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https://www.readbyqxmd.com/read/28812454/risk-factors-for-intrapartum-acidemia-a-cohort-study
#1
Stina Wretler, Lennart Nordström, Sophie Graner, Malin Holzmann
PURPOSE: Birth acidemia is associated with short- and long-term morbidity in the child. Optimal intrapartum surveillance and timely interventions may reduce the incidence of these outcomes. Knowledge about conditions which increase the risks might be beneficial for optimal care. The aim with this study was to identify factors which increased the risk for lactacidemia in fetal scalp blood. MATERIALS AND METHODS: A secondary analysis of a cohort study performed at Karolinska University Hospital Stockholm Sweden between February 2009 and February 2011...
August 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28791818/combined-screening-for-early-and-late-pre-eclampsia-and-intrauterine-growth-restriction-by-maternal-history-uterine-artery-doppler-mean-arterial-pressure-and-biochemical-markers
#2
Ewelina Litwińska, Magdalena Litwińska, Przemysław Oszukowski, Krzysztof Szaflik, Piotr Kaczmarek
BACKGROUND: Pre-eclampsia is a systemic disease connected with high maternal and fetal morbidity and mortality. Despite significant progress achieved in perinatal medicine, pre-eclampsia is still one of the most significant current problems in obstetrics. OBJECTIVES: The aim of the study was to establish diagnostic algorithms for early and late pre-eclampsia (PE) and intrauterine growth restriction (IUGR). MATERIAL AND METHODS: A total of 320 pregnant women between 11 + 0 and 13 + 6 weeks of gestation were recruited for a case-control study...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28783242/re-conceptualising-stillbirth-and-revisiting-birth-surveillance
#3
K S Joseph, Melanie Basso, Cheryl Davies, Lily Lee
The increased focus on stillbirth related issues in recent years has brought several previously neglected issues 'out of the shadows' [1] and highlighted the need for greater preventive efforts and better care for bereaved mothers and families. Some issues (such as the option of cesarean delivery for fetal death at late gestation [2], viewing the fetus following pregnancy termination for a fetal anomaly [3,4] and acknowledgement of paternal grief and anxiety [5]) reflect a substantial shift from previous traditions in clinical practice...
August 7, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28782142/influence-of-gestational-diabetes-on-the-fetal-autonomic-nervous-system-a-study-using-phase-rectified-signal-averaging-analysis
#4
Silvia M Lobmaier, Javier U Ortiz, Maria Sewald, Alexander Müller, Georg Schmidt, Bernhard Haller, Renate Oberhoffer, Karl T M Schneider, Dino A Giussani, Annette Wacker-Gußmann
OBJECTIVES: Maternal gestational diabetes (GDM) is known to influence fetal physiology. Phase-rectified signal averaging (PRSA), an innovative signal processing technique, can be used to investigate signals obtained from fetal heart. The PRSA calculated variables "average acceleration capacity" (AAC) and "average deceleration capacity" (ADC) are established indices of autonomic nervous system (ANS) function. The aim of this study was to evaluate the influence of gestational diabetes on the fetal ANS in human pregnancy using PRSA...
August 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28780660/update-on-valvular-heart-disease-in-pregnancy
#5
REVIEW
Lucy M Safi, Sarah V Tsiaras
Valvular heart disease in women of childbearing age poses an increased risk of adverse maternal and fetal outcomes, and management in pregnancy can be challenging. Ideally, patients with suspected valvular disease should have preconception counseling by a multidisciplinary team including cardiologists with expertise in pregnancy and a maternal-fetal medicine specialist. Preconception planning should include a cardiac assessment of maternal risk, determination of frequency of surveillance, and a cardiovascular management plan during delivery...
September 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28755466/hypospadias-intrauterine-growth-restriction-and-abnormalities-of-the-placenta
#6
M Hassan Toufaily, Drucilla J Roberts, Marie-Noel Westgate, Anne-Therese Hunt, Lewis B Holmes
BACKGROUND: Hypospadias is more common among male infants with growth restriction, defined as a birth weight less than the 10(th) centile, than in infants with a normal birth weight. Intrauterine growth retardation (IUGR) has been associated, also, with abnormalities of the placenta, such as maternal vascular malperfusion. In a consecutive sample of newborn infants, the association between hypospadias, IUGR and abnormalities of the placenta could be analyzed. METHODS: Affected infants were identified among 289,365 liveborn and stillborn infants in the Active Malformations Surveillance Program between 1972 and 2012...
July 29, 2017: Birth defects research
https://www.readbyqxmd.com/read/28746265/prevalence-of-rubella-antibodies-among-children-in-the-democratic-republic-of-the-congo
#7
Vivian H Alfonso, Reena H Doshi, Patrick Mukadi, Stephen G Higgins, Nicole A Hoff, Ado Bwaka, Guillaume Ngoie Mwamba, Emile Okitolonda, Jean-Jacques Muyembe, Sue Gerber, Anne W Rimoin
BACKGROUND: While generally mild in children, rubella infection in early pregnancy can lead to miscarriage, fetal death or congenital rubella syndrome (CRS). Rubella vaccination is not yet available as a part of routine immunization in the Democratic Republic of the Congo (DRC) and the burden of infection is unknown. METHODS: In collaboration with the 2013-2014 DRC Demographic and Health Survey (DHS), a serosurvey was carried out to assess population immunity to vaccine preventable diseases...
July 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28744700/evaluation-of-the-completeness-data-quality-and-timeliness-of-fetal-mortality-surveillance-in-wyoming-2006-2013
#8
Alexia V Harrist, Ashley Busacker, Charlan D Kroelinger
Purpose The number of fetal deaths in the United States each year exceeds that of infant deaths. High quality fetal death certificate data are necessary for states to effectively address preventable fetal deaths. We evaluated completeness of detection of fetal deaths among Wyoming residents that occur out-of-state, quality of cause-of-death data, and timeliness of Wyoming fetal death certificate registration during 2006-2013. Description The numbers of out-of-state fetal deaths among Wyoming residents recorded by Wyoming surveillance and reported by the National Vital Statistics System were compared...
July 25, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28742678/committee-opinion-no-713-antenatal-corticosteroid-therapy-for-fetal-maturation
#9
(no author information available yet)
Corticosteroid administration before anticipated preterm birth is one of the most important antenatal therapies available to improve newborn outcomes. A single course of corticosteroids is recommended for pregnant women between 24 0/7 weeks and 33 6/7 weeks of gestation who are at risk of preterm delivery within 7 days, including for those with ruptured membranes and multiple gestations. It also may be considered for pregnant women starting at 23 0/7 weeks of gestation who are at risk of preterm delivery within 7 days, based on a family's decision regarding resuscitation, irrespective of membrane rupture status and regardless of fetal number...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742672/committee-opinion-no-713-summary-antenatal-corticosteroid-therapy-for-fetal-maturation
#10
(no author information available yet)
Corticosteroid administration before anticipated preterm birth is one of the most important antenatal therapies available to improve newborn outcomes. A single course of corticosteroids is recommended for pregnant women between 24 0/7 weeks and 33 6/7 weeks of gestation who are at risk of preterm delivery within 7 days, including for those with ruptured membranes and multiple gestations. It also may be considered for pregnant women starting at 23 0/7 weeks of gestation who are at risk of preterm delivery within 7 days, based on a family's decision regarding resuscitation, irrespective of membrane rupture status and regardless of fetal number...
August 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28730376/lower-urinary-tract-obstruction-fetal-intervention-based-on-prenatal-staging
#11
Rodrigo Ruano, Timothy Dunn, Michael C Braun, Joseph R Angelo, Adnan Safdar
The authors present an overview of lower urinary tract obstruction (LUTO) in the fetus with a particular focus on the insult to the developing renal system. Diagnostic criteria along with the challenges in estimating long-term prognosis are reviewed. A proposed prenatal LUTO disease severity classification to guide management decisions with fetal intervention to maintain or salvage in utero and neonatal pulmonary and renal function is also discussed. Stage I LUTO (mild form) is characterized by normal amniotic fluid index after 18 weeks, normal kidney echogenicity, no renal cortical cysts, no evidence of renal dysplasia, and favorable urinary biochemistries when sampled between 18 and 30 weeks; prenatal surveillance is recommended...
July 21, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28729313/fetal-doppler-velocimetry-and-bronchopulmonary-dysplasia-risk-among-growth-restricted-preterm-infants-an-observational-study
#12
Alessandra Lio, Paolo Rosati, Roberta Pastorino, Francesco Cota, Milena Tana, Chiara Tirone, Claudia Aurilia, Cinzia Ricci, Alessandro Gambacorta, Angela Paladini, Ilenia Mappa, Silvia Buongiorno, Gian Franco Zannoni, Costantino Romagnoli, Giovanni Vento
OBJECTIVE: To investigate whether fetal growth restriction (FGR) diagnosis, based on pathological prenatal fetal Doppler velocimetry, is associated with bronchopulmonary dysplasia (BPD) independently of being small for gestational age (SGA) per se at birth among very preterm infants. DESIGN: Prospective, observational study. FGR was defined as failing fetal growth in utero and fetal Doppler velocimetry abnormalities. SETTING: Policlinico Universitario Agostino Gemelli, Roma, Italy...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28723858/maternal-hepatitis-b-virus-infection-and-pregnancy-outcomes-a-hospital-based-case-control-study-in-wuhan-china
#13
Zhihua Wan, Aifen Zhou, Huiping Zhu, Xiaofang Lin, Dan Hu, Songxu Peng, Bin Zhang, Yukai Du
GOALS: To examine the impact of maternal hepatitis B virus infection on pregnancy outcomes. BACKGROUND: Studies regarding hepatitis B virus infection and pregnancy outcomes are limited with inconsistent results, and none of them have evaluated the effect of maternal viral load in pregnancy on pregnancy outcomes. STUDY: A hospital-based case-control study was conducted. In total, 1728 hepatitis B surface antigen (HBsAg)-positive women who delivered consecutively at Wuhan Women and Children Medical and Healthcare Center, Wuhan, China, from June 2008 to May 2015, were compared with 1497 HBsAg-negative women giving birth in the same hospital during the same period who were randomly identified and selected from the computerized medical record database in parallel...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28713331/thyroid-stimulating-hormone-receptor-antibodies-in-pregnancy-clinical-relevance
#14
REVIEW
Ines Bucci, Cesidio Giuliani, Giorgio Napolitano
Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. TRAbs are heterogeneous for molecular and functional properties and are subdivided into activating (TSAbs), blocking (TBAbs), or neutral (N-TRAbs) depending on their effect on TSHR...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28709760/clinical-and-pathologic-implications-of-extending-the-spectrum-of-maternal-autoantibodies-reactive-with-ribonucleoproteins-associated-with-cutaneous-and-now-cardiac-neonatal-lupus-from-ssa-ro-and-ssb-la-to-u1rnp
#15
REVIEW
Peter M Izmirly, Marc K Halushka, Avi Z Rosenberg, Sean Whelton, Khodayar Rais-Bahrami, Dilip S Nath, Hilary Parton, Robert M Clancy, Sara Rasmussen, Amit Saxena, Jill P Buyon
While the relationship between maternal connective tissue diseases and neonatal rashes was described in the 1960s and congenital heart block in the 1970s, the "culprit" antibody reactivity to the SSA/Ro-SSB/La ribonucleoprotein complex was not identified until the 1980s. However, studies have shown that approximately 10-15% of cases of congenital heart block are not exposed to anti-SSA/Ro-SSB/La. Whether those cases represent a different disease entity or whether another antibody is associated has yet to be determined...
July 12, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28703927/reducing-the-primary-cesarean-birth-rate-a-quality-improvement-project
#16
Julie A Javernick, Amy Dempsey
INTRODUCTION: Research continues to support vaginal birth as the safest mode of childbirth, but despite this, cesarean birth has become the most common surgical procedure performed on women. The rate has increased 500% since the 1970s without a corresponding improvement in maternal or neonatal outcomes. A Colorado community hospital recognized that its primary cesarean birth rate was higher than national and state benchmark levels. To reduce this rate, the hospital collaborated with its largest maternity care provider group to implement a select number of physiologic birth practices and measure improvement in outcomes...
July 13, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28701023/preterm-preeclampsia-and-timing-of-delivery-a-systematic-literature-review
#17
José Paulo de Siqueira Guida, Fernanda Garanhani Surita, Mary Angela Parpinelli, Maria Laura Costa
Introduction Preeclampsia, a multifactorial disease with pathophysiology not yet fully understood, is a major cause of maternal and perinatal morbidity and mortality, especially when preterm. The diagnosis is performed when there is an association between arterial hypertension and proteinuria or evidence of severity. There are unanswered questions in the literature considering the timing of delivery once preterm preeclampsia has been diagnosed, given the risk of developing maternal complications versus the risk of adverse perinatal outcomes associated with prematurity...
July 12, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28669036/genomic-and-antigenic-relationships-between-two-hobi-like-strains-and-other-members-of-the-pestivirus-genus
#18
Ana Cristina S Mósena, Samuel P Cibulski, Matheus N Weber, Simone Silveira, Mariana S Silva, Fabiana Q Mayer, Paulo M Roehe, Cláudio W Canal
'HoBi'-like viruses comprise a putative new species within the genus Pestivirus of the family Flaviviridae. 'HoBi'-like viruses have been detected worldwide in batches of fetal calf serum, in surveillance programs for bovine pestiviruses and from animals presenting clinical signs resembling bovine viral diarrhea virus (BVDV)-associated diseases. To date, few complete genome sequences of 'HoBi'-like viruses are available in public databases. Moreover, detailed analyses of such genomes are still scarce. In an attempt to expand data on the genetic diversity and biology of pestiviruses, two genomes of 'HoBi'-like viruses recovered from Brazilian cattle were described and characterized in this study...
July 1, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28661021/outcome-of-cesarean-scar-pregnancy-a-systematic-review-and-meta-analysis
#19
REVIEW
Giuseppe Calì, Ilan E Timor-Trisch, Josè Palacios-Jaraquemada, Ana Monteaugudo, Danilo Buca, Francesco Forlani, Alessandra Familiari, Giovanni Scambia, Ganesh Acharya, Francesco D'Antonio
OBJECTIVE: To explore the outcome of women managed expectantly following a diagnosis of caesarean scar pregnancy (CSP). METHODS: The outcomes observed were: severe first trimester vaginal bleeding, clinical symptoms (abdominal pain, vaginal bleeding) requiring treatment, uncomplicated miscarriage, complicated miscarriage requiring intervention, first or second trimester uterine rupture, first or second trimester hysterectomy, third trimester bleeding, third trimester uterine rupture, third trimester hysterectomy, maternal death, occurrence of abnormally invasive placenta (AIP), prevalence of placenta percreta, ultrasound signs suggestive of AIP, liveborn fetuses...
June 29, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28660654/teleultrasound-how-accurate-are-we
#20
Nader Z Rabie, Adam T Sandlin, Kevin A Barber, Songthip Ounpraseuth, Wendy Nembhard, Everett F Magann, Curtis Lowery
OBJECTIVES: Ultrasound serves an important role in the prenatal diagnosis of fetal structural anomalies. Recently, there has been increased use of teleultrasound protocols. We aimed to evaluate the sensitivity and accuracy of teleultrasound. METHODS: We conducted an Institutional Review Board-approved retrospective cohort study determining the sensitivity and accuracy of teleultrasound. In addition, we evaluated the number of ultrasound examinations required to complete an anatomic survey...
June 29, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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