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Amir S Steinberg, Anish B Parikh, Sara Kim, Damaris Peralta-Hernandez, Talaat Aggour, Luis Isola
OBJECTIVES: Antibiotic stewardship is an integral aspect of hospital care, limiting the potential for resistance while working to minimize waste. A similar system is needed in oncology, given the rapid proliferation of new therapies and the challenges of navigating a complicated reimbursement environment. A "cancer therapy stewardship program" has never been described in the literature. Here, we detail our efforts to design and implement such a program and share lessons learned to inform future projects...
March 2018: American Journal of Managed Care
Ángela Grillo Pizarro, Eduardo Achú Peralta, María Teresa Muñoz-Quezada, Boris Lucero Mondaca
OBJECTIVE: Organophosphate pesticides (OP) are used massively for their low cost and for their low environmental persistence and their high effectiveness in insect pest control, however, agricultural workers, when exposed to OP, have negative consequences on their health mainly neurological. For the first time, a research is reported in a Latin American population that studied the association between labor exposure to OP and the presence of peripheral polyneuropathy in agricultural workers...
March 22, 2018: Revista Española de Salud Pública
Hernan Garcia-Ruiz, Sergio M Gabriel Peralta, Patricia A Harte-Maxwell
Plant viruses are inducers and targets of antiviral RNA silencing. To condition susceptibility, most plant viruses encode silencing suppressor proteins that interfere with antiviral RNA silencing. The NSs protein is an RNA silencing suppressor in orthotospoviruses, such as the tomato spotted wilt virus (TSWV). The mechanism of RNA silencing suppression by NSs and its role in virus infection and movement are poorly understood. Here, we cloned and tagged TSWV NSs and expressed it from a GFP-tagged turnip mosaic virus (TuMV-GFP) carrying either a wild-type or suppressor-deficient (AS9) helper component proteinase (HC-Pro)...
March 14, 2018: Viruses
Peter Ofman, Peter Hoffmeister, Danny G Kaloupek, David R Gagnon, Adelqui Peralta, Luc Djousse, J Michael Gaziano, Catherine R Rahilly-Tierney
BACKGROUND: The association between posttraumatic stress disorder (PTSD) and mortality in patients undergoing implantable cardioverter defibrillator (ICD) placement has not been evaluated in US veterans. METHODS AND RESULTS: Retrospective cohort of 25,678 veterans who underwent ICD implant between September 30, 2002 and December 31, 2011. 3,280 of these subjects carried the diagnosis of PTSD prior to ICD implant. Primary outcome was mortality from any cause between the date of ICD implant and the end of follow-up, which was September 30, 2013...
March 13, 2018: Clinical Cardiology
Miguel Peralta, João Martins, Dartagnan Pinto Guedes, Hugo Sarmento, Adilson Marques
From a public health perspective, identifying factors related to attaining the physical activity (PA) recommendations is important in order to identify subgroups for intervention programs. The aim of this study is to identify the socio-demographic correlates of attaining the recommended levels of PA in the older European population. Using data from the European Social Survey round 6, PA and socio-demographic characteristics were collected from 10,148 participants (4556 men, 5592 women), aged 65 years and over, from 28 countries in 2012...
March 2018: European Journal of Ageing
Unzue Leire, García Eulogio, Rodríguez Rodrigo Francisco José, Parra Jiménez Francisco Javier, Medina Peralta Juan, Díaz-Antón Belen, Rodríguez Del Río Miguel, Fontenla Adolfo, Teijeiro Rodrigo, Rubio-Alonso Belén
OBJECTIVES: The aim of this study is to describe electrocardiographic changes and conduction abnormalities in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS: 76 patients who underwent TAVI using Edwards Sapien 3 prosthesis were included, comparing electrocardiographic registries at admission, post-procedure and before discharge. RESULTS: Patients after TAVI presented a longer PR interval, a wider QRS, and a longer corrected QT, with a left deviation of QRS axis and T waves; reversible changes that tended to correct in the following days after TAVI...
February 20, 2018: Journal of Electrocardiology
Zhala Meran, Alexandros Besinis, Tracy De Peralta, Richard D Handy
Patients with facial prostheses suffer from yeast, Candida albicans, infections. This study aimed to determine the biocompatibility and antifungal properties of silicone facial prostheses coated with silver nanoparticles (Ag NPs) in vitro. Medical grade silicone discs were coated with 5 and 50 mg L-1 dispersions of either Ag NPs or AgNO3 . Coatings were fully characterized using scanning electron microscopy and energy dispersive X-ray spectroscopy. The biocompatibility was examined using human dermal fibroblasts (Hs68), whereas antifungal efficacy was tested against C...
April 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Eugene Wickett, André Peralta-Santos, Jason Beste, Mary Micikas, Foriest Toe, Julia Rogers, Lassana Jabateh, Bradley H Wagenaar
OBJECTIVES: In June 2015, Partners in Health (PIH) and the Liberian Ministry of Health began a community health worker (CHW) program containing food support, reimbursement of transport and social assistance to address gaps in tuberculosis (TB) treatment exacerbated by the 2014-2015 Ebola-virus disease (EVD) epidemic. The purpose of this article is to analyze the performance of routine clinical TB care and the effects of this CHW program. METHODS: Retrospective cohort study utilizing data from TB patient registers at a census of all health facilities treating TB in southeastern Liberia from January 2015 - April 2017...
March 9, 2018: Tropical Medicine & International Health: TM & IH
Carlos H Trasviña-Arenas, Noe Baruch-Torres, Francisco J Cordoba-Andrade, Víctor M Ayala-García, Paola L García-Medel, Corina Díaz-Quezada, Antolín Peralta-Castro, José Juan Ordaz-Ortiz, Luis G Brieba
Plant mitochondrial and chloroplast genomes encode essential proteins for oxidative phosphorylation and photosynthesis. For proper cellular function, plant organelles must ensure genome integrity. Although plant organelles repair damaged DNA using the multi-enzyme Base Excision Repair (BER) pathway, the details of this pathway in plant organelles are largely unknown. The initial enzymatic steps in BER produce a 5'-deoxyribose phosphate (5'-dRP) moiety that must be removed to allow DNA ligation and in plant organelles, the enzymes responsible for the removal of a 5'-dRP group are unknown...
February 27, 2018: DNA Repair
Carolina Valença Barbosa, Magali Muniz Barreto, Rosemary de Jesus Andrade, Fernando Sodré, Claudia Masini d'Avila-Levy, José Mauro Peralta, Ricardo Pereira Igreja, Heloisa Werneck de Macedo, Helena Lucia Carneiro Santos
BACKGROUND: Intestinal parasitic infections are considered a serious public health problem and widely distributed worldwide, mainly in urban and rural environments of tropical and subtropical countries. Globally, soil-transmitted helminths and protozoa are the most common intestinal parasites. Blastocystis sp. is a highly prevalent suspected pathogenic protozoan, and considered an unusual protist due to its significant genetic diversity and host plasticity. METHODOLOGY/MAIN FINDINGS: A total of 294 stool samples were collected from inhabitants of three rural valleys in Rio de Janeiro, Brazil...
2018: PloS One
Francisca Pérez-Ramírez, Inmaculada García-García, Rafael A Caparros-Gonzalez, María Isabel Peralta-Ramírez
OBJECTIVE: to describe whether there were differences in sociodemographic, obstetric, perinatal and psychological variables between immigrant women and native-born women in Spain during the first 24 h after delivery. BACKGROUND: The immediate postpartum period is a critical time when physical and psychological disorders are likely to occur. Immigrant women have, in general, poor perinatal and psychological results during this time. METHODS: One hundred and three women at the Virgen de las Nieves University Hospital (Granada, Spain) were divided into two groups: 50 Spanish and 53 immigrants...
April 2017: Journal of Reproductive and Infant Psychology
Anny Peralta-García, Andrea J Adams, Cheryl J Briggs, Patricia Galina-Tessaro, Jorge H Valdez-Villavicencio, Bradford D Hollingsworth, H Bradley Shaffer, Robert N Fisher
Chytridiomycosis is caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd) and is regarded as one of the most significant threats to global amphibian populations. In México, Bd was first reported in 2003 and has now been documented in 13 states. We visited 33 localities and swabbed 199 wild-caught anurans from 7 species (5 native, 2 exotic) across the Mediterranean region of the state of Baja California. Using quantitative PCR, Bd was detected in 94 individuals (47.2% of samples) at 25 of the 33 survey localities for 5 native and 1 exotic frog species...
March 5, 2018: Diseases of Aquatic Organisms
Elaine Ku, Eric Vittinghoff, David R Jacobs, Cora E Lewis, Norrina B Allen, Kirsten Bibbins-Domingo, Michael Shlipak, Holly Kramer, Carmen A Peralta
BACKGROUND: Many studies have focused on the association between a single blood pressure (BP) measurement and risk for adverse outcomes. However, the association of BP trajectories during young adulthood with subsequent decline in kidney function has not been well defined. STUDY DESIGN: Observational cohort study. SETTING & PARTICIPANTS: 3,429 participants in the Coronary Artery Risk Development in Young Adulthood (CARDIA) Study enrolled between the ages of 18 and 30 years...
March 3, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jaime F Perez, Ana María Díaz B, Gustavo U Ramos, Sara R Peralta
Congenital posterior urethral-perineal fistula is an abnormal communication extending from the posterior urethra to the perineal skin. We present the case of an 11-year-old boy who had recurrent febrile urinary tract infections and abnormal dribbling of urine from the perineum. Fistulogram showed a paraescrotal fistula tract, which was then surgically excised. During the 10 months of follow-up, the patient remained asymptomatic without recurrence of urinary pathology.
March 6, 2018: Urologia Internationalis
Juan Girbés Borrás, Javier Escalada San Martín, Manel Mata Cases, Fernando Gomez-Peralta, Sara Artola Menéndez, Diego Fernández García, Carlos Ortega Millán, Fernando Alvarez Guisasola, Juan Carlos Ferrer García, Patxi Ezkurra Loiola, Fernando Escobar Jiménez, José Antonio Fornos Pérez, Mercedes Galindo Rubio, Itxaso Rica Echevarría, Edelmiro Menéndez Torre
No abstract text is available yet for this article.
March 1, 2018: Endocrinología, Diabetes y Nutrición
Gonzalo Farias, Ernesto Fabregas, Emmanuel Peralta, Héctor Vargas, Gabriel Hermosilla, Gonzalo Garcia, Sebastián Dormido
Proximity sensors are broadly used in mobile robots for obstacle detection. The traditional calibration process of this kind of sensor could be a time-consuming task because it is usually done by identification in a manual and repetitive way. The resulting obstacles detection models are usually nonlinear functions that can be different for each proximity sensor attached to the robot. In addition, the model is highly dependent on the type of sensor (e.g., ultrasonic or infrared), on changes in light intensity, and on the properties of the obstacle such as shape, colour, and surface texture, among others...
February 25, 2018: Sensors
Fernando G Dupuy, Isabella Pagano, Kathryn Andenoro, Maria F Peralta, Yasmene Elhady, Frank Heinrich, Stephanie Tristram-Nagle
Although colistin's clinical use is limited due to its nephrotoxicity, colistin is considered to be an antibiotic of last resort because it is used to treat patients infected with multidrug-resistant bacteria. In an effort to provide molecular details about colistin's ability to kill Gram-negative (G(-)) but not Gram-positive (G(+)) bacteria, we investigated the biophysics of the interaction between colistin and lipid mixtures mimicking the cytoplasmic membrane of G(+), G(-) bacteria as well as eukaryotic cells...
February 27, 2018: Biophysical Journal
Carlos Flores, Erika González, Andrea Verna, Andrea Peralta, Carolina Madariaga, Anselmo Odeón, Germán Cantón
Infection with the orf virus, also known as contagious ecthyma, is recognized as an occupational zoonosis worldwide. It is diagnosed by cutaneous lesions that progress rapidly from macules to papules, vesicles and pustules. The clinical case of a student of veterinary medicine who had had contact with goats, clinically healthy and without apparent lesions, which occured 19 days ago, is reported. She presented two vesicular lesions that coalesced to form a larger lesion surrounded by an erythematous halo. The lesions were compatible with the classical presentation of those produced by the orf virus in humans...
December 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Rúbia C G Corrêa, Lillian Barros, Ângela Fernandes, Marina Sokovic, Adelar Bracht, Rosane M Peralta, Isabel C F R Ferreira
In recent years, mycosterols have emerged as potential functional ingredients for the development of sterol-enriched food products and dietary supplements. Agaricus blazei is a mushroom rich in bioactive compounds. For commercial purposes, their fruiting bodies must obey rigid morphological criteria. Those not conforming to these criteria are usually discarded, although this does not mean impairment of their content in bioactives. The aim of the present work was to propose the use of commercially discarded A...
February 28, 2018: Food & Function
Mariana Andrea Peralta, María Gabriela Ortega, José Luis Cabrera, María Gabriela Paraje
The antioxidant effect of 8PP, a prenylflavonoid from Dalea elegans on Candida albicans biofilms, was investigated. We previously reported that sensitive (SCa) and resistant C. albicans (RCa) biofilms were strongly inhibited by this compound, in a dose-depending manner (50 μM-100 μM), with a prooxidant effect leading to accumulation of endogenous oxidative metabolites and increased antioxidant defenses. In this work, the antifungal activity of high concentrations of 8PP (200-1000 μM), the cellular stress imbalance and the architecture of biofilms were evaluated...
February 21, 2018: Food and Chemical Toxicology
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