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https://www.readbyqxmd.com/read/29452150/cerebral-blood-flow-velocity-and-autoregulation-in-paediatric-patients-following-a-global-hypoxic-ischaemic-insult
#1
Marlina E Lovett, Tensing Maa, Melissa G Chung, Nicole F O'Brien
AIM: To describe the cerebral blood flow velocity pattern and investigate cerebral autoregulation using transcranial Doppler ultrasonography (TCD) following a global hypoxic-ischaemic (HI) event in children. METHODS: This was a prospective, observational study in a quaternary-level paediatric intensive care unit. Intubated children, newborn to 17 years admitted to the PICU following HI injury (asphyxia, drowning, cardiac arrest) were eligible for inclusion. TCD was performed daily until post-injury day 8, discharge, or death, whichever occurred earliest...
February 13, 2018: Resuscitation
https://www.readbyqxmd.com/read/29451335/mesenchymal-stem-cells-protect-against-hypoxia-ischemia-brain-damage-by-enhancing-autophagy-through-bdnf-mtor-signaling-pathway
#2
Zhen Zheng, Li Zhang, Yi Qu, Guoguang Xiao, Shiping Li, Shan Bao, Richard Lu, Dezhi Mu
Hypoxic-ischemic encephalopathy (HIE) is a serious disease for neonates. However, present therapeutic strategies are not effective enough for treating HIE. Previous study showed that mesenchymal stem cells (MSCs) can exert neuroprotective effects for brain damage, but its mechanism remains elusive. Using in-vitro co-culture of rat cortical primary neurons and MSCs in HI conditions, we demonstrated that MSCs help increase BDNF and autophagy markers (LC3II and Beclin1) in the cultures and decrease cells death (LDH levels)...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29450641/chronic-lymphocytic-leukemia-cells-acquire-regulatory-b-cell-properties-in-response-to-tlr9-and-cd40-activation
#3
Shimrit Ringelstein-Harlev, Irit Avivi, Mona Fanadka, Netanel A Horowitz, Tami Katz
Circulating chronic lymphocytic leukemia (CLL) cells share phenotypic features with certain subsets of regulatory B-cells (Bregs). The latter cells have been reported to negatively regulate immune cell responses, mostly by provision of IL-10. The purpose of the current study was to identify and delineate Breg properties of CLL cells. B-cells and T-cells were obtained from the peripheral blood of untreated CLL patients diagnosed according to the 2008 Guidelines of the International Workshop on Chronic Lymphocytic Leukemia...
February 15, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29449941/cardiovascular-risk-factor-burden-in-africa-and-the-middle-east-across-country-income-categories-a-post-hoc-analysis-of-the-cross-sectional-africa-middle-east-cardiovascular-epidemiological-ace-study
#4
Frederick J Raal, Alawi A Alsheikh-Ali, Mohamed I Omar, Wafa Rashed, Omar Hamoui, Abdoul Kane, Mohamed Alami, Paula Abreu, Walid M Mashhoud
Background: A significant number of cardiovascular disease (CVD)-related deaths occur in developing countries. An increasing prevalence of CVD is associated with a change in the macro-economy of these countries. In this post hoc analysis, CVD risk factor (CVDRF) prevalence is evaluated across countries based on national income in the Africa and Middle East Region (AfME). Methods: Data from the Africa Middle East Cardiovascular Epidemiological (ACE) study were used; a cross-sectional study in 14 AfME countries (94 clinics) from July 2011-April 2012, which evaluated CVDRF prevalence in stable adult outpatients...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29449276/immune-evasion-via-pd-1-pd-l1-on-nk-cells-and-monocyte-macrophages-is-more-prominent-in-hodgkin-lymphoma-than-dlbcl
#5
Frank Vari, David Arpon, Colm Keane, Mark S Hertzberg, Dipti Talaulikar, Sanjiv Jain, Qingyan Cui, Erica Han, Josh Tobin, Robert Bird, Donna Cross, Annette Hernandez, Clare Gould, Simone Birch, Maher K Gandhi
Much focus has been on the interaction of PD-L1 on malignant B-cells with PD-1 on effector T-cells in inhibiting anti-lymphoma immunity. We sought to establish the contribution of NK-cells and inhibitory CD163 + monocytes/macrophages in Hodgkin Lymphoma (cHL) and Diffuse Large B-cell Lymphoma (DLBCL). Levels of PD-1 on NK-cells were elevated in cHL relative to DLBCL. Notably, CD3 - CD56 hi CD16 -ve NK-cells had substantially higher PD-1 expression relative to CD3 - CD56 dim CD16 + cells, and were expanded in blood and tissue, more marked in cHL than DLBCL patients...
February 15, 2018: Blood
https://www.readbyqxmd.com/read/29449103/salmon-calcitonin-and-omega-3-fatty-acids-exhibit-antagonistic-and-non-additive-effects-in-experimental-diabetes
#6
Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Because optimising therapy for the management of diabetes mellitus remains challenging, the study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3 - eicosapentaenoic acid and docosahexaenoic acid-3:2), compared to metformin, on selected biochemical parameters in male Wistar rats, in an experimental model of diabetes. Forty rats were used for this study. They were divided into eight groups of five rats each, which included: Normal control; Diabetic (D) control; D + N-3; D + low dose Sct (Sct...
February 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29448855/acute-effects-of-blood-flow-restriction-on-exercise-induced-free-radical-production-in-young-and-healthy-subjects
#7
Christoph Centner, Denise Zdzieblik, Patrick Dressler, Bruno Fink, Albert Gollhofer, Daniel König
The main purpose of this study was to investigate the acute local and systemic effects of low-load resistance exercise (30% 1RM) with partial vascular occlusion on exercise-induced free radical production and to compare these effects with other established training methods. Fifteen young and healthy males (25 ± 3 years) performed the following four sessions in a counterbalanced order on separate days: low-load resistance exercise (LI: 30% 1RM), low-load resistance exercise with blood flow restriction (LIBR: 30% 1RM), high-load resistance exercise (HI: 80% 1RM) and an additional session without exercise but blood flow restriction only (BR)...
February 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29447253/combined-impairments-in-vision-hearing-and-cognition-are-associated-with-greater-levels-of-functional-and-communication-difficulties-than-cognitive-impairment-alone-analysis-of-interrai-data-for-home-care-and-long-term-care-recipients-in-ontario
#8
Dawn M Guthrie, Jacob G S Davidson, Nicole Williams, Jennifer Campos, Kathleen Hunter, Paul Mick, Joseph B Orange, M Kathleen Pichora-Fuller, Natalie A Phillips, Marie Y Savundranayagam, Walter Wittich
OBJECTIVES: The objective of the current study was to understand the added effects of having a sensory impairment (vision and/or hearing impairment) in combination with cognitive impairment with respect to health-related outcomes among older adults (65+ years old) receiving home care or residing in a long-term care (LTC) facility in Ontario, Canada. METHODS: Cross-sectional analyses were conducted using existing data collected with one of two interRAI assessments, one for home care (n = 291,824) and one for LTC (n = 110,578)...
2018: PloS One
https://www.readbyqxmd.com/read/29445199/lack-of-t-bet-reduces-monocytic-interleukin-12-formation-and-accelerates-thrombus-resolution-in-deep-vein-thrombosis
#9
Tanja Schönfelder, Moritz Brandt, Sabine Kossmann, Tanja Knopp, Thomas Münzel, Ulrich Walter, Susanne H Karbach, Philip Wenzel
The role of leukocytes in deep vein thrombosis (DVT) resolution is incompletely understood. We determined how depletion of lysozyme positive (LysM + ) cells and a switched-off type 1 immune response influences thrombus resolution. DVT was induced in 12-week-old male mice by inferior vena cava (IVC) stenosis. Toxin mediated depletion of myeloid cells improved thrombus resolution in mice with Cre-inducible expression of the diphtheria toxin receptor in LysM + cells. This correlated with decreased CD45 + cells, a population shift of Gr-1 + to Gr-1 - CD11b + myelomonocytic cells (flow cytometry) and an increase in CC-chemokine ligand 2, interleukin-4 and interleukin-10 mRNA expressions...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444980/circulating-t-fh-cells-serological-memory-and-tissue-compartmentalization-shape-human-influenza-specific-b-cell-immunity
#10
Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nüssing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi H O Nguyen, Katherine Kedzierska
Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy to combat seasonal influenza infections. IIV activates B cells and T follicular helper (T FH ) cells and thus engenders antibody-secreting cells and serum antibody titers. However, the cellular events preceding generation of protective immunity in humans are inadequately understood. We undertook an in-depth analysis of B cell and T cell immune responses to IIV in 35 healthy adults. Using recombinant hemagglutinin (rHA) probes to dissect the quantity, phenotype, and isotype of influenza-specific B cells against A/California09-H1N1, A/Switzerland-H3N2, and B/Phuket, we showed that vaccination induced a three-pronged B cell response comprising a transient CXCR5 - CXCR3 + antibody-secreting B cell population, CD21 hi CD27 + memory B cells, and CD21 lo CD27 + B cells...
February 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29442475/association-of-heterogeneity-of-the-thyroid-gland-with-matrix-metalloproteinase-3-in-rheumatoid-arthritis-patients-with-hashimoto-s-thyroiditis
#11
Toshiki Nagasaki, Yuki Nagata, Yosuke Wakita, Shinsuke Yamada, Hitoshi Goto, Yasuo Imanishi, Naoyoshi Onoda, Masanori Emoto, Masaaki Inaba
PURPOSE: Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity. METHODS: Fifty three consecutive RA patients were prospectively separated into two groups on the basis of the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of the thyroid gland, heterogeneity index (HI) was determined ultrasonographically...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29438801/specific-activity-features-in-the-forced-swim-test-brain-neurotrophins-and-development-of-stress-induced-depressive-like-behavior-in-rats
#12
Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaeva
Selective vulnerability or resilience to mood disorders is related to individual differences or personality. In the present study forced swim test (FST) was used as a tool for division of male rats according to their immobility behavior. The animals were subjected to a chronic unpredictable mild stress (CUS). Depressive-like behavior and modifications in brain neurotrophin system of were examined after CUS exposure. The low immobile (LI) and high immobile (HI) rats demonstrated elusive differences in expression of BDNF ExVI mRNA and TrkA mRNA which was higher in hippocampus and frontal cortex, respectively, of HI rats as compared to LI animals...
February 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29435799/influence-of-land-use-on-the-health-of-a-detritivorous-fish-ancistrus-mullerae-endemic-to-the-iguassu-ecoregion-relationship-between-agricultural-land-use-and-severe-histopathological-alterations
#13
Mayara Pereira Neves, João Paulo de Arruda Amorim, Rosilene Luciana Delariva
This study aimed to evaluate the histopathological biomarkers of the gills and liver of endemic catfish to test the hypothesis that, in environments under intense land use by agricultural activities, histopathological alterations occur more severely. Samples were collected by electrofishing in seven streams in the Lower Iguaçu basin quarterly from August 2015 to February 2016. The gills and livers were processed according to routine histological methods and examined by light microscopy. The histopathological alterations observed in fish from the streams with a higher percentage of natural vegetation cover were considered modest and indicated normal functioning of the organ (such as edema, hyperplasia, and leukocyte infiltration)...
February 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29435679/geospatial-distribution-of-metal-loid-s-and-human-health-risk-assessment-due-to-intake-of-contaminated-groundwater-around-an-industrial-hub-of-northern-india
#14
Rachit Kashyap, K S Verma, Sanjay Kr Uniyal, S K Bhardwaj
The study focused on analyzing concentrations of metal(loid)s, their geospatial distribution in groundwater around an industrial hub of northern India. Human health risk posed due to the intake of contaminated groundwater was also evaluated. For this, 240 samples were assayed using inductively coupled plasma emission spectrophotometer. For risk assessment, the methodology proposed by US Environmental Protection Agency was adopted. Geometric mean of Al, As, Mo, Cd, Co, Cr, Fe, Mn, Ni, Pb, Se, and Zn was 193...
February 12, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29435331/systematic-review-of-azacitidine-regimens-in-myelodysplastic-syndrome-and-acute-myeloid-leukemia
#15
Roman M Shapiro, Alejandro Lazo-Langner
Background: 5-Azacitidine administered as a 7-day dosing regimen (7-0-0) is approved in high risk IPSS myelodysplastic syndrome (MDS) patients. Alternative regimens such as a 5-day (5-0-0) or 7-day with a weekend break (5-2-2) are commonly used. No randomized controlled trial has been done directly comparing all three dosing regimens. The objective of this study was to compare the efficacies of the 5-0-0, 5-2-2, and 7-0-0 regimens in MDS and AML. Methods: A systematic review was conducted using MEDLINE, EMBASE and CENTRAL...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29431585/calculation-of-3d-genome-structures-for-comparison-of-chromosome-conformation-capture-experiments-with-microscopy-an-evaluation-of-single-cell-hi-c-protocols
#16
David Lando, Tim J Stevens, Srinjan Basu, Ernest D Laue
Single-cell chromosome conformation capture approaches are revealing the extent of cell-to-cell variability in the organization and packaging of genomes. These single-cell methods, unlike their multi-cell counterparts, allow straightforward computation of realistic chromosome conformations that may be compared and combined with other, independent, techniques to study 3D structure. Here we discuss how single-cell Hi-C and subsequent 3D genome structure determination allows comparison with data from microscopy...
February 12, 2018: Nucleus
https://www.readbyqxmd.com/read/29428748/plane-of-nutrition-before-and-after-6-months-of-age-in-holstein-friesian-bulls-i-effects-on-performance-body-composition-age-at-puberty-and-postpubertal-semen-production
#17
C J Byrne, S Fair, A M English, M Cirot, C Staub, P Lonergan, D A Kenny
The aim of this study was to examine the effect of plane of nutrition (1) during the first 6 mo of life and (2) from 6 mo of age to puberty on early growth characteristics, age at puberty, and postpubertal semen production in Holstein-Friesian bulls. Holstein-Friesian bull calves (n = 83) with a mean (standard deviation) age and body weight of 17 (4.4) d and 52 (6.2) kg, respectively, were assigned to a high (Hi) or low (Lo) plane of nutrition for the first 6 mo of life. The Hi and Lo calves received 1,200 and 450 g of milk replacer, respectively; Hi calves were fed concentrate ad libitum and Lo were fed a maximum of 1 kg concentrate daily, and concentrate allowances remained the same after weaning...
February 7, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29428417/juicebox-js-provides-a-cloud-based-visualization-system-for-hi-c-data
#18
James T Robinson, Douglass Turner, Neva C Durand, Helga Thorvaldsdóttir, Jill P Mesirov, Erez Lieberman Aiden
Contact mapping experiments such as Hi-C explore how genomes fold in 3D. Here, we introduce Juicebox.js, a cloud-based web application for exploring the resulting datasets. Like the original Juicebox application, Juicebox.js allows users to zoom in and out of such datasets using an interface similar to Google Earth. Juicebox.js also has many features designed to facilitate data reproducibility and sharing. Furthermore, Juicebox.js encodes the exact state of the browser in a shareable URL. Creating a public browser for a new Hi-C dataset does not require coding and can be accomplished in under a minute...
February 5, 2018: Cell Systems
https://www.readbyqxmd.com/read/29426351/poly-arginine-r18-and-r18d-d-enantiomer-peptides-reduce-infarct-volume-and-improves-behavioural-outcomes-following-perinatal-hypoxic-ischaemic-encephalopathy-in-the-p7-rat
#19
Adam B Edwards, Jane L Cross, Ryan S Anderton, Neville W Knuckey, Bruno P Meloni
We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of 30, 100, 300 or 1000 nmol/kg immediately after HI (8% O2/92%N2 for 2.5 h). The previously characterised neuroprotective JNKI-1-TATD peptide at a dose of 1000 nmol/kg was used as a control. Infarct volume and behavioural outcomes were measured 48 h after HI. For the R18 and R18D doses examined, total infarct volume was reduced by 25...
February 9, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29425232/identification-and-characterization-of-influenza-a-viruses-in-selected-domestic-animals-in-kenya-2010-2012
#20
Peninah Munyua, Clayton Onyango, Lydia Mwasi, Lilian W Waiboci, Geoffrey Arunga, Barry Fields, Joshua A Mott, Carol J Cardona, Philip Kitala, Philip N Nyaga, M Kariuki Njenga
BACKGROUND: Influenza A virus subtypes in non-human hosts have not been characterized in Kenya. We carried out influenza surveillance in selected domestic animals and compared the virus isolates with isolates obtained in humans during the same period. METHODS: We collected nasal swabs from pigs, dogs and cats; oropharyngeal and cloacal swabs from poultry; and blood samples from all animals between 2010 and 2012. A standardized questionnaire was administered to farmers and traders...
2018: PloS One
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