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https://www.readbyqxmd.com/read/29912042/pack-cxl-in-reducing-the-time-to-heal-in-suppurative-corneal-ulcers-observations-of-a-pilot-study-from-south-india
#1
Priya Basaiawmoit, Satheesh Solomon T Selvin, Sanita Korah
PURPOSE: To assess the usefulness of photoactivated chromophore for infectious keratitis-corneal collagen cross-linking in reducing the time to heal in suppurative corneal ulcers in a South Indian tertiary care center. METHODS: This was an observational cohort study with 2 arms. In the prospective arm, 13 patients with suppurative corneal ulcers who presented to the outpatient department were recruited. Their ulcers were exposed to ultraviolet-A with riboflavin (B2) (photoactivated chromophore for infectious keratitis-corneal collagen cross-linking) up to a maximum of 4 sittings at 3-day intervals...
June 14, 2018: Cornea
https://www.readbyqxmd.com/read/29910023/accelerated-versus-standard-corneal-collagen-cross-linking-in-pediatric-keratoconus-patients-24-months-follow-up-results
#2
Ozge Sarac, Mehtap Caglayan, Betul Seher Uysal, Ayse Guzin Taslipinar Uzel, Burak Tanriverdi, Nurullah Cagil
PURPOSE: To compare the 24 month visual, refractive, topographic and aberrometric results of the accelerated and standard corneal collagen cross-linking (CXL) in pediatric keratoconus patients. METHODS: 87 eyes of 64 consecutive keratoconus patients under 18 years old with 24 month follow-up period following standard or accelerated CXL were included. 38 eyes received standard CXL (3 Mw/cm2 , 30 min), while 49 eyes had accelerated CXL (9 mW/cm2 , 10 min). Changes in the uncorrected (UCVA) and best corrected visual acuity (BCVA), spherical equivalent (SE), manifest astigmatism (MA), corneal topographic parameters, and corneal aberrations such as spherical aberration (SA), high order aberrations (HOAs), horizontal and vertical coma were evaluated...
June 14, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29903589/-corneal-collagen-cross-linking-to-treat-infectious-keratitis
#3
REVIEW
R Atia, L Jouve, J Knoeri, C Georgeon, L Laroche, V Borderie, N Bouheraoua
Infectious keratitis are a frequent cause of ocular morbidity. Today, new treatments are necessary to combat the emergence of antibiotic resistant germs. Corneal collagen cross-linking has been suggested to treat corneal infectious (PACK-CXL). Its action would be both antimicrobial and protective for the cornea, increasing its biochemical resistence to proteolytic enzymes. In vivo, PACK-CXL might demonstrate good efficacy against bacterial keratitis, contrary to herpetic keratitis for which it is contraindicated...
June 11, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29895115/-the-clinical-study-of-corneal-cross-linking-with-preserved-corneal-epithelial-flap-in-thin-keratoconic-corneas
#4
J J Sun, X J Huang, W Y Shi, T Wang
Objective: To evaluate the therapeutic effect of corneal collagen cross-linking (CXL) with preserved corneal epithelial flap and isotonic riboflavin for treatment of keratoconus eyes with thin corneas. Methods: Prospective case-control study. Twenty two eyes of 20 patients (16 males and 4 females, with age of 23.5±4.9), who have been diagnosed with progressive keratoeonus and the comeal stroma thickness of whom were less than 400μm (without the epithelium), were included in this study. Corneal collagen crosslinking was performed under preserved corneal epithelial flap (8...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29891154/combined-wavefront-guided-transepithelial-photorefractive-keratectomy-and-corneal-crosslinking-for-visual-rehabilitation-in-moderate-keratoconus
#5
Daniel M Gore, Marcello T Leucci, Vijay Anand, Luis Fernandez-Vega Cueto, Samuel Arba Mosquera, Bruce D Allan
PURPOSE: To present 24-month results from the transepithelial photorefractive keratectomy (PRK)-corneal crosslinking (CXL) trial using simultaneous accelerated CXL and a new tissue-saving ocular wavefront-guided transepithelial PRK algorithm aiming to reverse visual loss in early-stage keratoconus without compromise to stabilization of disease progression. SETTING: Moorfields Eye Hospital, London, United Kingdom. DESIGN: Prospective case series...
May 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29889297/long-term-results-of-corneal-cross-linking-for-terrien-s-marginal-degeneration
#6
José Lamarca, Borja Salvador-Culla, Carlos Fernández-Vega, Rafael I Barraquer
PURPOSE: To report the long-term clinical outcomes of a patient with Terrien's marginal degeneration who underwent successful peripheral corneal cross-linking (CXL) to arrest progression. METHODS: Clinical assessment included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corneal topography, anterior segment optical coherence tomography, ultrasonic pachymetry, corneal hysteresis, and corneal resistance factor. Eccentric epithelium-off CXL was performed in both eyes after limbal conjunctival resection...
June 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29889294/corneal-epithelial-remodeling-after-standard-epithelium-off-corneal-cross-linking-in-keratoconic-eyes
#7
Jeferson Lautert, Dharmil Doshi, Francis W Price, Marianne O Price
PURPOSE: To evaluate remodeling of the corneal epithelium after epithelium-off corneal cross-linking (CXL). METHODS: In this prospective single-center study, 93 eyes of 93 patients with progressive keratoconus underwent standard CXL. The maximum keratometry was assessed before and after CXL with Scheimpflug imaging, and the epithelial thickness profile across the central 5 mm of the cornea was assessed with spectral-domain optical coherence tomography anterior segment imaging...
June 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29871966/biomechanical-assessment-of-healthy-and-keratoconic-corneas-with-without-crosslinking-using-dynamic-ultrahigh-speed-scheimpflug-technology-and-the-relevance-of-the-parameter-a1l-a2l
#8
Thomas A Fuchsluger, Susanne Brettl, Gerd Geerling, Wolfgang Kaisers, Philipp Franko Zeitz
AIMS: To examine corneal biomechanics in healthy and keratoconic eyes, with or without crosslinking obtained by ultrahigh-speed Scheimpflug measurements (Corvis ST). METHODS: One hundred and seventeen eyes were studied in three groups: group 1 (n=39) contained keratoconic eyes without crosslinking. Group 2 (CXL; n=28) comprised keratoconic eyes after crosslinking. These were compared with a control group (n=50 matched healthy eyes). In addition, 10 keratoconus patients, before and after CXL treatment, respectively, were examined...
June 5, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862655/comparison-of-corneal-collagen-cross-linking-pack-cxl-and-voriconazole-treatments-in-experimental-fungal-keratitis
#9
Hüseyin Baran Özdemir, Ayşe Kalkancı, Kamil Bilgihan, Pınar Uyar Göçün, Betül Öğüt, Funda Karakurt, Merve Erdoğan
PURPOSE: To compare the antifungal efficacy of corneal collagen cross-linking with photoactivated riboflavin (PACK-CXL) and voriconazole in experimental Fusarium solani and Candida albicans keratitis models. METHODS: Sixty-four corneas of 32 New Zealand rabbits were included and divided into two main groups. Intrastromal injection of Fusarium and Candida suspensions was performed, and it was observed that keratitis was formed on the third day. Both groups were randomly separated into the following four groups: control, PACK-CXL, voriconazole and PACK-CXL combined with voriconazole...
June 4, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29804113/optimizing-genipin-concentration-for-corneal-collagen-cross-linking-an-ex-vivo-study
#10
Almutez M Gharaibeh, Virginia Saez, Nerea Garcia, Laurent Bataille, Jorge L Alió
PURPOSE: Studying genipin variable concentrations, treatment durations, and delivery methods as a substance to increase corneal stiffness by inducing corneal collagen cross-linking (CXL). MATERIALS AND METHODS: 100 bovine corneas treated with different genipin concentrations (0.1, 0.5, and 1%) and treatment durations (15 min, 40 min, 2 h, and 3 days) through different delivery methods compared to 10 controls treated with riboflavin/UV. Histology examination, enzymatic digestion with collagenase and thermal differential scanning calorimetry were performed on the different samples...
May 25, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29778454/influence-of-the-beam-profile-crosslinking-setting-on-changes-in-corneal-topography-and-tomography-in-progressive-keratoconus-preliminary-results
#11
Robert Herber, Kathleen S Kunert, Věra Veliká, Eberhard Spoerl, Lutz E Pillunat, Frederik Raiskup
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included...
May 16, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778118/erratum
#12
(no author information available yet)
METHODS: …The systems were the Paracel/Vibex Xtra, comprising riboflavin 0.25% solution containing TRIS and ethylenediaminetetraacetic acid and an isotonic solution of riboflavin 0.25%, (Group 1) and the CXLO system (Group 2)…. RESULTS: The mean riboflavin fluorescence intensity grades in Group 2 (4 eyes) were 3.8, 4.8, and 4.8 at 10, 15, and 20 minutes, respectively. The mean grades in Group 1 (3 eyes) were 2.0, 2.3, and 2.0, respectively. The riboflavin distribution was uniform in Group 2 but not in Group 1...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29778107/photorefractive-intrastromal-corneal-crosslinking-for-treatment-of-myopic-refractive-error-findings-from-12-month-prospective-study-using-an-epithelium-off-protocol
#13
Matthias Elling, Inga Kersten-Gomez, H Burkhard Dick
PURPOSE: To assess the long-term effectiveness and safety of photorefractive intrastromal corneal crosslinking (CXL) in patients with low myopia. SETTING: Ruhr University Eye Hospital, Bochum, Germany. DESIGN: Prospective case series. METHODS: Healthy eyes with myopia were treated with photorefractive intrastromal CXL using the Mosaic System. Riboflavin 0.1% solution (VibeX Rapid) was topically administered, followed by 365 nm ultraviolet-A (30 mW/cm2 ) irradiance...
April 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29777678/uva-riboflavin-collagen-crosslinking-stiffening-effects-on-anterior-and-posterior-corneal-flaps
#14
Hamed Hatami-Marbini, Sandeep M Jayaram
The UVA/riboflavin collagen crosslinking (CXL) is one of the treatment procedure for stopping the progression of keratoconus. The inclusion criterion for this procedure is a minimum corneal thickness of 400 μm, which is not often met in patients with advanced keratoconus. Preoperatively swelling of thin corneas was shown to stabilize the keratectasia without any postoperative endothelial damage. Recently, we have shown that swelling porcine corneas prior to the CXL treatment had no significant effect on the resulting improvement in their tensile properties...
May 16, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29771883/-transepithelial-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#15
A I Kopaenko, N V Ivanova
PURPOSE: To assess the effectiveness of transepithelial collagen crosslinking (CXL) in patients with keratoconus. MATERIAL AND METHODS: The study involved 44 patients (44 eyes) with stage I-II progressive keratoconus. Patients were divided into two groups. The 1st group included 22 patients that had underwent transepithelial CXL. The 2nd group included 22 patients that had underwent traditional CXL. RESULTS AND DISCUSSION: All patients of the group 2 all patients had corneal syndrome, which lasted 2-4 days...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29753555/evaluation-of-early-postoperative-ocular-pain-after-photorefractive-keratectomy-and-corneal-crosslinking
#16
Siamak Zarei-Ghanavati, Soheyla Jafarpour, Alireza Radyn-Majd, Hamed Hosseinikhah-Manshadi
PURPOSE: To evaluate and compare early postoperative pain after photorefractive keratectomy (PRK) and corneal crosslinking (CXL). SETTING: Khatam-al-Anbia Eye Hospital, Mashhad, Iran. DESIGN: Prospective case series. METHODS: The PRK group included patients with simple refractive errors whereas the CXL group included patients with clinical keratoconus. The groups were compared regarding the level of pain based on the visual analogue scale (VAS), verbal rating scale (VRS), and Wong-Baker FACES pain rating scale immediately after surgery, 6 hours postoperatively, and 1, 3, and 7 days postoperatively...
May 9, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29750010/comparative-analysis-of-safety-and-efficacy-of-photorefractive-keratectomy-versus-photorefractive-keratectomy-combined-with-crosslinking
#17
Gitansha Shreyas Sachdev, Shreyas Ramamurthy, Ramamurthy Dandapani
Purpose: To assess the safety, efficacy, and refractive predictability of half-fluence accelerated corneal collagen crosslinking (CXL) applied concurrently with photorefractive keratectomy (PRK), and compare the results to standard PRK. Setting: Refractive Services, The Eye Foundation, Coimbatore, India. Design: Interventional comparative case series. Methods: Patients seeking refractive correction for myopia or myopic astigmatism were included in the study...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29746325/corneal-cross-linking-in-pediatric-patients-evaluating-treated-and-untreated-eyes-5-year-follow-up-results
#18
Lior Or, Assaf Rozenberg, Adi Abulafia, Isaac Avni, David Zadok
PURPOSE: To evaluate the long-term results of corneal collagen cross-linking (CXL) for treatment of pediatric keratoconus and the long-term outcomes of the fellow untreated keratoconic eye in patients younger than 18 years old. METHODS: A retrospective case analysis was performed on 88 eyes of 44 patients aged 18 years or younger, with keratoconus, who underwent CXL in at least 1 eye. Follow-up measurements, for the treated and untreated eye pair, taken up to 5 years after treatment, were compared with baseline values...
May 3, 2018: Cornea
https://www.readbyqxmd.com/read/29738594/bilateral-asymmetric-keratoconus-induced-by-thyrotoxicosis-with-long-term-stability-after-corneal-cross-linking
#19
Ramon Lee, Ahmed El-Massry, Youssef El-Massry, J Bradley Randleman
PURPOSE: To present a case of bilateral, asymmetric keratoconus presenting unilaterally after partial thyroidectomy with delayed presentation in the second eye after thyrotoxicosis, with disease stabilization following corneal cross-linking (CXL). METHODS: Case report and literature review. RESULTS: A 17-year-old girl with a history of Graves' disease underwent partial thyroidectomy without thyroid hormone replacement therapy with normal baseline ophthalmic examination of corrected distance visual acuity (CDVA) of 20/20 and no manifest astigmatism in either eye...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29738584/corneal-allogenic-intrastromal-ring-segments-cairs-combined-with-corneal-cross-linking-for-keratoconus
#20
Soosan Jacob, Shaila R Patel, Amar Agarwal, Arvind Ramalingam, A I Saijimol, John Michael Raj
PURPOSE: To describe a new technique for the treatment of keratoconus using corneal allogenic intrastromal ring segments (CAIRS). METHODS: CAIRS trephined from donor cornea using a double-bladed trephine were implanted into mid-depth femtosecond laser-dissected channels in the cornea of patients with keratoconus in the 6.5-mm optic zone, followed by accelerated corneal cross-linking (A-CXL)-either conventional or contact lens-assisted CXL (A-CACXL), depending on minimum corneal thickness...
May 1, 2018: Journal of Refractive Surgery
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