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Aphasia

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https://www.readbyqxmd.com/read/29350575/the-neural-substrates-of-improved-phonological-processing-following-successful-treatment-in-a-case-of-phonological-alexia-and-agraphia
#1
Andrew T DeMarco, Stephen M Wilson, Kindle Rising, Steven Z Rapcsak, Pélagie M Beeson
Phonological deficits are common in aphasia after left-hemisphere stroke, and can have significant functional consequences for spoken and written language. While many individuals improve through treatment, the neural substrates supporting improvements are poorly understood. We measured brain activation during pseudoword reading in an individual through two treatment phases. Improvements were associated with greater activation in residual left dorsal language regions and bilateral regions supporting attention and effort...
January 19, 2018: Neurocase
https://www.readbyqxmd.com/read/29349881/speech-and-language-therapists-perspectives-of-therapeutic-alliance-construction-and-maintenance-in-aphasia-rehabilitation-post-stroke
#2
Michelle Lawton, Karen Sage, Gillian Haddock, Paul Conroy, Laura Serrant
BACKGROUND: Therapeutic alliance refers to the interactional and relational processes operating during therapeutic interventions. It has been shown to be a strong determinant of treatment efficacy in psychotherapy, and evidence is emerging from a range of healthcare and medical disciplines to suggest that the construct of therapeutic alliance may in fact be a variable component of treatment outcome, engagement and satisfaction. Although this construct appears to be highly relevant to aphasia rehabilitation, no research to date has attempted to explore this phenomenon and thus consider its potential utility as a mechanism for change...
January 18, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29349852/what-really-matters-to-people-with-aphasia-when-it-comes-to-group-work-a-qualitative-investigation-of-factors-impacting-participation-and-integration
#3
Lucette Lanyon, Linda Worrall, Miranda Rose
BACKGROUND: Participation in a group environment is an inherently complex undertaking for people with aphasia. It involves engaging in multi-person interactions with other people who may have a range of communication strengths and strategies at their disposal. The potential challenges of community aphasia-group participation and practice has had limited attention in the research literature. Evidence from group users have primarily been drawn from the perspective of long-term members or those participating in highly specific and time-bound groups...
January 19, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29349659/-self-and-informant-rating-mood-scales-applied-in-elderly-persons-with-alzheimer-s-dementia-with-or-without-a%C3%A2-language-disorder
#4
Margina Yildirim-Gorter, Djahill Groot, Linda Hermens, Han Diesfeldt, Erik Scherder
INTRODUCTION: Alzheimer's Dementia (AD) may be associated with symptoms of depression. In AD, problems of language expression or understanding will arise sooner or later. The aim of this study was to determine whether elderly persons with AD, with or without a language disorder, experience difficulties understanding and answering mood related questions. In addition to this, it was our object to test the validity of the answers of nurses as informants, on the mood of an elderly client...
January 18, 2018: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/29344472/status-epilepticus-as-an-unusual-manifestation-of-heat-stroke
#5
Won Gu Lee, So-Young Huh, Jin-Hyung Lee, Bong Goo Yoo, Meyung Kug Kim
Heat stroke (HS) is a medical emergency and life threatening condition, characterized by body temperature over 40°C. This can lead to dysfunction of multiple organs such as the heart, liver, kidneys, lungs, blood coagulation system, and central nervous system. Neurological complications include change in consciousness, cerebellar dysfunction, convulsions, aphasia, muscular weakness, and parkinsonism. Cerebellar syndrome is the most common neurological finding in HS. We report a case of HS presenting with status epilepticus, without any other neurological manifestations...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29344470/aphasic-status-epilepticus-associated-with-uremia
#6
Min-Surk Kye, Jung-Ju Lee, Byung-Kun Kim, Ohyun Kwon, Jong Moo Park, Kyusik Kang, Woong-Woo Lee
Aphasic status epilepticus (ASE) is a rare disorder characterized by recurrent aphasia without impairment of other cognitive functions. A 76-year-old woman with chronic kidney disease developed ASE after neglecting peritoneal dialysis. Magnetic resonance imaging failed to demonstrate an appropriate lesion. Electroencephalography demonstrated ictal discharges in the left frontotemporal leads. ASE disappeared after intravenous valproic acid and correction of uremia. This is the first case report of ASE in a patient with acute aggravation of uremia...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29339771/etiology-of-language-network-changes-during-recovery-of-aphasia-after-stroke
#7
Casper A M M van Oers, H Bart van der Worp, L Jaap Kappelle, Mathijs A H Raemaekers, Willem M Otte, Rick M Dijkhuizen
Knowledge of spatiotemporal patterns of language network changes may help in predicting outcome in aphasic stroke patients. Here we assessed language function and performed functional MRI four times during one year to measure language network activation and cerebrovascular reactivity (with breath-holding) in twelve left-hemispheric stroke patients, of whom two dropped out before the final measurement, and eight age-matched controls. Language outcome was related to increase of activation in left and right posterior inferior temporal gyrus over the first year, while activation increase in right inferior frontal gyrus was inversely correlated to language recovery...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338310/therapy-induced-plasticity-in-chronic-aphasia-is-associated-with-behavioral-improvement-and-time-since-stroke
#8
Priya Santhanam, E Susan Duncan, Steven L Small
Cortical reorganization after stroke is thought to underlie functional improvement. Patterns of reorganization may differ depending on the amount of time since the stroke or the degree of improvement. We investigated these issues in a study of brain connectivity changes with aphasia therapy. Twelve individuals with chronic aphasia participated in a 6-week trial of imitation-based speech therapy. We assessed improvement on a repetition test and analyzed effective connectivity during functional magnetic resonance imaging (fMRI) of a speech observation task before and after therapy...
January 16, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29322866/how-does-language-change-after-an-intensive-treatment-on-imitation
#9
Marina Zettin, Marzia Leopizzi, Valentina Galetto
The main aim of our study was to investigate the role of imitation in improving word-finding difficulties in a group of aphasic subjects. For this purpose, we designed software based on the computerised program described by Lee et al. (2010). Seven subjects with aphasia resulting from a brain injury were enrolled in the study. A battery of tests was administered to participants one month before the treatment (T0) and immediately before its beginning (T1) with the aim of detecting their language difficulties...
January 11, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29320876/-it-s-not-really-worth-my-while-understanding-contextual-factors-contributing-to-decisions-to-participate-in-community-aphasia-groups
#10
Lucette Lanyon, Linda Worrall, Miranda Rose
PURPOSE: Community aphasia groups represent a formalised opportunity for social participation. The potential barriers and facilitators to accessing and maintaining group participation remain poorly understood. The aim of this study was to explore environmental and personal factors contributing to community aphasia group participation. METHODS: A framework analysis (FA) was used to analyse the semi-structured interview data from 22 current and past members of community aphasia groups...
January 10, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29314772/the-contribution-of-executive-control-to-semantic-cognition-convergent-evidence-from-semantic-aphasia-and-executive-dysfunction
#11
Hannah E Thompson, Azizah Almaghyuli, Krist A Noonan, Ohr Barak, Matthew A Lambon Ralph, Elizabeth Jefferies
Semantic cognition, as described by the controlled semantic cognition (CSC) framework (Rogers et al., , Neuropsychologia, 76, 220), involves two key components: activation of coherent, generalizable concepts within a heteromodal 'hub' in combination with modality-specific features (spokes), and a constraining mechanism that manipulates and gates this knowledge to generate time- and task-appropriate behaviour. Executive-semantic goal representations, largely supported by executive regions such as frontal and parietal cortex, are thought to allow the generation of non-dominant aspects of knowledge when these are appropriate for the task or context...
January 3, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29314421/cognate-effects-and-cognitive-control-in-patients-with-parallel-and-differential-bilingual-aphasia
#12
Lize Van der Linden, Nele Verreyt, Miet De Letter, Dimitri Hemelsoet, Peter Mariën, Patrick Santens, Michaël Stevens, Arnaud Szmalec, Wouter Duyck
BACKGROUND: Until today, there is no satisfying explanation for why one language may recover worse than another in differential bilingual aphasia. One potential explanation that has been largely unexplored is that differential aphasia is the consequence of a loss of language control rather than a loss of linguistic representations. Language control is part of a general control mechanism that also manages non-linguistic cognitive control. If this system is impaired, patients with differential aphasia could still show bilingual language activation, but they may be unable to manage activation in non-target languages, so that performance in another language is hindered...
January 4, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29309976/loss-of-subcortical-language-pathways-correlates-with-surgery-related-aphasia-in-brain-tumor-patients-an-investigation-via-rtms-based-dti-fiber-tracking
#13
Chiara Negwer, Eva Beurskens, Nico Sollmann, Stefanie Maurer, Sebastian Ille, Katrin Giglhuber, Jan S Kirschke, Florian Ringel, Bernhard Meyer, Sandro M Krieg
BACKGROUND: Within language function research there is a shift of focus from cortical specialization to a more hodotopical view including subcortical fiber tracts in functional and oncological considerations. Diffusion tensor imaging fiber tracking (DTI FT) is well established to visualize subcortical fiber tracts. Recently a new technique was developed using cortical regions mapped via repetitive navigated transcranial magnetic stimulation (rTMS) as seed regions. This study investigates if rTMS-based DTI FT for language pathways is also feasible postoperatively and whether pre- vs...
January 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29309493/rates-of-amyloid-imaging-positivity-in-patients-with-primary-progressive-aphasia
#14
Miguel A Santos-Santos, Gil D Rabinovici, Leonardo Iaccarino, Nagehan Ayakta, Gautam Tammewar, Iryna Lobach, Maya L Henry, Isabel Hubbard, Maria Luisa Mandelli, Edoardo Spinelli, Zachary A Miller, Peter S Pressman, James P O'Neil, Pia Ghosh, Andreas Lazaris, Marita Meyer, Christa Watson, Soo Jin Yoon, Howard J Rosen, Lea Grinberg, William W Seeley, Bruce L Miller, William J Jagust, Maria Luisa Gorno-Tempini
Importance: The ability to predict the pathology underlying different neurodegenerative syndromes is of critical importance owing to the advent of molecule-specific therapies. Objective: To determine the rates of positron emission tomography (PET) amyloid positivity in the main clinical variants of primary progressive aphasia (PPA). Design, Setting, and Participants: This prospective clinical-pathologic case series was conducted at a tertiary research clinic specialized in cognitive disorders...
January 8, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29306185/pre-stroke-employment-results-in-better-patient-reported-outcomes-after-minor-stroke-short-title-functional-outcomes-after-minor-stroke
#15
Elisabeth B Marsh, Erin Lawrence, Argye E Hillis, Karen Chen, Rebecca F Gottesman, Rafael H Llinas
OBJECTIVE: Individuals with "minor stroke" lack a dense hemiparesis or aphasia; however, commonly endorse persistent cognitive and motor problems despite low NIHSS scores. They also report problems with mood, energy, and the ability to think clearly that are less well characterized. Socioeconomic factors and stroke severity can influence patient-reported outcomes. In this study we explore patient-reported outcomes and the influence of these factors after minor stroke. PATIENTS AND METHODS: Patients returning to clinic post-stroke with an NIHSS of ≤ 4 were administered a scale to quantify problems with daily activities and resulting functional burden, along with measures of fatigue and depression...
December 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29305438/asymmetric-tdp-pathology-in-primary-progressive-aphasia-with-right-hemisphere-language-dominance
#16
Garam Kim, Shahrooz Vahedi, Tamar Gefen, Sandra Weintraub, Eileen H Bigio, Marek-Marsel Mesulam, Changiz Geula
OBJECTIVE: To quantitatively examine the regional densities and hemispheric distribution of the 43-kDa transactive response DNA-binding protein (TDP-43) inclusions, neurons, and activated microglia in a left-handed patient with right hemisphere language dominance and logopenic-variant primary progressive aphasia (PPA). METHODS: Phosphorylated TDP-43 inclusions, neurons, and activated microglia were visualized with immunohistochemical and histologic methods. Markers were quantified bilaterally with unbiased stereology in language- and memory-related cortical regions...
January 5, 2018: Neurology
https://www.readbyqxmd.com/read/29304167/the-language-disorder-of-prion-disease-is-characteristic-of-a-dynamic-aphasia-and-is-rarely-an-isolated-clinical-feature
#17
Diana Caine, Akin Nihat, Philippa Crabb, Peter Rudge, Lisa Cipolotti, John Collinge, Simon Mead
BACKGROUND: Akinetic mutism is a key diagnostic feature of prion diseases, however, their rapidly progressive nature makes detailed investigation of the language disorder in a large cohort extremely challenging. This study aims to position prion diseases in the nosology of language disorders and improve early clinical recognition. METHODS: A systematic, prospective investigation of language disorders in a large cohort of patients diagnosed with prion diseases. 568 patients were included as a sub-study of the National Prion Monitoring Cohort...
2018: PloS One
https://www.readbyqxmd.com/read/29303140/optic-disc-coloboma-in-two-nigerian-siblings-case-report-and-review-of-literature
#18
Y O Babalola, O O Olawoye, P O Idam
We report two cases of bilateral asymmetric optic disc coloboma (ODC) in siblings. The index patient is a 9-year-old Nigerian girl with severe cognitive deficit who presented with a poor vision of 3 years' duration. She had a history of childhood febrile convulsions and delayed developmental milestones. Her visual acuity could not be assessed because she had a cognitive deficit and expressive aphasia. Ocular examination revealed a very large excavated right optic disc with only a strip of remnant neuro-retinal rim superiorly, and a smaller left optic disc with inferior disc excavation, superior wedge of the pink neuro-retinal rim as well as a temporal optic disc pit...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29300972/a-recurrent-de-novo-missense-mutation-in-ubtf-causes-developmental-neuroregression
#19
Camilo Toro, Roderick T Hori, May Christine V Malicdan, Cynthia J Tifft, Amy Goldstein, William A Gahl, David R Adams, Fauni Harper, Lynne A Wolfe, Jianfeng Xiao, Mohammad M Khan, Jun Tian, Kevin A Hope, Lawrence T Reiter, Michel G Tremblay, Thomas Moss, Alexis L Franks, Chris Balak, Mark S LeDoux
UBTF (upstream binding transcription factor) exists as two isoforms; UBTF1 regulates rRNA transcription by RNA polymerase 1, whereas UBTF2 regulates mRNA transcription by RNA polymerase 2. Herein, we describe 4 patients with very similar patterns of neuroregression due to recurrent de novo mutations in UBTF (GRCh37/hg19, NC_000017.10:g.42290219C>T, NM_014233.3:c.628G>A) resulting in the same amino acid change in both UBTF1 and UBTF2 (p.Glu210Lys [p.E210K]). Disease onset in our cohort was at 2.5 to 3 yrs and characterized by slow progression of global motor, cognitive and behavioral dysfunction...
January 2, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29299104/crossed-aphasia-in-a-patient-with-anaplastic-astrocytoma-of-the-non-dominant-hemisphere
#20
Stephanie Prater, Neil Anand, Lawrence Wei, Neil Horner
Aphasia describes a spectrum of speech impairments due to damage in the language centers of the brain. Insult to the inferior frontal gyrus of the dominant cerebral hemisphere results in Broca's aphasia - the inability to produce fluent speech. The left cerebral hemisphere has historically been considered the dominant side, a characteristic long presumed to be related to a person's "handedness". However, recent studies utilizing fMRI have shown that right hemispheric dominance occurs more frequently than previously proposed and despite a person's handedness...
September 2017: Journal of Radiology Case Reports
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