Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann, Danielle Westhoff Smith, Larissa B Thackray, Qing Tan, Amy C Sims, Vineet D Menachery, Alexandra Schäfer, Timothy P Sheahan, Adam S Cockrell, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Jennifer E Kyle, Kristin E Burnum-Johnson, Young-Mo Kim, Carrie D Nicora, Zuleyma Peralta, Alhaji U N'jai, Foday Sahr, Harm van Bakel, Michael S Diamond, Ralph S Baric, Thomas O Metz, Richard D Smith, Yoshihiro Kawaoka, Katrina M Waters
Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host model systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses...
April 2, 2024: Scientific Data