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https://www.readbyqxmd.com/read/28338937/association-of-blood-pressure-trajectory-with-mortality-incident-cardiovascular-disease-and-heart-failure-in-the-cardiovascular-health-study
#1
Christopher C Smitson, Rebecca Scherzer, Michael G Shlipak, Bruce M Psaty, Anne B Newman, Mark J Sarnak, Michelle C Odden, Carmen A Peralta
BACKGROUND: Common blood pressure (BP) trajectories are not well established in elderly persons, and their association with clinical outcomes is uncertain. METHODS: We used hierarchical cluster analysis to identify discrete BP trajectories among 4,067 participants in the Cardiovascular Health Study using repeated BP measures from years 0 to 7. We then evaluated associations of each BP trajectory cluster with all-cause mortality, incident cardiovascular disease (CVD, defined as stroke or myocardial infarction) (N = 2,837), and incident congestive heart failure (HF) (N = 3,633) using Cox proportional hazard models...
March 10, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28338726/cumulative-exposure-to-systolic-blood-pressure-during-young-adulthood-through-midlife-and-the-urine-albumin-to-creatinine-ratio-at-midlife
#2
Holly Kramer, Laura Colangelo, Cora E Lewis, David R Jacobs, Mark Pletcher, Kirstin Bibbins-Domingo, Alex Chang, David Siscovick, Michael Shlipak, Carmen A Peralta, Nisha Bansal, Paul Muntner, Kiang Liu
BACKGROUND: Higher blood pressure during young adulthood may increase cardiovascular and kidney disease risk later in life. This study examined the association of cumulative systolic blood pressure (SBP) exposure during young adulthood through midlife with urine albumin-to-creatinine ratios (ACR) measured during midlife. METHODS: We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a biracial cohort recruited in 4 urban areas during years 1985-1986...
February 21, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28326628/incidence-recurrence-and-cost-of-hyperglycaemic-crises-requiring-emergency-treatment-in-andalusia-spain
#3
R J Barranco, F Gomez-Peralta, C Abreu, M Delgado-Rodriguez, A Moreno-Carazo, F Romero, M A de la Cal, J M Barranco, F J Pasquel, G E Umpierrez
AIMS: Hyperglycaemic crises (diabetic ketoacidosis and hyperosmolar hyperglycaemic state) are medical emergencies in people with diabetes. We aimed to determine their incidence, recurrence and economic impact. METHODS: An observational study of hyperglycaemic crises cases using the database maintained by the out-of-hospital emergency service, the Healthcare Emergency Public Service (EPES) during 2012. The EPES provides emergency medical services to the total population of Andalusia, Spain (8...
March 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28322470/anti-inflammatory-and-antioxidant-actions-of-copaiba-oil-are-related-to-liver-cell-modifications-in-arthritic-rats
#4
Cristiane V de Castro Ghizoni, Ana P Arssufi Ames, Osmar A Lameira, Ciomar A Bersani Amado, Anacharis B de Sá Nakanishi, Lívia Bracht, Maria R Marçal Natali, Rosane M Peralta, Adelar Bracht, Jurandir F Comar
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15 g · Kg(-1) , arthritic rats, and arthritic rats treated with copaiba oil (0...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28320553/kidney-transplantation-for-kidney-failure-due-to-multiple-myeloma-case-reports
#5
Thuy X Le, Jeffrey L Wolf, Carmen A Peralta, Allison B Webber
Transplantation centers have historically considered a history of multiple myeloma as a contraindication to kidney transplantation due to high recurrence rates and poor transplant survival. However, there have been significant advances in the treatment of multiple myeloma, with improved patient survival, which may allow for successful kidney transplantation in these patients. We report on 4 patients who underwent kidney transplantation at our institution between 2009 and 2015 after having achieved a very good partial response or better with chemotherapy and autologous stem cell transplantation...
March 17, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28306145/functional-status-modifies-the-association-of-blood-pressure-with-death-in-elders-health-and-retirement-study
#6
Chenkai Wu, Ellen Smit, Carmen A Peralta, Harini Sarathy, Michelle C Odden
OBJECTIVE: To examine whether grip strength, gait speed, and the combination of the two physical functioning measures modified the association of systolic BP (SBP) and diastolic BP (DBP) with mortality. DESIGN: Nationally representative cohort study. SETTING: Health and Retirement Study. PARTICIPANTS: 7,492 U.S. adults aged ≥65 years. MEASUREMENTS: Grip strength was measured by a hand dynamometer and classified as normal (≥16 kg for female; ≥26 kg for male) and weak...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28304154/nanostructured-thermal-responsive-materials-synthesized-by-soft-templating
#7
Cedric Vancaeyzeele, Florian Olivier, Gwendoline Petroffe, Sebastien Peralta, Frederic Vidal
We capitalized herein the inherent tortuosity of bicontinuous microemulsion to conceive nanostructured drug delivery devices. First, we show that it is possible to synthesize bicontinuous materials with continuous hydrophilic domains of PNIPAM network entangled with continuous hydrophobic polymer domains, dual phase continuity being imposed by the bicontinuous microemulsions used as soft template. A particular attention is paid to the microemulsion formulations using a surfmer to preserve the one-to-one replication of the bicontinuous nanostructure after polymerization...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28296374/-protocol-for-the-care-of-acute-myocardial-infarction-in-emergency-c%C3%A3-digo-infarto-the-infarction-code
#8
Gabriela Borrayo-Sánchez, Gilberto Pérez-Rodríguez, Olga Georgina Martínez-Montañez, Eduardo Almeida-Gutiérrez, Erick Ramírez-Arias, Joel Estrada-Gallegos, Norma Magdalena Palacios-Jiménez, Martín Rosas-Peralta, Efraín Arizmendi-Uribe, Jesús Arriaga-Dávila
Cardiovascular diseases are a major public health problem because of their they impact on more than 30% of all deaths worldwide. In our country and in the Instituto Mexicano del Seguro Social (IMSS) are also the leading cause of death and the main cause of lost of healthy life years due to disability or premature death. 50% of deaths are premature; most of them are due to acute myocardial infarct. However, the investment for cardiovascular health is poor and there are no comprehensive cares programs focused on the treatment of this diseases or the control of their risk factors...
March 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28294686/utility-of-combining-whole-genome-sequencing-with-traditional-investigational-methods-to-solve-foodborne-outbreaks-of-salmonella-infections-associated-with-chicken-a-new-tool-for-tackling-this-challenging-food-vehicle
#9
Samuel J Crowe, Alice Green, Kimberly Hernandez, Vi Peralta, Lyndsay Bottichio, Stephanie Defibaugh-Chavez, Aphrodite Douris, Laura Gieraltowski, Kelley Hise, Karen La-Pham, Karen P Neil, Mustafa Simmons, Glenn Tillman, Beth Tolar, Darlene Wagner, Jamie Wasilenko, Kristin Holt, Eija Trees, Matthew E Wise
High consumption rates and a multitude of brands make multistate foodborne outbreaks of Salmonella infections associated with chicken challenging to investigate, but whole genome sequencing is a powerful tool that can be used to assist investigators. Whole genome sequencing of pathogens isolated from clinical, environmental, and food samples is increasingly being used in multistate foodborne outbreak investigations to determine with unprecedented resolution how closely related these isolates are to one another genetically...
March 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28280138/sickle-cell-trait-and-the-risk-of-esrd-in-blacks
#10
Rakhi P Naik, Marguerite R Irvin, Suzanne Judd, Orlando M Gutiérrez, Neil A Zakai, Vimal K Derebail, Carmen Peralta, Michael R Lewis, Degui Zhi, Donna Arnett, William McClellan, James G Wilson, Alexander P Reiner, Jeffrey B Kopp, Cheryl A Winkler, Mary Cushman
Blacks, compared with whites, have an increased risk of progression to end-stage renal disease (ESRD). Emerging evidence suggests that, in addition to APOL1 high-risk genotypes, hemoglobin variants, including sickle cell trait (SCT) and hemoglobin C trait, have a role in kidney disease in blacks. However, the association between these hemoglobin traits and ESRD remains unknown. In a large population-based cohort, the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, we evaluated 9909 self-reported blacks (739 with SCT and 243 with hemoglobin C trait)...
March 9, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28279117/progression-of-doppler-changes-in-early-onset-small-for-gestational-age-fetuses-how-frequent-are-the-different-progression-sequences
#11
José Morales-Roselló, Asma Khalil, Victoria Fornés-Ferrer, José Alberola-Rubio, David Hervas-Marín, Núria Peralta Llorens, Alfredo Perales-Marín
OBJECTIVE: To evaluate the progression of Doppler abnormalities in early-onset fetal smallness (SGA). METHODS: 948 Doppler examinations of the umbilical artery (UA), middle cerebral artery (MCA) and ductus venosus (DV), belonging to 405 early-onset SGA fetuses, were studied, evaluating the sequences of Doppler progression, the interval examination-labor at which Doppler became abnormal and the cumulative sum of Doppler anomalies in relation with labor proximity...
March 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28273219/evaluation-of-care-for-traffic-accidents-victims-made-by-on-duty-emergency-physicians-and-surgeons-in-the-emergency-room
#12
Vlaudimir Dias Marques, Mauricio Medeiros Lemos, Cesar Orlando Peralta Bandeira, Amélia Cristina Seidel, Sandra Maria Peloso, Maria Dalva DE Barros Carvalho
OBJECTIVE: to evaluate the care for victims of traffic accidents by on call emergency physicians and/or surgeons in the emergency room. METHODS: we conducted a retrospective, descriptive and exploratory study on the care for traffic accidents victims in the urban area of ​​Maringá-PR, between July 2013 and July 2014 in reference hospitals. We assessed demographics and vocational training through a questionnaire sent to the attending physicians. RESULTS: of the 688 records evaluated, 99% of patients had a prehospital Revised Trauma Score of 12...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28273086/two-new-ootaxa-from-the-late-jurassic-the-oldest-record-of-crocodylomorph-eggs-from-the-lourinh%C3%A3-formation-portugal
#13
João Russo, Octávio Mateus, Marco Marzola, Ausenda Balbino
The Late Jurassic Lourinhã Formation is known for its abundant remains of dinosaurs, crocodylomorphs and other vertebrates. Among this record are nine localities that have produced either dinosaur embryos, eggs or eggshell fragments. Herein, we describe and identify the first crocodiloid morphotype eggs and eggshells from the Lourinhã Formation, from five occurrences. One clutch from Cambelas, composed of 13 eggs, eggshell fragments from Casal da Rola and Peralta, one crushed egg and eggshells from Paimogo North, and four crushed eggs as well as eggshell fragments from Paimogo South...
2017: PloS One
https://www.readbyqxmd.com/read/28272770/sex-differences-in-vascular-dysfunction-and-cardiovascular-outcomes-the-cardiac-endothelial-function-and-arterial-stiffness-in-esrd-ceres-study
#14
Isabella Guajardo, Amrita Ayer, Alexander D Johnson, Peter Ganz, Claire Mills, Catherine Donovan, Rebecca Scherzer, Sanjiv J Shah, Carmen A Peralta, Ruth F Dubin
INTRODUCTION: Recent studies suggest that women with end-stage renal disease (ESRD) may have higher rates of mortality than men, but it is unknown whether sex differences in vascular function explain this disparity. The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study is an ongoing, prospective observational study designed to investigate vascular function, myocardial injury, and cardiovascular outcomes in ESRD. METHODS: Among 200 CERES participants (34% women), we evaluated arterial wave reflections as augmentation index normalized to a heart rate of 75 (AIx75), arterial stiffness as pulse wave velocity, and macro- and microvascular endothelial dysfunction as flow-mediated dilation and velocity time integral (VTI)...
March 8, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28271068/corrigendum-to-t-helper-17-regulatory-t-cell-balance-and-experimental-models-of-peritoneal-dialysis-induced-damage
#15
Georgios Liappas, Guadalupe Tirma Gónzalez-Mateo, Pedro Majano, José Antonio Sánchez-Tomero, Marta Ruiz-Ortega, Raquel Rodrigues Díez, Pilar Martín, Raquel Sanchez-Díaz, Rafael Selgas, Manuel López-Cabrera, Abelardo Aguilera Peralta
[This corrects the article DOI: 10.1155/2015/416480.].
2017: BioMed Research International
https://www.readbyqxmd.com/read/28268138/chemical-and-bioactivity-of-flavanones-obtained-from-roots-of-dalea-pazensis-rusby
#16
María D Santi, Mariana A Peralta, Caterine S Mendoza, José Luis Cabrera, María G Ortega
Two new prenylated flavanones, pazentin A (3',4'-dihydroxy-6,2'-diprenylpinocembrin, 1) and pazentin B [4'-hydroxy-2'-methoxy-5'-(1‴, 1‴-dimethylallyl)-6-prenylpinocembrin, 2] together with two known ones (3 and 4) previously isolated from other Dalea species were obtained from the benzene extract of Dalea pazensis Rusby roots. The compounds were evaluated in vitro for their inhibition on mushroom tyrosinase enzyme and in relation to their effect on melanogenesis in B16 murine melanoma cells, by using a spectrophotometric method...
February 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28267443/balloon-removal-after-fetoscopic-endoluminal-tracheal-occlusion-for-congenital-diaphragmatic-hernia
#17
Julio A Jiménez, Elisenda Eixarch, Philip Dekoninck, João R Bennini, Roland Devlieger, Cleisson F Peralta, Eduard Gratacos, Jan Deprest
BACKGROUND: Isolated congenital diaphragmatic hernia (CDH) defect allows viscera to herniate into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. Antenatal measurement of lung size and liver herniation can predict survival after birth. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28267409/myogenic-differentiation-potential-of-mesenchymal-stem-cells-derived-from-fetal-bovine-bone-marrow
#18
Lucas Hidenori Okamura, Paloma Cordero, Jaime Palomino, Victor Hugo Parraguez, Cristian Gabriel Torres, Oscar Alejandro Peralta
The myogenic potential of bovine fetal MSC (bfMSC) derived from bone marrow (BM) remains unknown; despite its potential application for the study of myogenesis and its implications for livestock production. In the present study, three protocols for in vitro myogenic differentiation of bfMSC based on the use of DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza), myoblast-secreted factor Galectin-1 (Gal-1), and myoblast culture medium SkGM-2 BulletKit were used. Plastic-adherent bfMSC were isolated from fetal BM collected from abattoir-derived fetuses...
March 7, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28263118/a-model-curriculum-for-the-study-of-animal-welfare-in-colleges-and-schools-of-veterinary-medicine
#19
Linda K Lord, Suzanne T Millman, Lawrence Carbone, Nigel Cook, Andrew Fisher, Dorothy McKeegan, David Morton, Ed Pajor, Jose M Peralta, Sheilah Ann Robertson, Janice Siegford, P Gary Egrie, Ted Y Mashima, Patricia V Turner, Gail C Golab, Emily Patterson-Kane
No abstract text is available yet for this article.
March 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28256519/autophagy-down-regulates-pro-inflammatory-mediators-in-bv2-microglial-cells-and-rescues-both-lps-and-alpha-synuclein-induced-neuronal-cell-death
#20
Claudio Bussi, Javier Maria Peralta Ramos, Daniela S Arroyo, Emilia A Gaviglio, Jose Ignacio Gallea, Ji Ming Wang, Maria Soledad Celej, Pablo Iribarren
Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated with autophagy dysregulation, and drugs modulating autophagy have been successful in several animal models. Microglial cells are phagocytes in the central nervous system (CNS) that become activated in pathological conditions and determine the fate of other neural cells. Here, we studied the effects of autophagy on the production of pro-inflammatory molecules in microglial cells and their effects on neuronal cells...
March 3, 2017: Scientific Reports
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