...
2013: PloS One
Agnes M F Wong
No abstract text is available yet for this article.
March 4, 2014: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Alexander J Foss, Richard M Gregson, Daisy MacKeith, Nicola Herbison, Isabel M Ash, Sue V Cobb, Richard M Eastgate, Trish Hepburn, Anthony Vivian, Diane Moore, Stephen M Haworth
BACKGROUND: Amblyopia (lazy eye) affects the vision of approximately 2% of all children. Traditional treatment consists of wearing a patch over their 'good' eye for a number of hours daily, over several months. This treatment is unpopular and compliance is often low. Therefore results can be poor. A novel binocular treatment which uses 3D technology to present specially developed computer games and video footage (I-BiT™) has been studied in a small group of patients and has shown positive results over a short period of time...
2013: Trials
Frank Sengpiel
For over a hundred years, patching of the good eye has been the main and often only method of treating a 'lazy' or amblyopic eye. A recent study shows that a period of time in complete darkness can promote rapid recovery of vision.
March 4, 2013: Current Biology: CB
Xiaoming Lin, Kun Ding, Yong Liu, Xiaohe Yan, Shaojie Song, Tianzi Jiang
Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia...
2012: PloS One
Ewa Niechwiej-Szwedo, Herbert C Goltz, Manokaraananthan Chandrakumar, Agnes M F Wong
BACKGROUND: Impairment of spatiotemporal visual processing in amblyopia has been studied extensively, but its effects on visuomotor tasks have rarely been examined. Here, we investigate how visual deficits in amblyopia affect motor planning and online control of visually-guided, unconstrained reaching movements. METHODS: Thirteen patients with mild amblyopia, 13 with severe amblyopia and 13 visually-normal participants were recruited. Participants reached and touched a visual target during binocular and monocular viewing...
2012: PloS One
V Sturm
Amblyopia is a condition of decreased monocular or binocular visual acuity caused by form deprivation or abnormal binocular interaction. Amblyopia is the most common cause of monocular vision loss in children with a prevalence of 2 to 5%. During the last decade, several prospective randomized studies have influenced our clinical management. Based on these studies, optimum refractive correction should be prescribed first. However, most patients will need additional occlusion therapy which is still considered the «gold standard» of amblyopia management...
February 16, 2011: Praxis
Robert F Hess, Benjamin Thompson, Glen A Gole, Kathy T Mullen
Amblyopia or lazy eye is the most common cause of uniocular blindness in adults and is caused by a disruption to normal visual development as a consequence of unmatched inputs from the two eyes in early life, arising from a turned eye (strabismus), unequal refractive error (anisometropia), or form deprivation (e.g., cataract). Using high-field functional magnetic resonance imaging in a group of human adults with amblyopia, we previously demonstrated that reduced responses are observable at a thalamic level, that of the lateral geniculate nucleus (LGN)...
July 2010: Journal of Neurophysiology
No abstract text is available yet for this article.
October 11, 1947: British Medical Journal (1857-1980)
Robert F Hess, Benjamin Thompson, Glen Gole, Kathy T Mullen
Amblyopia or lazy eye is the most common cause of uniocular blindness in adults. It is caused by a disruption to normal visual development as a consequence of unmatched inputs from the two eyes in early life, arising from a turned eye (strabismus), unequal refractive error (anisometropia) or form deprivation (e.g. cataract). Animal models based on extracellular recordings in anesthetized animals suggest that the earliest site of the anomaly in the primate visual pathway is the primary visual cortex (corresponding to the striate cortex, cytoarchitectonic area 17 and area V1), which is where inputs from the two eyes are first combined in an excitatory fashion, whereas more distal and monocular processing structures such as the retina and lateral geniculate nucleus (LGN) are normal...
March 2009: European Journal of Neuroscience
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