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JOURNAL ARTICLE
James H Dugdale, Tony Myers, Dajo Sanders, Matthew Andrew, Richard Clarke, Angus M Hunter
Training and assessment of agility is often prioritised by soccer coaches and practitioners aiming to develop multi-directional speed. Although the importance of agility is advocated throughout childhood and adolescence, limited data evidence agility performance at different stages of adolescence. The purpose of this study was to examine differences in multi-directional speed performance in youth soccer players spanning an entire soccer academy. A total of 86 male junior-elite soccer players volunteered to participate...
March 14, 2024: Journal of Sports Sciences
#2
JOURNAL ARTICLE
Michael S Haney, Róbert Pálovics, Christy Nicole Munson, Chris Long, Patrik K Johansson, Oscar Yip, Wentao Dong, Eshaan Rawat, Elizabeth West, Johannes C M Schlachetzki, Andy Tsai, Ian Hunter Guldner, Bhawika S Lamichhane, Amanda Smith, Nicholas Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, Geidy E Serrano, Thomas G Beach, Eric M Reiman, Christopher K Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Coray
Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1 . However, the relationship between lipid metabolism in glia and Alzheimer's disease pathology remains poorly understood. Through single-nucleus RNA sequencing of brain tissue in Alzheimer's disease, we have identified a microglial state defined by the expression of the lipid droplet-associated enzyme ACSL1 with ACSL1-positive microglia being most abundant in patients with Alzheimer's disease having the APOE4/4 genotype...
March 13, 2024: Nature
#3
JOURNAL ARTICLE
Chih-Wei Chen, Chi Su, Chang-Yu Huang, Xuan-Rong Huang, Xiaojing Cuili, Tung Chao, Chun-Hsiang Fan, Cheng-Wei Ting, Yi-Wei Tsai, Kai-Chien Yang, Ti-Yen Yeh, Sung-Tsang Hsieh, Yi-Ju Chen, Yuxi Feng, Tony Hunter, Zee-Fen Chang
NME3 is a member of the nucleoside diphosphate kinase (NDPK) family localized on the mitochondrial outer membrane (MOM). Here, we report a role of NME3 in hypoxia-induced mitophagy dependent on its active site phosphohistidine but not the NDPK function. Mice carrying a knock-in mutation in the Nme3 gene disrupting NME3 active site histidine phosphorylation are vulnerable to ischemia/reperfusion-induced infarction and develop abnormalities in cerebellar function. Our mechanistic analysis reveals that hypoxia-induced phosphatidic acid (PA) on mitochondria is essential for mitophagy and the interaction of DRP1 with NME3...
March 13, 2024: Nature Communications
#4
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#5
REVIEW
Tony Adebero, Humberto Omana, Lyndsay Somerville, Brent Lanting, Susan W Hunter
PURPOSE: To quantify the effectiveness of prehabilitation prior to total knee and hip arthroplasty (TKA/THA) for osteoarthritis on postoperative outcomes assessed by self-report and performance-based measures. METHODS: Embase, MEDLINE, CENTRAL, CINAHL and Scopus (inception-August 2022) were searched for randomized controlled trials. Self-report outcomes were function, health-related quality of life (HRQoL), and pain. Performance-based outcomes were strength, range of motion (ROM), balance, and functional mobility...
February 13, 2024: Disability and Rehabilitation
#6
JOURNAL ARTICLE
Kerith-Rae Dias, Rupendra Shrestha, Deborah Schofield, Carey-Anne Evans, Emily O'Heir, Ying Zhu, Futao Zhang, Krystle Standen, Ben Weisburd, Sarah L Stenton, Alba Sanchis-Juan, Harrison Brand, Michael E Talkowski, Alan Ma, Sondy Ghedia, Meredith Wilson, Sarah A Sandaradura, Janine Smith, Benjamin Kamien, Anne Turner, Madhura Bakshi, Lesley C Adès, David Mowat, Matthew Regan, George McGillivray, Ravi Savarirayan, Susan M White, Tiong Yang Tan, Zornitza Stark, Natasha J Brown, Luis A Pérez-Jurado, Emma Krzesinski, Matthew F Hunter, Lauren Akesson, Andrew Paul Fennell, Alison Yeung, Tiffany Boughtwood, Lisa Ewans, Jennifer Kerkhof, Christopher Lucas, Louise Carey, Hugh French, Melissa Rapadas, Igor Stevanovski, Ira W Deveson, Corrina Cliffe, George Elakis, Edwin P Kirk, Tracy Dudding-Byth, Janice Fletcher, Rebecca Walsh, Mark A Corbett, Thessa Kroes, Jozef Gecz, Cliff Meldrum, Simon Cliffe, Meg Wall, Sebastian Lunke, Kathryn North, David J Amor, Michael Field, Bekim Sadikovic, Michael F Buckley, Anne O'Donnell-Luria, Tony Roscioli
PURPOSE: Genome sequencing (GS)-specific diagnostic rates in prospective tightly ascertained exome sequencing (ES)-negative intellectual disability (ID) cohorts have not been reported extensively. METHODS: ES, GS, epigenetic signatures, and long-read sequencing diagnoses were assessed in 74 trios with at least moderate ID. RESULTS: The ES diagnostic yield was 42/74 (57%). GS diagnoses were made in 9/32 (28%) ES-unresolved families. Repeated ES with a contemporary pipeline on the GS-diagnosed families identified 8/9 SNVs/CNVs undetected in older ES, confirming a GS-unique diagnostic rate of 1/32 (3%)...
January 19, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#7
JOURNAL ARTICLE
Emily Peairs, Alexandra Hunter Aitchison, Ajay Premkumar, Nell Shea, Mark Fleming, Toni M McLaurin, Christian A Pean
No abstract text is available yet for this article.
March 6, 2024: Journal of Bone and Joint Surgery. American Volume
#8
JOURNAL ARTICLE
Michael H Haischer, Lauren E Opielinski, Lindsey M Mirkes, Toni D Uhrich, Rachel E Bollaert, Michael Danduran, Marie Hoeger Bement, Linda B Piacentine, Paula E Papanek, Sandra K Hunter
Reduced heart rate variability (HRV) and fatigue are common after COVID-19 infection and both are potentially influenced by physical activity (PA). We compared resting HRV, PA from accelerometers and questionnaires, and self-reported fatigue in 41 COVID-19 survivors (~8 months postinfection, 38 ± 17 years) with 41 matched controls. Differences in HRV were observed on acceleration capacity (p = 0.041), deceleration capacity (p = 0.032), high-frequency peak frequency (p = 0...
January 2024: Physiological Reports
#9
JOURNAL ARTICLE
Benjamin M Lewis, Chae Yun Cho, Hsuan-Lin Her, Orel Mizrahi, Tony Hunter, Gene W Yeo
Mitochondria-associated RNA-binding proteins (RBPs) have emerged as key contributors to mitochondrial biogenesis and homeostasis. With few examples known, we set out to identify RBPs that regulate nuclear-encoded mitochondrial mRNAs (NEMmRNAs). Our systematic analysis of RNA targets of 150 RBPs identified RBPs with a preference for binding NEMmRNAs, including LARP4, a La RBP family member. We show that LARP4's targets are particularly enriched in mRNAs that encode respiratory chain complex proteins (RCCPs) and mitochondrial ribosome proteins (MRPs) across multiple human cell lines...
December 20, 2023: RNA
#10
JOURNAL ARTICLE
Soorya Mukkadayil Sureshkumar, Hassan Qazi, Tony Goddard, Ahamad Hassan
No abstract text is available yet for this article.
December 30, 2023: Practical Neurology
#11
JOURNAL ARTICLE
Afnan S Al-Qurashi, Ashraf M Mashaly, Reem Alagmi, Mohamed S Al-Khalifa, Lamjed Mansour, Suliman Y Al-Omar, Mostafa R Sharaf, Abdulrahman S Aldawood, Hathal M Al-Dhafer, Tony Hunter, Masha'el Y Almutawa, Ashraf M Ahmed
The current study was carried out in the seaward coastal beach environment of Al-Jubail City, Saudi Arabia, to analyze the rabbit carcass decomposition process, the succession pattern of associated ants, and their potential utility in forensic investigation. Experiments were conducted over a 4-season course (from autumn 2018 to summer 2019). A total of 9 species belonging to the 2 subfamilies, Myrmicinae and Formicinae, were recorded. The myrmicine species were Crematogaster aegyptiaca Mayr, 1862; Messor ebeninus Santschi, 1927; Messor foreli Santschi, 1923; and Monomorium abeillei Andre, 1881...
December 16, 2023: Journal of Medical Entomology
#12
JOURNAL ARTICLE
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L Truitt, Corina E Antal, Annette R Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F M Pinto, Dylan C Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T Yu, Tony Hunter, Dannielle D Engle, Haiyong Han, Daniel D Von Hoff, Michael Downes, Ronald M Evans
Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key epigenetic factors facilitating the induction of pro-desmoplastic and pro-tumorigenic transcriptional programs in pancreatic stromal fibroblasts. Mechanistically, HDAC-mediated changes in chromatin architecture enable the activation of pro-desmoplastic programs directed by serum response factor (SRF) and forkhead box M1 (FOXM1)...
December 6, 2023: Nature Communications
#13
Sylvan C Baca, Ji-Heui Seo, Matthew P Davidsohn, Brad Fortunato, Karl Semaan, Shahabbedin Sotudian, Gitanjali Lakshminarayanan, Miklos Diossy, Xintao Qiu, Talal El Zarif, Hunter Savignano, John Canniff, Ikenna Madueke, Renee Maria Saliby, Ziwei Zhang, Rong Li, Yijia Jiang, Len Taing, Mark Awad, Cindy H Chau, James A DeCaprio, William D Figg, Tim F Greten, Aaron N Hata, F Stephen Hodi, Melissa E Hughes, Keith L Ligon, Nancy Lin, Kimmie Ng, Matthew G Oser, Catherine Meador, Heather A Parsons, Mark M Pomerantz, Arun Rajan, Jerome Ritz, Manisha Thakuria, Sara M Tolaney, Patrick Y Wen, Henry Long, Jacob E Berchuck, Zoltan Szallasi, Toni K Choueiri, Matthew L Freedman
No abstract text is available yet for this article.
March 2024: Nature Medicine
#14
JOURNAL ARTICLE
Aoife M L Hunter, Roger S Anderson, Tony Redmond, David F Garway-Heath, Pádraig J Mulholland
PURPOSE: To measure achromatic spatial, temporal, and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls under conditions of photopic gaze-contingent perimetry. METHODS: Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco's area (RA) at 2.5° and 5° eccentricities along the 0°, 90°, 180°, and 270° meridians...
November 1, 2023: Translational Vision Science & Technology
#15
Alexandra Melton, Lori A Rowe, Toni Penney, Clara Krzykwa, Kelly Goff, Sarah Scheuermann, Hunter J Melton, Kelsey Williams, Nadia Golden, Kristyn Moore Green, Brandon Smith, Kasi Russell-Lodrigue, Jason P Dufour, Lara A Doyle-Meyers, Faith Schiro, Pyone P Aye, Jeffery D Lifson, Brandon J Beddingfield, Robert V Blair, Rudolf P Bohm, Jay K Kolls, Jay Rappaport, James A Hoxie, Nicholas J Maness
Persistent and uncontrolled SARS-CoV-2 replication in immunocompromised individuals has been observed and may be a contributing source of novel viral variants that continue to drive the pandemic. Importantly, the effects of immunodeficiency associated with chronic HIV infection on COVID-19 disease and viral persistence have not been directly addressed in a controlled setting. Here we conducted a pilot study wherein two pigtail macaques (PTM) chronically infected with SIVmac239 were exposed to SARS-CoV-2 and monitored for six weeks for clinical disease, viral replication, and viral evolution, and compared to our previously published cohort of SIV-naïve PTM infected with SARS-CoV-2...
November 16, 2023: bioRxiv
#16
JOURNAL ARTICLE
Sylvan C Baca, Ji-Heui Seo, Matthew P Davidsohn, Brad Fortunato, Karl Semaan, Shahabbedin Sotudian, Gitanjali Lakshminarayanan, Miklos Diossy, Xintao Qiu, Talal El Zarif, Hunter Savignano, John Canniff, Ikenna Madueke, Renee Maria Saliby, Ziwei Zhang, Rong Li, Yijia Jiang, Len Taing, Mark Awad, Cindy H Chau, James A DeCaprio, William D Figg, Tim F Greten, Aaron N Hata, F Stephen Hodi, Melissa E Hughes, Keith L Ligon, Nancy Lin, Kimmie Ng, Matthew G Oser, Catherine Meador, Heather A Parsons, Mark M Pomerantz, Arun Rajan, Jerome Ritz, Manisha Thakuria, Sara M Tolaney, Patrick Y Wen, Henry Long, Jacob E Berchuck, Zoltan Szallasi, Toni K Choueiri, Matthew L Freedman
Although circulating tumor DNA (ctDNA) assays are increasingly used to inform clinical decisions in cancer care, they have limited ability to identify the transcriptional programs that govern cancer phenotypes and their dynamic changes during the course of disease. To address these limitations, we developed a method for comprehensive epigenomic profiling of cancer from 1 ml of patient plasma. Using an immunoprecipitation-based approach targeting histone modifications and DNA methylation, we measured 1,268 epigenomic profiles in plasma from 433 individuals with one of 15 cancers...
October 21, 2023: Nature Medicine
#17
JOURNAL ARTICLE
Kirsten M Williamson, Hemalatha Varadhan, Kylie Taylor, Kristy Crooks, Katie Brett, Charlee Law, Michelle Butler, Trent Butler, Emily Green, Joshua S Davis, Paul Wilson, Tambri Housen, Tony Merritt, David N Durrheim
Invasive Group A Streptococcal infection (iGAS) is an uncommon but serious infection with Streptococcus pyogenes in a normally sterile body site. Manifestations include bacteraemia, necrotising fasciitis and toxic shock syndrome with attendant serious morbidity and mortality. An increasing incidence of iGAS has been observed in some regions of Australia. iGAS became a nationally notifiable condition from 1 July 2021. To determine if regional incidence has increased, and to identify priority populations, we undertook a retrospective data analysis of Group A Streptococcal (GAS) bacteraemia cases in Hunter New England Local Health District (HNELHD), New South Wales, Australia, from 1 January 2008 to 31 December 2019, as identified by NSW Health Pathology, John Hunter Hospital...
August 24, 2023: Communicable Diseases Intelligence
#18
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L Truitt, Corina E Antal, Annette R Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F M Pinto, Dylan C Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T Yu, Tony Hunter, Dannielle D Engle, Haiyong Han, Daniel D Von Hoff, Michael Downes, Ronald M Evans
Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key epigenetic factors facilitating the induction of pro-desmoplastic and pro-tumorigenic transcriptional programs in pancreatic stromal fibroblasts. Mechanistically, HDAC-mediated changes in chromatin architecture enable the activation of pro-desmoplastic programs directed by serum response factor (SRF) and forkhead box M1 (FOXM1)...
September 14, 2023: bioRxiv
#19
JOURNAL ARTICLE
Dan Chen, Siva Karthik Varanasi, Toshiro Hara, Kacie Traina, Ming Sun, Bryan McDonald, Yagmur Farsakoglu, Josh Clanton, Shihao Xu, Lizmarie Garcia-Rivera, Thomas H Mann, Victor Du, H Kay Chung, Ziyan Xu, Victoria Tripple, Eduardo Casillas, Shixin Ma, Carolyn O'Connor, Qiyuan Yang, Ye Zheng, Tony Hunter, Greg Lemke, Susan M Kaech
The limited efficacy of immunotherapies against glioblastoma underscores the urgency of better understanding immunity in the central nervous system. We found that treatment with αCTLA-4, but not αPD-1, prolonged survival in a mouse model of mesenchymal-like glioblastoma. This effect was lost upon the depletion of CD4+ T cells but not CD8+ T cells. αCTLA-4 treatment increased frequencies of intratumoral IFNγ-producing CD4+ T cells, and IFNγ blockade negated the therapeutic impact of αCTLA-4...
September 12, 2023: Immunity
#20
Michael S Haney, Róbert Pálovics, Christy Nicole Munson, Chris Long, Patrik Johansson, Oscar Yip, Wentao Dong, Eshaan Rawat, Elizabeth West, Johannes Cm Schlachetzki, Andy Tsai, Ian Hunter Guldner, Bhawika S Lamichhane, Amanda Smith, Nicholas Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, Geidy E Serrano, Thomas G Beach, Eric M Reiman, Christopher K Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Coray
Several genetic risk factors for Alzheimer's Disease (AD) implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells. However, the relationship between lipid metabolism in glia and AD pathology remains poorly understood. Through single-nucleus RNA-sequencing of AD brain tissue, we have identified a microglial state defined by the expression of the lipid droplet (LD) associated enzyme ACSL1 with ACSL1-positive microglia most abundant in AD patients with the APOE4/4 genotype...
July 25, 2023: bioRxiv
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