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https://www.readbyqxmd.com/read/29224005/evidence-of-osteoclastic-activity-in-the-human-temporal-bone
#1
Takefumi Kamakura, Joseph B Nadol
Bone remodeling within the otic capsule has been reported to be inhibited especially at or near the cochlea, except under some pathological conditions such as otosclerosis, Paget's disease, or mastoiditis, when bone remodeling can occur. Microcavitations found in periosteal and endosteal layers of human temporal bone specimens without otosclerosis, Paget's disease, or inflammation as reported in the current study are consistent with osteoclastic bone resorption. Thirty-three temporal bones from 33 patients were prepared for light microscopy and classified into 4 groups: histologically proven dehiscence of the superior semicircular canal (SSCD) (n = 3, group 1), age 20 years or younger (n = 10, group 2), age 90 years or older and with otosclerosis (n = 10, group 3), and age 90 years or older without otosclerosis (n = 10, group 4)...
December 9, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29223865/prevention-of-ischemia-induced-hearing-loss-by-intravenous-administration-of-hydrogen-rich-saline-in-gerbil
#2
Hideo Ogawa, Masahiro Okada, Masachika Shudou, Kiyofumi Gyo, Naohito Hatoa
OBJECTIVE: Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. METHODS: The animals were subjected to transient cochlear ischemia by occluding the bilateral vertebral arteries for l5minutes. Five milliliters of hydrogen-rich saline was then intravenously administered immediately after the insult. Saline without hydrogen was used as a control. Effects of hydrogen were evaluated using the auditory brainstem response (ABR) and histological studies of the inner ear...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29209174/potential-mechanisms-underlying-inflammation-enhanced-aminoglycoside-induced-cochleotoxicity
#3
REVIEW
Meiyan Jiang, Farshid Taghizadeh, Peter S Steyger
Aminoglycoside antibiotics remain widely used for urgent clinical treatment of life-threatening infections, despite the well-recognized risk of permanent hearing loss, i.e., cochleotoxicity. Recent studies show that aminoglycoside-induced cochleotoxicity is exacerbated by bacteriogenic-induced inflammation. This implies that those with severe bacterial infections (that induce systemic inflammation), and are treated with bactericidal aminoglycosides are at greater risk of drug-induced hearing loss than previously recognized...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29207085/chronic-prenatal-hypoxia-impairs-cochlear-development-a-mechanism-involving-connexin26-expression-and-promoter-methylation
#4
Jingcang Lin, Huang Huang, Guorong Lv, Xiangyang Xu, Wendong Lin, Xianyan Xu, Jing Cheng, Ming Zheng
Chronic prenatal hypoxia is a damaging to fetal development and may have various consequences, including hearing loss. Connexin 26 (Cx26) is one of the major protein subunits required for gap junction formation, and has an important role in maintaining homeostasis in the cochlea and normal hearing. Cx26 mutation and expression abnormality are closely associated with inherited nonsyndromic deafness, but the association between Cx26 and prenatal hypoxia is less established. The present study aimed to examine Cx26 expression and aberrant methylation the Cx26 promoter region in the cochlea from rats exposed to chronic prenatal hypoxia...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205455/the-middle-and-inner-ears-of-the-palaeogene-golden-mole-namachloris-a-comparison-with-extant-species
#5
Matthew J Mason, Nigel C Bennett, Martin Pickford
Many living species of golden moles (Chrysochloridae) have greatly enlarged middle ear ossicles, believed to be used in the detection of ground vibrations through inertial bone conduction. Other unusual features of chrysochlorids include internally coupled middle ear cavities and the loss of the tensor tympani muscle. Our understanding of the evolutionary history of these characteristics has been limited by the paucity of fossil evidence. In this article, we describe for the first time the exquisitely preserved middle and inner ears of Namachloris arenatans from the Palaeogene of Namibia, visualised using computed tomography, as well as ossicles attributed to this species...
December 4, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29204665/-cochlear-implants-in-the-social-courts
#6
A Lottner, H Iro, A Schützenberger, U Hoppe
BACKGROUND: Since the indication for receiving a cochlear implant (CI) has widened (single-sided deafness [SSD], electric acoustic stimulation [EAS], bilateral CI, CI for long-term deafness), more and more patients come into consideration for such a treatment. Hence, disputes increasingly arise between patients and their insurance companies concerning the question of whether surgery and follow-up treatment have to be paid for by statutory health insurance. OBJECTIVE: This work provides an overview of judgments rendered by the German social courts...
December 4, 2017: HNO
https://www.readbyqxmd.com/read/29204664/-central-and-peripheral-aspects-of-noise-induced-hearing-loss
#7
REVIEW
D Basta, M Gröschel, A Ernst
Noise is an important socioeconomic problem in industrialized countries. Development of efficient treatment options for the audiological phenomena resulting from noise-induced hearing loss requires in-depth understanding of the underlying damage mechanisms causing peripheral and central nervous changes. Mechanical damage, ischemia and excitotoxicity are mainly responsible for noise-induced cell death and biophysical changes in the cochlea. Auditory synaptopathy is an additional consequence. Besides these cochlear pathologies, noise exposure leads to extensive changes within the central auditory pathway...
December 4, 2017: HNO
https://www.readbyqxmd.com/read/29197850/preoperative-simulation-unveiled-undetected-surgical-difficulties-in-a-case-of-cochlear-implantation
#8
Nozomu Matsumoto, Makoto Yamashita, Byunghyun Cho, Makoto Hashizume
We herein report a case in which extensive preparation changed a difficult-to-treat patient into an easy one. We performed a revision cochlear implantation on a patient whose first procedure had been aborted due to unidentified difficulties. During a series of thorough three-dimensional simulations, we found that the patient in question had a normal cochlea but the cochlea was placed in an unusual position and orientation. This condition is difficult to detect on standard preoperative radiographic images. Through this simulation, we were able to propose a surgical plan to avoid making the same mistakes as the first surgeon...
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29194857/computed-tomographic-characteristics-of-pneumolabyrinth-in-a-french-bulldog-with-otitis-media-and-externa
#9
Audrey Belmudes, Jérôme Couturier, Guillaume Gory, Eddy Cauvin, Guillaume Condamin, Michael Rabillard, Delphine Rault
A four-year-old female French bulldog was presented for evaluation of acute, left-sided peripheral vestibular syndrome. Computed tomographic (CT) examination of the head revealed the presence of air within the left cochlea and vestibule, consistent with pneumolabyrinth. This was concurrent with ipsilateral otitis media and externa. Pneumolabyrinth is an uncommon finding in humans and is most frequently due to head trauma and temporal bone fracture. This is the first report describing pneumolabyrinth in a dog, apparently of nontraumatic origin in this case...
December 1, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29194713/intraspecific-variation-in-the-domestic-cat-bony-labyrinth-revealed-by-different-measurement-techniques
#10
Rico Schellhorn
The knowledge of intraspecific variation is important to make assumptions on an interspecific level. To study intraspecific variation in the bony labyrinth morphology of the domestic cat, eleven specimens of Felis silvestris catus and two additional subspecies (F. s. lybica, F. s. ornata) were investigated. The sample comprises skulls of adult males and females, as well as juvenile cats. Each bony labyrinth endocast was virtually reconstructed based on µCT scans. To estimate the radius of curvature of each inner ear semicircular canal, three different approaches were tested...
December 1, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29194215/cochlear-implant-insertion-axis-into-the-basal-turn-a-critical-factor-in-electrode-array-translocation
#11
Renato Torres, Mylène Drouillard, Daniele De Seta, Jean-Loup Bensimon, Evelyne Ferrary, Olivier Sterkers, Daniele Bernardeschi, Yann Nguyen
HYPOTHESIS: An inappropriate insertion axis leads to intracochlear trauma during cochlear implantation (CI). BACKGROUND: Few studies assessed the relationship between the insertion axis and the electrode scalar location. METHODS: Preimplantation cone-beam CT (CBCT) was performed on 12 human temporal bones. In five temporal bones, an optimal insertion axis was planned, due to the impossibility to attain the ST centerline from the posterior tympanotomy, because of facial canal position...
November 29, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29194212/evaluation-of-mitoquinone-for-protecting-against-amikacin-induced-ototoxicity-in-guinea-pigs
#12
Carolyn O Dirain, Maria Raye Ann V Ng, Bailey Milne-Davies, Jerin K Joseph, Patrick J Antonelli
HYPOTHESIS: Mitoquinone (MitoQ) attenuates amikacin ototoxicity in guinea pigs. BACKGROUND: MitoQ, a mitochondria-targeted derivative of the antioxidant ubiquinone, has improved bioavailability and demonstrated safety in humans. Thus, MitoQ is a promising therapeutic approach for protecting against amikacin-induced ototoxicity. METHODS: Both oral and subcutaneous administrations of MitoQ were tested. Amikacin-treated guinea pigs (n = 12-18 per group) received water alone (control) or MitoQ 30 mg/l-supplemented drinking water; or injected subcutaneously with 3 to 5 mg/kg MitoQ or saline (control)...
November 29, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29187758/cochlear-obliteration-following-a-translabyrinthine-approach-and-its-implications-in-cochlear-implantation
#13
B Delgado-Vargas, M Medina, R Polo, A Lloris, M Vaca, C Pérez, A Cordero, I Cobeta
The most frequent sequelae following a translabyrinthine approach for vestibular schwannoma resection is complete hearing loss on the affected side. Such patients could benefit from a cochlear implant, provided that two essential requisites are met before surgery: a preserved cochlear nerve and a patent cochlea to accommodate the electrode array. The goal of our study is to determine the prevalence and extent of cochlear ossification following a translabyrinthine approach. Postoperative MRI of 41 patients were retrospectively reviewed...
November 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29182629/effects-of-peroxisome-proliferator-activated-receptors-ppar-%C3%AE-and-%C3%AE-agonists-on-cochlear-protection-from-oxidative-stress
#14
Marijana Sekulic-Jablanovic, Vesna Petkovic, Matthew B Wright, Krystsina Kucharava, Nathan Huerzeler, Soledad Levano, Yves Brand, Katharina Leitmeyer, Andrea Glutz, Alexander Bausch, Daniel Bodmer
Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabetes and dyslipidemia. These agents target the peroxisome proliferator-activated receptors, PPARγ and PPARα, which are transcription factors that influence glucose and lipid metabolism, inflammation, and organ protection. In this study, we explored the effects of pioglitazone and other PPAR agonists to prevent gentamicin-induced oxidative stress and apoptosis in mouse organ of Corti (OC) explants...
2017: PloS One
https://www.readbyqxmd.com/read/29181442/weak-middle-ear-muscle-reflex-in-humans-with-noise-induced-tinnitus-and-normal-hearing-may-reflect-cochlear-synaptopathy
#15
Magdalena Wojtczak, Jordan A Beim, Andrew J Oxenham
Chronic tinnitus is a prevalent hearing disorder, and yet no successful treatments or objective diagnostic tests are currently available. The aim of this study was to investigate the relationship between the presence of tinnitus and the strength of the middle-ear-muscle reflex (MEMR) in humans with normal and near-normal hearing. Clicks were used as test stimuli to obtain a wideband measure of the effect of reflex activation on ear-canal sound pressure. The reflex was elicited using a contralateral broadband noise...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29174619/an-elemental-approach-to-modelling-the-mechanics-of-the-cochlea
#16
REVIEW
Stephen J Elliott, Guangjian Ni
The motion along the basilar membrane in the cochlea is due to the interaction between the micromechanical behaviour of the organ of Corti and the fluid movement in the scalae. By dividing the length of the cochlea into a finite number of elements and assuming a given radial distribution of the basilar membrane motion for each element, a set of equations can be separately derived for the micromechanics and for the fluid coupling. These equations can then be combined, using matrix methods, to give the fully coupled response...
November 1, 2017: Hearing Research
https://www.readbyqxmd.com/read/29169906/limits-on-normal-cochlear-third-windows-provided-by-previous-investigations-of-additional-sound-paths-into-and-out-of-the-cat-inner-ear
#17
John J Rosowski, Peter Bowers, Hideko H Nakajima
While most models of cochlear function assume the presence of only two windows into the mammalian cochlea (the oval and round windows), a position that is generally supported by several lines of data, there is evidence for additional sound paths into and out of the inner ear in normal mammals. In this report we review the existing evidence for and against the 'two-window' hypothesis. We then determine how existing data and inner-ear anatomy restrict transmission of sound through these additional sound pathways in cat by utilizing a well-tested model of the cat inner ear, together with anatomical descriptions of the cat cochlear and vestibular aqueducts (potential additional windows to the cochlea)...
November 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/29163050/mechanisms-of-cisplatin-induced-ototoxicity-and-otoprotection
#18
REVIEW
Sandeep Sheth, Debashree Mukherjea, Leonard P Rybak, Vickram Ramkumar
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect. It has generally been accepted that hearing loss is produced by excessive generation of reactive oxygen species (ROS) in cell of the cochlea, which led to the development of various antioxidants as otoprotective agents. Later studies show that ROS could stimulate cochlear inflammation, suggesting the use of anti-inflammatory agents for treatment of hearing loss...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29162831/cisplatin-is-retained-in-the-cochlea-indefinitely-following-chemotherapy
#19
Andrew M Breglio, Aaron E Rusheen, Eric D Shide, Katharine A Fernandez, Katie K Spielbauer, Katherine M McLachlin, Matthew D Hall, Lauren Amable, Lisa L Cunningham
Cisplatin chemotherapy causes permanent hearing loss in 40-80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry (ICP-MS) to examine cisplatin pharmacokinetics in the cochleae of mice and humans. In most organs cisplatin is detected within one hour after injection, and is eliminated over the following days to weeks. In contrast, the cochlea retains cisplatin for months to years after treatment in both mice and humans...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29160929/anatomical-variations-of-the-human-cochlea-determined-from-micro-ct-and-high-resolution-ct-imaging-and-reconstruction
#20
Jie Tang, Xianglong Tang, Zhenhua Li, YiKang Liu, SongHua Tan, Heng Li, RongDan Ke, Zhi Wang, Li Gong, AnZhou Tang
Understanding the anatomical variations in the human cochlea are important for cochlear implants. This study examined these variations using a reconstructed fusion model of the skull and temporal bone. The 3D digital model of the temporal bone was reconstructed from multiple axial micro-CT scans of temporal bone and high resolution CT (HRCT) of the skull from 15 cadavers. A skull model was reconstructed and merged with the reconstructed temporal bone. The 3D relationship between the cochlea and the skull's mid-sagittal plane was analyzed...
November 21, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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