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https://www.readbyqxmd.com/read/29676295/effects-of-parenteral-papaverine-and-piracetam-administration-on-cochlea-following-acoustic-trauma
#1
Nurcan Yurtsever Kum, Yavuz F Yilmaz, Seren G Gurgen, Rauf O Kum, Muge Ozcan, Adnan Unal
Introduction: Noise exposure, the main cause of hearing loss in countries with lot of industries, may result both in temporary or permanent hearing loss. The goal of this study was to investigate the effects of parenteral papaverine and piracetam administration following an acoustic trauma on hearing function with histopathologic correlation. Materials and Methods: Eighteen Wistar albino rats exposed to noise for 8 h in a free environment were included. We divided the study population into three groups, and performed daily intraperitoneal injections of papaverine, piracetam, and saline, respectively, throughout the study...
March 2018: Noise & Health
https://www.readbyqxmd.com/read/29675997/hearing-vulnerability-after-noise-exposure-in-a-mouse-model-of-reactive-oxygen-species-overproduction
#2
Shigefumi Morioka, Hirofumi Sakaguchi, Taro Yamaguchi, Yuzuru Ninoyu, Hiroaki Mohri, Takashi Nakamura, Yasuo Hisa, Kiyokazu Ogita, Naoaki Saito, Takehiko Ueyama
Previous studies have convincingly argued that reactive oxygen species (ROS) contribute to the development of several major types of sensorineural hearing loss, such as noise-induced hearing loss (NIHL), drug-induced hearing loss, and age-related hearing loss. However, the underlying molecular mechanisms induced by ROS in these pathologies remain unclear. To resolve this issue, we established an in vivo model of ROS overproduction by generating a transgenic (TG) mouse line expressing the human NADPH oxidase 4 (NOX4, NOX4-TG mice), which is a constitutively active ROS-producing enzyme that does not require stimulation or an activator...
April 20, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29674954/bioinformatic-integration-of-molecular-networks-and-major-pathways-involved-in-mice-cochlear-and-vestibular-supporting-cells
#3
Teresa Requena, Alvaro Gallego-Martinez, Jose A Lopez-Escamez
Background : Cochlear and vestibular epithelial non-hair cells (ENHCs) are the supporting elements of the cellular architecture in the organ of Corti and the vestibular neuroepithelium in the inner ear. Intercellular and cell-extracellular matrix interactions are essential to prevent an abnormal ion redistribution leading to hearing and vestibular loss. The aim of this study is to define the main pathways and molecular networks in the mouse ENHCs. Methods : We retrieved microarray and RNA-seq datasets from mouse epithelial sensory and non-sensory cells from gEAR portal (http://umgear...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29673779/protective-effect-of-gallic-acid-against-cisplatin-induced-ototoxicity-in-rats
#4
Korhan Kilic, Muhammed Sedat Sakat, Fazile Nur Ekinci Akdemir, Serkan Yildirim, Yavuz Selim Saglam, Seda Askin
INTRODUCTION: Cisplatin is an antineoplastic agent widely used in the treatment of a variety of cancers. Ototoxicity is one of the main side-effects restricting the use of cisplatin. OBJECTIVE: The purpose of this study was to investigate the protective efficacy of gallic acid, in biochemical, functional and histopathological terms, against ototoxicity induced by cisplatin. METHODS: Twenty-eight female Sprague Dawley rats were included. Rats were randomly assigned into four groups of seven animals each...
April 7, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29664150/conductive-hearing-loss-in-four-dogs-associated-with-the-use-of-ointment-based-otic-medications
#5
Lynette K Cole, Päivi J Rajala-Schultz, Gwendolen Lorch
BACKGROUND: Hearing loss (HL) is classified as conductive when sound transmission is compromised in the ear canal or middle ear, or sensorineural when there is an abnormality of the receptor cells of the cochlea or auditory pathway. Hearing in dogs is evaluated using the brainstem auditory evoked response (BAER) test. HYPOTHESIS/OBJECTIVES: Our objective was to characterize BAER findings pre- and post-ear flushing in four dogs with acute HL following application of an ointment-based otic medication containing betamethasone, clotrimazole and gentamicin in a mineral oil-based system containing a plasticized hydrocarbon gel...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29662891/transient-abnormalities-in-masking-tuning-curve-in-early-progressive-hearing-loss-mouse-model
#6
Marion Souchal, Ludimila Labanca, Sirley Alves da Silva Carvalho, Luciana Macedo de Resende, Christelle Blavignac, Paul Avan, Fabrice Giraudet
Damage to cochlear outer hair cells (OHCs) usually affects frequency selectivity in proportion to hearing threshold increase. However, the current clinical heuristics that attributes poor hearing performance despite near-normal auditory sensitivity to auditory neuropathy or "hidden" synaptopathy overlooks possible underlying OHC impairment. Here, we document the part played by OHCs in influencing suprathreshold auditory performance in the presence of noise in a mouse model of progressive hair cell degeneration, the CD1 strain, at postnatal day 18-30 stages when high-frequency auditory thresholds remained near-normal...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29661614/a-fluorescence-based-imaging-approach-to-pharmacokinetic-analysis-of-intracochlear-drug-delivery
#7
Andrew M Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jeffrey T Borenstein
Advances in microelectromechanical systems (MEMS) technologies are enhancing the development of intracochlear delivery devices for the treatment of hearing loss with emerging pharmacological therapies. Direct intracochlear delivery addresses the limitations of systemic and intratympanic delivery. However, optimization of delivery parameters for these devices requires pharmacokinetic assessment of the spatiotemporal drug distribution inside the cochlea. Robust methods of measuring drug concentration in the perilymph have been developed, but lack spatial resolution along the tonotopic axis or require complex physiological measurements...
April 5, 2018: Hearing Research
https://www.readbyqxmd.com/read/29661613/functions-of-cabp1-and-cabp2-in-the-peripheral-auditory-system
#8
Tian Yang, Ning Hu, Tina Pangršič, Steven Green, Marlan Hansen, Amy Lee
CaBPs are a family of Ca2+ binding proteins related to calmodulin. Two CaBP family members, CaBP1 and CaBP2, are highly expressed in the cochlea. Here, we investigated the significance of CaBP1 and CaBP2 for hearing in mice lacking expression of these proteins (CaBP1 KO and CaBP2 KO) using auditory brain responses (ABRs) and distortion product otoacoustic emissions (DPOAEs). In CaBP1 KO mice, ABR wave I was larger in amplitude, and shorter in latency and faster in decay, suggestive of enhanced synchrony of auditory nerve fibers...
April 9, 2018: Hearing Research
https://www.readbyqxmd.com/read/29658405/real-time-intracochlear-imaging-of-automated-cochlear-implant-insertions-in-whole-decalcified-cadaver-cochleas-using-ultrasound
#9
Thomas G Landry, Guy Earle, Jeremy A Brown, Manohar L Bance
OBJECTIVES: This study aimed to determine the feasibility of combining high-frequency ultrasound imaging, automated insertion, and force sensing to yield more information about cochlear implant insertion dynamics. METHODS: An apparatus was developed combining these aspects along with software to control implant and imaging probe positions. Decalcified unfixed human cochleas were implanted at various speeds, insertion sites, and implant models while imaging near the implant tip throughout insertion and recording force data from the cochlea mounting stage...
April 16, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29649050/temporal-bone-histopathology-in-cockayne-syndrome
#10
Ophir Handzel, Joseph B Nadol
: Cockayne syndrome (CS) is a rare autosomal recessive syndrome resulting in defective DNA repair. Its features include cachectic dwarfism, hearing loss, skin hypersensitivity to sunlight, premature aging, and dementia. Presented is a right temporal bone of a patient who died at the age of 29 years. The clinical course was compatible with type 1 CS, the classical form. Homozygous missense variant in the ERCC6 gene (Excision Repair Cross-Complementation group 6) was found, compatible with CS complementation group B...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29643760/a-comparison-of-low-complexity-real-time-feature-extraction-for-neuromorphic-speech-recognition
#11
Jyotibdha Acharya, Aakash Patil, Xiaoya Li, Yi Chen, Shih-Chii Liu, Arindam Basu
This paper presents a real-time, low-complexity neuromorphic speech recognition system using a spiking silicon cochlea, a feature extraction module and a population encoding method based Neural Engineering Framework (NEF)/Extreme Learning Machine (ELM) classifier IC. Several feature extraction methods with varying memory and computational complexity are presented along with their corresponding classification accuracies. On the N-TIDIGITS18 dataset, we show that a fixed bin size based feature extraction method that votes across both time and spike count features can achieve an accuracy of 95% in software similar to previously report methods that use fixed number of bins per sample while using ~3× less energy and ~25× less memory for feature extraction (~1...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29643172/the-syndromic-deafness-mutation-g12r-impairs-fast-and-slow-gating-in-cx26-hemichannels
#12
Isaac E García, Felipe Villanelo, Gustavo F Contreras, Amaury Pupo, Bernardo I Pinto, Jorge E Contreras, Tomás Pérez-Acle, Osvaldo Alvarez, Ramon Latorre, Agustín D Martínez, Carlos González
Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical properties of the syndromic mutant Cx26G12R (G12R). Unlike wild-type Cx26, G12R macroscopic hemichannel currents do not saturate upon depolarization, and deactivation is faster during hyperpolarization, suggesting that these channels have impaired fast and slow gating...
April 11, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29622283/a-comparison-of-cochlear-distribution-and-glucocorticoid-receptor-activation-in-local-and-systemic-dexamethasone-drug-delivery-regimes
#13
Nathan J Creber, Hayden T Eastwood, Amy J Hampson, Justin Tan, Stephen J O'Leary
Local and systemically delivered glucocorticoids are commonly administered to protect the cochlea against damage associated with a variety of insults. There is reason to believe that dexamethasone administered by these routes may arrive at cochlear target sites via different pathways. Clinically, there is a lack of clarity as to which route is more effective in any specific circumstance. This study explores dexamethasone distribution within the guinea pig cochlea following local and systemic delivery methods...
March 20, 2018: Hearing Research
https://www.readbyqxmd.com/read/29620546/comparison-of-cochlear-duct-length-between-the-saudi-and-non-saudi-populations
#14
Alaa Alanazi, Farid Alzhrani
BACKGROUND: There are no data on cochlear duct lengths (CDL) among Middle East populations. OBJECTIVES: The main aims of this study were to estimate the average CDL in the Saudi population and to compare it with the reported CDL in other regions/ethnic groups outside the Middle East. DESIGN: Retrospective study. SETTING: Tertiary otolaryngology head and neck surgery center. SUBJECTS AND METHODS: Temporal bone CT scans were reviewed to determine CDL...
March 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29620237/a-novel-missense-mutation-in-the-actg1-gene-in-a-family-with-congenital-autosomal-dominant-deafness-a-case-report
#15
Cha Gon Lee, Jahyeon Jang, Hyun-Seok Jin
The ACTG1 gene encodes the cytoskeletal protein γ-actin, which functions in non‑muscle cells and is abundant in the auditory hair cells of the cochlea. Autosomal dominant missense mutations in ACTG1 are associated with DFNA20/26, a disorder that is typically characterized by post‑lingual progressive hearing loss. To date, 17 missense mutations in ACTG1 have been reported in 20 families with DFNA20/26. The present study described a small family with autosomal dominant nonsyndromic hearing loss. A novel heterozygous missense mutation, c...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29619376/susceptibility-of-diabetic-mice-to-noise-trauma
#16
Wook Kyoung Han, Eung Hyub Kim, Sun-Ae Shin, Dong-Sik Shin, Bong Jik Kim, Ah-Ra Lyu, Yong-Ho Park
Diabetes can lead to many end-organ complications. However, the association between diabetes and hearing loss is not well understood. Here, we investigated the effect of noise exposure on diabetic mice compared with wild-type mice. Hearing threshold shifts, histopathologic changes in the cochlea, and inflammatory responses were evaluated over time. After noise exposure, more severe hearing threshold shifts, auditory hair cell loss, and synaptopathies were notable in diabetic mice compared with wild-type mice...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29619108/the-effects-of-experimental-intratympanic-steroid-administration-on-organ-of-corti-type-1-spiral-ganglion
#17
Turgay Topcuoglu, Murat Kocyıgıt, Erdogan Bulut, Safiye G Ortekın, Mehmet Kanter, Recep Yagız
Introduction  It is unclear how effective is the intratympanic (IT) steroid treatment on organ of Corti type 1 spiral ganglion, its optimal dosage and frequency of administration. The effect of dexamethasone on cochlear functions in individuals with a normal hearing ability is also unknown. Objective  The aim of this study was to evaluate, at the electrophysiological and ultrastructural levels, the effect of IT dexamethasone administration in guinea pigs with normal hearing on organ of Corti type 1 spiral ganglion...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29610960/imaging-evaluation-of-electrode-placement-and-effect-on-electrode-discrimination-on-different-cochlear-implant-electrode-arrays
#18
Ángel Ramos de Miguel, Andrea A Argudo, Silvia A Borkoski Barreiro, Juan Carlos Falcón González, Angel Ramos Macías
The aim of the present study is to evaluate the effect of electrode discrimination based on electrode to modiolus distance in different cochlear implant models, using image information to estimate the outcomes after an implantation on electrode discrimination METHODS: A descriptive prospective randomized study performed during 16 months. A psychoacoustic platform was used to evaluate patients' electrode discrimination capabilities of patients. For the acquisition of the images, a cone beam computed tomography was used to assess postcochlear implantation of electrodes' position...
April 2, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29608150/trans-tympanic-drug-delivery-for-the-treatment-of-ototoxicity
#19
Kelly Sheehan, Sandeep Sheth, Debashree Mukherjea, Leonard P Rybak, Vickram Ramkumar
The systemic administration of protective agents to treat drug-induced ototoxicity is limited by the possibility that these protective agents could interfere with the chemotherapeutic efficacy of the primary drugs. This is especially true for the drug cisplatin, whose anticancer actions are attenuated by antioxidants which provide adequate protection against hearing loss. Other current or potential otoprotective agents could pose a similar problem, if administered systemically. The application of various biologicals or protective agents directly to the cochlea would allow for high levels of these agents locally with limited systemic side effects...
March 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29607748/auditory-brainstem-implant-in-postmeningitis-totally-ossified-cochleae
#20
Andréa Felice Dos Santos Malerbi, Maria Valéria Schmidt Goffi-Gomes, Robinson Koji Tsuji, Marcos Queiroz Teles Gomes, Rubens de Brito Neto, Ricardo Ferreira Bento
INTRODUCTION: An auditory brainstem implant (ABI) is an option for auditory rehabilitation in patients with totally ossified cochleae who cannot receive a conventional cochlear implant. OBJECTIVE: To evaluate the outcomes in audiometry and speech perception tests after the implantation of an ABI via the extended retrolabyrinthine approach in patients with postmeningitis hearing loss. MATERIALS AND METHODS: Ten patients, including children and adults, with postmeningitis hearing loss and bilateral totally ossified cochleae received an ABI in a tertiary center from 2009 to 2015...
April 1, 2018: Acta Oto-laryngologica
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