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https://www.readbyqxmd.com/read/29454299/congenital-forms-of-diabetes-the-beta-cell-and-beyond
#1
REVIEW
Lisa R Letourneau, Siri Atma W Greeley
The majority of patients diagnosed with diabetes less than 6 months of age, and many cases diagnosed between 6 and 12 months of age, have a gene mutation that causes permanent or transient hyperglycemia. Recent research advances have allowed for the discovery of new causes of congenital diabetes, including genes involved in pancreatic development (GATA4, NKX2-2, MNX1) and monogenic causes of autoimmune dysregulation (STAT3, LRBA). Ongoing follow-up of patients with KCNJ11 and ABCC8 mutations has supported the safety and efficacy of sulfonylureas, as well as the use of insulin pumps and continuous glucose monitors in infants with insulin-requiring forms of monogenic diabetes...
February 14, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29454298/is-the-biparietal-diameter-of-fetuses-in-late-gestation-too-variable-to-predict-readiness-for-cesarean-section-in-dogs
#2
K G M De Cramer, J O Nöthling
Correct assessment of readiness for cesarean section is essential for timing elective cesarean section during late pregnancy in the bitch. In humans, biparietal diameter is sufficiently precise and accurate and used in a clinical setting daily. The objectives of this study were to determine whether fetal biparietal diameter in late gestation in the dog could be used to predict readiness for cesarean section by having reached a minimum cut-off value and to correlate the biparietal diameter to birth weight. The biparietal diameter of 208 puppies in 34 litters from 31 English bulldog bitches and 660 puppies in 78 litters from 70 Boerboel bitches were measured immediately after delivery by cesarean section, performed at full term, using digital calipers...
February 10, 2018: Theriogenology
https://www.readbyqxmd.com/read/29454293/health-professions-faculty-beliefs-confidence-use-and-perceptions-of-organizational-culture-and-readiness-for-ebp-a-cross-sectional-descriptive-survey
#3
Kerry A Milner, Holly B Bradley, Tammy Lampley
BACKGROUND: Evidence-based practice (EBP) is an essential skill and ethical obligation for all practicing health professions clinicians because of its strong association with improved health outcomes. Emerging evidence suggests that faculty who prepare these clinicians lack proficiency to teach EBP. OBJECTIVES: The purpose of this study was to describe; 1) health profession faculty beliefs about and confidence in their ability to teach and implement EBP, 2) use of EBP for education, 3) organizational culture and readiness for EBP; and to determine whether relationships exist among these variables...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454292/the-nursification-of-a-bioscience-unit-and-its-impact-on-student-satisfaction-and-learning-in-an-undergraduate-nursing-degree
#4
Sheila Mortimer-Jones, Catherine Fetherston
Undergraduate nursing students traditionally find bioscience difficult, which can be compounded by an inability to relate bioscience theory to nursing practice. Subsequently, many registered nurses feel they lack knowledge in this area. Several studies have identified this problem and focused on the importance of linking bioscience theory in undergraduate nursing curricula to clinical practice. The aim of this study was to assess whether nursification (the active association of a subject with nursing theory and practice) of the bioscience content of a first year, first semester unit impacts on the students' learning experience...
February 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29454289/walking-speed-measurement-with-an-ambient-measurement-system-ams-in-patients-with-multiple-sclerosis-and-walking-impairment
#5
Francois Bethoux, Jonathan S Varsanik, Timothy W Chevalier, Elkan F Halpern, Darlene Stough, Zebadiah M Kimmel
BACKGROUND: Walking speed is an important measure of gait impairment in multiple sclerosis (MS). The clinical assessment of walking speed requires dedicated time, space, and personnel, and may not accurately gauge real-world performance. The term "Ambient Measurement System" (AMS) refers to a new class of device that passively measures walking speed at home, without the need for dedicated space or specialized setup. This study compared an AMS, Echo5D, versus in-clinic standard measures of walking speed on a straight path...
February 8, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29454279/bonding-of-composite-cements-to-zirconia-a-systematic-review-and-meta-analysis-of-in-vitro-studies
#6
REVIEW
Putsadeeporn Thammajaruk, Masanao Inokoshi, Shanley Chong, Massimiliano Guazzato
OBJECTIVES: The aim of this study was to systematically review the literature and statistically analyze bond strength data to identify the influence that composite cements, type of test methodology, chemical and mechanical pre-treatments have on the bond strength of composite cements to zirconia in three different artificial aging conditions. METHODS: The literature was electronically searched in MEDLINE, PUBMED, EMBASE, and SCOPUS to select relevant articles that evaluated the bond strength between zirconia and composite cements...
February 8, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29454275/long-term-follow-up-of-patients-undergoing-tibialis-posterior-transfer-is-acquired-pes-planus-a-complication
#7
Mira Pecheva, Adam Devany, Basil Nourallah, Steven Cutts, Chandra Pasapula
In this retrospective study, a series of 10 elective patients treated with transfer of the tibialis posterior (TP) tendon for pes cavus and drop foot are described. Since TP transfer completely subtracts the role of this tendon, this cohort of patients provides an opportunity to examine the consequences of tibialis posterior (TP) deficiency. After a mean follow up period of 44.7 months, only one patient showed evidence of strain in the spring ligament but none of the patients in this series developed clinical or radiological evidence of planovalgus deformity...
November 22, 2017: Foot
https://www.readbyqxmd.com/read/29454252/human-papillomavirus-detection-using-pcr-and-atr-ftir-for-cervical-cancer-screening
#8
Taciana Rymsza, Eliane Aline Ribeiro, Luis Felipe das Chagas E Silva de Carvalho, Tanmoy Bhattacharjee, Renata de Azevedo Canevari
The human papillomavirus (HPV) genital infection is considered one of the most common sexually transmitted diseases worldwide, and has been associated with cervical cancer. The objective of this study was to investigate the efficacy of the diagnostic methods: polymerase chain reaction (PCR) and Fourier transform infrared (FTIR) equipped with an ATR (Attenuated Total Reflectance) unit (Pike Tech) spectroscopy, to diagnose HPV infection in women undergoing gynecological examination. Seventeen patients (41.46%) of the 41 patients analyzed were diagnosed with exophytic/condyloma acuminate lesions by clinical analysis, 29 patients (70...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454237/liposomes-of-dimeric-artesunate-phospholipid-a-combination-of-dimerization-and-self-assembly-to-combat-malaria
#9
Muhammad Ismail, Longbing Ling, Yawei Du, Chen Yao, Xinsong Li
Artemisinin and its derivatives are highly effective drugs in the treatment of P. falciparum malaria. However, their clinical applications face challenges because of short half-life, poor bioavailability and growing drug resistance. In this article, novel dimeric artesunate phospholipid (Di-ART-GPC) based liposomes were developed by combination of dimerization and self-assembly to address these shortcomings. Firstly, Di-ART-GPC conjugate was synthesized by a facile esterification of artesunate (ART) and glycerophosphorylcholine (GPC) and confirmed by MS, 1 H NMR and 13 C NMR...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#10
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454226/dysphagia-and-laryngeal-pathology-in-post-surgical-cardiothoracic-patients
#11
Anna Miles, Naomi McLellan, Rochelle Machan, David Vokes, Alexandra Hunting, Mary McFarlane, Jennifer Holmes, Kelly Lynn
PURPOSE: Cardiothoracic surgery is known to result in dysphagia and laryngeal injury. While prevalence has been explored, extent, trajectory and longevity of symptoms are poorly understood. This retrospective, observational study explored dysphagia and laryngeal injury in patients following cardiothoracic surgery referred for instrumental swallowing assessment. METHODS: Clinical notes and endoscopic recordings of 106 patients (age range 18-87yrs; mean 63yrs; SD 15yrs) (including 190 endoscopes) at one large tertiary centre were reviewed by two speech-language pathologists and a laryngologist...
February 9, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29454195/chrna4-variant-causes-paroxysmal-kinesigenic-dyskinesia-and-genetic-epilepsy-with-febrile-seizures-plus
#12
Yong-Li Jiang, Fang Yuan, Ying Yang, Xiao-Long Sun, Lu Song, Wen Jiang
PURPOSE: Paroxysmal kinesigenic dyskinesia (PKD) and epilepsy are thought to have a shared genetic etiology. PRRT2 has been identified as a causative gene of both disorders. In this study, we aim to explore the potential novel causative gene in a PRRT2-negative family with three individuals diagnosed with PKD or genetic epilepsy with febrile seizures plus (GEFS+). METHODS: Clinical data were collected from all the affected and unaffected members of a PKD/GEFS+ family...
February 10, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29454194/diagnostic-and-treatment-services-for-patients-with-psychogenic-nonepileptic-seizures-pnes-a-survey-of-health-professionals-in-urban-china
#13
Xin Tong, Dongmei An, Markus Reuber, Qin Zhang, Dong Zhou
PURPOSE: This study is intended to provide an overview of diagnostic and treatment services for patients with psychogenic nonepileptic seizures (PNES) across China. METHODS: Using a questionnaire devised by the PNES Task Force of Neuropsychiatry Commission of the International League Against Epilepsy (ILAE), we conducted a survey among Chinese health professionals at the Sixth Advanced International Course: Clinical Epileptology. Descriptive analyses were performed...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29454186/use-of-pasteurised-human-donor-milk-across-neonatal-networks-in-england
#14
C Battersby, R Marciano Alves Mousinho, N Longford, N Modi
OBJECTIVES: To describe the use of pasteurised human donor milk (pHDM) in England and the influence of a human milk bank in the network. DESIGN: Prospective observational study SETTING: All 163 neonatal units (23 networks) in England 2012-2013. PATIENTS: Preterm infants born at <32 weeks gestational age (GA). MAIN OUTCOME MEASURES: Proportion of infants and care-days fed pHDM during the first 30 postnatal days by network METHODS: We extracted daily patient-level data from the National Neonatal Research Database (NNRD)...
February 14, 2018: Early Human Development
https://www.readbyqxmd.com/read/29454180/tryptophan-kynurenine-and-lipid-related-metabolites-as-blood-biomarkers-for-first-episode-drug-na%C3%A3-ve-patients-with-major-depressive-disorder-an-exploratory-pilot-case-control-study
#15
Nobuki Kuwano, Takahiro A Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenob Kanba
BACKGROUND: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. METHODS: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29454165/pituitary-gland-shrinkage-in-bipolar-disorder-the-role-of-gender
#16
Giuseppe Delvecchio, Gian Mario Mandolini, Cinzia Perlini, Marco Barillari, Veronica Marinelli, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: Hyperactivity of the Hypothalamic-Pituitary-Adrenal Axis (HPAA) has been consistently reported in mood disorders. However, only few studies investigated the Pituitary gland (PG) in Bipolar Disorder (BD) and the results are so far contrasting. Therefore, the aim of this study is to explore the integrity of the PG as well as the role of gender and the impact of clinical measurements on this structure in a sample of BD patients compared to healthy controls (HC). METHODS: 34 BD patients and 41 HC underwent a 1...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454164/self-reported-inhibition-predicts-history-of-suicide-attempts-in-bipolar-disorder-and-major-depression
#17
André Ponsoni, Laura Damiani Branco, Charles Cotrena, Flávio Milman Shansis, Rodrigo Grassi-Oliveira, Rochele Paz Fonseca
BACKGROUND: Studies have reliably identified an association between suicide attempts and executive functions such as decision making (DM) and inhibitory control (IC) in patients with mood disorders. As such, the present study aimed to investigate the association between inhibition, DM, impulsivity and the history of suicide attempts in individuals with bipolar (BD) or major depressive disorder (MDD), identifying which assessment instruments may be most strongly associated with suicide in clinical samples...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454163/exacerbations-in-adults-with-asthma-a-systematic-review-and-external-validation-of-prediction-models
#18
Rik Jb Loymans, Thomas Pa Debray, Persijn J Honkoop, Evelien H Termeer, Jiska B Snoeck-Stroband, Tjard Rj Schermer, Willem Jj Assendelft, Merel Timp, Kian Fan Chung, Ana R Sousa, Jaap K Sont, Peter J Sterk, Helen K Reddel, Gerben Ter Riet
BACKGROUND: Several prediction models assessing future risk of exacerbations in adult patients with asthma have been published. Applicability of these models is uncertain because their predictive performance has often not been assessed beyond the population in which they were derived. OBJECTIVE: This study aimed to identify and critically appraise prediction models for asthma exacerbations and validate them in two clinically distinct populations. METHODS: PubMed and EMBASE were searched to April 2017 for reports describing adult asthma populations in which multivariable models were constructed to predict exacerbations during any time frame...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29454150/assessment-of-cervical-stiffness-in-axial-rotation-among-chronic-neck-pain-patients-a-trial-in-the-framework-of-a-non-manipulative-osteopathic-management
#19
P-M Dugailly, A Coucke, W Salem, V Feipel
BACKGROUND: Cervical stiffness is a clinical feature commonly appraised during the functional examination of cervical spine. Measurements of cervical stiffness in axial rotation have not been reported for patients with neck pain. The purpose of this study was to investigate cervical spine stiffness in axial rotation among neck pain patients and asymptomatic subjects, and to analyze the impact of osteopathic management. METHODS: Thirty-five individuals (17 patients) were enrolled...
February 12, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29454147/factors-associated-with-malignancy-in-hysteroscopically-resected-endometrial-polyps-a-systematic-review-and-meta-analysis
#20
Lizandra M Paravidine Sasaki, Keitty R C Andrade, Ana Claudia Morais Godoy Figueiredo, Miriam da S Wanderley, Maurício G Pereira
The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible...
February 14, 2018: Journal of Minimally Invasive Gynecology
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