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https://www.readbyqxmd.com/read/27776949/beh%C3%A3-et-s-disease%C3%A2-and-fmf-two-sides-of-the-same-coin-or-just-an-association-a-cross-sectional-study%C3%A2
#1
Abdulla Watad, Shmuel Tiosano, Dana Yahav, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Howard Amital
BACKGROUND: Familial Mediterranean fever (FMF) is a genetic disease, characterized by attacks of fever, arthritis, serositis and pain. Behçet's disease (BD) is an inflammatory disorder with a genetic basis, characterized by oral and genital ulcers, uveitis, pustular erythematous cutaneous lesions, arthritis, central nervous system involvement and possible vascular manifestations such as venous thrombosis, arteritis and aneurysms. OBJECTIVES: To investigate the association and actual differentiation between these two entities in a large-scale population-based study...
October 21, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27687821/systematic-review-of-the-performance-of-noninvasive-tests-in-diagnosing-bladder-outlet-obstruction-in-men-with-lower-urinary-tract-symptoms
#2
Sachin Malde, Arjun K Nambiar, Roland Umbach, Thomas B Lam, Thorsten Bach, Alexander Bachmann, Marcus J Drake, Mauro Gacci, Christian Gratzke, Stephan Madersbacher, Charalampos Mamoulakis, Kari A O Tikkinen, Stavros Gravas
CONTEXT: Several noninvasive tests have been developed for diagnosing bladder outlet obstruction (BOO) in men to avoid the burden and morbidity associated with invasive urodynamics. The diagnostic accuracy of these tests, however, remains uncertain. OBJECTIVE: To systematically review available evidence regarding the diagnostic accuracy of noninvasive tests in diagnosing BOO in men with lower urinary tract symptoms (LUTS) using a pressure-flow study as the reference standard...
September 26, 2016: European Urology
https://www.readbyqxmd.com/read/27508598/-op-lb03-09-the-acute-effect-of-the-specific-creatine-kinase-inhibitor-beta-gpa-in-healthy-man-abc-trial-a-randomized-placebo-and-active-controlled-first-in-human-trial
#3
F A Karamat, D Horjus, Y Haan, L Van Der Woude, M Schaap, I Oudman, G Van Montfrans, R Nieuwland, J Clark, A Sturk, L Brewster
OBJECTIVE: There is increasing evidence that the ATP generating enzyme creatine kinase (CK) is involved in hypertension. The enzyme is central to the regeneration of ATP by using creatine phosphate and ADP, thereby forming creatine and ATP. We recently showed that beta-guanidinopropionic acid (GPA), a creatine analogue and competitive CK inhibitor, effectively and safely reduced blood pressure in the spontaneously hypertensive rat. This renders GPA to be potentially beneficial for blood pressure lowering...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27149859/assessing-an-effective-feeding-strategy-to-optimize-crude-glycerol-utilization-as-sustainable-carbon-source-for-lipid-accumulation-in-oleaginous-yeasts
#4
Lorenzo Signori, Diletta Ami, Riccardo Posteri, Andrea Giuzzi, Paolo Mereghetti, Danilo Porro, Paola Branduardi
BACKGROUND: Microbial lipids can represent a valuable alternative feedstock for biodiesel production in the context of a viable bio-based economy. This production can be driven by cultivating some oleaginous microorganisms on crude-glycerol, a 10% (w/w) by-product produced during the transesterification process from oils into biodiesel. Despite attractive, the perspective is still economically unsustainable, mainly because impurities in crude glycerol can negatively affect microbial performances...
2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/26332293/treatment-failure-with-rhythm-and-rate-control-strategies-in-patients-with-atrial-fibrillation-and-congestive-heart-failure-an-af-chf-substudy
#5
MULTICENTER STUDY
Katia Dyrda, Denis Roy, Hugues Leduc, Mario Talajic, Lynne Warner Stevenson, Peter G Guerra, Jason Andrade, Marc Dubuc, Laurent Macle, Bernard Thibault, Lena Rivard, Paul Khairy
INTRODUCTION: Rate and rhythm control strategies for atrial fibrillation (AF) are not always effective or well tolerated in patients with congestive heart failure (CHF). We assessed reasons for treatment failure, associated characteristics, and effects on survival. METHODS AND RESULTS: A total of 1,376 patients enrolled in the AF-CHF trial were followed for 37  ±  19 months, 206 (15.0%) of whom failed initial therapy leading to crossover. Rhythm control was abandoned more frequently than rate control (21...
December 2015: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/26138654/altered-bile-acid-metabolome-in-patients-with-nonalcoholic-steatohepatitis
#6
COMPARATIVE STUDY
Brian C Ferslew, Guoxiang Xie, Curtis K Johnston, Mingming Su, Paul W Stewart, Wei Jia, Kim L R Brouwer, A Sidney Barritt
BACKGROUND AND AIMS: The prevalence of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the development and progression of NAFLD to NASH and cirrhosis is poorly understood. This study aimed to quantify the bile acid metabolome in healthy subjects and patients with non-cirrhotic NASH under fasting conditions and after a standardized meal. METHODS: Liquid chromatography tandem mass spectroscopy was used to quantify 30 serum and 16 urinary bile acids from 15 healthy volunteers and 7 patients with biopsy-confirmed NASH...
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26030301/implementation-research-to-inform-the-use-of-xpert-mtb-rif-in-primary-health-care-facilities-in-high-tb-and-hiv-settings-in-resource-constrained-settings
#7
Monde Muyoyeta, Maureen Moyo, Nkatya Kasese, Mapopa Ndhlovu, Deborah Milimo, Winfridah Mwanza, Nathan Kapata, Albertus Schaap, Peter Godfrey Faussett, Helen Ayles
BACKGROUND: The current cost of Xpert MTB RIF (Xpert) consumables is such that algorithms are needed to select which patients to prioritise for testing with Xpert. OBJECTIVE: To evaluate two algorithms for prioritisation of Xpert in primary health care settings in a high TB and HIV burden setting. METHOD: Consecutive, presumptive TB patients with a cough of any duration were offered either Xpert or Fluorescence microscopy (FM) test depending on their CXR score or HIV status...
2015: PloS One
https://www.readbyqxmd.com/read/25948378/a-patient-with-polymerase-e1-deficiency-pole1-clinical-features-and-overlap-with-dna-breakage-instability-syndromes
#8
Isabelle Thiffault, Carol Saunders, Janda Jenkins, Nikita Raje, Kristi Canty, Mukta Sharma, Lauren Grote, Holly I Welsh, Emily Farrow, Greyson Twist, Neil Miller, David Zwick, Lee Zellmer, Stephen F Kingsmore, Nicole P Safina
BACKGROUND: Chromosome instability syndromes are a group of inherited conditions associated with chromosomal instability and breakage, often leading to immunodeficiency, growth retardation and increased risk of malignancy. CASE PRESENTATION: We performed exome sequencing on a girl with a suspected chromosome instability syndrome that manifested as growth retardation, microcephaly, developmental delay, dysmorphic features, poikiloderma, immune deficiency with pancytopenia, and myelodysplasia...
2015: BMC Medical Genetics
https://www.readbyqxmd.com/read/25888414/the-acute-effect-of-beta-guanidinopropionic-acid-versus-creatine-or-placebo-in-healthy-men-abc-trial-study-protocol-for-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Fares A Karamat, Deborah L Horjus, Yentl C Haan, Lisa van der Woude, Inge Oudman, Gert A van Montfrans, Joseph F Clark, Lizzy M Brewster
BACKGROUND: Despite adequate treatment, up to 30% of treated antihypertensive patients with primary, uncomplicated hypertension remain uncontrolled. We proposed that high intracellular activity of the ATP regenerating enzyme creatine kinase (CK) increases pressor responses and hypertension risk. In line with this, we found that plasma CK activity after rest, a surrogate measure of tissue activity, is the main predictor of blood pressure levels and failure of antihypertensive therapy in the general population...
February 22, 2015: Trials
https://www.readbyqxmd.com/read/25778581/the-acute-effect-of-beta-guanidinopropionic-acid-versus-creatine-or-placebo-in-healthy-men-abc-trial-study-protocol-for-a-randomized-controlled-trial
#10
Fares A Karamat, Deborah L Horjus, Yentl C Haan, Lisa van der Woude, Inge Oudman, Gert A van Montfrans, Joseph F Clark, Lizzy M Brewster
BACKGROUND: Despite adequate treatment, up to 30% of treated antihypertensive patients with primary, uncomplicated hypertension remain uncontrolled. We proposed that high intracellular activity of the ATP regenerating enzyme creatine kinase (CK) increases pressor responses and hypertension risk. In line with this, we found that plasma CK activity after rest, a surrogate measure of tissue activity, is the main predictor of blood pressure levels and failure of antihypertensive therapy in the general population...
December 2015: Trials
https://www.readbyqxmd.com/read/25653700/impact-of-smoking-on-clinical-outcomes-in-female-patients-with-acute-myocardial-infarction
#11
Yun Ah Jeong, Myung Ho Jeong, Hae Chang Jeong, Youngkeun Ahn, Young Jo Kim, Chong Jin Kim, Myeong Chan Cho
BACKGROUND AND OBJECTIVES: Cigarette smoking has been recognized as a prominent threat to women's health. We investigated the impact of smoking on clinical outcomes in Korean female patients after acute myocardial infarction (AMI). SUBJECTS AND METHODS: Out of the AMI patients who enrolled in the Korea AMI Registry, 4444 female patients were included in this study. Patients were divided into two groups-non-smoker and smoker-according to their current smoking status...
January 2015: Korean Circulation Journal
https://www.readbyqxmd.com/read/25607136/in-fiber-torsion-sensor-based-on-dual-polarized-mach-zehnder-interference
#12
Lei Chen, Wei-Gang Zhang, Li Wang, Hao Zhang, Jonathan Sieg, Quan Zhou, Li-Yu Zhang, Biao Wang, Tie-Yi Yan
This paper presents a novel optical fiber torsion sensor based on dual polarized Mach-Zehnder interference (DPMZI). Unlike the conventional fiber sensor, the proposed sensor is composed of a sensor part and a demodulator. The demodulator is made by a bared single mode fiber (SMF) loop, and the sensor part is a segment of a coated SMF placed before the loop. A mathematical model is proposed based on DPMZI mechanism and from the model when the sensor part is twisted, the E-field rotational angle will bring a quasi-linear impact on the resonance dip wavelength in their matched detecting range...
December 29, 2014: Optics Express
https://www.readbyqxmd.com/read/25595919/technical-factors-associated-with-anastomotic-leak-after-roux-en-y-gastric-bypass
#13
MULTICENTER STUDY
Mark D Smith, Abidemi Adeniji, Abdus S Wahed, Emma Patterson, William Chapman, Anita P Courcoulas, Gregory Dakin, David Flum, Carol McCloskey, James E Mitchell, Alfons Pomp, Myrlene Staten, Bruce Wolfe
BACKGROUND: Anastomotic leak is one of the most serious complications after Roux-en-Y gastric bypass (RYGB). Our objective was to examine the relationship between technical factors and incidence of clinically relevant anastomotic leak after RYGB in longitudinal assessment of bariatric surgery (LABS). The setting of the study was 11 bariatric centers in the United States, university, and private practice. METHODS: Patient characteristics, technical factors of surgery, and postoperative outcomes were assessed by trained researchers using standardized protocols...
March 2015: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/25516675/costs-of-laparoscopic-and-open-liver-and-pancreatic-resection-a-systematic-review
#14
REVIEW
Paolo Limongelli, Chiara Vitiello, Andrea Belli, Madhava Pai, Salvatore Tolone, Gianmattia Del Genio, Luigi Brusciano, Giovanni Docimo, Nagy Habib, Giulio Belli, Long Richard Jiao, Ludovico Docimo
AIM: To study costs of laparoscopic and open liver and pancreatic resections, all the compiled data from available observational studies were systematically reviewed. METHODS: A systematic review of the literature was performed using the Medline, Embase, PubMed, and Cochrane databases to identify all studies published up to 2013 that compared laparoscopic and open liver [laparoscopic hepatic resection (LLR) vs open liver resection (OLR)] and pancreatic [laparoscopic pancreatic resection (LPR) vs open pancreatic resection] resection...
December 14, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25413420/efficiency-gains-for-spinal-radiosurgery-using-multicriteria-optimization-intensity-modulated-radiation-therapy-guided-volumetric-modulated-arc-therapy-planning
#15
Huixiao Chen, Brian A Winey, Juliane Daartz, Kevin S Oh, John H Shin, David P Gierga
PURPOSE: To evaluate plan quality and delivery efficiency gains of volumetric modulated arc therapy (VMAT) versus a multicriteria optimization-based intensity modulated radiation therapy (MCO-IMRT) for stereotactic radiosurgery of spinal metastases. METHODS AND MATERIALS: MCO-IMRT plans (RayStation V2.5; RaySearch Laboratories, Stockholm, Sweden) of 10 spinal radiosurgery cases using 7-9 beams were developed for clinical delivery, and patients were replanned using VMAT with partial arcs...
January 2015: Practical Radiation Oncology
https://www.readbyqxmd.com/read/25383344/effect-of-ultrasonic-tip-designs-on-intraradicular-post-removal
#16
Anny Carine Barros Aguiar, Daniely Amorim de Meireles, André Augusto Franco Marques, Emílio Carlos Sponchiado Júnior, Angela Delfina Bitencourt Garrido, Lucas da Fonseca Roberti Garcia
OBJECTIVES: To evaluate the effect of different ultrasonic tip designs on intraradicular post removal. MATERIALS AND METHODS: The crowns of forty human canine teeth were removed, and after biomechanical preparation and filling, the roots were embedded in acrylic resin blocks. The post spaces were made, and root canal molding was performed with self-cured acrylic resin. After casting (Cu-Al), the posts were cemented with zinc phosphate cement. The specimens were randomly separated into 4 groups (n = 10), as follows: G1 - no ultrasonic vibration (control); G2 - ultrasonic vibration using an elongated cylindrical-shaped and active rounded tip; G3 - ultrasonic vibration with a flattened convex and linear active tip; G4 - ultrasonic vibration with active semicircular tapered tip...
November 2014: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/25119113/identification-and-association-of-the-single-nucleotide-polymorphisms-c-509t-c-466t-and-t-869c-of-the-tgf-%C3%AE-1-gene-in-patients-with-asthma-and-their-influence-on-the-mrna-expression-level-of-tgf-%C3%AE-1
#17
Michał Panek, Tadeusz Pietras, Artur Fabijan, Jan Zioło, Lukasz Wieteska, Beata Małachowska, Wojciech Fendler, Janusz Szemraj, Piotr Kuna
Transforming growth factor-β1 (TGF-β1) is an important fibrogenic and immunomodulatory cytokine participating in the pathogenesis of a number of illnesses related to the growth, differentiation and migration of cells. It also plays a key role in inflammation, atherosclerosis, vascular inflammation and asthma. The aim of the present study was to evaluate the association between the expression of the TGF-β1 gene and its genetic polymorphisms, and the disease phenotype. The study comprised 173 patients with asthma, as well as 163 healthy volunteers as a control group...
October 2014: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/25021535/pwe-053%C3%A2-variation-in-adenoma-detection-rate-in-bowelscope-screening
#18
R Bevan, C Nickerson, R Blanks, J Patnick, R Loke, B Saunders, J Stebbing, R Tighe, A Veitch, J Painter, Cj Rees
INTRODUCTION: The English Bowel Cancer Screening Programme has been expanded to include a one-off flexible sigmoidoscopy offered to all 55 year olds, called BowelScope Screening. Screening commenced in May 2013, with 6 pilots sites performing flexible sigmoidoscopies in the first 8 months of screening. METHODS: The NHS Bowel Cancer Screening System database was interrogated and ADRs reviewed for each screening centre and screening endoscopist. A funnel plot was constructed using the log odds method...
June 2014: Gut
https://www.readbyqxmd.com/read/24686161/not-just-a-rural-occurrence-differences-in-agricultural-equipment-crash-characteristics-by-rural-urban-crash-site-and-proximity-to-town
#19
Karisa K Harland, Mitchell Greenan, Marizen Ramirez
PURPOSE: Although approximately one-third of agricultural equipment-related crashes occur near town, these crashes are thought to be a rural problem. This analysis examines differences between agricultural equipment-related crashes by their urban-rural distribution and distance from a town. METHODS: Agricultural equipment crashes were collected from nine Midwest Departments of Transportation (2005-2008). Crash zip code was assigned as urban or rural (large, small and isolated) using Rural-Urban Commuting Areas...
September 2014: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/24108572/depth-dependent-refractive-index-of-normal-and-early-degenerated-articular-cartilage
#20
Kuyu Wang, Jianping Wu, Thomas Brett Kirk
The depth distributions of refractive index (RI) in normal and early degenerated articular cartilage (AC) were measured and correlated to the pathological statuses. Utilizing a confocal microscope, the depth distribution of RI was determined with an interval of 50 μm from the articular surface and approximated as a smooth curve. The fluctuation of RI was quantified with a specially defined coefficient and the proteoglycan (PG) loss was quantified with histological images. The overall RI of the AC collected from the femoral condyles of mature sheep was 1...
October 2013: Journal of Biomedical Optics
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