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https://www.readbyqxmd.com/read/29044816/zinc-catalyzed-hydrosilylation-copolymerization-of-aromatic-dialdehydes-with-diphenylsilane
#1
Chuanyang Li, Xiufang Hua, Zehuai Mou, Xinli Liu, Dongmei Cui
The hydrosilylation reaction of diphenylsilane and phthalaldehyde is catalyzed by heteroscorpionate zinc hydride complex LZnH (1, L = ((Me) Pz)2 CP(Ph)2 NPh, (Me) Pz = 3,5-dimethylpyrazolyl). Both terephthalaldehyde (tPAA) and isophthalaldehyde (iPAA) affords linear polymer; however, when PAA is used, a seven-membered cyclic silyl ether is formed. These products are characterized by (1) H and (13) C NMR spectra. Other properties of polymers are determined by gel permeation chromatography (GPC)-multiangle laser-light scattering, differential scanning calorimetry, and thermogravimetry...
October 17, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29041983/pak5-mediated-phosphorylation-and-nuclear-translocation-of-nf-%C3%AE%C2%BAb-p65-promotes-breast-cancer-cell-proliferation-in-vitro-and-in-vivo
#2
Ying-Chun Zhang, Fu-Chun Huo, Lu-Lu Wei, Chan-Chan Gong, Yao-Jie Pan, Jie Mou, Dong-Sheng Pei
BACKGROUND: Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that the signal pathways of p21(cdc42/rac1)-activated kinase 5 (PAK5) have been found in various tumor progression, however, the role of PAK5 in breast cancer remains largely unclear. METHODS: We evaluated PAK5 and p65 staining in breast cancer tissues (BCTs) and paired non-cancerous tissues (NTs) using tissue microarray (TMA) technology...
October 17, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29040216/depressive-symptoms-screening-in-postmenopausal-women-with-symptomatic-pelvic-organ-prolapse
#3
Fangfang Ai, Mou Deng, Meng Mao, Tao Xu, Lan Zhu
OBJECTIVE: This study aimed to investigate the prevalence of depressive symptoms in postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify the factors associated with depressive symptoms in this population. METHODS: We conducted a cross-sectional study involving postmenopausal women with symptomatic POP who visited the Center of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, between July 2016 and March 2017...
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#4
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
October 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038456/incomplete-ionization-of-a-110%C3%A2-mev-unintentional-donor-in-%C3%AE-ga2o3-and-its-effect-on-power-devices
#5
Adam T Neal, Shin Mou, Roberto Lopez, Jian V Li, Darren B Thomson, Kelson D Chabak, Gregg H Jessen
Understanding the origin of unintentional doping in Ga2O3 is key to increasing breakdown voltages of Ga2O3 based power devices. Therefore, transport and capacitance spectroscopy studies have been performed to better understand the origin of unintentional doping in Ga2O3. Previously unobserved unintentional donors in commercially available [Formula: see text] Ga2O3 substrates have been electrically characterized via temperature dependent Hall effect measurements up to 1000 K and found to have a donor energy of 110 meV...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038164/pka-creb-signaling-prevents-adriamycin-induced-podocyte-apoptosis-via-upregulation-of-mitochondrial-respiratory-chain-complexes
#6
Kewei Xie, Mingli Zhu, Peng Xiang, Xiaohuan Chen, Ayijiaken Kasimumali, Renhua Lu, Qin Wang, Shan Mou, Zhaohui Ni, Leyi Gu, Huihua Pang
Previous work showed that the activation of protein kinase A (PKA) signaling promoted mitochondrial fusion and prevented podocyte apoptosis. The cAMP response element binding protein (CREB) is the main downstream transcription factor of PKA signaling. Herein, we show that the pKA-agonist pCPT-cAMP prevented the production of adriamycin (ADR)-induced reactive oxygen species and apoptosis in podocytes, which were inhibited by CREB RNAi. The activation of PKA enhanced mitochondrial function and prevented the ADR-induced decrease of mitochondrial respiratory chain complex I subunits, NADH-ubiquinone oxidoreductase complex (ND) 1/3/4 genes, and protein expression...
October 16, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29036800/quantitative-parameters-of-contrast-enhanced-ultrasonography-for-assessment-of-renal-pathology-a-preliminary-study-in-chronic-kidney-disease
#7
Wen-Qi Yang, Shan Mou, Yao Xu, Li Xu, Feng-Hua Li, Hong-Li Li
No abstract text is available yet for this article.
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29035673/extracellular-pyridine-nucleotides-as-immune-elicitors-in-arabidopsis
#8
Zhonglin Mou
The pyridine nucleotides nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP) are coenzymes that function in both metabolic reactions and intracellular signaling. Emerging evidence from animal research indicates that NAD(P) also acts in the extracellular space (ECS). We have shown in the model plant Arabidopsis that (1) exogenous NAD(P) induces immune responses, (2) pathogen infection causes leakage of intracellular NAD(P) into the extracellular fluid at concentrations sufficient to induce immune responses, and (3) removal of extracellular NAD(P) [eNAD(P)] by expressing the human NAD(P)-metabolizing ectoenzyme CD38 partially compromises systemic acquired resistance...
October 16, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29034940/near-infrared-light-and-ph-responsive-au-carbon-calcium-phosphate-nanoparticles-for-imaging-and-chemo-photothermal-cancer-therapy-of-cancer-cells
#9
Huiyuan Wang, Manjie Zhang, Lingyu Zhang, Shengnan Li, Lu Li, Xiliang Li, Min Yu, Zhongcheng Mou, Tingting Wang, Chungang Wang, Zhongmin Su
A simple, mild and reproducible synthetic route was developed to fabricate the multifunctional Au@carbon/calcium phosphate core-shell nanoparticles (Au@C/CaP NPs), which act as an efficient nanoplatform for pH/near-infrared (NIR) dual-responsive drug delivery, X-ray computed tomography (CT) imaging and synergistic chemo-photothermal cancer therapy in vitro.
October 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29029335/cortical-reorganization-in-dual-innervation-by-single-peripheral-nerve
#10
Mou-Xiong Zheng, Yun-Dong Shen, Xu-Yun Hua, Ao-Lin Hou, Yi Zhu, Wen-Dong Xu
BACKGROUND: Functional recovery after peripheral nerve injury and repair is related with cortical reorganization. However, the mechanism of innervating dual targets by 1 donor nerve is largely unknown. OBJECTIVE: To investigate the cortical reorganization when the phrenic nerve simultaneously innervates the diaphragm and biceps. METHODS: Total brachial plexus (C5-T1) injury rats were repaired by phrenic nerve-musculocutaneous nerve transfer with end-to-side (n = 15) or end-to-end (n = 15) neurorrhaphy...
September 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29027951/effects-of-maternal-low-energy-diet-during-gestation-on-intestinal-morphology-disaccharidase-activity-and-immune-response-to-lipopolysaccharide-challenge-in-pig-offspring
#11
Yuling Chen, Daolin Mou, Liang Hu, Jie Zhen, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Bin Feng, Jian Li, De Wu
Maternal nutrition during gestation is involved in the offspring's intestinal development and immunity. The aim of this study was to (1) determine the effects of maternal energy on intestinal digestion and absorption function in offspring, using pigs as a model; and (2) to evaluate the potential effect and mechanisms of maternal energy in modulating immune responses of lipopolysaccharide (LPS)-challenged piglets. After mating, thirty-six nine-parity sows (Landrace × Yorkshire), body weight (BW) (initial body weight 233...
October 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29018263/phyllomeroterpenoids-a-c-multi-biosynthetic-pathway-derived-meroterpenoids-from-the-tcm-endophytic-fungus-phyllosticta-sp-and-their-antimicrobial-activities
#12
Heng-Gang Yang, Huan Zhao, Jiao-Jiao Li, Shao-Meng Chen, Lang-Ming Mou, Jian Zou, Guo-Dong Chen, Sheng-Ying Qin, Chuan-Xi Wang, Dan Hu, Xin-Sheng Yao, Hao Gao
Phyllomeroterpenoids A-C (1-3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4-9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1-3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus)...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016443/development-and-validation-of-taiwanese-version-of-the-neck-disability-index
#13
Yi-Jing Lue, Chung-Hwan Chen, Shih-Hsiang Chou, Chih-Lung Lin, Kuang-I Cheng, Yen-Mou Lu
STUDY DESIGN: Cross-cultural adaptation and cross-sectional psychometric testing in a convenience sample of patients with neck pain. OBJECTIVE: To translate and cross-culturally adapt the Neck Disability Index (NDI) into a Taiwanese version and to assess the psychometric properties. SUMMARY OF BACKGROUND DATA: The Taiwanese NDI has not been developed or validated. METHODS: The NDI was first translated and culturally adapted to the Taiwanese version...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28994286/a-novel-derivative-of-bardoxolone-methyl-improves-safety-for-treatment-of-diabetic-nephropathy
#14
Zhangjian Huang, Yi Mou, Xiaojun Xu, Di Zhao, Yisheng Lai, Yuwen Xu, Cen Chen, Ping Li, Sixun Peng, Jide Tian, Yihua Zhang
Currently, no effective and safe medicines are available to treat diabetic nephropathy (DN). Bardoxolone methyl (CDDO-Me) has displayed promising anti-DN activity but serious side-effects in the clinical trial, probably because the highly reactive α-cyano-α,β-unsaturated ketone (CUK) in ring A of CDDO-Me can covalently bind to thiol functionalities in many biomacromolecules. In this study, we designed and synthesized a γ-glutamyl transpeptidase (GGT)-based and CUK-modified derivative 2 of CDDO-Me to address this issue...
October 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28992100/prenatal-exposure-to-lps-alters-the-intrarenal-ras-in-offspring-which-is-ameliorated-by-adipose-tissue-derived-mesenchymal-stem-cells
#15
Xian-Fei Ding, Mou Sun, Fang-Xia Guan, Li-Na Guo, Yan-Yan Zhang, You-Dong Wan, Xiao-Juan Zhang, Yan-Wu Yu, Shan-Shan Ma, Hai-Mu Yao, Rui Yao, Rui-Fang Zhang, Tong-Wen Sun, Quan-Cheng Kan
BACKGROUND: Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cells (ADSCs) can ameliorate the effects of prenatal LPS exposure in rat offspring. METHODS: Sixty-four pregnant rats were randomly divided into 4 groups (n = 16 in each), namely, a control group and an LPS group, which were intraperitoneally injected with vehicle and 0...
July 15, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28987656/meta-analysis-of-dual-energy-computed-tomography-virtual-non-calcium-imaging-to-detect-bone-marrow-edema
#16
Mou Li, Yali Qu, Bin Song
OBJECTIVE: This meta-analysis aimed to evaluate the accuracy of dual-energy CT (DECT) virtual non-calcium (VNC) imaging for the detection of bone marrow edema (BME). METHODS: A systematic literature search up to March 2017 was performed to find relevant original studies. Two reviewers independently selected studies, assessed literature quality, and extracted data. Pooled sensitivity, specificity, area under receiver operating characteristic (AUROC) curve, and other measures of DECT accuracy for detecting BME were calculated using random effects models...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28985339/a-re-sequencing-based-ultra-dense-genetic-map-reveals-a-gummy-stem-blight-resistance-associated-gene-in-cucumis-melo
#17
Zhongyuan Hu, Guancong Deng, Haipeng Mou, Yuhui Xu, Li Chen, Jinghua Yang, Mingfang Zhang
The melon (Cucumis melo) genome and genetic maps with hundreds to thousands of single nucleotide polymorphism markers were recently released. However, a high-resolution genetic map was lacking. Gummy stem blight (Gsb) is a destructive disease responsible for considerable economic losses during melon production. We herein describe the development of an ultra-dense genetic map consisting of 12,932 recombination bin markers covering 1,818 cM, with an average distance of 0.17 cM between adjacent tags. A comparison of the genetic maps for melon, watermelon, and cucumber revealed chromosome-level syntenic relationships and recombination events among the three Cucurbitaceae species...
September 7, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28981411/z-index-parameterization-zip-for-volumetric-ct-image-reconstruction-via-3d-dictionary-learning
#18
Ti Bai, Hao Yan, Xun Jia, Steve Jiang, Ge Wang, Xuanqin Mou
Despite the rapid developments of x-ray cone-beam CT (CBCT), image noise still remains a major issue for the low dose CBCT. To suppress the noise effectively while retain the structures well for low dose CBCT image, in this work, a sparse constraint based on the 3D dictionary is incorporated into a regularized iterative reconstruction framework, defining the 3DDL method. In addition, by analyzing the sparsity level curve associated with different regularization parameters, a new adaptive parameter selection strategy is proposed to facilitate our 3DDL method...
October 5, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28978161/thymosin-%C3%AE-4-inhibits-proliferation-and-induces-apoptosis-of-hepatic-stellate-cells-through-pi3k-akt-pathway
#19
Lili Zhu, Mingliang Cheng, Yongmei Liu, Yumei Yao, Zixin Zhu, Baofang Zhang, Qiuju Mou, Yiju Cheng
Liver fibrosis is a necessary stage for chronic liver diseases, and serious threat to human health. Hepatic fibrosis is a necessary stage for chronic liver diseases. Hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Thymosin beta 4 (Tβ4) has a potential role in the pathogenesis of liver fibrosis and that it is especially associated with the activation of HSCs, however, the underlying mechanisms are not fully elucidated. Herein, we investigated the potential role of Tβ4 in liver fibrosis by describing the effects of Tβ4, and we discuss the possible signaling pathway regulated by Tβ4...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977916/synergistic-interaction-between-galectin-3-and-carcinoembryonic-antigen-promotes-colorectal-cancer-metastasis
#20
Keng-Liang Wu, Eng-Yen Huang, Wen-Ling Yeh, Chang-Chun Hsiao, Chung-Mou Kuo
In this study, we investigated the role of galectin-3 and carcinoembryonic antigen (CEA) in metastasis and survival of colorectal cancer (CRC) patients. CEA interacted with galectin-3 at the cell surface and cytoplasm of Caco2 and DLD1 CRC cells. Knocking down galectin-3 did not affect CEA expression in CRC cells. However, there was a dose-dependent increase in CRC cell migration upon addition of small amounts of exogenous CEA (≤1ng/ml). Galectin-3 knockdown blocked induction of CRC cell migration by CEA, suggesting interaction between galectin-3 and CEA was necessary for CRC cell migration...
September 22, 2017: Oncotarget
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