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https://www.readbyqxmd.com/read/29679871/groundwater-chemistry-and-human-health-risk-assessment-in-the-mining-region-of-east-singhbhum-jharkhand-india
#1
Umesh Kumar Singh, A L Ramanathan, V Subramanian
Groundwater chemistry of mining region of East Singhbhum district having complex contaminant sources were investigated based on heavy metals loads and other hydrochemical constituents. This study aimed to identify the degree of heavy metals exposure and their potential health risk to local population. The results of hydrochemical analysis showed that Na+ , K+ , and Ca2+ ions are the dominant cations in the groundwater, while HCO3 - , F- and Cl- ions dominate the anionic part of the groundwater. The weathering process was considered the dominant factor to determine the major ionic composition in the study area...
April 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679869/characterization-of-adsorption-and-desorption-of-lawn-herbicide-siduron-in-heavy-metal-contaminated-soils
#2
Rong Jiang, Meie Wang, Weiping Chen
Siduron is a widely used herbicide in urban lawn and has been frequently detected in urban and suburban surface water. However, characteristics of its environmental behavior in soil are seldom reported. The combined pollution of heavy metals, especially for Cu, Pb, Cd, Zn and siduron would be common because of the widely existence of heavy metal pollution in urban soils. In this study, four soils with similar physicochemical properties but different levels of preexisting heavy metals were selected to investigate the adsorption and successive desorption of siduron using batch experiments...
April 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29678227/humoral-and-cell-mediated-immune-responses-to-influenza-vaccination-in-equine-metabolic-syndrome-ems-horses
#3
Sarah Elzinga, Stephanie Reedy, Virginia D Barker, Thomas M Chambers, Amanda A Adams
Obesity is an increasing problem in the equine population with recent reports indicating that the percentage of overweight horses may range anywhere from 20.6-51%. Obesity in horses has been linked to more serious health concerns such as equine metabolic syndrome (EMS). EMS is a serious problem in the equine industry given its defining characteristics of insulin dysregualtion and obesity, as well as the involvement of laminitis. Little research however has been conducted to determine the effects of EMS on routine healthcare of these horses, in particular how they respond to vaccination...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29678074/a-synthesis-of-students-theses-in-the-accredited-hhsi-master-s-programme
#4
Ulla-Mari Kinnunen, Kaija Saranto
Education in Health Informatics (HI) has been a key priority to guarantee knowledge and skills for professionals working in healthcare settings. One of the early academic models to teach HI are the recommendations provided by the International Medical Informatics Association. The paper describes the curriculum developed for master's degrees and the status of a paradigm used in informatics education, as well as research in the health and human services fields. The aim is to synthesise the methodological focuses in students' theses and discuss the future needs for development...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677147/detection-of-anomalous-noise-events-on-low-capacity-acoustic-nodes-for-dynamic-road-traffic-noise-mapping-within-an-hybrid-wasn
#5
Rosa Ma Alsina-Pagès, Francesc Alías, Joan Claudi Socoró, Ferran Orga
One of the main aspects affecting the quality of life of people living in urban and suburban areas is the continuous exposure to high road traffic noise (RTN) levels. Nowadays, thanks to Wireless Acoustic Sensor Networks (WASN) noise in Smart Cities has started to be automatically mapped. To obtain a reliable picture of the RTN, those anomalous noise events (ANE) unrelated to road traffic (sirens, horns, people, etc.) should be removed from the noise map computation by means of an Anomalous Noise Event Detector (ANED)...
April 20, 2018: Sensors
https://www.readbyqxmd.com/read/29676070/analysis-of-peripheral-b-cell-subsets-in-patients-with-allergic-rhinitis
#6
Jing Luo, Huanhuan Guo, Zhuofu Liu, Tao Peng, Xianting Hu, Miaomiao Han, Xiangping Yang, Xuhong Zhou, Huabin Li
PURPOSE: Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic rhinitis (AR) have not been well documented. This study aimed to analyze the characteristics of B cell subsets in the peripheral blood of AR patients. METHODS: Forty-seven AR patients and 54 healthy controls were enrolled in this study, and the B cell subsets in peripheral blood of all subjects were analyzed by flow cytometry...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29676012/further-audiovestibular-characterization-of-dfnb77-caused-by-deleterious-variants-in-loxhd1-and-investigation-into-the-involvement-of-fuchs-corneal-dystrophy
#7
M Wesdorp, V Schreur, A J Beynon, J Oostrik, J M van de Kamp, M W Elting, M-J H van den Boogaard, I Feenstra, R J C Admiraal, H P M Kunst, C B Hoyng, H Kremer, H G Yntema, R J E Pennings, M Schraders
This study focuses on further characterization of the audiovestibular phenotype and on genotype-phenotype correlations of DFNB77, an autosomal recessive type of hearing impairment (HI). DFNB77 is associated with disease-causing variants in LOXHD1, and is genetically and phenotypically highly heterogeneous. Heterozygous deleterious missense variants in LOXHD1 have been associated with late-onset Fuchs corneal dystrophy (FCD). However, up to now screening for FCD of heterozygous carriers in DFNB77 families has not been reported...
April 19, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29675013/development-of-chemically-defined-media-reveals-citrate-as-preferred-carbon-source-for-liberibacter-growth
#8
Maritsa Cruz-Munoz, Joseph R Petrone, Alexa R Cohn, Alam Munoz-Beristain, Nabil Killiny, Jennifer C Drew, Eric W Triplett
Liberibacter crescens is the closest cultured relative of four important uncultured crop pathogens. Candidatus L. asiaticus, L. americanus, and L. africanus are causal agents of citrus greening disease, otherwise known as huanglongling (HLB). Candidatus L. solanacearum is responsible for potato Zebra chip disease. Cultures of L. crescens grow slowly on BM-7 complex medium, while attempts to culture the Ca. Liberibacter pathogens in BM-7 have failed. Developing a defined medium for the growth of L. crescens will be useful in the study of Liberibacter metabolism and will improve the prospects for culturing the Ca ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674753/combining-fluorescence-imaging-with-hi-c-to-study-3d-genome-architecture-of-the-same-single-cell
#9
David Lando, Srinjan Basu, Tim J Stevens, Andy Riddell, Kai J Wohlfahrt, Yang Cao, Wayne Boucher, Martin Leeb, Liam P Atkinson, Steven F Lee, Brian Hendrich, Dave Klenerman, Ernest D Laue
Fluorescence imaging and chromosome conformation capture assays such as Hi-C are key tools for studying genome organization. However, traditionally, they have been carried out independently, making integration of the two types of data difficult to perform. By trapping individual cell nuclei inside a well of a 384-well glass-bottom plate with an agarose pad, we have established a protocol that allows both fluorescence imaging and Hi-C processing to be carried out on the same single cell. The protocol identifies 30,000-100,000 chromosome contacts per single haploid genome in parallel with fluorescence images...
May 2018: Nature Protocols
https://www.readbyqxmd.com/read/29674624/brain-and-spinal-cord-injury-repair-by-implantation-of-human-neural-progenitor-cells-seeded-onto-polymer-scaffolds
#10
Jeong Eun Shin, Kwangsoo Jung, Miri Kim, Kyujin Hwang, Haejin Lee, Il-Sun Kim, Bae Hwan Lee, Il-Shin Lee, Kook In Park
Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29672968/potent-3-hydroxy-2-pyridine-aldoxime-reactivators-of-organophosphate-inhibited-cholinesterases-with-predicted-blood-brain-barrier-penetration
#11
Tamara Zorbaz, Anissa Braïki, Nikola Marakovic, Julien Renou, Eugenio de la Mora, Nikolina Marek Hrvat, Maja Katalinic, Israel Silman, Joel L Sussman, Guillaume Mercey, Catherine Gomez, Romain Mougeot, Belen Perez, Rachid Baati, Florian Nachon, Martin Weik, Ludovic Jean, Kovarik Zrinka, Pierre-Yves Renard
A new series of 3-hydroxy-2-pyridine aldoxime compounds were designed, synthesized and tested in vitro, in silico and ex vivo as reactivators of human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) inhibited by organophosphates (OPs) (e.g., VX, sarin, cyclosarin, tabun and paraoxon). The reactivation rates of three oximes (16, 17, 18) were greater than those of 2-PAM, and comparable to HI-6, two pyridinium aldoximes currently used by the armies of several countries worldwide. The important interactions for a productive orientation of the oxime group within the OP-inhibited enzyme were clarified by molecular modelling studies and by the resolution of the crystal structure of the complex of 17 with Torpedo californica AChE...
April 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29671813/association-of-anthropometric-indices-of-obesity-with-hypertension-in-chinese-elderly-an-analysis-of-age-and-gender-differences
#12
Qian Wang, Lingzhong Xu, Jiajia Li, Long Sun, Wenzhe Qin, Gan Ding, Jing Zhu, Jiao Zhang, Zihang Yu, Su Xie
This study aims to explore the association of anthropometric indices of obesity with hypertension in Chinese elderly and its possible gender and age differences. A total of 7070 adults age 60 or older were interviewed in a cross-sectional study conducted in 2017. Anthropometric indices for each participant were measured by using standard methods of trained doctoral/master students. We performed two binary logistic regression models to examine the association of the nine different anthropometric indices and hypertension by gender...
April 19, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29670587/influenza-viral-vectors-expressing-two-kinds-of-ha-proteins-as-bivalent-vaccine-against-highly-pathogenic-avian-influenza-viruses-of-clade-2-3-4-4-h5-and-h7n9
#13
Jinping Li, Guangyu Hou, Yan Wang, Suchun Wang, Cheng Peng, Xiaohui Yu, Wenming Jiang
The H5 and H7N9 subtypes of highly pathogenic avian influenza viruses (HPAIVs) in China pose a serious challenge to public health and the poultry industry. In this study, a replication competent recombinant influenza A virus of the Í5N1 subtype expressing the H7 HA1 protein from a tri-cistronic NS segment was constructed. A heterologous dimerization domain was used to combine with the truncated NS1 protein of 73 amino acids to increase protein stability. H7 HA1, nuclear export protein coding region, and the truncated NS1 were fused in-frame into a single open reading frame via 2A self-cleaving peptides...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29669733/evolution-of-dnaasei-hypersensitive-sites-in-mhc-regulatory-regions-of-primates
#14
Yabin Jin, Rachel M Gittelman, Yueer Lu, Xiaohui Liu, Ming D Li, Fei Ling, Joshua M Akey
It has been challenged to determine the disease-causing variant(s) for most major histocompatibility complex (MHC) associated diseases. However, it is becoming increasingly clear that regulatory variation is pervasive and a fundamentally important mechanism governing phenotypic diversity and disease susceptibility. We leveraged DNase I data from 136 human cells to characterize the regulatory landscape of the MHC region, including 4867 DNase I hypersensitive sites (DHSs). We identified thousands of regulatory elements that have been gained or lost in the human or chimpanzee genomes since their evolutionary divergence...
April 18, 2018: Genetics
https://www.readbyqxmd.com/read/29669531/assessment-of-an-optimized-manufacturing-process-for-inactivated-quadrivalent-influenza-vaccine-a-phase-iii-randomized-double-blind-safety-and-immunogenicity-study-in-children-and-adults
#15
Carine Claeys, Mamadou Drame, José García-Sicilia, Khalequ Zaman, Alfonso Carmona, Phu My Tran, Mariano Miranda, Federico Martinón-Torres, Franck Thollot, Michael Horn, Tino F Schwarz, Ulrich Behre, José M Merino, Iwona Sadowska-Krawczenko, Henryk Szymański, Peter Schu, Elisabeth Neumeier, Ping Li, Varsha K Jain, Bruce L Innis
BACKGROUND: GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an increased number of finished vaccine doses, while compensating for the change from inactivated trivalent influenza vaccine (IIV3) to IIV4. To confirm the manufacturing changes do not alter the profile of the vaccine, a clinical trial was conducted to compare IIV4 made by the currently licensed process with a vaccine made by the new (investigational) process (IIV4-I)...
April 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29668374/evidence-based-occupational-hearing-screening-ii-validation-of-a-screening-methodology-using-measures-of-functional-hearing-ability
#16
Sigfrid D Soli, Akiko Amano-Kusumoto, Odile Clavier, Jed Wilbur, Kristen Casto, Daniel Freed, Chantal Laroche, Véronique Vaillancourt, Christian Giguère, Wouter A Dreschler, Koenraad S Rhebergen
OBJECTIVE: Validate use of the Extended Speech Intelligibility Index (ESII) for prediction of speech intelligibility in non-stationary real-world noise environments. Define a means of using these predictions for objective occupational hearing screening for hearing-critical public safety and law enforcement jobs. DESIGN: Analyses of predicted and measured speech intelligibility in recordings of real-world noise environments were performed in two studies using speech recognition thresholds (SRTs) and intelligibility measures...
May 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29666554/effect-of-different-pre-analytical-conditions-on-plasma-lactate-concentration
#17
Ivana Rako, Ana Mlinaric, Monika Dozelencic, Gordana Fressl Juros, Dunja Rogic
Introduction: Plasma lactate is a frequently used and important parameter for medical decision making. To setup a pre-analytical algorithm, we aimed to investigate the influence of different test tube additives, aliquoting, ice storage and haemolysis on plasma lactate concentrations for possible sparing critically ill (ICU) patients of additional blood drawing. Materials and methods: In our study (N = 177), lactate concentration and haemolysis index (HI) were measured in aliquoted (AHP) and unaliquoted (HP) Li-heparin, NaF/K3 EDTA and NaF/KOX plasma, centrifuged within 15 minutes after venipuncture, on Cobas c501 analyzer...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29666371/integration-of-human-adipocyte-chromosomal-interactions-with-adipose-gene-expression-prioritizes-obesity-related-genes-from-gwas
#18
David Z Pan, Kristina M Garske, Marcus Alvarez, Yash V Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K Raulerson, Rita M Cantor, Mete Civelek, Craig A Glastonbury, Kerrin S Small, Michael Boehnke, Aldons J Lusis, Janet S Sinsheimer, Karen L Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We find that promoter-interacting elements in human adipocytes are enriched for adipose-related transcription factor motifs, such as PPARG and CEBPB, and contribute to heritability of cis-regulated gene expression...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29665000/increased-killer-b-cells-in-chronic-hcv-infection-may-lead-to-autoimmunity-and-increased-viral-load
#19
Nasren Eiza, Eli Zuckerman, Matthias Carlebach, Tova Rainis, Yair Goldberg, Zahava Vadasz
BACKGROUND: B regulatory (Breg) cells are characterized by various membrane markers, and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi. Their main reported role is to suppress anti-viral and anti-tumor immune responses and hence, they have been dubbed "killer" B cells. In this study, we aim to assess the role of these cells in chronic hepatitis C virus (HCV) infection, and determine if they contribute to the increased viral load and persistence of HCV and its related autoimmunity...
April 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29662163/polymer-physics-predicts-the-effects-of-structural-variants-on-chromatin-architecture
#20
Simona Bianco, Darío G Lupiáñez, Andrea M Chiariello, Carlo Annunziatella, Katerina Kraft, Robert Schöpflin, Lars Wittler, Guillaume Andrey, Martin Vingron, Ana Pombo, Stefan Mundlos, Mario Nicodemi
Structural variants (SVs) can result in changes in gene expression due to abnormal chromatin folding and cause disease. However, the prediction of such effects remains a challenge. Here we present a polymer-physics-based approach (PRISMR) to model 3D chromatin folding and to predict enhancer-promoter contacts. PRISMR predicts higher-order chromatin structure from genome-wide chromosome conformation capture (Hi-C) data. Using the EPHA4 locus as a model, the effects of pathogenic SVs are predicted in silico and compared to Hi-C data generated from mouse limb buds and patient-derived fibroblasts...
April 16, 2018: Nature Genetics
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