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https://www.readbyqxmd.com/read/28644732/lipophilicity-and-biomimetic-properties-to-support-drug-discovery
#1
Fotios Tsopelas, Constantinos Giaginis, Anna Tsantili-Kakoulidou
Lipophilicity, expressed as the octanol-water partition coefficient, constitutes the most important property in drug action, influencing both pharmacokinetic and pharmacodynamics processes as well as drug toxicity. On the other hand, biomimetic properties defined as the retention outcome on HPLC columns containing a biological relevant agent, provide a considerable advance for rapid experimental -based estimation of ADME properties in early drug discovery stages. Areas covered: This review highlights the paramount importance of lipophilicity in almost all aspects of drug action and safety...
June 23, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28599896/objectively-measured-short-sleep-duration-and-later-sleep-midpoint-in-pregnancy-are-associated-with-a-higher-risk-of-gestational-diabetes
#2
Francesca L Facco, William A Grobman, Kathryn J Reid, Corette B Parker, Shannon M Hunter, Robert M Silver, Robert C Basner, George R Saade, Grace W Pien, Shalini Manchanda, Judette M Louis, Chia-Ling Nhan-Chang, Judith H Chung, Deborah A Wing, Hyagriv N Simhan, David M Haas, Jay Iams, Samuel Parry, Phyllis C Zee
BACKGROUND: Experimental and epidemiologic data suggest that among non-pregnant adults, sleep duration may be an important risk factor for chronic disease. Although pregnant women commonly complain of poor sleep, few studies have objectively evaluated the quality of sleep in pregnancy or have explored the relationship between sleep disturbances and maternal and perinatal outcomes. OBJECTIVES: Our objective was to examine the relationship between objectively assessed sleep duration, timing and continuity (measured via wrist actigraphy) and maternal cardiovascular and metabolic morbidity specific to pregnancy...
June 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28596636/no-gold-standard-evaluation-of-image-acquisition-methods-using-patient-data
#3
Abhinav K Jha, Eric Frey
Several new and improved modalities, scanners, and protocols, together referred to as image-acquisition methods (IAMs), are being developed to provide reliable quantitative imaging. Objective evaluation of these IAMs on the clinically relevant quantitative tasks is highly desirable. Such evaluation is most reliable and clinically decisive when performed with patient data, but that requires the availability of a gold standard, which is often rare. While no-gold-standard (NGS) techniques have been developed to clinically evaluate quantitative imaging methods, these techniques require that each of the patients be scanned using all the IAMs, which is expensive, time consuming, and could lead to increased radiation dose...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28579562/crystal-structure-and-electrostatic-properties-of-prednisolone-acetate-studied-using-a-transferred-multipolar-atom-model
#4
Ammara Shahid, Sajida Noureen, Muhammad Iqbal Choudhary, Sammer Yousuf, Maqsood Ahmed
Prednisolone acetate {systematic name: 2-[(8S,9S,10R,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate}, is an ophthalmic drug that belongs to the class of corticosteroids. Its crystal structure was refined using the classical independent atom model (IAM) and a transferred multipolar atom model using the ELMAM2 database. The results of both refinements have been compared. The ELMAM2 refinement was found to be superior in terms of the refinement statistics...
June 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28522317/the-association-among-cytochrome-p450-3a-progesterone-receptor-polymorphisms-plasma-17-alpha-hydroxyprogesterone-caproate-concentrations-and-spontaneous-preterm-birth
#5
Martha L Bustos, Steve N Caritis, Kathleen A Jablonski, Uma M Reddy, Yoram Sorokin, John M Thorp, Michael W Varner, Ronald J Wapner, Jay D Iams, Marshall W Carpenter, Alan M Peaceman, Brian M Mercer, Anthony Sciscione, Dwight J Rouse, Susan M Ramin
BACKGROUND: Infants born <37 weeks' gestation are of public health concern since complications associated with preterm birth are the leading cause of mortality in children <5 years of age and a major cause of morbidity and lifelong disability. The administration of 17-alpha hydroxyprogesterone caproate reduces preterm birth by 33% in women with history of spontaneous preterm birth. We demonstrated previously that plasma concentrations of 17-alpha hydroxyprogesterone caproate vary widely among pregnant women and that women with 17-alpha hydroxyprogesterone caproate plasma concentrations in the lowest quartile had spontaneous preterm birth rates of 40% vs rates of 25% in those women with higher concentrations...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28515389/ca-2-in-hybridization-solutions-for-fluorescence-in-situ-hybridization-facilitates-the-detection-of-enterobacteriaceae
#6
Shin Haruta, Takao Iino, Moriya Ohkuma, Ken-Ichiro Suzuki, Yasuo Igarashi
Fluorescence in situ hybridization (FISH) has been employed to identify microorganisms at the single cell level under a microscope. Extensive efforts have been made to improve and extend the FISH technique; however, the development of a widely applicable protocol is a continuing challenge. The present study evaluated the effects of divalent cations in the hybridization solution on the FISH-based detection of various species of bacteria and archaea with rRNA-targeted probes. A flow cytometric analysis after FISH with a standard hybridization buffer detected positive signals from less than 30% of Escherichia coli IAM 1264 cells...
May 18, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28505683/tranexamic-acid-effectively-reduces-blood-loss-and-transfusion-rates-during-simultaneous-bilateral-total-knee-arthroplasty
#7
Hernan A Prieto, Heather K Vincent, Justin T Deen, Dane A Iams, Hari K Parvataneni
No abstract text is available yet for this article.
May 15, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28494993/robust-activation-detection-methods-for-real-time-and-offline-fmri-analysis
#8
Kaya Oguz, Muhammed G Cinsdikici, Ali Saffet Gonul
We propose two contributions with novel approaches to fMRI activation analysis. The first is to apply confidence intervals to locate activations in real-time, and second is a new metric based on robust regression of fMRI signals. These contributions are implemented in our four proposed methods; Instantaneous Activation Method (IAM), Instantaneous Activation Method with Past Blocks (IAMP) for real-time analysis, Task Robust Regression Distance Method (TRRD) for the new metric with robust regression and Instantaneous Robust Regression Distance Method (IRRD) for both contributions...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28489217/intra-aortic-balloon-pump-in-cardiogenic-shock-state-of-the-art
#9
Petronio Generoso Thomaz, Leonel Adelino Moura, Giovana Muramoto, Renato Samy Assad
The clinical definition of cardiogenic shock is that of a low cardiac output and evidence of tissue hypoxia in the presence of adequate blood volume. Cardiogenic shock is the main cause of death related to acute myocardial infarction (AMI), with a mortality rate of 45-70% in the absence of aggressive and highly specialized technical care. The intra-aortic balloon pump (IABP) is one of the most widely used mechanical assisting devices. During the last two decades, about 42% of patients with AMI who evolved with cardiogenic shock received mechanical circulatory assistance with IABP...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28468424/manipulating-surface-plasmon-polaritons-with-infinitely-anisotropic-metamaterials
#10
Zheping Shao, Yihao Yang, Zuojia Wang, Muhiddeen Yahaya, Bin Zheng, Shahram Dehdashti, Huaping Wang, Hongsheng Chen
Guiding surface states through disorders recently has attracted attention of scientists from diverse backgrounds. In this work, we report a robust method to guide surface plasmon polaritons (SPPs) through arbitrary distorted metal surfaces (a kind of disorder), including slopes, bumps, and sharp corners. Almost total transmissions over a broad frequency range can be achieved by use of infinitely anisotropic metamaterials (IAMs). The SPPs are coupled into and out of the bulk modes in the IAMs, where the bulk modes are routed by altering the principle axis of the IAMs...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28451989/tissue-engineered-human-amniotic-membrane-application-in-mouse-ovarian-follicular-culture
#11
M Motamed, Z Sadr, M R Valojerdi, A Moini, S Oryan, M Totonchi, B Ebrahimi, S Maroufizadeh, E Taghiabadi, R Fathi
Since folliculogenesis requires a powerful cell-matrix interaction, natural scaffolds seem to be needed for follicular culture. Human amniotic membrane (HAM) offers promise as a support of in vitro ovarian follicular culture. HAM was decellularized with trypsin and EDTA. DNA and histology assays were performed to determine the elimination rate of genomic components. Cyto-biocompatibility of decellular AM (DAM) was verified by the cell viability (MTT) test. The small parts of intact amniotic membrane (IAM) and DAM were coated on the bottom of 96-well and each well was filled with 150 µL of base medium...
April 27, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28448792/imagining-possible-selves-across-time-characteristics-of-self-images-and-episodic-thoughts
#12
J Hamilton, S N Cole
Thinking about our possible selves can entail thinking about self-related imagined future events. When remembering and imagining, individuals can use both 1st person (field) and 3rd person (observer) perspectives. There is currently a paucity of research examining the visual perspectives of episodic future thoughts that represent possible selves. We hypothesised that temporally distant self-images would elicit more observer perspectives in episodic thoughts than temporally near self-images and current self-images...
April 24, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28435859/the-frequency-and-extent-of-sub-ice-phytoplankton-blooms-in-the-arctic-ocean
#13
Christopher Horvat, David Rees Jones, Sarah Iams, David Schroeder, Daniela Flocco, Daniel Feltham
In July 2011, the observation of a massive phytoplankton bloom underneath a sea ice-covered region of the Chukchi Sea shifted the scientific consensus that regions of the Arctic Ocean covered by sea ice were inhospitable to photosynthetic life. Although the impact of widespread phytoplankton blooms under sea ice on Arctic Ocean ecology and carbon fixation is potentially marked, the prevalence of these events in the modern Arctic and in the recent past is, to date, unknown. We investigate the timing, frequency, and evolution of these events over the past 30 years...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28423343/chitosan-as-coagulant-on-cyanobacteria-in-lake-restoration-management-may-cause-rapid-cell-lysis
#14
Maíra Mucci, Natalia Pessoa Noyma, Leonardo de Magalhães, Marcela Miranda, Frank van Oosterhout, Iamê Alves Guedes, Vera L M Huszar, Marcelo Manzi Marinho, Miquel Lürling
Combining coagulant and ballast to remove cyanobacteria from the water column is a promising restoration technique to mitigate cyanobacterial nuisance in surface waters. The organic, biodegradable polymer chitosan has been promoted as a coagulant and is viewed as non-toxic. In this study, we show that chitosan may rapidly compromise membrane integrity and kill certain cyanobacteria leading to release of cell contents in the water. A strain of Cylindrospermopsis raciborskii and one strain of Planktothrix agardhii were most sensitive...
July 1, 2017: Water Research
https://www.readbyqxmd.com/read/28399367/determination-of-in-vitro-and-in-silico-indexes-for-the-modeling-of-blood-brain-barrier-partitioning-of-drugs-via-micellar-and-immobilized-artificial-membrane-liquid-chromatography
#15
Giacomo Russo, Lucia Grumetto, Roman Szucs, Francesco Barbato, Frederic Lynen
In the present work, 79 structurally unrelated analytes were taken into account and their chromatographic retention coefficients, measured by immobilized artificial membrane liquid chromatography (IAM-LC) and by micellar liquid chromatography (MLC) employing sodium dodecyl sulfate (SDS) as surfactant, were determined. Such indexes, along with topological and physicochemical parameters calculated in silico, were subsequently used for the development of blood-brain barrier passage-predictive statistical models using partial least-squares (PLS) regression...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28369543/sleep-during-pregnancy-the-numom2b-pregnancy-and-sleep-duration-and-continuity-study
#16
Kathryn J Reid, Francesca L Facco, William A Grobman, Corette B Parker, Marcos Herbas, Shannon Hunter, Robert M Silver, Robert C Basner, George R Saade, Grace W Pien, Shalini Manchanda, Judette M Louis, Chia-Lang Nhan-Chang, Judith H Chung, Deborah A Wing, Hyagriv N Simhan, David M Haas, Jay Iams, Samuel Parry, Phyllis C Zee
Study Objectives: To characterize sleep duration, timing and continuity measures in pregnancy and their association with key demographic variables. Methods: Multisite prospective cohort study. Women enrolled in the nuMoM2b study (nulliparous women with a singleton gestation) were recruited at the second study visit (16-21 weeks of gestation) to participate in the Sleep Duration and Continuity substudy. Women <18 years of age or with pregestational diabetes or chronic hypertension were excluded from participation...
May 1, 2017: Sleep
https://www.readbyqxmd.com/read/28362413/assessing-cardiomyocyte-subtypes-following-transcription-factor-mediated-reprogramming-of-mouse-embryonic-fibroblasts
#17
Antonio Fernandez-Perez, Nikhil V Munshi
Direct reprogramming of one cell type into another has recently emerged as a powerful paradigm for regenerative medicine, disease modeling, and lineage specification. In particular, the conversion of fibroblasts into induced cardiomyocyte-like myocytes (iCLMs) by Gata4, Hand2, Mef2c, and Tbx5 (GHMT) represents an important avenue for generating de novo cardiac myocytes in vitro and in vivo. Recent evidence suggests that GHMT generates a greater diversity of cardiac subtypes than previously appreciated, thus underscoring the need for a systematic approach to conducting additional studies...
March 22, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28355631/persistent-illusory-apparent-motion-in-sequences-of-uncorrelated-random-dots
#18
Nicolas Davidenko, Nathan H Heller, Yeram Cheong, Jacob Smith
We report a novel phenomenon in which long sequences of random dot arrays refreshing at 2.5 Hz lead to persistent illusory percepts of coherent apparent motion. We term this effect illusory apparent motion (IAM). To quantify this illusion, we devised a persistence task in which observers are primed with a particular motion pattern and must indicate when the motion pattern ends. In Experiment 1 (N = 119), we induced translational apparent motion patterns and show that both drifting motion (e.g., up-up-up-up) and rebounding motion (e...
March 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28331844/a-single-institution-report-of-19-hepatocellular-carcinoma-patients-with-bile-duct-tumor-thrombus
#19
Anon Chotirosniramit, Akkaphod Liwattanakun, Worakitti Lapisatepun, Wasana Ko-Iam, Trichak Sandhu, Sunhawit Junrungsee
BACKGROUND: Obstructive jaundice caused due to bile duct tumor thrombus (BDTT) in a hepatocellular carcinoma (HCC) patient is an uncommon event. This study reports our clinical experiences and evaluates the outcomes of HCC patients with BDTT in a single institution. METHODS: A retrospective review of 19 HCC patients with secondary obstructive jaundice caused due to BDTT during a 15-year period was conducted. RESULTS: At the time of diagnosis, 14 (73...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28329895/using-a-state-birth-registry-as-a-quality-improvement-tool
#20
Carole Lannon, Heather C Kaplan, Kelly Friar, Sandra Fuller, Susan Ford, Beth White, John Besl, John Paulson, Michael Marcotte, Michael Krew, Jennifer Bailit, Jay Iams
Background Birth registry data are universally collected, generating large administrative datasets. However, these data are typically not used for quality improvement (QI) initiatives in perinatal medicine because the quality and timeliness of the information is uncertain. Objective We sought to identify and address causes of inaccuracy in recording birth registry information so that birth registry data could support statewide obstetrical quality initiatives in Ohio. Study Design The Ohio Perinatal Quality Collaborative and the Ohio Department of Health Vital Statistics used QI techniques in 15 medium-sized maternity hospitals to identify and remove systemic sources of inaccuracy in birth registry data...
March 22, 2017: American Journal of Perinatology
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