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https://www.readbyqxmd.com/read/29650251/exploring-the-molecular-mechanisms-of-traditional-chinese-medicine-components-using-gene-expression-signatures-and-connectivity-map
#1
Minjae Yoo, Jimin Shin, Hyunmin Kim, Jihye Kim, Jaewoo Kang, Aik Choon Tan
BACKGROUND AND OBJECTIVE: Traditional Chinese Medicine (TCM) has been practiced over thousands of years in China and other Asian countries for treating various symptoms and diseases. However, the underlying molecular mechanisms of TCM are poorly understood, partly due to the "multi-component, multi-target" nature of TCM. To uncover the molecular mechanisms of TCM, we perform comprehensive gene expression analysis using connectivity map. METHODS: We interrogated gene expression signatures obtained 102 TCM components using the next generation Connectivity Map (CMap) resource...
April 4, 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29642967/heritability-of-cold-and-heat-patterns-a-twin-study
#2
Yoon-Mi Hur, Hana Yu, Hee-Jeong Jin, Siwoo Lee
In traditional East Asian medicine, cold-heat patterns have been widely used in the diagnosis and treatment of patients suffering from various diseases. The present study aimed to estimate the heritability of cold-heat patterns. Trained interviewers administered a cold-heat pattern questionnaire to 1,753 twins (mean age = 19.1 ± 3.1 years) recruited throughout South Korea. Correlations for the cold pattern (CP) were 0.42 (95% CI [0.28, 0.54]) for monozygotic (MZ) males, 0.16 (95% CI [-0.08, 0.39]) for dizygotic (DZ) males, 0...
April 12, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29629294/validity-of-yin-yang-temperament-in-sasang-personality-questionnaire
#3
Bo Kyung Hwang, Yeo-Jin Yoon, Sang Yun Han, Soo Jin Lee, Han Chae
Background: The Yin-Yang is a pivotal concept of traditional East-Asian medicine, however the stability of Yin-Yang temperament in Sasang Personality Questionnaire (SPQ) over time has not been extensively studied. The purpose of this study was to examine the test-retest validity of SPQ with a large number of participants. Methods: SPQ test was conducted two times with three months interval in 247 Korean university students. The structural validity of first SPQ data was examined with Factor analysis and Cronbach's alpha, and the correlation between first and second measure of SPQ was attested with Pearson's correlation...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29621184/the-flavonoid-isoquercitrin-precludes-initiation-of-zika-virus-infection-in-human-cells
#4
Arnaud Gaudry, Sandra Bos, Wildriss Viranaicken, Marjolaine Roche, Pascale Krejbich-Trotot, Gilles Gadea, Philippe Desprès, Chaker El-Kalamouni
The medical importance of Zika virus (ZIKV) was fully highlighted during the recent epidemics in South Pacific islands and Americas due to ZIKV association with severe damage to fetal brain development and neurological complications in adult patients. A worldwide research effort has been undertaken to identify effective compounds to prevent or treat ZIKV infection. Fruits and vegetables may be sources of compounds with medicinal properties. Flavonoids are one class of plant compounds that emerge as promising antiviral molecules against ZIKV...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29611498/survey-to-identify-substandard-and-falsified-tablets-in-several-asian-countries-with-pharmacopeial-quality-control-tests-and-principal-component-analysis-of-handheld-raman-spectroscopy
#5
Tomoko Kakio, Hitomi Nagase, Takashi Takaoka, Naoko Yoshida, Junichi Hirakawa, Susan Macha, Takashi Hiroshima, Yukihiro Ikeda, Hirohito Tsuboi, Kazuko Kimura
The World Health Organization has warned that substandard and falsified medical products (SFs) can harm patients and fail to treat the diseases for which they were intended, and they affect every region of the world, leading to loss of confidence in medicines, health-care providers, and health systems. Therefore, development of analytical procedures to detect SFs is extremely important. In this study, we investigated the quality of pharmaceutical tablets containing the antihypertensive candesartan cilexetil, collected in China, Indonesia, Japan, and Myanmar, using the Japanese pharmacopeial analytical procedures for quality control, together with principal component analysis (PCA) of Raman spectrum obtained with handheld Raman spectrometer...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29611024/anticancer-effect-of-fermented-insampaedok-san-in-human-colon-cancer-cells-a-pilot-study
#6
Hwayong Park, Kwang Dong Kim
Insampaedok-san (IPS) is one of the East Asian traditional medicines which have been prescribed for hundreds of years to treat common cold and headache. Although many herbs and prescriptions are known to have significant activities against diseases, only a limited number of reports and scientific evidences on their efficacies are available. To identify anticancer effect against colon cancer, traditional prescription IPS and its fermented IPS (FIPS) were examined by in vitro molecular biological analysis. IPS water extract was fermented, lyophilized, and examined by cytotoxicity, cell cycle, and western blot assays, using cancer cell lines...
April 2, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29610952/epicanthal-restoration-surgery-with-scar-excision-in-severe-epicanthal-scar
#7
Yoon Jae Chung, Mun Geun Koo, Soo Hyang Lee
BACKGROUND: Medial epicanthoplasty is a common aesthetic surgery in Asia to remove the epicanthal fold. With increasing use of this surgery, unsatisfactory results have grown. Several methods have been developed to correct it. However, there are limitations in restoration if the patient has a severe scar or does not have enough skin for reconstruction. By aggressively removing scar tissue, the authors present a better reverse redraping epicanthoplasty. METHODS: The procedure was performed on 512 patients who had complications of medial epicanthoplasty from May 2011 to October 2015...
April 2, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29595688/herbal-medicine-for-idiopathic-central-precocious-puberty-a-protocol-for-a-systematic-review-of-controlled-trials
#8
Hye Lim Lee, Yoo Been Lee, Jun-Yong Choi, Ju Ah Lee
BACKGROUND: Herbal medicine is widely used in East Asia to treat idiopathic central precocious puberty (ICPP). Most of the available clinical trials that investigated herbal medicine for ICPP have been included in this review. This systematic review will assess the efficacy and safety of herbal medicine for ICPP. METHODS: Eleven databases, including Asian databases, will be searched for studies conducted through 2018. We will include randomized controlled trials assessing herbal medicine for ICPP...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29578596/social-cultural-traditional-beliefs-and-health-system-barriers-of-hepatitis-b-screening-among-hmong-americans-a-case-study
#9
Dao M Fang, Susan L Stewart
BACKGROUND: The incidence of liver cancer in Hmong Americans is 5 times higher than that of non-Hispanic whites, and there is a low hepatitis B screening rate (24%) among Hmong adults compared with other Asian American populations. The purpose of this study was to examine the Hmong's perceptions on social-cultural determinants, traditional health beliefs, and health care system barriers that influenced community-based hepatitis B screening interventions. METHODS: A qualitative method was used, integrating a collective case study research design...
April 1, 2018: Cancer
https://www.readbyqxmd.com/read/29578001/long-term-administration-of-greek-royal-jelly-decreases-gaba-concentration-in-the-striatum-and-hypothalamus-of-naturally-aged-wistar-male-rats
#10
Justyna Pyrzanowska, Adriana Wawer, Ilona Joniec-Maciejak, Agnieszka Piechal, Kamilla Blecharz-Klin, Konstantia Graikou, Ioanna Chinou, Ewa Widy-Tyszkiewicz
Royal Jelly (RJ) is a unique substance obtained from bees that has been used widely in European and Asian traditional medicine for its potential to prevent signs of aging through its antioxidative, anti-inflammatory, anti-hyperglycemic and anti-hypercholesterolemic properties. We recently reported an enhancement in spatial memory along with changes in monoaminergic transmission in aged rats after chronic RJ administration. Here, we aim to further explore the action of RJ on central nervous system activity by examining levels of amino acids in selected brain structures of aged male Wistar rats following 2-months of Greek RJ administration...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29576797/inhibitory-effect-and-mechanism-of-arctium-lappa-extract-on-nlrp3-inflammasome-activation
#11
Young-Kyu Kim, Sushruta Koppula, Do-Wan Shim, Eun-Jung In, Su-Bin Kwak, Myong-Ki Kim, Sang-Hyeun Yu, Kwang-Ho Lee, Tae-Bong Kang
Arctium lappa (A. lappa) , Compositae, is considered a potential source of nutrition and is used as a traditional medicine in East Asian countries for centuries. Although several studies have shown its biological activities as an anti-inflammatory agent, there have been no reports on A. lappa with regard to regulatory role in inflammasome activation. The purpose of this study was to investigate the inhibitory effects of A. lappa extract (ALE) on NLRP3 inflammasome activation and explore the underlying mechanisms...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29576794/the-therapeutic-effects-of-a-traditional-chinese-medicine-formula-wuzi-yanzong-pill-for-the-treatment-of-oligoasthenozoospermia-a-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Ming Peng Zhao, Xiao Shi, Grace Wing Shan Kong, Chi Chiu Wang, Justin Che Yuen Wu, Zhi Xiu Lin, Tin Chiu Li, David Yiu Leung Chan
Oligoasthenozoospermia is a crucial factor in male infertility. Wuzi Yanzong (WZYZ) pill is a popular traditional Chinese medicine (TCM) formula which has been used for male infertility treatment for years. However, its effects on semen quality remain controversial. We conducted a preregistered meta-analysis to assess the effect of WZYZ pill for the therapeutic effects on oligoasthenozoospermia. Five randomized controlled trials including 960 participants were selected from databases of domains in North-East Asian regions, PubMed, Embase, and Cochrane Library...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29573719/anti-inflammatory-activity-of-mulberrofuran-k-isolated-from-the-bark-of-morus-bombycis
#13
Sun-Yup Shim, Sang Hyun Sung, Mina Lee
Morus bombycis Koidzumi, commonly known as silkworm mulberry, is a plant belonging to family Moraceae. It has been used in Asian countries as a traditional medicine for treating hypertension, diabetes, and inflammatory disorders. In this study, we isolated eleven compounds from the cortex of M. bombycis and evaluated their inhibitory effects on nitric oxide (NO) production as an indicator of their anti-inflammatory activities using lipopolysaccharide (LPS)-stimulated murine macrophages. Compound 4 showed the most potent inhibitory activity on NO production...
March 21, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29565194/survey-on-knowledge-attitude-acceptance-and-related-factors-among-pregnant-women-in-thailand-regarding-antenatal-thalassaemia-screening
#14
Tharangrut Hanprasertpong, Kasem Raungrongmorakot, Alan Geater, Pawin Puapornpong, Wipada Laosooksathit, Aurasa Hemachandra, Maysita Suksamarnwong
Thalassaemia is a common haematologic health condition in Southeast Asian countries (SEA) including Thailand. Reducing the birth of new thalassaemia cases is an effective method to control disease. The background level of knowledge and attitude of pregnant women on the disease influences their decision to perform antenatal screening. Unfortunately, the information about pregnant women's knowledge and attitude on antenatal thalassaemia screening in a developing country such as Thailand is lacking. We therefore conducted this cross-sectional study to examine patients' knowledge and to evaluate the factors which influence the patient's knowledge and attitude on antenatal thalassaemia screening...
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29561443/prognostic-and-clinicopathological-value-of-p16-protein-aberrant-expression-in-colorectal-cancer-a-prisma-compliant-meta-analysis
#15
Ning Zhou, Quankai Gu
PURPOSE: Several studies have examined the potential role of p16 protein expression as a diagnostic and prognostic biomarker in various cancers. However, it remains unclear whether p16 protein expression is a prognostic and diagnostic factor for colorectal cancer. Therefore, this meta-analysis is conducted to evaluate the associations of p16 protein expression with overall survival (OS) and clinicopathological characteristics of colorectal cancer. METHODS: According to PRISMA guideline, relevant literatures were identified by searching Medicine, Web of Science, WanFang, and CNKI databases...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29554880/underutilization-and-disparities-in-access-to-egfr-testing-among-medicare-patients-with-lung-cancer-from-2010-2013
#16
Julie A Lynch, Brygida Berse, Merry Rabb, Paul Mosquin, Rob Chew, Suzanne L West, Nicole Coomer, Daniel Becker, John Kautter
BACKGROUND: Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing. METHODS: We identified clinical, demographic, and regional predictors of EGFR & KRAS testing among Medicare beneficiaries with a new diagnosis of lung cancer in 2011-2013 claims...
March 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29552662/asian-consensus-guidelines-for-gastrointestinal-stromal-tumor-what-is-the-same-and-what-is-different-from-global-guidelines
#17
REVIEW
Toshirou Nishida
There are some disparities between the clinical practice and profiles of cancer in Asia and those in Europe & North America. In Asia, surgical oncologists still have a major role in the multidisciplinary therapy of gastrointestinal stromal tumor (GIST), whereas medical oncologists hold this status in the West. Although the incidence of clinical GIST is considered similar between the two areas, small gastric GISTs are more frequently treated by surgery in East Asia compared with Europe & North America...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29545148/de-novo-synthesis-of-the-sedative-valerenic-acid-in-saccharomyces-cerevisiae
#18
Jeff Wong, Leo d'Espaux, Ishaan Dev, Cas van der Horst, Jay Keasling
Valeriana officinalis (Valerian) root extracts have been used by European and Asian cultures for millennia for their anxiolytic and sedative properties. However, the efficacy of these extracts suffers from variable yields and composition, making these extracts a prime candidate for microbial production. Recently, valerenic acid, a C15 sesquiterpenoid, was identified as the active compound that modulates the GABAA channel. Although the first committed step, valerena-4,7(11)-diene synthase, has been identified and described, the complete valerenic acid biosynthetic pathway remains to be elucidated...
March 12, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29543756/estimating-genetic-conformism-of-korean-mulberry-cultivars-using-random-amplified-polymorphic-dna-and-inter-simple-sequence-repeat-profiling
#19
Sunirmal Sheet, Kuntal Ghosh, Satabdi Acharya, Kwang-Pyo Kim, Yang Soo Lee
Apart from being fed to silkworms in sericulture, the ecologically important Mulberry plant has been used for traditional medicine in Asian countries as well as in manufacturing wine, food, and beverages. Germplasm analysis among Mulberry cultivars originating from South Korea is crucial in the plant breeding program for cultivar development. Hence, the genetic deviations and relations among 8 Morus alba plants, and one Morus lhou plant, of different cultivars collected from South Korea were investigated using 10 random amplified polymorphic DNA (RAPD) and 10 inter-simple sequence repeat (ISSR) markers in the present study...
March 15, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29533838/morphology-of-glandular-trichomes-of-japanese-catnip-schizonepeta-tenuifolia-briquet-and-developmental-dynamics-of-their-secretory-activity
#20
Chanchan Liu, Narayanan Srividya, Amber N Parrish, Wei Yue, Mingqiu Shan, Qinan Wu, B Markus Lange
Schizonepeta tenuifolia Briquet, commonly known as Japanese catnip, is used for the treatment of colds, headaches, fevers, and skin rashes in traditional Asian medicine (China, Japan and Korea). The volatile oil and its constituents have various demonstrated biological activities, but there is currently limited information regarding the site of biosynthesis. Light microscopy and scanning electron microscopy indicated the presence of three distinct glandular trichome types which, based on their morphological features, are referred to as peltate, capitate and digitiform glandular trichomes...
March 10, 2018: Phytochemistry
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