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https://www.readbyqxmd.com/read/28431455/uhplc-q-tof-ms-ms-based-screening-and-characterization-of-metabolites-of-cnidilin-in-human-liver-microsomes
#1
Lin Yuan, Yuqian Zhang, Man Liao, Yanyan Liu, Changchen Wan, Lantong Zhang
Cnidilin is an active natural furocoumarin ingredient originating from well-known traditional Chinese medicine Radix Angelicae dahuricae. In the present study, an efficient approach was developed for the screening and identification of cnidilin metabolites using ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. In this approach, an on-line data acquisition method multiple mass defect filter (MMDF) combined with dynamic background subtraction was developed to trace all probable metabolites...
April 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28431407/prognositic-value-of-cd73-adenosinergic-pathway-in-solid-tumor-a-meta-analysis-and-systematic-review
#2
Rong Wang, Yingying Zhang, Xia Lin, Yalin Gao, Ying Zhu
CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, plays multiple roles in tumor processes. Previous studies have presented a potential value of CD73 served as a detectable biomarker for prognosis of several solid tumors, but the results were more controversially. A comprehensive meta-analysis was conducted to precisely evaluate the prognostic role of CD73 in solid tumors. The included studies were searched in PubMed, Web of Science and EBSCO from Jan 1990 to Jan 2016...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28431392/characterization-of-aurora-a-and-its-impact-on-the-effect-of-cisplatin-based-chemotherapy-in-patients-with-non-small-cell-lung-cancer
#3
Peng Kuang, Zuhua Chen, JiaYuan Wang, Zhentao Liu, Jingyuan Wang, Jing Gao, Lin Shen
BACKGROUND AND OBJECTIVE: Aurora A, as a member of serine/threonine kinase family and a common characteristic of epithelial cancers, plays a critical role in cell mitosis. However, the clinical significance of Aurora A in non-small cell lung cancer (NSCLC) remains undetermined. METHODS: The expression of Aurora A in NSCLC and paired normal adjacent lung tissues was determined by immunohistochemistry, Western blot, and reverse transcriptase polymerase chain reaction...
April 18, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28431338/the-design-and-fabrication-of-beta-sensor-system-for-in-situ-diffusion-tests-in-mudstone-in-france
#4
Zhenhua Lin, Olivier Tillement, Marie-Genevieve Blanchin, Vivek Jindal, Agnès Vinsot, Romain V H Dagnelie, Virginie Blin, Yanick Lettry, Benoit Hautefeuille
Long term in situ diffusion experiments in the Callovian-Oxfordian mudstone (France) are designed in the context of nuclear waste management. β-emitters HTO and (36)Cl radiotracers are representative of neutral and anionic species in these experiments. Studies have been carried out to design an in situ beta monitoring system in order to quantify tracer migration in the rock pore water over time. The development, design and calibration of β-emitter radiation sensors were performed. An optimised geometry was calculated for the detection chamber of (36)Cl in solution (Ø×L=30×2mm(2)) via Monte-Carlo N-Particle transport simulation tools...
April 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28431050/role-of-adenosine-guided-pulmonary-vein-isolation-in-patients-undergoing-catheter-ablation-for-atrial-fibrillation-a-meta-analysis
#5
Yi-He Chen, Hui Lin, Cheng-Long Xie, Jian-Wen Hou, Yi-Gang Li
Aims: Adenosine had been reported to unmask dormant conduction and thus identify pulmonary vein at risk of reconnection. However, the role of adjunctive adenosine infusion after pulmonary vein isolation (PVI) on long-term arrhythmia-free survival was still contentious. The purpose of the present meta-analysis was to assess the association of adenosine testing with long-term ablation success in patients with atrial fibrillation (AF) (i.e. freedom from AF recurrence). Methods and Results: We systematically searched the electronic databases and finally included 10 studies, with 1771 patients undergoing adenosine-guided PVI and 1787 patients undergoing conventional PVI...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28431029/the-chinese-version-of-the-brief-assessment-of-cognition-in-schizophrenia-data-of-a-large-scale-mandarin-speaking-population
#6
Liang-Jen Wang, Yu-Chi Huang, Chi-Fa Hung, Chih-Ken Chen, Yi-Chih Chen, Pei-Yi Lee, Si-Ming Wang, Ming-Hsiung Liu, Chia-Ju Lin, Su-Ting Hsu
Objective: The Brief Assessment of Cognition in Schizophrenia (BACS) is a cognitive assessment tool used to measure the broad aspects of cognition that are most frequently impaired in patients with schizophrenia. This study aims to develop the normative data of the Chinese version of the BACS among the Mandarin-speaking population. Method: This cross-sectional study included 382 healthy participants (age range: 19-79 years; mean age: 48.0 ± 16.7 years, 47.6% men) in Taiwan, who were evaluated with the BACS...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28431022/cpp1-phosphatase-mediated-signaling-crosstalk-between-hog1-and-cek1-mitogen-activated-protein-kinases-is-involved-in-the-phenotypic-transition-in-candida-albicans
#7
Fu-Sheng Deng, Ching-Hsuan Lin
Cellular signaling pathways involved in cell growth and differentiation mediated by mitogen-activated protein kinase (MAPK) cascades have been well characterized in fungi. However, the mechanisms of signaling crosstalk between MAPKs to ensure signaling specificity are largely unknown. Previous work showed that activation of the Candida albicans Cek1 MAPK pathway resulted in opaque cell formation and filamentation, which mirrored the phenotypes to hog1Δ. Additionally, deleting the HOG1 gene stimulated Cek1p...
April 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28431012/replication-and-repair-of-a-reduced-2%C3%AE-deoxyguanosine-abasic-site-interstrand-cross-link-in-human-cells
#8
Nathan E Price, Lin Li, Kent S Gates, Yinsheng Wang
Apurinic/apyrimidinic (AP) sites, or abasic sites, which are a common type of endogenous DNA damage, can forge interstrand DNA-DNA cross-links via reaction with the exocyclic amino group on a nearby 2΄-deoxyguanosine or 2΄-deoxyadenosine in the opposite strand. Here, we utilized a shuttle vector method to examine the efficiency and fidelity with which a reduced dG-AP cross-link-containing plasmid was replicated in cultured human cells. Our results showed that the cross-link constituted strong impediments to DNA replication in HEK293T cells, with the bypass efficiencies for the dG- and AP-containing strands being 40% and 20%, respectively...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28430938/characterization-of-yjjj-toxin-of-escherichia-coli
#9
Yuki Maeda, Chun-Yi Lin, Yojiro Ishida, Masayori Inouye, Yoshihiro Yamaguchi, Sangita Phadtare
Reminiscent of eukaryotic apoptotic programmed cell death, bacteria also contain a large number of suicide genes, which are in general co-expressed with their cognate antitoxic genes. These systems called the toxin-antitoxin (TA) systems are associated with cellular dormancy, and play major roles in biofilm formation and persistent multi-drug resistance of many human pathogens. In recent years, the study on TA system toxins has become a hot topic due to the health implications of these toxins by virtue of their role in bacterial pathogenicity...
April 19, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28430851/accuracy-of-offspring-reported-parental-hip-fractures-a-novel-population-based-parent-offspring-record-linkage-study
#10
Lisa M Lix, William D Leslie, Shuman Yang, Lin Yan, Randy Walld, Suzanne N Morin, Sumit R Majumdar, Leslie L Roos
The objective of this study was to test the validity of offspring-reported parental hip fracture in a unique bone mineral density (BMD) registry linked to administrative databases spanning 4 decades. Population-based data were from Manitoba, Canada, and included hospital abstracts, health insurance registrations, and the provincewide BMD registry. The cohort included individuals aged ≥40 years with BMD tests and self-reports of parental hip fracture between 2006 and 2014. Population registry data for 1966-2014 were used to link offspring with their parents, and hospital records were used to ascertain parental fractures...
April 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28430823/modulation-the-alternative-splicing-of-gla-ivs4-919g-a-in-fabry-disease
#11
Wen-Hsin Chang, Dau-Ming Niu, Chi-Yu Lu, Shyr-Yi Lin, Ta-Chih Liu, Jan-Gowth Chang
While a base substitution in intron 4 of GLA (IVS4+919G>A) that causes aberrant alternative splicing resulting in Fabry disease has been reported, its molecular mechanism remains unclear. Here we reported that upon IVS4+919G>A transversion, H3K36me3 was enriched across the alternatively spliced region. PSIP1, an adapter of H3K36me3, together with Hsp70 and NONO were recruited and formed a complex with SF2/ASF and SRp20, which further promoted GLA splicing. Amiloride, a splicing regulator in cancer cells, could reverse aberrant histone modification patterns and disrupt the association of splicing complex with GLA...
2017: PloS One
https://www.readbyqxmd.com/read/28430668/a-turn-on-fluorescent-probe-for-endogenous-formaldehyde-in-the-endoplasmic-reticulum-of-living-cells
#12
Yonghe Tang, Yanyan Ma, An Xu, Gaoping Xu, Weiying Lin
As the simplest aldehyde compounds, formaldehyde (FA) is implicated in nervous system diseases and cancer. Endoplasmic reticulum is an organelle that plays important functions in living cells. Accordingly, the development of efficient methods for FA detection in the endoplasmic reticulum (ER) is of great biomedical importance. In this work, we developed the first ER-targeted fluorescent FA probe Na-FA-ER. The detection is based on the condensation reaction of the hydrazine group and FA to suppress the photo-induced electron transfer (PET) pathway, resulting in a fluorescence increase...
April 21, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28430629/vascular-endothelial-growth-factor-a-polymorphisms-are-associated-with-increased-risk-of-coronary-heart-disease-a-meta-analysis
#13
Yafeng Wang, Qiuyu Huang, Jianchao Liu, Yanan Wang, Gongfeng Zheng, Ling Lin, Hui Yu, Weifeng Tang, Ziyang Huang
Coronary heart disease (CHD) is a common complex disease resulting from the interaction of multiple environmental and genetic factors. To assess the potential relationship of vascular endothelial growth factor (VEGFA) rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms with CHD risk, a comprehensive meta-analysis was conducted. A systematic search of EMBASE and PubMed online database for publications on VEGFA polymorphisms and risk of CHD was carried out. Crude Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated to determine the association...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430605/prognostic-significance-of-neutrophil-to-lymphocyte-ratio-in-patients-with-malignant-pleural-mesothelioma-a-meta-analysis
#14
Nan Chen, Shuai Liu, Lin Huang, Wanling Li, Wenhao Yang, Tianxin Cong, Lin Ding, Meng Qiu
Systemic inflammation responses can be reflected by peripheral blood count and combine index like the neutrophil-to-lymphocyte (NLR). The NLR has been reported to be a poor prognostic indicator in cancer recently. However, the prognostic effect of the NLR in patients with malignant pleural mesothelioma (MPM) still unclear yet. We conducted this meta-analysis aiming to evaluate the pooled value of NLR in prognosis as well as clinical characteristics in malignant pleural mesothelioma. A total of 11 studies with 1533 patients were included in this meta-analysis, in which 10 studies investigated the prognosis role of NLR using hazard ratio (HR) and 95% confidence intervals (95% CI)...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430598/prognostic-significance-of-satb1-in-gastrointestinal-cancer-a-meta-analysis-and-literature-review
#15
REVIEW
Sheng Zhang, Yi Xin Tong, Xiang Shang Xu, Hui Lin, Teng Fei Chao
BACKGROUND: The special AT-rich sequence-binding proteins 1 (SATB1) is a major regulator involved in cell differentiation. It has been shown that SATB1 acts as an oncogenic regulator. The clinical and prognostic significance of SATB1 in gastrointestinal cancer remains controversial. The purpose of this study is to conduct a systematic review and meta-analysis to elucidate the impact of SATB1 in gastrointestinal cancer. RESULTS: A total of 3174 gastrointestinal cancer patients from 15 studies were included...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430561/association-of-gii-p16-gii-2-recombinant-norovirus-strain-with-increased-norovirus-outbreaks-guangdong-china-2016
#16
Jing Lu, Ling Fang, Limei Sun, Hanri Zeng, Yanling Li, Huanying Zheng, Siwei Wu, Feng Yang, Tie Song, Jinyan Lin, Changwen Ke, Yonghui Zhang, Jan Vinjé, Hui Li
An unusual prevalence of recombinant GII.2 noroviruses (GII.P16-GII.2) in Guangdong, China, at the end of 2016 caused a sharp increase in outbreaks of acute gastroenteritis. This event was another non-GII.4 epidemic that emerged after the GII.17 viruses in 2014 and 2015 and warrants global surveillance.
July 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28430415/omnidirectional-harvesting-of-weak-light-using-a-graphene-quantum-dot-modified-organic-silicon-hybrid-device
#17
Meng-Lin Tsai, Dung-Sheng Tsai, Libin Tang, Lih-Juann Chen, Shu Ping Lau, Jr-Hau He
Despite great improvements in traditional inorganic photodetectors and photovoltaics, more progress is needed in the detection/collection of light at low-level conditions. Traditional photodetectors tend to suffer from high noise when operated at room temperature; therefore these devices require additional cooling systems to detect weak or dim light. Conventional solar cells also face the challenge of poor light-harvesting capabilities in hazy or cloudy weather. The real world features such varying levels of light, which makes it important to develop strategies that allow optical devices to function when conditions are less than optimal...
April 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28430229/light-scattering-from-normal-and-cervical-cancer-cells
#18
Xiaogang Lin, Nan Wan, Lingdong Weng, Yong Zhou
The light scattering characteristic plays a very important role in optic imaging and diagnostic applications. For optical detection of the cell, cell scattering characteristics have an extremely vital role. In this paper, we use the finite-difference time-domain (FDTD) algorithm to simulate the propagation and scattering of light in biological cells. The two-dimensional scattering cell models were set up based on the FDTD algorithm. The cell models of normal cells and cancerous cells were established, and the shapes of organelles, such as mitochondria, were elliptical...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28430226/stable-nanosecond-passively-q-switched-all-fiber-erbium-doped-laser-with-a-45%C3%A2-tilted-fiber-grating
#19
Tianxing Wang, Zhijun Yan, Chengbo Mou, Kaiming Zhou, Lin Zhang
Nanosecond passive Q-switching generation from an all-fiber erbium-doped laser with a UV inscribed 45° tilted fiber grating (TFG) is systematically demonstrated. The 45° TFG is employed as a polarizer together with two polarization controllers (PCs) to realize nonlinear polarization rotation (NPR). Because of the NPR effect, stable Q-switched pulses with an average output power of 17.5 mW, a single pulse energy of 72.7 nJ, a repetition rate of 241 kHz, a pulse width of 466 ns, and a signal to noise ratio (SNR) of 58...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28430211/compact-high-power-high-beam-quality-quasi-cw-microsecond-five-pass-zigzag-slab-1319%C3%A2-%C3%A2-nm-amplifier
#20
Chuan Guo, Junwei Zuo, Qi Bian, Chang Xu, Qinshuang Zong, Yong Bo, Yu Shen, Nan Zong, Hongwei Gao, Yanyong Lin, Lei Yuan, Yang Liu, Dafu Cui, Qinjun Peng, Zuyan Xu
We demonstrate a compact, high-power, quasi-continuous-wave (QCW) end-pumped 1319 nm Nd:YAG slab amplifier laser with good beam quality. The laser is based on a QCW pulse Nd:YAG master oscillator and Nd:YAG slab amplifier with multi-pass zigzag architecture. The amplifier operates at a pulse repetition frequency of 500 Hz and pulse width of ∼105  μs, delivering a maximum output power of 51.5 W under absorbed pump power of 217.8 W and corresponding to an extraction efficiency of 14.2%. The beam quality factor is measured to be Mx2=1...
April 20, 2017: Applied Optics
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