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Coronary Artery Calcium

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https://www.readbyqxmd.com/read/29035431/prognostic-application-of-thoracic-aortic-calcium-scoring-for-adverse-clinical-outcome-risk-in-elderly-patients-with-left-ventricular-hypertrophy
#1
In Jeong Cho, Hyuk Jae Chang, Sang Eun Lee, Chi Young Shim, Geu Ru Hong, Namsik Chung
BACKGROUND AND OBJECTIVES: Left ventricular hypertrophy (LVH) is associated with poor cardiovascular outcomes. Heavy aortic calcification exacerbates arterial stiffness, which consequently heightens left ventricular (LV) afterload. We assessed the usefulness of aortic calcification for predicting adverse cardiovascular outcomes and to determine whether the relationship, if any, differed as a function of LVH. METHODS: The analytic sample was comprised of a total of 487 individuals 65 years of age or older...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29033611/stable-ischemic-heart-disease-in-women-current-perspectives
#2
REVIEW
Fatima Samad, Anushree Agarwal, Zainab Samad
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] >25 kg/m(2)), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29033237/coronary-artery-calcium-guided-prevention-the-time-is-now
#3
EDITORIAL
Todd C Villines
No abstract text is available yet for this article.
October 7, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29030345/runx1-deficiency-protects-against-adverse-cardiac-remodeling-following-myocardial-infarction
#4
Charlotte S McCarroll, Weihong He, Kirsty Foote, Ashley Bradley, Karen McGlynn, Francesca Vidler, Colin Nixon, Katrin Nather, Caroline Fattah, Alexandra H Riddell, Peter Bowman, Elspeth B Elliott, Margaret Bell, Catherine Hawksby, Scott M MacKenzie, Liam J Morrison, Anne Terry, Karen Blyth, Godfrey L Smith, Martin W McBride, Thomas Kubin, Thomas Braun, Stuart A Nicklin, Ewan R Cameron, Christopher M Loughrey
Background -Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure. Consequently, new therapeutic targets are urgently required to achieve this aim. Expression of the Runx1 transcription factor is increased in adult cardiomyocytes following MI; however, the functional role of Runx1 in the heart is unknown...
October 13, 2017: Circulation
https://www.readbyqxmd.com/read/29029196/association-between-coronary-artery-calcification-and-the-hemoglobin-glycation-index-the-kangbuk-samsung-health-study
#5
Eun-Jung Rhee, Jung-Hwan Cho, Hyemi Kwon, Se Eun Park, Cheol-Young Park, Ki-Won Ho, Sung-Woo Park, Won-Young Lee
Context: The hemoglobin glycation index (HGI) is known to be correlated with the risk of cardiovascular disease. Objective: To analyze the association between incident coronary artery calcification (CAC) and the changes in the HGI in participants without diabetes, over 4 years. Design: Setting, and Participants: A retrospective study of two-thousand-and-fifty-two participants in whom the coronary artery calcium score (CACS) was measured repeatedly over 4 years, as part of a health check-up program in Kangbuk Samsung Hospital, and had no CAC at the baseline...
September 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028083/association-between-advanced-oxidation-protein-products-aopp-and-vascular-calcification-in-uremic-patients
#6
L Lin, G-J Zhao, L-L Qin
OBJECTIVE: To investigate the correlation between serum advanced oxidation protein products (AOPP) and vascular calcification in uremic patients. PATIENTS AND METHODS: The general data of included subjects were collected, and the serum AOPP, intact parathyroid hormone (iPTH), creatinine (Cre), Urea, calcium (Ca), phosphorus (P), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterin (LDL-C), hemoglobin (Hb) and albumin (ALB) were detected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29023576/overexpression-of-tissue-nonspecific-alkaline-phosphatase-tnap-in-endothelial-cells-accelerates-coronary-artery-disease-in-a-mouse-model-of-familial-hypercholesterolemia
#7
Filippo Romanelli, AnthonyMarco Corbo, Maryam Salehi, Manisha C Yadav, Soha Salman, David Petrosian, Omid J Rashidbaigi, Jesse Chait, Jes Kuruvilla, Maria Plummer, Ilian Radichev, Kenneth B Margulies, A Martin Gerdes, Anthony B Pinkerton, José Luis Millán, Alexei Y Savinov, Olga V Savinova
OBJECTIVE: Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity in human myocardium. APPROACH AND RESULTS: A vascular pattern of TNAP activity was observed in human non-failing, ischemic, and idiopathic dilated hearts (5 per group); no differences were noted between groups in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29021844/intracoronary-acetylcholine-application-as-a-possible-probe-inducing-j-waves-in-patients-with-early-repolarization-syndrome
#8
REVIEW
Toru Maruyama, Kazumasa Fujita, Kei Irie, Shouhei Moriyama, Mitsuhiro Fukata
Acetylcholine is widely used for a diagnostic provocation test of coronary spasm in patients with vasospastic angina. Acetylcholine usually induces coronary vasodilatation mediated by muscarinic receptor activation, but sometimes it evokes vasoconstriction of coronary arteries where the endothelium is damaged. Early repolarization syndrome is characterized by a J wave observed at the end of the QRS complex in a surface electrocardiogram. The J wave is attributed to the transmural voltage gradient at the early repolarization phase across the ventricular wall, which stems mainly from prominent transient outward current in the epicardium, but not in the endocardium...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29020908/cardiac-society-of-australia-and-new-zealand-position-statement-executive-summary-coronary-artery-calcium-scoring
#9
Christian R Hamilton-Craig, Clara K Chow, John F Younger, V M Jelinek, Jonathan Chan, Gary Yh Liew
Introduction This article summarises the Cardiac Society of Australia and New Zealand position statement on coronary artery calcium (CAC) scoring. CAC scoring is a non-invasive method for quantifying coronary artery calcification using computed tomography. It is a marker of atherosclerotic plaque burden and the strongest independent predictor of future myocardial infarction and mortality. CAC scoring provides incremental risk information beyond traditional risk calculators such as the Framingham Risk Score...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29016370/heavily-calcified-coronary-arteries-advanced-calcium-subtraction-improves-luminal-visualization-and-diagnostic-confidence-in-dual-energy-coronary-computed-tomography-angiography
#10
Domenico De Santis, Kwang Nam Jin, U Joseph Schoepf, Katharine L Grant, Carlo N De Cecco, John W Nance, Thomas J Vogl, Andrea Laghi, Moritz H Albrecht
OBJECTIVES: The aim of this study was to evaluate a prototype dual-energy computed tomography calcium subtraction algorithm and its impact on luminal visualization in patients with heavily calcified coronary arteries. MATERIALS AND METHODS: Twenty-nine patients (62% male; mean age, 64 ± 7 years) who had undergone dual-energy coronary computed tomography angiography were retrospectively included in this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study...
October 9, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28989933/spontaneous-left-main-and-right-coronary-artery-spasm-in-a-patient-with-vasospastic-angina
#11
Analkumar Parikh, Thomas Paul Vacek
Coronary spasm is a well-documented, though rare, condition that can mimic myocardial infarction and is usually found in only a single vessel during an event. We describe the case of a 43-year-old male with past medical history of hypertension, hyperlipidemia, tobacco abuse, and with no known coronary disease. The patient developed chest pain 3 days postadmission for primary diagnosis of psychiatric disorder. The patient had a positive stress study with moderate reversible ischemia in the anterolateral region...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28989085/ferulic-acid-relaxed-rat-aortic-small-mesenteric-and-coronary-arteries-by-blocking-voltage-gated-calcium-channel-and-calcium-desensitization-via-dephosphorylation-of-erk1-2-and-mypt1
#12
Zhong-Yan Zhou, Jia-Qi Xu, Wai-Rong Zhao, Xin-Lin Chen, Yu Jin, Nuo Tang, Jing-Yi Tang
Ferulic acid, a natural ingredient presents in several Chinese Materia Medica such as Radix Angelicae Sinensis, has been identified as an important multifunctional and physiologically active small molecule. However, its pharmacological activity in different blood vessel types and underlying mechanisms are unclear. The present study was to investigate the vascular reactivity and the possible action mechanism of FA on aorta, small mesenteric arteries and coronary arteries isolated from Wistar rats. We found FA dose-dependently relieved the contraction of aorta, small mesenteric arteries and coronary arteries induced by different contractors, U46619, phenylephrine (Phe) and KCl...
October 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28986055/gender-differences-in-the-association-of-epicardial-adipose-tissue-and-coronary-artery-calcification-epicheart-study-eat-and-coronary-calcification-by-gender
#13
Jennifer Mancio, Marilia Pinheiro, Wilson Ferreira, Monica Carvalho, Antonio Barros, Nuno Ferreira, Luis Vouga, Vasco Gama Ribeiro, Adelino Leite-Moreira, Ines Falcao-Pires, Nuno Bettencourt
BACKGROUND: The association of epicardial adipose tissue (EAT) and coronary artery calcification (CAC) seems to differ by gender. However, few studies have controlled for body size, and the ideal method for body size indexing has not been explored. OBJECTIVES: To analyse the effect of gender related-body size and-body fat differences on the association of EAT with CAC. METHODS: This was a prospective cohort of 371 severe aortic stenosis patients (77±8...
September 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28985952/usefulness-of-coronary-artery-calcium-to-predict-heart-failure-with-preserved-ejection-fraction-in-men-versus-women-from-the-multi-ethnic-study-of-atherosclerosis
#14
Kavita Sharma, Mahmoud Al Rifai, Haitham M Ahmed, Zeina Dardari, Michael G Silverman, Joseph Yeboah, Khurram Nasir, Moyses Sklo, Clyde Yancy, Stuart D Russell, Roger S Blumenthal, Michael J Blaha
We studied the association of coronary artery calcium (CAC) and risk of heart failure with preserved ejection fraction (HFpEF) among men and women in a multiethnic cohort. Coronary artery disease is a risk factor for development of HFpEF and assessment of subclinical atherosclerosis using CAC may allow for the early identification of patients at risk for HFpEF. We used data from the Multi-Ethnic Study of Atherosclerosis. CAC was measured at baseline in all participants. Incident HFpEF was defined as heart failure hospitalization with left ventricular ejection fraction ≥50%...
August 7, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28984635/the-association-between-self-reported-versus-nicotine-metabolite-confirmed-smoking-status-and-coronary-artery-calcification
#15
Byung Jin Kim, Ji Min Han, Jung Gyu Kang, Bum Soo Kim, Jin Ho Kang
OBJECTIVE: There are no data comparing the relationship between coronary artery calcification and self-reported and cotinine-verified smoking. This study was carried out to evaluate the relationship between coronary artery calcium (CAC) and urinary cotinine or self-reported smoking status in Korean adults. PARTICIPANTS AND METHODS: Study participants included 22 797 individuals (19 181 men; mean age±SD 39.2±7.1 years) who were enrolled in the Kangbuk Samsung Health Study and Kangbuk Samsung Cohort Study between 2011 and 2013, and who had urinary cotinine and CAC measurements...
October 3, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28982647/multimodality-intracoronary-imaging-with-near-infrared-spectroscopy-and-intravascular-ultrasound-in-asymptomatic-individuals-with-high-calcium-scores
#16
Ryan D Madder, Stacie VanOosterhout, David Klungle, Abbey Mulder, Matthew Elmore, Jeffrey M Decker, David Langholz, Thomas F Boyden, Jessica Parker, James E Muller
BACKGROUND: This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS: Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS ≥300 Agatston units...
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28981523/associations-between-reflux-esophagitis-and-the-progression-of-coronary-artery-calcification-a-cohort-study
#17
Yang Won Min, Byeong Geun Song, Hye Seung Kim, Kyunga Kim, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Hee Jung Son, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: Reflux esophagitis (RE) and coronary heart disease (CHD) have common risk factors, including obesity and metabolic syndrome. This study aimed to evaluate the associations between RE and the future CHD risk. METHODS: This retrospective cohort study included 8,221 participants who were ≥20 years old, and who underwent esophagogastroduodenoscopy and coronary computed tomography (CT) scans during the same visit and subsequent CT scans between 2003 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28977431/quantity-and-quality-of-graft-flow-in-coronary-artery-bypass-grafting-is-associated-with-cardiac-computed-tomography-study-based-anatomical-and-functional-parameters
#18
Arudo Hiraoka, Satsuki Fukushima, Shigeru Miyagawa, Yasushi Yoshikawa, Shunsuke Saito, Keitaro Domae, Taichi Sakaguchi, Koichi Toda, Yoshiki Sawa
OBJECTIVES: Graft flow in coronary artery bypass grafting (CABG) may be determined by the anatomical and pathological characteristics of the coronary artery and target myocardium. Our goal was to explore the relationships between graft flow and the cardiac/coronary parameters in CABG. METHODS: We enrolled 63 patients who underwent isolated CABG and were examined by cardiac computed tomography. We statistically analysed the correlation between the intraoperative graft flow, such as the mean graft flow (MGF) or the pulsatile index (PI), and the computed tomography scan-based anatomy of the coronary artery tree and the left ventricle in 104 individually bypassed grafts...
July 21, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28977374/incremental-prognostic-value-of-coronary-computed-tomography-angiography-over-coronary-calcium-scoring-for-major-adverse-cardiac-events-in-elderly-asymptomatic-individuals
#19
Donghee Han, Bríain Ó Hartaigh, Heidi Gransar, Ji Hyun Lee, Asim Rizvi, Lohendran Baskaran, Joshua Schulman-Marcus, Allison Dunning, Stephan Achenbach, Mouaz H Al-Mallah, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Erica Maffei, Tracy Q Callister, Kavitha Chinnaiyan, Benjamin J W Chow, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Gilbert Raff, Leslee J Shaw, Todd C Villines, Yong-Jin Kim, Jonathon Leipsic, Gudrun Feuchtner, Ricardo C Cury, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Niree Hindoyan, Erica C Jones, Millie Gomez, Fay Y Lin, Hyuk-Jae Chang, James K Min
Aims: Coronary computed tomography angiography (CCTA) and coronary artery calcium score (CACS) have prognostic value for coronary artery disease (CAD) events beyond traditional risk assessment. Age is a risk factor with very high weight and little is known regarding the incremental value of CCTA over CAC for predicting cardiac events in older adults. Methods and results: Of 27 125 individuals undergoing CCTA, a total of 3145 asymptomatic adults were identified...
July 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28977363/coronary-artery-calcium-score-and-the-long-term-risk-of-atrial-fibrillation-in-patients-undergoing-non-contrast-cardiac-computed-tomography-for-suspected-coronary-artery-disease-a-danish-registry-based-cohort-study
#20
Nicklas Vinter, Amanda M S Christesen, Leif S Mortensen, Grazina Urbonaviciene, Jes Lindholt, Søren P Johnsen, Lars Frost
Aims: To examine the association between coronary artery calcium score (CACS) and risk of future atrial fibrillation (AF), and to estimate the predictive accuracy of CACS for AF development in patients undergoing non-contrast cardiac computed tomography (nCCT). Methods and results: We conducted a registry-based cohort study of 27 962 patients suspected of having coronary artery disease and without history of AF who were identified in the Western Denmark Heart Registry...
August 4, 2017: European Heart Journal Cardiovascular Imaging
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