keyword
MENU ▼
Read by QxMD icon Read
search

Tony Hunter

keyword
https://www.readbyqxmd.com/read/29773590/impact-of-ibrutinib-dose-intensity-on-patient-outcomes-in-previously-treated-waldenstr%C3%A3-m-macroglobulinemia
#1
Jorge J Castillo, Joshua N Gustine, Kirsten Meid, Toni E Dubeau, Lian Xu, Guang Yang, Zachary R Hunter, Ranjana Advani, Lia Palomba, Steven P Treon
No abstract text is available yet for this article.
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29668002/a-sharp-edge-based-acoustofluidic-chemical-signal-generator
#2
Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, Tony Jun Huang
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle...
April 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29661775/prospective-clinical-trial-of-ixazomib-dexamethasone-and-rituximab-as-primary-therapy-in-waldenstr%C3%A3-m-macroglobulinemia
#3
Jorge J Castillo, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Zachary R Hunter, Guang Yang, Lian Xu, Steven P Treon
INTRODUCTION: Proteasome inhibition is of proven efficacy in patients with Waldenström macroglobulinemia (WM). However, WM remains incurable with standard treatments. Novel agents, safe and effective, are needed. METHODS: We designed a prospective phase II study evaluating the combination of ixazomib, dexamethasone and rituximab (IDR) as primary therapy in symptomatic patients with WM. Protocol therapy consisted of oral ixazomib, 4 mg, with intravenous or oral dexamethasone, 20 mg, on days 1, 8 and 15 every 4 weeks for induction cycles 1 and 2, and in combination with intravenous rituximab, 375 mg/m2, on day 1, every 4 weeks for cycles 3 to 6...
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29599202/myd88-mutated-and-wild-type-waldenstr%C3%A3-ms-macroglobulinemia-characterization-of-chromosome-6q-gene-losses-and-their-mutual-exclusivity-with-mutations-in-cxcr4
#4
Maria Luisa Guerrera, Nickolas Tsakmaklis, Lian Xu, Guang Yang, Maria Demos, Amanda Kofides, Gloria G Chan, Robert J Manning, Xia Liu, Jiaji G Chen, Manit Munshi, Christopher J Patterson, Jorge J Castillo, Toni Dubeau, Joshua Gustine, Ruben D Carrasco, Luca Arcaini, Marzia Varettoni, Mario Cazzola, Steven P Treon, Zachary R Hunter
No abstract text is available yet for this article.
March 29, 2018: Haematologica
https://www.readbyqxmd.com/read/29562234/the-protein-histidine-phosphatase-lhpp-is-a-tumour-suppressor
#5
Sravanth K Hindupur, Marco Colombi, Stephen R Fuhs, Matthias S Matter, Yakir Guri, Kevin Adam, Marion Cornu, Salvatore Piscuoglio, Charlotte K Y Ng, Charles Betz, Dritan Liko, Luca Quagliata, Suzette Moes, Paul Jenoe, Luigi M Terracciano, Markus H Heim, Tony Hunter, Michael N Hall
Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized post-translational modification of proteins. Here we describe a role of histidine phosphorylation in tumorigenesis. Proteomic analysis of 12 tumours from an mTOR-driven hepatocellular carcinoma mouse model revealed that NME1 and NME2, the only known mammalian histidine kinases, were upregulated. Conversely, expression of the putative histidine phosphatase LHPP was downregulated specifically in the tumours. We demonstrate that LHPP is indeed a protein histidine phosphatase...
March 21, 2018: Nature
https://www.readbyqxmd.com/read/29507340/map4k3-mediates-amino-acid-dependent-regulation-of-autophagy-via-phosphorylation-of-tfeb
#6
Cynthia L Hsu, Elian X Lee, Kara L Gordon, Edwin A Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter, Albert R La Spada
Autophagy is the major cellular pathway by which macromolecules are degraded, and amino acid depletion powerfully activates autophagy. MAP4K3, or germinal-center kinase-like kinase, is required for robust cell growth in response to amino acids, but the basis for MAP4K3 regulation of cellular metabolic disposition remains unknown. Here we identify MAP4K3 as an amino acid-dependent regulator of autophagy through its phosphorylation of transcription factor EB (TFEB), a transcriptional activator of autophagy, and through amino acid starvation-dependent lysosomal localization of MAP4K3...
March 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29496671/btk-cys481ser-drives-ibrutinib-resistance-via-erk1-2-and-protects-btk-wild-type-myd88-mutated-cells-by-a-paracrine-mechanism
#7
Jiaji G Chen, Xia Liu, Manit Munshi, Lian Xu, Nicholas Tsakmaklis, Maria G Demos, Amanda Kofides, Maria Luisa Guerrera, Gloria G Chan, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, Patricia Severns, Jorge J Castillo, Zachary R Hunter, Jinhua Wang, Sara J Buhrlage, Nathanael S Gray, Steven P Treon, Guang Yang
Acquired ibrutinib resistance due to BTKCys481 mutations occurs in B-cell malignancies, including those with MYD88 mutations. BTKCys481 mutations are usually subclonal, and their relevance to clinical progression remains unclear. Moreover, the signaling pathways that promote ibrutinib resistance remain to be clarified. We therefore engineered BTKCys481Ser and BTKWT expressing MYD88-mutated Waldenström macroglobulinemia (WM) and activated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL) cells and observed reactivation of BTK-PLCγ2-ERK1/2 signaling in the presence of ibrutinib in only the former...
May 3, 2018: Blood
https://www.readbyqxmd.com/read/29468652/response-and-survival-for-primary-therapy-combination-regimens-and-maintenance-rituximab-in-waldenstr%C3%A3-m-macroglobulinaemia
#8
Jorge J Castillo, Joshua N Gustine, Kirsten Meid, Toni E Dubeau, Patricia Severns, Lian Xu, Guang Yang, Zachary R Hunter, Steven P Treon
Waldenström macroglobulinaemia (WM) is a rare and incurable lymphoma. Comparative studies evaluating the efficacy of primary therapy in symptomatic WM patients have not been performed. In this study, we compared response and survival outcomes in WM patients who received primary therapy with cyclophosphamide-dexamethasone-rituximab (CDR), bortezomib-dexamethasone-rituximab (BDR) and bendamustine-rituximab (Benda-R), as well as maintenance rituximab following primary therapy. Analyses were adjusted for relevant clinical factors associated with response and survival...
April 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29463470/metabolic-kinases-moonlighting-as-protein-kinases
#9
REVIEW
Zhimin Lu, Tony Hunter
Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and nucleoside diphosphate kinase 1 and 2 (NME1/2), that phosphorylate soluble metabolites can also function as protein kinases and phosphorylate a variety of protein substrates to regulate the Warburg effect, gene expression, cell cycle progression and proliferation, apoptosis, autophagy, exosome secretion, T cell activation, iron transport, ion channel opening, and many other fundamental cellular functions...
April 2018: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/29452582/to-what-extent-can-behaviour-change-techniques-be-identified-within-an-adaptable-implementation-package-for-primary-care-a-prospective-directed-content-analysis
#10
Liz Glidewell, Thomas A Willis, Duncan Petty, Rebecca Lawton, Rosemary R C McEachan, Emma Ingleson, Peter Heudtlass, Andrew Davies, Tony Jamieson, Cheryl Hunter, Suzanne Hartley, Kara Gray-Burrows, Susan Clamp, Paul Carder, Sarah Alderson, Amanda J Farrin, Robbie Foy
BACKGROUND: Interpreting evaluations of complex interventions can be difficult without sufficient description of key intervention content. We aimed to develop an implementation package for primary care which could be delivered using typically available resources and could be adapted to target determinants of behaviour for each of four quality indicators: diabetes control, blood pressure control, anticoagulation for atrial fibrillation and risky prescribing. We describe the development and prospective verification of behaviour change techniques (BCTs) embedded within the adaptable implementation packages...
February 17, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29417929/challenges-in-validating-candidate-therapeutic-targets-in-cancer
#11
Jeffrey Settleman, Charles L Sawyers, Tony Hunter
More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated with some of the research tools that are commonly used to validate candidate therapeutic targets in cancer research.
February 8, 2018: ELife
https://www.readbyqxmd.com/read/29358901/acoustofluidic-waveguides-for-localized-control-of-acoustic-wavefront-in-microfluidics
#12
Yusheng Bian, Feng Guo, Shujie Yang, Zhangming Mao, Hunter Bachman, Shi-Yang Tang, Liqiang Ren, Bin Zhang, Jianying Gong, Xiasheng Guo, Tony Jun Huang
The precise manipulation of acoustic fields in microfluidics is of critical importance for the realization of many biomedical applications. Despite the tremendous efforts devoted to the field of acoustofluidics during recent years, dexterous control, with an arbitrary and complex acoustic wavefront, in a prescribed, microscale region is still out of reach. Here, we introduce the concept of acoustofluidic waveguide, a three-dimensional compact configuration that is capable of locally guiding acoustic waves into a fluidic environment...
August 2017: Microfluidics and Nanofluidics
https://www.readbyqxmd.com/read/29302660/acoustofluidic-devices-controlled-by-cell-phones
#13
Hunter Bachman, Po-Hsun Huang, Shuaiguo Zhao, Shujie Yang, Peiran Zhang, Hai Fu, Tony Jun Huang
Acoustofluidic devices have continuously demonstrated their potential to impact medical diagnostics and lab-on-a-chip applications. To bring these technologies to real-world applications, they must be made more accessible to end users. Herein, we report on the effort to provide an easy-to-use and portable system for controlling sharp-edge-based acoustofluidic devices. With the use of a cell phone and a modified Bluetooth® speaker, on-demand and hands-free pumping and mixing are achieved. Additionally, a novel design for a sharp-edge-based acoustofluidic device is proposed that combines both pumping and mixing functions into a single device, thus removing the need for external equipment typically needed to accomplish these two tasks...
January 30, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29280186/ibrutinib-discontinuation-in-waldenstr%C3%A3-m-macroglobulinemia-etiologies-outcomes-and-igm-rebound
#14
Joshua N Gustine, Kirsten Meid, Toni Dubeau, Patricia Severns, Zachary R Hunter, Yang Guang, Lian Xu, Steven P Treon, Jorge J Castillo
Ibrutinib is the first approved therapy for symptomatic patients with Waldenström macroglobulinemia (WM). The reasons for discontinuing ibrutinib and subsequent outcomes have not been previously evaluated in WM patients. We therefore conducted a retrospective review of 189 WM patients seen at our institution who received treatment with ibrutinib, of whom 51 (27%) have discontinued therapy. Reasons for discontinuation include: disease progression (n = 27; 14%), toxicity (n = 15; 8%), nonresponse (n = 5; 3%), and other unrelated reasons (n = 4; 2%)...
August 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29219880/the-health-information-technology-competencies-tool-does-it-translate-for-nursing-informatics-in-the-united-states
#15
Carolyn Sipes, Kathleen Hunter, Dee McGonigle, Karen West, Taryn Hill, Toni Hebda
Information technology use in healthcare delivery mandates a prepared workforce. The initial Health Information Technology Competencies tool resulted from a 2-year transatlantic effort by experts from the US and European Union to identify approaches to develop skills and knowledge needed by healthcare workers. It was determined that competencies must be identified before strategies are established, resulting in a searchable database of more than 1000 competencies representing five domains, five skill levels, and more than 250 roles...
December 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29205807/post-operative-telephone-review-is-safe-and-effective-prospective-study-monash-outpatient-review-by-phone-trial
#16
Yi Ma, Gregory Jones, Yeng Kwang Tay, Toni Hunter, Dane Holden, Stephen Rodgers-Wilson, Paul Cashin, Pee Yau Tan, Daniel Croagh
INTRODUCTION: Studies have shown that post-operative telephone follow-up is satisfactory and effective. As high quality evidence is scant, we conducted a randomized controlled trial to compare it against outpatient clinic review for emergency laparoscopic appendicectomy or cholecystectomy. METHOD: Patients who received emergency laparoscopic appendicectomy or cholecystectomy were eligible for this study. Once recruited, they were randomly allocated to either clinic review or telephone follow-up on discharge...
December 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29181840/myd88-wild-type-waldenstrom-macroglobulinaemia-differential-diagnosis-risk-of-histological-transformation-and-overall-survival
#17
Steven P Treon, Joshua Gustine, Lian Xu, Robert J Manning, Nicholas Tsakmaklis, Maria Demos, Kirsten Meid, Maria L Guerrera, Manit Munshi, Gloria Chan, Jiaji Chen, Amanda Kofides, Christopher J Patterson, Guang Yang, Xia Liu, Patricia Severns, Toni Dubeau, Zachary R Hunter, Jorge J Castillo
MYD88 mutations are present in 95% of Waldenstrom Macroglobulinaemia (WM) patients, and support diagnostic discrimination from other IgM-secreting B-cell malignancies. Diagnostic discrimination can be difficult among suspected wild-type MYD88 (MYD88WT ) WM cases. We systematically reviewed the clinical, pathological and laboratory studies for 64 suspected MYD88WT WM patients. World Health Organization and WM consensus guidelines were used to establish clinicopathological diagnosis. Up to 30% of suspected MYD88WT WM cases had an alternative clinicopathological diagnosis, including IgM multiple myeloma...
February 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29118429/mesenchymal-stem-cells-internalize-mycobacterium-tuberculosis-through-scavenger-receptors-and-restrict-bacterial-growth-through-autophagy
#18
Arshad Khan, Lovepreet Mann, Ramesha Papanna, Mi-Ae Lyu, Christopher R Singh, Scott Olson, N Tony Eissa, Jeffrey Cirillo, Gobardhan Das, Robert L Hunter, Chinnaswamy Jagannath
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors with antibodies or siRNA knockdown decreased the uptake of Mtb. MSCs also expressed mannose receptor (MR) that was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not involved in the uptake of Mtb...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29104525/acoustic-separation-of-nanoparticles-in-continuous-flow
#19
Mengxi Wu, Zhangming Mao, Kejie Chen, Hunter Bachman, Yuchao Chen, Joseph Rufo, Liqiang Ren, Peng Li, Lin Wang, Tony Jun Huang
The separation of nanoscale particles based on their differences in size is an essential technique to the nanoscience and nanotechnology community. Here, nanoparticles are successfully separated in a continuous flow by using tilted-angle standing surface acoustic waves. The acoustic field deflects nanoparticles based on volume, and the fractionation of nanoparticles is optimized by tuning the cutoff parameters. The continuous separation of nanoparticlesis demonstrated with a ≈90% recovery rate. The acoustic nanoparticle separation method is versatile, non-invasive, and simple...
April 11, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29058706/histidine-kinases-and-the-missing-phosphoproteome-from-prokaryotes-to-eukaryotes
#20
Kevin Adam, Tony Hunter
Protein phosphorylation is the most common type of post-translational modification in eukaryotes. The phosphoproteome is defined as the complete set of experimentally detectable phosphorylation sites present in a cell's proteome under various conditions. However, we are still far from identifying all the phosphorylation sites in a cell mainly due to the lack of information about phosphorylation events involving residues other than Ser, Thr and Tyr. Four types of phosphate-protein linkage exist and these generate nine different phosphoresidues-pSer, pThr, pTyr, pHis, pLys, pArg, pAsp, pGlu and pCys...
February 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
keyword
keyword
30672
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"