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https://www.readbyqxmd.com/read/28087425/variations-of-metabolites-and-proteome-in-lonicera-japonica-thunb-buds-and-flowers-under-uv-radiation
#1
Wei Zhu, Wen Zheng, Xingjiang Hu, Xiaobao Xu, Lin Zhang, Jingkui Tian
Lonicera japonica Thunb., also known as Jin Yin Hua and Japanese honeysuckle, is used as a herbal medicine in Asian countries. Its flowers have been used in folk medicine in the clinic and in making food or healthy beverages for over 1500years in China. To investigate the molecular processes involved in L. japonica development from buds to flowers exposed to UV radiation, a comparative proteomics analysis was performed. Fifty-four proteins were identified as differentially expressed, including 42 that had increased expression and 12 that had decreased expression...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28069798/integrative-comparison-of-mrna-expression-patterns-in-breast-cancers-from-caucasian-and-asian-americans-with-implications-for-precision-medicine
#2
Yanxia Shi, Albert Steppi, Ye Cao, Jianan Wang, Max M He, Liren Li, Jinfeng Zhang
Asian Americans (AS) have significantly lower incidence and mortality rates of breast cancer than Caucasian Americans (CA). Although this racial disparity has been documented, the underlying pathogenetic factors explaining it are obscure. We addressed this issue by an integrative genomics approach to compare mRNA expression between AS and CA cases of breast cancer. RNA-seq data from the Cancer Genome Atlas showed that mRNA expression revealed significant differences at gene and pathway levels. Increased susceptibility and severity in CA patients were likely the result of synergistic environmental and genetic risk factors, with arachidonic acid metabolism and PPAR signaling pathways implicated in linking environmental and genetic factors...
November 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/28062967/septal-cartilage-ethmoid-bone-composite-graft-a-new-and-improved-method-for-the-correction-underdeveloped-nasal-septum-in-patients-with-short-noses
#3
Soo Hyang Lee, Mun Geun Koo, Eun Taek Kang
BACKGROUND: Septal extension grafts are an effective means of extending nasal length in patients with a short nose. However, such grafts can be challenging in patients who only have small quantities of weak septal cartilage, such as some East Asian patients. We developed a rhinoplasty technique using ethmoid bone to create a cartilage-bone complex to overcome this issue, allowing adequate nasal lengthening. METHODS: Sixty-four women with short noses and inadequate septal cartilage determined by preoperative computed tomography underwent septal extension grafting with a cartilage-bone complex between January 2009 and December 2014...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28051024/association-of-chronic-kidney-disease-with-coronary-heart-disease-and-stroke-risks-in-patients-with-type-2-diabetes-mellitus-an-observational-cross-sectional-study-in-hangzhou-china
#4
Xue Sun, Jie He, Xiao-Li Ji, Yi-Ming Zhao, Han-Yu Lou, Xiao-Xiao Song, Li-Zhen Shan, Ying-Xiu Kang, Wen-Heng Zeng, Xiao-Hong Pang, Song-Zhao Zhang, Yue Ding, Yue-Zhong Ren, Peng-Fei Shan
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD). However, the association between CKD and CVD risk in patients with type 2 diabetes mellitus (T2DM) in China has not yet been well investigated. This study aimed to determine the association of CKD with the risks of coronary heart disease (CHD) and stroke in a Chinese population with T2DM. METHODS: A total of 1401 inpatients with T2DM at the Second Affiliated Hospital of Zhejiang University School of Medicine between April 2008 and November 2013 were included in this study...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28039500/objective-outcome-measurement-after-upper-blepharoplasty-an-analysis-of-different-operative-techniques
#5
Ki-Soo Park, David Dae-Hwan Park
BACKGROUND: Upper blepharoplasty is indicated in Asians for double-eyelid fold creation, periorbital rejuvenation, and functional visual field improvement. This article introduces a technical classification for blepharoplasty methods and investigates approaches to evaluate its outcomes. METHODS: Of 535 patients undergoing aesthetic upper blepharoplasty in our institution in 1998-2011, 136 patients who were well followed up were retrospectively reviewed and categorized into four groups according to the techniques employed...
December 30, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28034659/toxins-and-pharmacologically-active-compounds-from-species-of-the-family-bufonidae-amphibia-anura
#6
REVIEW
Candelario Rodríguez, Louise Rollins-Smith, Roberto Ibáñez, Armando A Durant-Archibold, Marcelino Gutiérrez
ETHNOPHARMACOLOGICAL RELEVANCE: Among amphibians, 15 of the 47 species reported to be used in traditional medicines belong to the family Bufonidae, which demonstrates their potential in pharmacological and natural products research. For example, Asian and American tribes use the skin and the parotoid gland secretions of some common toads in the treatment of hemorrhages, bites and stings from venomous animals, skin and stomach disorders, as well as several types of cancers. OVERARCHING OBJECTIVE: In addition to reviewing the occurrence of chemical constituents present in the family Bufonidae, the cytotoxic and biomedical potential of the active compounds produced by different taxa are presented...
December 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28011655/cross-national-differences-in-the-holistic-use-of-traditional-east-asian-medicine-in-east-asia
#7
Jae-Mahn Shim, Jibum Kim
Complementary and alternative medicine (CAM) has been one of the popular strategies for health promotion. Traditional East Asian medicine (TEAM) is one of the most popular CAM practices in the world and there are suggestions that its holistic utilization is important for users to gain its effects for health promotion. In this context, this study investigates the extent to which TEAM users in East Asian countries utilize various modalities of TEAM holistically. It provides a model that explains cross-national differences in the extent of the holistic use of TEAM between China, Japan, Korea and Taiwan...
December 23, 2016: Health Promotion International
https://www.readbyqxmd.com/read/28008813/evaluation-of-anticholinesterase-and-inflammation-inhibitory-activity-of-medicinal-mushroom-phellinus-pini-basidiomycetes-fruiting-bodies
#8
Kyung Hoan Im, Trung Kien Nguyen, Jae Kwang Kim, Jae-Hyuk Choi, Tae Soo Lee
Phellinus pini, a medicinal mushroom, has been used as folk medicine in Asian countries for treating ailments such as cancer and gastrointestinal diseases. In this study we evaluated in vitro the antidementia and anti-inflammatory activities of Ph. Pini fruiting bodies. Eleven phenol compounds were detected by high-performance liquid chromatography analysis. Acetylcholinesterase and butyrylcholinesterase inhibitory effects of a methanol extract and a hot water extract were moderate and comparable with those of galanthamine, the standard drug used to treat the early stages of Alzheimer's disease...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28007527/applications-of-higenamine-in-parmacology-and-medicine
#9
REVIEW
Nana Zhang, Zeqin Lian, Xueying Peng, Zijian Li, Haibo Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum has been used as local and traditional medicines in many asian regions for the treatment of various diseases such as collapse, syncope, painful joints, oedema, bronchial asthma et al. Higenamine, a plant-based alkaloid, was initially isolated from Aconitum and identified as the active cardiotonic component of Aconitum. It has been tested as a candidate of pharmacologic stress agent in the detection of coronary artery diseases (CADs) and now researchers have just accomplished the phase III clinical studies successfully in China...
December 19, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28004778/glycosides-from-edible-sea-cucumbers-stimulate-macrophages-via-purinergic-receptors
#10
Dmitry Aminin, Evgeny Pislyagin, Maxim Astashev, Andrey Es'kov, Valery Kozhemyako, Sergei Avilov, Elena Zelepuga, Ekaterina Yurchenko, Leonid Kaluzhskiy, Emma Kozlovskaya, Alexis Ivanov, Valentin Stonik
Since ancient times, edible sea cucumbers have been considered a jewel of the seabed and used in Asian folk medicine for stimulation of resistance against different diseases. However, the power of this sea food has not been established on a molecular level. A particular group of triterpene glycosides was found to be characteristic metabolites of the animals, responsible for this biological action. Using one of them, cucumarioside A2-2 (CA2-2) from the edible Cucumaria japonica species as an example as well as inhibitory analysis, patch-clamp on single macrophages, small interfering RNA technique, immunoblotting, SPR analysis, computer modeling and other methods, we demonstrate low doses of CA2-2 specifically to interact with P2X receptors (predominantly P2X4) on membranes of mature macrophages, enhancing the reversible ATP-dependent Ca(2+) intake and recovering Ca(2+) transport at inactivation of these receptors...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000097/an-overview-of-epigenetics-in-chinese-medicine-researches
#11
REVIEW
Xue-Qing Hu, Shi-Bing Su
Chinese medicine (CM) has contributed to human health care for several thousand years and is still popular in Asian countries. But the mechanisms underlying CM remain obscure, and need to be clarified by modern biological subjects and methods. Recently, CM researches on epigenetics have gained obvious improvement following rapidly developed molecular technologies. In this review, we revealed mutual characteristics of epigenetics and CM, such as holism, yin-yang dynamic nature, reversibility and balance, and visceral manifestation...
December 20, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27998330/medical-science-meets-development-aid-transfer-and-adaptation-of-west-german-microbiology-to-togo-1960-1980
#12
Carola Rensch, Walter Bruchhausen
After losing the importance it had held around 1900 both as a colonial power and in the field of tropical medicine, Germany searched for a new place in international health care during decolonisation. Under the aegis of early government 'development aid', which started in 1956, medical academics from West German universities became involved in several Asian, African and South American countries. The example selected for closer study is the support for the national hygiene institute in Togo, a former German 'model colony' and now a stout ally of the West...
January 2017: Medical History
https://www.readbyqxmd.com/read/27994979/diet-of-the-endangered-big-headed-turtle-platysternon-megacephalum
#13
Yik-Hei Sung, Billy C H Hau, Nancy E Karraker
Populations of the big-headed turtle Platysternon megacephalum are declining at unprecedented rates across most of its distribution in Southeast Asia owing to unsustainable harvest for pet, food, and Chinese medicine markets. Research on Asian freshwater turtles becomes more challenging as populations decline and basic ecological information is needed to inform conservation efforts. We examined fecal samples collected from P. megacephalum in five streams in Hong Kong to quantify the diet, and we compared the germination success of ingested and uningested seeds...
2016: PeerJ
https://www.readbyqxmd.com/read/27991533/distinct-urine-metabolome-after-asian-ginseng-and-american-ginseng-intervention-based-on-gc-ms-metabolomics-approach
#14
Liu Yang, Qing-Tao Yu, Ya-Zhong Ge, Wen-Song Zhang, Yong Fan, Chung-Wah Ma, Qun Liu, Lian-Wen Qi
Ginseng occupies a prominent position in the list of best-selling natural products worldwide. Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius) show different properties and medicinal applications in pharmacology, even though the main active constituents of them are both thought to be ginsenosides. Metabolomics is a promising method to profile entire endogenous metabolites and monitor their fluctuations related to exogenous stimulus. Herein, an untargeted metabolomics approach was applied to study the overall urine metabolic differences between Asian ginseng and American ginseng in mice...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27989874/effect-of-diabetea-tea-tm-consumption-on-inflammatory-cytokines-and-metabolic-biomarkers-in-type-2-diabetes-patients
#15
Fadia Mahmoud, Ebaa Al-Ozairi, David Haine, Ladislav Novotny, Ali Dashti, Basel Ibrahim, Mohamed Abdel-Hamid
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetea tea (TM) (DT) is an anti-diabetic alternative medicine in some Asian countries. The main constituent of DT is black tea originating from Camellia sinensis that is supplemented by 12 other medicinal plants. Black tea contains a large amount of the flavonoids catechins especially epigallocatechin gallate (EGCG) which has anti-inflammatory and antioxidative capacity. This study was undertaken to evaluate the possible effects of DT intake on inflammatory cytokines, regulatory T cells (Tregs) and metabolic biomarkers in T2DM...
October 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27986566/a-flavanone-derivative-from-the-asian-medicinal-herb-perilla-frutescens-potently-suppresses-ige-mediated-immediate-hypersensitivity-reactions
#16
Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto
Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P...
December 13, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27983571/anti-fatigue-effects-of-small-molecule-oligopeptides-isolated-from-panax-ginseng-c-a-meyer-in-mice
#17
Lei Bao, Xiaxia Cai, Junbo Wang, Yuan Zhang, Bin Sun, Yong Li
Panax ginseng C. A. Meyer (ginseng) is an edible and medicinal Chinese herb, which is often used in Asian countries for physical fitness. Ginseng is reported to have a wide range of biological activity and pharmaceutical properties. There were more studies on ginsenosides and polysaccharides, but fewer studies on ginseng oligopeptides (GOP), which are small molecule oligopeptides isolated from ginseng. The present study was designed to evaluate the anti-fatigue effects of GOP in mice and explore the possible underlying mechanism...
December 13, 2016: Nutrients
https://www.readbyqxmd.com/read/27975130/does-alcohol-consumption-modify-the-risk-of-endometrial-cancer-a-dose-response-meta-analysis-of-prospective-studies
#18
Quan Zhou, Peng Guo, Hui Li, Xiao-Dan Chen
BACKGROUND: Epidemiological studies have provided controversial evidence of an association between alcohol intake and endometrial cancer (EC) risk. The World Cancer Research Fund/American Institute for Cancer Research classifies alcohol as having a "limited-no conclusion" grade of evidence in the Endometrial Cancer 2013 Report (the latest version). OBJECTIVE: The purpose of this meta-analysis is to systematically analyze the effect of alcohol intake on EC risk. METHODS: We conducted a dose-response meta-analysis of prospective cohort studies identified from the PubMed, Embase, Cochrane Library and China Biological Medicine databases...
December 14, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27956904/antibacterial-action-of-curcumin-against-staphylococcus-aureus-a-brief-review
#19
REVIEW
Sin-Yeang Teow, Kitson Liew, Syed A Ali, Alan Soo-Beng Khoo, Suat-Cheng Peh
Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family) or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against Staphylococcus aureus (S. aureus). As demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27933711/using-a-co-production-prioritization-exercise-involving-south-asian-children-young-people-and-their-families-to-identify-health-priorities-requiring-further-research-and-public-awareness
#20
Logan Manikam, Rakhee Shah, Kate Reed, Gupreet Santini, Monica Lakhanpaul
OBJECTIVES: To facilitate South Asian (SA) families and health-care professionals (HCPs) participation in a prioritization exercise to co-produce child health research and public awareness agendas. DESIGN: A three-stage process was adopted involving the following: (i) systematic literature review, (ii) HCP scoping survey and (iii) focus groups of SA adolescents and families. A Punjabi- and Urdu-speaking community facilitator moderated focus groups. A British Sign Language interpreter assisted in the hard of hearing group...
December 8, 2016: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
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