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https://www.readbyqxmd.com/read/29333488/dopamine-development-in-the-mouse-orbital-prefrontal-cortex-is-protracted-and-sensitive-to-amphetamine-in-adolescence
#1
Daniel Hoops, Lauren M Reynolds, Jose-Maria Restrepo-Lozano, Cecilia Flores
The prefrontal cortex (PFC) is divided into subregions, including the medial and orbital prefrontal cortices. Dopamine connectivity in the medial PFC (mPFC) continues to be established throughout adolescence as the result of the continuous growth of axons that innervated the nucleus accumbens (NAcc) prior to adolescence. During this period, dopamine axons remain vulnerable to environmental influences, such as drugs used recreationally by humans. The developmental trajectory of the orbital prefrontal dopamine innervation remains almost completely unstudied...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29333487/activation-of-the-medial-prefrontal-cortex-reverses-cognitive-and-respiratory-symptoms-in-a-mouse-model-of-rett-syndrome
#2
C James Howell, Michael P Sceniak, Min Lang, Wenceslas Krakowiecki, Fatimah E Abouelsoud, Saloni U Lad, Heping Yu, David M Katz
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2; Amir et al., 1999), a transcriptional regulatory protein (Klose et al., 2005). Mouse models of RTT (Mecp2 mutants) exhibit excitatory hypoconnectivity in the medial prefrontal cortex (mPFC; Sceniak et al., 2015), a region critical for functions that are abnormal in RTT patients, ranging from learning and memory to regulation of visceral homeostasis (Riga et al...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29331532/high-fat-diet-mediates-anxiolytic-like-behaviors-in-a-time-dependent-manner-through-the-regulation-of-sirt1-in-the-brain
#3
Liu Xu, Shuang Xu, Lifang Lin, Xi Gu, Congcong Fu, Yingying Fang, Xiaowen Li, Xuemin Wang
The consumption of a high-fat diet (HFD) and obesity have been associated not only with metabolic diseases but also with neuropsychiatric diseases, such as depression and anxiety. However, results on the effects of an HFD on anxiety are controversial, since both anxiogenic and anxiolytic effects have been reported. In this study, we evaluated the effects of both short- and long-term intake of an HFD on anxiety-like behaviors. To explore the impact of time on the association between an HFD and anxiety, mice were fed with an HFD for 4 weeks or 12 weeks...
January 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29317484/chemogenetic-excitation-of-accumbens-projecting-infralimbic-cortical-neurons-blocks-toluene-induced-conditioned-place-preference
#4
Wesley N Wayman, John J Woodward
Abuse rates for inhalants among adolescents continue to be high, yet preclinical models for studying mechanisms underlying inhalant abuse remain limited. Our lab has previously shown that, in male rats, an acute binge-like exposure to toluene vapor that mimics human solvent abuse modifies the intrinsic excitability of medial prefrontal cortex (mPFC) pyramidal neurons projecting to the nucleus accumbens (NAc). These changes showed region (infralimbic; IL vs. prelimbic; PRL), layer (shallow; 2/3 vs. deep; 5/6), target (core vs...
January 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29316846/acute-stress-evokes-sexually-dimorphic-stressor-specific-patterns-of-neural-activation-across-multiple-limbic-brain-regions-in-adult-rats
#5
Ankit Sood, Karina Chaudhari, Vidita A Vaidya
Stress enhances the risk for psychiatric disorders such as anxiety and depression. Stress responses vary across sex and may underlie the heightened vulnerability to psychopathology in females. Here, we examined the influence of acute immobilization stress (AIS) and a two-day short-term forced swim stress (FS) on neural activation in multiple cortical and subcortical brain regions, implicated as targets of stress and in the regulation of neuroendocrine stress responses, in male and female rats using Fos as a neural activity marker...
January 10, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29315577/bidirectional-variation-in-glutamate-efflux-in-the-medial-prefrontal-cortex-induced-by-selective-positive-and-negative-allosteric-mglur5-modulators
#6
Sarah N Isherwood, Trevor W Robbins, Jeffrey W Dalley, Anton Pekcec
Dysregulation of prefrontal cortical glutamatergic signalling via NMDA receptor hypofunction has been implicated in cognitive dysfunction and impaired inhibitory control in such neuropsychiatric disorders as schizophrenia, attention deficit hyperactivity disorder and drug addiction. Although NMDA receptors functionally interact with metabotropic glutamate receptor 5 (mGluR5), the consequence of this interaction for glutamate release in the prefrontal cortex (PFC) is unknown. We therefore investigated the effects of positive and negative allosteric mGluR5 modulation on changes in extracellular glutamate efflux in the medial PFC (mPFC) induced by systemic administration of the non-competitive NMDA receptor antagonist dizocilpine (or MK801) in rats...
January 6, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29309799/circuit-based-frameworks-of-depressive-behaviors-the-role-of-reward-circuitry-and-beyond
#7
REVIEW
Daniel Knowland, Byung Kook Lim
Major depressive disorder (MDD) is a common but serious neuropsychiatric affliction that comprises a diverse set of symptoms such as the inability to feel pleasure, lack of motivation, changes in appetite, and cognitive difficulties. Given the patient to patient symptomatic variability in MDD and differing severities of individual symptoms, it is likely that maladaptive changes in distinct brain areas may mediate discrete symptoms in MDD. The advent and recent surge of studies using viral-genetic approaches have allowed for circuit-specific dissection of networks underlying motivational behavior...
January 5, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29309585/role-of-5-ht1a-receptor-stimulation-in-the-medial-prefrontal-cortex-in-the-sustained-antidepressant-effects-of-ketamine
#8
Kenichi Fukumoto, Michihiko Iijima, Takeo Funakoshi, Shigeyuki Chaki
Background: We previously reported that serotonergic transmission plays an important role in antidepressant effects of ketamine. However, detailed mechanisms have not been elucidated. Among the serotonin (5-HT) receptor subtypes, the 5-HT1A receptor in the medial prefrontal cortex (mPFC) has an important role in depression. Here, we investigated the role of the mPFC 5-HT1A receptor and its signaling mechanism in the antidepressant effects of ketamine. Methods: The role of 5-HT1A receptor-mediated signaling mechanism (phosphoinositide-3 kinase (PI3K)/Akt) in the mPFC was examined in the mouse forced swimming test and western blotting...
December 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29308983/why-people-are-always-thinking-about-themselves-medial-prefrontal-cortex-activity-during-rest-primes-self-referential-processing
#9
Meghan L Meyer, Matthew D Lieberman
Humans have a tendency to think about themselves. What generates this self-focus? One clue may come from the observation that the same part of the brain that supports self-reflection-the medial pFC (MPFC/Brodmann's area 10 [BA 10])-also spontaneously engages by default whenever the brain is free from external demands to attention. Here, we test the possibility that the default tendency to engage MPFC/BA 10 primes self-referential thinking. Participants underwent fMRI while alternating between brief periods of rest and experimental tasks in which they thought about their own traits, another person's traits, or another location's traits...
January 8, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29299641/responsibility-modulates-the-neural-correlates-of-regret-during-the-sequential-risk-taking-task
#10
Lin Li, Zhiyuan Liu, Huanghuang Niu, Li Zheng, Xuemei Cheng, Peng Sun, Fanzhi Anita Zhou, Xiuyan Guo
Responsibility is a necessary prerequisite in the experience of regret. The present fMRI study investigated the modulation of responsibility on the neural correlates of regret during a sequential risk-taking task. Participants were asked to open a series of boxes consecutively and decided when to stop. Each box contained a reward, except for one containing a devil to zero participant's gain in the trial. Once participants stopped, both collected gains and missed chances were revealed. We manipulated responsibility by setting two different contexts...
January 3, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29297154/altered-topological-patterns-of-brain-functional-networks-in-crohn-s-disease
#11
Peng Liu, Ru Li, Chunhui Bao, Ying Wei, Yingying Fan, Yanfei Liu, Geliang Wang, Huangan Wu, Wei Qin
Crohn's disease (CD) has been reported to relate with the functional and structural alterations in several local brain regions. However, it remains unknown whether the possible abnormalities of information transmission and integration between brain regions are associated with CD. The purpose of this study was to investigate the topological alterations of brain functional networks and the potential relationships between the neuroimaging findings and CD clinical characteristics. 43 remissive CD patients and 37 matched healthy controls (HCs) were recruited to obtain their resting-state functional magnetic resonance imaging (fMRI) data...
January 3, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29289597/hippocampal-gabaa-antagonism-reverses-the-novel-object-recognition-deficit-in-sub-chronic-phencyclidine-treated-rats
#12
Nichole M Neugebauer, Masanori Miyauchi, Tatsuya Sato, Jun Tadano, Hanife Akal, Hossein Ardehali, Herbert Y Meltzer
BACKGROUND: Abnormalities in prefrontal cortical and hippocampal GABAergic function are postulated to be major causes of the cognitive impairment associated with schizophrenia (CIAS). There are conflicting views on whether diminished or enhanced GABAergic activity contributes to the deficit in short-term novel object recognition (NOR) in the sub-chronic phencyclidine (scPCP) rodent model of CIAS. This study assessed the role of GABAA signaling in the medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC) in NOR in saline (scSAL)- and scPCP-treated rats...
December 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29282124/memory-retrieval-in-addiction-a-role-for-mir-105-mediated-regulation-of-d1-receptors-in-mpfc-neurons-projecting-to-the-basolateral-amygdala
#13
Yanfang Zhao, Junfang Zhang, Hualan Yang, Dongyang Cui, Jiaojiao Song, Qianqian Ma, Wenjie Luan, Bin Lai, Lan Ma, Ming Chen, Ping Zheng
BACKGROUND: Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study of chronic morphine-induced adaptation in the brain and its functional significance is of importance to understand the mechanism of morphine addiction. Previous studies have found a number of chronic morphine-induced adaptive changes at molecular levels in the brain. A study from our lab showed that chronic morphine-induced increases in the expression of D1 receptors at presynaptic terminals coming from other structures to the basolateral amygdala (BLA) played an important role in environmental cue-induced retrieval of morphine withdrawal memory...
December 27, 2017: BMC Biology
https://www.readbyqxmd.com/read/29278697/downregulation-of-5-hydroxytryptamine7-receptor-in-the-medial-prefrontal-cortex-ameliorates-impulsive-actions-in-animal-models-of-schizophrenia
#14
Junhui Liu, Wei Zhang, Jinteng Feng, Min Jia, Guangjian Zhang, Xiaopeng Wen
5-hydroxytryptamine7 (5-HT7) receptors in the medial prefrontal cortex (mPFC) play a critical role in complex cognitive impairment in schizophrenia. The mouse model of schizophrenia was established through the neonatal administration of phencyclidine (nPCP). Recombinant adeno-associated virus-mediated gene knockdown was used to investigate the role of mPFC 5-HT7 receptor in the schizophrenia-like symptoms in mice. Under baseline conditions in the 5-choice serial reaction time task (5-CSRTT), nPCP produced a significant attentional impairment that was exacerbated when mice were tested under LITI...
December 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29275591/-dysfunctional-resting-state-connectivity-of-default-mode-network-in-adolescent-patients-with-first-episode-drug-naive-major-depressive-disorder
#15
S Y Li, Y Zhu, Y L Wang, P P Lü, W B Zuo, F Y Li
Objective: To study resting-state functional connectivity (FC) of default mode network (DMN) in adolescent patients with first-episode drug-naive major depressive disorder (MDD). Methods: We enrolled thirty first-episode and drug-naive adolescent MDD patients and twenty-nine adolescent healthy control (HC) participants in the First Affiliated Hospital of Zhengzhou University. There were no differences in age, sex, and education between the MDD and HC group. Resting-state functional magnetic resonance images (fMRI) was performed...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29260367/larger-volume-and-different-functional-connectivity-of-the-amygdala-in-women-with-premenstrual-syndrome
#16
Demao Deng, Yong Pang, Gaoxiong Duan, Huimei Liu, Hai Liao, Peng Liu, Yanfei Liu, Shasha Li, Wenfu Chen, Danhong Wen, Chunmei Xuan, Min Li
OBJECTIVES: To assess structural and functional changes of the amygdala due to premenstrual syndrome (PMS) using magnetic resonance imaging (MRI). METHODS: Twenty PMS patients and 21 healthy control (HC) subjects underwent a 6-min resting-state fMRI scan during the luteal phase as well as scanning high-resolution T1-weighted images. Subcortical amygdala-related volume and functional connectivity (FC) were estimated between the two groups. Each subject completed a daily record of severity of problems (DRSP) to measure the severity of clinical symptoms...
December 19, 2017: European Radiology
https://www.readbyqxmd.com/read/29259151/hippocampal-prefrontal-theta-gamma-coupling-during-performance-of-a-spatial-working-memory-task
#17
Makoto Tamura, Timothy J Spellman, Andrew M Rosen, Joseph A Gogos, Joshua A Gordon
Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta-slow gamma coupling between the hippocampus and medial prefrontal cortex (mPFC) is augmented in a genetic mouse model of cognitive dysfunction. This increased cross-frequency coupling is observed specifically when the mice successfully perform a spatial working memory task...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29247759/repeated-methamphetamine-and-modafinil-induce-differential-cognitive-effects-and-specific-histone-acetylation-and-dna-methylation-profiles-in-the-mouse-medial-prefrontal-cortex
#18
Betina González, Subramaniam Jayanthi, Natalia Gomez, Oscar V Torres, Máximo H Sosa, Alejandra Bernardi, Francisco J Urbano, Edgar García-Rill, Jean-Lud Cadet, Verónica Bisagno
Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation behind the lasting changes that drugs of abuse and other psychotropic compounds induce in the brain, like the control of gene expression by histones 3 and 4 tails acetylation (H3ac and H4ac) and DNA cytosine methylation (5-mC)...
December 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29247751/performance-of-the-odour-span-task-is-not-impaired-following-inactivations-of-parietal-cortex-in-rats
#19
Gavin A Scott, Nadine K Zabder, Quentin Greba, John G Howland
Working memory (WM) is the ability to temporarily store information for use and manipulation. Working memory is thought to depend on a distributed set of higher cortical areas including the prefrontal and parietal cortex in primates while relatively little research has been conducted in rodents to elucidate the exact role of the parietal cortex (PC) in WM, particularly in relation to the construct of working memory capacity. Previous work in our lab demonstrates that performance of the odour span task (OST), an olfactory incremental delayed nonmatching-to-sample task, relies on the medial prefrontal cortex (mPFC)...
December 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29247260/adolescent-cocaine-exposure-induces-prolonged-synaptic-modifications-in-medial-prefrontal-cortex-of-adult-rats
#20
Wei Zhu, Xuhui Ge, Peng Gao, Min Li, Yun Guan, Xiaowei Guan
Substance used during adolescent period increases the risk of psychiatric disorders in later life, but the underlying neural mechanisms remain unclear. We hypothesize that synaptic remodeling and changes of homeostasis in the medial prefrontal cortex (mPFC) following adolescent cocaine exposure may last for a long time, and these modifications may contribute to behavioral deficiencies in adulthood. To address this hypothesis, rats were exposed to cocaine hydrochloride from postnatal day 28 (P28) to P42. When reared to adulthood, rats were subjected to behavioral tests...
December 15, 2017: Brain Structure & Function
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