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Hiroyuki Kurabeishi, Ryu Tatsuo, Nezu Makoto, Fukui Kazunori
BACKGROUND: During childhood, perioral muscle function is closely associated with malocclusion. OBJECTIVE: To clarify effects of tongue function on maxillofacial morphology in children, tongue pressure and maximum lip-closing force (LCF) were measured and the relationship between perioral muscle function and maxillofacial morphology were evaluated according to skeletal classification. METHODS: Maximum tongue pressure (MTP) and swallowing tongue pressure (STP) were measured on the anterior palatine rugae in 100 children (Hellman's dental stages IIIA-IIIC) using a balloon-type tongue-pressure-measurement device...
June 16, 2018: Journal of Oral Rehabilitation
Felipe L Lopez, Punam Mistry, Hannah K Batchelor, Joanne Bennett, Alastair Coupe, Terry B Ernest, Mine Orlu, Catherine Tuleu
Patient acceptability is an important consideration in the design of medicines for children. The aim of this study was to investigate acceptability of multiparticulates in healthy children and adults. A randomised, single-blind acceptability testing was performed involving 71 children (4-12 years) and 61 adults (18-37 years). Each participant received three 500 mg samples of microcrystalline cellulose pellets administered on a medicine spoon with water at 5-10 minutes intervals. Acceptability was measured based on voluntary intake of the samples, facial expressions, ratings on hedonic scales and reported willingness to take multiparticulates everyday as a medicine...
June 15, 2018: Scientific Reports
Sumadi Lukman Anwar, Guritno Adistyawan, Wahyu Wulaningsih, Christoph Gutenbrunner, Boya Nugraha
Cancer diagnosis often substantially affects patient's physical, psychological, and emotional status. The majority of cancer patients experience declining of energy, activity levels, social-cultural participation and relationships. In addition, cancer progression and side effects of aggressive cancer treatment often cause debilitating pain, fatigue, weakness, joint stiffness, depression, emotional instability, limited mobility, poor nutritional status, skin breakdown, bowel dysfunction, swallowing difficulty, and lymphedema leading into functional impairment and disability that can be addressed through rehabilitation care...
June 13, 2018: American Journal of Physical Medicine & Rehabilitation
Koji Hara, Haruka Tohara, Kenichiro Kobayashi, Kohei Yamaguchi, Kanako Yoshimi, Ayako Nakane, Shunsuke Minakuchi
Swallowing muscle strength weakens with aging. Although numerous studies have investigated tongue pressure (TP) changes with age, studies on jaw-opening force (JOF), an indicator of suprahyoid muscle strength, are lacking. We investigated differences between age-related declines in TP and JOF in a cross-sectional study of 980 healthy and independent participants (379 men, 601 women) without dysphagia. Hand grip strength (HGS), TP, and JOF were compared among decade-based age groups in multiple comparison analyses with post-hoc tests and effect size calculated...
May 31, 2018: Archives of Gerontology and Geriatrics
Thomas Greuter, Ekaterina Safroneeva, Christian Bussmann, Luc Biedermann, Stephan R Vavricka, David A Katzka, Alain M Schoepfer, Alex Straumann
BACKGROUND & AIMS: Although swallowed topical corticosteroids (STCs) are effective in inducing remission of active eosinophilic esophagitis (EoE), there are few data on maintenance of long-term remission. We evaluated the long-term effectiveness of STC therapy for adults with EoE. METHODS: We performed a retrospective study using the Swiss EoE database. We analyzed data on 229 patients with EoE treated with STCs (175 male; mean age at diagnosis, 39±15 years; median time until diagnosis, 6 years) from 2000 through 2014...
June 11, 2018: Clinical Gastroenterology and Hepatology
Chunhui Zheng, Xiaomei Chen, Fangbiao Zhang, Liping Yan, Xiangyan Zhang
RATIONALE: Primary mucoepidermoid carcinoma (MEC) of the esophagus is a rare type of malignant neoplasm. Its morphology resembles that of MEC of the salivary glands. It is characterized by a diffuse mixture of squamous and mucus-secreting glandular carcinoma cells. Due to the low incidence of esophageal MEC, the biological behavior and treatment of this tumor have not been well studied. PATIENT CONCERNS: In this case report, we describe a case of a 59-year-old man who presented with difficulty in swallowing...
June 2018: Medicine (Baltimore)
Kiera N Berggren, Man Hung, Melissa M Dixon, Jerry Bounsanga, Becky Crockett, Mary D Foye, Yushan Gu, Craig Campbell, Russell J Butterfield, Nicholas E Johnson
INTRODUCTION: We describe an exploratory study of orofacial function in children with congenital myotonic dystrophy (CDM) versus healthy controls. METHODS: We evaluated 41 children with CDM and 29 healthy controls for speech and swallow function and for lingual and labial strength. RESULTS: The Iowa Oral Performance Instrument (IOPI), measuring tongue strength, and a lip force meter (LFM), measuring lip strength, had excellent inter-rater reliability with ICCs of 0...
June 14, 2018: Muscle & Nerve
Belén Rocío Imperiale, Cecilia Nieves, Belén Mancino, Myriam Sanjurjo, Silvina Tártara, Ángela Beatríz Di Giulio, Juan Carlos Palomino, Nora Susana Morcillo, Anandi Martin
Background: There is a critical need to improve the diagnostic accuracy of tuberculosis (TB) in children. Several techniques have been developed to improve the quality of sputum samples; however, these procedures are very unpleasant and invasive and require hospitalization and trained personnel. This study aims to explore the potential use of a new and noninvasive tool, "string test," for TB diagnosis in children and in adults not able to render sputum samples and at risk of developing multidrug-resistant TB (MDR-TB)...
April 2018: International Journal of Mycobacteriology
Michaela Wagner-Menghin, Alexander Hirsch, Peter Pokieser
The problems and symptoms of patients are at the heart of medicine and pertinent to information, communication, and education. Patients present their problems to health professionals looking for relief and a cure, while institutions collect data about symptoms of patients and the way health professionals treated them to support society's care providers in administrating and managing care. The information on the problems of patients and the way health professionals treated them, which is gathered and stored in patient files, is valuable as educational material in the field of medicine...
June 13, 2018: Annals of the New York Academy of Sciences
Luis F Tintinago, William Victoria, Estephania Candelo, Juan Camilo Diaz, Juan Carlos Arce, Luis Miguel Aristizabal, Claudia Sanz, Maria Claudia Montes, Maria A Velez-Esquivia
INTRODUCTION: Bilateral vocal folds' immobility is a challenge in laryngology. Multiple procedures have been proposed to improve breathing by statically enlarging the glottal airway, what also results in loss of voice and aspiration. We proposed a technique to enlarge the posterior glottis by rotating the arytenoids on its axis, imitating the function of the posterior cricoarytenoid muscle, with the objective of evaluating the results regarding decannulation, voice quality, and bronchoaspiration...
June 5, 2018: American Journal of Otolaryngology
Diéllen Albanio Wegner, Eduardo Matias Dos Santos Steidl, Adriane Schmidt Pasqualoto, Renata Mancopes
PURPOSE: Describe efficacy and safety of deglutition, nutritional risk, and quality of life in deglutition, and associate nutritional risk with quality of life in individuals with chronic pulmonary disease. METHODS: The participants were 17 individuals with chronic pulmonary disease evaluated using the following instruments: Volume-Viscosity Swallow Test (V-VST), Quality of Life in Swallowing Disorders (SWAL-QOL) questionnaire, Mini Nutritional Assessment (MNA), and body mass index (BMI)...
June 11, 2018: CoDAS
Meredith C Miles, Maren N Vitousek, Jerry F Husak, Michele A Johnson, Lynn B Martin, Conor C Taff, Cedric Zimmer, Matthew B Lovern, Matthew J Fuxjager
Circulating steroid hormone levels exhibit high variation both within and between individuals, leading some to hypothesize that these phenotypes are more variable than other morphological, physiological, and behavioral traits. This should have profound implications for the evolution of steroid signaling systems, but few studies have examined how endocrine variation compares to that of other traits or differs among populations. Here we provide such an analysis by first exploring how variation in three measures of corticosterone (CORT)- baseline, stress-induced, and post-dexamethasone injection- compares to key traits characterizing morphology (wing length, mass), physiology (reactive oxygen metabolite concentration [d-ROMs] and antioxidant capacity), and behavior (provisioning rate) in two populations of tree swallow (Tachycineta bicolor)...
June 12, 2018: Integrative and Comparative Biology
Sung-Hwan Eom, Yong-Gi Chun, Chan-Eun Park, Bum-Keun Kim, Sang-Hoon Lee, Dong-June Park
The aims of this study were to determine the viability of using freeze-thaw infusion technology to produce a range of root vegetables using enzyme treatments with improved texture characteristics for elderly consumers with swallowing difficulties. We applied enzyme impregnation as a technology to soften the textures of root vegetables commonly consumed in Korea; balloon flower root (Platycodon grandiflorus), burdock root (Arctium lappa L.), carrot (Daucus carota L), and lotus root (Nelumbo nucifera Gaertn) through use of a texture analyzer after the freeze-thaw infusion of a commercial enzyme...
June 13, 2018: Journal of Texture Studies
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Nature
O H Jong-Chi
Aging causes motor function deterioration in the elderly population, which in turn can cause weakness in the muscles associated with swallowing. Swallowing-related problems in elderly individuals can be prevented or their symptoms can be improved with strengthening exercises for the muscles involved in swallowing. The existing strengthening exercises for the suprahyoid muscle have their limitations. Therefore, it is necessary to find another exercise that can be performed by individuals whose personal characteristics make it difficult for them to perform the existing exercises...
June 9, 2018: Experimental Gerontology
Sonja M Molfenter, Danielle Brates, Erica Herzberg, Mehak Noorani, Cathy Lazarus
Purpose: It has been widely reported that a proportion of healthy, community-dwelling seniors will develop dysphagia in the absence of a known neurological, neuromuscular, or structural cause. Our objective was to test whether various feasible, noninvasive measures of swallowing could differentiate safe versus unsafe and efficient versus inefficient swallowing on videofluoroscopy (VF) in a sample of healthy seniors. Method: VFs from 44 (21 male, 23 female) healthy community-dwelling seniors (> 65 years old) were compared with a series of feasible, noninvasive swallowing metrics: maximal tongue strength (anterior and posterior), hand grip strength, pharyngeal volume, age, body mass index, 3-oz water swallow challenge, the 10-item Eating Assessment Tool questionnaire, and the Frailty Index...
June 11, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
Naveen B Shivanand, Mihir T Mohan, Shawn T Joseph
Reconstruction of floor of the mouth and ventral surface of the tongue defects can be challenging because inadequate correction can lead to mobility restriction of the tongue and resultant impairment of speech and swallowing. Ideal flap should be pliable, provide adequate bulk, be easy to harvest, and cosmetically acceptable. Commonly used ipsilateral facial artery-based myomucosal flaps may not be ideal if facial vessels need resection. We share our experience in a case of simultaneous primary mucoepidermoid carcinoma of right submandibular and sublingual glands, with a postsurgical defect involving floor of the mouth and ventral surface of the tongue, reconstructed with islanded facial artery myomucosal flap raised from left buccal mucosa and tunneled into the right floor of the mouth defect medial to mandible...
June 2018: Craniomaxillofacial Trauma & Reconstruction
Prasad G Iyer, William R Taylor, Michele L Johnson, Ramona L Lansing, Kristyn A Maixner, Tracy C Yab, Julie A Simonson, Mary E Devens, Seth W Slettedahl, Douglas W Mahoney, Calise K Berger, Patrick H Foote, Thomas C Smyrk, Kenneth K Wang, Herbert C Wolfsen, David A Ahlquist
BACKGROUND: Minimally invasive methods have been described to detect Barrett's esophagus (BE), but are limited by subjectivity and suboptimal accuracy. We identified methylated DNA markers (MDMs) for BE in tissue and assessed their accuracy on whole esophagus brushings and capsule sponge samples. METHODS: Step 1: Unbiased whole methylome sequencing was performed on DNA from BE and normal squamous esophagus (SE) tissue. Discriminant MDM candidates were validated on an independent patient cohort (62 BE cases, 30 controls) by quantitative methylation specific PCR (qMSP)...
June 12, 2018: American Journal of Gastroenterology
Liciane P Valarelli, Anne M B Corradi, Thaís H Grechi, Alan L Eckeli, Davi C Aragon, Daniel S Küpper, Leila A Almeida, Heidi H Sander, Cláudia M de Felício, Luciana V V Trawitzki, Fabiana C P Valera
BACKGROUND: Obstructive Sleep Apnea Syndrome (OSAS) is believed to be associated with craniofacial and neuromuscular changes, although the interplay among these variables still is poorly recognized. OBJECTIVE: to identify hyoid, muscular and swallowing changes associated with OSAS, and to correlate these alterations with OSAS severity. METHODS: Cross-sectional study, in a tertiary referral center. Seventy-two adult individuals participated in this study: 12 controls (without apnea) and 60 patients with apnea (mild, moderate and severe OSAS - 20 individuals in each group)...
June 11, 2018: Journal of Oral Rehabilitation
A N Ahn, N Konow, C Tijs, A A Biewener
To relate in vivo behavior of fascicle segments within a muscle to their in vitro force-length relationships, we examined the strain behavior of paired segments within each of three vertebrate muscles. After determining in vivo muscle activity patterns and length changes of in-series segments within the semimembranosus muscle in the American Toad (Bufo americanus) during hopping and within the sternohyoid muscle in the rat (Rattus rattus) during swallowing, and of spatially separated fascicles within the medial gastrocnemius muscle in the rat during trotting, we measured their corresponding in vitro (toad) or in situ (rat) force-length relationships...
June 7, 2018: Integrative and Comparative Biology
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