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Endometrial uterine cancer

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https://www.readbyqxmd.com/read/28533155/indications-and-techniques-for-robotic-pelvic-and-para-aortic-lymphadenectomy-with-sentinel-lymph-node-mapping-in-gynecologic-oncology
#1
REVIEW
Ketura Preya A Wisner, Sarfraz Ahmad, Robert W Holloway
Robotic-assisted laparoscopic surgery is the most common approach for the treatment of early-stage endometrial and cervical cancers in the US. Surgical staging requires pelvic and often aortic lymphadenectomy, depending on the primary tumor characteristics. Pelvic and aortic lymphadenectomy procedures may also be indicated for debulking of larger metastases to improve disease control. The infra-renal basin is an important anatomic site of metastasis from pelvic tumors, and robotic dissection techniques for this site have been described...
April 24, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28525912/clinicopathologic-characteristics-of-endometrial-cancer-in-lynch-syndrome-a-french-multicenter-study
#2
Léa Rossi, Marie-Aude Le Frere-Belda, Pierre Laurent-Puig, Bruno Buecher, Antoine De Pauw, Dominique Stoppa-Lyonnet, Geoffroy Canlorbe, Olivier Caron, Bruno Borghese, Chrystelle Colas, Hélène Delhomelle, Nathalie Chabbert-Buffet, Sophie Grandjouan, Fabrice Lecuru, Anne-Sophie Bats
BACKGROUND: Limited data exist on Lynch syndrome (LS)-related endometrial cancer (EC) features. Amsterdam criteria II, commonly used, have poor sensitivity for detection of LS, which is underdiagnosed. AIM: The aim of this study was to describe the clinical and pathological features of LS-related EC among mutation-proven patients. METHODS: We conducted a retrospective study from 1977 to 2013 in 5 hospitals. The inclusion criteria were patients who had a primary EC associated to LS proven by a germline mutation...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28525495/national-cancer-database-report-of-lymphadenectomy-trends-in-endometrial-cancer
#3
James Cripe, Elizabeth Handorf, Jennifer Brown, Angela Jain, Stephen Rubin, Gina Mantia-Smaldone
OBJECTIVES: Lymph node involvement has a significant impact on prognosis that may direct adjuvant therapy. The role of routine lymph node staging (LNS) is controversial given conflicting results in multiple studies. Our aims are to describe treatment patterns of LNS, identify factors impacting LNS, and quantify the contemporary trends. METHODS/MATERIALS: The National Cancer Data Base was queried for patients undergoing hysterectomy for endometrioid and serous uterine carcinomas from 2003 to 2012...
May 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28520777/network-based-stratification-of-major-cancers-by-integrating-somatic-mutation-and-gene-expression-data
#4
Zongzhen He, Junying Zhang, Xiguo Yuan, Zhaowen Liu, Baobao Liu, Shouheng Tuo, Yajun Liu
The stratification of cancer into subtypes that are significantly associated with clinical outcomes is beneficial for targeted prognosis and treatment. In this study, we integrated somatic mutation and gene expression data to identify clusters of patients. In contrast to previous studies, we constructed cancer-type-specific significant co-expression networks (SCNs) rather than using a fixed gene network across all cancers, such as the network-based stratification (NBS) method, which ignores cancer heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/28509323/triple-negative-endometrial-cancer
#5
Michał Bulsa, Elżbieta Urasińska
Endometrial cancer (EC) is the most common malignancy of the female genital tract in the developed countries. In Poland, EC incidence increased from 3.496 to 5.251 between 2000 and 2011, with 5.251 new cases were diagnosed in 2011 alone, and this upward trend is expected to continue. There are two types of endometrial cancer: estrogen- related type I (approximately 80% of the cases) and unrelated to estrogen type II. Type I includes adenocarcinomas which grow slowly, have better prognosis, superficially infiltrate the myometrium, originate from endometrial hyperplasia without atypia, and occur before and after menopause...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28498258/evaluation-and-selection-of-quality-indicators-for-the-management-of-endometrial-cancer
#6
Laure Chenoz, Juliette Phelippeau, Emmanuel Barranger, Nicolas Bourdel, Jean Luc Brun, Elisabeth Chereau, Pierre Collinet, Charles Coutant, Emile Darai, Xavier Deffieux, Tristan Gautier, François Golfier, Cyrille Huchon, Lobna Ouldamer, Roman Rouzier, Martin Koskas
OBJECTIVE: The aim of this study was to evaluate 36 quality indicators (QIs) for monitoring the quality of care of uterine cancer to be implemented in the EFFECT (effectiveness of endometrial cancer treatment) project. METHODS: The 36 QIs were evaluated in the first 10 patients diagnosed with endometrial cancer and managed in 14 French hospitals in 2011. To assess the status of each QI, a questionnaire detailing the 36 QIs was sent to each hospital, and the information was cross-checked with information from the multidisciplinary staff meeting, surgical reports, and pathological reports...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498249/clinicopathological-characteristics-and-prognostic-factors-of-synchronous-endometrial-and-ovarian-cancers-a-single-institute-review-of-43-cases
#7
Vandana Jain, Rupinder Sekhon, Sunil Pasricha, Shveta Giri, Kanika Batra Modi, Eliza Shrestha, Dharma Ram, Sudhir Rawal
OBJECTIVES: The objectives of our study were to demonstrate the clinicopathological characteristics and determine the prognostic factors for women with synchronous primary cancers of the endometrium and ovary. METHODS: A retrospective analysis of 43 pathologically proven cases of synchronous primary endometrial and ovarian cancers diagnosed between January 2005 and December 2015 was carried out. Patients with uterine sarcomas, carcinosarcomas, borderline tumors, and nonepithelial tumors of the ovary and patients who received neoadjuvant chemotherapy were excluded from the study...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28494767/intestinal-differentiated-mucinous-adenocarcinoma-of-the-endometrium-with-sporadic-msi-high-status-a-case-report
#8
Mafalda Trippel, Sara Imboden, Andrea Papadia, Michael D Mueller, Nando Mertineit, Kirsi Härmä, Alina Nicolae, Erik Vassella, Tilman T Rau
BACKGROUND: Intestinal differentiation of primary mucinous adenocarcinoma of the uterine corpus is exceedingly rare in comparison to the approximately 25% rate in endocervical and ovarian mucinous carcinoma. Additionally, little is known about the related genetic and epigenetic alterations, even though large-scale molecular characterisation of the different types of endometrial cancer took place in the TCGA project along the entities defined by the recent WHO classification. CASE PRESENTATION: We present a 62-year-old patient harbouring a primary mucinous carcinoma of the uterine corpus with a morphological resemblance to mucinous colorectal adenocarcinoma...
May 12, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28488577/the-significance-of-post-translational-removal-of-%C3%AE-dg-n-in-early-stage-endometrial-cancer-development
#9
Sophea Heng, Jemma Evans, Lois A Salamonsen, Tom W Jobling, Guiying Nie
Endometrial cancer is one of the most common gynecological malignancies affecting post-menopausal women, yet the underlying mechanisms are not well understood. Dystroglycan (DG) is a large glycoprotein, consisting of α- and β-subunits that are non-covalently associated with each other. Modifications to α-DG have been linked to a variety of cancers, where the N-terminus of α-DG (α-DG-N) is post-translationally removed by a furin-like enzyme. However, the functional significance of α-DG-N removal is unknown...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28481808/intraluminal-uterine-hypodensity-in-ct-scans-of-postmenopausal-women-recommendations-for-interpretation
#10
Michal Marianne Amitai, Mohamad Yassin, Nayrouz Kanana, Sara Apter, Noa Rozendorn, Eli Konen, Eyal Klang
OBJECTIVE: This study aims to investigate the association between intraluminal uterine hypodensity and uterine malignancy and establish thresholds that would minimize routine gynecological evaluation. METHODS: Two groups were recruited retrospectively: cancer group, which comprised 32 sequential endometrial cancer patients, and postmenopausal group, which comprised 63 women, with no known gynecologic malignancy.Two radiologists independently measured hypodensity, transversely in the axial plane and anterioposteriorly in the sagittal plane...
May 6, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28451168/mechanistic-study-of-cbt-cys-click-reaction-and-its-application-for-identifying-bioactive-n-terminal-cysteine-peptides-in-amniotic-fluid
#11
Zhen Zheng, Peiyao Chen, Gongyu Li, Yunxia Zhu, Zhonghua Shi, Yufeng Luo, Chun Zhao, Ziyi Fu, Xianwei Cui, Chenbo Ji, Fuqiang Wang, Guangming Huang, Gaolin Liang
CBT-Cys click condensation reaction has a high second-order reaction rate constant and has found wide applicability in recent years. However, its reaction mechanism has not been experimentally validated and its application for identifying bioactive N-terminal Cys peptides in real clinical samples has not been reported. Herein, firstly, by employing induced nanoelectrospray ionization-mass spectrometry (InESI-MS) and a home-built micro-reactor, we successfully intercepted and structurally characterized the crucial intermediate in this click reaction for the first time...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#12
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28439599/agreement-of-histopathological-findings-of-uterine-curettage-and-hysterectomy-specimens-in-women-with-abnormal-uterine-bleeding
#13
Sanam Moradan, Raheb Ghorbani, Azita Lotfi
To examined the diagnostic value of  dilatation and curettage (D and C) in patients with abnormal uterine bleeding (AUB) by conducting a histopathological examination of endometrial tissues by D and C and hysterectomy. Methods: In this retrospective study, the medical records of 163 women who had been hospitalized  in the Obstetrics and Gynecology Ward, Amir-al-Momenin Hospital, Semnan, Iran between 2010 and 2015 for diagnostic curettage due to  AUB and who had undergone hysterectomy were investigated. The patients' characteristics and histopathologic results of curettage and hysterectomy were extracted, and sensitivity and specificity and positive and negative predictive values of curettage were calculated...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28439056/-calcium-and-bone-metabolism-across-women-s-life-stages-treatment-for-the-malignant-tumors-in-women-and-bone-calcium-metabolism
#14
Noriko Kobayashi
In the malignant tumors in women, uterine cervical cancer, endometrial cancer, ovarian cancer, and breast cancer are representative diseases. The cancer treatment is classified roughly into an operation, medical treatment, and radiation therapy and has an extremely big influence on ovarian function. With the improvement in survival of cancer patients, the importance of the health care for the cancer survivors increases. It is necessary to prevent the onset of the osteoporotic fractures to maintain QOL. This paper describes the action that the malignant tumors of the women affect bone metabolism mainly from the viewpoint of ovarian function...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28437632/bgcs-uterine-cancer-guidelines-recommendations-for-practice
#15
REVIEW
Sudha Sundar, Janos Balega, Emma Crosbie, Alasdair Drake, Richard Edmondson, Christina Fotopoulou, Ioannis Gallos, Raji Ganesan, Janesh Gupta, Nick Johnson, Sarah Kitson, Michelle Mackintosh, Pierre Martin-Hirsch, Tracie Miles, Saeed Rafii, Nick Reed, Phil Rolland, Kavita Singh, Vanitha Sivalingam, Axel Walther
The British Gynaecological Cancer Society has issued the first Endometrial (Uterine) Cancer guidelines as recommendation for practice for the UK.
April 13, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28406780/dysphagia-an-unusual-presentation-of-metastatic-uterine-cervical-carcinoma
#16
Anam Hameed, Alexander A Dekovich, Phillip J Lum, Mehnaz A Shafi
Worldwide, cervical cancer is the third most common cancer among women and the fourth leading cause of death from cancer. The most common sites of metastasis are the pelvic lymph nodes, vagina, and the pelvic sidewalls. Distant metastases are uncommon but can involve the bone, lung, and liver. Characteristics associated with increased rate of distant metastasis include bulky tumor, endometrial extension, lymph node involvement, and advanced disease. We report the case of a woman with stage II cervical carcinoma, who presented with dysphagia due to cervical cancer metastases to the mediastinum...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28405900/evaluation-of-pre-surgical-models-for-uterine-surgery-by-use-of-three-dimensional-printing-and-mold-casting
#17
Sayed Ahmad Zikri Bin Sayed Aluwee, Xiangrong Zhou, Hiroki Kato, Hiroshi Makino, Chisako Muramatsu, Takeshi Hara, Masayuki Matsuo, Hiroshi Fujita
We propose an approach to supporting pre-surgical planning for the uterus by integrating medical image analysis and physical model generation based on 3D printing. With our method, we first segment the patient-specific anatomy and lesions of the uterus on MR images; then, we create a 3D physical model, an exact replica of the patient's uterus in terms of size and softness, with transparency for easy observation of the internal structures of the uterus. In our experiments, we created pre-surgical models of hysterectomy for five patients who had been diagnosed to have uterine endometrial cancer...
April 12, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28400352/frequency-of-uterine-sarcomas-in-patients-admitted-for-uterine-fibroids-surgery
#18
Liselotte Mettler, Nicolai Maass, Khulkar Abdusattarova, Astrid Dempfle, Ibrakhim Alkatout
OBJECTIVE: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at the single-center university hospital. MATERIAL AND METHODS: This was a retrospective single-center study; the records of all 2,275 patients with uterine fibroids and uterine sarcomas from 2003 to 2015 were reviewed. Descriptive statistics were used to analyze demographic and clinical characteristics. To calculate confidence intervals (CIs), the exact Clopper-Pearson method was applied...
February 7, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28399028/pathologic-and-treatment-outcomes-among-a-geriatric-population-of-endometrial-cancer-patients-an-nrg-oncology-gynecologic-oncology-group-ancillary-data-analysis-of-lap2
#19
Erin A Bishop, James J Java, Kathleen N Moore, Joan L Walker
OBJECTIVES: Elderly endometrial cancer patients have worse disease-specific survival than their younger counterparts, but the cause for this discrepancy is unknown. The goal of this analysis is to compare outcomes by age in a fully staged elderly endometrial cancer population. METHODS/MATERIALS: This is an analysis of patients on Gynecologic Oncology Group Study (GOG) LAP2, which included clinically early stage endometrial cancer patients randomized to laparotomy versus laparoscopy for surgical staging...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28394884/long-term-hormone-responsive-organoid-cultures-of-human-endometrium-in-a-chemically-defined-medium
#20
Margherita Y Turco, Lucy Gardner, Jasmine Hughes, Tereza Cindrova-Davies, Maria J Gomez, Lydia Farrell, Michael Hollinshead, Steven G E Marsh, Jan J Brosens, Hilary O Critchley, Benjamin D Simons, Myriam Hemberger, Bon-Kyoung Koo, Ashley Moffett, Graham J Burton
In humans, the endometrium, the uterine mucosal lining, undergoes dynamic changes throughout the menstrual cycle and pregnancy. Despite the importance of the endometrium as the site of implantation and nutritional support for the conceptus, there are no long-term culture systems that recapitulate endometrial function in vitro. We adapted conditions used to establish human adult stem-cell-derived organoid cultures to generate three-dimensional cultures of normal and decidualized human endometrium. These organoids expand long-term, are genetically stable and differentiate following treatment with reproductive hormones...
May 2017: Nature Cell Biology
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