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https://www.readbyqxmd.com/read/27911278/meta-analysis-of-the-effects-of-oral-and-intravenous-dexamethasone-premedication-in-the-prevention-of-paclitaxel-induced-allergic-reactions
#1
Fu-Chao Chen, Lin-Hai Wang, Xiao-Yu Zheng, Xiu-Min Zhang, Jun Zhang, Lin-Jun Li
BACKGROUND: Dexamethasone premedication is required to prevent paclitaxel-related hypersensitivity reactions (HSRs). Oral dexamethasone (PO-D) has been considered the standard premedication regimen. However, whether intravenous dexamethasone (IV-D) is feasible for preventing paclitaxel-related HSRs is still unclear. We conducted a meta-analysis to compare these two regimens. METHODS: We performed a systematic search in the PubMed, China National Knowledge Infrastructure, and Web of Science databases for relevant articles published before June 2016...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911258/clostridium-guangxiense-sp-nov-and-clostridium-neuense-sp-nov-two-phylogenetically-closely-related-hydrogen-producing-species-isolated-from-lake-sediment
#2
Xin Zhao, Danyang Li, Shuhong Xu, Zhanghao Guo, Yan Zhang, Lin Man, Binhui Jiang, Xiaomin Hu
Two novel anaerobic, mesophilic, bio-hydrogen producing bacteria, designated strains ZGM211T and G1T, were isolated from lake sediment. 16S rRNA and ATP synthase beta subunit (atpD) gene sequences phylogenetic analysis of strains ZGM211T and G1T revealed an affiliation to the genus Clostridium sensu stricto (cluster I of the clostridia), with Clostridium acetobutylicum as the closest characterized species, showing the same sequence similarity of 96.4% to the type strain (98.9% between the two isolates). Cells of the two strains were rod-shaped...
December 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27911082/necrotizing-and-haemorrhagic-hepatitis-and-enteritis-in-commercial-layer-pullets
#3
Yuko Sato, William L Wigle, Tsang Long Lin, Eric Gingerich, Patricia S Wakenell
This case report describes an episode of recurring severe necrotizing and haemorrhagic hepatitis and enteritis experienced in a flock of commercial layer pullets at 12 weeks of age and again at 18 weeks of age in Indiana. Pullets had been vaccinated at 10 weeks old using a trivalent Salmonella Enteritidis (SE)/Newcastle disease/infectious bronchitis oil-emulsion-inactivated vaccine. The pullets were found dead at 12 weeks with firm but friable, enlarged, haemorrhagic livers, enlarged spleens, and necrohaemorrhagic intestines...
December 2, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27910970/exploration-of-hydrogen-bond-networks-and-potential-energy-surfaces-of-methanol-clusters-using-a-two-stage-clustering-algorithm
#4
Po-Jen Hsu, Kun-Lin Ho, Sheng-Hsien Lin, Jer-Lai Kuo
The potential energy surface (PES), structures and thermal properties of methanol clusters (MeOH)n with n = 8-15 were explored by replica-exchange molecular dynamics (REMD) simulations with an empirical model and refined using density functional theory (DFT) methods. For a given size, local minima structures were sampled from REMD trajectories and archived by a newly developed molecular database via a two-stage clustering algorithm (TSCA). Our TSCA utilizes both the topology of O-HO hydrogen bonding networks and the similarity of the shapes to filter out duplicates...
December 2, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27910866/biomechanical-analysis-of-normal-brain-development-during-the-first-year-of-life-using-finite-strain-theory
#5
Jeong Chul Kim, Li Wang, Dinggang Shen, Weili Lin
The first year of life is the most critical time period for structural and functional development of the human brain. Combining longitudinal MR imaging and finite strain theory, this study aimed to provide new insights into normal brain development through a biomechanical framework. Thirty-three normal infants were longitudinally imaged using MRI from 2 weeks to 1 year of age. Voxel-wise Jacobian determinant was estimated to elucidate volumetric changes while Lagrange strains (both normal and shear strains) were measured to reveal directional growth information every 3 months during the first year of life...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910702/a-new-isoquinolone-alkaloid-from-an-endophytic-fungus-r22-of-nerium-indicum
#6
Yang-Min Ma, Ke Qiao, Yang Kong, Meng-Yun Li, Lin-Xin Guo, Zhi Miao, Chao Fan
A new isoquinolone alkaloid named 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (3), together with two known quinolinone alkaloids 3-O-methylviridicatin (1) and viridicatol (2) were isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Their structures were elucidated by NMR, IR and MS data, and were also confirmed by comparing with the reported data in the literature. Meanwhile, the antibacterial and antifungal activities of all compounds were tested, and the results showed that three compounds had strong antifungal activity...
December 2, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27910403/a-new-nondestructive-instrument-for-bulk-residual-stress-measurement-using-tungsten-k%C3%AE-1-x-ray
#7
Ce Ma, Zuo-Yong Dou, Li Chen, Yun Li, Xiao Tan, Ping Dong, Jin Zhang, Lin Zheng, Peng-Cheng Zhang
We describe an experimental instrument used for measuring nondestructively the residual stress using short wavelength X-ray, tungsten kα1. By introducing a photon energy screening technology, the monochromatic X-ray diffraction of tungsten kα1 was realized using a CdTe detector. A high precision Huber goniometer is utilized in order to reduce the error in residual stress measurement. This paper summarizes the main performance of this instrument, measurement depth, stress error, as opposed to the neutron diffraction measurements of residual stress...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910245/anorectal-manometry-should-it-be-performed-in-a-seated-position
#8
G-J Wu, F Xu, L Lin, P J Pasricha, J D Z Chen
BACKGROUND: Anorectal manometry (ARM) is typically preformed in a lateral position. This non-physiological testing position has produced an unexpected negative rectoanal pressure gradient (RAPG, i.e. difference between rectal and anal pressure) with normal defecation. This study was designed (i) to study differences in ARM parameters between water-perfused and solid-state sensors and between lateral and seated positions and (ii) to investigate the roles of ARM parameters in predicting balloon expulsion...
December 1, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27910198/degradation-and-biocompatibility-of-photoembossed-plga-acrylate-blend-for-improved-cell-adhesion
#9
Nanayaa F Hughes-Brittain, Lin Qiu, Wen Wang, Ton Peijs, Cees W M Bastiaansen
We have shown previously that PMMA-acrylate photopolymers are biocomopatible and can exhibit improved cell adhesion compared to PMMA, due to an increase in negative surface charge caused by UV radiation PLGA has been used widely in soft tissue regeneration due to its high biocompatibility and cell adhesion. This polymer is also biodegradable and can be utilised in the field of vascular regeneration. In this study, PLGA is blended with a triacrylate monomer (TPETA) to create a degradable photopolymer blend. Surface relief structures are formed on this PLGA-TPETA by photoembossing...
December 2, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27910141/photocatalytic-hydrogen-evolution-driven-by-fefe-hydrogenase-models-tethered-to-fluorene-and-silafluorene-sensitizers
#10
Roman Goy, Luca Bertini, Tobias Rudolph, Shu Lin, Martin Schulz, Giuseppe Zampella, Benjamin Dietzek, Felix H Schacher, Luca De Gioia, Ken Sakai, Wolfgang Weigand
It is successfully shown that photocatalytic proton reduction to dihydrogen in the presence of a sacrificial electron donor, such as trimethylamine (TEA) and ascorbate, can be driven by compact sensitizer-catalyst dyads, that is, dithiolate-bridged [FeFe] hydrogenase models tethered to organic sensitizers, such as fluorenes and silafluorenes (1 a-4 a). The sensitizer-catalyst dyads 1 a-4 a show remarkable and promising catalytic activities as well as enhanced stabilities during photocatalysis performed under UV-light irradiation...
December 2, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27910002/the-rice-pentatricopeptide-repeat-gene-tcd10-is-needed-for-chloroplast-development-under-cold-stress
#11
Lanlan Wu, Jun Wu, Yanxia Liu, Xiaodi Gong, Jianlong Xu, Dongzhi Lin, Yanjun Dong
BACKGROUND: Chloroplast plays a vital role in plant development and growth. The pentatricopeptide repeat (PPR) gene family is one of the largest gene families in plants. In addition, cold stress affects a broad spectrum of cellular components, e.g. chloroplast, and metabolism in plants. However, the regulatory mechanism for rice PPR genes on chloroplast development still remains elusive under cold stress. RESULT: In this paper, we characterized a new rice PPR gene mutant tcd10 (thermo-sensitive chlorophyll-deficient mutant 10) that exhibits the albino phenotype, malformed chloroplast and could not survive after the 5-leaf stage when grown at 20 °C, but does the normal phenotype at 32 °C...
December 2016: Rice
https://www.readbyqxmd.com/read/27909731/hypoxia-drives-the-transition-of-human-dermal-fibroblasts-to-a-myofibroblast-like-phenotype-via-the-tgf-%C3%AE-1-smad3-pathway
#12
Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu
Keloids, partially considered as benign tumors, are characterized by the overgrowth of fibrosis beyond the boundaries of the wound and are regulated mainly by transforming growth factor (TGF)-β1, which induces the transition of fibroblasts to myofibroblasts. Hypoxia is an important driving force in the development of lung and liver fibrosis by activating hypoxia inducible factor-1α and stimulating epithelial‑mesenchymal transition. However, it is unknown whether and hypoxia can influence human dermal scarring...
December 1, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27909726/microrna%C3%A2-21-promotes-migration-and-invasion-of-glioma-cells-via-activation-of-sox2-and-%C3%AE-%C3%A2-catenin-signaling
#13
Guoxuan Luo, Wentao Luo, Xiaohui Sun, Jinzhi Lin, Mo Wang, Yang Zhang, Weishi Luo, Yong Zhang
The expression of microRNA 21 (miR-21) has been reported to be upregulated in various types of cancer, including malignant gliomas. However, its functions and mechanisms in glioma remain to be fully elucidated. The present study established miRNA‑21 overexpression and knockdown cell lines using SRY‑box 2 (Sox2) small interfering RNA (siRNA) to knockdown expression and Sox2 cDNA was cloned into pcDNA 3.1 mammalian expression vector for ectopic expression. BIO and XAV‑939 were used for β‑catenin signaling activation and knockdown, respectively...
November 28, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27909720/tetrandrine-inhibits-glioma-stem-like-cells-by-repressing-%C3%AE-catenin-expression
#14
Yong Zhang, Yu-Lin Wen, Ji-Wei Ma, Jie-Cheng Ye, Xiao Wang, Jian-Xian Huang, Chao-Yue Meng, Xiao-Ze Xu, Shao-Xiang Wang, Xue-Yun Zhong
Cancer stem cells (CSCs) in glioma are often responsible for relapse and resistance to therapy. The purpose of the present study was to confirm the self-renewal and migration inhibitory effects of tetrandrine (Tet), which is a compound extracted from the dried root of Stephania tetrandra S. Moore, toward glioma stem-like cells (GSLCs) and to examine the associated molecular mechanisms. Using a neurosphere culture technique, we enriched the GSLC population from the human glioblastoma cell lines U87 and U251...
November 23, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27909703/water-induced-helical-supramolecular-polymerization-and-gel-formation-of-an-alkylene-tethered-perylene-bisimide-dyad
#15
Xu Lin, Hiroki Kurata, Deepak D Prabhu, Mitsuaki Yamauchi, Tomonori Ohba, Shiki Yagai
An alkylene-tethered perylene bisimide (PBI) dyad with hydrophilic substituents forms helical supramolecular polymers that can be visualized by AFM in THF-water mixtures. The supramolecular polymers also form thixotropic gel-like lyotropic mesophases in the mixtures.
December 2, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27909065/cdk5-directly-targets-nuclear-p21cip1-and-promotes-cancer-cell-growth
#16
Pao-Hsuan Huang, Mei-Chih Chen, Yu-Ting Peng, Wei-Hsiang Kao, Chih-Hsiang Chang, Yun-Chi Wang, Chih-Ho Lai, Jer-Tsong Hsieh, Jo-Hsin Wang, Yueh-Tsung Lee, Eugene Lin, Chia-Herng Yue, Hsin-Yi Wang, Shuen-Chi You, Ho Lin
The significance of Cdk5 in cell-cycle control and cancer biology has gained increased attention. Here we report the inverse correlation between the protein levels of Cdk5 and p21(CIP1) from cell-based and clinical analysis. Mechanistically, we identify that Cdk5 overexpression triggers the proteasome-dependent degradation of p21(CIP1) through a S130 phosphorylation in a Cdk2-independent manner. Besides, the evidence from cell-based and clinical analysis shows that Cdk5 primarily regulates nuclear p21(CIP1) protein degradation...
December 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27909060/cd6-regulates-intestinal-ischemia-reperfusion-induced-injury-by-modulating-natural-igm-producing-b1a-cell-self-renewal
#17
Gospel Enyindah-Asonye, Yan Li, Wei Xin, Nora Singer, Neetu Gupta, John Fung, Feng Lin
Intestinal ischemia/reperfusion (I/R) injury is a relatively common pathological condition that can lead to multi-organ failure and mortality. Regulatory mechanism for this disease is poorly understood, although it is established that circulating pathogenic natural IgM, which is primarily produced by B1a cells outside of the peritoneal cavity, are integrally involved. CD6 was originally identified as a marker for T cells and later found to be present on some subsets of B cells in humans, however, whether CD6 plays any role in intestinal I/R induced injury and if so, what are the underlying mechanisms, remain unknown...
December 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27908880/an-anti-cd3-anti-cll-1-bispecific-antibody-for-the-treatment-of-acute-myeloid-leukemia
#18
Steven R Leong, Siddharth Sukumaran, Maria Hristopoulos, Klara Totpal, Shannon Stainton, Elizabeth Lu, Alfred Wong, Lucinda Tam, Robert Newman, Brian R Vuillemenot, Diego Ellerman, Chen Gu, Mary Mathieu, Mark S Dennis, Allen Nguyen, Bing Zheng, Crystal Zhang, Genee Lee, Yu-Waye Chu, Rodney A Prell, Kedan Lin, Steven T Laing, Andrew G Polson
Acute myeloid leukemia (AML) is major unmet medical need. Most patients have poor long-term survival and treatment has not significantly changed in 40 years. Recently, bispecific antibodies that redirect the cytotoxic activity of effector T-cells by binding to CD3, the signaling component of the T-cell receptor, and a tumor target have shown clinical activity. Notably, blinatumomab is approved to treat relapsed/refractory acute lymphoid leukemia. Here we describe the design, discovery, pharmacological activity, pharmacokinetics, and safety of a CD3 T-cell-dependent bispecific (TDB) full-length human IgG1 therapeutic antibody targeting CLL-1 that could potentially be used in humans to treat AML...
December 1, 2016: Blood
https://www.readbyqxmd.com/read/27908642/negative-regulation-of-nlrp3-inflammasome-by-sirt1-in-vascular-endothelial-cells
#19
Yanxiang Li, Xiaofeng Yang, Yanhao He, Weirong Wang, Jiye Zhang, Wei Zhang, Ting Jing, Bo Wang, Rong Lin
NLRP3 inflammasome not only functions as a critical effector in innate immunity, but also triggers the production of proinflammatory cytokines involved in inflammation-associated diseases. Sirtuin 1 (SIRT1) plays an important role in the regulation of cellular inflammation. However, whether the activation of NLRP3 inflammasome is regulated by SIRT1 remains unknown. In this study, we investigated the regulatory effect of SIRT1 on NLRP3 inflammasome and the underlying mechanisms. We found that lipopolysaccharide (LPS) and adenosine triphosphate (ATP)-induced the activation of NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)...
November 4, 2016: Immunobiology
https://www.readbyqxmd.com/read/27908612/polyvinyl-alcohol-terminal-chemoembolization-for-hepatocellular-carcinoma-with-hepatic-arteriovenous-shunts-safety-efficacy-and-prognostic-factors
#20
Qiu-Song Liu, Que-Lin Mei, Yan-Hao Li
PURPOSE: To evaluate the safety and efficacy of polyvinyl alcohol (PVA) terminal chemoembolization and to identify the prognostic factors associated with survival in hepatocellular carcinoma (HCC) patients with hepatic arteriovenous shunts (HAVS). MATERIALS AND METHODS: Of 133 patients' managements were retrospectively analyzed. HAVS was classified into three types: slow-flow, intermediate-flow and high-flow. The size of the PVA used was determined following the scheme: slow-flow HAVS: 300-500μm PVA; intermediate-flow HAVS: 500-710μm PVA; high-flow HAVS: 710-1000μm PVA...
April 30, 2016: European Journal of Radiology
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