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https://www.readbyqxmd.com/read/28818768/novel-gomisin-b-analogues-as-potential-cytotoxic-agents-design-synthesis-biological-evaluation-and-docking-studies
#1
B Poornima, Bandi Siva, A Venkanna, G Shankaraiah, Nishant Jain, Dharmendra Kumar Yadav, Sanjeev Misra, K Suresh Babu
As part of pharmacological-phytochemical integrated studies on medicinal flora, Gomisin B (1) was isolated as major phytochemical lead from schisandra grandiflora, a plant traditionally used in different Asian systems of medicine. A series of 1,2,3-triazoles derivatives were synthesized at the C-7' position of the gomisin B core through diastereoselective Michael addition followed by regioselective Huisgen 1,3-dipolar cycloaddition reactions. All these triazolyl derivatives (5a-5q) were well characterized using modern spectroscopic techniques and evaluated for their anti-cancer activity against a panel of five human cancerous cell-lines...
August 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28814115/neuraminidase-inhibitory-activity-by-compounds-isolated-from-aerial-parts-of-rhinacanthus-nasutus
#2
Hee Jae Kwak, SeonJu Park, Nanyoung Kim, Guijae Yoo, Jun Hyung Park, Youngse Oh, Nguyen Xuan Nhiem, Seung Hyun Kim
Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of various diseases, such as cancer, fungal infections, herpes virus infections and several types of skin diseases in South-East Asian countries. In this study, eight compounds 1-8 were isolated from the aerial parts of R. nasutus. The structures of compounds were determined by the spectroscopic methods, including 1D and 2D NMR. The isolated compounds were evaluated for neuraminidase inhibitory activity. Several lignans, 2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-1,4-butanediol (5) and 8,8'-bisdihydrosiringenin glucoside (6), significantly inhibited neuraminidase activity, which was comparable to the positive controls, mangiferin and oseltamivir...
August 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28811395/overview-and-reflections-of-a-new-experimental-community-pharmacy-internship-module-for-undergraduate-pharmacy-students-in-western-nepal
#3
Sangita Timsina, Bhuvan K C, Dristi Adhikari, Alian A Alrasheedy, Mohamed Izham Mohamed Ibrahim, Atisammodavardhana Kaundinnyayana
The community pharmacies in Nepal and other South Asian countries is in a mediocre state due to poor regulation and the pharmacies being run by people with short training on dispensing. This has led to inappropriate use of medicines. The problem due to poor regulation and mediocre state of community pharmacies in South Asia encompasses both academia and practice. In this paper, the two-week community pharmacy internship programme of the two pharmacy graduating students of Pokhara University (Nepalese public university) at Sankalpa Pharmacy, Pokhara, Nepal is illustrated...
August 16, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28807841/racial-disparity-in-gastrointestinal-cancer-risk
#4
REVIEW
Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers
Cancer from the gastrointestinal tract and its associated excretory organs will occur in over 300,000 Americans in 2017, with colorectal cancer responsible for over forty percent of that burden; there will be over 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to these cancers' incidence and mortality exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in Non-Hispanic Whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among Blacks...
August 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28807165/effect-and-mechanism-of-chinese-herbal-medicine-on-parkinson-s-disease
#5
Bai-Yun Zeng
Parkinson's disease is a progressive neurodegenerative disorder. Although both genetic and environmental factors are implicated in the development of Parkinson's disease, the cause of the disease is still unclear. So far conventional treatments to Parkinson's are symptomatic relief and focused mainly on motor symptoms. Chinese herbal medicine has been used to treat many conditions in China, Korea, Japan, and many Southeast Asian countries for 1000 years. During past a few decades, Chinese herbal medicine has gained wider and increasing acceptance within both public and medical profession due to its effectiveness on many conditions in western countries...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28801989/determination-of-higenamine-and-coclaurine-levels-in-human-urine-after-the-administration-of-a-throat-lozenge-containing-nandina-domestica-fruit
#6
Masato Okano, Mitsuhiko Sato, Shinji Kageyama
Higenamine is a key component of traditional Chinese herbal medicine. The fruit of Nandina domestica (which contains this component) is available as an ingredient in the so-called Nanten-nodo-ame throat lozenge found on the Japanese market, which is an over-the-counter pharmaceutical and is easy to purchase for Japanese athletes. However, higenamine is a non-selective β2-agonist, which is exemplified in the prohibited list of the World Anti-Doping Agency (WADA). Therefore, some have raised a concern regarding the potential cause of increased unintentional higenamine doping cases in the Asian region...
August 12, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28798405/progress-in-genome-wide-association-studies-of-schizophrenia-in-han-chinese-populations
#7
REVIEW
Weihua Yue, Xin Yu, Dai Zhang
Since 2006, genome-wide association studies of schizophrenia have led to the identification of numerous novel risk loci for this disease. However, there remains a geographical imbalance in genome-wide association studies, which to date have primarily focused on Western populations. During the last 6 years, genome-wide association studies in Han Chinese populations have identified both the sharing of susceptible loci across ethnicities and genes unique to Han Chinese populations. Here, we review recent progress in genome-wide association studies of schizophrenia in Han Chinese populations...
August 10, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28793356/potential-anti-inflammatory-sesquiterpene-lactones-from-eupatorium-lindleyanum
#8
Fang Wang, Huanhuan Zhong, Shiqi Fang, Yunfeng Zheng, Cunyu Li, Guoping Peng, Xinchun Shen
Eupatorium lindleyanum has traditionally been used as folk medicine in Asian countries for its therapeutic effects on tracheitis and tonsillitis. Investigation of the anti-inflammatory active constituents from E. lindleyanum led to the isolation of two novel sesquiterpene lactones, named eupalinolide L (1) and eupalinolide M (2), and seven known sesquiterpene lactones (3-9). The structures and configurations of the new compounds were determined on the basis of spectroscopic analysis, especially 2D NMR techniques...
August 9, 2017: Planta Medica
https://www.readbyqxmd.com/read/28777980/fatty-acid-profiling-and-multivariate-analysis-in-the-genus-leucas-reveals-its-nutritional-pharmaceutical-and-chemotaxonomic-significance
#9
Ashish Kumar Choudhary, P Sunojkumar, Girish Mishra
Genus Leucas with about 41 species found in India, is an Asian genus with separation from its close relatives in Africa based on phylogenetic evidence. Present study represents the only comprehensive phytochemical investigation on this genus. We have analyzed the seed fatty acid compositions of 26 species and five varieties of Leucas for nutritional, pharmaceutical and chemotaxonomic perspectives. The fatty acids and their composition in seeds of Leucas species, collected from different geographical regions in India, were analyzed by gas chromatography and mass spectrometry...
August 1, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28771352/human-gastrointestinal-metabolism-of-the-cistanches-herba-water-extract-in-vitro-elucidation-of-the-metabolic-profile-based-on-comprehensive-metabolite-identification-in-gastric-juice-intestinal-juice-human-intestinal-bacteria-and-intestinal-microsomes
#10
Yang Li, Ying Peng, Mengyue Wang, Pengfei Tu, Xiaobo Li
Cistanches Herba is taken orally as a health food supplement and medicinal plant in Asian countries. It consists of the stems of Cistanche deserticola (CD) and Cistanche tubulosa (CT). The gastrointestinal metabolism of the multiple components contained in Cistanches Herba is crucial for the discovery of bioactive constituents. This study aims to elucidate the comprehensive metabolic profile of the Cistanches Herba water extract by simulating human gastrointestinal metabolism in vitro independently and sequentially using four models: gastric juice, intestinal juice, human intestinal bacteria, and human intestinal microsomes...
August 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28769804/metabolomics-and-integrative-omics-for-the-development-of-thai-traditional-medicine
#11
REVIEW
Sakda Khoomrung, Kwanjeera Wanichthanarak, Intawat Nookaew, Onusa Thamsermsang, Patcharamon Seubnooch, Tawee Laohapand, Pravit Akarasereenont
In recent years, interest in studies of traditional medicine in Asian and African countries has gradually increased due to its potential to complement modern medicine. In this review, we provide an overview of Thai traditional medicine (TTM) current development, and ongoing research activities of TTM related to metabolomics. This review will also focus on three important elements of systems biology analysis of TTM including analytical techniques, statistical approaches and bioinformatics tools for handling and analyzing untargeted metabolomics data...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28764139/atlantooccipital-fusion-prevalence-and-its-developmental-and-clinical-correlation
#12
D K Sharma, Deepak Sharma, Vandana Sharma
INTRODUCTION: Atlantooccipital fusion or occipitalization of atlas or assimilation of atlas is a rare or uncommon abnormality recorded in anatomical, morphological and radiological studies. It is usually associated with reduction in dimensions of foramen magnum leading to acute or chronic neurovascular compression and clinical manifestations of varying severity. Though, atlantooccipital fusion is rare but it is important and significant for the physicians and surgeons for their diagnostic and therapeutic approach...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762049/biogenic-synthesis-of-gold-nanoparticles-from-terminalia-arjuna-bark-extract-assessment-of-safety-aspects-and-neuroprotective-potential-via-antioxidant-anticholinesterase-and-antiamyloidogenic-effects
#13
Natarajan Suganthy, Vijayan Sri Ramkumar, Arivalagan Pugazhendhi, Giovanni Benelli, Govindaraju Archunan
The development of neuroprotective drugs through eco-friendly production routes is a major challenge for current pharmacology. The present study was carried out to synthesize gold nanoparticles (AuNPs) through biogenic route using ethanolic bark extract of Terminalia arjuna, a plant of high interest in Asian traditional medicine, and to evaluate its neuroprotective effects. The synthesized AuNPs were characterized by UV-Vis spectroscopy, FTIR spectroscopy, XRD, FESEM, EDX, HRTEM, DLS, and zeta potential analyses...
July 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28761790/potential-wound-healing-activity-of-quercus-infectoria-formulation-in-diabetic-rats
#14
Julalak Chokpaisarn, Sasitorn Chusri, Thanaporn Amnuaikit, Wandee Udomuksorn, Supayang Piyawan Voravuthikunchai
BACKGROUND: Quercus infectoria G. Olivier (Fagaceae) nutgalls have been widely employed in traditional Asian medicine for several treatments, especially wounds and skin disorders. However, the effects of this plant on wound healing have not yet been clearly elucidated. This present work was focused on utilization of Quercus infectoria (Qi) as a topical agent for chronic wound treatment. METHODS: Twenty Qi formulations (QiFs) were pharmaceutically formulated and antibacterial activity of all formulations was performed...
2017: PeerJ
https://www.readbyqxmd.com/read/28758107/ganoderma-spp-a-promising-adjuvant-treatment-for-breast-cancer
#15
Ivette J Suárez-Arroyo, Yaliz Loperena-Alvarez, Raysa Rosario-Acevedo, Michelle M Martínez-Montemayor
For the past several decades, cancer patients in the U.S. have chosen the use of natural products as an alternative or complimentary medicine approach to treat or improve their quality of life via reduction or prevention of the side effects during or after cancer treatment. The genus Ganoderma includes about 80 species of mushrooms, of which several have been used for centuries in traditional Asian medicine for their medicinal properties, including anticancer and immunoregulatory effects. Numerous bioactive compounds seem to be responsible for their healing effects...
March 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28756527/synergistic-tumor-suppression-by-a-perilla-frutescens-derived-methoxyflavanone-and-anti-cancer-tyrosine-kinase-inhibitors-in-a549-human-lung-adenocarcinoma
#16
Amer Ali Abd El-Hafeez, Takashi Fujimura, Rikiya Kamei, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Seiji Kawamoto
Anti-cancer tyrosine kinase inhibitors (TKIs) are effective in many types of cancers including non-small cell lung cancer, while appearance of TKI-resistant tumors suggests a need for the development of their potentiation strategies. We have previously shown that a methoxyflavanone derivative from the Asian medicinal herb Perilla frutescens (Perilla-derived methoxyflavanone; PDMF) shows a prominent anti-tumor activity against A549 human lung adenocarcinoma. Here we show that PDMF and anti-cancer TKIs (nilotinib, bosutinib, dasatinib, and ponatinib) synergistically suppress proliferation of A549 cells...
July 29, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28755972/anoectochilus-roxburghii-a-review-of-its-phytochemistry-pharmacology-and-clinical-applications
#17
REVIEW
Shenyi Ye, Qingsong Shao, Ailian Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Anoectochilus roxburghii (Orchidaceae), also known as Jinxianlian (Simplified Chinese: ) and Jinxianlan (Simplified Chinese: ), is valued in many Asian countries, where this plant species is used for medicinal, culinary, and ornamental purposes. As a food, A. roxburghii is widely used as a treatment booster and medicine because of its various beneficial properties; these include, most notably, the curative effects of heat dissipation and cooling of blood, elimination of dampness, detoxification, and immunity enhancement...
July 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28749854/risk-stratification-in-pediatric-acute-respiratory-distress-syndrome-a-multicenter-observational-study
#18
Judith Ju-Ming Wong, Huu Phuc Phan, Suwannee Phumeetham, Jacqueline Soo May Ong, Yek Kee Chor, Suyun Qian, Rujipat Samransamruajkit, Nattachai Anantasit, Chin Seng Gan, Feng Xu, Rehena Sultana, Tsee Foong Loh, Jan Hau Lee
OBJECTIVES: The Pediatric Acute Lung Injury Consensus Conference developed a pediatric specific definition for acute respiratory distress syndrome (PARDS). In this definition, severity of lung disease is stratified into mild, moderate, and severe groups. We aim to describe the epidemiology of patients with PARDS across Asia and evaluate whether the Pediatric Acute Lung Injury Consensus Conference risk stratification accurately predicts outcome in PARDS. DESIGN: A multicenter, retrospective, descriptive cohort study...
July 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28746195/the-immediate-effect-of-facial-candling-on-inflammatory-mediators-substance-p-symptoms-severity-and-quality-of-life-in-allergic-rhinitis-patients-study-protocol-for-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Nor Faizatul Fatikah Ismail, Chin Fen Neoh, Siong Meng Lim, Amir Heberd Abdullah, Mohd Fahmi Mastuki, Kalavathy Ramasamy, Nazli Zainuddin, Lokman Saim, Long Chiau Ming
INTRODUCTION: Asian countries have a variety of ethnic groups and culture that provide their own traditional treatment in health care. Facial candling appears to be one of the popular traditional treatments in Southeast Asian. The complementary medicine practitioners promote that the facial candling treatment would help in reducing the symptoms of allergic rhinitis and other problems related to sinus. Due to the lack of evidence available, the effectiveness of this treatment method and its mechanism, however, remains unknown...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745662/-atropine-use-for-progressive-myopia-in-children-and-adolescents
#20
T Yu Verzhanskaya
The worldwide prevalence of myopia varies within the range of 20-50% among the adult population of Europe and the United States reaching 60-90% in Asian countries. Reduction of pediatric myopia rates is an important task of medicine. From many reported conservative methods for stabilization of myopia, those that involve pharmaceutical measures are worth paying attention to. This review covers publications dated 1964 or later that contain the results of atropine use at different concentrations in children and adolescents with a minimum follow-up period of 5 years...
2017: Vestnik Oftalmologii
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