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https://www.readbyqxmd.com/read/29168695/tenofovir-disoproxil-fumarate-as-pre-exposure-prophylaxis-for-hiv-prevention-in-women-with-osteoporosis-a-case-report-and-review-of-the-literature
#1
Rupa R Patel, Rachel Presti, Laura C Harrison, William G Powderly, Philip A Chan
Pre-exposure prophylaxis (PrEP), using tenofovir disoproxil fumarate (TDF), can effectively prevent HIV acquisition. However, TDF can cause changes in bone mineral density (BMD). There is little information on the use of PrEP among patients with bone disease. We present a case report of a female with pre-existing osteoporosis who was prescribed PrEP. Over the course of nine months of consistent PrEP use, verified by dried blood spot testing, we report a lack of BMD changes on serial dual-emission x-ray absorptiometry scans in this patient...
November 23, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/29166777/tenofovir-disoproxil-fumarate-emtricitabine-fits-for-all-as-appropriate-hiv-1-preexposure-prophylaxis
#2
Lucia Taramasso, Nicolò Riccardi, Filippo Del Puente, Bianca Bruzzone, Diego Ripamonti, Beatrice D'ambrosio, Claudio Viscoli, Antonio Di Biagio
Pre-exposure prophylaxis (PrEP) with TDF/FTC significantly reduces the risk for HIV-1 transmission, but, to date, nobody knows if PrEP can still be useful in case of viruses harboring resistances to TDF/FTC or if alternative antiretroviral drugs might be rather proposed in selected cases. We promote the debate by describing a case of an acute infection with multi-resistant HIV that occurred in a young girl who started a relationship with a HIV-infected partner who had a known multi-resistant HIV.
November 22, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29166481/-prep-forum-an-on-line-debate-on-pre-exposure-prophylaxis-in-brazil
#3
Artur Acelino Francisco Luz Nunes Queiroz, Alvaro Francisco Lopes de Sousa
This study aimed to identify health-promoting contents focused on HIV/Aids prevention in messages posted in a Facebook group for debates on the use of pre-exposure prophylaxis (PrEP). This was a prospective observational study using systematic non-participant observation. From July 2015 to June 2016, all the posts in the group were catalogued and formed a corpus. Everything was processed in IRaMuTeQ and analyzed by descending hierarchical classification. The collected data were grouped in three classes: (1) HIV/Aids prevention: discussing prophylaxis, treatment, target public, and side effects; (2) universal access to PrEP in Brazil: discussing government responsibilities; (3) on-line purchase of truvada: exposing a situation of vulnerability...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29162727/measuring-and-understanding-the-attitudes-of-australian-gay-and-bisexual-men-towards-biomedical-hiv-prevention-using-cross-sectional-data-and-factor-analyses
#4
Anna L Wilkinson, Bridget L Draper, Alisa E Pedrana, Jason Asselin, Martin Holt, Margaret E Hellard, Mark Stoove
INTRODUCTION: Contemporary responses to HIV embrace biomedical prevention, particularly treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP). However, large-scale implementation of biomedical prevention should be ideally preceded by assessments of their community acceptability. We aimed to understand contemporary attitudes of gay and bisexual men (GBM) in Australia towards biomedical-based HIV prevention and propose a framework for their measurement and ongoing monitoring...
November 21, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29161256/hiv-pre-exposure-prophylaxis-and-early-antiretroviral-treatment-among-female-sex-workers-in-south-africa-results-from-a-prospective-observational-demonstration-project
#5
Robyn Eakle, Gabriela B Gomez, Niven Naicker, Rutendo Bothma, Judie Mbogua, Maria A Cabrera Escobar, Elaine Saayman, Michelle Moorhouse, W D Francois Venter, Helen Rees
BACKGROUND: Operational research is required to design delivery of pre-exposure prophylaxis (PrEP) and early antiretroviral treatment (ART). This paper presents the primary analysis of programmatic data, as well as demographic, behavioural, and clinical data, from the TAPS Demonstration Project, which offered both interventions to female sex workers (FSWs) at 2 urban clinic sites in South Africa. METHODS AND FINDINGS: The TAPS study was conducted between 30 March 2015 and 30 June 2017, with the enrolment period ending on 31 July 2016...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29159593/high-burden-of-hiv-syphilis-and-hsv-2-and-factors-associated-with-hiv-infection-among-female-sex-workers-in-tanzania-implications-for-early-treatment-of-hiv-and-pre-exposure-prophylaxis-prep
#6
Lung Vu, Kavita Misra
This paper estimates population-based prevalence of HIV, syphilis, HSV-2 and factors influencing HIV infection using a national sample of 1914 female sex workers (FSWs) in 7 regions in Tanzania. Additionally, HIV incidence was estimated by comparing biological HIV results with self-reported HIV status. The average HIV prevalence among FSWs in all 7 regions was 28%, ranging from 14% in Tabora to 38% in Shinyanga. HIV incidence was found to be 13 per 100 person-years. Syphilis prevalence was 8% with significantly higher burden found in Iringa (11%), Mbeya (13%), and Shinyanga (12%)...
November 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29151200/a-closer-look-at-racism-and-heterosexism-in-medical-students-clinical-decision-making-related-to-hiv-pre-exposure-prophylaxis-prep-implications-for-prep-education
#7
Sarah K Calabrese, Valerie A Earnshaw, Douglas S Krakower, Kristen Underhill, Wilson Vincent, Manya Magnus, Nathan B Hansen, Trace S Kershaw, Kenneth H Mayer, Joseph R Betancourt, John F Dovidio
Social biases among healthcare providers could limit PrEP access. In this survey study of 115 US medical students, we examined associations between biases (racism and heterosexism) and PrEP clinical decision-making and explored prior PrEP education as a potential buffer. After viewing a vignette about a PrEP-seeking MSM patient, participants reported anticipated patient behavior (condomless sex, extra-relational sex, and adherence), intention to prescribe PrEP to the patient, biases, and background characteristics...
November 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29148839/sexual-risk-behaviors-and-perceptions-of-men-who-go-to-gay-sex-parties-in-new-york-city-comparisons-between-three-hiv-groups
#8
Étienne Meunier, Karolynn Siegel
Men who have sex with men (MSM) who attend group-sex events often engage in risky sexual behaviors that contribute to the high human immunodeficiency virus (HIV) incidence among this population. We conducted an online survey with 211 New York City MSM who attended sex parties in the prior year and asked them to describe their behaviors and perceptions of risk. We compared responses from HIV-positive-undetectable men (n = 36), HIV-negative men on pre-exposure prophylaxis (PrEP; n = 62), and HIV-negative men never on PrEP (n = 113)...
November 17, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29147810/acceptability-of-a-tenofovir-disoproxil-fumarate-vaginal-ring-for-hiv-prevention-among-women-in-new-york-city
#9
Dana Watnick, Marla J Keller, Kimberly Stein, Laurie J Bauman
Vaginal rings for pre-exposure prophylaxis are a female-initiated HIV prevention method that does not require daily or coitally-dependent dosing. As part of a randomized placebo-controlled trial of a tenofovir disoproxil fumarate intravaginal ring, we assessed product acceptability through in-depth interviews with 18 women during and after 14 days of continuous use. Women reported that the ring was comfortable with few side effects, regardless of experimental arm. However, interest in future use by this cohort was modest for several reasons including: low self-perceived HIV risk; concern that use implied promiscuity; potential for interference with relationship formation and trust; concern for interference with menstruation and cleanliness; and worries about partners' acceptability and sexual pleasure...
November 16, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29143163/sex-prep-and-stigma-experiences-with-hiv-pre-exposure-prophylaxis-among-new-york-city-msm-participating-in-the-hptn-067-adapt-study
#10
Julie Franks, Yael Hirsch-Moverman, Avelino S Loquere, K Rivet Amico, Robert M Grant, Bonnie J Dye, Yan Rivera, Robert Gamboa, Sharon B Mannheimer
The HPTN 067/Alternative Dosing to Augment Pre-Exposure Prophylaxis Pill Taking (ADAPT) study evaluated daily and non-daily dosing schedules for oral pre-exposure prophylaxis (PrEP) to prevent HIV. A qualitative sub-study including focus groups and in-depth interviews was conducted among men who have sex with men participating in New York City to understand their experience with PrEP and study dosing schedules. The 37 sub-study participants were 68% black, 11% white, and 8% Asian; 27% were of Hispanic/Latino ethnicity...
November 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29140871/hiv-prevalence-and-associated-risk-factors-among-men-who-have-sex-with-men-in-dar-es-salaam-tanzania
#11
Elia John Mmbaga, Kåre Moen, Germana Henry Leyna, Rose Mpembeni, Melkizedeck Thomas Leshabari
INTRODUCTION: Limited studies and differential risk behaviours among men who have sex with men(MSM) in Africa calls for population specific studies. We present results from the largest integrated bio-behavioural survey among MSM in Africa to inform programming. METHODS: This was a cross-sectional study utilizing respondent driven sampling to recruit MSM aged 18 and above. Data on socio-demographic characteristics and HIV-related risks were collected and all participants were tested for HIV, Herpes Simplex Virus Type-2 (HSV-2), Hepatitis-B Virus (HBV) and Syphilis...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29138982/characterizing-the-hiv-prevention-and-care-continua-in-a-sample-of-transgender-youth-in-the-u-s
#12
Sari L Reisner, Laura Jadwin-Cakmak, Jaclyn M White Hughto, Miguel Martinez, Liz Salomon, Gary W Harper
In the U.S., transgender and other gender minority (TG) youth are an at-risk group understudied in HIV prevention and treatment. This study sought to characterize the HIV prevention and care continua in a diverse sample of 181 sexually-active TG ages 16-24 years (mean age = 20.7 years; 76.8% trans feminine; 69.1% youth of color) recruited July-December 2015 in 14 U.S. cities. Overall, 30.9% reported living with HIV, of which 71.4% were on antiretroviral therapy (ART) and 55.0% were medication adherent; 65...
November 14, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29136745/-willingness-and-influencing-factors-of-using-pre-exposure-prophylaxis-among-301-men-have-sex-with-men-in-wuhan-city-2015
#13
P Y Xie, X Wang, P L Liu, X D Tan, W Zhou
Objective: To understand willingness and influencing factors of using pre-exposure prophylaxis (Pr-EP) among men who have sex with men (MSM). Methods: Snow ball sampling was employed to recruit MSM in the social spaces (like bars and bathrooms) with focused activities by MSM and internet (QQ and Wechat) in Wuhan between August and November, 2015. 304 MSM were considered eligible when they were self-identified MSM and has had sex with men in the previous 12 months, over the age of 18 and have full civil liability...
November 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29135656/frequency-of-monitoring-kidney-function-in-hiv-uninfected-persons-using-daily-oral-tenofovir-disoproxil-fumarate-pre-exposure-prophylaxis
#14
Kenneth K Mugwanya, Jared M Baeten, Christina Wyatt, Nelly R Mugo, Connie L Celum, Allan Ronald, John Kiarie, Elly Katabira, Renee Heffron
BACKGROUND: Wide-scale implementation of oral tenofovir-based pre-exposure prophylaxis (PrEP) for HIV prevention is now policy in many settings. However, the optimal frequency for monitoring kidney function remains uncertain. We investigated the impact of 6-monthly compared to 3-monthly creatinine clearance (CrCl) monitoring on the identification of moderate kidney dysfunction, defined as CrCl <60 mL/min. METHODS: Data were from two prospective daily oral PrEP studies in Kenya and Uganda: the Partners PrEP Study, a randomized safety and efficacy trial of PrEP that conducted 3-monthly CrCl monitoring (n=4404) and the Partners Demonstration Project (n=954), an open-label delivery study of PrEP that used 6-monthly monitoring...
November 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135651/comparison-of-the-pharmacokinetics-and-pharmacodynamics-of-single-dose-tenofovir-vaginal-film-and-gel-formulation-fame-05
#15
Jennifer A Robinson, Mark A Marzinke, Edward J Fuchs, Rahul P Bakshi, Hans M L Spiegel, Jenell S Coleman, Lisa C Rohan, Craig W Hendrix
OBJECTIVE: While pre-exposure prophylaxis with oral tenofovir (TFV) disoproxil fumarate/emtricitabine reduces HIV acquisition rates, poor adherence to and acceptability of daily vaginal gels has led to development of vaginal film formulations to improve adherence and, potentially, enable episodic use. STUDY DESIGN: In this two-arm, cross-over study of a fast-dissolving tenofovir film (40 mg) compared to a previously studied semisolid tenofovir 1% gel (40 mg), 10 healthy women received a single vaginal dose of each study product...
November 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135306/a-calculation-tool-and-process-to-pre-position-pharmaceuticals-for-anthrax-post-exposure-prophylaxis
#16
Gary D Peksa, Michael J Robbins, Alexis R Beyer, Elisabeth K Weber, Keneatha Johnson
Anthrax, caused by Bacillus anthracis, is considered a severe bioterrorism threat because of its high mortality rate. The Chicago Healthcare System Coalition for Preparedness and Response (CHSCPR) aims to pre-position antibiotic medical countermeasures (MCMs) at healthcare facilities in order to provide on-site anthrax post-exposure prophylaxis. Pharmacists proposed moving toward a new process that involved the development of a standardized calculation methodology for acquiring supply drugs. This was an interventional quality improvement project aimed at optimizing inventory, acquisition, and distribution of antibiotic MCMs for anthrax post-exposure prophylaxis at Chicago hospitals for hospital personnel, associated first responders, and their families...
November 14, 2017: Health Security
https://www.readbyqxmd.com/read/29132993/re-evaluating-the-effect-of-favipiravir-treatment-on-rabies-virus-infection
#17
Ashley C Banyard, Karen L Mansfield, Guanghui Wu, David Selden, Leigh Thorne, Colin Birch, Penelope Koraka, Albert D M E Osterhaus, Anthony R Fooks
There is no antiviral treatment available once clinical disease following rabies virus infection has initiated. Considered a neglected tropical disease, >60,000 human rabies deaths are estimated each year despite the availability of pre- and post-exposure prophylaxis for pre-immunisation or administration following a potential exposure before the onset of clinical disease. Such post-exposure treatments include administration of rabies immunoglobulin (RIG) and vaccination at a distant site to prime a humoral immune response...
November 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29132291/hiv-prevention-needs-for-men-who-have-sex-with-men-in-swaziland
#18
Bhekie Sithole
Men who have sex with men (MSM) have a high HIV burden and also often face multiple other challenges accessing HIV services, including legal and social issues. Although Swaziland recently started responding with interventions for MSM, significant gaps still exist both in information and programming. This study aimed to explore the HIV prevention needs of MSM in Swaziland, including factors elevating their risks and vulnerabilities to HIV infection; to find out what HIV prevention strategies exist; and to determine how best to meet the prevention needs of MSM...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29127535/predictors-of-hiv-testing-and-their-influence-on-prep-acceptance-in-men-who-have-sex-with-men-a-cross-sectional-study
#19
Tsz Ho Kwan, Shui Shan Lee
HIV testing is the gateway to biomedical means of prevention and treatment. Identifying predictors of HIV testing is important to inform future preventive interventions. Of 444 men who have sex with men without known HIV infection enrolled in a study in Hong Kong, 64% had ever been HIV-tested. Testers were generally older, better educated, had a higher monthly income, and more likely self-identified as gay. Testers often used Internet and frequented saunas for sex networking, compared with non-testers attending bars, massage centres and public toilets...
November 10, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29119473/preference-of-oral-tenofovir-disoproxil-fumarate-emtricitabine-versus-rectal-tenofovir-reduced-glycerin-1-gel-regimens-for-hiv-prevention-among-cisgender-men-and-transgender-women-who-engage-in-receptive-anal-intercourse-with-men
#20
Alex Carballo-Diéguez, Rebecca Giguere, Curtis Dolezal, Cheng-Shiun Leu, Iván C Balán, William Brown, Christine Rael, Barbra A Richardson, Jeanna M Piper, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Liu, Kenneth H Mayer, Carmen D Zorrilla, Javier R Lama, Ian McGowan, Ross D Cranston
Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens...
November 8, 2017: AIDS and Behavior
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