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https://www.readbyqxmd.com/read/29914971/epigenetic-maintenance-of-topological-domains-in-the-highly-rearranged-gibbon-genome
#1
Nathan H Lazar, Kimberly A Nevonen, Brendan O'Connell, Christine McCann, Rachel J O'Neill, Richard E Green, Thomas J Meyer, Mariam Okhovat, Lucia Carbone
The relationship between evolutionary genome remodeling and the three-dimensional structure of the genome remain largely unexplored. Here, we use the heavily rearranged gibbon genome to examine how evolutionary chromosomal rearrangements impact genome-wide chromatin interactions, topologically associating domains (TADs), and their epigenetic landscape. We use high-resolution maps of gibbon-human breaks of synteny (BOS), apply Hi-C in gibbon, measure an array of epigenetic features, and perform cross-species comparisons...
June 18, 2018: Genome Research
https://www.readbyqxmd.com/read/29910326/the-impact-of-120-minutes-of-match-play-on-recovery-and-subsequent-match-performance-a-case-report-in-professional-soccer-players
#2
Nathan Winder, Mark Russell, Robert J Naughton, Liam D Harper
The influence of a match including extra-time (ET) on subsequent 90 min match performance and recovery has not been investigated. Four professional soccer players played in three competitive matches in a 7-day period: matches one (MD1) and three (MD3) lasted 90 min and match 2 (MD2) lasted 120 min (i.e., included ET). Physical (total and high-intensity (HI) distance covered, accelerations and decelerations, and mechanical load) and technical performances (pass and dribble accuracy) were analyzed throughout match-play...
March 13, 2018: Sports
https://www.readbyqxmd.com/read/29909732/cognitive-outcomes-after-cochlear-implantation-in-older-adults-a-systematic-review
#3
Annes J Claes, Paul Van de Heyning, Annick Gilles, Vincent Van Rompaey, Griet Mertens
OBJECTIVES: To critically assess the current status of the literature on cognitive outcomes after cochlear implantation in older adults. METHODS: Studies were identified by searching MEDLINE (PubMed) and Cochrane Library, and checking reference lists of relevant articles. No restrictions were imposed regarding language, publication date, or publication status. Eligibility criteria were as follows: (1) the study sample included older adults aged 50 or over with severe to profound bilateral hearing loss, (2) the participants received a multi-electrode cochlear implant, and (3) a cognitive test was performed before and after implantation...
June 18, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29907798/congenital-hyperinsulinism-as-the-presenting-feature-of-kabuki-syndrome-clinical-and-molecular-characterization-of-10-affected-individuals
#4
Kai Lee Yap, Amy E Knight Johnson, David Fischer, Priscilla Kandikatla, Jacea Deml, Viswateja Nelakuditi, Sara Halbach, George S Jeha, Lindsay C Burrage, Olaf Bodamer, Valeria C Benavides, Andrea M Lewis, Sian Ellard, Pratik Shah, Declan Cody, Alejandro Diaz, Aishwarya Devarajan, Lisa Truong, Siri Atma W Greeley, Diva D De Leó-Crutchlow, Andrew C Edmondson, Soma Das, Paul Thornton, Darrel Waggoner, Daniela Del Gaudio
PURPOSE: Describe the clinical and molecular findings of patients with Kabuki syndrome (KS) who present with hypoglycemia due to congenital hyperinsulinism (HI), and assess the incidence of KS in patients with HI. METHODS: We documented the clinical features and molecular diagnoses of 10 infants with persistent HI and KS via a combination of sequencing and copy-number profiling methodologies. Subsequently, we retrospectively evaluated 100 infants with HI lacking a genetic diagnosis, for causative variants in KS genes...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29907314/relationship-between-cardiac-mr-compression-classification-and-ct-chest-wall-indexes-in-patients-with-pectus-excavatum
#5
Alejandro Deviggiano, Patricia Carrascosa, Javier Vallejos, Gaston Bellia-Munzon, Natalia Vina, Gaston A Rodríguez-Granillo, Marcelo Martinez-Ferro
BACKGROUND/PURPOSE: In pectus excavatum (PE) patients owing to the location of the heart in the chest cavity, the most affected site of compression by the depressed chest wall is the right heart, and surgical repair has shown to provide a significant relief in the RH cavities compression. Our aim was to explore the relationship between the site of right cardiac compression, chest wall indexes (CT-CWI) and the sternal torsion angle (STA) based on cardiac magnetic resonance (CMR) and computed tomography (CT) among PE patients...
May 23, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29906470/the-effect-of-intracerebroventricular-allopregnanolone-on-depressive-like-behaviors-of-rats-selectively-bred-for-high-and-low-immobility-in-the-forced-swim-test
#6
Felipe Borges Almeida, Alan Rios Fonseca, Núbia Heidrich, Maurício Schüler Nin, Helena Maria Tannhauser Barros
Depression is a highly incapacitating disorder known to have a multifactorial etiology, including a hereditary genetic background. The neurosteroid allopregnanolone (ALLO) is a positive allosteric modulator of the GABAA receptor and has been shown to have an antidepressant-like effect in animals. This study aimed to assess the behavioral effect of ALLO in animals with different backgrounds of depressive-like activity. An initial population (F0) of male and female Wistar rats was screened for immobility behavior utilizing the Forced Swim Test (FST)...
June 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29906242/angiotensin-ii-receptor-i-blockade-prevents-stenosis-of-tissue-engineered-vascular-grafts
#7
Juan de Dios Ruiz-Rosado, Yong-Ung Lee, Nathan Mahler, Tai Yi, Frank Robledo-Avila, Diana Martinez-Saucedo, Avione Y Lee, Toshihiro Shoji, Eric Heuer, Andrew R Yates, Jordan S Pober, Toshiharu Shinoka, Santiago Partida-Sanchez, Christopher K Breuer
We previously developed a tissue-engineered vascular graft (TEVG) made by seeding autologous cells onto a biodegradable tubular scaffold, in an attempt to create a living vascular graft with growth potential for use in children undergoing congenital heart surgery. Results of our clinical trial showed that the TEVG possesses growth capacity but that its widespread clinical use is not yet advisable due to the high incidence of TEVG stenosis. In animal models, TEVG stenosis is caused by increased monocytic cell recruitment and its classic ("M1") activation...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29905955/co-expression-of-lag3-and-tim3-identifies-a-potent-treg-population-that-suppresses-macrophage-functions-in-colorectal-cancer-patients
#8
Qiang Ma, Junning Liu, Guoliang Wu, Mujian Teng, Shaoxuan Wang, Meng Cui, Yuantao Li
Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3+  Treg accumulation in the tumor was associated with poor prognosis. Hence, we examined the circulating Treg cells in CRC patients. Compared to controls, CRC patients presented mild upregulations in CD4+ CD25+/hi T cells and in the more canonical CD4+ CD25+/hi Foxp3+ Treg cells in peripheral blood mononuclear cells. Both of these Treg populations could be roughly divided into LAG3- TIM3- and LAG3+ TIM3+ subsets...
June 15, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29905865/impact-of-naturally-occurring-variation-in-the-human-papillomavirus-hpv-58-capsid-proteins-on-recognition-by-type-specific-neutralizing-antibodies
#9
Anna Godi, Marianna Martinelli, Mahmoud Haque, Shaowei Li, Qinjian Zhao, Ningshao Xia, Clementina E Cocuzza, Simon Beddows
Background: Naturally-occurring variants of Human papillomavirus (HPV) 58 have been defined as lineages and sublineages but little is known about the impact of this diversity on protein function. We investigate the impact of variation within the major (L1) and minor (L2) capsid proteins of HPV58 on susceptibility to neutralizing antibodies. Methods: Pseudovirus (PsV) representing A1, A2, A3, B1, B2, C, D1 and D2 variants were evaluated for their susceptibility to antibodies elicited during natural infection, preclinical antisera generated against virus-like particles and monoclonal antibodies (MAbs)...
June 13, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29902809/metabolic-power-in-team-sports-part-2-aerobic-and-anaerobic-energy-yields
#10
Cristian Osgnach, Pietro Enrico di Prampero
A previous approach to estimate the time course of instantaneous metabolic power and O2 consumption in team sports has been updated to assess also energy expenditure against air resistance and to identify walking and running separately. Whole match energy expenditure turned out ≈14% smaller than previously obtained, the fraction against the air resistance amounting to ≈2% of the total. Estimated net O2 consumption and overall energy expenditure are fairly close to those measured by means of a portable metabolic cart; the average difference, after a 45 min exercise period of variable intensity and mode, amounting to ≈10%...
June 14, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29902498/the-prevalence-of-aflatoxin-m1-in-milk-of-middle-east-region-a-systematic-review-meta-analysis-and-probabilistic-health-risk-assessment
#11
Jamal Rahmani, Solmaz Alipour, Ali Miri, Yadolah Fakhri, Seyed-Mohammad Riahi, Hassan Keramati, Masoud Moradi, Nazak Amanidaz, Rokhsane Hosseini Pouya, Zohreh Bahmani, Amin Mousavi Khaneghah
The current investigation was undertaken to take a review of the performed studies regarding the concentration and prevalence of aflatoxin M1 (AFM1 ) of the consumed cow milk in the Middle East. In this context, all available studies published in databases include Science Direct, PubMed, Scopus, and Web of Science among 1995 to December 2017; were screened accordingly. Also, the carcinogenic risk was estimated by calculating hazard index (HI) using the Monte Carlo simulation (MCS). The result of conducted meta-analysis for 49 articles containing 7484 data indicated that the rank order of type of milk based on the concentration of aflatoxin M1 was Ultra-high temperature processing (UHT) milk (82...
June 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29901812/galaxy-hicexplorer-a-web-server-for-reproducible-hi-c-data-analysis-quality-control-and-visualization
#12
Joachim Wolff, Vivek Bhardwaj, Stephan Nothjunge, Gautier Richard, Gina Renschler, Ralf Gilsbach, Thomas Manke, Rolf Backofen, Fidel Ramírez, Björn A Grüning
Galaxy HiCExplorer is a web server that facilitates the study of the 3D conformation of chromatin by allowing Hi-C data processing, analysis and visualization. With the Galaxy HiCExplorer web server, users with little bioinformatic background can perform every step of the analysis in one workflow: mapping of the raw sequence data, creation of Hi-C contact matrices, quality assessment, correction of contact matrices and identification of topological associated domains (TADs) and A/B compartments. Users can create publication ready plots of the contact matrix, A/B compartments, and TADs on a selected genomic locus, along with additional information like gene tracks or ChIP-seq signals...
June 13, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29901068/mitotic-kinase-pbk-topk-as-a-therapeutic-target-for-adult-t%C3%A2-cell-leukemia-lymphoma
#13
Chie Ishikawa, Masachika Senba, Naoki Mori
Adult T‑cell leukemia/lymphoma (ATLL) is a disorder involving human T-cell leukemia virus type 1 (HTLV‑1)-infected T‑cells characterized by increased clonal neoplastic proliferation. PDZ-binding kinase (PBK) [also known as T‑lymphokine-activated killer cell-originated protein kinase (TOPK)] is a serine/threonine kinase expressed in proliferative cells and is phosphorylated during mitosis. In this study, the expression and phosphorylation of PBK/TOPK were examined by western blot analysis and RT‑PCR...
June 1, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29900125/genome-wide-analysis-of-interchromosomal-interaction-probabilities-reveals-chained-translocations-and-overrepresentation-of-translocation-breakpoints-in-genes-in-a-cutaneous-t-cell-lymphoma-cell-line
#14
Anne Steininger, Grit Ebert, Benjamin V Becker, Chalid Assaf, Markus Möbs, Christian A Schmidt, Piotr Grabarczyk, Lars R Jensen, Grzegorz K Przybylski, Matthias Port, Andreas W Kuss, Reinhard Ullmann
In classical models of tumorigenesis, the accumulation of tumor promoting chromosomal aberrations is described as a gradual process. Next-generation sequencing-based methods have recently revealed complex patterns of chromosomal aberrations, which are beyond explanation by these classical models of karyotypic evolution of tumor genomes. Thus, the term chromothripsis has been introduced to describe a phenomenon, where temporarily and spatially confined genomic instability results in dramatic chromosomal rearrangements limited to segments of one or a few chromosomes...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29899587/initial-investigations-of-a-special-high-definition-hi-def-zoom-capability-in-a-new-detector-system-for-neuro-interventional-procedures
#15
S V Setlur Nagesh, A Shankar, J Krebs, J Hinaman, D R Bednarek, S Rudin
Real-time visualization of fine details ranging to 100 um or less in neuro-vascular imaging guided interventions is important. A separate high-resolution detector mounted on a standard flat panel detector (FPD) was previously reported. This device had to be rotated mechanically into position over the FPD for high resolution imaging. Now, the new detector reported here has a high definition (Hi-Def) zoom capability along with the FPD built into one unified housing. The new detector enables rapid switching, by the operator between Hi-Def and FPD modes...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29897786/newcastle-disease-virus-is-an-updated-attenuated-vaccine-needed
#16
Ehud Shahar, Ruth Haddas, Dana Goldenberg, Avishai Lublin, Itai Bloch, Noa Bachner Hinenzon, Jacob Pitcovski
Newcastle disease virus (NDV) is a major cause of infectious mortality and morbidity in poultry worldwide. It is an enveloped virus with two outer-membrane proteins-hemagglutinin-neuraminidase (HN) and fusion protein (F)-that induce neutralizing antibodies. All NDV strains belong to one serotype. Yet, NDV vaccines, derived from genotype II, do not fully prevent infection or shedding of viruses from other genotypes. The aim of this study was to test if an updated vaccine is required. For this purpose, NDVs isolated from infected, albeit heavily vaccinated flocks, were genetically and immunologically characterized...
June 13, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29896429/invasion-of-peripheral-immune-cells-into-brain-parenchyma-after-cardiac-arrest-and-resuscitation
#17
Can Zhang, Nicole R Brandon, Kerryann Koper, Pei Tang, Yan Xu, Huanyu Dou
Although a direct link has long been suspected between systemic immune responses and neuronal injuries after stroke, it is unclear which immune cells play an important role. A question remains as to whether the blood brain barrier (BBB) is transiently disrupted after circulatory arrest to allow peripheral immune cells to enter brain parenchyma. Here, we developed a clinically relevant cardiac arrest and resuscitation model in mice to investigate the BBB integrity using noninvasive magnetic resonance imaging...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29894689/non-conventional-inhibitory-cd4-foxp3-pd-1-hi-t-cells-as-a-biomarker-of-immune-checkpoint-blockade-activity
#18
Roberta Zappasodi, Sadna Budhu, Matthew D Hellmann, Michael A Postow, Yasin Senbabaoglu, Sasikanth Manne, Billel Gasmi, Cailian Liu, Hong Zhong, Yanyun Li, Alexander C Huang, Daniel Hirschhorn-Cymerman, Katherine S Panageas, E John Wherry, Taha Merghoub, Jedd D Wolchok
A significant proportion of cancer patients do not respond to immune checkpoint blockade. To better understand the molecular mechanisms underlying these treatments, we explored the role of CD4+ Foxp3- T cells expressing PD-1 (4PD1hi ) and observed that 4PD1hi accumulate intratumorally as a function of tumor burden. Interestingly, CTLA-4 blockade promotes intratumoral and peripheral 4PD1hi increases in a dose-dependent manner, while combination with PD-1 blockade mitigates this effect and improves anti-tumor activity...
June 11, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29894380/the-emotional-communication-in-hearing-questionnaire-emo-cheq-development-and-evaluation
#19
Gurjit Singh, Lisa Liskovoi, Stefan Launer, Frank Russo
OBJECTIVES: The objectives of this research were to develop and evaluate a self-report questionnaire (the Emotional Communication in Hearing Questionnaire or EMO-CHeQ) designed to assess experiences of hearing and handicap when listening to signals that contain vocal emotion information. DESIGN: Study 1 involved internet-based administration of a 42-item version of the EMO-CHeQ to 586 adult participants (243 with self-reported normal hearing [NH], 193 with self-reported hearing impairment but no reported use of hearing aids [HI], and 150 with self-reported hearing impairment and use of hearing aids [HA])...
June 11, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29893797/antibody-responses-to-influenza-a-h1n1pdm09-virus-after-pandemic-and-seasonal-influenza-vaccination-in-healthcare-workers-a-five-year-follow-up-study
#20
Mai-Chi Trieu, Åsne Jul-Larsen, Marianne Sævik, Anders Madsen, Jane Kristin Nøstbakken, Fan Zhou, Steinar Skrede, Rebecca Jane Cox
Background: The 2009 influenza pandemic was caused by A/H1N1pdm09 virus, which was subsequently included in the seasonal vaccine as the A/H1N1 strain up to 2016/17. This provided a unique opportunity to investigate the antibody response to H1N1pdm09 over time. Methods: Healthcare workers (HCWs) were immunized with the AS03-adjuvanted H1N1pdm09 vaccine in 2009 (N=250), and subsequently vaccinated with seasonal vaccines containing H1N1pdm09 for 4 seasons (repeated group), <4 seasons (occasional group), or received no further vaccinations (single group)...
June 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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