keyword
MENU ▼
Read by QxMD icon Read
search

Hi

keyword
https://www.readbyqxmd.com/read/29031042/humoral-and-cellular-immune-response-of-mice-challenged-with-yersinia-pestis-antigenic-preparations
#1
Elida A Leal, Josimar D Moreira, Fernanda F Nunes, Larissa R Souza, Janaina M Martins, Vicente P C Toledo, Alzira M P Almeida, Tania M P Guimarães
OBJECTIVES: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response...
October 11, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028432/coadministration-of-recombinant-adenovirus-expressing-gm-csf-with-inactivated-h5n1-avian-influenza-vaccine-increased-the-immune-responses-and-protective-efficacy-against-a-wild-bird-source-of-h5n1-challenge
#2
Xiangwei Wang, Xinglong Wang, Yanqing Jia, Chongyang Wang, Qiuxia Tang, Qingsong Han, Sa Xiao, Zengqi Yang
Wild birds play a key role in the spread of avian influenza virus (AIV). There is a continual urgent requirement for AIV vaccines to address the ongoing genetic changes of AIV. In the current study, we trialed a novel AIV vaccine against the wild bird source of H5N1 type AIV with recombinant adenovirus expressing granulocyte monocyte colony-stimulating factor (GM-CSF) as an adjuvant. A total of 150-day-old commercial chicks, with AIV-maternal-derived antibody, were divided into 6 groups. The primary vaccination was performed at day 14 followed by a subsequent boosting and intramuscular challenge on day 28 and 42, respectively...
October 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29027112/field-synopsis-and-re-analysis-of-systematic-meta-analyses-of-genetic-association-studies-in-multiple-sclerosis-a-bayesian-approach
#3
Jae Hyon Park, Joo Hi Kim, Kye Eun Jo, Se Whan Na, Michael Eisenhut, Andreas Kronbichler, Keum Hwa Lee, Jae Il Shin
To provide an up-to-date summary of multiple sclerosis-susceptible gene variants and assess the noteworthiness in hopes of finding true associations, we investigated the results of 44 meta-analyses on gene variants and multiple sclerosis published through December 2016. Out of 70 statistically significant genotype associations, roughly a fifth (21%) of the comparisons showed noteworthy false-positive rate probability (FPRP) at a statistical power to detect an OR of 1.5 and at a prior probability of 10(-6) assumed for a random single nucleotide polymorphism...
October 12, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29026790/the-prevalence-of-hearing-impairment-by-age-and-gender-in-a-population-based-study
#4
Alimohamad Asghari, Mohammad Farhadi, Ahmad Daneshi, Mehdi Khabazkhoob, Saman Mohazzab-Torabi, Maryam Jalessi, Hesamedin Emamjomeh
BACKGROUND: This study aimed to determine the prevalence of hearing impairment (HI) by age and gender in a population aged 5 yr and older residing in Tehran, Iran. METHODS: In this cross-sectional study, 140 clusters each including 10 households from Tehran, Iran were sampled between 2012 and 2013 using cluster random sampling. Trained audiologists examined the participants during face-to-face interviews. The hearing of the participants was evaluated before the removal of wax or other foreign bodies...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29026264/more-to-lose-noise-risk-perceptions-of-young-adults-with-hearing-impairment
#5
REVIEW
Lyndal Carter, Deborah Black
This study investigated the attitudes and behaviors of young adults with hearing impairment (HI), in relation to leisure noise. It was hypothesized that young people with HI would have more negative perceptions of noise exposure than their peers with nonimpaired (normal) hearing (NH) and would engage more frequently in self-protective behaviors. Questionnaires were administered as part of a larger study of young Australians with: (1) preadult onset HI and (2) NH. Data from adults (age range 18 to 24 years; n  = 79 with HI, n  = 131 with NH) were selected for the current analysis...
November 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/29025761/genome-wide-association-study-to-find-modifiers-for-tetralogy-of-fallot-in-the-22q11-2-deletion-syndrome-identifies-variants-in-the-gpr98-locus-on-5q14-3
#6
Tingwei Guo, Gabriela M Repetto, Donna M McDonald McGinn, Jonathan H Chung, Hiroko Nomaru, Christopher L Campbell, Anna Blonska, Anne S Bassett, Eva W C Chow, Elisabeth E Mlynarski, Ann Swillen, Joris Vermeesch, Koen Devriendt, Doron Gothelf, Miri Carmel, Elena Michaelovsky, Maude Schneider, Stephan Eliez, Stylianos E Antonarakis, Karlene Coleman, Aoy Tomita-Mitchell, Michael E Mitchell, M Cristina Digilio, Bruno Dallapiccola, Bruno Marino, Nicole Philip, Tiffany Busa, Leila Kushan-Wells, Carrie E Bearden, Małgorzata Piotrowicz, Wanda Hawuła, Amy E Roberts, Flora Tassone, Tony J Simon, Esther D A van Duin, Thérèse A van Amelsvoort, Wendy R Kates, Elaine Zackai, H Richard Johnston, David J Cutler, A J Agopian, Elizabeth Goldmuntz, Laura E Mitchell, Tao Wang, Beverly S Emanuel, Bernice E Morrow
BACKGROUND: The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) occurs in 1 of 4000 live births, and 60% to 70% of affected individuals have congenital heart disease, ranging from mild to severe. In our cohort of 1472 subjects with 22q11.2DS, a total of 62% (n=906) have congenital heart disease and 36% (n=326) of these have tetralogy of Fallot (TOF), comprising the largest subset of severe congenital heart disease in the cohort. METHODS AND RESULTS: To identify common genetic variants associated with TOF in individuals with 22q11...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29025596/rank-and-egfr-in-invasive-breast-carcinoma
#7
Anastasios D Papanastasiou, Chaido Sirinian, Eva Plakoula, Vassiliki Zolota, Ioannis K Zarkadis, Haralabos P Kalofonos
Breast cancer is the most common malignancy, affecting one in eight women in North America and Europe. The human epidermal growth factor receptor (EGFR) protein comprises a major determinant of normal development but also cancer. RANK receptor (Receptor Activator of Nuclear factor-κB) is a tumor necrosis superfamily member and a binding partner for RANKL, which was recently implicated in breast cancer initiation, progression and metastasis. Here we provide preliminary evidence of a possible interplay between RANK and EGFR signaling in breast cancer...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29025183/postoperative-imaging-after-impingement-surgery
#8
Tobias Johannes Dietrich, Karl Grob, Chan-Hi Olaf Kim
No abstract text is available yet for this article.
November 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29024930/effect-of-concurrent-src-kinase-inhibition-with-short-duration-hypothermia-on-ca2-calmodulin-kinase-iv-activity-and-neuropathology-after-hypoxia-ischemia-in-the-newborn-swine-brain
#9
Panagiotis Kratimenos, Ioannis Koutroulis, Amit Jain, Shadi Malaeb, Maria Delivoria-Papadopoulos
BACKGROUND: Hypoxia-ischemia (HI) results in increased activation of Ca2+/calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury in the newborn. HYPOTHESIS: Inhibition of Src kinase concurrently with hypothermia further attenuates the hypoxia-induced increased activation of CaM kinase IV compared with hypothermia alone. DESIGN/METHODS: Ventilated piglets were exposed to HI, received saline or a selective Src kinase inhibitor (PP2), and were cooled to 33°C...
October 13, 2017: Neonatology
https://www.readbyqxmd.com/read/29024884/adsorption-desorption-and-hysteresis-phenomenon-of-tebuconazole-in-colombian-agricultural-soils-experimental-assays-and-mathematical-approaches
#10
Carmen S Mosquera-Vivas, María J Martinez, Glenda García-Santos, Jairo A Guerrero-Dallos
The adsorption-desorption, hysteresis phenomenon, and leachability of tebuconazole were studied for Inceptisol and Histosol soils at the surface (0-10 cm) and in the subsurface (40-50 cm) of an agricultural region from Colombia by the batch-equilibrium method and mathematical approaches. The experimental Kfa and Kd (L kg(-1)) values (7.9-289.2) decreased with depth for the two Inceptisols and increased with depth for the Histosol due to the organic carbon content, aryl and carbonyl carbon types. Single-point and desorption isotherms depended on adsorption reversibility and suggested that tebuconazole showed hysteresis; which can be adequately evaluated with the single-point desorption isotherm and the linear model using the hysteresis index HI...
September 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29022359/health-risks-in-rural-populations-due-to-heavy-metals-found-in-agricultural-soils-irrigated-with-wastewater-in-the-alto-balsas-sub-basin-in-tlaxcala-and-puebla-mexico
#11
Numa Pompilio Castro-González, Francisco Calderón-Sánchez, Rafael Moreno-Rojas, Alicia Moreno-Ortega, José Víctor Tamariz-Flores
The aim of this study was to determine the hazard ratio (HQ), the risk index (HI), and the cancer risk index (CRI) for populations of adults and children exposed to ingestion, dermal contact and inhalation of heavy metals in agricultural soil. For these, the contents of Cd, Pb, Ni, Cu, Co, Cr, Zn, and the metalloid As were determined in soils of four zones of the sub-basin of Alto Balsas, during two different periods of the year. The average content of metals in the soil was 1.24, 14.77, 14.80, 13.06, 5.50, 17...
October 12, 2017: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/29022181/occurrence-of-selected-elements-ti-sr-ba-v-ga-sn-tl-and-sb-in-deposited-dust-and-human-hair-samples-implications-for-human-health-in-pakistan
#12
Syed Ali Musstjab Akber Shah Eqani, Zafar Iqbal Tanveer, Chi Qiaoqiao, Alessandra Cincinelli, Zafeer Saqib, Sikandar I Mulla, Nadeem Ali, Ioannis A Katsoyiannis, Mustafa Nawaz Shafqat, Heqing Shen
The current study determined, for the first time, the levels of titanium (Ti), strontium (Sr), barium (Ba), vanadium (V), gallium (Ga), tin (Sn), thallium (Tl), and antinomy (Sb), in deposited dust, and human hair collected from general population of different geographical areas of Pakistan. All the samples were prepared by microwave digestion and measured by ICP-MS. The results showed that on deposited dust samples, the detected elements followed the descending trend as: Ti > Sr > Ba > V > Ga > Sn > Tl > Sb similar to the upper continental crust...
October 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29021304/kinetics-longevity-and-cross-reactivity-of-anti-neuraminidase-antibody-after-natural-infection-with-influenza-a-viruses
#13
Don Changsom, Li Jiang, Hatairat Lerdsamran, Sopon Iamsirithaworn, Rungrueng Kitphati, Phisanu Pooruk, Prasert Auewarakul, Pilaipan Puthavathana
The kinetics, longevity and breadth of antibodies to influenza neuraminidase (NA) in archival, sequential serum/plasma samples from influenza A virus (IAV) H5N1 survivors, and from patients infected with the 2009 pandemic IAV (H1N1) virus were determined using an enzyme linked lectin based assay. The reverse genetics-derived H4N1 viruses harboring an hemagglutinin (HA) segment from A/duck/Shan Tou/461/2000 (H4N9) and an NA segment derived from either IAV H5N1 clade 1, IAV H5N1 clade 2.3.4, the 2009 pandemic IAV (H1N1) (H1Npdm) or A/Puerto Rico/8/1934 (H1N1) virus were used as the test antigens...
October 11, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29019446/the-role-of-the-oximes-hi-6-and-hs-6-inside-human-acetylcholinesterase-inhibited-with-nerve-agents-a-computational-study
#14
Teobaldo Cuya, Arlan da Silva Gonçalves, Jorge Alberto Valle da Silva, Teodorico C Ramalho, Kamil Kuca, Tanos C C França
Abstracts The oximes 4-carbamoyl-1-[({2-[(E)-(hydroxyimino) methyl] pyridinium-1-yl} methoxy) methyl] pyridinium (known as HI-6) and 3-carbamoyl-1-[({2-[(E)-(hydroxyimino) methyl] pyridinium-1-yl} methoxy) methyl] pyridinium (known as HS-6) are isomers differing from each other only by the position of the carbamoyl group on the pyridine ring. However this slight difference was verified to be responsible for big differences in the percentual of reactivation of acetylcholinesterase (AChE) inhibited by the nerve agents tabun, sarin, cyclosarin and VX...
October 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29018332/the-beneficial-effects-of-melatonin-administration-following-hypoxia-ischemia-in-preterm-fetal-sheep
#15
Tamara Yawno, Mawin Mahen, Jingang Li, Michael C Fahey, Graham Jenkin, Suzanne L Miller
Melatonin (MLT) is an endogenous hormone that controls circadian cycle. MLT has additional important properties that make it appealing as a neuroprotective agent-it is a potent anti-oxidant, with anti-apoptotic and anti-inflammatory properties. MLT is safe for administration during pregnancy or to the newborn after birth, and can reduce white matter brain injury under conditions of chronic fetal hypoxia. Accordingly, in the current study, we examined whether an intermediate dose of MLT could restore white matter brain development when administered after an acute hypoxic ischemic (HI) insult in preterm fetal sheep...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29018327/maternal-cigarette-smoke-exposure-worsens-neurological-outcomes-in-adolescent-offspring-with-hypoxic-ischemic-injury
#16
Yik L Chan, Sonia Saad, Rita Machaalani, Brian G Oliver, Bryce Vissel, Carol Pollock, Nicole M Jones, Hui Chen
Hypoxic-ischemic (HI) encephalopathy occurs in approximately 6 per 1000 term newborns leading to devastating neurological consequences, such as cerebral palsy and seizures. Maternal smoking is one of the prominent risk factors contributing to HI injury. Mitochondrial integrity plays a critical role in neural injury and repair during HI. We previously showed that maternal cigarette smoke exposure (SE) can reduce brain mitochondrial fission and autophagosome markers in male offspring. This was accompanied by increased brain cell apoptosis (active caspase-3) and DNA fragmentation (TUNEL staining)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28994018/memory-cd4-t-cell-subsets-in-tumor-draining-lymph-nodes-of-breast-cancer-patients-a-focus-on-t-stem-cell-memory-cells
#17
Yasmin Vahidi, Zahra Faghih, Abdol-Rasoul Talei, Mehrnoosh Doroudchi, Abbas Ghaderi
BACKGROUND: The compartments of memory T cells play a fundamental role in the immune system by substantiating specific and acquired immunity. A new subset of memory cells, T stem cell memory (TSCM) cells, with stem cell-like properties, a high capacity to proliferate, a long survival, and an ability to differentiate into all effector and memory cells has recently been introduced. In the present study, we aimed to determine the frequency of CD4(+) TSCM and other T memory cell subsets in tumor draining lymph nodes of breast cancer patients...
October 9, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28993768/cd30-is-dispensable-for-t-cell-responses-to-influenza-virus-and-lymphocytic-choriomeningitis-virus-clone-13-but-contributes-to-age-associated-t-cell-expansion-in-mice
#18
Angela C Zhou, Laura M Snell, Michael E Wortzman, Tania H Watts
CD30 is a tumor necrosis factor receptor (TNFR) family member whose expression is associated with Hodgkin's disease, anaplastic large cell lymphomas, and other T and B lymphoproliferative disorders in humans. A limited number of studies have assessed the physiological role of CD30/CD30 ligand interactions in control of infection in mice. Here, we assess the role of CD30 in T-cell immunity to acute influenza and chronic lymphocytic choriomeningitis virus (LCMV) clone 13 infection, two viral infections in which other members of the TNFR superfamily are important for T-cell responses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28993517/revisiting-the-road-map-of-medullary-thymic-epithelial-cell-differentiation
#19
Chloé Michel, Corey N Miller, Rita Küchler, Benedikt Brors, Mark S Anderson, Bruno Kyewski, Sheena Pinto
The basic two-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII)(lo) to mature MHCII(hi) mTECs has recently been extended to include a third stage, namely the post-Aire MHCII(lo) subset as identified by lineage-tracing models. However, a suitable surface marker distinguishing the phenotypically overlapping pre- from the post-Aire MHCII(lo) stage has been lacking. In this study, we introduce the lectin Tetragonolobus purpureas agglutinin (TPA) as a novel cell surface marker that allows for such delineation...
October 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28993251/hypoxia-ischemia-modifies-postsynaptic-glun2b-containing-nmda-receptor-complexes-in-the-neonatal-mouse-brain
#20
Fuxin Lu, Guo Shao, Yongqiang Wang, Shenheng Guan, Alma L Burlingame, Xuemei Liu, Xiao Liang, Renatta Knox, Donna M Ferriero, Xiangning Jiang
The N-methyl-d-aspartate-type glutamate receptor (NMDAR)-associated multiprotein complexes are indispensable for synaptic plasticity and cognitive functions. While purification and proteomic analyses of these signaling complexes have been performed in adult rodent and human brain, much less is known about the protein composition of NMDAR complexes in the developing brain and their modifications by neonatal hypoxic-ischemic (HI) brain injury. In this study, the postsynaptic density proteins were prepared from postnatal day 9 naïve, sham-operated and HI-injured mouse cortex...
October 6, 2017: Experimental Neurology
keyword
keyword
30645
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"