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https://www.readbyqxmd.com/read/28739640/egcg-ameliorates-high-fat-and-high-fructose-induced-cognitive-defects-by-regulating-the-irs-akt-and-erk-creb-bdnf
#1
Yashi Mi, Guoyuan Qi, Rong Fan, Qinglian Qiao, Yali Sun, Yuqi Gao, Xuebo Liu
Obesity, which is caused by an energy imbalance between calorie intake and consumption, has become a major international health burden. Obesity increases the risk of insulin resistance and age-related cognitive decline, accompanied by peripheral inflammation. (-)-Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, possesses antioxidant, anti-inflammatory, and cardioprotective activities; however, few reports have focused on its potential effect on cognitive disorders. In this study, our goal was to investigate the protective effects of EGCG treatment on insulin resistance and memory impairment induced by a high-fat and high-fructose diet (HFFD)...
July 24, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28735968/epidemiology-and-clinical-features-of-green-pit-viper-trimeresurus-trigonocephalus-envenoming-in-sri-lanka
#2
R M M K Namal Rathnayaka, P E A N Ranathunga, S A M Kularatne
Green pit viper is a venomous endemic snake in Sri Lanka. But little is known regarding its envenoming in the country. This study was carried out in order to find out epidemiology and clinical profile of its bites. A series of 17 patients with Sri Lankan Green pit viper (Trimeresurus trigonocephalus) bites was prospectively studied over 4 years. The mean age was 36 ½ years (range 12-61 years) and comprised 14 (82%) males. Except one case, all bites occurred during day time (0600 h-1800h) due to inadvertent provocation...
July 20, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28734363/multi-energy-calibration-applied-to-atomic-spectrometry
#3
Alex Virgilio, Daniel A Gonçalves, Tina McSweeney, José A Gomes Neto, Joaquim A Nóbrega, George L Donati
Multi-energy calibration (MEC) is a novel strategy that explores the capacity of several analytes of generating analytical signals at many different wavelengths (transition energies). Contrasting with traditional methods, which employ a fixed transition energy and different analyte concentrations to build a calibration plot, MEC uses a fixed analyte concentration and multiple transition energies for calibration. Only two calibration solutions are required in combination with the MEC method. Solution 1 is composed of 50% v v(-1) sample and 50% v v(-1) of a standard solution containing the analytes...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734044/metabolomic-analysis-reveals-the-composition-differences-in-13-chinese-tea-cultivars-of-different-manufacturing-suitabilities
#4
Pengliang Li, Weidong Dai, Meiling Lu, Dongchao Xie, Junfeng Tan, Chen Yang, Yin Zhu, Haipeng Lv, Qunhua Peng, Yue Zhang, Li Guo, Dejiang Ni, Zhi Lin
BACKGROUND: Green tea and black tea are manufactured using appropriate tea cultivars in China. However, the metabolite differences relating to the manufacturing suitability of tea cultivars are unclear. In this study, we performed a non-targeted metabolomic analysis on 13 Chinese tea cultivars using ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) to investigate comprehensively the metabolite differences between cultivars suitable for manufacturing green tea (GT cultivars) and cultivars suitable for manufacturing both green tea and black tea (G&BT cultivars)...
July 22, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28734036/-epicatechin-regulates-blood-lipids-and-attenuates-hepatic-steatosis-in-rats-fed-high-fat-diet-%C3%A2
#5
Hui Cheng, Na Xu, Wenxia Zhao, Jingjing Su, Mengru Liang, Zhongwen Xie, Xianli Wu, Qinglin Li
SCOPE: (-)-Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea and a variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechanisms were investigated. METHODS AND RESULTS: A hyperlipidemic rat model was induced by high-fat, high-cholesterol diet. EC was then administrated to the animals by gavage at doses of 10 mg/kg, 20 mg/kg, 40 mg/kg body weight (BW) for 12 weeks. Simvastatin was included as a positive control...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28726273/epigallocatechin-gallate-enhances-treatment-efficacy-of-oral-nifedipine-against-pregnancy-induced-severe-pre-eclampsia-a-double-blind-randomized-and-placebo-controlled-clinical-study
#6
D-D Shi, J-J Guo, L Zhou, N Wang
WHAT IS KNOWN AND OBJECTIVE: Oral nifedipine is commonly used to treat pre-eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health especially hypertension. We investigated the clinical efficacy of EGCG, when complemented with oral nifedipine, in treating pre-eclampsia. METHODS: A total of 350 pregnant women with severe pre-eclampsia were recruited and randomized to receive oral nifedipine, together with placebo (NIF+placebo) or EGCG (NIF+EGCG)...
July 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28725904/cellular-antioxidant-methylglyoxal-trapping-and-anti-inflammatory-activities-of-cocoa-tea-camellia-ptilophylla-chang
#7
Xiong Gao, Xiaorong Lin, Xiaofei Li, Yuanyuan Zhang, Zhongzheng Chen, Bin Li
Cocoa tea (Camellia ptilophylla Chang) is a naturally low caffeine-containing but gallocatechin gallate (GCG)-rich tea cultivar, though its biological activities have not been extensively explored. Herein, we evaluated the in vitro cellular antioxidant, methylglyoxal trapping, and anti-inflammatory activities of water extract of green tea from cocoa tea (CWE) and Yunnan Daye tea (Camellia sinensis) (YWE), and their predominant bioactive components GCG and epigallocatechin gallate (EGCG) for comparative purposes...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28723689/a-randomized-controlled-trial-of-green-tea-beverages-on-the-in-vivo-radical-scavenging-activity-in-human-skin
#8
Inna Megow, Maxim E Darvin, Martina C Meinke, Jürgen Lademann
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. METHODS: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin...
July 20, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28722393/multiligand-metal-phenolic-assembly-from-green-tea-infusions
#9
Md Arifur Rahim, Mattias Björnmalm, Nadja Bertleff-Zieschang, Yi Ju, Srinivas Mettu, Michael G Leeming, Frank Caruso
The synthesis of hybrid functional materials using the coordination-driven assembly of metal-phenolic networks (MPNs) is of interest in diverse areas of materials science. To date, MPN assembly has been explored as monoligand systems (i.e., containing a single type of phenolic ligand) where the phenolic components are primarily obtained from natural sources via extraction, isolation, and purification processes. Herein, we demonstrate the fabrication of MPNs from a readily available, crude phenolic source-green tea (GT) infusions...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721420/adsorption-of-galloyl-catechin-aggregates-significantly-modulates-membrane-mechanics-in-the-absence-of-biochemical-cues
#10
Takahisa Matsuzaki, Hiroaki Ito, Veronika Chevyreva, Ali Makky, Stefan Kaufmann, Kazuki Okano, Naritaka Kobayashi, Masami Suganuma, Seiichiro Nakabayashi, Hiroshi Y Yoshikawa, Motomu Tanaka
Physical interactions of four major green tea catechin derivatives with cell membrane models were systemically investigated. Catechins with the galloyl moiety caused the aggregation of small unilamellar vesicles and an increase in the surface pressure of lipid monolayers, while those without did not. Differential scanning calorimetry revealed that, in a low concentration regime (≤10 μM), catechin molecules are not significantly incorporated into the hydrophobic core of lipid membranes as substitutional impurities...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28721200/protein-bound-polyphenols-create-ghost-band-artifacts-during-chemiluminescence-based-antigen-detection
#11
Nathalie Plundrich, Mary Ann Lila, Edward Foegeding, Scott Laster
Antigen detection during Western blotting commonly utilizes a horseradish peroxidase-coupled secondary antibody and enhanced chemiluminescent substrate. We utilized this technique to examine the impact of green tea-derived polyphenols on the binding of egg white protein-specific IgE antibodies from allergic human plasma to their cognate antigens. Our experiments unexpectedly showed that green tea-derived polyphenols, when stably complexed with egg white proteins, caused hyperactivation of horseradish peroxidase resulting in the appearance of white "ghost" bands...
2017: F1000Research
https://www.readbyqxmd.com/read/28720978/extraction-and-preparation-of-high-aroma-and-low-caffeine-instant-green-teas-by-the-novel-column-chromatographic-extraction-method-with-gradient-elution
#12
Qing-Rong Li, Min Wu, Rui-Jie Huang, Ya-Fei Chen, Chan-Jian Chen, Hui Li, He Ni, Hai-Hang Li
The lack of aroma and natural taste is a critical problem in production and consumption of instant green teas. A method to prepare instant green teas high in-natural-aroma and low-caffeine by the novel column chromatographic extraction with gradient elution is reported. This method simultaneously extracted aroma (or volatile) and non-aroma compounds from green tea. Green tea was loaded into columns with 2.0-fold of petroleum ether (PE): ethanol (8:2). After standing for 3 h until the aroma compounds dissolved, the column was sequentially eluted with 3...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28713815/bioinformatic-prediction-of-possible-targets-and-mechanisms-of-action-of-the-green-tea-compound-epigallocatechin-3-gallate-against-breast-cancer
#13
Xinqiang Song, Mu Zhang, Lei Chen, Qingsong Lin
Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea, is the most abundant and biologically active catechin, and it exerts multiple effects in humans through mechanisms that remain to be clarified. The present study used bioinformatics to identify possible mechanisms by which EGCG reduces risk of breast cancer. Possible human protein targets of EGCG were identified in the PubChem database, possible human gene targets were identified in the NCBI database, and then both sets of targets were analyzed using Ingenuity Pathway Analysis to predict molecular networks affected by EGCG in breast cancer...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28707966/targeted-molecular-ablation-of-cancer-stem-cells-for-curing-gastrointestinal-cancers
#14
Yong Seok Kim, Ho Jae Lee, Jong-Min Park, Young-Min Han, Napapan Kangwan, Ji Young Oh, Dong Yoon Lee, Ki Baik Hahm
Abundance of the ATPase-binding cassette (ABC) transporters and deranged self-renewal pathways characterize the presence of cancer stem cells (CSCs) in gastrointestinal cancers (GI cancers), which play crucial roles in tumorigenesis, chemotherapy resistance, tumor recurrence, and cancer metastasis. Therefore, in order to ensure high cure rates, chemoquiescence, CSCs should be ablated. Recent advances in either understanding CSCs or biomarker identification enable scientists to develop techniques for ablating CSCs and clinicians to provide cancer cure, especially in GI cancers characterized by inflammation-driven carcinogenesis...
July 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28704984/the-effect-of-personal-familial-and-enviroinmental-characteristics-on-acne-vulgaris-a-prospective-multicenter-case-controlled-study-from-turkey
#15
Ayşe S Karadağ, İlknur Balta, Hayriye Saricaoğlu, Selim Kiliç, Kıymet H Kelekçi, Mehmet Yildirim, Deniz A Arica, Savaş Öztürk, Göksun Karaman, Aslı A Çerman, Serap G Bilgili, Enver Turan, Mustafa M Demirci, Tuğba K Uzunçakmak, Serdar C Güvenç, Arzu Ataseven, Ayten Ferahbaş, Berna Aksoy, Emine Çölgeçen, Özlem Ekiz, Filiz Topaloğlu Demir, Özlem Bilgiç, Seray Çakmak, Derya Uçmak, Pınar Özuğuz, Yeşim Kaymak Konkuralp, Aylin T Ermertcan, Gonca Gökdemir, Emel Bülbül Başkan, Gökçen Alyamaç, Hatice Şanli
BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study...
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28693189/epigallocatechin-gallate-inhibits-the-growth-of-mda-mb-231-breast-cancer-cells-via-inactivation-of-the-%C3%AE-catenin-signaling-pathway
#16
On-Yu Hong, Eun-Mi Noh, Hye-Yeon Jang, Young-Rae Lee, Byoung Kil Lee, Sung Hoo Jung, Jong-Suk Kim, Hyun Jo Youn
Epigallocatechin gallate (EGCG), a major constituent of green tea, has potential as a treatment for a variety of diseases, including cancer. EGCG induces apoptosis and inhibits tumorigenesis through multiple signaling pathways in breast cancer cells. β-catenin signaling modulators could be useful in the prevention and therapy of breast cancer. However, the precise anticancer effect of EGCG through the β-catenin signaling pathway in breast cancer is unclear. The present study investigated the association between β-catenin expression and clinicopathological factors of breast cancer patients, and the effect of EGCG on β-catenin expression in breast cancer cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28683415/dissipation-kinetics-of-beta-cyfluthrin-and-imidacloprid-in-tea-and-their-transfer-from-processed-tea-to-infusion
#17
M Paramasivam, M Deepa, C Selvi, S Chandrasekaran
Dissipation kinetics of mixed formulation consisting beta-cyfluthrin and imidacloprid in tea crop under an open field ecosystem was investigated. The mixed formulation was applied on tea plant at recommended (27 + 63) and double the recommended (54 + 126g a.i./ha) dose and residues were determined using gas chromatography-electron capture detector and high performance liquid chromatography-photodiode array detector for beta-cyfluthrin and imidacloprid, respectively. The limit of quantification of analytical method was 0...
July 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28680384/randomized-controlled-trial-of-the-effects-of-consumption-of-yabukita-or-benifuuki-encapsulated-tea-powder-on-low-density-lipoprotein-cholesterol-level-and-body-weight
#18
Yuko Igarashi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Michiko Shigihara, Hirohito Metoki, Masahiro Kikuya, Yoichi Sameshima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama
Background: Previous studies have reported controversial results for the association between green tea consumption and low-density lipoprotein (LDL)-cholesterol and body weight. Objective: The objective of this trial was to determine the effects of two kinds of green tea on LDL-cholesterol and body weight. Methods: We randomly assigned 151 participants (98 men, 53 women) aged 30-70 years into three groups: Yabukita green tea group, Benifuuki green tea group, or placebo group. Participants consumed 1.8 g/day of green tea extract powder or placebo for 12 weeks...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28679060/protective-effects-of-green-tea-polyphenol-epigallocatechin-3-gallate-against-sevoflurane-induced-neuronal-apoptosis-involves-regulation-of-creb-bdnf-trk-b-and-pi3k-akt-mtor-signalling-pathways-in-neonatal-mice
#19
Mei-Li Ding, Hui Ma, Yi-Gang Man, Yan-Hong Lv
Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea is an effective antioxidant and possesses neuroprotective effects. For neurogenesis and synaptic plasticity, brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucially involved. In this study we aimed to assess protective effects of EGCG against sevoflurane-induced neurotoxicity in neonatal mice. Distinct groups of C57BL/6 mice were given EGCG (25, 50 or 75 mg/kg b.wt) from postnatal day 3 (P3) to P21 and were subjected to sevoflurane (3 %; 6 h) exposure on P7...
July 5, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28678746/long-term-supplementation-of-decaffeinated-green-tea-extract-does-not-modify-body-weight-or-abdominal-obesity-in-a-randomized-trial-of-men-at-high-risk-for-prostate-cancer
#20
Nagi B Kumar, Roshni Patel, Julio Pow-Sang, Philippe E Spiess, Raoul Salup, Christopher R Williams, Michael J Schell
BACKGROUND: Evidence continues to demonstrate the role of obesity in prostate carcinogenesis and prognosis, underscoring the need to identify and continue to evaluate the effective interventions to reduce obesity in populations at high risk. The aim of the study was to determine the effect of daily consumption of decaffeinated green tea catechins (GTC) formulation (Polyphenon E® (PolyE)) for 1 year on biomarkers of obesity in men who are at high risk for prostate cancer. MATERIALS AND METHODS: A randomized, double-blinded trial was conducted targeting 97 men diagnosed with HGPIN or ASAP...
June 29, 2017: Oncotarget
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