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https://www.readbyqxmd.com/read/29756589/effect-of-combination-therapy-with-neuroprotective-and-vasoprotective-agents-on-cerebral-ischemia
#1
Jiping Yang, Bei Yang, Baoxin Xiu, Jinchong Qi, Huaijun Liu
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. METHODS: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29752386/nppa-and-nppb-act-redundantly-during-zebrafish-cardiac-development-to-confine-avc-marker-expression-and-reduce-cardiac-jelly-volume
#2
Daniela R Grassini, Anne K Lagendijk, Jessica E De Angelis, Jason Da Silva, Angela Jeanes, Nicole Zettler, Neil I Bower, Benjamin M Hogan, Kelly A Smith
Atrial natriuretic peptide ( nppa/anf ) and brain natriuretic peptide ( nppb/bnp ) form a gene cluster with expression in the chambers of the developing heart. Despite restricted expression, a function in cardiac development has not been demonstrated by mutant analysis. This is attributed to functional redundancy however their genomic location in cis has impeded formal analysis. Using genome-editing, we generated mutants for nppa and nppb and found single mutants indistinguishable from wildtype whereas nppa / nppb double mutants display heart morphogenesis defects and pericardial oedema...
May 11, 2018: Development
https://www.readbyqxmd.com/read/29731265/mir-21-up-regulation-in-ampullary-adenocarcinoma-and-its-pre-invasive-lesions
#3
Deborah Saraggi, Francesca Galuppini, Giuseppe N Fanelli, Andrea Remo, Emanuele D L Urso, Ricardo Q Bao, Deborah Bacchin, Vincenza Guzzardo, Claudio Luchini, Chiara Braconi, Fabio Farinati, Massimo Rugge, Matteo Fassan
Poor information is available on the molecular landscape characterizing the carcinogenetic process leading to ampullary carcinoma. MiR-21 is one of the most frequently up-regulated miRNAs in pancreatic adenocarcinoma, a tumor sharing similar molecular features with ampullary adenocarcinomas (AVCs), above all with the pancreatic-biliary type. We profiled, by in situ hybridization (ISH), miR-21 expression in a series of 26 AVCs, 50 ampullary dysplastic lesions (35 low-grade [LG-IEN] and 15 high-grade [HG-IEN]) and 10 normal duodenal mucosa samples...
May 1, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29698212/residual-highway-convolutional-neural-networks-for-in-loop-filtering-in-hevc
#4
Yongbing Zhang, Tao Shen, Xiangyang Ji, Yun Zhang, Ruiqin Xiong, Qionghai Dai
High efficiency video coding (HEVC) standard achieves half bit-rate reduction while keeping the same quality compared with AVC. However, it still cannot satisfy the demand of higher quality in real applications, especially at low bit rates. To further improve the quality of reconstructed frame while reducing the bitrates, a residual highway convolutional neural network (RHCNN) is proposed in this paper for in-loop filtering in HEVC. The RHCNN is composed of several residual highway units and convolutional layers...
August 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29677630/resting-heart-rate-and-the-incidence-and-progression-of-valvular-calcium-the-multi-ethnic-study-of-atherosclerosis-mesa
#5
Kojo Amoakwa, Oluwaseun E Fashanu, Martin Tibuakuu, Di Zhao, Eliseo Guallar, Seamus P Whelton, Wesley T O'Neal, Wendy S Post, Matthew J Budoff, Erin D Michos
BACKGROUND AND AIMS: Left-sided valvular calcification is associated with cardiovascular disease (CVD) morbidity and mortality. Resting heart rate (RHR) may influence valvular calcium progression through shear stress. Whether RHR, an established CVD risk factor, is associated with valvular calcium progression is unknown. We assessed whether RHR predicts incidence and progression of mitral annular calcium (MAC) and aortic valve calcium (AVC) in a community-based cohort free of CVD at baseline...
April 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29667013/predictors-of-paravalvular-regurgitation-and-permanent-pacemaker-implantation-after-tavr-with-a-next-generation-self-expanding-device
#6
Victor Mauri, Florian Deuschl, Thomas Frohn, Niklas Schofer, Matthias Linder, Elmar Kuhn, Andreas Schaefer, Volker Rudolph, Navid Madershahian, Lenard Conradi, Tanja K Rudolph, Ulrich Schäfer
AIMS: To identify predictors of paravalvular regurgitation (PVR) and permanent pacemaker implantation (PPI) following TAVR with a next-generation self-expanding device. METHODS AND RESULTS: Device landing zone (DLZ) calcification, angiographic implantation depth, and baseline and procedural characteristics were analyzed in 212 patients being treated with the ACURATE neo aortic bioprosthesis. PVR was none/trace in 57.1% and ≥ mild in 42.9% (37% mild, 6% moderate)...
April 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29656781/observational-and-genetic-associations-of-resting-heart-rate-with-aortic-valve-calcium
#7
Seamus P Whelton, Andreas C Mauer, Karol M Pencina, Joseph M Massaro, Ralph B D'Agostino, Caroline S Fox, Udo Hoffmann, Erin D Michos, Gina M Peloso, Line Dufresne, James C Engert, Sekar Kathiresan, Matthew Budoff, Wendy S Post, George Thanassoulis, Christopher J O'Donnell
It is unknown if lifelong exposure to increased hemodynamic stress from an elevated resting heart rate (HR) may contribute to aortic valve calcium (AVC). We performed multivariate regression analyses using data from 1,266 Framingham Heart Study (FHS) Offspring cohort participants and 6,764 Multi-Ethnic Study of Atherosclerosis (MESA) participants. We constructed a genetic risk score (GRS) for HR using summary-level data in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) AVC Consortium to investigate if there was evidence in favor of a causal relation...
February 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29655832/serum-magnesium-phosphorus-and-calcium-levels-and-subclinical-calcific-aortic-valve-disease-a-population-based-study
#8
Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima
BACKGROUND AND AIMS: Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). METHODS: We conducted a prospective study in a population-based sample of Japanese men aged 40-79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method...
March 22, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29555836/computed-tomography-aortic-valve-calcium-scoring-in-patients-with-aortic-stenosis
#9
Tania Pawade, Marie-Annick Clavel, Christophe Tribouilloy, Julien Dreyfus, Tiffany Mathieu, Lionel Tastet, Cedric Renard, Mesut Gun, William Steven Arthur Jenkins, Laurent Macron, Jacob W Sechrist, Joan M Lacomis, Virginia Nguyen, Laura Galian Gay, Hug Cuéllar Calabria, Ioannis Ntalas, Timothy Robert Graham Cartlidge, Bernard Prendergast, Ronak Rajani, Arturo Evangelista, João L Cavalcante, David E Newby, Philippe Pibarot, David Messika Zeitoun, Marc R Dweck
BACKGROUND: Computed tomography aortic valve calcium scoring (CT-AVC) holds promise for the assessment of patients with aortic stenosis (AS). We sought to establish the clinical utility of CT-AVC in an international multicenter cohort of patients. METHODS AND RESULTS: Patients with AS who underwent ECG-gated CT-AVC within 3 months of echocardiography were entered into an international, multicenter, observational registry. Optimal CT-AVC thresholds for diagnosing severe AS were determined in patients with concordant echocardiographic assessments, before being used to arbitrate disease severity in those with discordant measurements...
March 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29553538/following-endocardial-tissue-movements-via-cell-photoconversion-in-the-zebrafish-embryo
#10
Renee Wei-Yan Chow, Paola Lamperti, Emily Steed, Francesco Boselli, Julien Vermot
During embryogenesis, cells undergo dynamic changes in cell behavior, and deciphering the cellular logic behind these changes is a fundamental goal in the field of developmental biology. The discovery and development of photoconvertible proteins have greatly aided our understanding of these dynamic changes by providing a method to optically highlight cells and tissues. However, while photoconversion, time-lapse microscopy, and subsequent image analysis have proven to be very successful in uncovering cellular dynamics in organs such as the brain or the eye, this approach is generally not used in the developing heart due to challenges posed by the rapid movement of the heart during the cardiac cycle...
February 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29549339/the-epicardium-obscures-interpretations-on-endothelial-to-mesenchymal-transition-in-the-mouse-atrioventricular-canal-explant-assay
#11
Nathan Criem, An Zwijsen
Atrioventricular septal defects often result from impaired endocardial cushion development. Endothelial-to-mesenchymal transition (EndoMT) is a critical event in endocardial cushion development that initiates in the atrioventricular canal (AVC). In ex vivo EndoMT studies, mouse AVCs are flat-mounted on a collagen gel. In the explant outgrowths, the ratio of elongated spindle-like mesenchymal cells over cobblestone-shaped cells, generally considered as endothelial cells, reflects EndoMT. Using this method, several key signalling pathways have been attributed important functions during EndoMT...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29524206/clinical-evaluation-of-human-papillomavirus-16-18-oncoprotein-test-for-cervical-cancer-screening-and-hpv-positive-women-triage
#12
Lulu Yu, Mingyue Jiang, Pengpeng Qu, Zeni Wu, Peisong Sun, Mingrong Xi, Yu Qin, Xin Liu, Guangdong Liao, Xiaoqin Lei, Lixin Sun, Yongzhen Zhang, Zhifang Li, Wen Chen, You-Lin Qiao
HPV-16 and -18 account for about 80% of cervical cancers. We evaluated the performance of HPV-16/18 oncoprotein to predict precancer and cancer in corresponding tissue biopsy specimens. 1,008 women attending cervical cancer screening program and 638 women referred to colposcopy with biopsy-confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) from 4 hospitals were recruited (1,646 in total). All women were tested OncoE6 (AVC), Liquid-Based Cytology (Hologic) and cobas HPV test (Roche). Colposcopy was performed on women with any abnormal results...
March 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29486377/questioning-the-automaticity-of-audiovisual-correspondences
#13
Laura M Getz, Michael Kubovy
An audiovisual correspondence (AVC) refers to an observer's seemingly arbitrary yet consistent matching of sensory features across the two modalities; for example, between an auditory pitch and visual size. Research on AVCs has frequently used a speeded classification procedure in which participants are asked to rapidly classify an image when it is either accompanied by a congruent or an incongruent sound (or vice versa). When, as is typically the case, classification is faster in the presence of a congruent stimulus, researchers have inferred that the AVC is automatic and bottom-up...
June 2018: Cognition
https://www.readbyqxmd.com/read/29472027/quantified-degree-of-eccentricity-of-aortic-valve-calcification-predicts-risk-of-paravalvular-regurgitation-and-response-to-balloon-post-dilation-after-self-expandable-transcatheter-aortic-valve-replacement
#14
Jun-Bean Park, In-Chang Hwang, Whal Lee, Jung-Kyu Han, Chi-Hoon Kim, Seung-Pyo Lee, Han-Mo Yang, Eun-Ah Park, Hyung-Kwan Kim, Paul T L Chiam, Yong-Jin Kim, Bon-Kwon Koo, Dae-Won Sohn, Hyuk Ahn, Joon-Won Kang, Seung-Jung Park, Hyo-Soo Kim
BACKGROUND: Limited data exist regarding the impact of aortic valve calcification (AVC) eccentricity on the risk of paravalvular regurgitation (PVR) and response to balloon post-dilation (BPD) after transcatheter aortic valve replacement (TAVR). We investigated the prognostic value of AVC eccentricity in predicting the risk of PVR and response to BPD in patients undergoing TAVR. METHODS: We analyzed 85 patients with severe aortic stenosis who underwent self-expandable TAVR (43 women; 77...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29427025/telemedicine-in-general-neurology-use-of-audiovisual-consultation-for-on-call-back-up-service-in-an-acute-care-hospital
#15
Frank Janssen, Mohammed Awadallah, Awed Alhalabi, Barbara Körber, Reinhard Lang, Mateusz Scibor, René Handschu
OBJECTIVE: While telemedicine is in expanding use in acute stroke care, little is known about its use in general neurology, especially in acute care. We sought to investigate the feasibility and possible effects of a telemedicine device within the neurological back-up service of an acute care hospital. METHODS: In a 450 bed academic teaching hospital an experienced neurologist (EN) is on call to support the junior doctor at the hospital. Support was possible whether by standard telephone advice (TA) or by audiovisual consultations (AVC)...
April 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29384880/risk-factors-for-heart-valve-calcification-in-chronic-kidney-disease
#16
Shu Rong, Xin Qiu, Xiucai Jin, Minghua Shang, Yixin Huang, Zhihuan Tang, Weijie Yuan
Cardiovascular disease (CVD) is a common cause of death in patients with chronic kidney disease (CKD). Aortic and mitral valve calcification (AVC and MVC, respectively) are critical indicators of CVD and all-cause mortality in CKD patients.We conducted a single center retrospective study of Chinese inpatients with CKD to identify risk factors associated with valve calcification (VC).Of 288 enrolled CKD patients, 22.9% had VC, all of which exhibited AVC, while 21.2% exhibited MVC. The VC group were significantly older than the non-VC group (70...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29337121/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2018-update-on-outcomes-and-quality
#17
Jeffrey P Jacobs, John E Mayer, Sara K Pasquali, Kevin D Hill, David M Overman, James D St Louis, S Ram Kumar, Carl L Backer, Charles D Fraser, James S Tweddell, Marshall L Jacobs
The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive registry of clinical outcomes that captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This article summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29321338/improving-access-to-thrombolysis-and-inhospital-management-times-in-ischemic-stroke-a-stepped-wedge-randomized-trial
#18
RANDOMIZED CONTROLLED TRIAL
Julie Haesebaert, Norbert Nighoghossian, Catherine Mercier, Anne Termoz, Sylvie Porthault, Laurent Derex, Pierre-Yves Gueugniaud, Estelle Bravant, Muriel Rabilloud, Anne-Marie Schott
BACKGROUND AND PURPOSE: A suboptimal number of ischemic stroke patients eligible for thrombolysis actually receive it, partly because of extended inhospital delays. We developed a comprehensive program designed for emergency unit staff and evaluated its effectiveness for reducing intrahospital times and improving access to thrombolysis. METHODS: We conducted a randomized stepped-wedge controlled trial in 18 emergency unit. The sequentially implemented training intervention, targeting emergency physicians and nurses, was based on specifically designed videos and interactive simulation workshops on intrahospital management optimization...
February 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29223822/exposure-to-acrylamide-induces-cardiac-developmental-toxicity-in-zebrafish-during-cardiogenesis
#19
Mengmeng Huang, Jingjing Jiao, Jun Wang, Zhidan Xia, Yu Zhang
Acrylamide (AA), an environmental pollutant, has been linked to neurotoxicity, genotoxicity and carcinogenicity. AA is widely used to synthesize polymers for industrial applications, is widely found in Western-style carbohydrate-rich foods and cigarette smoke, and can also be detected in human umbilical cord blood and breast milk. This is the first study that demonstrated the cardiac developmental toxicity of AA in zebrafish embryos. Post-fertilization exposure to AA caused a clearly deficient cardiovascular system with a shrunken heart and abortive morphogenesis and function...
March 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29222044/the-effects-of-assurances-of-voluntary-compliance-on-retail-sales-to-minors-in-the-united-states-2015-2016
#20
Hongying Dai, Delwyn Catley
Multiple state attorneys generals have entered assurances of voluntary compliance (AVCs) with numerous national retail chains as an application of consumer protection laws to help prevent tobacco sales to minors. Little is known about the effectiveness of AVCs in reducing the violations of tobacco retailers for underage sales. We collected inspection data involving minors (n=53,832) on tobacco retailers in 2015 and 2016 from the Food and Drug Administration (FDA) compliance check database. Inspections on 13 national retail chains were classified into four categories: gas stations from oil companies, convenience stores, pharmacy stores, and supermarkets...
December 6, 2017: Preventive Medicine
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