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https://www.readbyqxmd.com/read/28698175/echocardiographic-aortic-valve-calcification-and-outcomes-in-women-and-men-with-aortic-stenosis
#1
Henrik K Thomassen, Giovanni Cioffi, Eva Gerdts, Eigir Einarsen, Helga Bergljot Midtbø, Constantino Mancusi, Dana Cramariuc
OBJECTIVE: Sex differences in risk factors of aortic valve calcification (AVC) by echocardiography have not been reported from a large prospective study in aortic stenosis (AS). METHODS: AVC was assessed using a prognostically validated visual score and grouped into none/mild or moderate/severe AVC in 1725 men and women with asymptomatic AS in the Simvastatin Ezetimibe in Aortic Stenosis study. The severity of AS was assessed by the energy loss index (ELI) taking pressure recovery in the aortic root into account...
July 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28693246/genetic-alterations-in-japanese-extrahepatic-biliary-tract-cancer
#2
Rei Noguchi, Kiyoshi Yamaguchi, Tsuneo Ikenoue, Yumi Terakado, Yasunori Ohta, Naohide Yamashita, Osamu Kainuma, Sana Yokoi, Yoshiaki Maru, Hiroki Nagase, Yoichi Furukawa
Biliary tract cancer (BTC) is one of the most devastating types of malignant neoplasms worldwide. However, the mechanisms underlying the development and progression of BTC remain unresolved. BTC includes extrahepatic bile duct carcinoma (EBDC), gallbladder carcinoma (GBC) and ampulla of Vater carcinoma (AVC), named according to the location of the tumor. Although genetic alterations of intrahepatic cholangiocarcinoma have been investigated, those of EBDC, GBC and AVC have not yet been fully understood. The present study analyzed somatic mutations of 50 cancer-associated genes in 27 Japanese BTC cells, including: 11 EBDC, 14 GBC and 2 AVC...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28684044/influence-of-metabolic-syndrome-and-diabetes-on-progression-of-calcific-aortic-valve-stenosis
#3
Ariane Testuz, Virginia Nguyen, Tiffany Mathieu, Caroline Kerneis, Dimitri Arangalage, Naozumi Kubota, Isabelle Codogno, Sarah Tubiana, Candice Estellat, Claire Cimadevilla, Alec Vahanian, David Messika-Zeitoun
BACKGROUND: Determinants of the progression of aortic stenosis (AS) remained unclear. Metabolic syndrome (MetS) and diabetes are suspected to play an active role but literature is scarce and results conflicting. We sought to assess their impact in an ongoing prospective cohort of asymptomatic patients with at least mild AS. METHODS: We enrolled 203 patients (73±9years, 75% men) with at least 2years of follow-up. Risk-factors assessment was performed at baseline...
June 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28678926/late-results-of-cox-maze-iii-procedure-in-patients-with-atrial-fibrillation-associated-with-structural-heart-disease
#4
Gustavo Gir Gomes, Wagner Luis Gali, Alvaro Valentim Lima Sarabanda, Claudio Ribeiro da Cunha, Iruena Moraes Kessler, Fernando Antibas Atik
Background: Cox-Maze III procedure is one of the surgical techniques used in the surgical treatment of atrial fibrillation (AF). Objectives: To determine late results of Cox-Maze III in terms of maintenance of sinus rhythm, and mortality and stroke rates. Methods: Between January 2006 and January 2013, 93 patients were submitted to the cut-and-sew Cox-Maze III procedure in combination with structural heart disease repair. Heart rhythm was determined by 24-hour Holter monitoring...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28649950/quantification-of-aortic-valve-calcification-on-contrast-enhanced-ct-of-patients-prior-to-transcatheter-aortic-valve-implantation
#5
Matthias Eberhar, Monika Mastalerz, Thomas Frauenfelder, Felix C Tanner, Francesco Maisano, Fabian Nietlispach, Burkhardt Seifert, Hatem Alkadhi, Thi Dan Linh Nguyen-Kim
AIMS: To develop a formula enabling the quantification of aortic valve calcification (AVC) on contrast-enhanced CT of patients undergoing transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: 217 consecutive patients with severe aortic valve stenosis undergoing non-enhanced (NECT) and contrast-enhanced electrocardiography-gated CT angiography (CECT) prior to TAVI were subdivided into a training (n=145) and validation cohort (n=72). AVC was semi-automatically segmented on CECT (AVCCE)...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28644212/worsening-atrioventricular-conduction-after-hospital-discharge-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-the-horizons-ami-trial
#6
Ioanna Kosmidou, Björn Redfors, Thomas McAndrew, Monica Embacher, Roxana Mehran, José M Dizon, Ori Ben-Yehuda, Gary S Mintz, Gregg W Stone
BACKGROUND: The chronic effects of ST-segment elevation myocardial infarction (STEMI) on the atrioventricular conduction (AVC) system have not been elucidated. This study aimed to evaluate the incidence, predictors, and outcomes of worsened AVC post-STEMI in patients treated with a primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: The current analysis included patients from the HORIZONS-AMI trial who underwent primary PCI and had available ECGs...
June 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28637586/soluble-lr11-associates-with-aortic-root-calcification-in-asymptomatic-treated-male-patients-with-familial-hypercholesterolemia
#7
Ranitha Vongpromek, Sven Bos, Gert-Jan R Ten Kate, Hideaki Bujo, Meizi Jiang, Koen Nieman, Wolfgang Schneider, Jeanine E Roeters van Lennep, Adrie J M Verhoeven, Eric J G Sijbrands, Monique T Mulder
BACKGROUND AND AIMS: Despite statin treatment, a high prevalence of severe vascular calcification is found in patients with familial hypercholesterolemia (FH). We assessed the relation between the circulating soluble form of low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11), a risk factor for cardiovascular disease, and vascular calcification in asymptomatic statin-treated heterozygous FH patients. METHODS: In 123 asymptomatic heterozygous FH patients (age 40-69 years), aortic root (ARC), aortic valve (AVC) and coronary artery calcification (CAC) were determined with CT-based calcium scoring expressed in Agatston units...
June 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28583687/relation-of-serum-vitamin-d-to-risk-of-mitral-annular-and-aortic-valve-calcium-from-the-multi-ethnic-study-of-atherosclerosis
#8
Martin Tibuakuu, Di Zhao, Ian H de Boer, Eliseo Guallar, Anna E Bortnick, Pamela L Lutsey, Matthew J Budoff, Jorge R Kizer, Bryan R Kestenbaum, Erin D Michos
Serum 25-hydroxyvitamin D [25(OH)D] concentration has been identified as a possible modifiable risk factor for cardiovascular disease (CVD). We hypothesized that serum 25(OH)D concentration would be associated with calcifications of the left-sided heart valves, which are markers of CVD risk. Aortic valve calcium (AVC) and mitral annular calcium (MAC) were quantified from cardiac computed tomography scans performed on 5,530 Multi-Ethnic Study of Atherosclerosis participants at the baseline examination (2000 to 2002) and at a follow-up visit at either Examination 2 (2002 to 2004) or Examination 3 (2004 to 2005)...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28562816/influence-of-hormonal-contraceptives-and-the-occurrence-of-stroke-integrative-review
#9
Adman Câmara Soares Lima, Larissa Castelo Guedes Martins, Marcos Venícios de Oliveira Lopes, Thelma Leite de Araújo, Francisca Elisângela Teixeira Lima, Priscila de Souza Aquino, Escolástica Rejane Ferreira Moura
Objective: To identify scientific evidence regarding the influence of hormonal contraceptive use and the occurrence of stroke. Method: Integrative review of the literature, through database search using the descriptors "contraceptive agents", "contraceptive devices", "contraceptives, Oral" and "Stroke". Original studies in Portuguese, Spanish and English, published in full and available online were included. Studies that did not answer our guiding questions and duplicated studies were excluded...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28560501/relationship-of-bone-mineral-density-with-valvular-and-annular-calcification-in-community-dwelling-older-people-the-cardiovascular-health-study
#10
Daniele Massera, Shuo Xu, Traci M Bartz, Anna E Bortnick, Joachim H Ix, Michel Chonchol, David S Owens, Eddy Barasch, Julius M Gardin, John S Gottdiener, John R Robbins, David S Siscovick, Jorge R Kizer
Associations between bone mineral density and aortic valvular, aortic annular, and mitral annular calcification were investigated in a cross-sectional analysis of a population-based cohort of 1497 older adults. Although there was no association between continuous bone mineral density and outcomes, a significant association between osteoporosis and aortic valvular calcification in men was found. INTRODUCTION: The process of cardiac calcification bears a resemblance to skeletal bone metabolism and its regulation...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28538179/hand2-target-gene-regulatory-networks-control-atrioventricular-canal-and-cardiac-valve-development
#11
Frédéric Laurent, Ausra Girdziusaite, Julie Gamart, Iros Barozzi, Marco Osterwalder, Jennifer A Akiyama, Joy Lincoln, Javier Lopez-Rios, Axel Visel, Aimée Zuniga, Rolf Zeller
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essential functions in the endothelial to mesenchymal transition (EMT) underlying cardiac cushion development in the atrioventricular canal (AVC). In Hand2-deficient mouse embryos, the EMT underlying AVC cardiac cushion formation is disrupted, and we combined ChIP-seq of embryonic hearts with transcriptome analysis of wild-type and mutants AVCs to identify the functionally relevant HAND2 target genes. The HAND2 target gene regulatory network (GRN) includes most genes with known functions in EMT processes and AVC cardiac cushion formation...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28497044/predicting-the-types-of-ion-channel-targeted-conotoxins-based-on-avc-svm-model
#12
Wang Xianfang, Wang Junmei, Wang Xiaolei, Zhang Yue
The conotoxin proteins are disulfide-rich small peptides. Predicting the types of ion channel-targeted conotoxins has great value in the treatment of chronic diseases, epilepsy, and cardiovascular diseases. To solve the problem of information redundancy existing when using current methods, a new model is presented to predict the types of ion channel-targeted conotoxins based on AVC (Analysis of Variance and Correlation) and SVM (Support Vector Machine). First, the F value is used to measure the significance level of the feature for the result, and the attribute with smaller F value is filtered by rough selection...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28444887/morphological-study-of-the-atrioventricular-conduction-system-and-purkinje-fibers-in-yak
#13
Deyong Duan, Sijiu Yu, Yan Cui, Chaoxu Li
We studied the morphology of the atrioventricular conduction system (AVCS) and Purkinje fibers of the yak. Light and transmission electron microscopy were used to study the histological features of AVCS. The distributional characteristics of the His-bundle, the left bundle branch (LBB), right bundle branch (RBB), and Purkinje fiber network of yak hearts were examined using gross dissection, ink injection, and ABS casting. The results showed that the atrioventricular node (AVN) of yak located in the right side of interatrial septum and had a flattened ovoid shape...
July 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28422683/progressive-dictionary-learning-with-hierarchical-predictive-structure-for-scalable-video-coding
#14
Wenrui Dai, Yangmei Shen, Hongkai Xiong, Xiaoqian Jiang, Junni Zou, David Taubman
Dictionary learning has emerged as a promising alternative to the conventional hybrid coding framework. However, the rigid structure of sequential training and prediction degrades its performance in scalable video coding. This paper proposes a progressive dictionary learning framework with hierarchical predictive structure for scalable video coding, especially in low bitrate region. For pyramidal layers, sparse representation based on spatio-temporal dictionary is adopted to improve the coding efficiency of enhancement layers (ELs) with a guarantee of reconstruction performance...
April 12, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28415102/p650influence-of-fetunin-a-level-on-progression-of-calcific-aortic-valve-stenosis-the-cofrasa-generac-study
#15
N Kubota, Dmz David Messika-Zeitoun
Background.: In recent years, pathophysiology of aortic stenosis (AS) has been considered as a possibly active inflammatory process, but its determinants remain unclear. Calcium tissue deposition observed in dilaysis patients have been linked to low level of Fetuin-A, a powerful inhibitor of ectopic calcification. It is thus suspected to play a role in development of aortic stenosis. Purpose.: To assess correlation between Fetuin-A level and AS progression in a prospective cohort of AS patients, COFRASA (clinicalTrial...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28412434/a-highly-predictive-risk-model-for-pacemaker-implantation-after-tavr
#16
Yoshio Maeno, Yigal Abramowitz, Hiroyuki Kawamori, Yoshio Kazuno, Shunsuke Kubo, Nobuyuki Takahashi, Geeteshwar Mangat, Kazuaki Okuyama, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, John Friedman, Daniel Berman, Raj R Makkar, Hasan Jilaihawi
OBJECTIVES: This study sought to develop a robust and definitive risk model for new permanent pacemaker implantation (PPMI) after SAPIEN 3 (third generation balloon expandable valve) (Edwards Lifesciences, Irvine, California) transcatheter aortic valve replacement (third generation balloon expandable valve TAVR), including calcification in the aortic-valvular complex (AVC). BACKGROUND: The association between calcium in the AVC and need for PPMI is poorly delineated after third generation balloon expandable valve TAVR...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28379569/one-health-pathogens-in-the-aspergillus-viridinutans-complex
#17
Jessica J Talbot, Vanessa R Barrs
Cryptic species in Aspergillus section Fumigati are increasingly recognised as pathogens in humans and animals. The A. viridinutans complex (AVC) has recently expanded to comprise 10 species, of which six are known to be pathogenic, including A. udagawae, A. felis, A. pseudofelis, A. parafelis, A. pseudoviridinutans, and A. wyomingensis. They cause locally invasive and disseminated invasive disease syndromes, including chronic pulmonary aspergillosis and invasive aspergillosis in humans, invasive fungal rhinosinusitis in cats, and disseminated invasive aspergillosis in dogs...
March 31, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28369223/severe-aortic-stenosis-with-low-aortic-valve-calcification-characteristics-and-outcome-following-transcatheter-aortic-valve-implantation
#18
Yigal Abramowitz, Hasan Jilaihawi, Philippe Pibarot, Tarun Chakravarty, Mohammad Kashif, Yoshio Kazuno, Yoshio Maeno, Hiroyuki Kawamori, Geeteshwar Mangat, John Friedman, Wen Cheng, Raj R Makkar
Aims: High aortic valve calcification (AVC) assessed with CT may be used to differentiate between severe and non-severe aortic stenosis (AS). Nonetheless, in some cases patients with low calcification are diagnosed with haemodynamically severe AS. The prevalence, mechanism of valve stenosis and implications for transcatheter aortic valve implantation (TAVI) of low AVC severe AS remain unclear. We assessed the clinical and haemodynamic characteristics and the outcome of patients with severe AS and low AVC that undergo TAVI...
June 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28361689/avc-selecting-discriminative-features-on-basis-of-auc-by-maximizing-variable-complementarity
#19
Lei Sun, Jun Wang, Jinmao Wei
BACKGROUND: The Receiver Operator Characteristic (ROC) curve is well-known in evaluating classification performance in biomedical field. Owing to its superiority in dealing with imbalanced and cost-sensitive data, the ROC curve has been exploited as a popular metric to evaluate and find out disease-related genes (features). The existing ROC-based feature selection approaches are simple and effective in evaluating individual features. However, these approaches may fail to find real target feature subset due to their lack of effective means to reduce the redundancy between features, which is essential in machine learning...
March 14, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28303655/cholangiohepatitis-in-dairy-cattle-13-cases
#20
D E Gomez, E Doré, D Francoz, A Desrochers, H Pierre, G Fecteau
BACKGROUND: The signalment, clinicopathologic, bacteriological, histopathological, ultrasonographic characteristics, and the treatment and outcomes of adult cattle with cholangiohepatitis are poorly defined. ANIMALS: Thirteen Holstein cows with cholangiohepatitis. METHODS: Retrospective study of medical records of cattle admitted to the CHUV and the AVC between 1992 and 2012 and 2000 and 2012, respectively, for cattle older than 3 months of age with a histopathological diagnosis of cholangiohepatitis...
May 2017: Journal of Veterinary Internal Medicine
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