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Endometrial uterine cancer

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https://www.readbyqxmd.com/read/29780815/endometriosis-malignant-transformation-epigenetics-as-a-probable-mechanism-in-ovarian-tumorigenesis
#1
REVIEW
Jiaxing He, Weiqin Chang, Chunyang Feng, Manhua Cui, Tianmin Xu
Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of various mechanisms of development...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29779939/endometrial-carcinoma-in-a-single-horn-of-a-bicornuate-uterus-a-case-report
#2
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
May 17, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29777346/cytological-assessment-of-endometrial-washings-obtained-with-karman-cannula-using-a-liquid-based-preparation-method-for-the-detection-of-endometrial-pathologies
#3
Cetin Kilicci, Ebru Çogendez, Pınar Kumru, Evrim Bostanci Ergen, Nermin Koc, Cigdem Abide Yayla
OBJECTIVE: The aim of this study was to evaluate the diagnostic efficacy and utility of liquid-based cytology in ThinPrep (Cytyc Corporation, Boxborough, MA) for endometrial lesions in patients presenting with abnormal uterine bleeding. MATERIALS AND METHODS: Two hundred and thirteen women scheduled for dilatation and curettage because of abnormal uterine bleeding were enrolled in the study. After providing informed consent, all the women proceeded sequentially to endometrial cytology and then dilatation and curettage...
May 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29775456/maternal-obesogenic-diet-induces-endometrial-hyperplasia-an-early-hallmark-of-endometrial-cancer-in-a-diethylstilbestrol-mouse-model
#4
Theresa O Owuor, Michaela Reid, Lauren Reschke, Ian Hagemann, Suellen Greco, Zeel Modi, Kelle H Moley
Thirty-eight percent of US adult women are obese, meaning that more children are now born of overweight and obese mothers, leading to an increase in predisposition to several adult onset diseases. To explore this phenomenon, we developed a maternal obesity animal model by feeding mice a diet composed of high fat/ high sugar (HF/HS) and assessed both maternal diet and offspring diet on the development of endometrial cancer (ECa). We show that maternal diet by itself did not lead to ECa initiation in wildtype offspring of the C57Bl/6J mouse strain...
2018: PloS One
https://www.readbyqxmd.com/read/29773071/endometrial-cancer-how-many-patients-could-benefit-from-sentinel-lymph-node-dissection
#5
Sarah Brugger, Moritz Hamann, Marc Mosner, Michaela Beer, Michael Braun, Martin Pölcher
BACKGROUND: Sentinel lymph node dissection (SLND) may reduce morbidity in patients with endometrial cancer. The objective of this study is to estimate how many systematic lymph node dissections (LND) can be spared with an implementation of a SLN-procedure. METHODS: Retrospective, single-center study, SLND according to NCCN-Guidelines. RESULTS: In 109 patients of 154 consecutive patients, SLND was performed. The detection rate was 61% on both sides and 86% on at least one side...
May 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29754696/follicle-stimulating-hormone-receptor-protein-is-expressed-in-ovine-uterus-during-the-estrous-cycle-and-utero-placenta-during-early-pregnancy-an-immunohistochemical-study
#6
Anna T Grazul-Bilska, Arshi Reyaz, Veselina Valkov, Sheri T Dorsam, Dale A Redmer
Follicle stimulating hormone (FSH) is a well characterized gonadotropin that controls primarily development and functions of ovarian follicles in mammalian species. FSH binds to a specific G protein-coupled receptor (FSHR) belonging to the glycoprotein hormone receptor family that plays an essential role in reproduction. Although the primary location of FSHR is in the gonads (mainly in ovarian follicles), FSHR protein and/or mRNA have also been detected in extragonadal female reproductive tissues including embryo, placenta, endometrium, cervix, ovarian cancer tissues, and/or endometriotic lesions in several species...
May 11, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29752277/the-highly-metastatic-nature-of-uterine-cervical-endometrial-cancer-displaying-tumor-related-leukocytosis-clinical-and-preclinical-investigations
#7
Tomoyuki Sasano, Seiji Mabuchi, Katsumi Kozasa, Hiromasa Kuroda, Mahiru Kawano, Ryoko Takahashi, Naoko Komura, Eriko Yokoi, Yuri Matsumoto, Kae Hashimoto, Kenjiro Sawada, Eiichi Morii, Tadashi Kimura
PURPOSE: The aim of this study was to investigate the metastatic potential of uterine cervical and endometrial cancer displaying tumor-related leukocytosis (TRL). EXPERIMENTAL DESIGN: Clinical data on uterine cervical (N=732) and endometrial cancer (N=900) were collected, and the metastatic potential of TRL-positive cancer was evaluated in univariate and multivariate analyses. Tumor and blood samples obtained from cervical cancer patients, cervical cancer cell lines, and a mouse model of cervical cancer were employed to examine the mechanisms underlying the highly metastatic nature of TRL-positive cancer, focusing on tumor-derived granulocyte-colony stimulating factor (G-CSF) and the myeloid-derived suppressor cells (MDSC)-mediated premetastatic niche...
May 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29736565/the-flavonoid-apigenin-is-a-progesterone-receptor-modulator-with-in-vivo-activity-in-the-uterus
#8
Matthew Dean, Julia Austin, Ren Jinhong, Michael E Johnson, Daniel D Lantvit, Joanna E Burdette
Apigenin is a flavonoid with well-documented anti-cancer properties; however, its mechanisms of action are still unclear. We previously identified apigenin as a potential phytoprogestin, a natural product with a chemical scaffold that interacts with the progesterone receptor (PR). Our objective was to characterize the ability of apigenin to interact with PR through molecular docking studies, in vitro activity assays, and the ability of apigenin to elicit progestin-like effects in vivo. Molecular docking confirmed that apigenin could interact with PR, though with lower affinity than progesterone due to fewer van der Waals interactions...
May 7, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29716549/lyl1-gene-amplification-predicts-poor-survival-of-patients-with-uterine-corpus-endometrial-carcinoma-analysis-of-the-cancer-genome-atlas-data
#9
Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo
BACKGROUND: Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers. This study was undertaken to determine whether such genetic alterations affect survival outcomes of UCEC. METHODS: In 370 patients with UCEC, we analysed clinicopathologic characteristics and corresponding genomic data from The Cancer Genome Atlas database. Patients were stratified according to LYL1 gene status, grouped as amplification or non-amplification...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29708902/the-case-against-endometrial-ablation-for-treatment-of-heavy-menstrual-bleeding
#10
Michelle Louie, Kelly Wright, Matthew Siedhoff
PURPOSE OF REVIEW: Endometrial ablation is a common treatment for heavy menstrual bleeding, but serious limitations and long-term complications exist. Our purpose is to summarize the use of endometrial ablation devices, potential short-term and long-term complications, cost effectiveness, and quality of life in relation to alternative treatments. RECENT FINDINGS: There is insufficient evidence to strongly recommend one endometrial ablation device over another. Providers should consider and discuss with their patients, complications including risk of future pregnancy, endometrial cancer, and hysterectomy for continued bleeding or pain...
April 27, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29700276/endometrial-metastasis-from-ductal-breast-carcinoma-a-case-report-with-literature-review
#11
Maryam Rahmani, Fatemeh Nili, Elnaz Tabibian
BACKGROUND There are few reports of breast cancer cases with uterine metastases; among them, myometrium is more frequently involved than endometrium. The majority of breast cancer metastases to endometrium are lobular type, and there have been only 5 reported cases of ductal type since 1984. Here, we describe a new case of invasive ductal carcinoma with metastases to endometrium and isolated presentation of abnormal uterine bleeding, in addition to reviewing the existing literature on other similar cases. CASE REPORT The patient was a 51-year-old Persian woman with no remarkable past medical or family history of cancer, who presented with a 6-month complaint of menorrhagia to our gynecology clinic...
April 27, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29697491/preoperative-magnetic-resonance-volumetry-in-predicting-myometrial-invasion-lymphovascular-space-invasion-and-tumor-grade-is-it-valuable-in-international-federation-of-gynecology-and-obstetrics-stage-i-endometrial-cancer
#12
Hilal Sahin, Fatma Ceren Sarioglu, Mustafa Bagci, Tugba Karadeniz, Hatice Uluer, Muzaffer Sanci
OBJECTIVE: The aim of this retrospective single-center study was to evaluate the relationship between maximum tumor size, tumor volume, tumor volume ratio (TVR) based on preoperative magnetic resonance (MR) volumetry, and negative histological prognostic parameters (deep myometrial invasion [MI], lymphovascular space invasion, tumor histological grade, and subtype) in International Federation of Gynecology and Obstetrics stage I endometrial cancer. METHODS/MATERIALS: Preoperative pelvic MR imaging studies of 68 women with surgical-pathologic diagnosis of International Federation of Gynecology and Obstetrics stage I endometrial cancer were reviewed for assessment of MR volumetry and qualitative assessment of MI...
May 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29684152/association-between-proportion-of-nuclei-with-high-chromatin-entropy-and-prognosis-in-gynecological-cancers
#13
Birgitte Nielsen, Andreas Kleppe, Tarjei Sveinsgjerd Hveem, Manohar Pradhan, Rolf Anders Syvertsen, John Arne Nesheim, Gunnar Balle Kristensen, Jone Trovik, David James Kerr, Fritz Albregtsen, Håvard Emil Danielsen
Background: Nuclear texture analysis measuring differences in chromatin structure has provided prognostic biomarkers in several cancers. There is a need for improved cell-by-cell chromatin analysis to detect nuclei with highly disorganized chromatin. The purpose of this study was to develop a method for detecting nuclei with high chromatin entropy and to evaluate the association between the presence of such deviating nuclei and prognosis. Methods: A new texture-based biomarker that characterizes each cancer based on the proportion of high-chromatin entropy nuclei (<25% vs ≥25%) was developed on a discovery set of 175 uterine sarcomas...
April 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29682175/alcam-shedding-at-the-invasive-front-of-the-tumor-is-a-marker-of-myometrial-infiltration-and-promotes-invasion-in-endometrioid-endometrial-cancer
#14
Laura Devis, Elena Martinez-Garcia, Cristian P Moiola, Maria Teresa Quiles, Maria Antonia Arbos, Tomita Vasilica Stirbat, Françoise Brochard-Wyart, Ángel García, Lorena Alonso-Alconada, Miguel Abal, Berta Diaz-Feijoo, William Thomas, Sylvie Dufour, Gemma Mancebo, Francesc Alameda, Jaume Reventos, Antonio Gil-Moreno, Eva Colas
Endometrial cancer (EC) is the sixth deadliest cancer in women. The depth of myometrial invasion is one of the most important prognostic factors, being directly associated with tumor recurrence and mortality. In this study, ALCAM, a previously described marker of EC recurrence, was studied by immunohistochemistry at the superficial and the invasive tumor areas from 116 EC patients with different degree of myometrial invasion and related to a set of relevant epithelial and mesenchymal markers. ALCAM expression presented a heterogeneous functionality depending on its localization, it correlated with epithelial markers (E-cadherin/β-catenin) at the superficial area, and with mesenchymal markers at the invasive front (COX-2, SNAIL, ETV5, and MMP-9)...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29673674/association-between-18f-fluorodeoxyglucose-pet-ct-and-histological-grade-of-uterine-endometrial-carcinoma
#15
Hiroaki Takagi, Toshiyuki Sasagawa, Takeo Shibata, Hiroshi Minato, Tomoko Takahashi
OBJECTIVE: The incidence of endometrial adenocarcinoma of the uterine corpus has increased in Japan. This study aimed to clarify the relationships between this type of cancer and various data provided by 18F-fluorodeoxyglucose (FDG) accumulation in positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: The study cohort thus comprised 27 patients with endometrial adenocarcinoma who had undergone PET/CT examinations from April 2008 to March 2015...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29671892/frequent-loss-of-claudin-4-expression-in-dedifferentiated-and-undifferentiated-endometrial-carcinomas
#16
Basile Tessier-Cloutier, Robert A Soslow, Colin J R Stewart, Martin Köbel, Cheng-Han Lee
INTRO: Dedifferentiated/undifferentiated endometrial carcinomas (DDEC/UEC) are aggressive endometrial cancers with frequent genomic inactivation of core components of switch/sucrose non-fermentable (SWI/SNF) complex proteins. Claudin-4, an epithelial intercellular tight junction protein was recently found to be expressed in SWI/SNF-deficient undifferentiated carcinomas but not SWI/SNF-deficient sarcomas. The aim of this study is to examine claudin-4 expression in UEC/DDEC and other high-grade uterine carcinomas...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29670794/coexistence-of-cervical-leiomyosarcoma-and-gastric-type-adenocarcinoma-in-situ-with-extensive-extension-to-the-endometrium-and-fallopian-tube
#17
Ayako Ura, Kanako Ogura, Asumi Sakaguchi, Hiroko Onagi, Daiki Ogishima, Yayoi Sugimori, Kensuke Hamamura, Masaharu Fukunaga, Toshiharu Matsumoto
Cervical leiomyosarcoma is known to be rare from the previous reviews of a large number of malignant cervical tumors. The patient was a 66-year-old woman with irregular vaginal bleeding. She underwent modified radical hysterectomy and bilateral salpingooophorectomy. Histopathologically, we diagnosed the coexistence of uterine cervical leiomyosarcoma and cervical gastric-type adenocarcinoma in situ with endometrial lesions that had continuous and skip patterns and fallopian tubal lesions with a partial lesion...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29665298/establishment-of-a-nine-gene-prognostic-model-for-predicting-overall-survival-of-patients-with-endometrial-carcinoma
#18
Jianchao Ying, Qian Wang, Teng Xu, Jianxin Lyu
Endometrial carcinoma (EC) is the most common malignant tumor of the female genital tract in developed countries. The prognosis of early stage EC is favorable, but a subset faces high risk of cancer progression or recurrence. EC has a poor prognosis upon progression to advanced or metastatic stages. Therefore, our goal is to build a robust prognostic model for predicting overall survival (OS) in EC patients. In this study, 1571 genes were identified as being associated with OS based on genomewide expression profiles using a training dataset...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29664841/three-year-recurrence-free-survival-in-patients-with-a-very-low-risk-of-endometrial-cancer-who-did-not-undergo-lymph-node-dissection-tree-retro-a-korean-multicenter-study
#19
Miseon Kim, ChelHun Choi, Kidong Kim, Myong Cheol Lim, Jeong-Yeol Park, Jin Hwa Hong, Maria Lee, Jiheum Paek, Jungyeob Seoung, Seungho Lee, Taek Sang Lee
OBJECTIVE: Randomized studies have not demonstrated a survival benefit of routine lymph node dissection in early-stage endometrial cancer. Many surgeons nevertheless perform lymph node dissection in all patients with early-stage endometrial cancer. This study aimed to ascertain the survival outcomes of very low-risk endometrial cancer patients (by the Korean Gynecologic Oncology Group [KGOG] criteria) who did not undergo lymph node dissection. MATERIALS AND METHODS: Medical records of 156 consecutive patients who underwent surgical staging without lymph node dissection were collected from 10 institutions...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29662718/is-the-measurement-of-the-size-of-uterine-lesions-with-positron-emission-tomography-consistent-in-pre-and-postmenopausal-periods-in-endometrioid-type-endometrial-cancer
#20
Varol Gülseren, Mustafa Kocaer, Özgü Çelikkol Güngördük, İsa Aykut Özdemir, Muzaffer Sancı, Kemal Güngördük
Objective: We aimed to investigate the correlation of the size and volume of uterine tumors obtained using positron emission tomography/computed tomography (PET/CT) and pathology specimens in patients with endometrioid-type endometrial cancer (EEC) in the premenopausal period, and to compare the results with those of postmenopausal women. In the premenopausal period, the endometrium uses more glucose than in the postmenopausal period. Therefore, the measurement of uterine tumor size using PET/CT in the premenopausal period may normally be different...
March 2018: Turkish Journal of Obstetrics and Gynecology
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