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https://www.readbyqxmd.com/read/29470395/therapeutic-potential-of-oridonin-and-its-analogs-from-anticancer-and-antiinflammation-to-neuroprotection
#1
REVIEW
Jimin Xu, Eric A Wold, Ye Ding, Qiang Shen, Jia Zhou
Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29468518/cultural-factors-influencing-osteoarthritis-care-in-asian-communities-a-review-of-the-evidence
#2
REVIEW
Thrmiga Sathiyamoorthy, Shabana Amanda Ali, Marita Kloseck
With the prevalence of osteoarthritis (OA) increasing internationally, there is a need to study the impact of this disease on culturally diverse populations. Individuals of Asian descent make up more than 60% of the world population, yet comprehensive information on the cultural factors that impact OA care is not available. Scoping review methodology using directed content analysis was employed to identify and analyze existing research on OA care for Asians. A categorization matrix was developed using the six care areas from the OA clinical practice guidelines along with an additional three non-clinical areas (cross-cultural adaptation of clinical tools; psychological well-being; family systems and informal care) identified in an initial scan resulting in a total of nine OA care areas to guide initial coding...
February 21, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29462501/preparation-and-preliminary-in-vivo-evaluation-of-166-ho-labeled-microspheres-for-possible-use-in-radio-embolic-therapy-of-liver-cancer
#3
Suresh Subramanian, K V Vimalnath, Ashutosh Dash
Hepatocellular carcinoma (HCC) or liver cancer is an increasingly prevalent and highly morbid disease with critical significance in the Asian and African sub-continents. Among the various therapies currently employed in the clinic to combat the global menace of HCC, radio-embolization with suitable therapeutic isotopes is an effective targeted approach. In the Indian context, the significant cost and logistical disadvantage of imported radio-embolic formulations for HCC therapy make it essential to develop more feasible indigenous alternatives - using locally available radioisotopes and microspheric carriers - that can serve the nuclear medicine community...
February 20, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29459880/molecular-phylogeny-and-dating-of-forsythieae-oleaceae-provide-insight-into-the-miocene-history-of-eurasian-temperate-shrubs
#4
Young-Ho Ha, Changkyun Kim, Kyung Choi, Joo-Hwan Kim
Tribe Forsythieae (Oleaceae), containing two genera ( Abeliophyllum and Forsythia ) and 13 species, is economically important plants used as ornamentals and in traditional medicine. This tribe species occur primarily in mountainous regions of Eurasia with the highest species diversity in East Asia. Here, we examine 11 complete chloroplast genome and nuclear cycloidea2 ( cyc2 ) DNA sequences of 10 Forsythia species and Abeliophyllum distichum using Illumina platform to provide the phylogeny and biogeographic history of the tribe...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29458925/is-cupping-blister-harmful-a-proteomical-analysis-of-blister-fluid-induced-by-cupping-therapy-and-scald
#5
Zhidan Liu, Chunlan Chen, Xiaoyan Li, Chuang Zhao, Zunyuan Li, Wei Liang, Yufang Lin
OBJECTIVE: Cupping therapy has a long history in traditional medicine especially in Asian countries. It was controversial whether cupping induced blisters are beneficial to healing effects, and the formation and content in the blisters remain unexplored. We aimed to identify and compare the molecular components of the blister fluid from the cupping therapy and the scalds to explore the necessary of inducing cupping induced blisters. METHODS: Fluid sample of blisters from fifteen patients receiving cupping therapy (Cupping group) and scald burns (Scald group) were collected in this study...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29451901/the-novel-antibiotic-rhodomyrtone-traps-membrane-proteins-in-vesicles-with-increased-fluidity
#6
Dennapa Saeloh, Varomyalin Tipmanee, Kin Ki Jim, Marien P Dekker, Wilbert Bitter, Supayang P Voravuthikunchai, Michaela Wenzel, Leendert W Hamoen
The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many studies have demonstrated its antibacterial potential in a variety of clinical applications, very little is known about the mechanism of action of rhodomyrtone. Preceding studies have been focused on intracellular targets, but no specific intracellular protein could be confirmed as main target. Using live cell, high-resolution, and electron microscopy we demonstrate that rhodomyrtone causes large membrane invaginations with a dramatic increase in fluidity, which attract a broad range of membrane proteins...
February 16, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29451882/de-novo-transcriptomic-analysis-of-leaf-and-fruit-tissue-of-cornus-officinalis-using-illumina-platform
#7
Dian-Yun Hou, Lin-Chun Shi, Meng-Meng Yang, Jiong Li, Shuang Zhou, Hong-Xiao Zhang, Hua-Wei Xu
Cornus officinalis is one of the most widely used medicinal plants in China and other East Asian countries to cure diseases such as liver, kidney, cardiovascular diseases and frequent urination for thousands of years. It is a Level 3 protected species, and is one of the 42 national key protected wild species of animals and plants in China. However, the genetics and molecular biology of C. officinalis are poorly understood, which has hindered research on the molecular mechanism of its metabolism and utilization...
2018: PloS One
https://www.readbyqxmd.com/read/29445170/brm270-inhibits-cancer-stem-cell-maintenance-via-microrna-regulation-in-chemoresistant-a549-lung-adenocarcinoma-cells
#8
Taeho Kwon, Nisansala Chandimali, Do Luong Huynh, Jiao Jiao Zhang, Nameun Kim, Yesol Bak, Do-Young Yoon, Dae-Yeul Yu, Jae Cheol Lee, Meeta Gera, Mrinmoy Ghosh, Yang Ho Park, Dong Kee Jeong
Chemotherapy is a standard treatment for non-small-cell lung cancer (NSCLC). However, the dose-limiting toxicity of drugs and the development of chemoresistance are major clinical challenges to successful management of NSCLC. Asian traditional medicine is gaining global attention as a non-toxic alternative to chemotherapy. BRM270 is an extract formulated from seven Asian medicinal plants that has been shown to inhibit tumor cell proliferation in diverse cancer types. We previously demonstrated that BRM270 suppresses tumorigenesis by negatively regulating nuclear factor-κB signaling in multidrug-resistant cancer stem cells (CSCs)...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29441675/uterine-adenosarcoma-in-japan-clinicopathologic-features-diagnosis-and-management
#9
Keisei Tate, Reiko Watanabe, Hiroshi Yoshida, Hanako Shimizu, Takashi Uehara, Mitsuya Ishikawa, Shun-Ichi Ikeda, Nobuyoshi Hiraoka, Tomoyasu Kato
AIM: Uterine adenosarcoma is a rare malignancy with limited cohort data in Asian countries. This study evaluated the clinicopathologic features of Japanese patients with uterine adenosarcoma and their potential treatment challenges. METHODS: A retrospective chart review was performed at the National Cancer Center Hospital, Japan from 2000 to 2016. A literature search for Japanese cases of uterine adenosarcoma was conducted using PubMed, Japanese Central Review of Medicine, and the Annual of Pathological Autopsy Cases in Japan...
February 14, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29440905/clinical-predictive-score-of-intracranial-hemorrhage-in-mild-traumatic-brain-injury
#10
Chaiyaporn Yuksen, Yuwares Sittichanbuncha, Jayanton Patumanond, Sombat Muengtaweepongsa, Kittisak Sawanyawisuth
Background: Mild traumatic brain injury (TBI) is a common condition at the Emergency Medicine Department. Head computer tomography (CT) scans in mild TBI patients must be properly justified in order to avoid unnecessary exposure to X-rays and to reduce the hospital/transfer costs. This study aimed to evaluate which clinical factors are associated with intracranial hemorrhage in Asian population and to develop a user-friendly predictive model. Methods: The study was conducted retrospectively at the Emergency Medicine Department in Ramathibodi Hospital, a university-affiliated super tertiary care hospital in Bangkok, Thailand...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29436677/-retracted-apogossypolone-inhibits-the-proliferation-of-lncap-cells-in%C3%A2-vitro-and-in%C3%A2-vivo
#11
Xianqing Zhang, Xingbin Hu, Shijie Mu, Yonghua Zhan, Qunxing An, Zhixin Liu, Xiaofeng Huang
An interested reader drew to the attention of the Editorial Board of Molecular Medicine Reports that certain data in the above paper had already been published in a previous study featuring several of the same authors [Zhang XQ, Huang XF, Hu XB, Zhan YH, An QX, Yang SM, Xia AJ, Yi J, Chen R, Mu SJ and Wu DC: "Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro". Asian J Androl 12: 697-708, 2010]. Specifically, Figs...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29432855/suppression-of-lung-inflammation-by-the-methanol-extract-of-spilanthes-acmella-murray-is-related-to-differential-regulation-of-nf-%C3%AE%C2%BAb-and-nrf2
#12
Kyun Ha Kim, Eun Jung Kim, Min Jung Kwun, Ji Yeon Lee, Tran The Bach, Sang Mi Eum, Jun Yong Choi, Sayeon Cho, Sang-Jun Kim, Seung-Il Jeong, Myungsoo Joo
ETHNOPHARMACOLOGICAL RELEVANCE: Although Spilanthes acmella has been used to relieve inflammation, fever, pain, or infection in traditional Asian medicine, experimental evidence supporting these functions is scarce. Here, we examined an anti-inflammatory function and a possible underlying mechanism of S. acmella Murray (SAM). MATERIALS AND METHOD: The methanol extract of SAM was fingerprinted by HPLC. C57BL/6 mice were administered with a single intratracheal (i...
February 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29425651/astragaloside-vi-and-cycloastragenol-6-o-beta-d-glucoside-promote-wound-healing-in-vitro-and-in-vivo
#13
Shih-Yu Lee, Wen-Liang Chang, Zhi-Xiang Li, Nicholas S Kirkby, Wei-Cheng Tsai, Shu-Fen Huang, Ching-Huei Ou, Tsu-Chung Chang
BACKGROUND: Astragalus genus includes most of the common, historical herbal medicines that have various applications in Asian countries. However, clinical data and mechanistic insights into their actions are still lacking. PURPOSE: In this study, we aimed to examine the effects of astragalosides on wound healing in vitro and in vivo, as well as the underlying mechanisms of these actions. METHODS: The wound healing activity of astragalosides was investigated in human HaCaT keratinocytes, human dermal fibroblast (HDF) cells, and murine models of wound healing...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29421594/dna-damaging-potential-of-ganoderma-lucidum-extracts
#14
María Soledad Vela Gurovic, Fátima R Viceconte, Marcelo T Pereyra, Maximiliano A Bidegain, María Amelia Cubitto
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Lingzhi or Reishi) is a medicinal mushroom historically used in Asian countries to treat a wide variety of diseases and prolong life. In the last years, G. lucidum has been internationally recognized as an effective adjuvant in cancer treatment. Among active components, the most recent research indicates that polysaccharides modulate the immune response favoring the recovery from toxicity of chemo and radiotherapy while triterpenes are cytotoxic to tumoral cells mainly by altering gene expression...
February 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29415715/hospital-acquired-fever-in-oriental-medical-hospitals
#15
Soo-Youn Moon, Ki-Ho Park, Mi Suk Lee, Jun Seong Son
BACKGROUND: Traditional Oriental medicine is used in many Asian countries and involves herbal medicines, acupuncture, moxibustion, and cupping. We investigated the incidence and causes of hospital-acquired fever (HAF) and the characteristics of febrile inpatients in Oriental medical hospitals (OMHs). METHODS: Patients hospitalized in two OMHs of a university medical institute in Seoul, Korea, were retrospectively reviewed from 2006 to 2013. Adult patients with HAF were enrolled...
February 7, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29414842/chemical-constituents-and-pharmacological-activity-of-agarwood-and-aquilaria-plants
#16
REVIEW
Shuai Wang, Zhangxin Yu, Canhong Wang, Chongming Wu, Peng Guo, Jianhe Wei
Agarwood, a highly precious non-timber fragrant wood of Aquilaria spp. (Thymelaeaceae), has been widely used in traditional medicine, religious rites, and cultural activities. Due to the inflated demanding and depleted natural resources, the yields of agarwood collected from the wild are shrinking, and the price is constantly rising, which restricts agarwood scientific research and wide application. With the sustainable planting and management of agarwood applied, and especially the artificial-inducing methods being used in China and Southeast Asian countries, agarwood yields are increasing, and the price is becoming more reasonable...
February 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29407176/assessing-the-safety-of-an-ephedrae-herba-aqueous-extract-in-rats-a-repeat-dose-toxicity-study
#17
Hyoung-Yun Han, Jung-Im Huh, So-Ri Han, Myung-Gyun Kang, Seokjoo Yoon, Ji-Seok Han, Byoung-Seok Lee, Jeong Ah Kim, Byung-Sun Min
Ephedrae Herba (EH) has been used in Asian traditional herbal medicine to cure bronchial asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. In this study, we evaluated the subchronic toxicity of an Ephedrae Herba aqueous extract (EHAE) in male and female F344 rats. The EHAE was administered orally daily at doses of 0, 125, 250, 500, and 1000 mg/kg bw/day for 13 weeks. Toxicological assessment was performed to determine mortality, clinical signs, and changes in body weight, food consumption, ophthalmological, urinary, hematological, and serum biochemical parameters, macroscopic and microscopic evaluations, and organ weights...
January 30, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29390928/association-of-vascular-endothelial-growth-factor-vegf-gene-polymorphisms-with-gastric-cancer-and-its-development-prognosis-and-survival
#18
Weimin Liu, Zhiyong Dong, Ruixiang Hu, Cunchuan Wang
The relationship between vascular endothelial growth factor gene polymorphism and gastric cancer risk and its development, prognosis, and survival are still being debated. This meta-analysis was performed to assess these relationships. The association reports were identified from PubMed, Embase, Cochrane Library, and CBM-disc (China Biological Medicine Database), and eligible studies were included and calculated using the meta-analysis method. VEGF+936C/T, VEGF+405 G>C, VEGF-460 T>C, VEGF-1498 T>C, and VEGF-2578 C>A gene polymorphisms were found to be unassociated with gastric cancer risk for the overall population in this meta-analysis, whereas the VEGF-634 G>C GG genotype was associated with gastric cancer risk in the overall population...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29389573/investigation-of-borneols-sold-in-taiwan-by-chiral-gas-chromatography
#19
Tsung-Jung Ho, Chien-Che Hung, Tzenge-Lien Shih, Lih-Ming Yiin, Hao-Ping Chen
Borneol is a monoterpene that is widely used in traditional Chinese medicine. There are two different products sold in Taipei's traditional Chinese medicine market, natural and chemically synthesized borneol. Chemically synthesized borneol contains four stereoisomers, (+)-isoborneol, (-)-isoborneol, (-)-borneol, and (+)-borneol. The ratio of these four isomers in chemically synthesized and natural borneol products was determined by gas chromatography mass spectrometry. A huge variation between these products is highlighted in this survey...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29386454/-importance-of-an-aldehyde-dehydrogenase-2-polymorphism-in-preventive-medicine
#20
Akiko Matsumoto
Unlike genetic alterations in other aldehyde dehydrogenase (ALDH) isozymes, a defective ALDH2 polymorphism (rs671), which is carried by almost half of East Asians, does not show a clear phenotype such as a shortened life span. However, impacts of a defective ALDH2 allele, ALDH2*2, on various disease risks have been reported. As ALDH2 is responsible for the detoxification of endogenous aldehydes, a negative effect of this polymorphism is predicted, but bidirectional effects have been actually observed and the mechanisms underlying such influences are often complex...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
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