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https://www.readbyqxmd.com/read/27913265/hearing-preservation-during-anterior-petrosectomy-the-cochlear-safety-line
#1
Xiaoming Guo, Halima Tabani, Dylan Griswold, Ali Tayebi Meybodi, Jose Juan Gonzalez Sanchez, Michael T Lawton, Arnau Benet
BACKGROUND: Identification and protection of the cochlea during anterior petrosectomy is key to prevent hearing loss. Currently, there is no optimal method to infer the position of the cochlea in relation to the Kawase quadrangle, therefore damage to the cochlea during anterior petrosectomy remains a substantial risk. OBJECTIVES: To identify and define landmarks available during anterior petrosectomy to locate the cochlea and prevent its damage. METHODS: Kawase approach was simulated in eleven specimens...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27910089/bilateral-endolymphatic-hydrops-in-a-patient-with-migraine-variant-without-vertigo-a-case-report
#2
Isabelle Y Liu, Akira Ishiyama, Ali R Sepahdari, Kevin Johnson, Gail Ishiyama
OBJECTIVE: To use modern high-resolution inner ear imaging modalities to evaluate for endolymphatic hydrops (EH) in a patient with migraine-associated fluctuating hearing loss without vertigo spells or dizziness. BACKGROUND: EH has been well described in patients with Meniere's disease on both human temporal bone studies and modern high-resolution imaging; however, there is no study to date, to our knowledge, that examines the presence of EH in a patient with migraine and bilateral hearing loss...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27909837/simultaneous-intracochlear-pressure-measurements-from-two-cochlear-locations-propagation-of-distortion-products-in-gerbil
#3
Wei Dong
Sound energy propagates in the cochlea through a forward-traveling or slow wave supported by the cochlear partition and fluid inertia. Additionally, cochlear models support traveling wave propagation in the reverse direction as the expected mechanism for conveying otoacoustic emissions out of the cochlea. Recently, however, this hypothesis has been questioned, casting doubt on the process by which otoacoustic emissions travel back out through the cochlea. The proposed alternative reverse travel path for emissions is directly through the fluids of the cochlea as a compression pressure in the form of a fast wave...
December 1, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27908067/lateralization-of-interaural-timing-differences-with-multi-electrode-stimulation-in-bilateral-cochlear-implant-users
#4
Alan Kan, Heath G Jones, Ruth Y Litovsky
Bilateral cochlear implant (BiCI) users have shown variability in interaural time difference (ITD) sensitivity at different places along the cochlea. This paper investigates perception of multi-electrode binaural stimulation to determine if auditory object formation (AOF) and lateralization are affected by variability in ITD sensitivity when a complex sound is encoded with multi-channel processing. AOF and ITD lateralization were compared between single- and multi-electrode configurations. Most (7/8) BiCI users perceived a single auditory object with multi-electrode stimulation, and the range of lateralization was comparable to single-electrode stimulation, suggesting that variability in single-electrode ITD sensitivity does not compromise AOF with multi-electrode stimulation...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27908030/influences-of-noise-interruption-and-information-bearing-acoustic-changes-on-understanding-simulated-electric-acoustic-speech
#5
Christian Stilp, Gail Donaldson, Soohee Oh, Ying-Yee Kong
In simulations of electrical-acoustic stimulation (EAS), vocoded speech intelligibility is aided by preservation of low-frequency acoustic cues. However, the speech signal is often interrupted in everyday listening conditions, and effects of interruption on hybrid speech intelligibility are poorly understood. Additionally, listeners rely on information-bearing acoustic changes to understand full-spectrum speech (as measured by cochlea-scaled entropy [CSE]) and vocoded speech (CSECI), but how listeners utilize these informational changes to understand EAS speech is unclear...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27903185/acute-clinical-adverse-radiation-effects-after-gamma-knife-surgery-for-vestibular-schwannomas
#6
Constantin Tuleasca, Mercy George, Mohamed Faouzi, Luis Schiappacasse, Henri-Arthur Leroy, Michele Zeverino, Roy Thomas Daniel, Raphael Maire, Marc Levivier
OBJECTIVE Vestibular schwannomas (VSs) represent a common indication of Gamma Knife surgery (GKS). While most studies focus on the long-term morbidity and adverse radiation effects (AREs), none describe the acute clinical AREs that might appear on a short-term basis. These types of events are investigated, and their incidence, type, and outcomes are reported in the present paper. METHODS The included patients were treated between July 2010 and March 2016, underwent at least 6 months of follow-up, and presented with a disabling symptom during the first 6 months after GKS that affected their quality of life...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27900916/electrically-evoked-compound-action-potentials-are-different-depending-on-the-site-of-cochlear-stimulation
#7
Paul van de Heyning, Santiago L Arauz, Marcus Atlas, Wolf-Dieter Baumgartner, Marco Caversaccio, Ronel Chester-Browne, Patricia Estienne, Javier Gavilan, Benoit Godey, Wolfgang Gstöttner, Demin Han, Rudolph Hagen, Martin Kompis, Vlad Kuzovkov, Luis Lassaletta, Franc Lefevre, Yongxin Li, Joachim Müller, Lorne Parnes, Andrea Kleine Punte, Christopher Raine, Gunesh Rajan, Adriana Rivas, José Antonio Rivas, Nicola Royle, Georg Sprinzl, Kurt Stephan, Adam Walkowiak, Yuri Yanov, Kim Zimmermann, Patrick Zorowka, Henryk Skarzynski
One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea...
November 30, 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27900329/postinsertional-cable-movements-of-cochlear-implant-electrodes-and-their-effects-on-intracochlear-pressure
#8
I Todt, D Karimi, J Luger, A Ernst, P Mittmann
Introduction. To achieve a functional atraumatic cochlear implantation, intracochlear pressure changes during the procedure should be minimized. Postinsertional cable movements are assumed to induce intracochlear pressure changes. The aim of this study was to observe intracochlear pressure changes due to postinsertional cable movements. Materials and Methods. Intracochlear pressure changes were recorded in a cochlear model with a micro-pressure sensor positioned in the apical region of the cochlea model to follow the maximum amplitude and pressure gain velocity in intracochlear pressure...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27898607/effects-of-intratympanic-dexamethasone-on-high-dose-radiation-ototoxicity-in-vivo
#9
Christine T Dinh, Si Chen, John Dinh, Stefania Goncalves, Esperanza Bas, Kyle Padgett, Perry Johnson, Nagy Elsayyad, Fred Telischi, Thomas Van De Water
BACKGROUND: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. HYPOTHESIS: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. METHODS: Seven rats received radiation (12 Gy) to both cochleae...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27898033/towards-clinical-application-of-neurotrophic-factors-to-the-auditory-nerve-assessment-of-safety-and-efficacy-by-a-systematic-review-of-neurotrophic-treatments-in-humans
#10
REVIEW
Aren Bezdjian, Véronique J C Kraaijenga, Dyan Ramekers, Huib Versnel, Hans G X M Thomeer, Sjaak F L Klis, Wilko Grolman
Animal studies have evidenced protection of the auditory nerve by exogenous neurotrophic factors. In order to assess clinical applicability of neurotrophic treatment of the auditory nerve, the safety and efficacy of neurotrophic therapies in various human disorders were systematically reviewed. Outcomes of our literature search included disorder, neurotrophic factor, administration route, therapeutic outcome, and adverse event. From 2103 articles retrieved, 20 randomized controlled trials including 3974 patients were selected...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27895351/frequency-of-sensorineural-hearing-loss-in-chronic-suppurative-otitis-media
#11
Syed Sajjad Ali Zaidi, Hamdan Ahmed Pasha, Anwar Suhail, Talha Ahmed Qureshi
Chronic suppurative otitis media (CSOM) is defined as chronic otorrhea (i.e., lasting > 6-12 weeks) through a perforated tympanic membrane. It is generally associated with some degree of conductive hearing loss. However, recurrent ear infections due to perforated eardrum result in absorption of toxins and macromolecules into the cochlea leading to sensorineural hearing loss (SNHL). We planned to determine the frequency of sensorineural hearing loss in chronic suppurative otitis media. A descriptive cross-sectional study was conducted at Aga Kgan University Hospital, Karachi, from October 2013 to March 2014...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27893606/cochlear-brainstem-and-psychophysical-responses-show-spectrotemporal-tradeoff-in-human-auditory-processing
#12
Gavin M Bidelman, Shaum P Bhagat
Auditory filter theory posits a tradeoff in time-frequency analysis: high temporal precision is achievable only at the expense of poorer frequency resolution and vice versa. Here, we examined the hierarchy of brain mechanisms of these spectrotemporal tradeoffs through a series of physiological and behavioral measures aimed to tap temporal and spectral acuity at different levels of the auditory neuroaxis (cochlea→brainstem→percept). Cochlear and behavioral frequency selectivity was measured by stimulus-frequency otoacoustic emissions (SFOAE) and psychophysical tuning curves; temporal acuity was measured physiologically and behaviorally by paired click recovery of auditory brainstem responses (ABRs) and gap detection thresholds (GDTs), respectively...
January 1, 2017: Neuroreport
https://www.readbyqxmd.com/read/27891689/deficit-in-acoustic-signal-in-noise-detection-in-glycine-receptor-%C3%AE-3-subunit-knockout-mice
#13
Konstantin Tziridis, Stefanie Buerbank, Volker Eulenburg, Julia Dlugaiczyk, Holger Schulze
Hearing is an essential sense for communication in animals and humans. Normal function of the cochlea of higher vertebrates relies on a fine-tuned interplay of afferent and efferent innervation of both inner and outer hair cells. Efferent inhibition is controlled via olivocochlear feedback loops, mediated mainly by acetylcholine, γ-aminobutyric acid (GABA) and glycine, and is one of the first sites affected by synapto- and neuropathy in the development of hearing loss. While the functions of acetylcholine, GABA, and other inhibitory transmitters within these feedback loops are at least partially understood, especially the function of glycine still remains elusive...
November 27, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27890677/time-course-of-organ-of-corti-degeneration-after-noise-exposure
#14
Barbara A Bohne, Melissa Kimlinger, Gary W Harding
From our permanent collection of plastic-embedded flat preparations of chinchilla cochleae, 22 controls and 199 ears from noise-exposed animals were used to determine when, postexposure, hair cell (HC) and supporting cell (SC) degeneration were completed. The exposed ears were divided into four groups based on exposure parameters: 0.5- or 4-kHz octave band of noise at moderate (M) or high (H) intensities. Postexposure survival ranged from < 1 h to 2.5 y. Ears fixed ≤ 0-12 h postexposure were called ‛acute‛...
November 24, 2016: Hearing Research
https://www.readbyqxmd.com/read/27889918/inner-ear-labyrinth-anatomy-of-monotremes-and-implications-for-mammalian-inner-ear-evolution
#15
Julia A Schultz, Ulrich Zeller, Zhe-Xi Luo
The monophyletic clade Monotremata branches early from the rest of the mammalian crown group in the Jurassic and members of this clade retain many ancestral mammalian traits. Thus, accurate and detailed anatomical descriptions of this group can offer unique insight into the early evolutionary history of Mammalia. In this study, we examine the inner ear anatomy of two extant monotremes, Ornithorhynchus anatinus and Tachyglossus aculeatus, with the primary goals of elucidating the ancestral mammalian ear morphology and resolving inconsistencies found within previous descriptive literature...
November 27, 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27885980/a-revision-surgery-for-cochlear-implantation-in-a-case-of-incomplete-partition-type-i
#16
Habib G Rizk, Francesca Hagood, Meredith A Holcomb, Ted A Meyer
BACKGROUND: Patients with cochlear malformations were long considered poor candidates for cochlear implantation (CI), and surgical approaches different than the standard facial recess approach were used to access the inner ear. There is no previous long-term follow-up of a patient with significantly malformed inner ear operated through an untraditional route and requiring a revision surgery. PURPOSE: This case provides a long-term follow-up from the initial surgery, a short-term follow-up from the revision surgery, and it illustrates the evolving classification of inner ear malformations as well as the potential problems associated with nonstandard approaches to the cochlea...
November 2016: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/27878601/reduction-of-permanent-hearing%C3%A2-loss-by-local-glucocorticoid-application-guinea-pigs-with-acute-acoustic-trauma
#17
M Müller, M Tisch, H Maier, H Löwenheim
BACKGROUND: High-intensity noise exposure from impulse and blast noise events often leads to acute hearing loss and may cause irreversible permanent hearing loss as a long-term consequence. Here, a treatment regime was developed to limit permanent damage based on a preclinical animal model of acute noise trauma. AIM: To develop clinical trials for the treatment of acute noise traumas using approved drugs. The otoprotective potential of glucocorticoids applied locally to the inner ear was examined...
November 23, 2016: HNO
https://www.readbyqxmd.com/read/27878588/the-impact-of-erdosteine-on-cisplatin-induced-ototoxicity-a-proteomics-approach
#18
Sofia Waissbluth, Delphine Garnier, Olubunmi V Akinpelu, Pezhman Salehi, Sam J Daniel
Cisplatin is a commonly used chemotherapeutic agent and causes serious side effects, including progressive and irreversible hearing loss. No treatment is currently available for cisplatin-induced ototoxicity. We have previously demonstrated that erdosteine, a potent antioxidant, partially protected the cochlea against cisplatin toxicity in vivo. The aims of this study were to (1) evaluate the protein profiles of the cochlea following cisplatin administration and (2) evaluate the impact of erdosteine on the protein profile using a proteomics-based approach...
November 23, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27877233/the-impact-of-clinical-stage-on-radiation-doses-to-organs-at-risk-following-intensity-modulated-radiotherapy-in-nasopharyngeal-carcinoma-a-prospective-analysis
#19
Lin Xu, Ji-Jin Yao, Guan-Qun Zhou, Wang-Jian Zhang, Guo-Long Liu, Li-Zhi Liu, Jun Ma, Ying Sun
Background: The development of intensity-modulated radiotherapy (IMRT) has revolutionized the management of nasopharyngeal carcinoma (NPC). The purpose of this study was to investigate the impact of clinical stage on radiation doses to organs at risk (OARs) in NPC. Material and Methods: One hundred and forty-eight patients with newly diagnosed and untreated NPC were prospectively enrolled. Based on the anatomic definition and pathogenesis of radiation induced injury, a total of 28 OARs surrounding the nasopharynx were contoured on axial computed tomography (CT) planning images in each patient...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877041/nanomedicine-strategy-for-optimizing-delivery-to-outer-hair-cells-by-surface-modified-poly-lactic-glycolic-acid-nanoparticles-with-hydrophilic-molecules
#20
Xingxing Wen, Shan Ding, Hui Cai, Junyi Wang, Lu Wen, Fan Yang, Gang Chen
Targeted drug delivery to outer hair cells (OHCs) in the cochlea by nanomedicine strategies forms an effective therapeutic approach for treating hearing loss. Surface chemistry plays a deciding role in nanoparticle (NP) biodistribution, but its influence on such distribution in the cochlea remains largely unknown. Herein, we report the first systematic comparison of poly(lactic/glycolic acid) nanoparticles (PLGA NPs) with or without surface modification of hydrophilic molecules for optimizing the delivery to OHCs both in vitro and in vivo...
2016: International Journal of Nanomedicine
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