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https://www.readbyqxmd.com/read/29157563/nr2f1a-balances-atrial-chamber-and-atrioventricular-canal-size-via-bmp-signaling-independent-and-dependent-mechanisms
#1
Tiffany B Duong, Padmapriyadarshini Ravisankar, Yuntao Charlie Song, Jacob T Gafranek, Ariel B Rydeen, Tracy E Dohn, Lindsey A Barske, J Gage Crump, Joshua S Waxman
Determination of appropriate chamber size is critical for normal vertebrate heart development. Although Nr2f transcription factors promote atrial maintenance and differentiation, how they determine atrial size remains unclear. Here, we demonstrate that zebrafish Nr2f1a is expressed in differentiating atrial cardiomyocytes. Zebrafish nr2f1a mutants have smaller atria due to a specific reduction in atrial cardiomyocyte (AC) number, suggesting it has similar requirements to Nr2f2 in mammals. Furthermore, the smaller atria in nr2f1a mutants are derived from distinct mechanisms that perturb AC differentiation at the chamber poles...
November 17, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29136138/calcific-aortic-valve-stenosis-hard-disease-in-the-heart-a-biomolecular-approach-towards-diagnosis-and-treatment
#2
Frederique E C M Peeters, Steven J R Meex, Marc R Dweck, Elena Aikawa, Harry J G M Crijns, Leon J Schurgers, Bas L J H Kietselaer
Calcific aortic valve stenosis (CAVS) is common in the ageing population and set to become an increasing economic and health burden. Once present, it inevitably progresses and has a poor prognosis in symptomatic patients. No medical therapies are proven to be effective in holding or reducing disease progression. Therefore, aortic valve replacement remains the only available treatment option. Improved knowledge of the mechanisms underlying disease progression has provided us with insights that CAVS is not a passive disease...
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29127894/detection-and-localization-of-copy-paste-forgeries-in-digital-videos
#3
Raahat Devender Singh, Naveen Aggarwal
Amidst the continual march of technology, we find ourselves relying on digital videos to proffer visual evidence in several highly sensitive areas such as journalism, politics, civil and criminal litigation, and military and intelligence operations. However, despite being an indispensable source of information with high evidentiary value, digital videos are also extremely vulnerable to conscious manipulations. Therefore, in a situation where dependence on video evidence is unavoidable, it becomes crucial to authenticate the contents of this evidence before accepting them as an accurate depiction of reality...
October 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29123459/wearable-sensing-of-cardiac-timing-intervals-from-cardiogenic-limb-vibration-signals
#4
Andrew D Wiens, Ann Johnson, Omer T Inan
In this paper we describe a new method to measure aortic valve opening (AVO) and closing (AVC) from cardiogenic limb vibrations (i.e., wearable ballistocardiogram [BCG] signals). AVO and AVC were detected for each heartbeat with accelerometers on the upper arm (A), wrist (W), and knee (K) of 22 subjects following isometric exercise. Exercise-induced changes were recorded with impedance cardiography. The method, Filter BCG, detects peaks in distal vibrations after filtering with individually-tuned bandpass filters...
March 1, 2017: IEEE Sensors Journal
https://www.readbyqxmd.com/read/29096883/influence-of-the-quantity-of-aortic-valve-calcium-on-the-agreement-between-automated-3-dimensional-transesophageal-echocardiography-and-multidetector-row-computed-tomography-for-aortic-annulus-sizing
#5
Tomaz Podlesnikar, Edgard A Prihadi, Philippe J van Rosendael, E Mara Vollema, Frank van der Kley, Arend de Weger, Nina Ajmone Marsan, Franjo Naji, Zlatko Fras, Jeroen J Bax, Victoria Delgado
Accurate aortic annulus sizing is key for selection of appropriate transcatheter aortic valve implantation (TAVI) prosthesis size. The present study compared novel automated 3-dimensional (3D) transesophageal echocardiography (TEE) software and multidetector row computed tomography (MDCT) for aortic annulus sizing and investigated the influence of the quantity of aortic valve calcium (AVC) on the selection of TAVI prosthesis size. A total of 83 patients with severe aortic stenosis undergoing TAVI were evaluated...
October 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29075334/association-of-body-mass-index-and-visceral-fat-with-aortic-valve-calcification-and-mortality-after-transcatheter-aortic-valve-replacement-the-obesity-paradox-in-severe-aortic-stenosis
#6
Jennifer Mancio, Paulo Fonseca, Bruno Figueiredo, Wilson Ferreira, Monica Carvalho, Nuno Ferreira, Pedro Braga, Alberto Rodrigues, Antonio Barros, Ines Falcao-Pires, Adelino Leite-Moreira, Vasco Gama Ribeiro, Nuno Bettencourt
BACKGROUND: Previous studies showed that metabolic syndrome is associated with aortic valve calcification (AVC) and poor outcomes in aortic stenosis (AS). However, if these associations change and how body fat impacts the prognosis of patients in late stage of the disease have been not yet explored. AIMS: To determine the association of body mass index (BMI) and visceral fat with AVC and mortality after transcatheter aortic valve replacement (TAVR). METHODS: This was a prospective cohort of 170 severe AS patients referred to TAVR...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29059940/patient-specific-respiratory-motion-estimation-using-sparse-motion-field-presentation
#7
Dong Chen, Hongzhi Xie, Shuyang Zhang, Weisheng Chen, Lixu Gu
Respiratory motion estimation plays a significant role in radiation therapy. Previous motion estimation approaches usually depended on 4DCT, which introduced extra radio dose for patients, and the local motion details were ignored in the statistical model. In this paper, we propose a novel estimation framework, which employs the Sparse Motion Field Presentation (SMFP) method to obtain a coarse motion estimation which preserves patient-specific respiratory motion details and an Adaptive Variable Coefficient (AVC) motion prior registration approach is applied for the accurate estimation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29040131/acetabular-global-insufficiency-in-patients-with-down-syndrome-and-hip-related-symptoms-a-matched-cohort-study
#8
Evgeny Bulat, Daniel A Maranho, Leslie A Kalish, Michael B Millis, Young-Jo Kim, Eduardo N Novais
BACKGROUND: The etiology of hip instability in Down syndrome is not completely understood. We investigated the morphology of the acetabulum and femur in patients with Down syndrome and compared measurements of the hips with those of matched controls. METHODS: Computed tomography (CT) images of the pelvis of 42 patients with Down syndrome and hip symptoms were compared with those of 42 age and sex-matched subjects without Down syndrome or history of hip disease who had undergone CT for abdominal pain...
October 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29025284/relationship-of-aortic-wall-distensibility-to-mitral-and-aortic-valve-calcification-the-multi-ethnic-study-of-atherosclerosis
#9
Kevin P Cohoon, Michael H Criqui, Matthew J Budoff, Joao A Lima, Michael J Blaha, Paul A Decker, Ramon Durazo, Kiang Liu, Holly Kramer
Data are limited on whether valvular calcification is associated with aortic wall stiffness. We tested whether aortic valve calcification (AVC) and/or mitral valve calcification (MVC) is inversely associated with aortic distensibility (AD). Cross-sectional study conducted in a subset of the Multi-Ethnic Study of Atherosclerosis (MESA) included 3676 MESA participants aged 44 to 84 years with AD measured with magnetic resonance imaging and with AVC and MVC measured with noncontrast cardiac computed tomography scans...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28930258/an-aloe-vera-based-cosmeceutical-cream-delays-and-mitigates-ionizing-radiation-induced-dermatitis-in-head-and-neck-cancer-patients-undergoing-curative-radiotherapy-a-clinical-study
#10
Suresh Rao, Sanath Kumar Hegde, Manjeshwar Poonam Baliga-Rao, Princy Louis Palatty, Thomas George, Manjeshwar Shrinath Baliga
Background: This study was planned to evaluate the efficacy of topical application of an Aloe vera-based cream (AVC) for the prevention of ionizing radiation (X ray)-induced dermatitis in head and neck cancer patients requiring therapeutic radiation treatment (>62 Gy). Methods: From July 2012 to December 2012, a total of 60 head and neck cancer patients requiring curative radiotherapy (RT) of more than 66 Gy were prospectively enrolled and treated with AVC or a comparator Johnson's Baby Oil (JBO). Acute skin reaction was monitored and classified according to the Radiation Therapy Oncology Group (RTOG) four-point rating scale on a weekly basis...
June 24, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28882255/improvement-of-the-performance-of-animal-crossing-warning-signs
#11
Majid Khalilikhah, Kevin Heaslip
INTRODUCTION: Animal-vehicle collisions (AVCs) can result in serious injury and death to drivers, animals' death, and significant economic costs. However, the cost effectiveness of the majority of AVC mitigation measures is a significant issue. METHOD: A mobile-based data collection effort was deployed to measure signs under the Utah Department of Transportation's (UDOT) jurisdiction. The crash data were obtained from the UDOT risk management database. ArcGIS was employed to link these two data sets and extract animal-related crashes and signs...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28803719/assessment-of-aortic-valve-calcium-load-by-multidetector-computed-tomography-anatomical-validation-impact-of-scanner-settings-and-incremental-diagnostic-value
#12
Jamila Boulif, Bernhard Gerber, Alisson Slimani, Siham Lazam, Christophe de Meester, Sophie Piérard, Agnès Pasquet, Anne-Catherine Pouleur, David Vancraeynest, Gébrine El Khoury, Laurent de Kerchove, Philippe Noirhomme, Jean-Louis Vanoverschelde
OBJECTIVES: To validate aortic valve calcium (AVC) load measurements by multidetector row computed tomography (MDCT), to evaluate the impact of tube potential and slice thickness on AVC scores, to examine the accuracy of AVC load in distinguishing severe from nonsevere aortic stenosis (AS) and to investigate its effectiveness as an alternative diagnosis method when echocardiography remains inconclusive. METHODS: We prospectively studied 266 consecutive patients with moderate to severe AS who underwent MDCT to measure AVC load and a comprehensive echocardiographic examination to assess AS severity...
July 29, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28754439/myocardial-blood-flow-reserve-is-impaired-in-patients-with-aortic-valve-calcification-and-unobstructed-epicardial-coronary-arteries
#13
Karen Nel, Michael C Y Nam, Chris Anstey, Christopher J Boos, Edward Carlton, Roxy Senior, Juan Carlos Kaski, Ahmed Khattab, Delva Shamley, Christopher D Byrne, Tony Stanton, Kim Greaves
BACKGROUND: Although calcific aortic valve disease (CAVD) is associated with coronary atherosclerosis, it is not known whether early CAVD is associated with coronary microcirculatory dysfunction (CMD). We sought to investigate the relationship between myocardial blood flow reserve (MBFR) - a measure of CMD, and early CAVD in the absence of obstructive epicardial coronary artery disease. We also determined whether this relationship was independent of coronary artery disease (CAD) and hs-CRP, a marker of systemic inflammation...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28749402/coverage-of-childhood-vaccination-among-children-aged-12-23-months-tamil-nadu-2015-india
#14
Manoj V Murhekar, P Kamaraj, K Kanagasabai, G Elavarasu, T Daniel Rajasekar, K Boopathi, Sanjay Mehendale
BACKGROUND & OBJECTIVES: District-Level Household Survey-4 (DLHS-4) indicated that during 2012-2013, only 56 per cent of children aged 12-23 months in Tamil Nadu were fully vaccinated, which were lesser than those reported in earlier national surveys. We, therefore, conducted cluster surveys to estimate coverage of childhood vaccination in the State, and also to identify the factors associated with low coverage. METHODS: Cross-sectional surveys were conducted in 15 strata [municipal corporation non-slum (n=1), municipal corporation slum (n=1), hilly (n=1), rural (n=6) and urban (n=6)]...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28698175/echocardiographic-aortic-valve-calcification-and-outcomes-in-women-and-men-with-aortic-stenosis
#15
RANDOMIZED CONTROLLED TRIAL
Henrik K Thomassen, Giovanni Cioffi, Eva Gerdts, Eigir Einarsen, Helga Bergljot Midtbø, Costantino Mancusi, Dana Cramariuc
OBJECTIVE: Sex differences in risk factors of aortic valve calcification (AVC) by echocardiography have not been reported from a large prospective study in aortic stenosis (AS). METHODS: AVC was assessed using a prognostically validated visual score and grouped into none/mild or moderate/severe AVC in 1725 men and women with asymptomatic AS in the Simvastatin Ezetimibe in Aortic Stenosis study. The severity of AS was assessed by the energy loss index (ELI) taking pressure recovery in the aortic root into account...
October 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28693246/genetic-alterations-in-japanese-extrahepatic-biliary-tract-cancer
#16
Rei Noguchi, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Yumi Terakado, Yasunori Ohta, Naohide Yamashita, Osamu Kainuma, Sana Yokoi, Yoshiaki Maru, Hiroki Nagase, Yoichi Furukawa
Biliary tract cancer (BTC) is one of the most devastating types of malignant neoplasms worldwide. However, the mechanisms underlying the development and progression of BTC remain unresolved. BTC includes extrahepatic bile duct carcinoma (EBDC), gallbladder carcinoma (GBC) and ampulla of Vater carcinoma (AVC), named according to the location of the tumor. Although genetic alterations of intrahepatic cholangiocarcinoma have been investigated, those of EBDC, GBC and AVC have not yet been fully understood. The present study analyzed somatic mutations of 50 cancer-associated genes in 27 Japanese BTC cells, including: 11 EBDC, 14 GBC and 2 AVC...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28684044/influence-of-metabolic-syndrome-and-diabetes-on-progression-of-calcific-aortic-valve-stenosis
#17
Ariane Testuz, Virginia Nguyen, Tiffany Mathieu, Caroline Kerneis, Dimitri Arangalage, Naozumi Kubota, Isabelle Codogno, Sarah Tubiana, Candice Estellat, Claire Cimadevilla, Alec Vahanian, David Messika-Zeitoun
BACKGROUND: Determinants of the progression of aortic stenosis (AS) remained unclear. Metabolic syndrome (MetS) and diabetes are suspected to play an active role but literature is scarce and results conflicting. We sought to assess their impact in an ongoing prospective cohort of asymptomatic patients with at least mild AS. METHODS: We enrolled 203 patients (73±9years, 75% men) with at least 2years of follow-up. Risk-factors assessment was performed at baseline...
June 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28678926/late-results-of-cox-maze-iii-procedure-in-patients-with-atrial-fibrillation-associated-with-structural-heart-disease
#18
Gustavo Gir Gomes, Wagner Luis Gali, Alvaro Valentim Lima Sarabanda, Claudio Ribeiro da Cunha, Iruena Moraes Kessler, Fernando Antibas Atik
Background: Cox-Maze III procedure is one of the surgical techniques used in the surgical treatment of atrial fibrillation (AF). Objectives: To determine late results of Cox-Maze III in terms of maintenance of sinus rhythm, and mortality and stroke rates. Methods: Between January 2006 and January 2013, 93 patients were submitted to the cut-and-sew Cox-Maze III procedure in combination with structural heart disease repair. Heart rhythm was determined by 24-hour Holter monitoring...
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28649950/quantification-of-aortic-valve-calcification-on-contrast-enhanced-ct-of-patients-prior-to-transcatheter-aortic-valve-implantation
#19
Matthias Eberhard, Monika Mastalerz, Thomas Frauenfelder, Felix C Tanner, Francesco Maisano, Fabian Nietlispach, Burkhardt Seifert, Hatem Alkadhi, Thi Dan Linh Nguyen-Kim
AIMS: To develop a formula enabling the quantification of aortic valve calcification (AVC) on contrast-enhanced CT of patients undergoing transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: 217 consecutive patients with severe aortic valve stenosis undergoing non-enhanced (NECT) and contrast-enhanced electrocardiography-gated CT angiography (CECT) prior to TAVI were subdivided into a training (n=145) and validation cohort (n=72). AVC was semi-automatically segmented on CECT (AVCCE)...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28644212/worsening-atrioventricular-conduction-after-hospital-discharge-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-the-horizons-ami-trial
#20
Ioanna Kosmidou, Björn Redfors, Thomas McAndrew, Monica Embacher, Roxana Mehran, José M Dizon, Ori Ben-Yehuda, Gary S Mintz, Gregg W Stone
BACKGROUND: The chronic effects of ST-segment elevation myocardial infarction (STEMI) on the atrioventricular conduction (AVC) system have not been elucidated. This study aimed to evaluate the incidence, predictors, and outcomes of worsened AVC post-STEMI in patients treated with a primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: The current analysis included patients from the HORIZONS-AMI trial who underwent primary PCI and had available ECGs...
November 2017: Coronary Artery Disease
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