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Endometrial uterine cancer

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https://www.readbyqxmd.com/read/29137235/the-significance-of-post-translational-removal-of-%C3%AE-dg-n-in-early-stage-endometrial-cancer-development
#1
Sophea Heng, Jemma Evans, Lois A Salamonsen, Tom W Jobling, Guiying Nie
Endometrial cancer is one of the most common gynecological malignancies affecting post-menopausal women, yet the underlying mechanisms are not well understood. Dystroglycan (DG) is a large glycoprotein, consisting of α- and β-subunits that are non-covalently associated with each other. Modifications to α-DG have been linked to a variety of cancers, where the N-terminus of α-DG (α-DG-N) is post-translationally removed by a furin-like enzyme. However, the functional significance of α-DG-N removal is unknown...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133142/dedifferentiated-endometrial-carcinomas-with-neuroendocrine-features-a-clinicopathologic-immunohistochemical-and-molecular-genetic-study
#2
Iñigo Espinosa, Antonio De Leo, Emanuela D'Angelo, Juan M Rosa-Rosa, Marina Corominas, Alan Gonzalez, José Palacios, Jaime Prat
Undifferentiated endometrial carcinoma is an aggressive type of uterine cancer which is occasionally associated with a low-grade endometrioid carcinoma component. This combination is referred to as "dedifferentiated endometrioid endometrial carcinoma." Neuroendocrine expression may occur in undifferentiated endometrial carcinoma but its significance in dedifferentiated endometrial carcinomas is unknown. To gain insight into the pathogenesis of these tumors we have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, b-catenin, SMARCB1, synaptophysin, chromogranin A, and CD56) and mutational status (PTEN, KRAS, PIK3CA, TP53 and POLE) of 4 dedifferentiated endometrial carcinomas with strong and diffuse neuroendocrine expression...
November 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/29130934/recurrent-ubiquitin-b-silencing-in-gynecological-cancers-establishes-dependence-on-ubiquitin-c
#3
Alexia T Kedves, Scott Gleim, Xiaoyou Liang, Dennis M Bonal, Frederic Sigoillot, Fred Harbinski, Sneha Sanghavi, Christina Benander, Elizabeth George, Prafulla C Gokhale, Quang-De Nguyen, Paul T Kirschmeier, Robert J Distel, Jeremy Jenkins, Michael S Goldberg, William C Forrester
Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers. Silencing of UBB reduces cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene. UBB is repressed in approximately 30% of high-grade serous ovarian cancer (HGSOC) patients and is a recurrent lesion in uterine carcinosarcoma and endometrial carcinoma...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29127647/o-glcnacylation-in-women-s-cancers-breast-endometrial-and-ovarian
#4
REVIEW
Gloria M Trinca, Christy R Hagan
O-GlcNAcylation is emerging as a critical regulatory post-translational modification, impacting proteins that regulate cell division, apoptosis, metabolism, cell signaling, and transcription. O-GlcNAc also affects biological homeostasis by integrating information coming from the environment, such as nutrient conditions and extracellular stimuli, with cellular response. Aberrant O-GlcNAc modulation has been linked to metabolic and neurodegenerative diseases, as well as cancers. While many studies have highlighted the significance of O-GlcNAc in cancer, a specific function for O-GlcNAc during tumorigenesis remains unclear and seems to differ according to cancer type...
November 10, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29118475/histological-follow-up-in-patients-with-atypical-glandular-cells-on-pap-smears
#5
Gokhan Boyraz, Derman Basaran, Mehmet Coskun Salman, Akbar Ibrahimov, Sevgen Onder, Orkun Akman, Nejat Ozgul, Kunter Yuce
Context: Atypical glandular cells (AGCs) result in the Papanicolaou (Pap) smear may be associated with significant genital and nongenital neoplastic processes. Aims: To evaluate the underlying histopathology in women who had AGCs on Pap smears. Settings and Design: Retrospective cross-sectional study. Patients and Methods: Clinicopathological data of patients who had AGC on Pap smears and underwent histological workup between January 2004 and December 2014 were retrieved from the computerized database of a tertiary care center...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29113150/aberrant-chromatin-remodeling-in-gynecological-cancer
#6
Ryuichiro Okawa, Kouji Banno, Miho Iida, Megumi Yanokura, Takashi Takeda, Moito Iijima, Haruko Kunitomi-Irie, Kanako Nakamura, Masataka Adachi, Kiyoko Umene, Yuya Nogami, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki
Epigenetic regulatory mechanisms are a current focus in studies investigating cancer. Chromatin remodeling alters chromatin structure and regulates gene expression, and aberrant chromatin remodeling is involved in carcinogenesis. AT-rich interactive domain-containing protein 1A (ARID1A) and SWItch/sucrose non-fermentable-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 are remodeling factors that are mutated in numerous types of cancer. In gynecological cancer, ARID1A mutations have been identified in 46-57% of clear cell carcinoma and 30% of endometrioid carcinoma...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29109863/pattern-of-gynaecological-malignancies-in-south-western-region-of-pakistan-an-overview-of-12-years
#7
Hina Manzoor, Hamida Naheed, Khushnaseeb Ahmad, Shehla Iftikhar, Muhammad Asif, Jamila Shuja, Neelam Sultan, Irfan Ali, Syed Inayatullah, Yasir Hayat Khan
Gynaecological malignancies contribute significantly to cancer burden and have a higher rate of mortality and morbidity. The aim of this retrospective study was to determine the pattern of gynaecological malignancies identified between January, 2000 and December, 2011, at the Centre for Nuclear Medicine and Radiotherapy (CENAR). At CENAR 5,072 female patients were registered with different malignancies, of which 632 cases were gynaecological malignancies. Ovarian cancer (47%) was the most common gynaecological malignancy, followed by cervical cancer (29%), uterine cancer (14%), vulvar and vaginal cancer (6%), and gestational trophoblastic neoplasm (4%)...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29101714/changes-in-healthcare-spending-after-diagnosis-of-comorbidities-among-endometriosis-patients-a-difference-in-differences-analysis
#8
Andrew J Epstein, Ahmed M Soliman, Matthew Davis, Scott J Johnson, Michael C Snabes, Eric S Surrey
INTRODUCTION: We sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities. METHODS: Women aged 18-49 years with endometriosis (N = 180,278) were extracted from 2006-2015 de-identified Clinformatics(®) DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Controls were identified on the basis of having no comorbidity diagnosis and were matched 1:1 to comorbidity patients on demographics and baseline spending...
November 3, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29100604/-clinical-trials-and-perspectives-of-radiotherapy-for-uterine-endometrial-cancers
#9
REVIEW
Cyrus Chargari, Pierre Maroun, Ioana Lazarescu, Christine Haie-Meder
The adjuvant management of uterine endometrial cancer has been studied in many randomized trials, leading to define postoperative therapeutic indications, depending on the risk factors for relapse, and on the expected benefit in terms of locoregional control and survival. The potential toxicity of treatments should be also considered. We review the available literature that yielded to guidelines that were recently published, on behalf of European societies, and we highlight the perspectives on ongoing studies, aimed at better defining the place and type of adjuvant treatment...
October 31, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29096350/endometrioid-adenocarcinoma-originating-simultaneously-from-endometrium-sites-of-adenomyosis-and-ovarian-endometriosis-a-case-report-and-review-of-our-cancer-database
#10
Lena Tashima, Kensuke Hori, Hitomi Ono, Teruaki Nagano, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Although adenomyosis is a common disease, it is a relatively rare site for cancer origin. On the other hand, chocolate cysts have the potential to develop into cancer. We report a case of endometrioid adenocarcinoma occurred at three sites simultaneously; uterine endometrium, adenomyosis and ovarian endometriosis. PRESENTATION OF CASE: A 51-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy after a diagnosis of corpus cancer (endometrioid adenocarcinoma, G1) stage IA...
October 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29093822/ezh2-inhibition-in-arid1a-mutated-clear-cell-and-endometrioid-ovarian-and-endometrioid-endometrial-cancers
#11
REVIEW
Jill K Alldredge, Ramez N Eskander
Clear cell carcinoma and endometrioid adenocarcinoma are histologic subtypes of ovarian and uterine cancer that demonstrate unique clinical behavior but share common underlying genomic aberrations and oncogenic pathways. ARID1A mutations are more frequently identified in these tumors, in comparison to other gynecologic histologies, and loss of ARID1A tumor suppressor function is thought to be an essential component of carcinogenic transformation. Several therapeutic targets in ARID1A mutated cancers are in development, including EZH2 inhibitors...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29077194/metformin-for-endometrial-hyperplasia
#12
REVIEW
Naomi S Clement, Thomas Rw Oliver, Hunain Shiwani, Juliane Rf Sanner, Caroline A Mulvaney, William Atiomo
BACKGROUND: Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial cancer if left untreated. Endometrial hyperplasia occurs more commonly than endometrial cancer. Progesterone tablets currently used to treat women with endometrial hyperplasia are associated with adverse effects in up to 84% of women...
October 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29075673/healthy-lifestyle-intervention-for-african-american-uterine-cancer-survivors-study-protocol
#13
Jessica Lynn Stewart, Gina B Besenyi, Lovoria B Williams, Victoria Burt, Judith C Anglin, Sharad A Ghamande, Steven Scott Coughlin
BACKGROUND: Cancer of the uterine corpus is the most common gynecologic malignancy and the fourth most common cancer in U.S. women. There is a racial disparity in the survival from endometrial cancer and this may be addressed by culturally-tailored lifestyle interventions to help African American (AA) endometrial cancer survivors lose weight or maintain a healthy weight. OBJECTIVE: The overall purpose of this pilot study is to develop and evaluate a culturally-tailored lifestyle intervention to help AA uterine cancer survivors reduce their risk of cancer recurrence and improve their quality of life through healthy eating, physical activity, and weight management...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29067084/value-of-he4-combined-with-cancer-antigen-125-in-the-diagnosis-of-endometrial-cancer
#14
Chunhua Dong, Ping Liu, Chao Li
OBJECTIVE: To investigate the clinical significance of human epididymal secretory protein E4 (HE4) in combination with cancer antigen 125 (CA125) in the diagnosis of endometrial cancer. METHODS: One hundred and fifty patients with endometrial cancer who were admitted to Binzhou People's Hospital, Shandong, China, between June 2013 and July 2014, were enrolled and set as an endometrial cancer group; another one hundred patients with benign uterine diseases and one hundred healthy females were also enrolled...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29057431/is-routine-performance-of-the-uterine-cervix-canal-curettage-prior-to-the-curettage-of-the-uterine-cavity-justified
#15
Szymon Piątek, Jacek Lipa, Monika Górska, Katarzyna Malecha, Grzegorz Panek, Mirosław Wielgoś
OBJECTIVES: Endocervical curettage (ECC) together with the dilatation and curettage of the uterine cavity (D & C) is routinely performed in everyday clinical practice. The aim of this study is to assess the rationale of the performance of ECC prior to D & C in indications other than abnormal uterine bleeding (AUB). MATERIAL AND METHODS: Case histories of 736 patients after ECC performed in the 1st Department of Obstetrics and Gynaecology, Medical University of Warsaw, were analyzed retrospectively, the indications for the procedure - age, menopausal status, parity, procedure operator's experience - as well as the result of the histopathology examination were taken into account...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29057034/oxidative-stress-and-endometriosis-a-systematic-review-of-the-literature
#16
REVIEW
Gennaro Scutiero, Piergiorgio Iannone, Giulia Bernardi, Gloria Bonaccorsi, Savino Spadaro, Carlo Alberto Volta, Pantaleo Greco, Luigi Nappi
Endometriosis is one of the most common gynaecologic diseases in women of reproductive age. It is characterized by the presence of endometrial tissue outside the uterine cavity. The women affected suffer from pelvic pain and infertility. The complex etiology is still unclear and it is based on three main theories: retrograde menstruation, coelomic metaplasia, and induction theory. Genetics and epigenetics also play a role in the development of endometriosis. Recent studies have put the attention on the role of oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, which may be implicated in the pathophysiology of endometriosis causing a general inflammatory response in the peritoneal cavity...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29056441/use-of-a-novel-sentinel-lymph-node-mapping-algorithm-reduces-the-need-for-pelvic-lymphadenectomy-in-low-grade-endometrial-cancer
#17
Edward Tanner, Allison Puechl, Kimberly Levinson, Laura J Havrilesky, Abdulrahman Sinno, Angeles Alvarez Secord, Amanda N Fader, Paula S Lee
OBJECTIVES: To evaluate the capability of a novel sentinel lymph node (SLN) mapping algorithm to reduce the need for pelvic lymphadenectomy (PLND) in patients with low-grade (G1-2) endometrial cancer (LGEC). METHODS: Patients with LGEC underwent evaluation according to a novel lymphatic assessment algorithm during hysterectomy with SLN biopsy at two academic gynecologic oncology programs. Side-specific PLND was only performed if ipsilateral SLN mapping failed and high-risk uterine features were identified on frozen section (FS)...
October 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29045681/international-patterns-and-trends-in-endometrial-cancer-incidence-1978-2013
#18
Joannie Lortet-Tieulent, Jacques Ferlay, Freddie Bray, Ahmedin Jemal
Background: Cancers of the corpus uteri-primarily of the endometrium-rank as the sixth most common neoplasm in women worldwide. Analyses of the global patterns and trends of uterine cancer rates are needed in view of the ongoing obesity epidemic, a major risk factor for the disease. Methods: Data on endometrial cancer (ICD-10 C54) incidence from population-based cancer registries in 43 populations, published in CI5plus or by registries, were extracted for 1978 to 2013...
October 16, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#19
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040191/incidence-patterns-and-survival-of-gynecological-sarcoma-in-germany-analysis-of-population-based-cancer-registry-data-on-1066-women
#20
Klaus Pietzner, Nina Buttmann-Schweiger, Jalid Sehouli, Klaus Kraywinkel
OBJECTIVE: Sarcomas of the female genital tract are rare tumors. They are described to be associated with a poor prognosis when compared with gynecogical carcinoma. The aim of this study was to report incidence patterns and survival rates for gynecological sarcoma (GS) in Germany. METHODS/MATERIALS: Clinical data and survival rates for patients with GS diagnosed in Germany between 2009 and 2013 were extracted from the German national center for population-based cancer registry data...
October 17, 2017: International Journal of Gynecological Cancer
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