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https://www.readbyqxmd.com/read/28705656/impact-of-enteroviral-polymerase-chain-reaction-testing-on-length-of-stay-for-infants-60-days-old-or-younger
#1
Paul L Aronson, Todd W Lyons, Andrea T Cruz, Stephen B Freedman, Pamela J Okada, Alesia H Fleming, Joseph L Arms, Amy D Thompson, Suzanne M Schmidt, Jeffrey Louie, Michael J Alfonzo, Michael C Monuteaux, Lise E Nigrovic
OBJECTIVE: To determine the impact of a cerebrospinal fluid enterovirus polymerase chain reaction (PCR) test performance on hospital length of stay (LOS) in a large multicenter cohort of infants undergoing evaluation for central nervous system infection. STUDY DESIGN: We performed a planned secondary analysis of a retrospective cohort of hospitalized infants ≤60 days of age who had a cerebrospinal fluid culture obtained at 1 of 18 participating centers (2005-2013)...
July 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28545076/temporal-trends-in-stroke-incidence-in-south-asian-chinese-and-white-patients-a-population-based-analysis
#2
Nadia A Khan, Finlay A McAlister, Louise Pilote, Anita Palepu, Hude Quan, Michael D Hill, Jiming Fang, Moira K Kapral
BACKGROUND: Little is known about potential ethnic differences in stroke incidence. We compared incidence and time trends of ischemic stroke and primary intracerebral hemorrhage in South Asian, Chinese and white persons in a population-based study. METHODS: Population based census and administrative data analysis in the provinces of Ontario and British Columbia, Canada using validated ICD 9/ICD 10 coding for acute ischemic and hemorrhagic stroke (1997-2010). RESULTS: There were 3290 South Asians, 4444 Chinese and 160944 white patients with acute ischemic stroke and 535 South Asian, 1376 Chinese and 21842 white patients with intracerebral hemorrhage...
2017: PloS One
https://www.readbyqxmd.com/read/28527973/molecular-analysis-of-group-a-rotaviruses-detected-in-hospitalized-children-from-rawalpindi-pakistan-during-2014
#3
Massab Umair, Bilal Haider Abbasi, Nadia Nisar, Muhammad Masroor Alam, Salmaan Sharif, Shahzad Shaukat, Muhammad Suleman Rana, Adnan Khurshid, Ghulam Mujtaba, Uzma Bashir Aamir, Syed Sohail Zahoor Zaidi
As a part of strategy to control diarrheal diseases, World Health Organization (WHO) recommends to include rotavirus vaccines in national immunization programs. Sentinel surveillance networks have been established to monitor rotavirus disease burden and genotype distribution in both pre and post vaccine era in many countries. Unfortunately, due to lack of proper surveillance programs, data on rotavirus disease burden and genotype distribution from Pakistan is scarce. We investigated 502 stool samples from children (<5years) hospitalized due to gastroenteritis in Rawalpindi, Pakistan during 2014 for the presence of group A rotavirus (RVA) and its genotypic diversity...
May 17, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28435323/ambulatory-thyroidectomy-an-anesthesiologist-s-perspective
#4
REVIEW
Benjamin Murray, Sankalap Tandon, Ged Dempsey
Thyroidectomy has been performed on an inpatient basis because of concerns regarding postoperative complications. These include cervical hematoma, bilateral recurrent laryngeal nerve injury and symptomatic hypocalcemia. We have reviewed the current available evidence and aimed to collate published data to generate incidence of the important complications. We performed a literature search of Medline, EMBASE and the Cochrane database of randomized trials. One hundred sixty papers were included. Twenty-one papers fulfilled inclusion criteria...
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/28199991/left-ventricular-longitudinal-strain-in-soccer-referees
#5
Luigi Gianturco, Bruno Bodini, Vincenzo Gianturco, Giuseppina Lippo, Agnese Solbiati, Maurizio Turiel
Along the years, the analysis of soccer referees perfomance has interested the experts and we can find several types of studies in literature using in particular cardiac imaging. The aim of this retrospective study was to observe relationship between VO2max uptake and some conventional and not-conventional echocardiographic parameters. In order to perform this evaluation, we have enrolled 20 referees, belonging to Italian Soccer Referees' Association and we have investigated cardiovascular profile of them. We found a strong direct relationship between VO2max and global longitudinal strain of left ventricle assessed by means of speckle tracking echocardiographic analysis (R2=0...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28114552/association-between-diabetes-and-cause-specific-mortality-in-rural-and-urban-areas-of-china
#6
Fiona Bragg, Michael V Holmes, Andri Iona, Yu Guo, Huaidong Du, Yiping Chen, Zheng Bian, Ling Yang, William Herrington, Derrick Bennett, Iain Turnbull, Yongmei Liu, Shixian Feng, Junshi Chen, Robert Clarke, Rory Collins, Richard Peto, Liming Li, Zhengming Chen
Importance: In China, diabetes prevalence has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently associated with diabetes. Objectives: To assess the proportional excess mortality associated with diabetes and estimate the diabetes-related absolute excess mortality in rural and urban areas of China. Design, Setting, and Participants: A 7-year nationwide prospective study of 512 869 adults aged 30 to 79 years from 10 (5 rural and 5 urban) regions in China, who were recruited between June 2004 and July 2008 and were followed up until January 2014...
January 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28038878/long-term-exposure-to-ambient-air-pollution-and-mortality-in-a-chinese-tuberculosis-cohort
#7
Zhuoxin Peng, Cong Liu, Biao Xu, Haidong Kan, Weibing Wang
BACKGROUND: Evidence for the relationship between exposure to ambient air pollution and the mortality of tuberculosis (TB) patients is limited. METHODS: We analyzed the association between long-term exposure to particulate matter <2.5μm in diameter (PM2.5) and cause-specific mortality in a Chinese TB patients cohort from 2003 to 2013. Data from the Global Burden of Disease 2013 estimate were used to assess yearly average concentrations of PM2.5 and ozone at the household addresses of participants...
February 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27776949/beh%C3%A3-et-s-disease%C3%A2-and-fmf-two-sides-of-the-same-coin-or-just-an-association-a-cross-sectional-study%C3%A2
#8
Abdulla Watad, Shmuel Tiosano, Dana Yahav, Doron Comaneshter, Yehuda Shoenfeld, Arnon D Cohen, Howard Amital
BACKGROUND: Familial Mediterranean fever (FMF) is a genetic disease, characterized by attacks of fever, arthritis, serositis and pain. Behçet's disease (BD) is an inflammatory disorder with a genetic basis, characterized by oral and genital ulcers, uveitis, pustular erythematous cutaneous lesions, arthritis, central nervous system involvement and possible vascular manifestations such as venous thrombosis, arteritis and aneurysms. OBJECTIVES: To investigate the association and actual differentiation between these two entities in a large-scale population-based study...
October 21, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27687821/systematic-review-of-the-performance-of-noninvasive-tests-in-diagnosing-bladder-outlet-obstruction-in-men-with-lower-urinary-tract-symptoms
#9
REVIEW
Sachin Malde, Arjun K Nambiar, Roland Umbach, Thomas B Lam, Thorsten Bach, Alexander Bachmann, Marcus J Drake, Mauro Gacci, Christian Gratzke, Stephan Madersbacher, Charalampos Mamoulakis, Kari A O Tikkinen, Stavros Gravas
CONTEXT: Several noninvasive tests have been developed for diagnosing bladder outlet obstruction (BOO) in men to avoid the burden and morbidity associated with invasive urodynamics. The diagnostic accuracy of these tests, however, remains uncertain. OBJECTIVE: To systematically review available evidence regarding the diagnostic accuracy of noninvasive tests in diagnosing BOO in men with lower urinary tract symptoms (LUTS) using a pressure-flow study as the reference standard...
March 2017: European Urology
https://www.readbyqxmd.com/read/27508598/-op-lb03-09-the-acute-effect-of-the-specific-creatine-kinase-inhibitor-beta-gpa-in-healthy-man-abc-trial-a-randomized-placebo-and-active-controlled-first-in-human-trial
#10
F A Karamat, D Horjus, Y Haan, L Van Der Woude, M Schaap, I Oudman, G Van Montfrans, R Nieuwland, J Clark, A Sturk, L Brewster
OBJECTIVE: There is increasing evidence that the ATP generating enzyme creatine kinase (CK) is involved in hypertension. The enzyme is central to the regeneration of ATP by using creatine phosphate and ADP, thereby forming creatine and ATP. We recently showed that beta-guanidinopropionic acid (GPA), a creatine analogue and competitive CK inhibitor, effectively and safely reduced blood pressure in the spontaneously hypertensive rat. This renders GPA to be potentially beneficial for blood pressure lowering...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27149859/assessing-an-effective-feeding-strategy-to-optimize-crude-glycerol-utilization-as-sustainable-carbon-source-for-lipid-accumulation-in-oleaginous-yeasts
#11
Lorenzo Signori, Diletta Ami, Riccardo Posteri, Andrea Giuzzi, Paolo Mereghetti, Danilo Porro, Paola Branduardi
BACKGROUND: Microbial lipids can represent a valuable alternative feedstock for biodiesel production in the context of a viable bio-based economy. This production can be driven by cultivating some oleaginous microorganisms on crude-glycerol, a 10% (w/w) by-product produced during the transesterification process from oils into biodiesel. Despite attractive, the perspective is still economically unsustainable, mainly because impurities in crude glycerol can negatively affect microbial performances...
May 5, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/26332293/treatment-failure-with-rhythm-and-rate-control-strategies-in-patients-with-atrial-fibrillation-and-congestive-heart-failure-an-af-chf-substudy
#12
MULTICENTER STUDY
Katia Dyrda, Denis Roy, Hugues Leduc, Mario Talajic, Lynne Warner Stevenson, Peter G Guerra, Jason Andrade, Marc Dubuc, Laurent Macle, Bernard Thibault, Lena Rivard, Paul Khairy
INTRODUCTION: Rate and rhythm control strategies for atrial fibrillation (AF) are not always effective or well tolerated in patients with congestive heart failure (CHF). We assessed reasons for treatment failure, associated characteristics, and effects on survival. METHODS AND RESULTS: A total of 1,376 patients enrolled in the AF-CHF trial were followed for 37  ±  19 months, 206 (15.0%) of whom failed initial therapy leading to crossover. Rhythm control was abandoned more frequently than rate control (21...
December 2015: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/26138654/altered-bile-acid-metabolome-in-patients-with-nonalcoholic-steatohepatitis
#13
COMPARATIVE STUDY
Brian C Ferslew, Guoxiang Xie, Curtis K Johnston, Mingming Su, Paul W Stewart, Wei Jia, Kim L R Brouwer, A Sidney Barritt
BACKGROUND AND AIMS: The prevalence of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the development and progression of NAFLD to NASH and cirrhosis is poorly understood. This study aimed to quantify the bile acid metabolome in healthy subjects and patients with non-cirrhotic NASH under fasting conditions and after a standardized meal. METHODS: Liquid chromatography tandem mass spectroscopy was used to quantify 30 serum and 16 urinary bile acids from 15 healthy volunteers and 7 patients with biopsy-confirmed NASH...
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26030301/implementation-research-to-inform-the-use-of-xpert-mtb-rif-in-primary-health-care-facilities-in-high-tb-and-hiv-settings-in-resource-constrained-settings
#14
Monde Muyoyeta, Maureen Moyo, Nkatya Kasese, Mapopa Ndhlovu, Deborah Milimo, Winfridah Mwanza, Nathan Kapata, Albertus Schaap, Peter Godfrey Faussett, Helen Ayles
BACKGROUND: The current cost of Xpert MTB RIF (Xpert) consumables is such that algorithms are needed to select which patients to prioritise for testing with Xpert. OBJECTIVE: To evaluate two algorithms for prioritisation of Xpert in primary health care settings in a high TB and HIV burden setting. METHOD: Consecutive, presumptive TB patients with a cough of any duration were offered either Xpert or Fluorescence microscopy (FM) test depending on their CXR score or HIV status...
2015: PloS One
https://www.readbyqxmd.com/read/25948378/a-patient-with-polymerase-e1-deficiency-pole1-clinical-features-and-overlap-with-dna-breakage-instability-syndromes
#15
Isabelle Thiffault, Carol Saunders, Janda Jenkins, Nikita Raje, Kristi Canty, Mukta Sharma, Lauren Grote, Holly I Welsh, Emily Farrow, Greyson Twist, Neil Miller, David Zwick, Lee Zellmer, Stephen F Kingsmore, Nicole P Safina
BACKGROUND: Chromosome instability syndromes are a group of inherited conditions associated with chromosomal instability and breakage, often leading to immunodeficiency, growth retardation and increased risk of malignancy. CASE PRESENTATION: We performed exome sequencing on a girl with a suspected chromosome instability syndrome that manifested as growth retardation, microcephaly, developmental delay, dysmorphic features, poikiloderma, immune deficiency with pancytopenia, and myelodysplasia...
2015: BMC Medical Genetics
https://www.readbyqxmd.com/read/25888414/the-acute-effect-of-beta-guanidinopropionic-acid-versus-creatine-or-placebo-in-healthy-men-abc-trial-study-protocol-for-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Fares A Karamat, Deborah L Horjus, Yentl C Haan, Lisa van der Woude, Inge Oudman, Gert A van Montfrans, Joseph F Clark, Lizzy M Brewster
BACKGROUND: Despite adequate treatment, up to 30% of treated antihypertensive patients with primary, uncomplicated hypertension remain uncontrolled. We proposed that high intracellular activity of the ATP regenerating enzyme creatine kinase (CK) increases pressor responses and hypertension risk. In line with this, we found that plasma CK activity after rest, a surrogate measure of tissue activity, is the main predictor of blood pressure levels and failure of antihypertensive therapy in the general population...
February 22, 2015: Trials
https://www.readbyqxmd.com/read/25778581/the-acute-effect-of-beta-guanidinopropionic-acid-versus-creatine-or-placebo-in-healthy-men-abc-trial-study-protocol-for-a-randomized-controlled-trial
#17
Fares A Karamat, Deborah L Horjus, Yentl C Haan, Lisa van der Woude, Inge Oudman, Gert A van Montfrans, Joseph F Clark, Lizzy M Brewster
BACKGROUND: Despite adequate treatment, up to 30% of treated antihypertensive patients with primary, uncomplicated hypertension remain uncontrolled. We proposed that high intracellular activity of the ATP regenerating enzyme creatine kinase (CK) increases pressor responses and hypertension risk. In line with this, we found that plasma CK activity after rest, a surrogate measure of tissue activity, is the main predictor of blood pressure levels and failure of antihypertensive therapy in the general population...
December 2015: Trials
https://www.readbyqxmd.com/read/25653700/impact-of-smoking-on-clinical-outcomes-in-female-patients-with-acute-myocardial-infarction
#18
Yun Ah Jeong, Myung Ho Jeong, Hae Chang Jeong, Youngkeun Ahn, Young Jo Kim, Chong Jin Kim, Myeong Chan Cho
BACKGROUND AND OBJECTIVES: Cigarette smoking has been recognized as a prominent threat to women's health. We investigated the impact of smoking on clinical outcomes in Korean female patients after acute myocardial infarction (AMI). SUBJECTS AND METHODS: Out of the AMI patients who enrolled in the Korea AMI Registry, 4444 female patients were included in this study. Patients were divided into two groups-non-smoker and smoker-according to their current smoking status...
January 2015: Korean Circulation Journal
https://www.readbyqxmd.com/read/25607136/in-fiber-torsion-sensor-based-on-dual-polarized-mach-zehnder-interference
#19
Lei Chen, Wei-Gang Zhang, Li Wang, Hao Zhang, Jonathan Sieg, Quan Zhou, Li-Yu Zhang, Biao Wang, Tie-Yi Yan
This paper presents a novel optical fiber torsion sensor based on dual polarized Mach-Zehnder interference (DPMZI). Unlike the conventional fiber sensor, the proposed sensor is composed of a sensor part and a demodulator. The demodulator is made by a bared single mode fiber (SMF) loop, and the sensor part is a segment of a coated SMF placed before the loop. A mathematical model is proposed based on DPMZI mechanism and from the model when the sensor part is twisted, the E-field rotational angle will bring a quasi-linear impact on the resonance dip wavelength in their matched detecting range...
December 29, 2014: Optics Express
https://www.readbyqxmd.com/read/25595919/technical-factors-associated-with-anastomotic-leak-after-roux-en-y-gastric-bypass
#20
MULTICENTER STUDY
Mark D Smith, Abidemi Adeniji, Abdus S Wahed, Emma Patterson, William Chapman, Anita P Courcoulas, Gregory Dakin, David Flum, Carol McCloskey, James E Mitchell, Alfons Pomp, Myrlene Staten, Bruce Wolfe
BACKGROUND: Anastomotic leak is one of the most serious complications after Roux-en-Y gastric bypass (RYGB). Our objective was to examine the relationship between technical factors and incidence of clinically relevant anastomotic leak after RYGB in longitudinal assessment of bariatric surgery (LABS). The setting of the study was 11 bariatric centers in the United States, university, and private practice. METHODS: Patient characteristics, technical factors of surgery, and postoperative outcomes were assessed by trained researchers using standardized protocols...
March 2015: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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