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https://www.readbyqxmd.com/read/29302660/acoustofluidic-devices-controlled-by-cell-phones
#1
Hunter Bachman, Po-Hsun Huang, Shuaiguo Zhao, Shujie Yang, Peiran Zhang, Hai Fu, Tony Jun Huang
Acoustofluidic devices have continuously demonstrated their potential to impact medical diagnostics and lab-on-a-chip applications. To bring these technologies to real-world applications, they must be made more accessible to end users. Herein, we report on the effort to provide an easy-to-use and portable system for controlling sharp-edge-based acoustofluidic devices. With the use of a cell phone and a modified Bluetooth® speaker, on-demand and hands-free pumping and mixing are achieved. Additionally, a novel design for a sharp-edge-based acoustofluidic device is proposed that combines both pumping and mixing functions into a single device, thus removing the need for external equipment typically needed to accomplish these two tasks...
January 5, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29280186/ibrutinib-discontinuation-in-waldenstr%C3%A3-m-macroglobulinemia-etiologies-outcomes-and-igm-rebound
#2
Joshua N Gustine, Kirsten Meid, Toni Dubeau, Patricia Severns, Zachary R Hunter, Yang Guang, Lian Xu, Steven P Treon, Jorge J Castillo
Ibrutinib is the first approved therapy for symptomatic patients with Waldenström macroglobulinemia (WM). The reasons for discontinuing ibrutinib and subsequent outcomes have not been previously evaluated in WM patients. We therefore conducted a retrospective review of 189 WM patients seen at our institution who received treatment with ibrutinib, of whom 51 (27%) have discontinued therapy. Reasons for discontinuation include: disease progression (n=27; 14%), toxicity (n=15; 8%), non-response (n=5; 3%), and other unrelated reasons (n=4; 2%)...
December 27, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29219880/the-health-information-technology-competencies-tool-does-it-translate-for-nursing-informatics-in-the-united-states
#3
Carolyn Sipes, Kathleen Hunter, Dee McGonigle, Karen West, Taryn Hill, Toni Hebda
Information technology use in healthcare delivery mandates a prepared workforce. The initial Health Information Technology Competencies tool resulted from a 2-year transatlantic effort by experts from the US and European Union to identify approaches to develop skills and knowledge needed by healthcare workers. It was determined that competencies must be identified before strategies are established, resulting in a searchable database of more than 1000 competencies representing five domains, five skill levels, and more than 250 roles...
December 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29205807/post-operative-telephone-review-is-safe-and-effective-prospective-study-monash-outpatient-review-by-phone-trial
#4
Yi Ma, Gregory Jones, Yeng Kwang Tay, Toni Hunter, Dane Holden, Stephen Rodgers-Wilson, Paul Cashin, Pee Yau Tan, Daniel Croagh
INTRODUCTION: Studies have shown that post-operative telephone follow-up is satisfactory and effective. As high quality evidence is scant, we conducted a randomized controlled trial to compare it against outpatient clinic review for emergency laparoscopic appendicectomy or cholecystectomy. METHOD: Patients who received emergency laparoscopic appendicectomy or cholecystectomy were eligible for this study. Once recruited, they were randomly allocated to either clinic review or telephone follow-up on discharge...
December 5, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29181840/myd88-wild-type-waldenstrom-macroglobulinaemia-differential-diagnosis-risk-of-histological-transformation-and%C3%A2-overall-survival
#5
Steven P Treon, Joshua Gustine, Lian Xu, Robert J Manning, Nicholas Tsakmaklis, Maria Demos, Kirsten Meid, Maria L Guerrera, Manit Munshi, Gloria Chan, Jiaji Chen, Amanda Kofides, Christopher J Patterson, Guang Yang, Xia Liu, Patricia Severns, Toni Dubeau, Zachary R Hunter, Jorge J Castillo
MYD88 mutations are present in 95% of Waldenstrom Macroglobulinaemia (WM) patients, and support diagnostic discrimination from other IgM-secreting B-cell malignancies. Diagnostic discrimination can be difficult among suspected wild-type MYD88 (MYD88WT ) WM cases. We systematically reviewed the clinical, pathological and laboratory studies for 64 suspected MYD88WT WM patients. World Health Organization and WM consensus guidelines were used to establish clinicopathological diagnosis. Up to 30% of suspected MYD88WT WM cases had an alternative clinicopathological diagnosis, including IgM multiple myeloma...
November 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29118429/mesenchymal-stem-cells-internalize-mycobacterium-tuberculosis-through-scavenger-receptors-and-restrict-bacterial-growth-through-autophagy
#6
Arshad Khan, Lovepreet Mann, Ramesha Papanna, Mi-Ae Lyu, Christopher R Singh, Scott Olson, N Tony Eissa, Jeffrey Cirillo, Gobardhan Das, Robert L Hunter, Chinnaswamy Jagannath
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors with antibodies or siRNA knockdown decreased the uptake of Mtb. MSCs also expressed mannose receptor (MR) that was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not involved in the uptake of Mtb...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29104525/acoustic-separation-of-nanoparticles-in-continuous-flow
#7
Mengxi Wu, Zhangming Mao, Kejie Chen, Hunter Bachman, Yuchao Chen, Joseph Rufo, Liqiang Ren, Peng Li, Lin Wang, Tony Jun Huang
The separation of nanoscale particles based on their differences in size is an essential technique to the nanoscience and nanotechnology community. Here, nanoparticles are successfully separated in a continuous flow by using tilted-angle standing surface acoustic waves. The acoustic field deflects nanoparticles based on volume, and the fractionation of nanoparticles is optimized by tuning the cutoff parameters. The continuous separation of nanoparticlesis demonstrated with a ≈90% recovery rate. The acoustic nanoparticle separation method is versatile, non-invasive, and simple...
April 11, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29058706/histidine-kinases-and-the-missing-phosphoproteome-from-prokaryotes-to-eukaryotes
#8
Kevin Adam, Tony Hunter
Protein phosphorylation is the most common type of post-translational modification in eukaryotes. The phosphoproteome is defined as the complete set of experimentally detectable phosphorylation sites present in a cell's proteome under various conditions. However, we are still far from identifying all the phosphorylation sites in a cell mainly due to the lack of information about phosphorylation events involving residues other than Ser, Thr and Tyr. Four types of phosphate-protein linkage exist and these generate nine different phosphoresidues-pSer, pThr, pTyr, pHis, pLys, pArg, pAsp, pGlu and pCys...
October 23, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28981724/dna2-initiates-resection-at-clean-dna-double-strand-breaks
#9
Sharad C Paudyal, Shan Li, Hong Yan, Tony Hunter, Zhongsheng You
Nucleolytic resection of DNA double-strand breaks (DSBs) is essential for both checkpoint activation and homology-mediated repair; however, the precise mechanism of resection, especially the initiation step, remains incompletely understood. Resection of blocked ends with protein or chemical adducts is believed to be initiated by the MRN complex in conjunction with CtIP through internal cleavage of the 5' strand DNA. However, it is not clear whether resection of clean DSBs with free ends is also initiated by the same mechanism...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28887939/the-radiation-environment-on-the-surface-of-mars-summary-of-model-calculations-and-comparison-to-rad-data
#10
Daniel Matthiä, Donald M Hassler, Wouter de Wet, Bent Ehresmann, Ana Firan, John Flores-McLaughlin, Jingnan Guo, Lawrence H Heilbronn, Kerry Lee, Hunter Ratliff, Ryan R Rios, Tony C Slaba, Michael Smith, Nicholas N Stoffle, Lawrence W Townsend, Thomas Berger, Günther Reitz, Robert F Wimmer-Schweingruber, Cary Zeitlin
The radiation environment at the Martian surface is, apart from occasional solar energetic particle events, dominated by galactic cosmic radiation, secondary particles produced in their interaction with the Martian atmosphere and albedo particles from the Martian regolith. The highly energetic primary cosmic radiation consists mainly of fully ionized nuclei creating a complex radiation field at the Martian surface. This complex field, its formation and its potential health risk posed to astronauts on future manned missions to Mars can only be fully understood using a combination of measurements and model calculations...
August 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28798539/acoustofluidic-bacteria-separation
#11
Sixing Li, Fen Ma, Hunter Bachman, Craig E Cameron, Xiangqun Zeng, Tony Jun Huang
Bacterial separation from human blood samples can help with the identification of pathogenic bacteria for sepsis diagnosis. In this work, we report an acoustofluidic device for label-free bacterial separation from human blood samples. In particular, we exploit the acoustic radiation force generated from a tilted-angle standing surface acoustic wave (taSSAW) field to separate E. coli from human blood cells based on their size difference. Flow cytometry analysis of the E. coli separated from red blood cells (RBCs) shows a purity of more than 96%...
January 1, 2017: Journal of Micromechanics and Microengineering: Structures, Devices, and Systems
https://www.readbyqxmd.com/read/28646879/discovery-of-a-single-male-aedes-aegypti-l-in-merseyside-england
#12
Thom Dallimore, Tony Hunter, Jolyon M Medlock, Alexander G C Vaux, Ralph E Harbach, Clare Strode
BACKGROUND: The mosquito Aedes aegypti (L.) is found in tropical and sub-tropical regions where it is the major vector of dengue fever, yellow fever, chikungunya and more recently Zika virus. Given its importance as a vector of arboviruses and its propensity to be transported to new regions, the European Centre for Disease Prevention and Control (ECDC) has placed Ae. aegypti on a list of potentially invasive mosquito species. It was previously reported in the United Kingdom (UK) in 1865 and 1919 but did not establish on either occasion...
June 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28630309/qnas-with-tony-hunter-and-james-allison
#13
Prashant Nair
No abstract text is available yet for this article.
June 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28604697/site-specific-incorporation-of-phosphotyrosine-using-an-expanded-genetic-code
#14
Christian Hoppmann, Allison Wong, Bing Yang, Shuwei Li, Tony Hunter, Kevan M Shokat, Lei Wang
Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation. Here we report an efficient method to generate pure, active phosphotyrosine-containing proteins by genetically encoding a stable phosphotyrosine analog that is convertible to native phosphotyrosine. We demonstrate its general compatibility with proteins of various sizes, phosphotyrosine sites and functions, and reveal a possible role of tyrosine phosphorylation in negative regulation of ubiquitination...
August 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28485115/serum-igm-level-as-predictor-of-symptomatic-hyperviscosity-in-patients-with-waldenstr%C3%A3-m-macroglobulinaemia
#15
Joshua N Gustine, Kirsten Meid, Toni Dubeau, Zachary R Hunter, Lian Xu, Guang Yang, Irene M Ghobrial, Steven P Treon, Jorge J Castillo
Symptomatic hyperviscosity is a common clinical manifestation in patients with Waldenström macroglobulinaemia (WM) and high serum IgM levels. Prompt intervention is required to prevent catastrophic events, such as retinal or central nervous system bleeding. Identifying patients at high risk of symptomatic hyperviscosity might support the decision to treat asymptomatic patients before irreversible damage occurs. We carried out a large retrospective study in 825 newly diagnosed WM patients, of who 113 (14%) developed symptomatic hyperviscosity...
June 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28461335/mechanism-of-ubiquitin-chain-synthesis-employed-by-a-hect-domain-ubiquitin-ligase
#16
Michael E French, Julian L Klosowiak, Aaron Aslanian, Steven I Reed, John R Yates, Tony Hunter
Homologous to E6AP C-terminal (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester intermediate. The mechanisms by which these E3s assemble polyubiquitin chains on their substrates remain poorly defined. We report here that the Nedd4 family HECT E3, WWP1, assembles substrate-linked Ub chains containing Lys-63, Lys-48, and Lys-11 linkages (Lys-63 > Lys-48 > Lys-11). Our results demonstrate that WWP1 catalyzes the formation of Ub chains through a sequential addition mechanism, in which Ub monomers are transferred in a successive fashion to the substrate, and that ubiquitination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HECT domain...
June 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28432725/synthesis-and-biological-potency-of-anilino-triazine-insecticides
#17
Timothy C Johnson, Annette V Brown, Kristy K Bryan, Katherine K Guenthenspberger, Ricky Hunter, Timothy P Martin, Noormohamed Niyaz, Gene F Tisdell, Tony Trullinger
BACKGROUND: An insecticide screening effort identified N-(4-bromophenyl)-4,6-bis(2,2,2-trifluoroethoxy)-1,3,5-triazine-2-amine as having weak potency against two lepidopteran species, Helicoverpa zea and Spodoptera exigua. A structure-activity relationship study about the trifluoroethoxy substituents and the aniline of this compound was carried out in an effort to improve insecticidal potency. RESULTS: Initially, a series of analogs bearing various substituents on the aniline were prepared, and the insecticidal potency was evaluated against H...
April 22, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28235842/acquired-mutations-associated-with-ibrutinib-resistance-in-waldenstr%C3%A3-m-macroglobulinemia
#18
Lian Xu, Nicholas Tsakmaklis, Guang Yang, Jiaji G Chen, Xia Liu, Maria Demos, Amanda Kofides, Christopher J Patterson, Kirsten Meid, Joshua Gustine, Toni Dubeau, M Lia Palomba, Ranjana Advani, Jorge J Castillo, Richard R Furman, Zachary R Hunter, Steven P Treon
Ibrutinib produces high response rates and durable remissions in Waldenström macroglobulinemia (WM) that are impacted by MYD88 and CXCR4(WHIM) mutations. Disease progression can develop on ibrutinib, although the molecular basis remains to be clarified. We sequenced sorted CD19(+) lymphoplasmacytic cells from 6 WM patients who progressed after achieving major responses on ibrutinib using Sanger, TA cloning and sequencing, and highly sensitive and allele-specific polymerase chain reaction (AS-PCR) assays that we developed for Bruton tyrosine kinase (BTK) mutations...
May 4, 2017: Blood
https://www.readbyqxmd.com/read/28129587/phisphorylation-the-emergence-of-histidine-phosphorylation-as-a-reversible-regulatory-modification
#19
REVIEW
Stephen Rush Fuhs, Tony Hunter
Histidine phosphorylation is crucial for prokaryotic signal transduction and as an intermediate for several metabolic enzymes, yet its role in mammalian cells remains largely uncharted. This is primarily caused by difficulties in studying histidine phosphorylation because of the relative instability of phosphohistidine (pHis) and lack of specific antibodies and methods to preserve and detect it. The recent synthesis of stable pHis analogs has enabled development of pHis-specific antibodies and their use has started to shed light onto this important, yet enigmatic posttranslational modification...
April 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28068078/enriching-nanoparticles-via-acoustofluidics
#20
Zhangming Mao, Peng Li, Mengxi Wu, Hunter Bachman, Nicolas Mesyngier, Xiasheng Guo, Sheng Liu, Francesco Costanzo, Tony Jun Huang
Focusing and enriching submicrometer and nanometer scale objects is of great importance for many applications in biology, chemistry, engineering, and medicine. Here, we present an acoustofluidic chip that can generate single vortex acoustic streaming inside a glass capillary through using low-power acoustic waves (only 5 V is required). The single vortex acoustic streaming that is generated, in conjunction with the acoustic radiation force, is able to enrich submicrometer- and nanometer-sized particles in a small volume...
January 24, 2017: ACS Nano
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