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https://www.readbyqxmd.com/read/27910789/methoxyflavones-from-new-lingzhi-medicinal-mushroom-ganoderma-lingzhi-agaricomycetes
#1
Kuniyoshi Shimizu, Yhiya M Amen, Satoru Kaifuchi
Ganoderma lingzhi is one of the most famous medicinal fungi in the world. It has been used in folk medicine, especially in East Asian countries. It is also a white-rot fungus with strong wood degradation ability, especially against lignin. Different classes of bioactive natural products have been reported in Ganoderma, including triterpenes, polysaccharides, sterols, and peptides. The triterpenes and polysaccharides are the primary bioactive compounds of Ganoderma. We report for the first time the presence of 3 methoxyflavones as minor constituents in G...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910771/induction-of-flavin-containing-monooxygenase-in-mice-by-oral-administration-of-phellinus-baumii-agaricomycetes-extract
#2
Batbayar Sainkhuu, Beom Su Park, Ha Won Kim
Phellinus baumii is a yellow mushroom long used in alternative medicine in Korea and other central Asian countries. To identify genes affected by a single or 7-day oral administration of a water extract of Ph. Baumii, mouse liver tissue was analyzed using microarrays. The results showed that 8 and 23 genes were upregulated and 3 and 11 genes downregulated more than 3-fold by single and multiple oral administrations of 100 mg/kg PBE, respectively. Among the upregulated genes, the expression of 3 flavin-containing monooxygenase (Fmo) family genes, Fmo2-4, was upregulated in a concentration-dependent manner...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910755/comparison-of-the-composition-and-antioxidant-activities-of-phenolics-from-the-fruiting-bodies-of-cultivated-asian-culinary-medicinal-mushrooms
#3
Shaoling Lin, Lai Tsz Ching, Xinxin Ke, Peter Chi Keung Cheung
The composition profile and the antioxidant properties of phenolics in water extracts obtained from the fresh fruiting bodies of 4 common cultivated Asian edible mushrooms-Agrocybe aegerita, Pleurotus ostreatus, P. eryngii, and Pholiota nameko were compared. The water extract from A. aegerita (AaE) had the highest total phenolic content (TPC) at 54.18 ± 0.27 gallic acid equivalents (μmol/L)/mg extract (P < 0.05), as measured by the Folin-Ciocalteu method, and consisted of the largest number (including gallic acid, protocatechuic acid, chlorogenic acid, ferulic acid, and sinapic acid) and total amounts of phenolic acids identified by Fourier transform-ion cyclotron resonance mass spectrometry...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27888134/perilla-frutescens-leaves-extract-ameliorates-ultraviolet-radiation-induced-extracellular-matrix-damage-in-human-dermal-fibroblasts-and-hairless-mice-skin
#4
Jung-Soo Bae, Mira Han, Hee Soon Shin, Min-Kyoung Kim, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
ETHNOPHARMACOLOGICAL RELEVANCE: Perilla frutescens (L.) Britt. (Lamiaceae) is a traditional herb that is consumed in East Asian countries as a traditional medicine. This traditional herb has been documented for centuries to treat various diseases such as depression, allergies, inflammation and asthma. However, the effect of Perilla frutescens on skin has not been characterized well. AIM OF THE STUDY: The present study aimed to investigate the effect of Perilla frutescens leaves extract (PLE) on ultraviolet radiation-induced extracellular matrix damage in human dermal fibroblasts and hairless mice skin...
November 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27884853/gyejibongneyong-hwan-a-herbal-medicine-for-the-treatment-of-dysmenorrhoea-with-uterine-fibroids-a-protocol-for-a-randomised-controlled-trial
#5
Jeeyoun Jung, Ju Ah Lee, Mi Mi Ko, Sooseong You, Eunhee Lee, Jiae Choi, Byoung-Kab Kang, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), or the Guizhi Fuling Formula in Chinese, is widely used to treat uterine fibroids in East Asian countries including Korea, China and Japan. This study will assess the efficacy and safety of the GBH formula for the treatment of dysmenorrhoea. METHODS AND ANALYSIS: This study will be a randomised double-blind controlled trial with two parallel arms: the GBH group and the placebo group. This trial will recruit 38 women between 18 and 45 years of age with secondary dysmenorrhoea with uterine fibroids...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27881215/birth-of-an-asian-cool-reference-genome-ak1
#6
Changhoon Kim
The human reference genome, maintained by Genome Reference Consortium, is conceivably the most complete genome assembly ever since its first construction. It has been improved continually by incorporating corrections made to the previous assemblies thanks to various technological advances. Based on this reference genome, many population sequencing projects are ongoing to better represent human diversity, increasing hope for medical usage of genomic information, with recent maturation of the high-throughput sequencing technologies...
November 24, 2016: BMB Reports
https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#7
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27878246/luteolin-protects-mice-from-severe-acute-pancreatitis-by-exerting-ho-1-mediated-anti-inflammatory-and-antioxidant-effects
#8
Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, acute lung injury, acute myocardial infarction and hepatitis. Luteolin, the main component of Reseda odorata L., which is also widely found in many natural herbs and vege-tables, has been shown to induce heme oxygenase-1 (HO-1) expression to exert anti-inflammatory and antioxidant effects. In this study, we aimed to examine the effects of luteolin on mice with severe acute pancreatitis (SAP), and to explore the underlying mechanisms...
November 22, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27861942/the-ectopic-accessory-parotid-system-with-congenital-cheek-fistula-an-overview-and-current-update
#9
REVIEW
Mainak Dutta
OBJECTIVE: This review attempts to provide a comprehensive, updated overview of the ectopic accessory parotid system (EAPS) from clinical and developmental perspectives and investigates its eligibility to be included in the oculo-auriculo-vertebral spectrum (OAVS). REVIEW METHODS: Results of the keyword-based search in the PubMed/MEDLINE, Google Scholar, LILACS, and Cochrane Library were subjected to the given inclusion and exclusion criteria that corroborated with the definition of EAPS...
November 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853051/expression-efficiency-of-nat2-haplotypes-in-a-korean-population
#10
Han Sung Na, Jin Sol Lee, Hyun Sub Cheong, Hee Jung Shin, Tae Sun Kang, Hyun Joo Park, Hyoung Doo Shin, Myeon Woo Chung
Since NAT2 single-nucleotide polymorphisms (SNPs) are responsible for the efficacy of arylamines and hydrazine drugs, defining the effects of these SNPs in various ethnicities is an important factor in the development of personalized medicine. In the present study, we examined the expression efficiency of NAT2 using promoter haplotypes identified in a Korean population. To construct NAT2 promoter haplotypes, seven NAT2 promoter SNPs (rs4646241, rs4646242, rs4646243, rs4646267, rs4345600, rs4271002, and rs4646246) were genotyped in a total of 192 Korean subjects...
November 15, 2016: Genes & Genetic Systems
https://www.readbyqxmd.com/read/27835996/developing-precision-medicine-for-people-of-east-asian-descent
#11
REVIEW
Stacy L McAllister, Katherine Sun, Eric R Gross
The goal of precision medicine is to separate patient populations into groups to ultimately provide customized care tailored to patients. In terms of precision medicine, ~540 million people in the world have a genetic variant of the aldehyde dehydrogenase 2 (ALDH2) enzyme causing a flushing response and tachycardia after alcohol consumption. The genetic variant is identified as ALDH2*2 and originates from East Asian descendants of the Han Chinese. The variant is particularly important to consider when discussing lifestyle choices with patients in terms of risk for developing specific diseases, preventative screening, and selection of medications for treatment...
November 11, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27829842/the-role-of-anethum-graveolens-l-dill-in-the-management-of-diabetes
#12
REVIEW
Mohammad Taghi Goodarzi, Iraj Khodadadi, Heidar Tavilani, Ebrahim Abbasi Oshaghi
Aim. There is evidence that Anethum graveolens (AG) has been used for centuries in Asian traditional medicine, and its constituents have useful effects on the control and management of diabetes and cardiovascular disorders. AG has many useful effects, including hypolipidemic and hypoglycemic effects, and it has been reported to reduce the incidence of diabetic complications. It acts mainly by affecting antioxidant capacity and change in some genes in glucose and lipid pathways. The aim of the present paper was to summarize pharmacological effects of AG in the management of diabetes...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27818698/relationship-of-the-cold-heat-sensation-of-the-limbs-and-abdomen-with-physiological-biomarkers
#13
Duong Duc Pham, JeongHoon Lee, GaYul Kim, JiYeon Song, JiEun Kim, Chae Hun Leem
The present study explored the relationship between the regional Cold-Heat sensation, the key indicator of the Cold-Heat patterns in traditional East Asian medicine (TEAM), and various biomarkers in Korean population. 734 apparently healthy volunteers aged 20 years and older were enrolled. Three scale self-report questions on the general thermal feel in hands, legs, and abdomen were examined. We found that 65% of women tended to perceive their body, particularly their hands and legs, to be cold, versus 25% of men...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27816645/stereospecificity-of-ginsenoside-rg2-epimers-in-the-protective-response-against-uv-b-radiation-induced-oxidative-stress-in-human-epidermal-keratinocytes
#14
Hyun-Ji Kang, Yu-Hua Huang, Hye-Won Lim, Daehyun Shin, Kyounghee Jang, Yoonjin Lee, Kyunghoon Kim, Chang-Jin Lim
Ginseng, referring to the dried roots of Panax ginseng C.A. Meyer, has been known as a famous traditional folkloric medicine in East Asian countries for a long time. In recent years, it has been gaining a worldwide popularity as a dietary herbal supplement. Ginsenosides are bioactive ingredients that are responsible for most pharmacological efficacies of ginseng. Ginsenoside Rg2 (Rg2), one of minor protopanaxatriol (PPT)-type ginsenosides, exists in two epimeric forms, 20(S)-ginsenoside Rg2 [20(S)-Rg2] and 20(R)-ginsenoside Rg2 [20(R)-Rg2]...
October 29, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27816466/lysine-and-cysteine-based-protein-adductions-derived-from-toxic-metabolites-of-8-epidiosbulbin-e-acetate
#15
Dongju Lin, Kai Wang, Xiucai Guo, Huiyuan Gao, Ying Peng, Jiang Zheng
Furanoid 8-epidiosbulbin E acetate (EEA) is a major constituent of herbal medicine Dioscorea bulbifera L. (DB), a traditional herbal medicine widely used in Asian nations. Our early studies demonstrated that administration of EEA caused acute hepatotoxicity in mice and the observed toxicity required P450-mediated metabolic activation. Protein modification by reactive metabolites of EEA has been suggested to be an important mechanism of EEA-induced hepatotoxicity. The objectives of the present study were to investigate the interaction of the electrophilic reactive metabolites derived from EEA with lysine and cysteine residues of proteins and to define the correlation of protein adductions of EEA and the hepatotoxicity induced by EEA...
November 2, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27812646/one-year-after-the-zika-virus-outbreak-in-brazil-from-hypotheses-to-evidence
#16
Carlos Alexandre Antunes de Brito, Marli Tenorio Cordeiro
Zika virusis an arbovirus of the Flaviviridae family with two major strains, an Asian and an African strain. The main vectors involved in the transmission of Zika virus are the Aedes aegypti and Aedes albopictus mosquitoes. Despite its identification, discovered in 1947 in the Zika forest in Uganda, only isolated and sporadic occurrences of human infection were reported within a largely asymptomatic proportion of individuals. The first reported outbreak occurred in 2007 in the Yap Island, which belongs to the Federated States of Micronesia in the Pacific Ocean, and in French Polynesia, where high attack rates occurred and the first cases of associated Guillain-Barré syndrome were reported...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27809637/anthocyanin-rich-black-soybean-testa-improved-visceral-fat-and-plasma-lipid-profiles-in-overweight-obese-korean-adults-a-randomized-controlled-trial
#17
Myoungsook Lee, Sungbin Richard Sorn, Yongsoon Park, Hoon-Ki Park
Anthocyanin-rich black soybeans have been used in traditional East Asian medicine to cure diseases related to oxidative stress and carcinogens, but not obesity. Our objective was to investigate the effects of anthocyanin-rich black soybean testa extracts (BBT), Glycine max (Chongja No. 3), on obesity. In total, 63 participants defined as overweight or obese by their body mass index (BMI >23) or waist circumference (WC >90 cm for males, >85 cm for females) were sorted into two groups: 32 receiving the trial medication (BBT, 2...
November 3, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27806312/systematic-approach-identifies-rhoa-as-a-potential-biomarker-therapeutic-target-for-asian-gastric-cancer
#18
Hae Ryung Chang, Seungyoon Nam, Jinhyuk Lee, Jin-Hee Kim, Hae Rim Jung, Hee Seo Park, Sungjin Park, Young Zoo Ahn, Iksoo Huh, Curt Balch, Ja-Lok Ku, Garth Powis, Taesung Park, Jin-Hyun Jeong, Yon Hui Kim
Gastric cancer (GC) is a highly heterogeneous disease, in dire need of specific, biomarker-driven cancer therapies. While the accumulation of cancer "Big Data" has propelled the search for novel molecular targets for GC, its specific subpathway and cellular functions vary from patient to patient. In particular, mutations in the small GTPase gene RHOA have been identified in recent genome-wide sequencing of GC tumors. Moreover, protein overexpression of RHOA was reported in Chinese populations, while RHOA mutations were found in Caucasian GC tumors...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27802903/dendrobium-officinale-kimura-et-migo-attenuates-diabetic-cardiomyopathy-through-inhibiting-oxidative-stress-inflammation-and-fibrosis-in-streptozotocin-induced-mice
#19
Zhihao Zhang, Duoduo Zhang, Mengmeng Dou, Zhubo Li, Jie Zhang, Xiaoyan Zhao
Dendrobium officinale Kimura et Migo (Dendrobium catenatum Lindley), a prized traditional Chinese Medicine, has been used in China and Southeast Asian countries for centuries. The present study was aimed to investigate the effects and the possible mechanisms of the Dendrobium officinale extracts (DOE) on diabetic cardiomyopathy in mice. The diabetic model was induced by intraperitoneal injection of streptozotocin at the dose of 50mg/kg body weight for 5 consecutive days. After 8 weeks treatment of DOE, mice were sacrificed, blood sample and heart tissues were collected...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27795255/complete-chloroplast-genome-sequence-of-dendrobium-nobile-from-northeastern-india
#20
Ruchishree Konhar, Devendra Kumar Biswal, Manish Debnath, Sriram Parameswaran, Durai Sundar, Pramod Tandon
The orchid species Dendrobium nobile belonging to the family Orchidaceae and genus Dendrobium (a vast genus that encompasses nearly 1,200 species) has an herbal medicinal history of about 2000 years in east and south Asian countries. Here, we report the complete chloroplast genome sequence of D. nobile from northeastern India for the first time.
October 6, 2016: Genome Announcements
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