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https://www.readbyqxmd.com/read/29340156/hepatotoxicity-in-hyperthyroid-patient-after-consecutive-methimazole-and-propylthiouracil-therapies
#1
Fernando Gomez-Peralta, Pablo Velasco-Martínez, Cristina Abreu, María Cepeda, Marta Fernández-Puente
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history diagnosed with hyperthyroidism due to Graves' disease, who developed two episodes of acute hepatitis concurrent with the consecutive administration of two different ATDs, first MMI and then PTU...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29335809/healthcare-and-social-services-providers-who-serve-sexual-and-gender-minorities-in-a-u-s-mexico-border-city
#2
Oralia Loza, Carlos R Alvarez, David Peralta-Torres
Sexual and gender minorities, including lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals, experience barriers to healthcare as a result of stigma, discrimination, and poor cultural competence by healthcare and social services providers (HCSSP). The purpose of the study is to increase access to care and services for the LGBTQ community in a U.S.-Mexico border city by identifying LGBTQ-friendly HCSSP. A survey, developed based on concerns voiced in a predominantly Hispanic LGBTQ community, was administered to HCSSP and used to create a referral list, "The Purple Pages of El Paso" (PPoEP)...
January 15, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29335795/combined-effects-of-predator-cues-and-competition-define-habitat-choice-and-food-consumption-of-amphipod-mesograzers
#3
Jan Beermann, Karin Boos, Lars Gutow, Maarten Boersma, Ana Carolina Peralta
Predation has direct impact on prey populations by reducing prey abundance. In addition, predator presence alone can also have non-consumptive effects on prey species, potentially influencing their interspecific interactions and thus the structure of entire assemblages. The performance of potential prey species may, therefore, depend on both the presence of predators and competitors. We studied habitat use and food consumption of a marine mesograzer, the amphipod Echinogammarus marinus, in the presence/absence of a fish mesopredator and/or an amphipod competitor...
January 15, 2018: Oecologia
https://www.readbyqxmd.com/read/29332150/ectoparasite-activity-during-incubation-increases-microbial-growth-on-avian-eggs
#4
G Tomás, D Martín-Gálvez, C Ruiz-Castellano, M Ruiz-Rodríguez, J M Peralta-Sánchez, M Martín-Vivaldi, J J Soler
While direct detrimental effects of parasites on hosts are relatively well documented, other more subtle but potentially important effects of parasitism are yet unexplored. Biological activity of ectoparasites, apart from skin injuries and blood-feeding, often results in blood remains, or parasite faeces that accumulate and modify the host environment. In this way, ectoparasite activities and remains may increase nutrient availability that may favour colonization and growth of microorganisms including potential pathogens...
January 13, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29331809/environmental-behavior-of-coated-nms-physicochemical-aspects-and-plant-interactions
#5
REVIEW
Martha L López-Moreno, Yarilyn Cedeño-Mattei, Sonia Janet Bailón-Ruiz, Edgar Vazquez-Nuñez, José A Hernandez-Viezcas, Oscar Juan Perales-Pérez, Guadalupe De la Rosa, José R Peralta-Videa, Jorge L Gardea-Torresdey
The application of nanomaterials (NMs) depends on several characteristics, including polydispersity, shape, surface charge, and composition, among others. However, the specific surface properties of bare NMs induce aggregation, reducing their utilization. Thus, different surface coverages have been developed to avoid or minimize NMs aggregation, making them more stable for the envisioned applications. Carbon-based NMs are usually coated with metals, while metal-based NMs are coated with natural organic compounds including chitosan, dextran, alginate, or citric acid...
December 25, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29323410/housing-first-and-photovoice-transforming-lives-communities-and-systems
#6
Anna S Pruitt, John P Barile, Terry Yasuko Ogawa, Nelson Peralta, Reumell Bugg, John Lau, Thomas Lamberton, Corazon Hall, Victor Mori
This article presents findings from a community-based participatory evaluation of a Housing First program on the Island of O'ahu. In this study, clients in a Housing First program used Photovoice to evaluate the program and to advocate for progressive housing policies. Written together by members of the Housing First Photovoice group, this collaborative article describes the outcomes from both the Housing First program and the Photovoice project and demonstrates the ways in which participatory program evaluations can interact with client-driven programs like Housing First to produce a cumulative, transformative impact...
January 11, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29314769/diversity-in-medicinal-chemistry
#7
EDITORIAL
David Peralta
The wide world of medicinal chemistry: We look back at our activities in 2017, particularly the expansion of the journal's scope to nanomedicine and why we need a more inclusive medicinal chemistry journal. Additionally, we look at upcoming special issues and developments for ChemPubSoc Europe in 2018.
January 8, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29309300/reappraisal-of-morphologic-differences-between-renal-medullary-carcinoma-collecting-duct-carcinoma-and-fumarate-hydratase-deficient-renal-cell-carcinoma
#8
Chisato Ohe, Steven C Smith, Deepika Sirohi, Mukul Divatia, Mariza de Peralta-Venturina, Gladell P Paner, Abbas Agaimy, Mitual B Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Maurizio Colecchia, Eva Compérat, Isabela Werneck da Cunha, Jonathan I Epstein, Anthony J Gill, Ondřej Hes, Michelle S Hirsch, Wolfram Jochum, Lakshmi P Kunju, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K McKenney, Rohit Mehra, Gabriella Nesi, Adeboye O Osunkoya, Maria M Picken, Priya Rao, Victor E Reuter, Paulo Guilherme de Oliveira Salles, Luciana Schultz, Satish K Tickoo, Scott A Tomlins, Kiril Trpkov, Mahul B Amin
Renal medullary carcinomas (RMCs) and collecting duct carcinomas (CDCs) are rare subsets of lethal high-stage, high-grade distal nephron-related adenocarcinomas with a predilection for the renal medullary region. Recent findings have established an emerging group of fumarate hydratase (FH)-deficient tumors related to hereditary leiomyomatosis and renal cell carcinoma (HLRCC-RCCs) syndrome within this morphologic spectrum. Recently developed, reliable ancillary testing has enabled consistent separation between these tumor types...
January 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29308737/did-prasugrel-and-ticagrelor-offer-the-same-benefit-in-patients-with-acute-coronary-syndromes-after-percutaneous-coronary-interventions-compared-to-clopidogrel-insights-from-randomized-clinical-trials-registries-and-meta-analysis
#9
Alfredo E Rodriguez, Alfredo M Rodriguez-Granillo, Sergio D Ascarrunz, Francisco Peralta-Bazan, Mi Young Cho
BACKGROUND: According to ACC/ AHA guidelines, a minimum of 1 year of dual anti- platelet therapy (DAPT) consisting of aspirin and a platelet ADP-receptor antagonist (P2Y12 inhibitor) is recommended for patients presenting acute coronary syndromes (ACS), regardless of which type of revascularization is performed during the acute event. METHODS: The purpose of this presentation was to review the present data either from a direct randomized comparison among the three compounds and also large prospective observational registries and meta-analysis were analyzed in detail...
January 8, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29305053/structure-kinetics-molecular-and-redox-properties-of-a-cytosolic-and-developmentally-regulated-fungal-catalase-peroxidase
#10
Vanessa Vega-García, Adelaida Díaz-Vilchis, Juan-Pablo Saucedo-Vázquez, Alejandro Solano-Peralta, Enrique Rudiño-Piñera, Wilhelm Hansberg
CAT-2, a cytosolic catalase-peroxidase (CP) from Neurospora crassa, which is induced during asexual spore formation, was heterologously expressed and characterized. CAT-2 had the Met-Tyr-Trp adduct required for catalase activity. Its KM for H2O2 was micromolar for peroxidase and millimolar for catalase activity. A Em = -158 mV reduction potential value was obtained and the Soret band shift suggested a mixture of low and high spin ferric iron. CAT-2 EPR spectrum at 10 K indicated an axial and a rhombic component...
January 2, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29294803/are-polydrug-users-more-physically-and-verbally-aggressive-an-assessment-of-aggression-among-mono-versus-polydrug-users-in-a-university-sample
#11
Jennifer L Steele, Robert L Peralta
Early research has revealed that patterns of aggression and antisocial behavior are present among polydrug users. Often missing from this discourse is the examination of whether polydrug users are quantitatively different from monodrug users in their use of aggression. Theoretical perspectives are often centered on the psychopharmacological effects of substance use on behavior. Consideration of possible poly- versus monodrug use differences and their impact on aggression has not been investigated. Data from this study were derived from a sample of Midwestern university students ( N = 793)...
June 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29279374/evaluating-the-contribution-of-rare-variants-to-type-2-diabetes-and-related-traits-using-pedigrees
#12
Goo Jun, Alisa Manning, Marcio Almeida, Matthew Zawistowski, Andrew R Wood, Tanya M Teslovich, Christian Fuchsberger, Shuang Feng, Pablo Cingolani, Kyle J Gaulton, Thomas Dyer, Thomas W Blackwell, Han Chen, Peter S Chines, Sungkyoung Choi, Claire Churchhouse, Pierre Fontanillas, Ryan King, SungYoung Lee, Stephen E Lincoln, Vasily Trubetskoy, Mark DePristo, Tasha Fingerlin, Robert Grossman, Jason Grundstad, Alison Heath, Jayoun Kim, Young Jin Kim, Jason Laramie, Jaehoon Lee, Heng Li, Xuanyao Liu, Oren Livne, Adam E Locke, Julian Maller, Alexander Mazur, Andrew P Morris, Toni I Pollin, Derek Ragona, David Reich, Manuel A Rivas, Laura J Scott, Xueling Sim, Rick G Tearle, Yik Ying Teo, Amy L Williams, Sebastian Zöllner, Joanne E Curran, Juan Peralta, Beena Akolkar, Graeme I Bell, Noël P Burtt, Nancy J Cox, Jose C Florez, Craig L Hanis, Catherine McKeon, Karen L Mohlke, Mark Seielstad, James G Wilson, Gil Atzmon, Jennifer E Below, Josée Dupuis, Dan L Nicolae, Donna Lehman, Taesung Park, Sungho Won, Robert Sladek, David Altshuler, Mark I McCarthy, Ravindranath Duggirala, Michael Boehnke, Timothy M Frayling, Gonçalo R Abecasis, John Blangero
A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare variants to the risk of type 2 diabetes (T2D) and related traits, we performed deep whole-genome analysis of 1,034 members of 20 large Mexican-American families with high prevalence of T2D. If rare variants of large effect accounted for much of the diabetes risk in these families, our experiment was powered to detect association...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29277719/miniature-pig-model-of-human-adolescent-brain-white-matter-development
#13
Meghann C Ryan, Paul Sherman, Laura M Rowland, S Andrea Wijtenburg, Ashley Acheson, Els Fieremans, Jelle Veraart, Dmitry Novikov, L Elliot Hong, John Sladky, P Dana Peralta, Peter Kochunov, Stephen A McGuire
BACKGROUND: Neuroscience research in brain development and disorders can benefit from an in vivo animal model that portrays normal white matter (WM) development trajectories and has a sufficiently large cerebrum for imaging with human MRI scanners and protocols. NEW METHOD: Twelve three-month-old Sinclair™ miniature pigs (Sus scrofa domestica) were longitudinally evaluated during adolescent development using advanced diffusion weighted imaging (DWI) focused on cerebral WM...
December 22, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29275423/alcohol-screening-in-a-national-referral-hospital-an-observational-study-from-qatar
#14
Ayman El-Menyar, Rafael Consunji, Ahammed Mekkodathil, Ruben Peralta, Hassan Al-Thani
BACKGROUND Alcohol consumption is a high-risk factor for several medical disorders and traffic accidents and poses a burden on outpatient clinics and emergency units. We aimed to assess the pattern of alcohol screening among patients in a multicultural setting in a national referral hospital in an Arab Middle-Eastern country. MATERIAL AND METHODS A retrospective analysis was conducted for patients who were screened with blood alcohol concentration (BAC) in the Emergency Department (ED) in the period from January 2009 to December 2012...
December 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29273232/the-impact-of-double-source-of-vibration-semioccluded-voice-exercises-on-objective-and-subjective-outcomes-in-subjects-with-voice-complaints
#15
Marco Guzman, Gabriela Acuña, Fernanda Pacheco, Francisca Peralta, Constanza Romero, Cecilia Vergara, Camilo Quezada
PURPOSE: The present study reports the effects of double source of vibration semioccluded vocal tract exercises (SOVTEs) on subjective and objective variables in subjects with voice complaints. METHODS: Eighty-four participants with voice complaints were randomly assigned to one of four treatment groups: (1) water resistance therapy, (2) tongue trills, (3) lip trills, and (4) raspberry (tongue and lip trills at the same time). Before and after voice therapy, participants underwent aerodynamic, electroglottographic, and acoustic assessments...
December 19, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29261536/sleeping-tv-cognitively-stimulating-activities-physical-activity-and-adhd-symptom-incidence-in-children-a-prospective-study
#16
Gabriela P Peralta, Joan Forns, Manuela García de la Hera, Llúcia González, Mònica Guxens, Mónica López-Vicente, Jordi Sunyer, Judith Garcia-Aymerich
OBJECTIVE: To analyze associations between time spent sleeping, watching TV, engaging in cognitively stimulating activities, and engaging in physical activity, all at 4 years, and (1) attention-deficit/hyperactivity disorder (ADHD) symptoms and (2) behavior problems, both assessed at 7 years, in ADHD-free children at baseline. METHOD: In total, 817 participants of the Infancia y Medio Ambiente birth cohort, without ADHD at baseline, were included. At the 4-year follow-up, parents reported the time that their children spent sleeping, watching TV, engaging in cognitively stimulating activities, and engaging in physical activity...
December 18, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29260330/anesthetic-activity-and-the-electrostatic-potential-revisited
#17
Zenaida Peralta-Inga Shields, Paul G Seybold, Jane S Murray
A survey of the fascinating history of anesthetics and the many critical findings that have improved our understanding of anesthetic activity is followed by an expanded analysis of the electrostatic potentials of 27 molecules and two noble gases with anesthetic activities ranging from high to totally inactive. We again find that an intermediate value for the internal charge separation (polarity) Π appears to be an important factor in anesthetic activity. Other electrostatic potential features that favor high anesthetic activity include the presence of at least one strongly positive site on the molecule and regions of weakly to moderately negative electrostatic potential...
December 19, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29251687/implementing-resistance-training-in-secondary-schools-a-cluster-randomized-controlled-trial
#18
Sarah G Kennedy, Jordan J Smith, Philip J Morgan, Louisa R Peralta, Toni A Hilland, Narelle Eather, Chris Lonsdale, Anthony D Okely, Ronald C Plotnikoff, J O Salmon, Deborah L Dewar, Paul A Estabrooks, Emma Pollock, Tara L Finn, David R Lubans
PURPOSE: Guidelines recommend that young people engage in muscle-strengthening activities on at least 3 d·wk. The purpose of this study was to examine the effect of a school-based intervention focused on resistance training (RT) for adolescents. METHODS: The "Resistance Training for Teens" intervention was evaluated using a cluster-randomized, controlled trial with 607 adolescents (50.1% girls; 14.1 ± 0.5 yr) from 16 secondary schools. Teachers were trained to deliver the intervention, which included the following: (i) an interactive student seminar; (ii) a structured physical activity program, focused on RT; (iii) lunchtime fitness sessions; and (iv) Web-based smartphone apps...
January 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29248952/a-comprehensive-care-program-achieves-high-remission-rates-in-rheumatoid-arthritis-in-a-middle-income-setting-experience-of-a-center-of-excellence-in-colombia
#19
Pedro Santos-Moreno, Nelson J Alvis-Zakzuk, Laura Villarreal-Peralta, Maria Carrasquilla-Sotomayor, Angel Paternina-Caicedo, Nelson Alvis-Guzmán
Management of rheumatoid arthritis (RA) in many Latin-American countries is impaired by fragmentation and scarce healthcare provision, resulting in obstacles to access, diagnosis, and treatment, and consequently in poor health outcomes. The aim of this study is to propose a comprehensive care program as a model to provide healthcare to RA patients receiving synthetic DMARDs in a Colombian setting by describing the model and its results. Health outcomes were prospectively collected in all patients entering the program...
December 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29235857/second-sphere-effects-in-dinuclear-feiiiznii-hydrolase-biomimetics-tuning-binding-and-reactivity-properties
#20
Tiago Pacheco Camargo, Ademir Neves, Rosely A Peralta, Cláudia Chaves, Elene C P Maia, Edgar H Lizarazo-Jaimes, Dawidson A Gomes, Tiago Bortolotto, Douglas R Norberto, Hernán Terenzi, David L Tierney, Gerhard Schenk
Herein, we report the synthesis and characterization of two dinuclear FeIIIZnII complexes [FeIIIZnIILP1] (1) and [FeIIIZnIILP2] (2), in which LP1 and LP2 are conjugated systems containing one and two pyrene groups, respectively, connected via the diamine -HN(CH2)4NH- spacer to the well-known N5O2-donor H2L ligand (H2L = 2-bis{[(2-pyridylmethyl)aminomethyl]-6-[(2-hydroxybenzyl)(2-pyridylmethyl)]aminomethyl}-4-methylphenol). The complex [FeIIIZnIIL1] (3), in which H2L was modified to H2L1, with a carbonyl group attached to the terminal phenol group, was included in this study for comparison purposes...
December 13, 2017: Inorganic Chemistry
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