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Autologous chondrocyte implantation

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https://www.readbyqxmd.com/read/28056183/cell-seeded-autologous-chondrocyte-implantation
#1
Andreas H Gomoll, Amy Phan, Marissa Mastrocola, Luiz Felipe Ambra, Nehal Shah
BACKGROUND: The use of autologous chondrocyte implantation (ACI) remains limited, even though multiple studies have demonstrated success rates exceeding 75%. The procedure is perceived as invasive and technically challenging, presenting barriers to more widespread adoption. Purpose/Hypothesis: The objective of this study was to investigate whether outcomes and the failure rate of a simplified ACI technique (cs-ACI) were comparable with those of the more complicated traditional technique of a chondrocyte suspension injected under a collagen membrane (cACI)...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28045868/failure-of-autologous-chondrocyte-implantation
#2
Luca Andriolo, Giulia Merli, Giuseppe Filardo, Maurilio Marcacci, Elizaveta Kon
: Long-term results of autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation in the knee are satisfying, but not enough attention has been paid to the evaluation of failures. Thus, a systematic review of the literature was performed, underlining a failure rate in the 58 included articles of 14.9% among 4294 patients, most of them occurring in the first 5 years after surgery, and with no difference between autologous chondrocyte implantation and matrix-assisted autologous chondrocyte transplantation...
March 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28012432/promissory-identities-sociotechnical-representations-innovation-in-regenerative-medicine
#3
John Gardner, Ruchi Higham, Alex Faulkner, Andrew Webster
The field of regenerative medicine (RM) is championed as a potential source of curative treatments and economic wealth, and initiatives have been launched in several countries to facilitate innovation within the field. As a way of examining the social dimensions of innovation within regenerative medicine, this paper explores the sociotechnical representations of RM technologies in the UK, and the tensions, affordances and complexities these representations present for actors within the field. Specifically, the paper uses the Science and Technology Studies-inspired notions of 'technology identity' and 'development space' to examine how particular technologies are framed and positioned by actors, and how these positionings subsequently shape innovation pathways...
December 13, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27994720/repair-potential-of-matrix-induced-bone-marrow-aspirate-concentrate-and-matrix-induced-autologous-chondrocyte-implantation-for-talar-osteochondral-repair-patterns-of-some-catabolic-inflammatory-and-pain-mediators
#4
Giovanna Desando, Isabella Bartolotti, Francesca Vannini, Carola Cavallo, Francesco Castagnini, Roberto Buda, Sandro Giannini, Massimiliano Mosca, Erminia Mariani, Brunella Grigolo
OBJECTIVE: The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Aspirate Concentrate (mBMAC) and matrix-induced Autologous Chondrocyte Implantation (mACI) evaluating, on a small number of osteochondral biopsies, the expression of some catabolic, inflammatory, and pain mediators...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994717/evaluation-and-management-of-osteochondral-lesions-of-the-talus
#5
REVIEW
Christopher A Looze, Jason Capo, Michael K Ryan, John P Begly, Cary Chapman, David Swanson, Brian C Singh, Eric J Strauss
Osteochondral lesions of the talus are common injuries that affect a wide variety of active patients. The majority of these lesions are associated with ankle sprains and fractures though several nontraumatic etiologies have also been recognized. Patients normally present with a history of prior ankle injury and/or instability. In addition to standard ankle radiographs, magnetic resonance imaging and computed tomography are used to characterize the extent of the lesion and involvement of the subchondral bone...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27956231/viability-of-cells-from-displaced-fragments-of-the-elbow-osteochondritis-dissecans-alternative-source-of-autologous-chondrocyte-implantation
#6
Yusuke Kameda, Tadanao Funakoshi, Shunsuke Takeuchi, Katsura Sugawara, Norimasa Iwasaki
PURPOSE: To assess the histological properties of cells from displaced fragments obtained from patients with advanced osteochondritis dissecans (OCD) of the elbow and to examine whether these displaced fragments could be used as cell sources for autologous chondrocyte implantation. METHODS: We harvested 6 displaced fragments from 6 patients who underwent osteochondral mosaicplasty for OCD of the elbow. The displaced fragments were examined histologically and digested to obtain chondrocytes...
December 9, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27917821/optimizing-cell-sourcing-for-clinical-translation-of-tissue-engineered-ears
#7
Kerry A Morrison, Benjamin P Cohen, Ope Asanbe, Xue Dong, Alice Harper, Lawrence J Bonassar, Jason A Spector
: Background . Currently, the major impediment to clinical translation of our previously described platform for the fabrication of high fidelity, patient-specific tissue engineered ears is the development of a clinically optimal cell sourcing strategy. A limited autologous auricular chondrocyte (AuC) supply in conjunction with rapid chondrocyte de-differentiation during in vitro expansion currently makes clinical translation more challenging. Mesenchymal stem cells (MSCs) offer significant promise due to their inherent chondrogenic potential, and large availability through minimally invasive procedures...
December 5, 2016: Biofabrication
https://www.readbyqxmd.com/read/27910822/prolonged-in-vitro-precultivation-alleviates-post-implantation-inflammation-and-promotes-stable-subcutaneous-cartilage-formation-in-a-goat-model
#8
Yi Liu, Dan Li, Zongqi Yin, Xusong Luo, Wei Liu, Wenjie Zhang, Zhiyong Zhang, Yilin Cao, Yu Liu, Guangdong Zhou
Synthetic biodegradable scaffolds such as polylactic acid coated polyglycolic acid (PLA-PGA) are especially suitable for engineering shaped cartilage such as auricle, but they induce a serious inflammatory reaction particularly in the immunologically aggressive subcutaneous site, leading to resorption of the engineered autologous cartilage. Our previous study in a rabbit model has demonstrated 2 weeks of in vitro precultivation could significantly alleviate the post-implantation inflammation induced by PLA-PGA engineered cartilaginous grafts, but reproduction of this result failed in a preclinical goat model...
December 2, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27893924/deciding-how-best-to-treat-cartilage-defects
#9
Lucy Oliver-Welsh, Justin W Griffin, Maximilian A Meyer, Matthew E Gitelis, Brian J Cole
The decision-making regarding and treatment of cartilage abnormalities requires a systematic approach. This article reviews the concepts and principles that guide the management of this complex problem. The precise incidence, demographics, and progression of cartilage lesions have not been clearly delineated. Pursuing a patient-centered approach that considers the available nonsurgical and surgical options remains the cornerstone of patient care. The importance of determining concomitant knee pathologies, the proper interpretation and implications of imaging findings, and an accurate determination of the intra-articular and subchondral findings represent the primary elements of the decision analysis...
November 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27882808/no-degeneration-found-in-focal-cartilage-defects-evaluated-with-dgemric-at-12-year-follow-up
#10
Cathrine Nørstad Engen, Sverre Løken, Asbjørn Årøen, Charles Ho, Lars Engebretsen
Background and purpose - The natural history of focal cartilage defects (FCDs) is still unresolved, as is the long-term cartilage quality after cartilage surgery. It has been suggested that delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a biomarker of early OA. We aimed to quantitatively evaluate the articular cartilage in knees with FCDs, 12 years after arthroscopic diagnosis. Patients and methods - We included 21 patients from a cohort of patients with knee pain who underwent arthroscopy in 1999...
November 24, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27881381/two-year-outcomes-of-a-randomized-trial-investigating-a-6-week-return-to-full-weightbearing-after-matrix-induced-autologous-chondrocyte-implantation
#11
Jay R Ebert, Peter K Edwards, Michael Fallon, Timothy R Ackland, Gregory C Janes, David J Wood
BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging outcomes in treating patients with knee cartilage defects. Postoperatively, the time required to attain full weightbearing (WB) remains conservative. HYPOTHESIS: We hypothesized that patients would have no significant clinical or radiological differences or graft complications after an 8-week or 6-week return to full WB after MACI. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
November 23, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27861869/s100b%C3%A2-%C3%A2-a1-celisa-a-novel-potency-assay-and-screening-tool-for-redifferentiation-stimuli-of-human-articular-chondrocytes
#12
Jose Diaz-Romero, Sibylle Kürsener, Sandro Kohl, Dobrila Nesic
During monolayer expansion, a necessary step in autologous chondrocyte implantation, human articular chondrocytes (HAC) dedifferentiate and lose their capacity to produce stable hyaline cartilage. Determining HAC potency and learning how to trigger their redifferentiation would improve cell-based cartilage regeneration therapies. We previously identified S100B and S100A1 proteins as markers of HAC redifferentiation potential. Here, we aimed to: (i) demonstrate a correlation between S100B + A1-positive HAC in monolayer culture and their neochondrogenesis capacity in pellet culture; (ii) develop an S100B + A1 cell-based ELISA, and (iii) prove that S100B + A1 induction in HAC increases their chondrogenic capacity...
November 11, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27846904/an-ex-vivo-human-cartilage-repair-model-to-evaluate-the-potency-of-a-cartilage-cell-transplant
#13
Christoph Bartz, Miriam Meixner, Petra Giesemann, Giulietta Roël, Grit-Carsta Bulwin, Jeske J Smink
BACKGROUND: Cell-based therapies such as autologous chondrocyte implantation are promising therapeutic approaches to treat cartilage defects to prevent further cartilage degeneration. To assure consistent quality of cell-based therapeutics, it is important to be able to predict the biological activity of such products. This requires the development of a potency assay, which assesses a characteristic of the cell transplant before implantation that can predict its cartilage regeneration capacity after implantation...
November 15, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27835044/patient-experiences-of-recovery-after-autologous-chondrocyte-implantation-a-qualitative-study
#14
Jenny L Toonstra, Dana Howell, Robert A English, Christian Lattermann, Carl G Mattacola
CONTEXT:  The recovery process after autologous chondrocyte implantation (ACI) can be challenging for patients and clinicians alike due to significant functional limitations and a lengthy healing time. Understanding patients' experiences during the recovery process may assist clinicians in providing more individualized care. OBJECTIVE:  To explore and describe patients' experiences during the recovery process after ACI. DESIGN:  Qualitative study...
November 1, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27826762/matrix-based-autologous-chondrocyte-implantation-in-children-and-adolescents-a-match-paired-analysis-in-a-follow-up-over-three-years-post-operation
#15
Thomas Richard Niethammer, Martin Holzgruber, Mehmet Fatih Gülecyüz, Patrick Weber, Matthias Frank Pietschmann, Peter Ernst Müller
PURPOSE: The aim of this study is the investigation of the clinical results after third generation autologous chondrocyte implantation in the knee in a follow-up over three years post-operation. Our primary focus is on the effects of this procedure on children and adolescent patients as there is a lack of knowledge regarding the clinical outcomes in children/adolescents in particular when compared with adults. METHODS: A total of 40 patients (43 defects) <20 years with cartilage defects of the knee were treated with third generation ACI (Novocart® 3D)...
November 8, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27822208/human-articular-chondrocytes-regulate-immune-response-by-affecting-directly-t-cell-proliferation-and-indirectly-inhibiting-monocyte-differentiation-to-professional-antigen-presenting-cells
#16
Rui C Pereira, Daniela Martinelli, Ranieri Cancedda, Chiara Gentili, Alessandro Poggi
Autologous chondrocyte implantation is the current gold standard cell therapy for cartilage lesions. However, in some instances, the heavily compromised health of the patient can either impair or limit the recovery of the autologous chondrocytes and a satisfactory outcome of the implant. Allogeneic human articular chondrocytes (hAC) could be a good alternative, but the possible immunological incompatibility between recipient and hAC donor should be considered. Herein, we report that allogeneic hAC inhibited T lymphocyte response to antigen-dependent and -independent proliferative stimuli...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27803938/biological-knee-reconstruction-with-concomitant-autologous-chondrocyte-implantation-and-meniscal-allograft-transplantation-mid-to-long-term-outcomes
#17
Takahiro Ogura, Tim Bryant, Tom Minas
BACKGROUND: Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation (ACI) and meniscal allograft transplantation (MAT), longer follow-up is needed. PURPOSE: To evaluate mid- to long-term outcomes after combined ACI with MAT. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We performed a retrospective review of prospectively gathered data from patients who had undergone ACI with MAT between 1999 and 2013...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27789021/nasal-chondrocyte-based-engineered-autologous-cartilage-tissue-for-repair-of-articular-cartilage-defects-an-observational-first-in-human-trial
#18
Marcus Mumme, Andrea Barbero, Sylvie Miot, Anke Wixmerten, Sandra Feliciano, Francine Wolf, Adelaide M Asnaghi, Daniel Baumhoer, Oliver Bieri, Martin Kretzschmar, Geert Pagenstert, Martin Haug, Dirk J Schaefer, Ivan Martin, Marcel Jakob
BACKGROUND: Articular cartilage injuries have poor repair capacity, leading to progressive joint damage, and cannot be restored predictably by either conventional treatments or advanced therapies based on implantation of articular chondrocytes. Compared with articular chondrocytes, chondrocytes derived from the nasal septum have superior and more reproducible capacity to generate hyaline-like cartilage tissues, with the plasticity to adapt to a joint environment. We aimed to assess whether engineered autologous nasal chondrocyte-based cartilage grafts allow safe and functional restoration of knee cartilage defects...
October 22, 2016: Lancet
https://www.readbyqxmd.com/read/27781068/chondrogenic-potency-analyses-of-donor-matched-chondrocytes-and-mesenchymal-stem-cells-derived-from-bone-marrow-infrapatellar-fat-pad-and-subcutaneous-fat
#19
John Garcia, Claire Mennan, Helen S McCarthy, Sally Roberts, James B Richardson, Karina T Wright
Autologous chondrocyte implantation (ACI) is a cell-based therapy that has been used clinically for over 20 years to treat cartilage injuries more efficiently in order to negate or delay the need for joint replacement surgery. In this time, very little has changed in the ACI procedure, but now many centres are considering or using alternative cell sources for cartilage repair, in particular mesenchymal stem cells (MSCs). In this study, we have tested the chondrogenic potential of donor-matched MSCs derived from bone marrow (BM), infrapatellar fat pad (FP), and subcutaneous fat (SCF), compared to chondrocytes...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27773574/a-case-study-glycosaminoglycan-profiles-of-autologous-chondrocyte-implantation-aci-tissue-improve-as-the-tissue-matures
#20
Aarti Sharma, Dai Rees, Sally Roberts, Nicola J Kuiper
BACKGROUND: Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects in thousands of patients worldwide with good clinical effectiveness 10-20years after implantation. Information concerning the quality of the repair cartilage is still limited because biopsies are small and rare. Glycosaminoglycan structure influences physiological function and is likely to be important in the long term stability of the repair tissue. The aim of this study was to assess glycosaminoglycans in ACI tissue over a two year period...
October 20, 2016: Knee
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