Anna Marie Buchanan, Sergio Mena, Iman Choukari, Aditya Vasa, Jesseca N Crawford, Jim Fadel, Nick Maxwell, Lawrence Reagan, Allie Cruikshank, Janet Best, H Fred Nijhout, Michael Reed, Parastoo Hashemi
BACKGROUND: Loss of dopaminergic neurons underlies the motor symptoms of Parkinson's disease (PD). However stereotypical PD symptoms only manifest after approximately 80% of dopamine neurons have died making dopamine-related motor phenotypes unreliable markers of the earlier stages of the disease. There are other non-motor symptoms, such as depression, that may present decades before motor symptoms. METHODS: Because serotonin is implicated in depression, here we use niche, fast electrochemistry paired with mathematical modelling and machine learning to, for the first time, robustly evaluate serotonin neurochemistry in vivo in real time in a toxicological model of Parkinsonism, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
March 1, 2024: Molecular Medicine