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https://www.readbyqxmd.com/read/28643534/transplantation-of-mouse-induced-pluripotent-stem-cells-into-the-cochlea-for-the-treatment-of-sensorineural-hearing-loss
#1
Jing Chen, Lina Guan, Hengtao Zhu, Shan Xiong, Liang Zeng, Hongqun Jiang
CONCLUSION: Mouse-induced pluripotent stem cells (iPSCs) could differentiate into hair cell-like cells and spiral ganglion-like cells after transplantation into mouse cochleae, but it cannot improve the auditory brain response (ABR) thresholds in short term. OBJECTIVE: To evaluate the potential of iPSCs for use as a source of transplants for the treatment of sensorineural hearing loss (SNHL). METHODS: Establishing SNHL mice model, then injecting the iPSCs or equal volume DMEM basic medium into the cochleae, respectively...
June 23, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28636736/the-protective-effect-of-intratympanic-dexamethasone-on-streptomycin-ototoxicity-in-rats
#2
Aylin Gül, Engin Şengül, Beyhan Yılmaz, Fazıl Emre Özkurt, Mehmet Akdağ, Ayşenur Keleş, İsmail Topçu
The purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28636731/correlation-among-external-auditory-canal-anomaly-temporal-bone-malformation-and-hearing-levels-in-patients-with-microtia
#3
Kun Chen, Liu Liu, Runjie Shi, Peihua Wang, Dong Chen, Hua Xiao
We conducted a retrospective study to evaluate the relationship between external auditory canal (EAC) anomaly, temporal bone abnormality, and hearing levels using objective scoring systems in Chinese patients with microtia. The study population consisted of 106 ears of 94 Chinese patients (67 male and 27 female) aged 5 to 45 years (mean: 12.6) with microtia. The EAC abnormalities were classified into 4 types according to Schuknecht's criteria: type A, type B, type C, and type D. Developmental anomalies of the temporal bone were evaluated by Jahrsdoerfer computed tomography (CT) scoring system using high-resolution CT scans of the temporal bone...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28636628/effects-of-spirulina-on-the-functions-and-redox-status-of-auditory-system-in-senescence-accelerated-prone-8-mice
#4
Yin-Ching Chan, Juen-Haur Hwang
To our knowledge, the effects of Spirulina platensis water extract (SP) on hearing function have not yet been reported. This study investigated the effects of SP on the function and redox status of the auditory system. Auditory brainstem responses and redox status were compared between two groups of 3-month-old senescence-accelerated prone-8 (SAMP8) mice: the control group was fed a normal diet, and the experimental group was fed a normal diet with oral supplementation of SP for 6 weeks. Compared with the control group, the experimental group had significantly lower hearing thresholds according to auditory brainstem responses measured using click sounds and 8-kHz tone burst sound stimulation at the end of this study...
2017: PloS One
https://www.readbyqxmd.com/read/28633959/characterization-of-the-superior-olivary-complex-of-canis-lupus-domesticus
#5
Tatiana Fech, Lilian Calderón-Garcidueñas, Randy J Kulesza
The superior olivary complex (SOC) is a collection of brainstem auditory nuclei which play essential roles in the localization of sound sources, temporal coding of vocalizations and descending modulation of the cochlea. Notwithstanding, the SOC nuclei vary considerably between species in accordance with the auditory needs of the animal. The canine SOC was subjected to anatomical and physiological examination nearly 50 years ago and was then virtually forgotten. Herein, we aimed to characterize the nuclei of the canine SOC using quantitative morphometrics, estimation of neuronal number, histochemistry for perineuronal nets and immunofluorescence for the calcium binding proteins calbindin and calretinin...
June 15, 2017: Hearing Research
https://www.readbyqxmd.com/read/28632772/characterization-of-slow-cycling-cells-in-the-mouse-cochlear-lateral-wall
#6
Yang Li, Kotaro Watanabe, Masato Fujioka, Kaoru Ogawa
Cochlear spiral ligament fibrocytes (SLFs) play essential roles in the physiology of hearing including ion recycling and the generation of endocochlear potential. In adult animals, SLFs can repopulate after damages, yet little is known about the characteristics of proliferating cells that support SLFs' self-renewal. Here we report in detail about the characteristics of cycling cells in the spiral ligament (SL). Fifteen P6 mice and six noise-exposed P28 mice were injected with 5-bromo-2'-deoxyuridine (BrdU) for 7 days and we chased BrdU retaining cells for as long as 60 days...
2017: PloS One
https://www.readbyqxmd.com/read/28631670/-topographic-anatomy-of-the-hook-region-and-its-significance-for-the-choice-of-the-surgical-technique-for-the-cochlear-implantation
#7
Yu K Yanov, V E Kuzovkov, A S Lilenko, I V Kostevich, S B Sugarova, A Sh Amonov
The mode of the introduction of the active electrode of a cochlear implant into the cochlea remains a key issue as far as cochlear implantation is concerned. Especially much attention has recently been given to the relationship between the anatomical features of the basal region of the cochlea (the so-called 'fish hook') and the possibility to approach it. We have undertaken the attempt to optimize the approach to the tympanic canal (scala tympanica) of the cochlea with a view to reducing to a minimum the risk of an injury to the cochlear structures in the course of cochlear implantation...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631523/the-association-among-prematurity-cochlear-hyperintensity-and-hearing-loss
#8
Michael A Wien, Matthew T Whitehead
Background Prematurity is a major risk factor for neonatal hearing loss. Recent advancements in magnetic resonance imaging (MRI) have made it possible to evaluate structural details of the membranous labyrinths in premature infants that have heretofore been inaccessible. Objective We compared the prevalence of abnormal cochlear signal intensity in premature and term neonates and evaluated for a potential link with hearing loss. Materials and methods We retrospectively reviewed 148 consecutive MR exams performed in premature (< 37 weeks' gestation) and term neonates performed over a 30-month period...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28631161/the-role-of-eabr-with-intracochlear-test-electrode-in-decision-making-between-cochlear-and-brainstem-implants-preliminary-results
#9
Betul Cicek Cinar, Mehmet Yarali, Gamze Atay, Munir Demir Bajin, Gonca Sennaroglu, Levent Sennaroglu
The objective of the study was to discuss the findings of intraoperative electrically evoked auditory brainstem response (eABR) test results with a recently designed intracochlear test electrode (ITE) in terms of their relation to decisions of cochlear or auditory brainstem implantation. This clinical study was conducted in Hacettepe University, Department of Otolaryngology, Head and Neck Surgery and Department of Audiology. Subjects were selected from inner ear malformation (IEM) database. Eleven subjects with profound sensorineural hearing loss were included in the current study with age range from 1 year 3 months to 4 years 3 months for children with prelingual hearing loss...
June 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28630884/evaluation-of-a-high-resolution-patient-specific-model-of-the-electrically-stimulated-cochlea
#10
Ahmet Cakir, Robert T Dwyer, Jack H Noble
Cochlear implants (CIs) are surgically implanted medical devices used to treat individuals with severe-to-profound sensorineural hearing loss. Although these devices have been remarkably successful at restoring audibility, many patients experience poor outcomes. Our group has developed the first image-guided CI programming technique where the electrode positions are found in CT images and used to estimate neural activation patterns, which is unique information that audiologists can use to define patient-specific processor settings...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28628917/anatomical-characteristics-of-facial-nerve-and-cochlea-interaction
#11
Nadine Schart-Morén, Sune Larsson, Helge Rask-Andersen, Hao Li
OBJECTIVE: The aim was to study the relationship between the labyrinthine portion (LP) of the facial canal and the cochlea in human inner ear molds and temporal bones using micro-CT and 3D rendering. A reduced cochlea-facial distance may spread electric currents from the cochlear implant to the LP and cause facial nerve stimulation. Influencing factors may be the topographic anatomy and otic capsule properties. METHODS: An archival collection of human temporal bones underwent micro-CT and 3D reconstruction...
June 20, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28628154/-morphological-changes-on-cochlear-hair-cells-of-rats-in-simulated-weightlessness-and-inboard-noise
#12
(no author information available yet)
OBJECTIVE: To observe the morphological changes on cochlear hair cells of rats in simulated weightlessness and inboard noise and to investigate the different changes in three turns of hair cells. METHODS: Thirty-two healthy SD rats, all males, were randomly divided into four groups: control group, weightlessness group, noise group and weightlessness+noise groups (n=8). Then rats were exposed to -30° head down tilt as simulated weightlessness and inboard noise including steady-state noise which was (72±2) dB SPL and impulse noise up to 160 dB SPL in spaceship environment...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28627704/matrix-metalloproteinase-2-and-9-contribute-to-functional-integrity-and-noise%C3%A2-induced-damage-to-the-blood-labyrinth-barrier
#13
Jun Wu, Weiju Han, Xingrui Chen, Weiwei Guo, Ke Liu, Ruoya Wang, Jishuai Zhang, Na Sai
The cochlear blood-labyrinth barrier (BLB), located in the stria vascularis, is critical for the homeostasis of cochlear solutes and ion transport. Significant disruption to the BLB occurs early during noise‑induced hearing loss. Matrix metalloproteinase (MMP)‑2 and ‑9 are important molecules known to be capable of degrading tight junction (TJ) proteins. The TJ proteins are important components of the extracellular matrix (ECM), required to maintain BLB integrity and permeability. Previous studies have demonstrated that MMP‑2 and ‑9, rich in healthy cochlea, serve an essential role in regulating the cochlear response to acoustic trauma...
June 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627458/sirna-loaded-biodegradable-nanocarriers-for-therapeutic-mapk1-silencing-against-cisplatin-induced-ototoxicity
#14
Ibrahima Youm, Matthew B West, Wei Li, Xiaoping Du, Don Ewert, Richard D Kopke
Ototoxicity represents a major adverse side-effect of cis-diamminedichloroplatinum-II (cisplatin, CDDP). The mitogen-activated protein kinase (MAPK) pathway is thought to play a central role in potentiating the apoptotic effect of CDDP within the cochlea. We hypothesized that prophylactic inhibition of MAPK signaling, using small interfering RNA (siRNA), might confer a protective effect against CDDP-induced apoptosis within the auditory sensory epithelia. To enhance the therapeutic utility of this approach, we synthesized biocompatible siMAPK1-loaded nanoparticles (NPs) and performed physicochemical characterizations for size, morphology, and drug loading and release kinetics, using dynamic light scattering, electron microscopy and spectrophotometric analyses, respectively...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28625810/evaluating-the-ototoxicity-of-a-anti-mrsa-peptide-kr-12-a2
#15
Chung Man Sung, Hong Chan Kim, Yong Beom Cho, Song Yub Shin, Chul Ho Jang
INTRODUCTION: Methicillin-Resistant Staphylococcus aureus (MRSA) is an emerging problem for the treatment of chronic suppurative otitis media, and also for pediatric tympanostomy tube otorrhea. To date, there are no effective topical antibiotic drugs to treat MRSA otorrhea. OBJECTIVE: In this study, we evaluated the ototoxicity of topical KR-12-a2 solution on the cochlea when it applied topically in the middle ear of guinea pigs. METHODS: The antimicrobial activity of KR-12-a2 against MRSA strains was examined by using the inhibition zone test...
May 31, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28620284/electrophysiological-measurements-of-peripheral-vestibular-function-a-review-of-electrovestibulography
#16
REVIEW
Daniel J Brown, Christopher J Pastras, Ian S Curthoys
Electrocochleography (EcochG), incorporating the Cochlear Microphonic (CM), the Summating Potential (SP), and the cochlear Compound Action Potential (CAP), has been used to study cochlear function in humans and experimental animals since the 1930s, providing a simple objective tool to assess both hair cell (HC) and nerve sensitivity. The vestibular equivalent of ECochG, termed here Electrovestibulography (EVestG), incorporates responses of the vestibular HCs and nerve. Few research groups have utilized EVestG to study vestibular function...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28619840/does-3t-fetal-mri-improve-image-resolution-of-normal-brain-structures-between-20-and-24-weeks-gestational-age
#17
G Priego, N J Barrowman, J Hurteau-Miller, E Miller
BACKGROUND AND PURPOSE: Stronger magnetic fields have the potential to improve fetal image resolution. Our objective was to detect whether there was better anatomic resolution of brain structures in fetuses imaged with a 3T magnet compared with a 1.5T magnet. MATERIALS AND METHODS: Multiple cerebral and facial anatomic structures were retrospectively assessed in 28 fetal MR imaging scans with normal findings (12 at 3T and 16 at 1.5T) with a 0 -3 grading score. Fetuses were assessed during the second trimesters (gestational age, 20 -24 weeks)...
June 15, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28616773/intracochlear-schwannoma-tumor-removal-via-subtotal-cochleoectomy-and-partial-cochlear-reconstruction-with-preservation-of%C3%A2-semicircular-canal-function
#18
S K Plontke, S Kösling, N Pazaitis, T Rahne
We report about a patient, who in 2005, as a 37-year-old, experienced a sudden, mild to moderate, mid-frequency sensorineural hearing loss in the right ear, along with tinnitus and mild dizziness. MRI of the temporal bone revealed a very small (1 mm) enhancing lesion in the second turn of the right cochlea after injection of contrast medium. Hearing gradually deteriorated, with complete hearing loss in 2015. At this time, an MRI scan showed a lesion completely filling the cochlea.The tumor was removed through a subtotal cochleoectomy...
June 14, 2017: HNO
https://www.readbyqxmd.com/read/28610019/four-new-species-of-i-callibaetis-i-eaton-ephemeroptera-baetidae-nymphal-description-of-i-callibaetis-i-i-abaetetuba-i-fasciatus-pictet-and-keys-for-south-american-species-of-i-callibaetis-i
#19
Paulo Vilela Cruz, Frederico Falcão Salles, Neusa Hamada
The first phylogenetic study of Callibaetis Eaton indicated an unrevealed diversity in this genus, including four new species named as Callibaetis sp. A, B, C and D, and the undescribed nymph of Callibaetis (Abaetetuba) fasciatus (Pictet). Given that neither the nymph of C. (Ab.) fasciatus nor the four new species received a proper description, the objective of this study is to describe them. The nymph of C. (Ab.) fasciatus differs from the others species in the subgenus by the presence of one row of setae on basal part of inner-dorsal row of maxilla and metanotum without spines; Callibaetis sp...
April 5, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608735/hearing-preservation-does-electrode-choice-matter
#20
Leila J Mady, Daniel C Sukato, Jenifer Fruit, Catherine Palmer, Yael Raz, Barry E Hirsch, Andrew A McCall
Objective Evaluate if electrode design affects hearing preservation (HP) following cochlear implantation (CI) with full-length electrodes. Study Design Case series with chart review. Setting Tertiary referral academic center. Subjects and Methods Forty-five adults with low-frequency hearing (≤85 dB at 250 and 500 Hz) who underwent unilateral CI with full-length electrode arrays made by 1 manufacturer were included. HP was calculated with (1) mean low-frequency pure-tone average (LFPTA) at 250 and 500 Hz (MEAN method), (2) a percentile method across the audiometric frequency spectrum generating an S-value (HEARRING method), and (3) functional if hearing remained ≤85 dB at 250 and 500 Hz...
June 1, 2017: Otolaryngology—Head and Neck Surgery
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