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https://www.readbyqxmd.com/read/29239460/guidelines-for-the-treatment-of-lung-cancer-using-radiotherapy
#1
Michael J Chen, Paulo Eduardo Novaes, Rafael Gadia, Rodrigo Motta
No abstract text is available yet for this article.
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238236/pro-gastrin-releasing-peptide-progrp-as-a-biomarker-in-small-cell-lung-cancer-diagnosis-monitoring-and-evaluation-of-treatment-response
#2
REVIEW
Ewa Wojcik, Jan Kanty Kulpa
Lung cancer belongs to malignant tumors that possess the highest rates of morbidity and mortality in the world. A number of morphological, biological and clinical features justify the distinction of small-cell carcinoma with respect to the other histological types of lung cancer. The predominant neuroendocrine phenotype is critical for the selection of biomarkers used in diagnostics, monitoring and evaluation of treatment response; early onset relapses in patients with small-cell lung cancer (SCLC) and the evaluation of their prognosis...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29237906/clinical-efficacy-of-preoperative-vaginal-intracavitary-irradiation-for-stage-ib2-and-iia-cervical-cancer
#3
Fengshuang Li, Yumei Wu, Weimin Kong, Jiandong Wang, Xia Hao, Juwei Niu, Laifu Bai
OBJECTIVE: The purpose of this study was to evaluate the clinical efficacy of preoperative vaginal intracavitary irradiation for Stage Ib2 and IIa cervical cancer. MATERIALS AND METHODS: From June 2008 to June 2014, data from 78 Stage Ib2 and IIa cervical cancer patients (age ≤75 years) with a diameter of local lesions >4 cm were collected in our hospital. Before treatment, all cases were confirmed by biopsy. The patients' general state was good, Karnofsky Performance Score ≥90, heart and lung functioning was normal, and patients were able to tolerate the surgery...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237362/de-novo-malignancies-after-liver-transplantation-a-single-institution-experience
#4
Tufan Egeli, Tarkan Unek, Mucahit Ozbilgin, Cihan Agalar, Serhan Derici, Mesut Akarsu, Ilkay Tugba Unek, Murat Aysin, Aylin Bacakoglu, Ibrahim Astarcıoglu
OBJECTIVES: Our objective was to analyze characteristics, risk factors, and incidence of de novo malignancies after liver transplant. MATERIALS AND METHODS: The hospital records of 557 patients who underwent liver transplant were analyzed from the point of de novo malignancy development. We evaluated the demographic features and survival of these patients retrospectively. RESULTS: The research covered 429 patients, 9 (2%) of whom developed de novo malignancy...
December 14, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29236592/sequencing-of-postoperative-radiotherapy-and-chemotherapy-for-locally-advanced-or-incompletely-resected-non-small-cell-lung-cancer
#5
Samual Francis, Andrew Orton, Greg Stoddard, Randa Tao, Ying J Hitchcock, Wallace Akerley, Kristine E Kokeny
Purpose Although several feasibility studies have demonstrated the safety of adjuvant concurrent chemoradiotherapy (CRT) for locally advanced or incompletely resected non-small-cell lung cancer (NSCLC), it remains uncertain whether this approach is superior to sequential chemotherapy followed by postoperative radiotherapy (C→PORT). We sought to determine the most effective treatment sequence. Patients and Methods Using the National Cancer Database, we selected two cohorts of patients with nonmetastatic NSCLC who had received at least a lobectomy followed by multiagent chemotherapy and radiotherapy; cohort one included patients with R0 resection and pN2 disease, whereas cohort two included patients with R1-2 resection regardless of nodal status...
December 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29234589/retrospective-study-of-predictors-of-bone-metastasis-in-colorectal-cancer-patients
#6
Zhenghong, Zihua Zhu, Guoweijian, Zhangning, Caiyunyun, Yingjiangshan, Xiaomi
Background: We explored risk factors for bone metastasis (BMs) in colorectal cancer (CRC) to improve in early diagnosis and follow-up and to reduce bone metastasis. Methods: With a retrospective analysis of 2066 patients with CRC treated in our institution from January 2006 to January 2015, we assessed high-risk variables associated with bone metastasis using univariate and multivariate analyses. Results: Of those subjects studied, 102 patients developed BMs, including 62 of 1014 the rectal cancer patients and 40 of the 1052 colon cancer patients...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29228994/survival-and-prognostic-factors-of-non-small-cell-lung-cancer-patients-with-postoperative-locoregional-recurrence-treated-with-radical-radiotherapy
#7
Li Ma, Bo Qiu, Jun Zhang, Qi-Wen Li, Bin Wang, Xu-Hui Zhang, Meng-Yun Qiang, Zhao-Lin Chen, Su-Ping Guo, Hui Liu
BACKGROUND: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical radiotherapy. METHODS: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2012 and February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China)...
December 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29224174/cost-effectiveness-of-treatments-for-the-management-of-bone-metastases-a-systematic-literature-review
#8
REVIEW
Lazaros Andronis, Ilias Goranitis, Sue Bayliss, Rui Duarte
BACKGROUND: Metastatic cancers occur when cancer cells break away from the primary tumour. One of the most common sites of metastasis is the bone, with several therapeutic options currently available for managing bone metastases. In a resource-constrained environment, policy makers and practitioners need to know which options are cost effective. OBJECTIVE: The aim of this systematic review was to review and appraise published economic evaluations on treatments for the management of bone metastases...
December 9, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29223987/radiosurgery-for-brain-metastases-changing-practice-patterns-and-disparities-in-the-united-states
#9
Benjamin H Kann, Henry S Park, Skyler B Johnson, Veronica L Chiang, James B Yu
Background: Management of brain metastases typically includes radiotherapy (RT) with conventional fractionation and/or stereotactic radiosurgery (SRS). However, optimal indications and practice patterns for SRS remain unclear. We sought to evaluate national practice patterns for patients with metastatic disease receiving brain RT. Methods: We queried the National Cancer Data Base (NCDB) for patients diagnosed with metastatic non-small cell lung cancer, breast cancer, colorectal cancer, or melanoma from 2004 to 2014 who received upfront brain RT...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223683/a-method-to-combine-target-volume-data-from-3d-and-4d-planned-thoracic-radiotherapy-patient-cohorts-for-machine-learning-applications
#10
Corinne Johnson, Gareth Price, Jonathan Khalifa, Corinne Faivre-Finn, Andre Dekker, Christopher Moore, Marcel van Herk
BACKGROUND AND PURPOSE: The gross tumour volume (GTV) is predictive of clinical outcome and consequently features in many machine-learned models. 4D-planning, however, has prompted substitution of the GTV with the internal gross target volume (iGTV). We present and validate a method to synthesise GTV data from the iGTV, allowing the combination of 3D and 4D planned patient cohorts for modelling. MATERIAL AND METHODS: Expert delineations in 40 non-small cell lung cancer patients were used to develop linear fit and erosion methods to synthesise the GTV volume and shape...
December 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29223641/re-irradiation-for-locally-recurrent-lung-cancer-evidence-risks-and-benefits
#11
R Rulach, G G Hanna, K Franks, J McAleese, S Harrow
In spite of recent improvements in both the technical delivery of radiotherapy and systemic therapy in the treatment of non-small cell lung cancer, local recurrence rates after radiotherapy remain a significant challenge. In the setting of local relapse after radiotherapy, treatments such as surgical resection or radiofrequency ablation are often not appropriate owing to disease and patient factors. Re-irradiation may be a potential treatment option. This overview considers the published evidence and potential treatment strategies...
December 6, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29223410/characteristics-of-computed-tomography-perfusion-parameters-in-non-small-cell-lung-cancer-and-its-relationship-to-histology-size-stage-an-treatment-response
#12
Carmen Trinidad López, Miguel Souto Bayarri, Roque Oca Pernas, Carlos Delgado Sánchez-Gracián, Maria González Vázquez, Antonio Vaamonde Liste, Gonzalo Tardáguila De La Fuente, Javier De La Fuente Aguado
OBJECTIVES: To analyze computed tomography perfusion (CTP) parameters in NSCLC. MATERIALS AND METHODS: Prospective study, 152 patients with NSCLC. CTP parameters were correlated with histology, stage, size and response to conventional chemotherapy/radiotherapy. RESULTS: Neuroendocrine tumours presented higher BV (p 0.002). Negative correlation of PMB (p 0.003) and positive of MTT (p 0.046) with T stage was found. BF showed negative correlation with size...
December 5, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29223168/serious-gastric-perforation-after-second-stereotactic-body-radiotherapy-for-peripheral-lung-cancer-that-recurred-after-initial-stereotactic-body-radiotherapy-a-case-report
#13
Hotaka Nonaka, Hiroshi Onishi, Masatoki Ozaki, Kengo Kuriyama, Takafumi Komiyama, Ryo Saito
BACKGROUND: In recent reports, re-irradiation with stereotactic body radiotherapy for lung tumors in patients previously treated with thoracic radiation therapy resulted in several serious toxicities. Serious non-lung toxicities were observed mostly in patients with central tumors, but we experienced a case of fatal gastric perforation after a second stereotactic body radiotherapy in a patient with a peripheral lung tumor. CASE PRESENTATION: An 83-year-old Asian man was diagnosed with T2N0M0 lung cancer in the form of squamous cell carcinoma in the lower lobe of his left lung...
December 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29221745/upfront-surgery-as-first-line-therapy-in-selected-patients-with-stage-iiia-non-small-cell-lung-cancer
#14
Difan Zheng, Ting Ye, Hong Hu, Yawei Zhang, Yihua Sun, Jiaqing Xiang, Haiquan Chen
OBJECTIVE: Surgery plays an important role in the multidisciplinary treatment strategy for patients with stage IIIA non-small cell lung cancer (NSCLC). Besides induction therapy, patients could benefit from surgery followed by adjuvant chemotherapy and radiotherapy. This study analyzed a subset of patients with pIIIA NSCLC who underwent upfront surgery as first-line therapy. METHODS: Selected patients with pIIIA NSCLC who received upfront surgery were retrospectively analyzed...
November 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29221676/prospective-medical-analysis-of-radiation-therapist-image-repositioning-during-image-guided-radiotherapy
#15
O Lauche, F Castan, H de Forges, C Guillaumon, S Gourgou, P Fenoglietto, N Aillères, D Azria, O Riou
PURPOSE: Radiation oncologists are responsible for deciding which day-to-day variations are acceptable or not in the treatment setup. However, properly qualified and trained radiation therapists might be capable to perform image registration. We evaluated in our centre the capability and accuracy of radiation therapists to validate positioning images in a prospective study. METHODS AND PATIENTS: A total of 84 patients treated for prostate, head and neck, lung or breast cancer was prospectively and randomly included from July 2011 to July 2013 in radiotherapy unit of our institution...
December 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29221323/management-of-non-small-cell-lung-cancer-with-egfr-mutation-the-role-of-radiotherapy-in-the-era-of-tyrosine-kinase-inhibitor-therapy-opportunities-and-challenges
#16
REVIEW
Bing Xia, Shirong Zhang, Shenglin Ma
In recent years, the treatment of advanced non-small cell lung cancer (NSCLC) was greatly promoted by the discovery of oncogenic drivers and the development of targeted therapies specific for these drivers. Somatic mutations in epidermal growth factor receptor (EGFR) are the most common type in patients with NSCLC. Small-molecule tyrosine kinase inhibitor (TKI) targeting EGFR produced relatively high response rate and long duration with acceptable toxicity profile. Also, the life expectancy in patients with active EGFR mutation has been significantly prolonged than the past...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220828/prediction-of-radiation-esophagitis-in-non-small-cell-lung-cancer-using-clinical-factors-dosimetric-parameters-and-pretreatment-cytokine-levels
#17
Peter G Hawkins, Philip S Boonstra, Stephen T Hobson, James A Hayman, Randall K Ten Haken, Martha M Matuszak, Paul Stanton, Gregory P Kalemkerian, Theodore S Lawrence, Matthew J Schipper, Feng-Ming Spring Kong, Shruti Jolly
Radiation esophagitis (RE) is a common adverse event associated with radiotherapy for non-small cell lung cancer (NSCLC). While plasma cytokine levels have been correlated with other forms of radiation-induced toxicity, their association with RE has been less well studied. We analyzed data from 126 patients treated on 4 prospective clinical trials. Logistic regression models based on combinations of dosimetric factors [maximum dose to 2 cubic cm (D2cc) and generalized equivalent uniform dose (gEUD)], clinical variables, and pretreatment plasma levels of 30 cytokines were developed...
December 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29218841/improvement-of-conformal-arc-plans-by-using-deformable-margin-delineation-method-for-stereotactic-lung-radiotherapy
#18
Görkem Güngör, Melek Demir, Gökhan Aydın, Bülent Yapıcı, Banu Atalar, Enis Özyar
PURPOSE: Stereotactic body radiotherapy (SBRT) is an established treatment technique in the management of medically inoperable early stage non-small cell lung cancer (NSCLC). Different techniques such as volumetric modulated arc (VMAT) and three-dimensional conformal arc (DCA) can be used in SBRT. Previously, it has been shown that VMAT is superior to DCA technique in terms of plan evaluation parameters. However, DCA technique has several advantages such as ease of use and considerable shortening of the treatment time...
December 7, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29218271/magnetic-resonance-imaging-in-precision-radiation-therapy-for-lung-cancer
#19
REVIEW
Hannah Bainbridge, Ahmed Salem, Rob H N Tijssen, Michael Dubec, Andreas Wetscherek, Corinne Van Es, Jose Belderbos, Corinne Faivre-Finn, Fiona McDonald
Radiotherapy remains the cornerstone of curative treatment for inoperable locally advanced lung cancer, given concomitantly with platinum-based chemotherapy. With poor overall survival, research efforts continue to explore whether integration of advanced radiation techniques will assist safe treatment intensification with the potential for improving outcomes. One advance is the integration of magnetic resonance imaging (MRI) in the treatment pathway, providing anatomical and functional information with excellent soft tissue contrast without exposure of the patient to radiation...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218269/blood-based-biomarkers-for-precision-medicine-in-lung-cancer-precision-radiation-therapy
#20
REVIEW
Dirk De Ruysscher, Jianyue Jin, Tim Lautenschlaeger, Jin-Xiong She, Zhongxing Liao, Feng-Ming Spring Kong
Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must take into account this variability as well as its dynamic state. The genetic features of the tumor and the host, and increasingly also the epi-genetic and proteomic characteristics, are being unraveled. Multiple techniques, including histological examination, blood sampling, measurement of circulating tumor cells (CTCs), and functional and molecular imaging, can be used for this purpose...
December 2017: Translational Lung Cancer Research
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