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https://www.readbyqxmd.com/read/28830137/clinical-applications-of-interferon-%C3%AE-releasing-assays-for-cytomegalovirus-to-differentiate-cytomegalovirus-disease-from-bystander-activation-a-pilot-proof-of-concept-study
#1
Sung-Han Kim, Ho-Su Lee, Hyun-Jung Lee, Sun-Mi Kim, Sung Shin, Sang-Hyoung Park, Kyung-Jo Kim, Young-Hoon Kim, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Suk-Kyun Yang, Yang Soo Kim, Jun Hee Woo, Duck-Jong Han
Background/Aims: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models. Methods: We prospectively enrolled all human immunodeficiency virus non-infected patients with confirmed Pneumocystitis jirovecii pneumonia (PCP) and those with suspected gastrointestinal CMV disease in a tertiary hospital. All patients underwent CMV interferon-γ releasing assay (IGRA) for CMV (T-track CMV, Lophius Biosciences)...
August 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28830136/-the-diagnosis-of-metastatic-malignant-melanoma-incidentally-found-during-a-national-health-screening-endoscopy-a-case-report
#2
Jeong Seok Lee, Su Jin Kim, Dae Hwan Kang, Hyung Wook Kim, Cheol Woong Choi, Su Bum Park, Chang Woo Yeo, Hyeong Jin Kim
Malignant melanoma is one of the most common malignant diseases of the gastrointestinal tract. It has been reported that the malignant melanoma metastasizes not only to the small intestine due to the abundant blood supply, but also to the stomach, colon, and esophagus. Gastrointestinal metastasis is usually suspected depending on the clinical symptoms, as well as based on radiological or endoscopic findings. Imunohistochemical stains, such as Melan-A/Melanoma antigen recognized by T cell-1 or human melanoma black-45, are useful for confirming the diagnosis of malignant melanoma...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830135/clinical-interpretation-of-elevated-ca-19-9-levels-in-obstructive-jaundice-following-benign-and-malignant-pancreatobiliary-disease
#3
Min Seong Kim, Tae Joo Jeon, Ji Young Park, Jeongmin Choi, Won Chang Shin, Seong Eun Park, Ji Young Seo, Young Moon Kim
Background/Aims: Elevated carbohydrate antigen (CA) 19-9 level may be unable to differentiate between benign and malignant pancreatobiliary disease with obstructive jaundice. The study aims to determine the clinical interpretation and the diagnostic value of CA 19-9 level in pancreatobiliary diseases with coexistent obstructive jaundice. Methods: We retrospectively reviewed the data of 981 patients who underwent biliary drainage due to obstructive jaundice following pancreatobiliary disease at Sanggye Paik Hospital for 5 years...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830132/-the-efficacy-of-moxifloxacin-containing-triple-therapy-after-hybrid-therapy-failure-in-helicobacter-pylori-eradication
#4
Soohoon Kwon, Dong Ho Lee, Jae Bin Kang, Nayoung Kim, Young Soo Park, Cheol Min Shin, Hyuk Yoon, Yoon Jin Choi
Background/Aims: Hybrid therapy was successful in eradicating Helicobacter pylori (H. pylori) according to previous reports. However, to the best of our knowledge, there have only been a few studies evaluating the optimal choice after hybrid failure. Hence, we aimed to evaluate the efficacy of moxifloxacin-containing triple therapy after hybrid therapy failure in H. pylori eradication. Methods: Between January 2013 and March 2016, we retrospectively reviewed patients who underwent failed hybrid therapy, as first line treatment, in eradicating H...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830131/-pharmacotherapy-in-patients-with-chronic-constipation
#5
REVIEW
Sang Jin Kim, Kyung Sik Park
Chronic constipation is one of the most common digestive diseases frequently observed in a clinical setting. It has been known to cause considerable damage to the quality of life of patients. Despite recent developments, there are considerable limitations in the use of constipation-modulating agents in Korea. Chloride channel inhibitors, such as lubiprostone and linaclotide, have not been introduced in Korea yet, and prucalopride and several kinds of polyethylene glycol are not covered under medical insurance...
August 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28830112/infectious-disease-surveillance-in-the-big-data-era-towards-faster-and-locally-relevant-systems
#6
Lone Simonsen, Julia R Gog, Don Olson, Cécile Viboud
While big data have proven immensely useful in fields such as marketing and earth sciences, public health is still relying on more traditional surveillance systems and awaiting the fruits of a big data revolution. A new generation of big data surveillance systems is needed to achieve rapid, flexible, and local tracking of infectious diseases, especially for emerging pathogens. In this opinion piece, we reflect on the long and distinguished history of disease surveillance and discuss recent developments related to use of big data...
December 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28830111/epidemic-forecasting-is-messier-than-weather-forecasting-the-role-of-human-behavior-and-internet-data-streams-in-epidemic-forecast
#7
Kelly R Moran, Geoffrey Fairchild, Nicholas Generous, Kyle Hickmann, Dave Osthus, Reid Priedhorsky, James Hyman, Sara Y Del Valle
Mathematical models, such as those that forecast the spread of epidemics or predict the weather, must overcome the challenges of integrating incomplete and inaccurate data in computer simulations, estimating the probability of multiple possible scenarios, incorporating changes in human behavior and/or the pathogen, and environmental factors. In the past 3 decades, the weather forecasting community has made significant advances in data collection, assimilating heterogeneous data steams into models and communicating the uncertainty of their predictions to the general public...
December 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28830078/reproducing-epidemiologic-research-and-ensuring-transparency
#8
Steven S Coughlin
Measures for ensuring that epidemiologic studies are reproducible include making data sets and software available to other researchers so they can verify published findings, conduct alternative analyses of the data, and check for statistical errors or programming errors. Recent developments related to the reproducibility and transparency of epidemiologic studies include the creation of a global platform for sharing data from clinical trials and the anticipated future extension of the global platform to non-clinical trial data...
August 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28830074/do-antimicrobial-mass-medications-work-a-systematic-review-and-meta-analysis-of-randomised-clinical-trials-investigating-antimicrobial-prophylaxis-or-metaphylaxis-against-naturally-occurring-bovine-respiratory-disease
#9
Keith Edward Baptiste, Niels Christian Kyvsgaard
A distinct difference between veterinary and human medicine is the routine use of antimicrobial mass medications (prophylaxis, metaphylaxis) to healthy individuals. The need for antimicrobial mass medications is based on beliefs that group/s of animals will contract a bacterial disease (i.e. morbidity) and/or die (i.e. mortality). Bovine respiratory disease (BRD) represents the major indication for cattle antimicrobials worldwide. The objectives were to perform a systematic review and meta-analysis of randomised controlled clinical trials (RCTs) for naturally occurring BRD investigating antimicrobial prophylaxis/metaphylaxis to prevent morbidity/mortality...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28830068/cytokine-production-in-vitro-and-in-rat-model-of-colitis-in-response-to-lactobacillus-plantarum-ls-07
#10
Jana Štofilová, Tomaž Langerholc, Cristian Botta, Primož Treven, Lidija Gradišnik, Rastislav Salaj, Alena Šoltésová, Izabela Bertková, Zdenka Hertelyová, Alojz Bomba
Over the past decade, it has become clear that specific probiotic lactobacilli are valuable in the prevention and treatment of infectious and inflammatory diseases of gastrointestinal tract but their successful application would benefit greatly from a better understanding of the mechanisms of individual strains. Hence, each probiotic strain should be characterized for their immune activity before being proposed for clinical applications. The aim of the study was to characterize the immunomodulatory activity of the strain Lactobacillus (L...
August 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28830061/simultaneous-determination-and-pharmacokinetics-of-danshensu-protocatechuic-aldehyde-4-hydroxy-3-methyloxyphenyl-lactic-acid-and-protocatechuic-acid-in-human-plasma-by-lc-ms-ms-after-oral-administration-of-compound-danshen-dripping-pills
#11
Wei Li, Hongjie Zhou, Yang Chu, Xiangyang Wang, Ruizhi Luo, Liu Yang, Navaneethakrishnan Polachi, Xiao Li, Min Chen, Luqi Huang, Xueying Yan, Zhixin Guo, He Sun
Compound Danshen Dripping Pills (CDDP), a herbal patent medicine, is widely used in China for the prevention and treatment of cardiovascular diseases. A simple, sensitive and reliable method for simultaneous determination of danshensu (DSS), protocatechuic aldehyde (PCA), and their related metabolites, 4-hydroxy-3-methyloxyphenyl lactic acid (HMLA) and protocatechuic acid (PAA) in human plasma was developed and validated based on liquid chromatography tandem mass spectrometry (LC-MS/MS). The analytes and internal standard (IS), vanillic acid (VAA), were extracted from plasma with ethyl acetate and separated on a C18 column by using the mobile phase consisted of methanol-0...
July 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28830030/multivariate-trajectories-across-multiple-domains-of-health-related-quality-of-life-in-children-with-new-onset-epilepsy
#12
Tolulope T Sajobi, Meng Wang, Mark A Ferro, Anita Brobbey, Shane Goodwin, Kathy N Speechley, Samuel Wiebe
The diagnosis of epilepsy in children is known to impact the trajectory of their health-related quality of life (HRQOL) over time. However, there is limited knowledge about variations in longitudinal trajectories across multiple domains of HRQOL. This study aims to characterize the heterogeneity in HRQOL trajectories across multiple HRQOL domains and to evaluate predictors of differences among the identified trajectory groups in children with new-onset epilepsy. Data were obtained from the Health Related Quality of Life in Children with Epilepsy Study (HERQULES), a prospective multi-center study of 373 children newly diagnosed with new-onset epilepsy who were followed up over 2years...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28830029/persistent-uncrossed-corticospinal-connections-in-patients-with-intractable-focal-epilepsy
#13
Harper L Kaye, Roman Gersner, Aaron D Boes, Alvaro Pascual-Leone, Alexander Rotenberg
Corticospinal connections may be bilateral at birth, but a predominantly unilateral and crossed pattern develops by the toddler years. Acquired injury can alter the normal development of laterality such that uncrossed corticospinal connections persist, particularly if the injury is early in life and involves the motor system. Whether other developmental insults, such as childhood epilepsy, affect the development of crossed laterality in the motor system is unknown, although this topic has relevance for understanding the broader impact of epilepsy on brain development...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28830027/factors-influencing-use-of-family-planning-in-women-living-in-crisis-affected-areas-of-sub-saharan-africa-a-review-of-the-literature
#14
REVIEW
Kelly Ackerson, Ruth Zielinski
BACKGROUND: far too many women continue to die from pregnancy and childbirth related causes. While rates have decreased in the past two decades, some areas of the world such as sub-Saharan Africa continue to have very high maternal mortality rates. One intervention that has been demonstrated to decrease maternal mortality is use of family planning and modern contraception, yet rates of use in sub-Saharan countries with the highest rates of maternal death remain very low. AIM: to review available research and summarize the factors that inhibit or promote family planning and contraceptive use among refugee women and women from surrounding areas living in Sub-Saharan Africa...
August 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28830009/humanization-of-jaa-f11-a-highly-specific-anti-thomsen-friedenreich-pancarcinoma-antibody-and-invitro-efficacy-analysis
#15
Swetha Tati, John C Fisk, Julia Abdullah, Loukia Karacosta, Taylor Chrisikos, Padraic Philbin, Susan Morey, Diala Ghazal, Fatma Zazala, Joseph Jessee, Sally Quataert, Stephen Koury, David Moreno, Jing Ying Eng, Vladislav V Glinsky, Olga V Glinskii, Muctarr Sesay, Anthony W Gebhard, Karamveer Birthare, James R Olson, Kate Rittenhouse-Olson
JAA-F11 is a highly specific mouse monoclonal to the Thomsen-Friedenreich Antigen (TF-Ag) which is an alpha-O-linked disaccharide antigen on the surface of ~80% of human carcinomas, including breast, lung, colon, bladder, ovarian, and prostate cancers, and is cryptic on normal cells. JAA-F11 has potential, when humanized, for cancer immunotherapy for multiple cancer types. Humanization of JAA-F11, was performed utilizing complementarity determining regions grafting on a homology framework. The objective herein is to test the specificity, affinity and biology efficacy of the humanized JAA-F11 (hJAA-F11)...
August 19, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28829990/interlaboratory-variability-of-ki67-staining-in-breast-cancer
#16
Cornelia M Focke, Horst Bürger, Paul J van Diest, Kai Finsterbusch, Doreen Gläser, Eberhard Korsching, Thomas Decker
BACKGROUND: Postanalytic issues of Ki67 assessment in breast cancers like counting method standardisation and interrater bias have been subject of various studies, but little is known about analytic variability of Ki67 staining between pathology labs. Our aim was to study interlaboratory variability of Ki67 staining in breast cancer using tissue microarrays (TMAs) and central assessment to minimise preanalytic and postanalytic influences. METHODS: Thirty European pathology labs stained serial slides of a TMA set of breast cancer tissues with Ki67 according to their routine in-house protocol...
August 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28829986/neurobiology-of-autoimmune-encephalitis
#17
REVIEW
Masaki Fukata, Norihiko Yokoi, Yuko Fukata
Autoimmune encephalitis presenting with amnesia, seizures, and psychosis is highly topical in basic and clinical neuroscience. Recent studies have identified numerous associated autoantibodies, targeting cell-surface synaptic proteins including neurotransmitter receptors (e.g. NMDA receptors (NMDARs)) and a secreted protein, LGI1. In vitro and in vivo analyses of the influence of the autoantibodies have begun to clarify their causal roles. Of particular interest is the generation of recombinant monoclonal antibodies from patients' B cells with anti-NMDAR encephalitis...
August 19, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28829979/clinical-and-demographic-predictors-of-response-to-rtms-treatment-in-unipolar-and-bipolar-depressive-disorders
#18
Reza Rostami, Reza Kazemi, Michael A Nitsche, Fatemeh Gholipour, M A Salehinejad
OBJECTIVE: Previous studies investigated predictors of repetitive transcranial magnetic stimulation (rTMS) response in depressive disorders but there is still limited knowledge about clinical predictors. Moreover, predictors of rTMS response in bipolar depression (BDD) are less studied than unipolar depression (UDD). METHODS: We performed a binary logistic regression analysis in 248 patients with depressive disorders (unipolar N=102, bipolar N=146) who received 20 sessions of DLPFC rTMS (High-frequency rTMS, low-frequency rTMS, bilateral rTMS) to investigate significant clinical and demographic predictors of rTMS response...
July 24, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28829978/spatial-constraints-evoke-increased-number-of-steps-during-turning-in-parkinson-s-disease
#19
Urban M Fietzek, Lisa Stuhlinger, Annika Plate, Andres Ceballos-Baumann, Kai Bötzel
OBJECTIVE: Turning and limitations to step length were shown to trigger progressive shortening of steps, which can lead to freezing of gait. By reducing the base area in which the turn had to take place, we aimed to evaluate the contribution of spatial constraints on 360° axial turns in people with Parkinson's disease with and without freezing. METHODS: We evaluated 40 patients with and without freezing and 16 age-matched healthy subjects. We assessed clinical data, and used body-worn inertial sensors to describe stepping and turn duration of 360° in quadratic squares of different sizes marked on the floor...
July 25, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28829973/feasibility-and-efficacy-of-repeated-hysteroscopic-cesarean-niche-resection
#20
Shlomo B Cohen, Roy Mashiach, Alexandra Baron, Motti Goldenberg, Eyal Schiff, Raoul Orvieto, Jerome Bouaziz
OBJECTIVE: Cesarean-induced niche can cause symptoms such as abnormal postmenstrual bleeding, pain and associated infertility. Hysteroscopic niche resection is usually a successful treatment, but can result in a failure to improve symptoms or symptoms can recur. In the present study we aim to evaluate the feasibility, effectiveness, and safety of a second hysteroscopic niche resection for patients in whom an initial hysteroscopic resection failed to improve symptoms. STUDY DESIGN: This retrospective cohort study (Canadian Task Force classification II-2) hospital tell hashomer (tertiary center) included all patients who underwent a second hysteroscopic niche resection between 2011 and 2015...
August 12, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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