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https://www.readbyqxmd.com/read/27906615/polymorphism-in-exon-6-of-the-human-nt5e-gene-is-associated-with-aortic-valve-calcification
#1
Zdzislaw Kochan, Joanna Karbowska, Patrycja Gogga, Barbara Kutryb-Zajac, Ewa M Slominska, Ryszard T Smolenski
NT5E encodes ecto-5'-nucleotidase (e5NT, CD73) which hydrolyses extracellular AMP to adenosine. Adenosine has been shown to play a protective role against aortic valve calcification (AVC). We identified two nonsynonymous missense single nucleotide polymorphisms (c.1126A > G, p.T376A and c.1136T > C, p.M379T) in exon 6 of the human NT5E gene. Since both substitutions might affect e5NT activity and consequently alter extracellular adenosine levels, we evaluated the association between NT5E alleles and calcific aortic valve disease in 119 patients (95 patients with AVC and 24 controls)...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27890630/arteriovenous-renal-replacement-therapy-in-end-stage-left-sided-heart-failure-patients-has-detrimental-effect-on-patients-with-impaired-right-ventricular-function
#2
Evangelos Repasos, Elisabeth Kaldara, Christos Pantsios, Chris Kapelios, Emmeleia Nana, Spiridon Vernadakis, Christina Melexopoulou, Konstantinos Malliaras, John Boletis, John N Nanas
INTRODUCTION: Chronic intermittent renal replacement therapy(RRT) is an alternate method of decongestion for patients presenting with diuretic-resistant, end-stage heart failure(HF) and cardiorenal syndrome. The optimal method of vascular access has not been confirmed. This study compared the 6-month outcomes of patients with end-stage HF after the creation of arteriovenous communications (AVC) versus other means of RRT. METHODS: We treated 40 patients with chronic, intermittent, ambulatory RRT, of whom 15 (37...
November 23, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27879282/sex-related-discordance-between-aortic-valve-calcification-and-hemodynamic-severity-of-aortic-stenosis-is-valvular-fibrosis-the-explanation
#3
Louis Simard, Nancy Côté, François Dagenais, Patrick Mathieu, Christian Couture, Sylvain Trahan, Yohan Bossé, Siamak Mohammadi, Sylvain Pagé, Philippe Joubert, Marie-Annick Clavel
RATIONALE: Calcific aortic stenosis (AS) is characterized by calcium deposition in valve leaflets. However, women present lower aortic valve calcification (AVC) loads than men for the same AS hemodynamic severity. OBJECTIVE: We thus aimed to assess sex-differences in aortic valve fibro-calcific remodelling. METHODS AND RESULTS: One hundred and twenty-five patients underwent Doppler-echocardiography and multidetector-computed-tomography within 3 months prior to aortic valve replacement...
November 22, 2016: Circulation Research
https://www.readbyqxmd.com/read/27878217/factors-associated-with-young-adults-knowledge-regarding-family-history-of-stroke
#4
Maria Jose Melo Ramos Lima, Thereza Maria Magalhães Moreira, Raquel Sampaio Florêncio, Predro Braga
Objective: to analyze the factors associated with young adults' knowledge regarding family history of stroke. Method: an analytical transversal study, with 579 young adults from state schools, with collection of sociodemographic, clinical and risk factor-related variables, analyzed using logistic regression (backward elimination). Results: a statistical association was detected between age, civil status, and classification of arterial blood pressure and abdominal circumference with knowledge of family history of stroke...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27793704/influence-of-bioadhesive-polymers-on-the-protective-effect-of-fluoride-against-erosion
#5
Daniele Mara da Silva Ávila, Rayssa Ferreira Zanatta, Tais Scaramucci, Idalina Vieira Aoki, Carlos Rocha Gomes Torres, Alessandra Bühler Borges
OBJECTIVE: This study investigated if the incorporation of the bioadhesive polymers Carbopol 980, Carboxymethyl cellulose (CMC), and Aristoflex AVC in a fluoridated solution (NaF-900ppm) would increase the solution's protective effect against enamel erosion. METHODS: Enamel specimens were submitted to a 5-day de-remineralization cycling model, consisting of 2min immersions in 0.3% citric acid (6x/day), 1min treatments with the polymers (associated or not with fluoride), and 60min storage in artificial saliva...
October 25, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27767996/aortic-valve-calcification-and-the-risk-of-dementia-a-population-based-study
#6
Frank J Wolters, Daniel Bos, Meike W Vernooij, Oscar H Franco, Albert Hofman, Peter J Koudstaal, Aad van der Lugt, M Arfan Ikram
The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0...
October 20, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27752518/automated-voxel-classification-used-with-atlas-guided-diffuse-optical-tomography-for-assessment-of-functional-brain-networks-in-young-and-older-adults
#7
Lin Li, Mary Cazzell, Olajide Babawale, Hanli Liu
Atlas-guided diffuse optical tomography (atlas-DOT) is a computational means to image changes in cortical hemodynamic signals during human brain activities. Graph theory analysis (GTA) is a network analysis tool commonly used in functional neuroimaging to study brain networks. Atlas-DOT has not been analyzed with GTA to derive large-scale brain connectivity/networks based on near-infrared spectroscopy (NIRS) measurements. We introduced an automated voxel classification (AVC) method that facilitated the use of GTA with atlas-DOT images by grouping unequal-sized finite element voxels into anatomically meaningful regions of interest within the human brain...
October 2016: Neurophotonics
https://www.readbyqxmd.com/read/27738235/aortic-valve-calcification-and-risk-of-stroke-the-rotterdam-study
#8
Daniel Bos, Atefeh Bozorgpourniazi, Unal Mutlu, Maryam Kavousi, Meike W Vernooij, Adriaan Moelker, Oscar H Franco, Peter J Koudstaal, M Arfan Ikram, Aad van der Lugt
BACKGROUND AND PURPOSE: It remains uncertain whether aortic valve calcification (AVC) is a risk factor for stroke. METHODS: From the population-based Rotterdam Study, 2471 participants (mean age: 69.6 years; 51.8% women) underwent computed tomography to quantify AVC. We assessed prevalent stroke and continuously monitored the remaining participants for the incidence of stroke. Logistic and Cox regression models were used to investigate associations of AVC with prevalent stroke and risk of incident stroke...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27733929/cardiac-ultrasonography-over-4g-wireless-networks-using-a-tele-operated-robot
#9
Sotiris Avgousti, Andreas S Panayides, Antonis P Jossif, Eftychios G Christoforou, Pierre Vieyres, Cyril Novales, Sotos Voskarides, Constantinos S Pattichis
This Letter proposes an end-to-end mobile tele-echography platform using a portable robot for remote cardiac ultrasonography. Performance evaluation investigates the capacity of long-term evolution (LTE) wireless networks to facilitate responsive robot tele-manipulation and real-time ultrasound video streaming that qualifies for clinical practice. Within this context, a thorough video coding standards comparison for cardiac ultrasound applications is performed, using a data set of ten ultrasound videos. Both objective and subjective (clinical) video quality assessment demonstrate that H...
September 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27733732/predictive-value-of-aortic-valve-calcification-for-periprocedural-myocardial-injury-in-patients-undergoing-percutaneous-coronary-intervention
#10
Yohei Shibata, Hideki Ishii, Susumu Suzuki, Akihito Tanaka, Yosuke Tatami, Shingo Harata, Tomoyuki Ota, Yusaku Shimbo, Yohei Takayama, Ayako Kunimura, Kenshi Hirayama, Kazuhiro Harada, Naohiro Osugi, Toyoaki Murohara
AIMS: Previous studies have shown that aortic valve calcification (AVC) was associated with cardiovascular events and mortality. On the other hand, periprocedural myocardial injury (PMI) in percutaneous coronary intervention (PCI) is a well-known predictor of subsequent mortality and poor clinical outcomes. The purpose of the study was to assess the hypothesis that the presence of AVC could predict PMI in PCI. METHODS: This study included 370 patients treated with PCI for stable angina pectoris...
October 13, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27681732/real-time-performance-of-mechatronic-pzt-module-using-active-vibration-feedback-control
#11
Francesco Aggogeri, Alberto Borboni, Angelo Merlo, Nicola Pellegrini, Raffaele Ricatto
This paper proposes an innovative mechatronic piezo-actuated module to control vibrations in modern machine tools. Vibrations represent one of the main issues that seriously compromise the quality of the workpiece. The active vibration control (AVC) device is composed of a host part integrated with sensors and actuators synchronized by a regulator; it is able to make a self-assessment and adjust to alterations in the environment. In particular, an innovative smart actuator has been designed and developed to satisfy machining requirements during active vibration control...
2016: Sensors
https://www.readbyqxmd.com/read/27612848/paravalvular-leak-after-transcatheter-aortic-valve-implantation-is-it-anatomically-predictable-or-procedurally-determined-mdct-study
#12
A A Sakrana, M M Nasr, G A Ashamallah, R A Abuelatta, H A Naeim, M E Tahlawi
AIM: To investigate the determinants of paravalvular leak (PVL) occurring after transcatheter aortic valve implantation (TAVI). MATERIALS AND METHODS: One hundred and eight patients with severe symptomatic aortic stenosis (mean age 75.5±11.8 years, 72.2% male) underwent contrast-enhanced electrocardiogram (ECG)-gated multidetector computed tomography (MDCT) then successful TAVI. The following parameters were determined in the late systolic phase: annular and left ventricular outflow tract (LVOT) diameters, annular perimeter, ellipticity index, annular area, indexed annular area, LVOT perimeter, annulus/LVOT perimeter difference ratio, the LVOT to ascending aorta angle (< LVOT-AO)...
November 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27611608/ampulla-of-vater-carcinoma-sequencing-analysis-identifies-tp53-status-as-a-novel-independent-prognostic-factor-and-potentially-actionable-erbb-pi3k-and-wnt-pathways-gene-mutations
#13
Andrea Mafficini, Eliana Amato, Ivana Cataldo, Borislav C Rusev, Luca Bertoncello, Vincenzo Corbo, Michele Simbolo, Claudio Luchini, Matteo Fassan, Cinzia Cantù, Roberto Salvia, Giovanni Marchegiani, Giampaolo Tortora, Rita T Lawlor, Claudio Bassi, Aldo Scarpa
OBJECTIVE: To identify molecular prognostic factors and potentially actionable mutations in ampulla of Vater cancer (AVC). BACKGROUND: The largely variable outcomes of AVCs make clinical decisions difficult regarding the need of postsurgical therapy, which is based on morphological and immunohistochemical classification that do not adequately consider the varying degrees of heterogeneity present in many AVCs. No approved targeted therapies for AVC exist, but some show promising results requiring better molecular characterization to identify potential responders...
September 8, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27597530/influence-of-aortic-valve-leaflet-calcification-on-dynamic-aortic-valve-motion-assessed-by-cardiac-computed-tomography
#14
Keisuke Minami, Kihei Yoneyama, Masaki Izumo, Kengo Suzuki, Yasuyoshi Ogawa, Kousuke Chikaraishi, Yukihisa Ogawa, Yasuyuki Kobayashi, Toshiyuki Furukawa, Yasuhiro Tanabe, Yoshihiro J Akashi
BACKGROUND: Computed tomography is the best noninvasive imaging modality for evaluating valve leaflet calcification. OBJECTIVE: To evaluate the association of aortic valve leaflet calcification with instantaneous valve opening and closing using dynamic multidetector computed tomography (MDCT). METHODS: We retrospectively evaluated 58 consecutive patients who underwent dynamic MDCT imaging. Aortic valve calcification (AVC) was quantified using the Agatston method...
August 23, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27560017/aortic-valve-and-thoracic-aortic-calcification-measurements-how-low-can-we-go-in-radiation-dose
#15
Robbert Willem van Hamersvelt, Annemarie M den Harder, Martin J Willemink, Arnold M R Schilham, Jan-Willem J Lammers, Hendrik M Nathoe, Ricardo P J Budde, Tim Leiner, Pim A de Jong
OBJECTIVE: This study aimed to determine the lowest radiation dose and iterative reconstruction level(s) at which computed tomography (CT)-based quantification of aortic valve calcification (AVC) and thoracic aortic calcification (TAC) is still feasible. METHODS: Twenty-eight patients underwent a cardiac CT and 20 patients a chest CT at 4 different dose levels (routine dose and approximately 40%, 60%, and 80% reduced dose). Data were reconstructed with filtered back projection, 3 iDose levels, and 3 iterative model-based reconstruction levels...
August 25, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27556898/embryonic-ethanol-exposure-dysregulates-bmp-and-notch-signaling-leading-to-persistent-atrio-ventricular-valve-defects-in-zebrafish
#16
Swapnalee Sarmah, Pooja Muralidharan, James A Marrs
Fetal alcohol spectrum disorder (FASD), birth defects associated with ethanol exposure in utero, includes a wide spectrum of congenital heart defects (CHDs), the most prevalent of which are septal and conotruncal defects. Zebrafish FASD model was used to dissect the mechanisms underlying FASD-associated CHDs. Embryonic ethanol exposure (3-24 hours post fertilization) led to defects in atrio-ventricular (AV) valvulogenesis beginning around 37 hpf, a morphogenetic event that arises long after ethanol withdrawal...
2016: PloS One
https://www.readbyqxmd.com/read/27533256/stroke-prevention-in-atrial-fibrillation-focus-on-latin-america
#17
Ayrton R Massaro, Gregory Y H Lippp
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with an estimated prevalence of 1-2% in North America and Europe. The increased prevalence of AF in Latin America is associated with an ageing general population, along with poor control of key risk factors, including hypertension. As a result, stroke prevalence and associated mortality have increased dramatically in the region. Therefore, the need for effective anticoagulation strategies in Latin America is clear. The aim of this review is to provide a contemporary overview of anticoagulants for stroke prevention...
August 11, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27521222/relation-between-epicardial-adipose-and-aortic-valve-and-mitral-annular-calcium-determined-by-computed-tomography-in-subjects-aged-%C3%A2-65%C3%A2-years
#18
Talal S Alnabelsi, Yaser Alhamshari, Ramzi H Mulki, Jose N Codolosa, Nikoloz Koshkelashvili, Igor Goykhman, Gregg S Pressman, Abel Romero-Corral
Epicardial adipose tissue (EAT) has been linked to coronary artery calcium deposits and atherosclerotic disease. Mitral annular (MAC) and aortic valve calcium (AVC) have also been associated with atherosclerosis. This study examined the possible relation between EAT thickness and valvular calcium deposits. We included 294 patients aged ≥65 years who had noncontrast computed tomography scans of the chest. Mean age was 76 ± 7 years; 47% were men. Using reconstructed images, EAT thickness was measured at various locations...
October 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27511597/mechanisms-influencing-retrograde-flow-in-the-atrioventricular-canal-during-early-embryonic-cardiogenesis
#19
Alexander Bulk, David Bark, Brennan Johnson, Deborah Garrity, Lakshmi Prasad Dasi
Normal development of the heart is regulated, in part, by mechanical influences associated with blood flow during early stages of embryogenesis. Specifically, the potential for retrograde flow at the atrioventricular canal (AVC) is particularly important in valve development. However, the mechanisms causing this retrograde flow have received little attention. In this study, a numerical analysis was performed on images of the embryonic zebrafish heart between 48 and 55hpf. During these stages, normal retrograde flow is prevalent...
October 3, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27508688/-op-4a-03-is-white-coat-effect-protective-for-the-prognosis-of-cardiovascular-events
#20
J Bastos, A Araújo, J Pires, J Pinto, P Almeida, J Polonia
OBJECTIVE: HASH(0x41f6c68) AIM: It is not well known if systolic white coat effect (WCE), the difference between casual systolic blood pressure (SBPc) and daytime systolic blood pressure determined by ambulatory blood pressure (ABPM), is a marker or not of worst cardiovascular events (CV).The aim of the study was to evaluate the prognostic value of white coat effect in relation to cardiovascular events (CV) stroke (AVC) and coronary events (DC). DESIGN AND METHOD: Casual and ABP were obtained in 1200 hypertensive patients (645 female) age 51 ± 12 years, BMI 27 ± 5 Kg/m2, SBPc 154...
September 2016: Journal of Hypertension
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