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https://www.readbyqxmd.com/read/28551805/mitochondria-damage-and-kidney-disease
#1
Pu Duann, Pei-Hui Lin
The kidney is a vital organ that demands an extraordinary amount of energy to actively maintain the body's metabolism, plasma hemodynamics, electrolytes and water homeostasis, nutrients reabsorption, and hormone secretion. Kidney is only second to the heart in mitochondrial count and oxygen consumption. As such, the health and status of the energy power house, the mitochondria, is pivotal to the health and proper function of the kidney. Mitochondria are heterogeneous and highly dynamic organelles and their functions are subject to complex regulations through modulation of its biogenesis, bioenergetics, dynamics and clearance within cell...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551329/myeloproliferative-neoplasms-with-t-8-22-p11-2-q11-2-bcr-fgfr1-a-meta-analysis-of-20-cases-shows-cytogenetic-progression-with-b-lymphoid-blast-phase
#2
Ximena Montenegro-Garreaud, Roberto N Miranda, Alexandra Reynolds, Guilin Tang, Sa A Wang, Mariko Yabe, Wei Wang, Lianghua Fang, Carlos E Bueso-Ramos, Pei Lin, L Jeffrey Medeiros, Xinyan Lu
Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to lymphoblastic leukemia/lymphoma or acute myeloid leukemia. The most common partner of the FGFR1 is ZMYM2 and patients with the ZMYM2-FGFR1 fusion often present with MPN and T-lymphoblastic lymphoma. There are 14 other partners that can fuse with the FGFR1 and of interest is the BCR-FGFR1 fusion that results from t(8;22)(p11.2;q11.2). Patients with t(8;22) often show leukocytosis and present with an MPN resembling chronic myeloid leukemia (CML) or very rarely, with B lymphoblastic leukemia (B-ALL)...
May 24, 2017: Human Pathology
https://www.readbyqxmd.com/read/28551257/a-study-to-evaluate-the-potential-of-an-in-silico-approach-for-predicting-dipeptidyl-peptidase-iv-inhibitory-activity-in-vitro-of-protein-hydrolysates
#3
Tzu-Yuan Wang, Cheng-Hong Hsieh, Chuan-Chuan Hung, Chia-Ling Jao, Pei-Yi Lin, You-Liang Hsieh, Kuo-Chiang Hsu
A total of 294 edible protein sequences and 5 commercial proteases listed in the BIOPEP database were analyzed in silico. The frequency (A), a parameter in silico described previously, was examined further to calculating the ratio of truncated peptides with Xaa-proline and/or Xaa-alanine to all peptide fragments in a protein hydrolyzed with a protease, using the BIOPEP database. Then the in vitro DPP-IV inhibitory activity was determined using the same 15 protein and protease combinations to evaluate their relationship...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551205/remediation-of-water-contaminated-with-diesel-oil-using-a-coupled-process-biological-degradation-followed-by-heterogeneous-fenton-like-oxidation
#4
Yuan Chen, Jiajiang Lin, Zuliang Chen
The treatment of a synthetically prepared wastewater containing diesel oil has been investigated using combined treatment schemes based on the biological treatment followed by an advanced oxidation process. 78% of diesel oil was degraded by Acinetobacter venetianus in 96 h, while the removal efficiency of chemical oxygen demand (COD) in the aqueous phase was only 56.8%, indicating that degraded metabolites existed in solution. To solve this problem, a Fenton-like system consisting of nanoscale zero-valent iron (nZVI) and hydrogen peroxide was used for further oxidation of the metabolites after biodegradation...
May 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/28551159/sensitive-determination-of-se-iv-and-tse-in-rice-and-water-samples-using-l-cysteine-modified-carbon-paste-electrode-based-electrolytic-hydride-generation-and-atomic-fluorescence-spectrometry-analysis
#5
Lin Liu, Xin-An Yang, Xiao-Ping Lu, Wang-Bing Zhang
This work illustrates an accurate method for determination of Se by electrolytic hydride generation technique based on a novel carbon paste electrode for sample introduction combined with atomic fluorescence spectral analysis. The studies show that Se(IV) can be converted efficiently to SeH2 on an L-cysteine modified carbon paste electrode (CMCPE), which has never been reported before. Significantly, generation from Se(IV) implies that the use of carbon paste electrode-based electron-induced hydride generation system to achieve efficiency is almost 90% to that obtained by chemical hydride generation, and the response obtained from CMCPE is 2 and 3 times of that from the Pb and graphite electrode, respectively...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551129/quantitative-determination-of-vegf165-in-cell-culture-medium-by-aptamer-sandwich-based-chemiluminescence-assay
#6
Siwen Shan, Ziyi He, Sifeng Mao, Mingsha Jie, Linglu Yi, Jin-Ming Lin
In this work, we have developed a sensitive and selective chemiluminescence (CL) assay for vascular endothelial growth factor (VEGF165) quantitative detection based on two specific VEGF165 binding aptamers (Apt). VEGF is a predominant biomarker in cancer angiogenesis, and sensitive detection method of VEGF are highly demanded for both academic study and clinical diagnosis of multiple cancers. In our experiment, VEGF165 was captured in a sandwich structure assembled by two binding aptamers, one capture aptamer was immobilized on streptavidin-coated magnetic beads (MBs) and another VEGF-binding aptamer was labeled by biotin for further phosphatase conjunction...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28550813/a-reliable-sewage-quality-abnormal-event-monitoring-system
#7
Tianling Li, Melissa Winnel, Hao Lin, Jared Panther, Chang Liu, Roger O'Halloran, Kewen Wang, Taicheng An, Po Keung Wong, Shanqing Zhang, Huijun Zhao
With closing water loop through purified recycled water, wastewater becomes a part of source water, requiring reliable wastewater quality monitoring system (WQMS) to manage wastewater source and mitigate potential health risks. However, the development of reliable WQMS is fatally constrained by severe contamination and biofouling of sensors due to the hostile analytical environment of wastewaters, especially raw sewages, that challenges the limit of existing sensing technologies. In this work, we report a technological solution to enable the development of WQMS for real-time abnormal event detection with high reliability and practicality...
May 20, 2017: Water Research
https://www.readbyqxmd.com/read/28550683/oncogenic-role-of-microrna-30b-5p-in-glioblastoma-through-targeting-proline-rich-transmembrane-protein-2
#8
Zhongjun Li, Junxiu Guo, Yujie Ma, Zhixiong Lin, Longbo Zhang
MicroRNAs (miRs) have been found to play promoting or suppressive roles in different human cancers. However, the exactregulatory mechanism of miR-30b in glioblastoma still remains unknown. Here we showed that the expression of miR-30b was significantly increased in glioblastoma tissues and cell lines. Moreover, high expression of miR-30b was significantly associated with shorter survival time of glioblastoma patients. Knockdown of miR-30b caused a significant reduction in the proliferation, migration, and invasion of U87 and A172 cells...
May 17, 2017: Oncology Research
https://www.readbyqxmd.com/read/28550278/torsion-of-a-giant-antimesenteric-lipoma-of-the-ileum-a-rare-cause-of-acute-abdominal-pain
#9
Ta-Wei Yang, Yi-Wei Tsuei, Chung-Cheng Kao, Wen-Hsien Kuo, Yan-Lin Chen, Yen-Yue Lin
BACKGROUND Torsion of an intra-abdominal lipoma is rarely the cause of acute abdominal pain. Most of the previously reported cases of intra-abdominal lipoma torsion originated in the mesentery or omentum. However, an antimesenteric lipoma of the ileum with torsion has not been reported before. CASE REPORT A 67-year-old man presented to the emergency department with acute abdominal pain. Contrast-enhanced computed tomography (CECT) of the abdomen and pelvis only showed a giant fat-containing, soft-tissue, intra-abdominal tumor, suspected to be a lipoma...
May 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28550197/viral-rna-unprimed-rig-i-restrains-stat3-activation-in-the-modulation-of-regulatory-t-cell-th17-cell-balance
#10
Hui Yang, He-Zhou Guo, Xian-Yang Li, Jian Lin, Wu Zhang, Jun-Mei Zhao, Hong-Xin Zhang, Sai-Juan Chen, Zhu Chen, Jiang Zhu
Innate immunity activation by viral RNA-primed retinoid acid inducible gene-I (Rig-I) in CD4(+) T cells antagonizes TGFβ signaling to suppress the differentiation of regulatory T cells (Tregs). However, how viral RNA-unliganded Rig-I (apo-Rig-I) modulates Treg generation remains unclear. In this article, we show that, in the absence of viral infection, Treg differentiation of Rig-I(-/-) CD4(+) T cells was compromised, in the presence of increased generation of Th17 cells and overactivation of Stat3, a critical regulator tilting the Treg/Th17 cell balance...
May 26, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28550069/incidence-and-prevalence-of-nmosd-in-australia-and-new-zealand
#11
Wajih Bukhari, Kerri M Prain, Patrick Waters, Mark Woodhall, Cullen M O'Gorman, Laura Clarke, Roger A Silvestrini, Christine S Bundell, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J Brew, Matthew Brown, Wallace J Brownlee, Helmut Butzkueven, William M Carroll, Celia Chen, Alan Coulthard, Russell C Dale, Chandi Das, Keith Dear, Marzena J Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P D Henderson, Saman Heshmat, Suzanne Hodgkinson, Sofia Jimenez-Sanchez, Trevor Killpatrick, John King, Christopher Kneebone, Andrew J Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christpher Lynch, Richard Macdonell, Deborah F Mason, Pamela A McCombe, Michael P Pender, Jennifer A Pereira, John D Pollard, Stephen W Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C Wong, Eppie M Yiu, Michael H Barnett, Allan G Kermode, Mark P Marriott, John D E Parratt, Mark Slee, Bruce V Taylor, Ernest Willoughby, Robert J Wilson, Angela Vincent, Simon A Broadley
OBJECTIVES: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. BACKGROUND: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. METHODS: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD...
May 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28550026/localized-adult-ewing-sarcoma-favorable-outcomes-with-alternating-vincristine-doxorubicin-cyclophosphamide-and-ifosfamide-etoposide-vdc-ie-based-multimodality-therapy
#12
Jennifer L Pretz, Constance M Barysauskas, Suzanne George, Jason L Hornick, Chandrajit P Raut, Yen-Lin E Chen, Karen J Marcus, Edwin Choy, Francis Hornicek, John E Ready, Thomas F DeLaney, Elizabeth H Baldini
BACKGROUND: In children with localized Ewing sarcoma (ES), addition of ifosfamide and etoposide to cyclophosphamide, doxorubicin, and vincristine (VDC/IE) improved 5-year overall survival (OS) to 70%-80%. Prior to delivery of VDC/IE in adults, 5-year OS was <50%. We reviewed our institutional outcomes for adults with ES who received VDC/IE-based treatment. MATERIALS AND METHODS: Between 1997-2013, 67 adults with localized ES were treated with curative intent...
May 26, 2017: Oncologist
https://www.readbyqxmd.com/read/28549991/pancreatic-derived-factor-impaired-glucagon-like-peptide-1-production-from-glutag-enterendorine-l-cell-line-and-intestines
#13
Fenghua Lai, Yan Chen, Huimei Lin, Xuelan Wang, Xiaonan Zhu, Yanbing Li, Haipeng Xiao, Xiaopei Cao
PURPOSE: Pancreatic-derived factor (PANDER) is a pancreatic islet-specific cytokine that co-secretes with insulin. However, its biological function remains largely unknown. We have recently shown that the intestine might be its novel target tissue. The aim of this study was to clarify whether PANDER impacts the production of glucagon-like peptide-1 (GLP-1). METHODS: We treated GLUTag cells from the mouse intestine L cell line with recombinant PANDER protein and hepatic overexpression of PANDER in an obese murine model...
May 23, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28549941/dietary-zinc-deficiency-reduced-growth-performance-intestinal-immune-and-physical-barrier-functions-related-to-nf-%C3%AE%C2%BAb-tor-nrf2-jnk-and-mlck-signaling-pathway-of-young-grass-carp-ctenopharyngodon-idella
#14
Zheng-Xing Song, Wei-Dan Jiang, Yang Liu, Pei Wu, Jun Jiang, Xiao-Qiu Zhou, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
Our study investigated the effects of dietary zinc (Zn) deficiency on growth performance, intestinal immune and physical barrier functions of young grass carp (Ctenopharyngodon idella). A total of 630 grass carp (244.14 ± 0.40 g) were fed graded levels of zinc lactate (10.71, 30.21, 49.84, 72.31, 92.56, 110.78 mg Zn/kg diet) and one zinc sulfate group (56.9 mg Zn/kg diet) for 60 days. At the end of the feeding trial, fish were challenged with Aeromonas hydrophila for 14 days. These results indicated that compared with optimal dietary Zn level, dietary Zn deficiency (10...
May 23, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28549878/outbreak-of-imipenem-resistant-acinetobacter-baumannii-in-different-wards-at-a-regional-hospital-related-to-untrained-bedside-caregivers
#15
Ching-Hsun Wang, Jin-Feng Li, Li-Yueh Huang, Fu-Mei Lin, Ya-Sung Yang, L Kristopher Siu, Feng-Yee Chang, Jung-Chung Lin
BACKGROUND: This study describes an outbreak caused by imipenem-resistant Acinetobacter baumannii (IRAB) involving 2 general wards at the Penghu branch of Tri-Service General Hospital. METHODS: Clinical data obtained from the patients with IRAB during an outbreak from May 2014-October 2014 were reviewed. Microbiologic sampling from the environment and the hands of health care workers (HCWs) was performed. Clinical isolates from case patients were genotyped using pulsed-field gel electrophoresis (PFGE)...
May 23, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28549592/economic-outcomes-of-pharmacist-physician-medication-therapy-management-for-polypharmacy-elderly-a-prospective-randomized-controlled-trial
#16
Hsiang-Wen Lin, Chih-Hsueh Lin, Chin-Kai Chang, Che-Yi Chou, I-Wen Yu, Cheng-Chieh Lin, Tsai-Chung Li, Chia-Ing Li, Yow-Wen Hsieh
BACKGROUND/PURPOSE: With an increasing geriatric population, the need for effective management of chronic conditions and medication use in the elderly is growing. Medication use in the elderly presents significant challenges due to changes in pharmacodynamic and pharmacokinetic profiles. We aimed to examine the impact of a collaborative physician-pharmacist medication therapy management (MTM) program for polypharmacy elderly patients. METHODS: Elderly patients with multiple chronic conditions on polypharmacy were enrolled in this prospective, randomized, and controlled study over 16 months of implementation...
May 23, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28549591/single-allele-lmbrd1-knockout-results-in-cardiac-hypertrophy
#17
Linda Tzu-Ling Tseng, Chieh-Liang Lin, Kuei-Hsiang Pan, Kai-Yuan Tzen, Ming-Jai Su, Chia-Ti Tsai, Yi-Han Li, Pai-Chi Li, Fu-Tien Chiang, Shin C Chang, Ming-Fu Chang
BACKGROUND/PURPOSE: LMBD1 protein, a type IV-B plasma membrane protein possessing nine putative trans-membrane domains, was previously demonstrated at cellular level to play a critical part in the signaling cascade of insulin receptor through its involvement in regulating clathrin-mediated endocytosis. However, at physiological level, the significance of LMBD1 protein in cardiac development remains unclear. METHODS: To understand the role of Lmbrd1 gene involved in the cardiac function, heterozygous knockout mice were used as an animal model system...
May 23, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28549494/antimicrobial-susceptibility-testing-and-molecular-characterization-of-mycobacterium-fortuitum-isolates-in-china
#18
Hui Wen Zheng, Yu Pang, Guang Xue He, Yuan Yuan Song, Yan Lin Zhao
We performed molecular identification of clinical isolates of Mycobacterium fortuitum (M. fortuitum) and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. The results showed that moxifloxacin had the highest in vitro activity against M. fortuitum, and most M. fortuitum isolates were resistant to clarithromycin and linezolid in China. The loss of genetic mutation in clarithromycin- and amikacin-resistant isolates indicates that some other intrinsic mechanism conferring clarithromycin and amikacin resistance plays an essential role in M...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28549473/attitudes-of-consumers-and-live-poultry-workers-to-central-slaughtering-in-controlling-h7n9-a-cross-sectional-study
#19
Xiao Lin, Dingmei Zhang, Xinwei Wang, Yun Huang, Zhicheng Du, Yaming Zou, Jiahai Lu, Yuantao Hao
BACKGROUND: Guangdong Province in the Pearl River Delta of Southeast China is among the areas in the country with the highest rates of avian flu cases. In order to control the outbreak of human-infected H7N9 cases, Guangdong launched a new policy on the central slaughtering of live poultry in 2015. This study aims to evaluate attitudes of consumers and live-poultry workers toward the policy. The live-poultry workers consisted of two sub-groups: live-poultry traders and poultry farm workers...
May 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28549425/fast-and-robust-adjustment-of-cell-mixtures-in-epigenome-wide-association-studies-with-smartsva
#20
Jun Chen, Ehsan Behnam, Jinyan Huang, Miriam F Moffatt, Daniel J Schaid, Liming Liang, Xihong Lin
BACKGROUND: One problem that plagues epigenome-wide association studies is the potential confounding due to cell mixtures when purified target cells are not available. Reference-free adjustment of cell mixtures has become increasingly popular due to its flexibility and simplicity. However, existing methods are still not optimal: increased false positive rates and reduced statistical power have been observed in many scenarios. METHODS: We develop SmartSVA, an optimized surrogate variable analysis (SVA) method, for fast and robust reference-free adjustment of cell mixtures...
May 26, 2017: BMC Genomics
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