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https://www.readbyqxmd.com/read/28218330/predicting-the-phospholipophilicity-of-monoprotic-positively-charged-amines
#1
S T J Droge, J L M Hermens, S Gutsell, J Rabone, G Hodges
The sorption affinity of eighty-six charged amine structures to phospholipid monolayers (log KIAM) was determined using immobilized artificial membrane high-performance liquid chromatography (IAM-HPLC). The amine compounds covered the most prevalent types of polar groups, widely ranged in structural complexity, and included forty-seven pharmaceuticals, as well as several narcotics and pesticides. Amine type specific corrective increments were used to align log KIAM data with bilayer membrane sorption coefficients (KMW(IAM))...
February 20, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28212384/global-economic-impacts-of-climate-variability-and-change-during-the-20th-century
#2
Francisco Estrada, Richard S J Tol, Wouter J W Botzen
Estimates of the global economic impacts of observed climate change during the 20th century obtained by applying five impact functions of different integrated assessment models (IAMs) are separated into their main natural and anthropogenic components. The estimates of the costs that can be attributed to natural variability factors and to the anthropogenic intervention with the climate system in general tend to show that: 1) during the first half of the century, the amplitude of the impacts associated with natural variability is considerably larger than that produced by anthropogenic factors and the effects of natural variability fluctuated between being negative and positive...
2017: PloS One
https://www.readbyqxmd.com/read/28187517/selective-cysteine-modification-of-metal-free-human-metallothionein-1a-and-its-isolated-domain-fragments-solution-structural-properties-revealed-via-esi-ms
#3
Gordon W Irvine, Melissa Santolini, Martin J Stillman
Human metallothionein 1a, a protein with two cysteine-rich metal-binding domains (α with 11 Cys and β with 9), was analyzed in its metal-free form by selective, covalent Cys modification coupled with ESI-MS techniques. The modification profiles of the isolated β- and α-fragments reacted with p-benzoquinone (Bq), N-ethylmalemide (NEM) and iodoacetamide (IAM) were compared with the full length protein using ESI-mass spectral data to follow the reaction pathway. Under denaturing conditions at low pH, the reaction profile with each modifier followed pathways that resulted in stochastic, Normal distributions of species whose maxima was equal to the mol...
February 10, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28187261/sorption-of-cationic-surfactants-to-artificial-cell-membranes-comparing-phospholipid-bilayers-with-monolayer-coatings-and-molecular-simulations
#4
Niels Timmer, Steven T J Droge
This study reports the distribution coefficient between phospholipid bilayer membranes and PBS medium (DMW,PBS) for 19 cationic surfactants. The method used a sorbent dilution series with solid supported lipid membranes (SSLMs). The existing SSLM protocol, applying a 96 well plate set-up, was adapted to use 1.5 mL glass autosampler vials instead, which facilitated sampling and circumvented several confounding loss processes for some of the cationic surfactants. About 1% of the phospholipids were found to be detached from the SSLM beads, resulting in nonlinear sorption isotherms for compounds with logDMW values above 4...
February 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28181868/the-distributional-impact-of-social-security-policy-options
#5
Kenneth A Couch, Gayle L Reznik, Christopher R Tamborini, Howard M Iams
Using microsimulation, we estimate the effects of three policy proposals that would alter Social Security's eligibility rules or benefit structure to reflect changes in women's labor force activity, marital patterns, and differential mortality among the aged. First, we estimate a set of options related to the duration of marriage required to receive divorced spouse and survivor benefits. Second, we estimate the effects of an earnings sharing proposal with survivor benefits, in which benefits are based entirely on earned benefits with spouses sharing their earnings during years of marriage...
January 2017: Research on Aging
https://www.readbyqxmd.com/read/28178045/assessment-of-transvaginal-ultrasound-cervical-length-image-quality
#6
Rupsa C Boelig, Helen Feltovich, Jean Lea Spitz, Gregory Toland, Vincenzo Berghella, Jay D Iams
OBJECTIVE: To use data from the Cervical Length Education and Review program to evaluate the quality of transvaginal cervical length ultrasonography by trained imagers (ie, ultrasonographers, radiologists, perinatologists). METHODS: This is a retrospective observational study of data from the Cervical Length Education and Review program. Candidates underwent an online lecture series, examination, and submitted a batch of images for review. For a candidate's batch of images to pass, all images must meet at least seven of the nine criteria assessed, the overall batch score needs to be 80% or greater, correct caliper placement must be met for all images, and the same criterion cannot be consistently missed...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28141500/pseudomonas-lactis-sp-nov-and-pseudomonas-paralactis-sp-nov-isolated-from-bovine-raw-milk
#7
Mario von Neubeck, Christopher Huptas, Claudia Glück, Manuel Krewinkel, Marina Stoeckel, Timo Stressler, Lutz Fischer, Jörg Hinrichs, Siegfried Scherer, Mareike Wenning
Five strains, designated WS 4672T, WS 4998, WS 4992T, WS 4997, and WS 5000, isolated from bovine raw milk formed two individual groups in a phylogenetic analysis. The most similar species on the basis of 16S rRNA gene sequences were Pseudomonas azotoformans IAM 1603T, Pseudomonas gessardii CIP 105469T, and Pseudomonas libanensis CIP 105460T showing 99.7-99.6 % similarity. Using rpoD gene sequences Pseudomonas veronii LMG 17761T (93.3 %) was most closely related to strain WS 4672T and Pseudomonas libanensis CIP 105460T to strain WS 4992T (93...
January 29, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28137472/assessment-of-the-chromatographic-lipophilicity-of-eight-cephalosporins-on-different-stationary-phases
#8
Monika Dąbrowska, Małgorzata Starek, Łukasz Komsta, Przemysław Szafrański, Anna Stasiewicz-Urban, Włodzimierz Opoka
The retention behaviors were investigated for a series of eight cephalosporins in thin-layer chromatography (TLC) using stationary phases of RP-2, RP-8, RP-18, NH2, DIOL, and CN chemically bonded silica gel. Additionally, various binary mobile phases (water/methanol and water/acetone) were used in different volume proportions. The retention behavior of the analyzed molecules was defined by RM0 constant. In addition, reversed phase high performance liquid chromatography (RP-HPLC) was performed in lipophilicity studies by using immobilized artificial membrane (IAM) stationary phase...
January 28, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28130991/the-use-of-immobilized-artificial-membrane-chromatography-to-predict-bioconcentration-of-pharmaceutical-compounds
#9
Fotios Tsopelas, Chrysanthos Stergiopoulos, Lamprini-Areti Tsakanika, Maria Ochsenkühn-Petropoulou, Anna Tsantili-Kakoulidou
The potential of immobilized artificial membrane chromatography (IAM) to predict bioconcentration factors (BCF) of pharmaceutical compounds in aquatic organisms was studied. For this purpose, retention factors extrapolated to pure aqueous phase, logkw(IAM), of 27 drugs were measured on an IAM stationary phase, IAM.PC.MG type. The data were combined with retention factors on two IAM columns, IAM.PC.MG and IAM.PC.DD2 types, reported previously by our research group and correlated with logBCF values predicted by Estimation Program Interface (EPI Suite) Software...
January 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28124782/azohydromonas-riparia-sp-nov-and-azohydromonas-ureilytica-sp-nov-isolated-from-a-riverside-soil-in-south-korea
#10
Tuan Manh Nguyen, Jaisoo Kim
White and pale yellow coloured bacteria were isolated from the riverside soil, Daejeon, South Korea, and were designated UCM-11(T), UCM-F25, and UCM-80(T). We found that all strains were able to reduce nitrate, and the cells were aerobic and motile. The DNA G+C contents of UCM-11(T), UCM-F25, and UCM-80(T) were between 68.9 to 71.2 mol% and the main ubiquinone was observed as Q-8. Based on16S rRNA gene sequences, strains UCM-11(T) and UCM-F25 were found to closely match with Azohydromonas australica IAM 12664(T) (98...
January 26, 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28114255/novel-targeted-therapies-for-metastatic-melanoma
#11
Wade T Iams, Jeffrey A Sosman, Sunandana Chandra
Oncogene-targeted therapy is a major component of precision oncology, and although patients with metastatic melanoma have experienced improved outcomes with this strategy, there are a number of potential therapeutic targets currently under study that may further increase the drug armamentarium for this patient population. In this review, we discuss the landscape of targeted therapies for patients with advanced melanoma, focusing on oncogene mutation-specific targets. In patients with typical BRAF V600-mutant melanoma, combination BRAF and MEK inhibition has surpassed outcomes compared with monotherapy with BRAF or MEK inhibition alone, and current strategies seek to address inevitable resistance mechanisms...
January 2017: Cancer Journal
https://www.readbyqxmd.com/read/28109502/bilateral-cochlear-nerve-absence-in-a-3-year-old-child-with-vacterl-association
#12
Milan Rudić, Winson Wong, Stuart Viner, David Strachan, Christopher Raine
We report a case of a 3 year old boy with bilateral profound sensorineural hearing loss diagnosed from New Born Hearing Screening, with severe form of VACTERL association. He was referred to our Cochlear Implant Unit for assessment with regard to the possibility of cochlear implantation. MRI findings have showed bilateral vestibulocochlear cystic abnormalities. Only single nerve noted within the IAM on the right and likely single nerve within the IAM on the left. Hence, decision was made not to offer cochlear implantation...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109204/aquaspirillum-soli-sp-nov-isolated-from-a-soil-sample-in-the-people-s-republic-of-china
#13
Gabriela Moya, Huan Trinh, Zheng-Fei Yan, KyungHwa Won, Jung-Eun Yang, Qi-Jun Wang, MooChang Kook, Tae-Hoo Yi
A Gram-stain-negative, smooth, opaque, white pigmented, helical-shaped and motile bacterium by means of bipolar tufts of flagella, catalase- and oxidase-positive, grew under microaerophilic conditions, was isolated from soil sample of a reed pond in Shangqiu, Henan province, P. R. China. The strain named THG-SQE6T grows well at 25-42 oC, pH 6.5-7.5 and in the presence of 0-1 % (w/v) NaCl. The phylogenetic analysis based on 16S rRNA gene sequence showed that the strain THG-SQE6T was most closely related to Aquaspirillum serpens IAM 13944T (97...
January 19, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28099589/which-coronary-lesions-are-more-prone-to-cause-acute-myocardial-infarction
#14
Taner Sen, Mehmet Ali Astarcioglu, Osman Beton, Lale Dinc Asarcikli, Celal Kilit
Background: According to common belief, most myocardial infarctions (MIs) are due to the rupture of nonsevere, vulnerable plaques with < 70% obstruction. Data from recent trials challenge this belief, suggesting that the risk of coronary occlusion is, in fact, much higher after severe stenosis. The aim of this study was to investigate whether or not acute ST-elevation MIs result from high-grade stenoses by evaluating the presence of coronary collateral circulation (CCC). Methods: We retrospectively included 207 consecutive patients who had undergone primary percutaneous coronary intervention for acute ST-elevation MI...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28079774/a-statewide-progestogen-promotion-program-in-ohio
#15
Jay D Iams, Mary S Applegate, Michael P Marcotte, Martha Rome, Michael A Krew, Jennifer L Bailit, Heather C Kaplan, Jessi Poteet, Melissa Nance, David S McKenna, Hetty C Walker, Jennifer Nobbe, Lakshmi Prasad, Maurizio Macaluso, Carole Lannon
OBJECTIVE: To promote use of progestogen therapy to reduce premature births in Ohio by 10%. METHODS: The Ohio Perinatal Quality Collaborative initiated a quality improvement project in 2014 working with clinics at 20 large maternity hospitals, Ohio Medicaid, Medicaid insurers, and service agencies to use quality improvement methods to identify eligible women and remove treatment barriers. The number of women eligible for prophylaxis, the percent prescribed a progestogen before 20 and 24 weeks of gestation, and barriers encountered were reported monthly...
February 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28076446/downscaling-global-emissions-and-its-implications-derived-from-climate-model-experiments
#16
Shinichiro Fujimori, Manabu Abe, Tsuguki Kinoshita, Tomoko Hasegawa, Hiroaki Kawase, Kazuhide Kushida, Toshihiko Masui, Kazutaka Oka, Hideo Shiogama, Kiyoshi Takahashi, Hiroaki Tatebe, Minoru Yoshikawa
In climate change research, future scenarios of greenhouse gas and air pollutant emissions generated by integrated assessment models (IAMs) are used in climate models (CMs) and earth system models to analyze future interactions and feedback between human activities and climate. However, the spatial resolutions of IAMs and CMs differ. IAMs usually disaggregate the world into 10-30 aggregated regions, whereas CMs require a grid-based spatial resolution. Therefore, downscaling emissions data from IAMs into a finer scale is necessary to input the emissions into CMs...
2017: PloS One
https://www.readbyqxmd.com/read/27988185/global-land-use-allocation-model-linked-to-an-integrated-assessment-model
#17
Tomoko Hasegawa, Shinichiro Fujimori, Akihiko Ito, Kiyoshi Takahashi, Toshihiko Masui
We developed a global land-use allocation model that can be linked to integrated assessment models (IAMs) with a coarser spatial resolution. Using the model, we performed a downscaling of the IAMs' regional aggregated land-use projections to obtain a spatial land-use distribution, which could subsequently be used by Earth system models for global environmental assessments of ecosystem services, food security, and climate policies. Here we describe the land-use allocation model, discuss the verification of the downscaling technique, and explain the influences of the downscaling on estimates of land-use carbon emissions...
December 14, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27974157/development-of-double-chain-phosphatidylcholine-functionalized-polymeric-monoliths-for-immobilized-artificial-membrane-chromatography
#18
Qiqin Wang, Kun Peng, Weijia Chen, Zhen Cao, Peijie Zhu, Yumei Zhao, Yuqiang Wang, Haibo Zhou, Zhengjin Jiang
This study described a simple synthetic methodology for preparing biomembrane mimicking monolithic column. The suggested approach not only simplifies the preparation procedure but also improves the stability of double chain phosphatidylcholine (PC) functionalized monolithic column. The physicochemical properties of the optimized monolithic column were characterized by scanning electron microscopy, energy-dispersive X-ray spectrometry, and nano-LC. Satisfactory column permeability, efficiency, stability and reproducibility were obtained on this double chain PC functionalized monolithic column...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27969535/ps01-68-heterogeneous-clinical-syndromes-existing-within-patients-with-stage-iv-kras-mutant-non-small-cell-lung-cancer-topic-medical-oncology
#19
Wade T Iams, Hui Yu, Yu Shyr, Tejas Patil, Leora Horn, Caroline McCoach, Karen Kelly, Robert Doebele, David R Camidge
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27923442/bullying-and-defending-behavior-the-role-of-explicit-and-implicit-moral-cognition
#20
Tiziana Pozzoli, Gianluca Gini, Robert Thornberg
Research on bullying has highlighted the role of morality in explaining the different behavior of students during bullying episodes. However, the research has been limited to the analysis of explicit measures of moral characteristics and moral reasoning, whereas implicit measures have yet to be fully considered. To overcome this limitation, this study investigated the association between bullying and defending, on one hand, and both explicit (moral disengagement, self-importance of moral values) and implicit (immediate affect toward moral stimuli [IAMS]) moral components, on the other hand...
December 2016: Journal of School Psychology
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