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https://www.readbyqxmd.com/read/28719229/experiences-using-pre-exposure-prophylaxis-for-safer-conception-among-hiv-serodiscordant-heterosexual-couples-in-the-united-states
#1
Angela R Bazzi, Ashley A Leech, Dea L Biancarelli, Meg Sullivan, Mari-Lynn Drainoni
Antiretroviral pre-exposure prophylaxis (PrEP) is a promising HIV prevention strategy for HIV serodiscordant couples (HIV-infected male, uninfected female) seeking safer conception. However, most research on PrEP for safer conception has focused on couples in sub-Saharan Africa; little is known about the perspectives or experiences of heterosexual couples in the United States. We conducted qualitative interviews with six couples (six women and five of their male partners) receiving PrEP for conception services at an urban safety net hospital in the US Northeast...
July 18, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28718498/assessing-hiv-acquisition-risks-among-men-who-have-sex-with-men-in-the-united-states-of-america
#2
Ram K Shrestha, Stephanie L Sansom, David W Purcell
Men who have sex with men (MSM) can reduce their risk of acquiring human immunodeficiency virus (HIV) by using various prevention strategies and by understanding the effectiveness of each option over the short- and long-term. Strategies examined were: circumcision; insertive anal sex only; consistent, 100% self-reported condom use; and pre-exposure prophylaxis (PrEP). PrEP efficacy was based on three levels of adherence. The cumulative HIV acquisition risk among MSM over periods of 1 year and 10 years were estimated with and without single and combinations of prevention strategies...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28715159/alcohol-antiretroviral-interactive-toxicity-beliefs-as-a-potential-barrier-to-hiv-pre-exposure-prophylaxis-among-men-who-have-sex-with-men
#3
Seth C Kalichman, Lisa Eaton
INTRODUCTION: Pre-exposure prophylaxis (PrEP) offers as much as 90% protection against HIV transmission. However, the effectiveness of PrEP depends on uptake and adherence to even intermittent dosing. Along with intoxication leading to unintentional non-adherence, believing that alcohol mixed with pharmaceuticals is harmful (i.e., interactive toxicity beliefs) may lead to poor uptake and intentional non-adherence. METHODS: HIV-negative sexually active men who have sex with men (N = 272) at a large Gay Pride event in Atlanta, GA, completed anonymous surveys of demographic characteristics, sexual behaviour, alcohol use and PrEP-related alcohol interactive toxicity beliefs...
July 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28710996/the-fourth-generation-alere-tm-hiv-combo-rapid-test-improves-detection-of-acute-infection-in-mtn-003-voice-samples
#4
Edward Livant, Amy Heaps, Cliff Kelly, Rashika Maharaj, Natasha Samsunder, Lindiwe Nhlangulela, Patrick Karugaba, Ravindre Panchia, Jeanne Marrazzo, Zvavahera Mike Chirenje, Urvi M Parikh
BACKGROUND: Early and accurate detection of HIV is crucial when using pre-exposure prophylaxis (PrEP) for HIV prevention to avoid PrEP initiation in acutely infected individuals and to minimize the risk of drug resistance in individuals with breakthrough infection. OBJECTIVE: To determine if fourth-generation antigen/antibody (Ag/Ab) rapid diagnostic tests (RDT) would have detected HIV infection earlier than the third-generation RDT used in MTN-003 (VOICE). STUDY DESIGN: 5029 VOICE participants were evaluated with third-generation Alere Determine™ HIV-1/2, OraQuick ADVANCE(®) Rapid HIV-1/2, Uni-Gold™ Recombigen(®) HIV-1/2 and Bio-Rad GS HIV-1/2+O EIA; and fourth-generation Alere Determine™ HIV-1/2 Ag/Ab Combo, Conformité Européene (CE)-Marked Alere™ HIV Combo and Bio-Rad HIV Combo Ag/Ab EIA...
June 29, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28709753/leveraging-social-media-to-explore-black-women-s-perspectives-on-hiv-pre-exposure-prophylaxis
#5
Bianca S Hill, Viraj V Patel, Lorlette J Haughton, Oni J Blackstock
No abstract text is available yet for this article.
June 23, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28708847/attitudes-and-perceptions-towards-novel-objective-measures-of-arv-based-vaginal-ring-use-results-from-a-global-stakeholder-survey
#6
Randy M Stalter, Jenae Tharaldson, Derek H Owen, Eunice Okumu, Thomas Moench, Natasha Mack, Elizabeth E Tolley, Kathleen M MacQueen
Results of recent microbicide and pre-exposure prophylaxis clinical trials have shown adherence to be a significant challenge with new HIV prevention technologies. As the vaginal ring containing dapivirine moves into two open label follow-on studies (HOPE/MTN-025 and DREAM) and other antiretroviral-based and multi-purpose prevention technology ring products advance through the development pipeline, there is a need for more accurate and reliable measures of adherence to microbicide ring products. We previously conducted a comprehensive landscape analysis to identify new technologies that could be applied to adherence measurement of vaginal rings containing antiretrovirals...
2017: PloS One
https://www.readbyqxmd.com/read/28708811/challenges-in-translating-prep-interest-into-uptake-in-an-observational-study-of-young-black-msm
#7
Charlotte-Paige Rolle, Eli S Rosenberg, Aaron J Siegler, Travis H Sanchez, Nicole Luisi, Kevin Weiss, Scott Cutro, Carlos Del Rio, Patrick S Sullivan, Colleen F Kelley
BACKGROUND: HIV incidence among US young, black MSM (YBMSM) is high, and structural barriers (e.g. lack of health insurance) may limit access to Pre-Exposure Prophylaxis (PrEP). Research studies conducted with YBMSM must ensure access to the best available HIV prevention methods, including PrEP. METHODS: We implemented an optional, non-incentivized PrEP program in addition to standard HIV prevention services in a prospective, observational cohort of HIV-negative YBMSM in Atlanta, GA...
July 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28707025/interest-in-long-acting-injectable-prep-in-a-cohort-of-men-who-have-sex-with-men-in-china
#8
Kathrine Meyers, Yumeng Wu, Haoyu Qian, Theodorus Sandfort, Xiaojie Huang, Junjie Xu, Jing Zhang, Wei Xia, David Glidden, Hao Wu, Hong Shang
Long-acting injectable (LAI) formulations of antiretrovirals (ARVs) as pre-exposure prophylaxis (PrEP) could be an attractive alternative for men who have sex with men (MSM) who are interested in ARV-based biomedical prevention but will not use a daily pill. This study investigated interest in LAI-PrEP in a cohort of MSM in China and characterized how MSM willing to use only injectable PrEP differed from MSM who would use PrEP regardless of modality or not at all. Demographic, behavioral, and risk perception measures were collected and associations investigated...
July 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28705153/a-randomized-clinical-pharmacokinetic-trial-of-tenofovir-in-blood-plasma-and-urine-in-adults-with-perfect-moderate-and-low-prep-adherence-the-target-study
#9
Tim R Cressey, Oraphan Siriprakaisil, Virat Klinbuayaem, Justice Quame-Amaglo, Rachel W Kubiak, Pra-Ornsuda Sukrakanchana, Kanchana Than-In-At, Jared Baeten, Wasna Sirirungsi, Ratchada Cressey, Paul K Drain
BACKGROUND: Tenofovir disoproxil fumarate (TDF) is key component of pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV, but existing tools to monitor drug adherence are often inaccurate. Detection of tenofovir (TFV) in accessible biological samples, such as fingerprick blood, urine or oral fluid samples could be a novel objective measure of recent TDF adherence. To measure TFV concentrations associated with different levels of TDF adherence, we designed a randomized clinical trial to assess the blood, urine and oral fluid concentrations of TFV in adults with perfect, moderate and low drug adherence...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28695388/measuring-acceptability-and-preferences-for-implementation-of-pre-exposure-prophylaxis-prep-using-conjoint-analysis-an-application-to-primary-hiv-prevention-among-high-risk-drug-users
#10
Roman Shrestha, Pramila Karki, Frederick L Altice, Oleksandr Dubov, Liana Fraenkel, Tania Huedo-Medina, Michael Copenhaver
Although people who use drugs (PWUD) are one of the key risk populations who could benefit from the use of pre-exposure prophylaxis (PrEP), to date, little attention has been given to incorporating PrEP into HIV prevention approaches targeting this underserved group. This study investigated the acceptability of PrEP based on a number of known PrEP attributes among high-risk PWUD in a drug treatment setting. A total of 400 HIV-negative PWUD, who reported drug- and/or sex-related risk behaviors were recruited from a methadone clinic to complete a stated preference (full-profile conjoint) survey...
July 10, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28692542/the-effect-of-oral-pre-exposure-prophylaxis-on-the-progression-of-hiv-1-seroconversion
#11
Deborah Donnell, Eric Ramos, Connie Celum, Jared Baeten, Joan Dragavon, Jordan Tappero, Jairam R Lingappa, Allan Ronald, Kenneth Fife, Robert W Coombs
OBJECTIVE: To investigate whether oral pre-exposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1 infection. DESIGN: Retrospective testing of the timing of Fiebig stage HIV-1 seroconversion in the Partners PrEP Study, a randomized placebo-controlled clinical trial of PrEP conducted in Kenya and Uganda. METHODS: Specimens from 138 seroconverters were collected every 3 months and when HIV-1 infection was suspected based on monthly rapid HIV-1 tests...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692536/asymptomatic-anorectal-chlamydia-trachomatis-and-neisseria-gonorrhoeae-infections-are-associated-with-systemic-cd8-t-cell-activation
#12
Vinicius A Vieira, Vivian I Avelino-Silva, Natalia B Cerqueira, Dayane A Costa, Priscilla R Costa, Ricardo P Vasconcelos, Valdez R Madruga, Ronaldo Ismério Moreira, Brenda Hoagland, Valdiléa G Veloso, Beatriz Grinsztejn, Esper G Kallás
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) has been established as a pivotal strategy in HIV prevention. However, bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), are also highly prevalent. Although the presence of STI-related mucosal lesions is a known risk factor for HIV acquisition, the potential increase in risk associated with asymptomatic STIs is not completely understood. Recent data demonstrated higher T cell activation is a risk factor for sexually acquired HIV-1 infection...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692209/the-science-of-durban-aids-2016
#13
Chris Beyrer, Olive Shisana, Stefan D Baral, Koleka Milsana, Kenneth H Mayer, Anton Pozniak, Bruce D Walker, Souleman Mboup, Annette H Sohn, David Serwadda, Helen Rees, Sergii Dvoriak, Mitchell Warren, Safiatou Thiam, Wafaa M El-Sadr, Xavier Hospital, Owen Ryan, Nicolas Thomson, Linda-Gail Bekker
INTRODUCTION: The science presented at the 21st International AIDS Conference in Durban, South Africa, in July 2016, addressed the state of the field across basic, clinical, prevention, law and policy and implementation science. METHODS AND RESULTS: The AIDS response has seen remarkable achievements in scientific advances, in translation of those advances into prevention, treatment and care for affected individuals and communities, and in large scale implementation - reaching 18 million people with antiviral therapy by mid-year 2016...
June 30, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691439/awareness-and-willingness-to-use-hiv-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#14
Siyan Yi, Sovannary Tuot, Grace W Mwai, Chanrith Ngin, Kolab Chhim, Khoundyla Pal, Ewemade Igbinedion, Paula Holland, Sok Chamreun Choub, Gitau Mburu
INTRODUCTION: To facilitate provision of pre-exposure prophylaxis (PrEP) in low- and middle-income countries (LMIC), a better understanding of potential demand and user preferences is required. This review assessed awareness and willingness to use oral PrEP among men who have sex with men (MSM) in LMIC. METHODS: Electronic literature search of Cochrane library, Embase, PubMed, PsychINFO, CINHAL, Web of Science, and Google Scholar was conducted between July and September 2016...
June 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691435/clinical-and-public-health-implications-of-acute-and-early-hiv-detection-and-treatment-a-scoping-review
#15
Sarah E Rutstein, Jintanat Ananworanich, Sarah Fidler, Cheryl Johnson, Eduard J Sanders, Omar Sued, Asier Saez-Cirion, Christopher D Pilcher, Christophe Fraser, Myron S Cohen, Marco Vitoria, Meg Doherty, Joseph D Tucker
INTRODUCTION: The unchanged global HIV incidence may be related to ignoring acute HIV infection (AHI). This scoping review examines diagnostic, clinical, and public health implications of identifying and treating persons with AHI. METHODS: We searched PubMed, in addition to hand-review of key journals identifying research pertaining to AHI detection and treatment. We focused on the relative contribution of AHI to transmission and the diagnostic, clinical, and public health implications...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28688782/a-single-center-open-label-study-of-intradermal-administration-of-an-inactivated-purified-chick-embryo-cell-culture-rabies-virus-vaccine-in-adults
#16
Sergio Recuenco, Eli Warnock, Modupe O V Osinubi, Charles E Rupprecht
In the USA, rabies vaccines (RVs) are licensed for intramuscular (IM) use only, although RVs are licensed for use by the intradermal (ID) route in many other countries. Recent limitations in supplies of RV in the USA reopened discussions on the more efficient use of available biologics, including utilization of more stringent risk assessments, and potential ID RV administration. A clinical trial was designed to compare the immunogenic and adverse effects of a purified chicken embryo cell (PCEC) RV administered ID or IM...
July 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28684224/a-multicomponent-approach-to-evaluating-a-pre-exposure-prophylaxis-prep-implementation-program-in-five-agencies-in-new-york
#17
Donna Parisi, Barbara Warren, ShuYin John Leung, Tugba Akkaya-Hocagil, Qin Qin, Ingrid Hahn, Lyn Stevens
Research has shown that pre-exposure prophylaxis (PrEP) is effective for preventing HIV infection. We developed the Targeted PrEP Implementation Program (TPIP), an 18-month project that involved five statewide agencies, to assess the extent to which PrEP could be implemented in "real world" clinical settings. The target population was men who have sex with men at high risk for HIV infection. Data were collected from a variety of sources. Implementing PrEP statewide required facilitating provider capacity, developing resources, and identifying/addressing potential barriers...
June 16, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28683600/fuckbuddy-partnerships-among-men-who-have-sex-with-men-a-marker-of-sexually-transmitted-infection-risk
#18
Vincent J Cornelisse, Christopher K Fairley, Tiffany Phillips, Sandra Walker, Eric Pf Chow
'Fuckbuddies' are a type of regular sexual partner with whom men have ongoing sexual contact, generally in the absence of romantic attachment. We surveyed 989 men who have sex with men (MSM) at the Melbourne Sexual Health Centre, Australia, with the aim of determining the frequency of 'fuckbuddy' partnerships among sexual health clinic attendees and assessing their sexual risk. The majority (60%) of 1139 regular partnerships were described as 'fuckbuddies'. Most MSM (63%) with a 'fuckbuddy' had multiple 'fuckbuddies'...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28673201/health-and-budget-impact-of-combined-hiv-prevention-first-results-of-the-belhivprev-model
#19
Sebastian Vermeersch, Steven Callens, Stéphane De Wit, Jean-Christophe Goffard, Marie Laga, Dominique Van Beckhoven, Lieven Annemans
OBJECTIVES: We developed a pragmatic modelling approach to estimate the impact of treatment as prevention (TasP); outreach testing strategies; and pre-exposure prophylaxis (PrEP) on the epidemiology of HIV and its associated pharmaceutical expenses. METHODS: Our model estimates the incremental health (in terms of new HIV diagnoses) and budget impact of two prevention scenarios (outreach+TasP and outreach+TasP+PrEP) against a 'no additional prevention' scenario. Model parameters were estimated from reported Belgian epidemiology and literature data...
July 3, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28666918/urinary-tract-infection-after-retrograde-urethrogram-in-children-a-multicenter-study
#20
Neha R Malhotra, Jared R Green, Cynthia K Rigsby, Jane L Holl, Earl Y Cheng, Emilie K Johnson
INTRODUCTION: The risk of post-procedural urinary tract infection (ppUTI) after retrograde urethrogram (RUG) has not been well quantified. Prophylactic antibiotics may reduce the risk, but must be weighed against the risks of antibiotic resistance. Prior research has shown that this risk is variable after voiding cystourethrogram (0-42% reported ppUTI rate) and appears to be low after urodynamics (0-4.8%) but this risk has not been well documented for patients undergoing RUG. OBJECTIVE: We aimed to (1) describe the rate of ppUTI after RUG, and (2) examine factors associated with use of antibiotics at the time of RUG...
June 17, 2017: Journal of Pediatric Urology
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