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https://www.readbyqxmd.com/read/28732166/mel-n16-a-series-of-novel-endomorphin-analogs-with-good-analgesic-activity-and-a-favorable-side-effect-profile
#1
Xin Liu, Long Zhao, Yuan Wang, Jingjing Zhou, Dan Wang, Yixin Zhang, Xianghui Zhang, Zhaojuan Wang, Dongxu Yang, Lingyun Mou, Rui Wang
Opioid peptides are neuromodulators that bind to opioid receptors and reduce pain sensitivity. Endomorphins are one of the most active endogenous opioid peptides, and they have good affinity and selectivity toward the μ opioid receptor. However, their clinical usage is hindered by their inability to cross the blood-brain barrier, and their poor in vivo activity after peripheral injection. In order to overcome these defects, we have designed and synthesized a series of novel endomorphin analogs with multiple site modifications...
July 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28731115/the-synthesis-of-cycloalka-b-furans-via-an-au-i-catalyzed-tandem-reaction-of-3-yne-1-2-diols
#2
Wei-Ting Liu, Zheng-Liang Xu, Xue-Qing Mou, Bang-Hong Zhang, Wen Bao, Shao-Hua Wang, Dongjun Lee, Lin-Sheng Lei, Kun Zhang
An Au(i)-catalyzed cyclization/1,2-rearrangement/aromatization cascade of 3-yne-1,2-diols has been successfully realized. This reaction not only provides a new and efficient strategy for the synthesis of substituted cycloalka[b]furan compounds as well as their derivatives, but might also facilitate related biological studies.
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28726297/iodine-promoted-semmler-wolff-reactions-step-economic-access-to-meta-substituted-primary-anilines-via-aromatization
#3
Shi-Ke Wang, Xia You, Da-Yuan Zhao, Neng-Jie Mou, Qun-Li Luo
An atom and step economic access to unprotected meta-substituted primary anilines was disclosed via the Semmler-Wolff reaction promoted by molecular iodine, in which noble metal catalysts and inert atmosphere are unnecessary while the forcing reaction conditions and the lengthy synthesis can be avoided. The synthetic utility of this approach is evident in the de novo syntheses of three bioactive molecules with good total yields.
July 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28723634/synergistic-interaction-between-galectin-3-and-carcinoembryonic-antigen-promotes-colorectal-cancer-metastasis
#4
Keng-Liang Wu, Eng-Yen Huang, Wen-Ling Yeh, Chang-Chun Hsiao, Chung-Mou Kuo
In this study, we investigated the role of galectin-3 and carcinoembryonic antigen (CEA) in metastasis and survival of colorectal cancer (CRC) patients. CEA interacted with galectin-3 at the cell surface and cytoplasm of Caco2 and DLD1 CRC cells. Knocking down galectin-3 did not affect CEA expression in CRC cells. However, there was a dose-dependent increase in CRC cell migration upon addition of small amounts of exogenous CEA (≤1ng/ml). Galectin-3 knockdown blocked induction of CRC cell migration by CEA, suggesting interaction between galectin-3 and CEA was necessary for CRC cell migration...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722654/a-lectin-receptor-kinase-as-a-potential-sensor-for-extracellular-nicotinamide-adenine-dinucleotide-in-arabidopsis-thaliana
#5
Chenggang Wang, Mingqi Zhou, Xudong Zhang, Jin Yao, Yanping Zhang, Zhonglin Mou
Nicotinamide adenine dinucleotide (NAD(+)) participates in intracellular and extracellular signaling events unrelated to metabolism. In animals, purinergic receptors are required for extracellular NAD(+) (eNAD(+)) to evoke biological responses, indicating that eNAD(+) may be sensed by cell-surface receptors. However, the identity of eNAD(+)-binding receptors still remains elusive. Here, we identify a lectin receptor kinase (LecRK), LecRK-I.8, as a potential eNAD(+) receptor in Arabidopsis. The extracellular lectin domain of LecRK-I...
July 19, 2017: ELife
https://www.readbyqxmd.com/read/28720425/toward-best-practices-for-surgical-morbidity-and-mortality-conferences-a-mixed-methods-study
#6
Marit S de Vos, Perla J Marang-van de Mheen, Ann D Smith, Danny Mou, Edward E Whang, Jaap F Hamming
OBJECTIVE: To assess formats for surgical morbidity and mortality conferences (M&M) for strengths and challenges. DESIGN: A mixed methods approach with local observations to assess key domains of M&M practice (i.e., goals, structure, and process/content) and surveys to assess participants' expectations and experiences. SETTING: Surgical departments of two teaching hospitals (Boston, USA and Leiden, Netherlands). PARTICIPANTS: Participants of surgical M&M, including attending surgeons, residents, physician assistants, and medical students (total n = 135)...
July 15, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28719625/differences-of-immune-disorders-between-alzheimer-s-disease-and-breast-cancer-based-on-transcriptional-regulation
#7
Wei Kong, Xiaoyang Mou, Jin Deng, Benteng Di, Ruxing Zhong, Shuaiqun Wang, Yang Yang, Weiming Zeng
Although chronic inflammation and immune disorders are of great importance to the pathogenesis of both dementia and cancer, the pathophysiological mechanisms are not clearly understood. In recent years, growing epidemiological evidence and meta-analysis data suggest an inverse association between Alzheimer's disease (AD), which is the most common form of dementia, and cancer. It has been revealed that some common genes and biological processes play opposite roles in AD and cancer; however, the biological immune mechanism for the inverse association is not clearly defined...
2017: PloS One
https://www.readbyqxmd.com/read/28716277/comparison-of-hematoma-density-heterogeneity-and-ultraearly-hematoma-growth-in-predicting-hematoma-expansion-in-patients-with-spontaneous-intracerebral-hemorrhage
#8
Zhiyuan Yu, Lu Ma, Jun Zheng, Rui Guo, Mou Li, Xiaoze Wang, Sen Lin, Hao Li, Chao You
BACKGROUND: Hematoma density heterogeneity (HDH) and ultraearly hematoma growth (uHG) are novel imaging predictors for hematoma expansion (HE) based on computed tomography (CT). This study was aimed to compare the accuracy of HDH and uHG in HE prediction within a cohort of spontaneous intracerebral hemorrhage (sICH) patients. METHODS: This study included sICH patients with initial CT within 6h after onset. uHG was defined as baseline hematoma volume/onset-to-CT time (ml/h) and the cutoff was 4...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714288/tolterodine-treatment-of-women-with-overactive-bladder-syndrome-comparison-of-night-time-and-daytime-dosing-for-nocturia
#9
Ko-Hsin Tsai, Sheng-Mou Hsiao, Ho-Hsiung Lin
AIM: We aimed to clarify the impact of night-time dosing with tolterodine extended release (ER) on nocturia. METHODS: The bladder diaries, urodynamic studies, and medical records of female patients with overactive bladder syndrome who were diagnosed between January 2005 and December 2015, and treated with tolterodine ER 4 mg once per day (night-time or daytime dosing) for 12 weeks in the urogynecology outpatient clinics of two tertiary referral centers were reviewed retrospectively...
July 16, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28708319/experimental-study-on-ablation-of-leiomyoma-by-combination-high-intensity-focused-ultrasound-and-iodized-oil-in-vitro
#10
Zhi-Gang Liang, Yi Gao, Xiao-Yan Ren, Cui Sun, Heng-Fang Gu, Meng Mou, Yan-Bing Xiao
AIM: The aim of the current study was to investigate whether iodized oil (IO) enhances high-intensity focused ultrasound (HIFU) ablation of uterine leiomyoma and to determine the features of hyperechoic changes in the target region. METHODS: Forty samples of uterine leiomyoma were randomly divided into an experimental group and a control group. In the experimental group, the leiomyoma was ablated by HIFU 30 min after 1 mL of iodized oil had been injected into the center of the myoma...
July 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28707696/zinc-promoted-cyclization-of-tosylhydrazones-and-2-dimethylamino-malononitrile-an-efficient-strategy-for-the-synthesis-of-substituted-1-tosyl-1h-pyrazoles
#11
Bang-Hong Zhang, Lin-Sheng Lei, Si-Zhan Liu, Xue-Qing Mou, Wei-Ting Liu, Shao-Hua Wang, Jie Wang, Wen Bao, Kun Zhang
A Zn(OTf)2-promoted cyclization reaction of tosylhydrazones with 2-(dimethylamino)malononitrile has been successfully developed providing an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.
July 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28706496/the-mediation-effect-of-coping-style-on-the-relations-between-personality-and-life-satisfaction-in-chinese-adolescents
#12
Le Xu, Ru-De Liu, Yi Ding, Xiaohong Mou, Jia Wang, Ying Liu
Previous findings showed the associations between each of the Big Five personality trait and adolescents' life satisfaction were different. Some traits (extraversion and neuroticism) correlated with adolescents' life satisfaction, while other traits did not have the same associations with adolescents' life satisfaction. In order to explain why the Big Five traits differed in their associations with adolescents' life satisfaction, the present study verified the relations between each of the Big Five personality traits and life satisfaction, and demonstrated the mediating effects of coping style on the relations between these personality traits and life satisfaction in a sample of 2,357 Chinese adolescents...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28706431/pancreatic-t-histiocyte-rich-large-b-cell-lymphoma-a-case-report-and-review-of-literature
#13
Shu-Mei Zheng, De-Jiang Zhou, Yi-Hua Chen, Rui Jiang, Yun-Xia Wang, Yong Zhang, Hong-Li Xue, Hai-Qiong Wang, Dong Mou, Wei-Zheng Zeng
Primary pancreatic lymphoma (PPL) is an extremely rare form of extranodal malignant lymphoma. The most common histological subtype of PPL is diffuse large B cell lymphoma (DLBCL). In rare cases, PPL can also present as follicular lymphoma, small lymphocytic lymphoma, and T cell lymphoma either of non-Hodgkin's lymphoma or of Hodgkin's lymphoma. T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL) is an uncommon morphologic variant of DLBCL with aggressive clinical course, it is predominantly a nodal disease, but extranodal sites such as bone marrow, liver, and spleen can be involved...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28700350/thymosin-%C3%AE-4-inhibits-proliferation-and-induces-apoptosis-of-hepatic-stellate-cells-through-pi3k-akt-pathway
#14
Lili Zhu, Mingliang Cheng, Yongmei Liu, Yumei Yao, Zixin Zhu, Baofang Zhang, Qiuju Mou, Yiju Cheng
Liver fibrosis is a necessary stage for chronic liver diseases, and serious threat to human health. Hepatic fibrosis is a necessary stage for chronic liver diseases. Hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Thymosin beta 4 (Tβ4) has a potential role in the pathogenesis of liver fibrosis and that it is especially associated with the activation of HSCs, however, the underlying mechanisms are not fully elucidated. Herein, we investigated the potential role of Tβ4 in liver fibrosis by describing the effects of Tβ4, and we discuss the possible signaling pathway regulated by Tβ4...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697578/data-correlation-based-noise-level-estimation-for-cone-beam-projection-data
#15
Ti Bai, Hao Yan, Luo Ouyang, David Staub, Jing Wang, Xun Jia, Steve B Jiang, Xuanqin Mou
BACKGROUND: In regularized iterative reconstruction algorithms, the selection of regularization parameter depends on the noise level of cone beam projection data. OBJECTIVE: Our aim is to propose an algorithm to estimate the noise level of cone beam projection data. METHODS: We first derived the data correlation of cone beam projection data in the Fourier domain, based on which, the signal and the noise were decoupled. Then the noise was extracted and averaged for estimation...
July 7, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28697339/oncogenic-activation-of-the-rna-binding-protein-nelfe-and-myc-signaling-in-hepatocellular-carcinoma
#16
Hien Dang, Atsushi Takai, Marshonna Forgues, Yotsowat Pomyen, Haiwei Mou, Wen Xue, Debashish Ray, Kevin C H Ha, Quaid D Morris, Timothy R Hughes, Xin Wei Wang
Global transcriptomic imbalance is a ubiquitous feature associated with cancer, including hepatocellular carcinoma (HCC). Analyses of 1,225 clinical HCC samples revealed that a large numbers of RNA binding proteins (RBPs) are dysregulated and that RBP dysregulation is associated with poor prognosis. We further identified that oncogenic activation of a top candidate RBP, negative elongation factor E (NELFE), via somatic copy-number alterations enhanced MYC signaling and promoted HCC progression. Interestingly, NELFE induces a unique tumor transcriptome by selectively regulating MYC-associated genes...
July 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28694815/co-overexpression-of-the-constitutively-active-form-of-osbzip46-and-aba-activated-protein-kinase-sapk6-improves-drought-and-temperature-stress-resistance-in-rice
#17
Yu Chang, Ba Hoanh Nguyen, Yongjun Xie, Benze Xiao, Ning Tang, Wenliu Zhu, Tongmin Mou, Lizhong Xiong
Drought is one of the major abiotic stresses threatening rice (Oryza sativa) production worldwide. Drought resistance is controlled by multiple genes, and therefore, a multi-gene genetic engineering strategy is theoretically useful for improving drought resistance. However, the experimental evidence for such a strategy is still lacking. In this study, a few drought-responsive genes from rice were assembled by a multiple-round site-specific assembly system, and the constructs were introduced into the rice cultivar KY131 via Agrobacterium-mediated transformation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28694465/generation-of-complement-protein-c3-deficient-pigs-by-crispr-cas9-mediated-gene-targeting
#18
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions. However, the delineation of pathological and physiological roles of C3 has been hampered by the insufficiency of suitable animal models. In the present study, we applied the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system to target the C3 gene in porcine fetal fibroblasts...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693414/hypothetical-protein-cpn0423-triggers-nod2-activation-and-contributes-to-chlamydia-pneumoniae-mediated-inflammation
#19
Hong-Liang Chen, Guo-Zhi Dai, An-Wen Zhou, Ran-Hui Li, Hong-Xia Yuan, Jing Xiang, Xiao-Xing You, Ou Ran, Yi-Mou Wu
BACKGROUND: Chlamydia pneumoniae (C. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. However, the molecular signals linking C. pneumoniae components to inflammation remain elusive. This study was to investigate the effect of Chlamydia-specific Cpn0423 of C. pneumoniae on C. pneumoniae-mediated inflammation. RESULTS: Cpn0423 was detected outside of C. pneumoniae inclusions, which induced production of several cytokines including macrophage inflammatory protein-2 (MIP-2) and interleukins (ILs)...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28689699/robust-control-of-post-stall-pitching-maneuver-based-on-finite-time-observer
#20
Dawei Wu, Mou Chen, Huajun Gong
This article presents a robust finite-time maneuver control scheme for the longitudinal attitude dynamic of the aircraft with unsteady aerodynamic disturbances and input saturation. To efficiently eliminate the influence of unsteady aerodynamic disturbances, nonlinear finite-time observers are developed. Despite the existence of the nonlinearity and the coupling between aircraft states and unsteady aerodynamic disturbances, the proposed observers can still precisely estimate the unmeasurable unsteady aerodynamic disturbances in finite time...
July 6, 2017: ISA Transactions
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