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Autologous chondrocyte implantation

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https://www.readbyqxmd.com/read/29161138/autologous-matrix-induced-chondrogenesis-a-systematic-review-of-the-clinical-evidence
#1
Liang Gao, Patrick Orth, Magali Cucchiarini, Henning Madry
BACKGROUND: The addition of a type I/III collagen membrane in cartilage defects treated with microfracture has been advocated for cartilage repair, termed "autologous matrix-induced chondrogenesis" (AMIC). PURPOSE: To examine the current clinical evidence regarding AMIC for focal chondral defects. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, ScienceDirect, and Cochrane Library databases...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29160845/vascular-endothelial-growth-factor-sequestration-enhances-in-vivo-cartilage-formation
#2
Carolina M Medeiros Da Cunha, Valeria Perugini, Petra Bernegger, Matteo Centola, Andrea Barbero, Anna L Guildford, Matteo Santin, Andrea Banfi, Ivan Martin, Anna Marsano
Autologous chondrocyte transplantation for cartilage repair still has unsatisfactory clinical outcomes because of inter-donor variability and poor cartilage quality formation. Re-differentiation of monolayer-expanded human chondrocytes is not easy in the absence of potent morphogens. The Vascular Endothelial Growth Factor (VEGF) plays a master role in angiogenesis and in negatively regulating cartilage growth by stimulating vascular invasion and ossification. Therefore, we hypothesized that its sole microenvironmental blockade by either VEGF sequestration by soluble VEGF receptor-2 (Flk-1) or by antiangiogenic hyperbranched peptides could improve chondrogenesis of expanded human nasal chondrocytes (NC) freshly seeded on collagen scaffolds...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156973/cartilage-defect-treatment-using-high-density-autologous-chondrocyte-implantation-two-year-follow-up
#3
Juan Manuel Lopez-Alcorocho, Lucia Aboli, Isabel Guillen-Vicente, Elena Rodriguez-Iñigo, Marta Guillen-Vicente, Tomás F Fernández-Jaén, Santiago Arauz, Steve Abelow, Pedro Guillen-García
OBJECTIVE: The aim of this work was to study the short- and mid-term effectiveness and safety of high-density autologous chondrocyte implantation (HD-ACI) in the first 50 patients with knee cartilage damage treated in our unit. DESIGN: Fifty consecutive patients with cartilage lesions (Outerbridge grade III-IV) in the knee treated with HD-ACI were included in this study. Chondrocytes were isolated from a nonbearing cartilage area biopsy and were cultured until 40 to 50 million cells were obtained...
January 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29146220/autologous-chondrocyte-implantation-for-talar-osteochondral-lesions-comparison-between-5-year-follow-up-magnetic-resonance-imaging-findings-and-7-year-follow-up-clinical-results
#4
Gherardo Pagliazzi, Francesca Vannini, Milva Battaglia, Laura Ramponi, Roberto Buda
Autologous chondrocyte implantation (ACI) is an established surgical procedure that has provided satisfactory results. The aim of the present study was to correlate the clinical outcomes of a series of 20 patients treated by ACI at a 7-year follow-up examination with the magnetic resonance imaging (MRI) T2-mapping 5-year follow-up findings. We evaluated 20 patients using the American Orthopaedic Foot and Ankle Society (AOFAS) score preoperatively and the established follow-up protocol until 87.2 ± 14.5 months...
November 14, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29128878/microfracture-is-more-cost-effective-than-autologous-chondrocyte-implantation-a-review-of-level-1-and-level-2-studies-with-5%C3%A2-year-follow-up
#5
Tommy Frøseth Aae, Per-Henrik Randsborg, Hilde Lurås, Asbjørn Årøen, Øystein Bjerkestrand Lian
PURPOSE: Focal cartilage defects in the knee may have devastating effect on the knee joint, where two of the main surgical treatment options are microfracture and autologous chondrocyte implantation. Comparative studies have failed to establish which method yields the best clinical results. A cost-effectiveness analysis of microfracture and autologous chondrocyte implantation would contribute to the clinical decision process. METHODS: A PubMed search identifying level I and level II studies with 5 year follow-up was performed...
November 11, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#6
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29114638/how-to-manage-a-failed-cartilage-repair-a-systematic-literature-review
#7
REVIEW
Donato Rosa, Sigismondo Luca Di Donato, Giovanni Balato, Alessio D'Addona, Francesco Smeraglia, Gaetano Correra, Gianni Di Vico
Purpose  The aims of this paper are to report the rate and risk factors for the failure of the most common cartilage repair technique, and analyze the most important factors that could influence the choice of a specific surgical treatment to revise a failed cartilage repair. Methods  A review of the literature was performed focusing on failed cartilage repair and related treatments. Two of the authors independently screened articles. Conflicts about the inclusion of a paper was resolved by further evaluation by the senior author...
June 2017: Joints
https://www.readbyqxmd.com/read/29103840/the-influence-of-full-thickness-chondral-defects-on-outcomes-following-meniscal-allograft-transplantation-a-comparative-study
#8
Bryan M Saltzman, Maximilian A Meyer, Timothy S Leroux, Matthew E Gilelis, Margot Debot, Adam B Yanke, Brian J Cole
PURPOSE: To compare a series of patients who underwent meniscus allograft transplantation (MAT) with full-thickness chondral defects (FTD) with those with no chondral defect (ND) with regard to the following: change in patient-reported outcomes (PROs) from baseline to 2-year follow-up and baseline to the final follow-up (including comparisons to minimal clinically important differences), complications and complication rates, reoperations and reoperation rates/timing, and failures and time to failure (revision MAT or conversion to total knee arthroplasty)...
November 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29100004/autologous-chondrocyte-implantation-in-osteoarthritic-surroundings-tnf%C3%AE-and-its-inhibition-by-adalimumab-in-a-knee-specific-bioreactor
#9
Robert Ossendorff, Sibylle Grad, Martin J Stoddart, Mauro Alini, Hagen Schmal, Norbert Südkamp, Gian M Salzmann
BACKGROUND: Autologous chondrocyte implantation (ACI) fails in up to 20% of cases. Advanced intra-articular degeneration paired with an inflammatory environment may be closely related to implantation failure. Certain cytokines have been identified to play a major role during early osteoarthritis. PURPOSE: To investigate the effects of tumor necrosis factor α (TNFα) and its potential inhibition by adalimumab on cartilage regeneration in an in vitro model of ACI...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29083361/chondral-tissue-engineering-of-the-reumatoid-knee-with-collagen-matrix-autologous-chondrocytes-implant
#10
Massimiliano Leigheb, Michela Bosetti, Antonio De Consoli, Alessia Borroni, Mario Cannas, Federico Grassi
Articular cartilage repair is still a challenge. To date evidence is insufficient to support a treatment over the others. Inflammatory conditions in the joint hamper the application of tissue engineering during chronic joint diseases. Most of the Matrix Autologous Chondrocyte Implantation (MACI) cases reported in literature do not deal with rheumatoid knees and do not have a long clinical-histologic follow-up. We report about a 46-year old woman who suffered of a painful focal Outerbridge 4th degree chondral lesion in the medial femoral condyle of her left rheumatoid knee...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29055380/piezoelectric-material-a-promising-approach-for-bone-and-cartilage-regeneration
#11
Namdev More, Govinda Kapusetti
Bone and cartilage are major weight-bearing connective tissues in human and possesses utmost vulnerability for degeneration. The potential causes are mechanical trauma, cancer and disease condition like osteoarthritis and osteoporosis, etc. The regeneration/repair is a challenging, since their complex structures and activities. Current treatment options comprise of auto graft, allograft, artificial bone substituent, autologous chondrocyte implantation, mosaicplasty, marrow stimulation and tissue engineering...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29051878/patellofemoral-articulating-osteochondral-kissing-lesion-treated-with-autologous-chondrocyte-implantation-a-case-report
#12
Taylor J Ridley, Christopher T Rud, Jeffrey A Macalena
INTRODUCTION: Autologous chondrocyte implantation (ACI) is an effective treatment for chondral defects of the knee; however, its use in kissing lesions is less well documented. CASE REPORT: A 23-year-old female with a kissing lesion of the patellofemoral compartment on magnetic resonance imaging underwent two-stage ACI to her medial patella (20 mm × 22 mm) and medial trochlea (27 mm × 18 mm). At 1-year follow-up, the patient had returned to all activities with near-complete resolution of symptoms and substantial improvement in clinical outcome scores...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29037743/the-effect-of-platelet-rich-fibrin-on-autologous-osteochondral-transplantation-an-in-vivo-porcine-model
#13
S Y Sheu, C H Wang, Y H Pao, Y T Fu, C H Liu, C H Yao, T F Kuo
BACKGROUND: This work aimed to evaluate the efficacy of cartilage transplantation to the medial femoral condyle±platelet-rich fibrin (PRF) augmentation in a porcine model. The hypothesis of the study was that PRF may act as a bioactive cell scaffold to fill defects and enhance cartilage regeneration. METHODS: Thirty-two knees of 16 miniature pigs were randomly assigned to four groups. The critical-size osteochondral defects (8x5mm) in femoral condyle of both knees were treated with one of the following: group 1-untreated controls; group 2-cartilage fragments alone; group 3-PRF alone; group 4-PRFT+cartilage fragments...
October 13, 2017: Knee
https://www.readbyqxmd.com/read/29036754/patellofemoral-cartilage-restoration-indications-techniques-and-outcomes-of-autologous-chondrocytes-implantation-matrix-induced-chondrocyte-implantation-and-particulated-juvenile-allograft-cartilage
#14
https://www.readbyqxmd.com/read/28980022/-current-overview-of-cartilage-regeneration-procedures
#15
REVIEW
H Schenker, M Wild, B Rath, M Tingart, A Driessen, V Quack, M Betsch
BACKGROUND: Cartilage is an avascular, alymphatic and non-innervated tissue with limited intrinsic repair potential. The high prevalence of cartilage defects and their tremendous clinical importance are a challenge for all treating physicians. AIM: This article provides the reader with an overview about current cartilage treatment options and their clinical outcome. METHODS: Microfracture is still considered the gold standard in the treatment of small cartilage lesions...
November 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28972948/a-novel-method-to-induce-cartilage-regeneration-with-cubic-microcartilage
#16
Hitoshi Nishiwaki, Mitsugu Fujita, Makoto Yamauchi, Noritaka Isogai, Yasuhiko Tabata, Hirohisa Kusuhara
Cartilage tissue is characterized by its poor regenerative properties, and the clinical performance of cartilage grafts to replace cartilage defects has been unsatisfactory. Recently, cartilage regeneration with mature chondrocytes and stem cells has been developed and applied in clinical settings. However, there are challenges with the use of mature chondrocytes and stem cells for tissue regeneration, including the high costs associated with the standard stem cell isolation methods and the decreased cell viability due to cell manipulation...
October 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28969580/the-potential-for-synovium-derived-stem-cells-in-cartilage-repair
#17
Eva Johanna Kubosch, Gernot Michael Lang, David Fürst, David Christopher Kubosch, Kaywan Izadpanah, Bernd Rolauffs, Norbert P Südkamp, Hagen Schmal
BACKGROUND: Articular cartilage defects often result in pain, loss of function and finally osteoarthritis. Developing cell-based therapies for cartilage repair is a major goal of orthopaedic research. Autologous chondrocyte implantation is currently the gold standard cell-based surgical procedure for the treatment of large, isolated, full thickness cartilage defects. Several disadvantages such as the need for two surgical procedures or hypertrophic regenerative cartilage, underline the need for alternative cell sources...
October 2, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28962209/effects-of-insulin-like-growth-factor-1-and-basic-fibroblast-growth-factor-on-the-morphology-and-proliferation-of-chondrocytes-embedded-in-matrigel-in-a-microfluidic-platform
#18
Yuancheng Li, Qinbo Fan, Yong Jiang, Fuliang Gong, Honggang Xia
An integrated microfluidic device was utilized in the present study to investigate the morphology and proliferation of rabbit articular chondrocytes embedded in Matrigel in the presence of insulin-like growth factor 1 (IGF-1) and/or basic fibroblast growth factor (bFGF). The microfluidic device was composed of two parallel channels and a central perfusion-based three-dimensional cell culture module. The rabbit chondrocytes were cultured for 2 weeks at series of concentration gradients of IGF-1 and/or bFGF, which were generated through a diffusion process...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28951745/in-vivo-articular-cartilage-regeneration-using-human-dental-pulp-stem-cells-cultured-in-an-alginate-scaffold-a-preliminary-study
#19
Manuel Mata, Lara Milian, Maria Oliver, Javier Zurriaga, Maria Sancho-Tello, Jose Javier Martin de Llano, Carmen Carda
Osteoarthritis is an inflammatory disease in which all joint-related elements, articular cartilage in particular, are affected. The poor regeneration capacity of this tissue together with the lack of pharmacological treatment has led to the development of regenerative medicine methodologies including microfracture and autologous chondrocyte implantation (ACI). The effectiveness of ACI has been shown in vitro and in vivo, but the use of other cell types, including bone marrow and adipose-derived mesenchymal stem cells, is necessary because of the poor proliferation rate of isolated articular chondrocytes...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28946629/suitability-of-egcg-as-a-means-of-stabilizing-a-porcine-osteochondral-xenograft
#20
Steven Elder, John Clune, Jaylyn Walker, Paul Gloth
As a non-crosslinked osteochondral xenograft would be mechanically inferior to native cartilage and vulnerable to premature degradation, we seek a safe and effective method of xenograft stabilization. The purpose of this study was to evaluate the capacity for epigallocatechin gallate (EGCG) to stabilize a decellularized porcine osteochondral xenograft through collagen crosslinking. Our objectives were to assess the effects of EGCG on the degree of crosslinking, mechanical properties, collagenase resistance, cytotoxicity, and in vitro biocompatibility...
September 23, 2017: Journal of Functional Biomaterials
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