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https://www.readbyqxmd.com/read/29471090/structure-characterization-of-two-functional-polysaccharides-from-polygonum-multiflorum-and-its-immunomodulatory
#1
Qing Zhang, Yi Xu, Junjiang Lv, Mengxia Cheng, Ying Wu, Kun Cao, Xiaofeng Zhang, Xiuni Mou, Qi Fan
Two purified polysaccharides named WPMP-1 and WPMP-2 were obtained from Polygonum multiflorum with an average molecular weight of 2.04 kDa and 92.13 kDa, respectively. Structural characterization revealed that WPMP-1was supposed to be a glucan composed of 1,4-linked α-d-Glcp, 1,4,6-linked α-d-Glcp, and terminal α-d-Glcp. WPMP-2 contained a complex branched structre formed by 1,2-linked α-d-Rhap, 1,2,4-linked α-d-Rhap, 1,3,5-linked α-l-Ara, 1,5- linked α-l-Araf, terminal α-l-Araf, 1,4-linked β-d-Galp, 1,4-linked α-d-GalpA, and 4-linked α-d-GalpA...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29467891/prognostic-analysis-of-hepatocellular-carcinoma-on-the-background-of-liver-cirrhosis-via-contrast-enhanced-ultrasound-and-pathology
#2
Yukai He, Fenghua Liu, Shaofeng Mou, Qingyan Li, Sikui Wang
The aim of this study was to analyze the correlation between the quantitative parameters of contrast-enhancement ultrasound for primary hepatocellular carcinoma (HCC) and biological manifestations of tumor (Ki-67), and to explore the related risk factors of primary hepatocellular carcinoma, so as to provide the theoretical basis for the further study on contrast-enhancement ultrasound manifestations, clinical features and prognosis of HCC. The patients with HCC confirmed by operation or puncture were collected, and those with the background of liver cirrhosis and immunohistochemical staining for tumor sample sections were selected...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467378/inform-software-a-semi-automated-research-tool-to-identify-presumptive-human-hepatic-progenitor-cells-and-other-histological-features-of-pathological-significance
#3
Anne S Kramer, Bruce Latham, Luke A Diepeveen, Lingjun Mou, Geoffrey J Laurent, Caryn Elsegood, Laura Ochoa-Callejero, George C Yeoh
Hepatic progenitor cells (HPCs) play an important regenerative role in acute and chronic liver pathologies. Liver disease research often necessitates the grading of disease severity, and pathologists' reports are the current gold-standard for assessment. However, it is often impractical to recruit pathologists in large cohort studies. In this study we utilise PerkinElmer's "InForm" software package to semi-automate the scoring of patient liver biopsies, and compare outputs to a pathologist's assessment...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463377/a-portable-multi-channel-turbidity-system-for-rapid-detection-of-pathogens-by-loop-mediated-isothermal-amplification
#4
Zhu Chen, Tong Yang, Haowen Yang, Taotao Li, Libo Nie, Xianbo Mou, Yan Deng, Nongyue He, Zhiyang Li, Lijun Wang, Song Li
This study aimed at developing a portable multi-channel turbidity system (21 cm in length, 15.5 cm in width and 11.5 cm in depth) by real-time loop-mediated isothermal amplification (LAMP) method for rapid detection of pathogens. The developed system herein includes temperature control unit, photoelectric detection unit, turbidity calibration unit, power management unit, human machine unit, communication unit and ARM-based microcontroller. The coefficient of variation for eight channels is less than 0.25% in noise analysis...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29459890/promoting-local-ownership-lessons-learned-from-process-of-transitioning-clinical-mentoring-of-hiv-care-and-treatment-in-ethiopia
#5
Getnet M Kassie, Teklu Belay, Anjali Sharma, Getachew Feleke
Introduction: Focus on improving access and quality of HIV care and treatment gained acceptance in Ethiopia through the work of the International Training and Education Center for Health. The initiative deployed mobile field-based teams and capacity building teams to mentor health care providers on clinical services and program delivery in three regions, namely Tigray, Amhara, and Afar. Transitioning of the clinical mentoring program (CMP) began in 2012 through capacity building and transfer of skills and knowledge to local health care providers and management...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29455311/accelerated-molecular-breeding-of-a-novel-p-tgms-line-with-broad-spectrum-resistance-to-rice-blast-and-bacterial-blight-in-two-line-hybrid-rice
#6
Jiaming Mi, Dabing Yang, Yi Chen, Jiefeng Jiang, Haipeng Mou, Junbin Huang, Yidan Ouyang, Tongmin Mou
BACKGROUND: Breeding two-line hybrid rice with disease resistance is an effective approach to stabilize rice yield in commercial rice production of China. RESULTS: We improved the blast and bacterial blight resistance of Guangzhan63-4S, an elite photoperiod- and thermo-sensitive male sterile (P/TGMS) line widely used in two-line hybrid rice, by introducing the R genes Pi2 and Xa7 conferring resistance to rice blast and bacterial blight, respectively. Through the backcrossing and gene pyramiding breeding coupled with molecular marker-assisted selection, a new P/TGMS line Hua1228S carrying Pi2, Xa7, and tms5 was developed...
February 17, 2018: Rice
https://www.readbyqxmd.com/read/29446740/role-of-immune-cells-in-diabetic-kidney-disease
#7
Xiaoqian Yang, Shan Mou
Diabetic kidney disease (DKD) is one of the major complications of diabetes mellitus (DM) and is currently the most common cause of end-stage renal disease (ESRD) worldwide. Traditionally, DKD is considered a disease which has nothing to do with the immune system, and the pathogenesis is mainly characterized to be metabolic disturbance. Recent growing evidence indicates immunologic and inflammatory mechanisms in the development and progression of DKD. This overview of macrophages, dendritic cells, T lymphocytes, B lymphocytes, neutrophils and mast cells is closely involved in the pathologic process of DKD, with more emphasis on the leucocyte accumulation and related molecular mechanisms...
February 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29440729/enhanced-nonlinear-characteristics-with-the-assistance-of-a-formula-see-text-symmetric-trimer-system
#8
Lei Du, Yan Zhang, Chu-Hui Fan, Yi-Mou Liu, Feng Gao, Jin-Hui Wu
We study the parity-time (PT) symmetry characteristics and the applications to nonlinear optics in an optical trimer system consisting of two indirectly coupled standing-mode micro-cavities and a two-level quantum emitter (QE) placed at the intersection of two cavities. We find this trimer system can exhibit analogical phenomena as those in typical [Formula: see text]-symmetric dimer systems composed of a passive cavity directly coupled to an active cavity. This system, whose [Formula: see text] symmetry is demonstrated by our analytic results, can be transformed between the [Formula: see text]-symmetric phase and the [Formula: see text]-broken phase by adjusting relevant system parameters...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440474/neuroprotective-effects-of-magl-monoacylglycerol-lipase-inhibitors-in-experimental-ischemic-stroke
#9
Sang-Ho Choi, Allison L Arai, Yongshan Mou, Byeongteck Kang, Cecil Chern-Chyi Yen, John Hallenbeck, Afonso C Silva
BACKGROUND AND PURPOSE: MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins-substances that mediate tissue inflammatory response. Here, we have studied the effects of the selective MAGL inhibitors JZL184 and MJN110 and their underlying molecular mechanisms on 3 different experimental models of focal cerebral ischemia. METHODS: SHR (spontaneously hypertensive rats) and normotensive WKY (Wistar Kyoto) rats were subject to an intracortical injection of the potent vasoconstrictor endothelin-1, permanent occlusion of a distal segment of the middle cerebral artery via craniectomy, or transient occlusion of the middle cerebral artery by the intraluminal suture method...
February 13, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29439359/effects-of-combining-high-and-low-frequency-repetitive-transcranial-magnetic-stimulation-on-upper-limb-hemiparesis-in-the-early-phase-of-stroke
#10
Hua Long, Hongbin Wang, Chenguang Zhao, Qiang Duan, Feng Feng, Nan Hui, Li Mao, Huiling Liu, Xiang Mou, Hua Yuan
BACKGROUND: Both high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) and low-frequency rTMS (LF-rTMS) are reported to benefit upper limb motor function rehabilitation in patients with stroke. However, the efficacy of combining LF- and HF-rTMS (LF-HF rTMS) has not been adequately explored, especially in the early phase of stroke. OBJECTIVE: To compare the effects of LF- and LF-HF rTMS on the upper limb motor function in the early phase post stroke...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29434604/increased-interleukin-23-in-hashimoto-s-thyroiditis-disease-induces-autophagy-suppression-and-reactive-oxygen-species-accumulation
#11
Tingting Zheng, Chengcheng Xu, Chaoming Mao, Xiao Mou, Fei Wu, Xuefeng Wang, Ling Bu, Yuepeng Zhou, Xuan Luo, Qingyan Lu, Hongli Liu, Guoyue Yuan, Shengjun Wang, Deyu Chen, Yichuan Xiao
Hashimoto's thyroiditis (HT) represents the most common organ-specific autoimmune disease. Inflammatory factors and reactive oxygen species (ROS) play detrimental roles during the pathogenesis of HT. In this study, we found that thyroid follicular cells (TFCs) from HT patients expressed an elevated level of interleukin-23 (IL-23), which contributed to autophagy suppression and ROS accumulation. Additionally, IL-23-induced autophagy suppression and ROS accumulation in human TFCs was attributed to AKT/mTOR/NF-κB signaling pathway activation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29434452/-pik3ca-and-tp53-mutations-predict-overall-survival-of-stage-ii-iii-colorectal-cancer-patients
#12
A-Jian Li, Hua-Guang Li, Er-Jiang Tang, Wei Wu, Ying Chen, Hui-Hong Jiang, Mou-Bin Lin, Lu Yin
AIM: To investigate the predictive value of PIK3CA and TP53 mutation status in colorectal cancer (CRC) patients treated with 5-fluorouracil-based chemotherapy. METHODS: In this study, a total of 315 patients with histologically proven CRC were enrolled from Yangpu Hospital affiliated to Shanghai Tongji University between 2007 and 2011. Of these patients, 241 with stage II/III CRC received 5-fluorouracil-based adjuvant chemotherapy. Formalin-fixed paraffin-embedded lesion samples of the patients with curatively resected CRC were collected...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29434336/comparative-transcriptomics-provides-novel-insights-into-the-mechanisms-of-selenium-tolerance-in-the-hyperaccumulator-plant-cardamine-hupingshanensis
#13
Yifeng Zhou, Qiaoyu Tang, Meiru Wu, Di Mou, Hui Liu, Shouchuang Wang, Chi Zhang, Li Ding, Jie Luo
Selenium (Se) is an essential mineral element for animals and humans. Cardamine hupingshanensis (Brassicaceae), found in the Wuling mountain area of China, has been identified as a novel Se hyperaccumulator plant. However, the mechanism for selenium tolerance in Cardamine plants remains unknown. In this study, two cDNA libraries were constructed from seedlings of C. hupingshanensis treated with selenite. Approximately 100 million clean sequencing reads were de novo assembled into 48,989 unigenes, of which 39,579 and 33,510 were expressed in the roots and leaves, respectively...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432832/new-utilization-of-polygonum-multiflorum-polysaccharide-as-macromolecular-carrier-of-5-fluorouracil-for-controlled-release-and-immunoprotection
#14
Qing Zhang, Yi Xu, Junjiang Lv, Mengxia Cheng, Ying Wu, Kun Cao, Xiaofeng Zhang, Xiuni Mou, Qi Fan
WPMP-2 is an acid polysaccharide isolated from Polygonum multiflorum, which demonstrated excellent immunomodulatory activity. In order to reduce immunosuppression of 5-fluorouracil (5-Fu), WPMP-2 was utilized as a macromolecular carrier to conjugate the 5-Fu derivatives 5-fluorouracil-1-acetic acid (5-FUAC) through ester bond. The conjugate showed controlled drug release behaviour in vitro at 37 °C in phosphate buffer (pH 7.4), and only 5-FUAC was detected in the media. The cytotoxicity test in vitro showed that the conjugate exhibited different cytotoxicity to HepG-2 and HT-29 cells...
February 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29432004/measuring-interfacial-polymerization-kinetics-using-microfluidic-interferometry
#15
Arash Nowbahar, Vincent Mansard, Jodi M Mecca, Mou Paul, Tina Arrowood, Todd M Squires
A range of academic and industrial fields exploit interfacial polymerization in producing fibers, capsules and films. Although widely used, measurements of reaction kinetics remain challenging and rarely reported, due to film thinness and reaction rapidity. Here, polyamide film formation is studied using microfluidic interferometry, measuring monomer concentration profiles near the interface during the reaction. Our results reveal the reaction is initially controlled by a reaction-diffusion boundary layer within the organic phase, which allows the first measurements of the rate constant for this system...
February 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29430727/the-sda-and-cad-glycan-antigens-and-their-glycosyltransferase-%C3%AE-1-4galnact-ii-in-xenotransplantation
#16
REVIEW
Chengjiang Zhao, David K C Cooper, Yifan Dai, Hidetaka Hara, Zhiming Cai, Lisha Mou
Antibody-mediated rejection is a barrier to the clinical application of xenotransplantation, and xenoantigens play an important role in this process. Early research suggested that N-acetyl-D-galactosamine (GalNAc) could serve as a potential xenoantigen. GalNAc is the immunodominant glycan of the Sda antigen. Recently, knockout of β1,4-N-acetylgalactosaminyltransferase 2 (β1,4GalNAcT-II) from the pig results in a decrease in binding of human serum antibodies to pig cells. It is believed that this is the result of the elimination of the GalNAc on the Sda antigen, which is catalyzed by the enzyme, β1,4GalNAcT-II...
February 11, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29430584/succession-sequence-of-lactic-acid-bacteria-driven-by-environmental-factors-and-substrates-throughout-the-brewing-process-of-shanxi-aged-vinegar
#17
Yu Zheng, Jun Mou, Jiwei Niu, Shuai Yang, Lin Chen, Menglei Xia, Min Wang
Lactic acid bacteria (LAB) are essential microbiota for the fermentation and flavor formation of Shanxi aged vinegar, a famous Chinese traditional cereal vinegar that is manufactured using open solid-state fermentation (SSF) technology. However, the dynamics of LAB in this SSF process and the underlying mechanism remain poorly understood. Here, the diversity of LAB and the potential driving factors of the entire process were analyzed by combining culture-independent and culture-dependent methods. Canonical correlation analysis indicated that ethanol, acetic acid, and temperature that result from the metabolism of microorganisms serve as potential driving factors for LAB succession...
February 11, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29428676/controlled-release-of-collagen-binding-sdf-1%C3%AE-from-the-collagen-scaffold-promoted-tendon-regeneration-in-a-rat-achilles-tendon-defect-model
#18
Jie Sun, Chenchen Mou, Qin Shi, Bing Chen, Xianglin Hou, Wen Zhang, Xiaoran Li, Yan Zhuang, Jiajia Shi, Yanyan Chen, Jianwu Dai
It had been demonstrated that stromal cell-derived factor-1α (SDF-1α) could promote in situ tendon regeneration by recruiting endogenous cells. However, native SDF-1α diffuses too fast in vivo, reducing its local concentration and efficacy. In this study, we prepared a recombinant SDF-1α containing a collagen-binding domain (CBD-SDF-1α) and developed a functional collagen scaffold by tethering CBD-SDF-1α on the collagen scaffold for in situ tendon regeneration. CBD-SDF-1α could induce the migration of mesenchymal stem cells, dermal fibroblasts and Achilles tendon fibroblasts in vitro, and achieve controlled release from the collagen scaffold...
February 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29425020/nature-inspired-2d-mosaic-3d-gradient-mesoporous-framework-bimetal-oxide-dual-composite-strategy-toward-ultra-stable-and-high-capacity-lithium-storage
#19
Jia Yu, Yanlei Wang, Lihui Mou, Daliang Fang, Shimou Chen, Suojiang Zhang
In allusion to traditional transition metal oxide (TMO) anodes for lithium-ion batteries, which face with severe volume variation and poor conductivity, herein a bimetal oxide dual-composite strategy based on 2D-mosaic 3D-gradient design is proposed. Inspired by natural mosaic-dominance phenomena, Zn1-xCoxO/ZnCo2O4 2D-mosaic-hybrid mesoporous ultrathin nanosheets serve as building blocks to assemble into a 3D Zn-Co-gradient hierarchical framework. Moreover, a series of derivative frameworks with highly evolution are controllably synthesized, based on which a facile one-pot synthesis process can be developed...
February 9, 2018: ACS Nano
https://www.readbyqxmd.com/read/29424165/-treatment-for-acute-ankle-joint-injuries
#20
Xiao-Jun Liang, Hong-Mou Zhao
No abstract text is available yet for this article.
June 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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