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https://www.readbyqxmd.com/read/29663399/multidimensional-analyses-of-the-learning-curve-for-single-incision-plus-one-port-laparoscopic-surgery-for-sigmoid-colon-and-upper-rectal-cancer
#1
Junmeng Li, Yanan Wang, Dong Liu, Haipeng Zhou, Tingyu Mou, Guoxin Li, Haijun Deng
BACKGROUND AND OBJECTIVES: Single-incision plus one port surgery (SILS + 1) provides the advantages of being minimally invasive and easier to perform than pure single-incision laparoscopic surgery. The aim of this study was to investigate the learning curve (LC) for SILS + 1 for sigmoid colon and upper rectal cancer. METHOD: From November 2012 to May 2014, a series of 85 consecutive patients underwent selective SLIS + 1 for sigmoid colon and upper rectal cancer performed by a single surgeon at Nanfang Hospital...
April 17, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29656941/submucosal-gland-myoepithelial-cells-are-reserve-stem-cells-that-can-regenerate-mouse-tracheal-epithelium
#2
Thomas J Lynch, Preston J Anderson, Pavana G Rotti, Scott R Tyler, Adrianne K Crooke, Soon H Choi, Daniel T Montoro, Carolyn L Silverman, Weam Shahin, Rui Zhao, Chandler W Jensen-Cody, Andrea Adamcakova-Dodd, T Idil Apak Evans, Weiliang Xie, Yulong Zhang, Hongmei Mou, B Paul Herring, Peter S Thorne, Jayaraj Rajagopal, Charles Yeaman, Kalpaj R Parekh, John F Engelhardt
The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airway repair-basal cells in the surface airway epithelium (SAE) and an unknown submucosal gland (SMG) cell type. Whether a lineage relationship exists between these two stem cell compartments remains unclear. Using lineage tracing of glandular myoepithelial cells (MECs), we demonstrate that MECs can give rise to seven cell types of the SAE and SMGs following severe airway injury. MECs progressively adopted a basal cell phenotype on the SAE and established lasting progenitors capable of further regeneration following reinjury...
April 6, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29655605/physiology-and-pathophysiology-of-renal-erythropoietin-producing-cells
#3
REVIEW
Hong-Mou Shih, Chih-Jen Wu, Shuei-Liong Lin
Anemia is a common complication and contributes to increased morbidity and mortality in chronic kidney disease (CKD) patients. Whereas there has been a significant improvement of understanding the underlying mechanism of erythropoiesis, the treatment of renal anemia is still restricted to erythropoietin (EPO)-stimulating agents. The purpose of this article is to review the physiology of erythropoiesis, functional role of EPO and underlying molecular and cellular basis that regulate EPO production. Regulation of EPO production is at mRNA level...
April 11, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29650287/structure-activity-relationship-study-of-a-series-of-caspase-inhibitors-containing-%C3%AE-amino-acid-moiety-for-treatment-of-cholestatic-liver-disease
#4
Jianfeng Mou, Songliang Wu, Zhi Luo, Fengying Guo, Haiying He, Jianhua Wang, Fusen Lin, Fengxun Guo, Jianping Sun, Liang Shen, Minggao Zeng, Chuan Wang, Deming Xu, Zhengxian Gu, Xin Tian, Aiming Zhang, Hongjiang Xu, Ling Yang, Xiquan Zhang, Jian Li, Shuhui Chen
A series of caspase inhibitors containing γ-amino acid moiety have been synthesized. A systemic study on their structure-activity relationship of anti-apoptotic cellular activity is presented. These efforts led to the discovery of compound 20o as a potent caspase inhibitor, which demonstrated preclinical ameliorating total bilirubin efficacy with a significantly improved pharmacokinetic profile.
April 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29649740/design-synthesis-cytotoxicity-and-mechanism-of-novel-dihydroartemisinin-coumarin-hybrids-as-potential-anti-cancer-agents
#5
Haonan Yu, Zhuang Hou, Ye Tian, Yanhua Mou, Chun Guo
To develop novel agents with anticancer activities, thirty-four new dihydroartemisinin-coumarin hybrids were designed and synthesized in this study. Those compounds were identified that had great anticancer activity against two cancer cell lines (MDA-MB-231 and HT-29). The structure-activity relationships of the derivatives were also discussed, and the results of docking analysis had shown that carbonic anhydrases IX (CA IX) was very likely to be one of the drug targets of the hybrids. Meanwhile, to clarify the mechanism of the anticancer activity of the hybrids molecule, we did further exploration in the bioactivity of the hybrids...
April 3, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29649594/detection-of-human-parvovirus-b19-infection-in-the-thymus-of-patients-with-thymic-hyperplasia-associated-myasthenia-gravis
#6
Li Gong, Yanhong Li, Xinyi Li, Qian Tu, Xiaorong Mou, Shumei Wang, Yi Wan, Qiang Lu, Juzheng Wang, Wendong Zhang, Shaojun Zhu, Xiujuan Han, Li Yao, Jiarui Zhang, Gaosheng Huang, Wei Zhang
OBJECTIVE: To investigate the association between human parvovirus B19 (B19V) infection in the thymus and myasthenia gravis (MG). METHODS: The presence of human B19V DNA and protein was assessed in 138 samples, including 68 thymic hyperplasia (39 with MG), 58 thymoma (23 with MG), and 12 normal thymus tissues, by nested polymerase chain reaction, immunohistochemistry, laser capture microdissection, and sequencing in a double-blinded manner. RESULTS: B19V DNA was mainly detected in thymic hyperplasia, and the positive rate (41...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29625314/polybrominated-diphenyl-ethers-in-the-dissolved-and-suspended-phases-of-seawater-from-sanggou-bay-east-china
#7
Wei Ge, Yanan Mou, Chao Chai, Yan Zhang, Jinye Wang, Ting Ju, Tao Jiang, Bin Xia
The levels and profiles of polybrominated diphenyl ethers (PBDEs) in dissolved phase (DP) and suspended particulate matter (SPM) in seawater of Sanggou Bay (SGB) in four seasons were determined. The distribution and potential sources of these compounds were analyzed, and the ecological risk was assessed. The total concentrations of 14 PBDEs (∑14 PBDE) in DP and SPM in the surface water ranged from 0.10 ng L-1 to 2.20 ng L-1 and from 0.51 ng L-1 to 6.15 ng L-1 , respectively. The highest value was obtained in August...
March 28, 2018: Chemosphere
https://www.readbyqxmd.com/read/29624761/two-electron-multicentre-pancake-bonding-in-%C3%AF-stacked-trimers-in-a-salt-of-tetrachloroquinone-anion
#8
Kresimir Molcanov, Zhongyu Mou, Miklos Kertesz, Biserka Kojic-Prodic, Dietmar Stalke, Serhiy Demeshko, Ana Santic, Vladimir Stilinovic
The crystal structure of [4-damp])2[Cl4Q]3 (4-damp = 4-dimethylamino-N-methylpyridinium, Cl4Q = tetrachloroquinone) salt is built up from slipped columnar stacks of quinoid rings composed of closely bound trimers with the intra-trimer separation distance of 2.84 Å and total charge of -2 whereas the inter-trimer distance is 3.59 Å. The individual rings exhibit partial negative charges that are distributed unevenly among the three Cl4Qs in the trimer. The strong interactions within a trimer (Cl4Q)32- have a partially covalent character with two-electrons / multi-centered bonding, that is extended over three rings, plausibly termed as 'pancake bonding'...
April 6, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29623933/electroacupuncture-and-moxibustion-promote-regeneration-of-injured-sciatic-nerve-through-schwann-cell-proliferation-and-nerve-growth-factor-secretion
#9
Lin-Na Hu, Jin-Xin Tian, Wei Gao, Jing Zhu, Fang-Fang Mou, Xiao-Chun Ye, Yu-Pu Liu, Ping-Ping Lu, Shui-Jin Shao, Hai-Dong Guo
Using electroacupuncture and moxibustion to treat peripheral nerve injury is highly efficient with low side effects. However, the electroacupuncture- and moxibustion-based mechanisms underlying nerve repair are still unclear. Here, in vivo and in vitro experiments uncovered one mechanism through which electroacupuncture and moxibustion affect regeneration after peripheral nerve injury. We first established rat models of sciatic nerve injury using neurotomy. Rats were treated with electroacupuncture or moxibustion at acupoints Huantiao (GB30) and Zusanli (ST36)...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29617293/wide-baseline-stereo-based-obstacle-mapping-for-unmanned-surface-vehicles
#10
Xiaozheng Mou, Han Wang
This paper proposes a wide-baseline stereo-based static obstacle mapping approach for unmanned surface vehicles (USVs). The proposed approach eliminates the complicated calibration work and the bulky rig in our previous binocular stereo system, and raises the ranging ability from 500 to 1000 m with a even larger baseline obtained from the motion of USVs. Integrating a monocular camera with GPS and compass information in this proposed system, the world locations of the detected static obstacles are reconstructed while the USV is traveling, and an obstacle map is then built...
April 4, 2018: Sensors
https://www.readbyqxmd.com/read/29615900/peripheral-cb1-receptor-neutral-antagonist-am6545-ameliorates-hypometabolic-obesity-and-improves-adipokine-secretion-in-monosodium-glutamate-induced-obese-mice
#11
Haiming Ma, Guina Zhang, Chunrong Mou, Xiujuan Fu, Yadan Chen
Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal obesity, and combined with dyslipidemia and insulin resistance. 3-Week AM6545 treatment dose-dependently decreased the body weight, intraperitoneal fat mass, and rectified the accompanied dyslipidemia include elevated serum triglyceride, total cholesterol, free fatty acids, and lowered LDLc level...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29615004/laparoscopy-assisted-colectomy-as-an-oncologically-safe-alternative-for-patients-with-stage-t4-colon-cancer-a-propensity-matched-cohort-study
#12
Hao Wang, Xiaoyu Chen, Hao Liu, Tingyu Mou, Haijun Deng, Liying Zhao, Guoxin Li
BACKGROUND: It is still controversial whether laparoscopy-assisted colectomy (LAC) is suitable for patients with stage T4 colon cancer. This study aimed to compare the short- and long-term outcomes of LAC and open colectomy (OC) for patients with pathologic T4 colon cancer. METHODS: Data of eligible patients with colon cancer in our institution from March 2004 to September 2014 were retrospectively reviewed. The patients were followed up to September 2016. Propensity score matching was performed to control the bias...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29614611/-characterization-analysis-of-gm-gl-genes-of-varicella-zoster-virus-in-six-provinces-of-china
#13
J J Mou, M Y Qi, C S Li, H Y Zheng, M Chen, J H Zhou, J L He, W W Xu, S T Xu, X G Xu
Objective: To analyze the genetic characterization of glycoprotein M(gM.),glycoprotein L(gL) of varicella zoster virus. Methods: According to the program of "Ministry of Science and Technology of China" , Based on the 12 suspected VZV patients monitored in Beijing (1 case), Shanghai (5 cases), Jilin (2 cases), Qinghai (1 case), Guangdong (2 case) and Sichuan (case) in 2007-2015. A total of 12 Vesicle fluid and throat swab samples were collected. Positive samples were identified by Agarose gel electrophoresis and two glycoprotein genes were amplified by polymerase chain reaction (PCR)...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29607031/fine-root-responses-to-temporal-nutrient-heterogeneity-and-competition-in-seedlings-of-two-tree-species-with-different-rooting-strategies
#14
Peng Wang, Meng Shu, Pu Mou, Jacob Weiner
There is little direct evidence for effects of soil heterogeneity and root plasticity on the competitive interactions among plants. In this study, we experimentally examined the impacts of temporal nutrient heterogeneity on root growth and interactions between two plant species with very different rooting strategies: Liquidambar styraciflua (sweet gum), which shows high root plasticity in response to soil nutrient heterogeneity, and Pinus taeda (loblolly pine), a species with less plastic roots. Seedlings of the two species were grown in sandboxes in inter- and intraspecific combinations...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29605655/how-do-3-month-old-infants-attribute-preferences-to-a-human-agent
#15
You-Jung Choi, Yi Mou, Yuyan Luo
The current study showed that 3-month-old infants attributed a preference to a human agent, with her face and upper body visible, when she consistently reached for and grasped one of two objects with her bare hand. In contrast, infants did not appear to interpret the agent's same actions of grasping the object as indicative of her preference when it was the only object present or when it hid the other object from her but not from the infants. These results suggest that even from an early age, infants interpret human agents' actions in terms of mental states such as goals and preferences...
March 29, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29601511/the-height-adaptive-parameterized-step-length-measurement-method-and-experiment-based-on-motion-parameters
#16
Yanshun Zhang, Yingyue Li, Chuang Peng, Dong Mou, Ming Li, Wei Wang
In order to tackle the inaccurate step length measurement of people with different heights and in different motion states, a height-adaptive method of step length measurement based on motion parameters is proposed in this paper. This method takes people's height, stride frequency, and changing accelerometer output while walking into integrated consideration, and builds a dynamic and parameterized model of their step length. In this study, these parameters were calibrated with thirty sets of experiment data from people with different heights and in different motion states, which were then verified experimentally by motion data of randomly selected subjects, regardless of speed and height...
March 30, 2018: Sensors
https://www.readbyqxmd.com/read/29588618/immunocompetence-and-mechanism-of-the-dribble-dcs-vaccine-for-oral-squamous-cell-carcinoma
#17
Heng Dong, Hang Su, Lin Chen, Kai Liu, Hong-Ming Hu, Weidong Yang, Yongbin Mou
Background: Due to the high-quality immunogenicity of tumor-derived autophagosomes (DRibbles), we aimed to explore the antitumor ability and mechanism of DRibble-loaded dendritic cells (DRibble-DCs). Materials and methods: DRibbles extracted from the oral squamous cell carcinoma cell line SCC7 express specific LC3-II and ubiquitination marker. Immunization of mice with the DRibble-DCs vaccine led to the proliferation and differentiation of CD3+ CD4+ IFN-γ+ and CD3+ CD8+ IFN-γ+ T cells...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29587142/developmental-history-provides-a-roadmap-for-the-emergence-of-tumor-plasticity
#18
Purushothama Rao Tata, Ryan D Chow, Srinivas Vinod Saladi, Aleksandra Tata, Arvind Konkimalla, Anne Bara, Daniel Montoro, Lida P Hariri, Angela R Shih, Mari Mino-Kenudson, Hongmei Mou, Shioko Kimura, Leif W Ellisen, Jayaraj Rajagopal
We show that the loss or gain of transcription factor programs that govern embryonic cell-fate specification is associated with a form of tumor plasticity characterized by the acquisition of alternative cell fates normally characteristic of adjacent organs. In human non-small cell lung cancers, downregulation of the lung lineage-specifying TF NKX2-1 is associated with tumors bearing features of various gut tissues. Loss of Nkx2-1 from murine alveolar, but not airway, epithelium results in conversion of lung cells to gastric-like cells...
March 26, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29587139/quality-before-quantity-inspecting-cftr
#19
Hongmei Mou
CFTR biosynthesis is highly dynamic. In this issue of Developmental Cell, Okiyoneda et al. (2018) show that RFFL serves as a CFTR conformation scrutinizer at the plasma membrane. It recognizes misfolded CFTR proteins and marks them for degradation. This quality control mechanism may be explored to benefit cystic fibrosis patients.
March 26, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29584724/developing-a-buruli-ulcer-community-of-practice-in-bankim-cameroon-a-model-for-buruli-ulcer-outreach-in-africa
#20
Paschal Kum Awah, Alphonse Um Boock, Ferdinand Mou, Joseph Tohnain Koin, Evaristus Mbah Anye, Djeunga Noumen, Mark Nichter
BACKGROUND: In the Cameroon, previous efforts to identify Buruli ulcer (BU) through the mobilization of community health workers (CHWs) yielded poor results. In this paper, we describe the successful creation of a BU community of practice (BUCOP) in Bankim, Cameroon composed of hospital staff, former patients, CHWs, and traditional healers. METHODS AND PRINCIPLE FINDINGS: All seven stages of a well-defined formative research process were conducted during three phases of research carried out by a team of social scientists working closely with Bankim hospital staff...
March 27, 2018: PLoS Neglected Tropical Diseases
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