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Myoinositol and infertility

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https://www.readbyqxmd.com/read/27882049/different-effects-of-myoinositol-plus-folic-acid-versus-combined-oral-treatment-on-androgen-levels-in-pcos-women
#1
Ali Cenk Ozay, Ozlen Emekci Ozay, Recep Emre Okyay, Erkan Cagliyan, Tuncay Kume, Bulent Gulekli
Recently, myoinositol (myo-ins) and folic acid combination has gained an important role for treating Polycystic Ovary Syndrome (PCOS), in addition to combined oral contraceptives (COC). We aimed to examine myo-ins effects on anti-Mullerian hormone (AMH) levels and compare them with those ones obtained administering COC. In this prospective study, 137 PCOS patients, diagnosed according to Rotterdam criteria and admitted to the Reproductive Endocrinology and Infertility Outpatient Clinic at Dokuz Eylul University (Izmir, Turkey), were included...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27752262/effect-of-myoinositol-and-antioxidants-on-sperm-quality-in-men-with-metabolic-syndrome
#2
Mario Montanino Oliva, Elisa Minutolo, Assunta Lippa, Paola Iaconianni, Alberto Vaiarelli
This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27642297/myoinositol-as-a-safe-and-alternative-approach-in-the-treatment-of-infertile-pcos-women-a-german-observational-study
#3
Pedro-Antonio Regidor, Adolf Eduard Schindler
The use of 2 × 2000 mg myoinositol + 2 × 200 μg folic acid per day is a safe and promising tool in the effective improvement of symptoms and infertility for patients with a polycystic ovary syndrome (PCOS). Using a questionnaire an observational study was performed under German gynecologists to collect data on ovulation and pregnancy rates in PCOS patients with infertility. In this observational study, 3602 infertile women used myoinositol and folic acid between 2 and 3 months in a dosage of 2 × 2000 mg myoinositol + 2 × 200 μg folic acid per day...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27635136/prospective-randomized-study-on-the-influence-of-myoinositol-in-pcos-women-undergoing-ivf-in-the-improvement-of-oocyte-quality-fertilization-rate-and-embryo-quality
#4
Bernd Lesoine, Pedro-Antonio Regidor
Polycystic ovarian syndrome (PCOS) is one of the pathological factors involved in the failure of in vitro fertilization (IvF). The aim of the present study was to investigate if the combination of myoinositol + folic acid was able to improve the oocyte quality, the ratio between follicles and retrieved oocytes, the fertilization rate, and the embryo quality in PCOS patients undergoing IvF treatments. 29 patients with PCOS underwent IvF protocols for infertility treatment and were randomized prospectively into two groups...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/25854593/myoinositol-improves-sperm-parameters-and-serum-reproductive-hormones-in-patients-with-idiopathic-infertility-a-prospective-double-blind-randomized-placebo-controlled-study
#5
RANDOMIZED CONTROLLED TRIAL
A E Calogero, G Gullo, S La Vignera, R A Condorelli, A Vaiarelli
Male infertility is a multifactorial disorder that affects a significant percentage of couples. Its etiology and pathogenesis remain elusive in about one-third of the cases; this is referred to as idiopathic infertility. Inositols mediate the sperm processes involved into oocyte fertilization, such as penetration of the ovum cumulus oophorus, binding with the zona pellucida and the acrosome reaction. The aim of this double-blind, randomized, placebo-controlled trial was to evaluate the efficacy and safety of myoinositol (the most abundant form of inositols present in nature) treatment in men with idiopathic infertility...
May 2015: Andrology
https://www.readbyqxmd.com/read/25054962/-myo-inositol-in-the-treatment-of-polycystic-ovary-syndrome
#6
REVIEW
P Křepelka
OBJECTIVE: Presentation of a comprehensive body of knowledge on the role of insulin sensitizer myo-inositol in the treatment of polycystic ovary syndrome (PCOS). DESIGN: Review article. SETTING: Institute for the Care of Mother and Child, Prague. METHOD: An overview of publishing data. RESULTS AND CONCLUSION: Polycystic ovary syndrome is the most common cause of ovarian dysfunction and anovulatory infertility in women...
June 2014: Ceská Gynekologie
https://www.readbyqxmd.com/read/21744744/effects-of-myo-inositol-supplementation-on-oocyte-s-quality-in-pcos-patients-a-double-blind-trial
#7
RANDOMIZED CONTROLLED TRIAL
L Ciotta, M Stracquadanio, I Pagano, A Carbonaro, M Palumbo, F Gulino
BACKGROUND: Polycystic ovary syndrome is the most common cause of chronic anovulation infertility in women in fertile period, and it's characterized by an increased production of androgens and estrogens. The administration of myo-inositol, a B complex vitamin, was associated with a decreased of serum testosterone and simultaneously, due to its ability to increase insulin sensitivity, women who received myo-inositol showed a great improvement of the ovulary function. Besides, the supplementation of inositol improves the oocytes' quality and increase the number of oocytes collected after ovarian stimulation in patients undergoing IVF (in vitro fertilization)...
May 2011: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/21608442/myo-inositol-rather-than-d-chiro-inositol-is-able-to-improve-oocyte-quality-in-intracytoplasmic-sperm-injection-cycles-a-prospective-controlled-randomized-trial
#8
RANDOMIZED CONTROLLED TRIAL
V Unfer, G Carlomagno, P Rizzo, E Raffone, S Roseff
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common cause of infertility due to menstrual dysfunction, and the most promising treatments for this disease are insulin sensitising agents. Myo-inositol and D-chiro-inositol are insulin sensitizing agents used in PCOS treatment. In the present paper, we aimed to compare the effects myo-inositol and D-chiro-inositol on oocyte quality in euglycemic PCOS patients. MATERIALS AND METHODS: Eighty-four euglycemic PCOS patients, undergoing ovulation induction for ICSI, were recruited for this study...
April 2011: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/21434479/effects-of-myoinositol-on-sperm-mitochondrial-function-in-vitro
#9
R A Condorelli, S La Vignera, F Di Bari, V Unfer, A E Calogero
BACKGROUND AND OBJECTIVES: Inositol is a component of the vitamin B complex. Myo-inositol (MYO) is the most biologically important form in nature. It is involved in several systemic processes and in mechanisms of signal transduction in the plasma membrane as precursor of second messengers. On the male reproductive function, MYO appears to regulate seminal plasma osmolarity and volume; the expression of proteins essential for embryogenetic development and sperm chemiotaxis; and sperm motility, capacitation, and acrosome reaction...
February 2011: European Review for Medical and Pharmacological Sciences
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