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https://www.readbyqxmd.com/read/29929978/toll-like-receptor-2-deficiency-hyperactivates-the-foxo1-transcription-factor-and-induces-aging-associated-cardiac-dysfunction-in-mice
#1
Kondapalli Mrudula Spurthi, Mohsen Sarikhani, Sneha Mishra, Perumal Arumugam Desingu, Shikha Yadav, Swathi Rao, Sangeeta Maity, Ankit Kumar Tamta, Shweta Kumar, Shamik Majumdar, Aditi Jain, Aishwarya Raghuraman, Danish Khan, Ishwar Singh, Rosa J Samuel, Subbaraya G Ramachandra, Dipankar Nandi, Nagalingam R Sundaresan
Toll-like receptors (TLRs) are a family of pattern-recognition receptors involved in innate immunity. Previous studies have shown that TLR2 inhibition protects the heart from acute stress, including myocardial infarction and doxorubicin-induced cardiotoxicity in animal models. However, the role of TLR2 in the development of aging-associated heart failure is not known. In this work, we studied aging-associated changes in structure and function of TLR2- deficient mice hearts. Whereas young TLR2-KO mice did not develop marked cardiac dysfunction, 8- and 12-months-old TLR2-KO mice exhibited spontaneous adverse cardiac remodeling and cardiac dysfunction in an age-dependent manner...
June 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29928977/the-melas-mutation-m-3243a-g-promotes-reactivation-of-fetal-cardiac-genes-and-an-epithelial-mesenchymal-transition-like-program-via-dysregulation-of-mirnas
#2
Salvador Meseguer, Joaquin Panadero, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Giacomo Pietro Comi, M-Eugenia Armengod
The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is mostly caused by mutation m.3243A>G in mitochondrial tRNALeu(UUR) gene...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29925843/intraamniotic-zika-virus-inoculation-of-pregnant-rhesus-macaques-produces-fetal-neurologic-disease
#3
Lark L Coffey, Rebekah I Keesler, Patricia A Pesavento, Kevin Woolard, Anil Singapuri, Jennifer Watanabe, Christina Cruzen, Kari L Christe, Jodie Usachenko, JoAnn Yee, Victoria A Heng, Eliza Bliss-Moreau, J Rachel Reader, Wilhelm von Morgenland, Anne M Gibbons, Kenneth Jackson, Amir Ardeshir, Holly Heimsath, Sallie Permar, Paranthaman Senthamaraikannan, Pietro Presicce, Suhas G Kallapur, Jeffrey M Linnen, Kui Gao, Robert Orr, Tracy MacGill, Michelle McClure, Richard McFarland, John H Morrison, Koen K A Van Rompay
Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. The GD41-inoculated animal, experiencing fetal death 7 days later, has high virus levels in fetal and placental tissues, implicating ZIKV as cause of death...
June 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29924462/timing-and-mechanism-of-conceptus-demise-in-a-complement-regulatory-membrane-protein-deficient-mouse
#4
Michael P Triebwasser, Xiaobo Wu, Paula Bertram, Dennis E Hourcade, Donald Michael Nelson, John P Atkinson
PROBLEM: Crry is a widely expressed type 1 transmembrane complement regulatory protein in rodents which protects self-tissue by downregulating C3 activation. Crry-/- concepti produced by Crry+/-  × Crry+/- matings are attacked by maternal complement system leading to loss before day 10. The membrane attack complex is not the mediator of this death. We hypothesized that the ability of C3b to engage the alternative pathway's feedback loop relatively unchecked on placental membranes induces the lesion yielding the demise of the Crry-/- mouse...
June 20, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29922597/recent-advances-in-replication-and-infection-of-human-parvovirus-b19
#5
REVIEW
Safder S Ganaie, Jianming Qiu
Parvovirus B19 (B19V) is pathogenic to humans and causes bone marrow failure diseases and various other inflammatory disorders. B19V infection exhibits high tropism for human erythroid progenitor cells (EPCs) in the bone marrow and fetal liver. The exclusive restriction of B19V replication to erythroid lineage cells is partly due to the expression of receptor and co-receptor(s) on the cell surface of human EPCs and partly depends on the intracellular factors essential for virus replication. We first summarize the latest developments in the viral entry process and the host cellular factors or pathways critical for B19V replication...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29921302/effectiveness-of-pregnant-women-s-active-participation-in-their-antenatal-care-for-the-control-of-malaria-and-anaemia-in-pregnancy-in-ghana-a-cluster-randomized-controlled-trial
#6
Gifty Dufie Ampofo, Harry Tagbor, Imelda Bates
BACKGROUND: The burden of malaria and anaemia in pregnancy remains high despite the availability of proven efficacious antenatal care interventions. Sub-optimal uptake of the interventions may be due to inadequate active participation of pregnant women in their antenatal care. It was hypothesized that providing opportunities for pregnant women to improve upon active participation in their antenatal care through malaria and anaemia point-of-care testing would improve adherence to ANC recommendations and interventions and lead to better pregnancy outcomes...
June 19, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29920817/predictive-accuracy-of-cerebroplacental-ratio-for-adverse-perinatal-and-neurodevelopmental-outcomes-in-suspected-fetal-growth-restriction-systematic-review-and-meta-analysis
#7
REVIEW
Agustin Conde-Agudelo, José Villar, Stephen H Kennedy, Aris T Papageorghiou
OBJECTIVE: The cerebroplacental ratio (CPR) has been proposed for the routine surveillance of pregnancies with suspected fetal growth restriction (FGR), but the predictive performance of this test is unclear. The aim of this study was to determine the accuracy of the CPR for predicting adverse perinatal and neurodevelopmental outcomes in suspected FGR. METHODS: PubMed, EMBASE, CINAHL, and Lilacs (all from inception to July 31, 2017) were searched for cohort or cross-sectional studies that reported on the accuracy of the CPR for predicting adverse perinatal and/or neurodevelopmental outcomes in singleton pregnancies with antenatally suspected FGR based on sonographic parameters...
June 19, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29915747/audit-of-emergency-obstetric-referrals-from-a-secondary-level-hospital-in-haryana-north-india
#8
Shashi Kant, Ravneet Kaur, Sumit Malhotra, Partha Haldar, Akhil Dhanesh Goel
Background: The maternal mortality ratio in India is high. An effective emergency obstetric care (EmOC) strategy has been identified as a priority to reduce maternal deaths. Since the capacity of different levels of public health facilities to provide EmOC is varied, an effective referral system is crucial. However, few studies have evaluated the functioning and quality of referral systems in India. A systematic monitoring of referrals helps to identify current gaps in the provision of essential obstetric care...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915352/the-wave2-scaffold-hem-1-is-required-for-transition-of-fetal-liver-hematopoiesis-to-bone-marrow
#9
Lijian Shao, Jianhui Chang, Wei Feng, Xiaoyan Wang, Elizabeth A Williamson, Ying Li, Amir Schajnovitz, David Scadden, Luke J Mortensen, Charles P Lin, Linheng Li, Ariel Paulson, James Downing, Daohong Zhou, Robert A Hromas
The transition of hematopoiesis from the fetal liver (FL) to the bone marrow (BM) is incompletely characterized. We demonstrate that the Wiskott-Aldrich syndrome verprolin-homologous protein (WAVE) complex 2 is required for this transition, as complex degradation via deletion of its scaffold Hem-1 causes the premature exhaustion of neonatal BM hematopoietic stem cells (HSCs). This exhaustion of BM HSC is due to the failure of BM engraftment of Hem-1-/- FL HSCs, causing early death. The Hem-1-/- FL HSC engraftment defect is not due to the lack of the canonical function of the WAVE2 complex, the regulation of actin polymerization, because FL HSCs from Hem-1-/- mice exhibit no defects in chemotaxis, BM homing, or adhesion...
June 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29914408/maternal-and-fetal-prognosis-of-subsequent-pregnancy-in-black-african-women-with-peripartum-cardiomyopathy
#10
Nobila Valentin Yaméogo, André Koudnoaga Samadoulougou, Larissa Justine Kagambèga, Koudougou Jonas Kologo, Georges Rosario Christian Millogo, Anna Thiam, Charles Guenancia, Patrice Zansonré
BACKGROUND: The aim of this study was to describe maternal and fetal outcomes after pregnancy complicated by peripartum cardiomyopathy (PPCM). METHODS: We included women that had subsequent pregnancy (SSP) after PPCM and assessed maternal prognosis and pregnancy outcomes, in-hospital up to one week after discharge. Clinical and echocardiographic data were collected comparing alive and deceased women. Factors associated with pregnancy outcomes were assessed. RESULTS: Twenty-nine patients were included, with a mean age of 26...
June 18, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29914278/maternal-fetal-and-neonatal-outcome-among-different-types-of-hypertensive-disorders-associating-pregnancy-needing-intensive-care-management
#11
Ahmed M Maged, Ameer Elsherief, Hany Hassan, Doaa Salaheldin, Khaled A Omran, Maged Almohamady, Sherif Dahab, Radwa Fahmy, Ahmed AbdelHak, Amira Y Shoab, Rehab Lotfy, Yossra S Lasheen, Hala Nabil, Sahar M Y Elbaradie
OBJECTIVE: To assess the relation between maternal, fetal and neonatal outcomes and different forms of hypertensive disorders associating pregnancy in women needed intensive care units (ICU) admission. METHODS: A prospective case control study conducted on 1238 women admitted to hypertensive intensive care unit at three university hospitals. They were classified into four groups. Group I included 472 women with severe preeclampsia (PE), Group II included 243 women with eclampsia (E); Group III included 396 women diagnosed with E associated with HELLP syndrome and Group IV included 127 women diagnosed as HELLP syndrome...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29913325/mucosal-disease-like-lesions-caused-by-hobi-like-pestivirus-in-brazilian-calves-in-2010-2011-clinical-pathological-immunohistochemical-and-virological-characterization
#12
Raquel A S Cruz, Wagner B Rodrigues, Simone Silveira, Victor H S Oliveira, Camila Gonçalves Campos, Ronaldo V Leite Filho, Fabiana M Boabaid, David Driemeier, Cláudio W Canal, Amauri A Alfieri, Caroline A Pescador, Edson M Colodel
A HoBi-like pestivirus was first described in 2004 in a Brazilian fetal bovine serum that was exported to Germany. Nevertheless, it is believed that the virus had been present since the 1990's, when it was detected in buffalos of Brazilian origin. Reproductive and respiratory diseases have been reported since 2001 in cattle, and more recently, diseases accompanied by a clinical presentation of mucosal disease-like (MD-like lesions have been reported as well. In the present study, the authors reported the oldest case of MD--like in cattle, associated with a HoBi-like pestivirus infection...
June 11, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29910107/maternal-sleep-during-pregnancy-and-poor-fetal-outcomes-a-scoping-review-of-the-literature-with-meta-analysis
#13
REVIEW
Jane Warland, Jillian Dorrian, Janna L Morrison, Louise M O'Brien
There is a wealth of evidence to say that sleep impacts maternal health during pregnancy, however, little has been published on fetal health and maternal sleep. This scoping review summarises current literature on maternal sleep including sleep disordered breathing, sleep quality, sleep duration and supine sleep position, as these relate to fetal outcomes specifically birth weight, growth, preterm birth and stillbirth. An overall interpretation of the studies evaluated shows that events occurring during maternal sleep such as obstructive sleep apnea, sleep disruption and sleep position may have a negative effect on the fetus resulting in altered growth, gestational length and even death...
March 27, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29908431/smoking-ban-and-health-at-birth-evidence-from-hungary
#14
Tamás Hajdu, Gábor Hajdu
In 2012, smoking restrictions were extended to hospitality venues in Hungary. Women working in bars and restaurants were primarily affected by the intervention. In this research, we analyze the effect of this smoking ban on the outcomes of their pregnancies. Using individual live birth, fetal loss, and infant mortality registry data, we examine the probability of live birth, indicators of health at birth, and the probability of death in the first year of life. We apply a difference-in-differences framework and show that the smoking ban has improved health at birth...
June 13, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#15
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29906222/analysis-of-the-microrna-signature-driving-adaptive-right-ventricular-hypertrophy-in-an-ovine-model-of-congenital-heart-disease
#16
Rebecca Johnson Kameny, Youping He, Terry Zhu, Wenhui Gong, Gary W Raff, Cheryl J Chapin, Sanjeev A Datar, Jason Boehme, Akiko Hata, Jeffrey R Fineman
The right ventricular (RV) response to pulmonary arterial hypertension (PAH) is heterogeneous. Most patients have maladaptive changes with RV dilation and failure while some-especially patients with PAH secondary to congenital heart disease (CHD)-have an adaptive response with hypertrophy and preserved systolic function. Mechanisms for RV adaptation to PAH are unknown despite RV function being a primary determinant of mortality. In our CHD ovine model with fetally-implanted aortopulmonary shunt (shunt lambs), we previously demonstrated an adaptive physiologic RV response to increased afterload with hypertrophy...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29902589/prevalence-and-associated-factors-for-agenesis-of-corpus-callosum-in-emilia-romagna-1981-2015
#17
Elisa Ballardini, Pietro Marino, Elisa Maietti, Gianni Astolfi, Amanda J Neville
Agenesis and hypoplasia of the corpus callosum (ACC and HCC) are heterogeneous group with a large variation in published prevalence based on few population based studies. The aim of this work is to describe prevalence, associated factors and other malformations present in cases with either agenesis or hypoplasia of the corpus callosum, using a population-based database of all malformations diagnosed in Emilia-Romagna, Italy, (the Emilia-Romagna Registry on Congenital Malformations, IMER). This registry links and integrates hospital discharge records, birth certificates with cases reported by referral clinicians to identify all structural malformations diagnosed within one year of life regarding live birth, fetal death or termination of pregnancy due to fetal malformations (TOPFA)...
June 11, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29902448/postponing-early-intrauterine-transfusion-with-intravenous-immunoglobulin-treatment-the-petit-study-on-severe-hemolytic-disease-of-the-fetus-and-newborn
#18
Carolien Zwiers, Johanna G van der Bom, Inge L van Kamp, Nan Van Geloven, Enrico Lopriore, John Smoleniec, Roland Devlieger, Pauline E Sim, Marie Anne Ledingham, Eleonor Tiblad, Kenneth J Moise, Karl-Philip Gloning, Mark D Kilby, Timothy G Overton, Ditte S Jørgensen, Katrine V Schou, Bettina Paek, Martin Walker, Emma Parry, Dick Oepkes, Masja de Haas
BACKGROUND: Intrauterine transfusion for severe alloimmunization in pregnancy performed before 20 weeks' gestation is associated with a higher fetal death rate. Intravenous immunoglobulins may prevent hemolysis and could therefore be a non-invasive alternative for early transfusions. OBJECTIVE(S): We evaluated whether maternal treatment with intravenous immunoglobulins defers the development of severe fetal anemia and its consequences in a retrospective cohort to which 12 fetal therapy centers contributed...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29900612/prevalence-antenatal-management-and-perinatal-outcomes-of-monochorionic-monoamniotic-twin-pregnancies-a-collaborative-multicentre-study-in-england-2000-2013
#19
Svetlana V Glinianaia, Judith Rankin, Asma Khalil, Julia Binder, Gareth Waring, Stephen N Sturgiss, Basky Thilaganathan, Therese Hannon
OBJECTIVES: To determine the prevalence of monochorionic monoamniotic (MCMA) twin pregnancies and to describe perinatal outcomes and clinical management of these pregnancies. METHODS: This multicentre cohort study used population-based data on MCMA twin pregnancies from 11 Northern Survey of Twin and Multiple Pregnancy (NorSTAMP) maternity units for the prevalence estimation of MCMA twinning. Pregnancy outcomes at <24 weeks' gestation, antenatal parameters and perinatal outcomes (from ≥24 weeks to the first 28 days of life) were analysed using combined data on pregnancies with confirmed MCMA chorionicity from the NorSTAMP and the Southwest Thames Region of London Obstetric Research Collaborative (STORK) multiple pregnancy cohort for 2000-2013...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29897898/mother-to-child-transmission-of-chikungunya-virus-a-systematic-review-and-meta-analysis
#20
Despina Contopoulos-Ioannidis, Shoshana Newman-Lindsay, Camille Chow, A Desiree LaBeaud
BACKGROUND: Chikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation. METHODOLOGY: We performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis)...
June 13, 2018: PLoS Neglected Tropical Diseases
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