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Autologous chondrocyte implantation

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https://www.readbyqxmd.com/read/28633793/treatment-of-a-focal-articular-cartilage-defect-of-the-talus-with-polymer-based-autologous-chondrocyte-implantation-a-12-year-follow-up-period
#1
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Autologous chondrocyte implantation (ACI) is a first-line treatment option for large articular cartilage defects. Although well-established for cartilage defects in the knee, studies of the long-term outcomes of matrix-assisted ACI to treat cartilage defects in the ankle are rare. In the present report, we describe for the first time the long-term clinical and radiologic results 12 years after polymer-based matrix-assisted ACI treat a full-thickness talar cartilage defect in a 25-year-old male patient. The clinical outcome was assessed using the visual analog scale and Freiburg ankle score, magnetic resonance imaging evaluation using the Henderson-Kreuz scoring system and T2 mapping...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28632455/joint-preservation-techniques-in-orthopaedic-surgery
#2
Philip J York, Frank B Wydra, Matthew E Belton, Armando F Vidal
CONTEXT: With increasing life expectancy, there is growing demand for preservation of native articular cartilage to delay joint arthroplasties, especially in younger, active patients. Damage to the hyaline cartilage of a joint has a limited intrinsic capacity to heal. This can lead to accelerated degeneration of the joint and early-onset osteoarthritis. Treatment in the past was limited, however, and surgical treatment options continue to evolve that may allow restoration of the natural biology of the articular cartilage...
June 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28624853/biophysical-stimulation-improves-clinical-results-of-matrix-assisted-autologous-chondrocyte-implantation-in-the-treatment-of-chondral-lesions-of-the-knee
#3
Marco Collarile, Andrea Sambri, Giada Lullini, Matteo Cadossi, Claudio Zorzi
PURPOSE: The purpose of the present study was to evaluate the effects of pulsed electromagnetic fields (PEMFs) on clinical outcome in patients who underwent arthroscopic matrix-assisted autologous chondrocyte implantation (MACI) for chondral lesions of the knee. METHODS: Thirty patients affected by grade III and IV International Cartilage Repair Society chondral lesions of the knee underwent MACI. After surgery, patients were randomly assigned to either experimental group (PEMFs 4 h per day for 60 days) or control group ...
June 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28597211/characterization-and-use-of-equine-bone-marrow-mesenchymal-stem-cells-in-equine-cartilage-engineering-study-of-their-hyaline-cartilage-forming-potential-when-cultured-under-hypoxia-within-a-biomaterial-in-the-presence-of-bmp-2-and-tgf-%C3%A3-1
#4
Thomas Branly, Lélia Bertoni, Romain Contentin, Rodolphe Rakic, Tangni Gomez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre, Sandrine Jacquet, Fabrice Audigié, Jean-Marie Denoix, Magali Demoor, Philippe Galéra
Articular cartilage presents a poor capacity for self-repair. Its structure-function are frequently disrupted or damaged upon physical trauma or osteoarthritis in humans. Similar musculoskeletal disorders also affect horses and are the leading cause of poor performance or early retirement of sport- and racehorses. To develop a therapeutic solution for horses, we tested the autologous chondrocyte implantation technique developed on human bone marrow (BM) mesenchymal stem cells (MSCs) on horse BM-MSCs. This technique involves BM-MSC chondrogenesis using a combinatory approach based on the association of 3D-culture in collagen sponges, under hypoxia in the presence of chondrogenic factors (BMP-2 + TGF-β1) and siRNA to knockdown collagen I and HtrA1...
June 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28596973/quadriceps-strength-in-patients-with-isolated-cartilage-defects-of-the-knee-results-of-isokinetic-strength-measurements-and-their-correlation-with-clinical-and-functional-results
#5
Anja Hirschmüller, Tasja Andres, Wolfgang Schoch, Heiner Baur, Lukas Konstantinidis, Norbert P Südkamp, Philipp Niemeyer
BACKGROUND: Recent studies have found a significant deficit of maximum quadriceps strength after autologous chondrocyte implantation (ACI) of the knee. However, it is unclear whether muscular strength deficits in patients with cartilage damage exist prior to operative treatment. PURPOSE: To isokinetically test maximum quadriceps muscle strength and quantify the impact of possible strength deficits on functional and clinical test results. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28594507/management-of-osteochondral-lesions-of-the-talus
#6
Michael Isiah Sandlin, Timothy P Charlton, Cyrus E Taghavi, Eric Giza
Management strategies for symptomatic osteochondral lesions of the talus are primarily surgical. Treatment options for symptomatic osteochondral lesions of the talus most commonly include bone marrow stimulation techniques, osteochondral autograft transplantation, osteochondral allograft transplantation, autologous chondrocyte implantation, matrix-induced autologous chondrocyte implantation, and particulated juvenile articular cartilage. The selection of the most appropriate treatment option should be based on the specifics of a talar lesion, in particular, lesion size...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28589877/arthroscopic-treatment-of-chondral-defects-in-the-hip-amic-maci-microfragmented-adipose-tissue-transplantation-matt-and-other-options
#7
Eugenio Jannelli, Andrea Fontana
Chondral lesions are currently considered in the hip as a consequence of trauma, osteonecrosis, dysplasia, labral tears, loose bodies, dislocation, previous slipped capital femoral epiphysis and Femoro-Acetabular-Impingement (FAI). The management of chondral lesions is debated and several techniques are described. The physical examination must be carefully performed, followed by radiographs and magnetic resonance imaging (MRI). Differential diagnosis with other pathologies must be considered. Debridement is indicated in patients younger than 50 years with a chondropathy of 1st or 2nd degree...
2017: SICOT-J
https://www.readbyqxmd.com/read/28589157/return-to-preoperative-function-after-autologous-cartilage-implantation-of-the-knee-in-active-military-servicemembers
#8
Nicholas J Zarkadis, Nicholas A Kusnezov, EStephan J Garcia, Mark P Pallis, Brian R Waterman
BACKGROUND: Autologous chondrocyte implantation (ACI) has been shown to provide adequate durability, pain relief, and improved long-term functional outcomes in the average patient, but proof of its efficacy in individuals with greater than average physical demands is scarce. Further knowledge is required to understand which patients may benefit from ACI and to identify which risk factors are associated with failure to return to the preinjury activity level. PURPOSE: To determine the occupational outcomes, rates of reoperation, and variables predictive of suboptimal outcomes after ACI...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28587484/seven-year-follow-up-of-matrix-induced-autologous-implantation-in-talus-articular-defects
#9
Christopher Kreulen, Eric Giza, Judie Walton, Martin Sullivan
BACKGROUND: Osteochondral lesions of the talus (OLT) are difficult to treat because of the poor intrinsic healing capability of articular cartilage. Matrix-induced autologous chondrocyte implantation (MACI) has been shown to be a reliable method for treating cartilage lesions that fail to respond to traditional microfracture and debridement. The purpose of this study was to assess 7-year clinical follow-up data of this technique and demonstrate midterm success of this implant. METHODS: A prospective investigation of MACI was performed on 10 patients with OLTs who had failed previous arthroscopic treatment...
June 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28583641/osteochondral-lesion-depth-on-mri-can-help-predict-the-need-for-a-sandwich-procedure
#10
R Nizak, J Bekkers, P A de Jong, T Witkamp, T Luijkx, D Saris
PURPOSE: Autologous subchondral bone grafting in combination with autologous chondrocyte implantation (ACI) (sandwich procedure) is a well-accepted procedure for the treatment of osteochondral lesions of the knee. This requires a different surgical technique and preoperative planning compared to ACI alone. In addition, pain from bone marrow donor site locations can be expected and should be part of patient consent and expectations. This study evaluates whether the MRI made as part of the standard preoperative cartilage patient work up has the diagnostic accuracy to predict the need for a sandwich procedure...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28580842/understanding-magnetic-resonance-imaging-of-knee-cartilage-repair-a-focus-on-clinical-relevance
#11
Daichi Hayashi, Xinning Li, Akira M Murakami, Frank W Roemer, Siegfried Trattnig, Ali Guermazi
The aims of this review article are (a) to describe the principles of morphologic and compositional magnetic resonance imaging (MRI) techniques relevant for the imaging of knee cartilage repair surgery and their application to longitudinal studies and (b) to illustrate the clinical relevance of pre- and postsurgical MRI with correlation to intraoperative images. First, MRI sequences that can be applied for imaging of cartilage repair tissue in the knee are described, focusing on comparison of 2D and 3D fast spin echo and gradient recalled echo sequences...
June 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28577711/autologous-chondrocytes-and-next-generation-matrix-based-autologous-chondrocyte-implantation
#12
REVIEW
Betina B Hinckel, Andreas H Gomoll
Focal chondral defects of the knee are common and can significantly impair quality of life. The autologous chondrocyte implantation technique has evolved over the past 20 years; the newest third-generation technique is matrix-induced autologous chondrocyte implantation. Physical examination is important to characterize location and source of pain and identify associated injuries. Imaging studies allow characterization of the lesions, identification of associated lesions, and alignment. Conservative measures should be exhausted before proceeding with surgical treatment...
July 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28577710/allografts-osteochondral-shell-and-paste
#13
REVIEW
Frank B Wydra, Philip J York, Armando F Vidal
There is an increasing need for articular cartilage restoration procedures. Hyaline cartilage lacks intrinsic healing capacity. Persistent osteochondral defects can lead to early and rapid degenerative changes. Microfracture and autologous chondrocyte implantation provide reasonable outcomes for smaller defects without bone loss. However, these techniques have limited effectiveness for lesions greater than 4 cm(2) or with significant bony involvement. Ostochondral allografts provide an option for these lesions...
July 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28574106/biostable-scaffolds-of-polyacrylate-polymers-implanted-in-the-articular-cartilage-induce-hyaline-like-cartilage-regeneration-in-rabbits
#14
María Sancho-Tello, Francisco Forriol, José J Martín de Llano, Carmen Antolinos-Turpin, José A Gómez-Tejedor, José L Gómez Ribelles, Carmen Carda
PURPOSE: To study the influence of scaffold properties on the organization of in vivo cartilage regeneration. Our hypothesis was that stress transmission to the cells seeded inside the pores of the scaffold or surrounding it, which is highly dependent on the scaffold properties, determines the differentiation of both mesenchymal cells and dedifferentiated autologous chondrocytes. METHODS: 4 series of porous scaffolds made of different polyacrylate polymers, previously seeded with cultured rabbit chondrocytes or without cells, were implanted in cartilage defects in rabbits...
May 24, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28542924/effects-of-mechanical-loading-on-human-mesenchymal-stem-cells-for-cartilage-tissue-engineering
#15
REVIEW
Jane Ru Choi, Kar Wey Yong, Jean Yu Choi
Today, articular cartilage damage is a major health problem, affecting people of all ages. The existing conventional articular cartilage repair techniques, such as autologous chondrocyte implantation (ACI), microfracture, and mosaicplasty, have many shortcomings which negatively affect their clinical outcomes. Therefore, it is essential to develop an alternative and efficient articular repair technique that can address those shortcomings. Cartilage tissue engineering, which aims to create a tissue-engineered cartilage derived from human mesenchymal stem cells (MSCs), shows great promise for improving articular cartilage defect therapy...
May 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28518068/3d-magnetic-stem-cell-aggregation-and-bioreactor-maturation-for-cartilage-regeneration
#16
Aurore Van de Walle, Claire Wilhelm, Nathalie Luciani
Cartilage engineering remains a challenge due to the difficulties in creating an in vitro functional implant similar to the native tissue. An approach recently explored for the development of autologous replacements involves the differentiation of stem cells into chondrocytes. To initiate this chondrogenesis, a degree of compaction of the stem cells is required; hence, we demonstrated the feasibility of magnetically condensing cells, both within thick scaffolds and scaffold-free, using miniaturized magnetic field sources as cell attractors...
April 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516106/a-cost-effectiveness-analysis-of-surgical-treatment-modalities-for-chondral-lesions-of-the-knee-microfracture-osteochondral-autograft-transplantation-and-autologous-chondrocyte-implantation
#17
REVIEW
John B Schrock, Matthew J Kraeutler, Darby A Houck, Matthew B McQueen, Eric C McCarty
BACKGROUND: Numerous surgical options exist to treat chondral lesions in the knee, including microfracture (MFx), osteochondral autograft transplantation (OAT), first-generation autologous chondrocyte implantation (ACI-1), and next-generation ACI (ACI-2). PURPOSE: To compare the cost-effectiveness of MFx, OAT, and ACI-1. The secondary purpose of this study was to compare the functional outcomes of MFx, OAT, ACI-1, and ACI-2. STUDY DESIGN: Systematic review; Level of evidence, 2...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28515001/in-vitro-extracellular-matrix-accumulation-of-nasal-and-articular-chondrocytes-for-intervertebral-disc-repair
#18
S Vedicherla, C T Buckley
Chondrocyte based regenerative therapies for intervertebral disc repair such as Autologous Disc Cell Transplantation (ADCT, CODON) and allogeneic juvenile chondrocyte implantation (NuQu(®), ISTO Technologies) have demonstrated good outcomes in clinical trials. However concerns remain with the supply demand reconciliation and issues surrounding immunoreactivity which exist for allogeneic-type technologies. The use of stem cells is challenging due to high growth factor requirements, regulatory barriers and differentiation towards a stable phenotype...
May 8, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28499391/safety-of-three-different-product-doses-in-autologous-chondrocyte-implantation-results-of-a-prospective-randomised-controlled-trial
#19
Christoph Becher, Volker Laute, Stefan Fickert, Wolfgang Zinser, Philipp Niemeyer, Thilo John, Peter Diehl, Thomas Kolombe, Rainer Siebold, Jakob Fay
BACKGROUND: This study was conducted to assess the efficacy and safety of the three dose levels of the three-dimensional autologous chondrocyte implantation product chondrosphere® in the treatment of cartilage defects (4-10 cm(2)) of knee joints. We hereby report the safety results for a 36-month post-treatment observation period. METHODS: This was a prospective phase II trial with a clinical intervention comprising biopsy for culturing spheroids and their subsequent administration (level of evidence: I)...
May 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28425567/chondro-protective-effect-of-ngf-naja-atra-on-chondrocytes-proliferation-and-metabolism-in-vitro
#20
Jiachang Tan, Zhenhui Lu, Zhikang Miao, Danqing Lei, Li Zheng, Jinmin Zhao
Autologous chondrocyte implantation (ACI) is promising strategy for cartilage repair. However, chondrocyte phenotype is easily lost when expanded in vitro which defined as "dedifferentiation." To ensure successful therapy, an effective pro-chondrogenic agent is necessary to overcome the obstacle of limited cell numbers in the restoration process, and dedifferentiation is a prerequisite. In the present study, we investigated the chondro-protective effect of NGF from Chinese cobra venom on human chondrocytes by determination of its specific effect on cell viability, proliferation, morphology, GAG production, and cartilage specific gene expression...
April 20, 2017: Journal of Cellular Biochemistry
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