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https://www.readbyqxmd.com/read/28103535/down-regulation-of-histone-deacetylase-4-5-and-6-as-a-mechanism-of-synergistic-enhancement-of-apoptosis-in-human-lung-cancer-cells-treated-with-the-combination-of-a-synthetic-retinoid-am80-and-green-tea-catechin
#1
Yukiko Oya, Anupom Mondal, Anchalee Rawangkan, Sonthaya Umsumarng, Keisuke Iida, Tatsuro Watanabe, Miki Kanno, Kaori Suzuki, Zhenghao Li, Hiroyuki Kagechika, Koichi Shudo, Hirota Fujiki, Masami Suganuma
(-)-Epigallocatechin gallate (EGCG), a green tea catechin, acts as a synergist with various anticancer drugs, including retinoids. Am80 is a synthetic retinoid with a different structure from all-trans-retinoic acid: Am80 is now clinically utilized as a new drug for relapsed and intractable acute promyelocytic leukemia patients. Our experiments showed that the combination of EGCG and Am80 synergistically induced both apoptosis in human lung cancer cell line PC-9 and up-regulated expressions of growth arrest and DNA damage-inducible gene 153 (GADD153), death receptor 5, and p21(waf1) genes in the cells...
January 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28103249/the-green-tea-catechin-epigallocatechin-gallate-ameliorates-graft-versus-host-disease
#2
Sabine Westphal, Aleixandria McGeary, Sandra Rudloff, Andrea Wilke, Olaf Penack
Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is a standard treatment for leukemia and other hematologic malignancies. The major complication of allo-HSCT is graft-versus-host-disease (GVHD), a progressive inflammatory illness characterized by donor immune cells attacking the organs of the recipient. Current GVHD prevention and treatment strategies use immune suppressive drugs and/or anti-T cell reagents these can lead to increased risk of infections and tumor relapse. Recent research demonstrated that epigallocatechin gallate (EGCG), a component found in green tea leaves at a level of 25-35% at dry weight, may be useful in the inhibition of GVHD due to its immune modulatory, anti-oxidative and anti-angiogenic capacities...
2017: PloS One
https://www.readbyqxmd.com/read/28103237/adult-tea-green-leafhoppers-empoasca-onukii-matsuda-change-behaviors-under-varying-light-conditions
#3
Longqing Shi, Liette Vasseur, Huoshui Huang, Zhaohua Zeng, Guiping Hu, Xin Liu, Minsheng You
Insect behaviors are often influenced by light conditions including photoperiod, light intensity, and wavelength. Understanding pest insect responses to changing light conditions may help with developing alternative strategies for pest control. Little is known about the behavioral responses of leafhoppers (Hemiptera: Cicadellidae) to light conditions. The behavior of the tea green leafhopper, Empoasca onukii Matsuda, was examined when exposed to different light photoperiods or wavelengths. Observations included the frequency of locomotion and cleaning activities, and the duration of time spent searching...
2017: PloS One
https://www.readbyqxmd.com/read/28100100/a-new-update-for-radiocontrast-induced-nephropathy-aggravated-with-glycerol-in-rats-the-protective-potential-of-epigallocatechin-3-gallate
#4
Saziye Sezin Palabiyik, Busra Dincer, Elif Cadirci, Irfan Cinar, Cemal Gundogdu, Beyzagul Polat, Muhammed Yayla, Zekai Halici
Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its mechanisms of protection against toxicity, using models of GLY and CIN in rats. The rats were separated into eight groups (n = 6 in each), as follows: Healthy, GLY, CM, GLY + CM, CM + EGCG 50 mg/kg (po), GLY + CM + EGCG 50 mg/kg (po), CM + EGCG 100 mg/kg (po), and GLY + CM + EGCG 100 mg/kg (po)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28097041/effect-of-catechins-green-tea-extract-and-methylxanthines-in-combination-with-gentamicin-against-staphylococcus-aureus-and-pseudomonas-aeruginosa-combination-therapy-against-resistant-bacteria
#5
Bibi Sedigheh Fazly Bazzaz, Sahar Sarabandi, Bahman Khameneh, Hossein Hosseinzadeh
OBJECTIVES: Bacterial resistant infections have become a global health challenge and threaten the society's health. Thus, an urgent need exists to find ways to combat resistant pathogens. One promising approach to overcoming bacterial resistance is the use of herbal products. Green tea catechins, the major green tea polyphenols, show antimicrobial activity against resistant pathogens. The present study aimed to investigate the effect of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus (S...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28096402/establishment-of-expression-state-boundaries-by-rif1-and-taz1-in-fission-yeast
#6
Tea Toteva, Bethany Mason, Yutaka Kanoh, Peter Brøgger, Daniel Green, Janne Verhein-Hansen, Hisao Masai, Geneviève Thon
The Shelterin component Rif1 has emerged as a global regulator of the replication-timing program in all eukaryotes examined to date, possibly by modulating the 3D-organization of the genome. In fission yeast a second Shelterin component, Taz1, might share similar functions. Here, we identified unexpected properties for Rif1 and Taz1 by conducting high-throughput genetic screens designed to identify cis- and trans-acting factors capable of creating heterochromatin-euchromatin boundaries in fission yeast. The preponderance of cis-acting elements identified in the screens originated from genomic loci bound by Taz1 and associated with origins of replication whose firing is repressed by Taz1 and Rif1...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095073/preclinical-and-potential-applications-of-common-western-herbal-supplements-as-complementary-treatment-in-parkinson-s-disease
#7
Luke A Morgan, Oliver Grundmann
Parkinson's disease (PD) is a neurological disorder with a complex pathological etiology, which is not fully understood. Progression of PD may be the result of a buildup of iron in the substantia nigra, microglia-mediated neuroinflammation, dysfunctional mitochondria, or abnormal protein handling. Dopamine is the main neurotransmitter affected, but as the disease progresses, a decrease in all the brain's biogenic amines occurs. Current medication used in the treatment of PD aims to prevent the breakdown of dopamine or increase dopaminergic neurotransmission in the central nervous system...
January 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28095030/green-tea-consumption-and-the-risk-of-liver-cancer-a-meta-analysis
#8
Chen-Xu Ni, Hong Gong, Ying Liu, Yang Qi, Chun-Lei Jiang, Jun-Ping Zhang
Green tea is a commonly consumed beverage in Asia and has been suggested to have anticarcinogenic properties. To date, epidemiological evidence of the effect of green tea consumption on liver cancer risk remains ambiguous. The aim of this meta-analysis is to evaluate the association between green tea consumption and the risk of liver cancer. The summary relative risk for the highest consumption (≥5 cups/day) of green tea on liver cancer incidence compared with nondrinkers was 0.62 (95% confidence interval: 0...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28093297/bottom-up-synthesis-of-carbon-nanoparticles-with-higher-doxorubicin-efficacy
#9
Samer Bayda, Mohamad Hadla, Stefano Palazzolo, Vinit Kumar, Isabella Caligiuri, Emmanuele Ambrosi, Enrico Pontoglio, Marco Agostini, Tiziano Tuccinardi, Alvise Benedetti, Pietro Riello, Vincenzo Canzonieri, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio
Nanomedicine requires intelligent and non-toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects. Interest in carbon nanoparticles (CNPs) is increasing because they are considered green materials with tunable optical properties, overcoming the problem of toxicity associated with quantum dots or nanocrystals, and can be utilized as smart drug delivery systems. Using black tea as a raw material, we synthesized CNPs with a narrow size distribution, tunable optical properties covering visible to deep red absorption, non-toxicity and easy synthesis for large-scale production...
January 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28092827/conjugated-polymer-with-carboxylate-groups-hg-2-system-as-a-turn-on-fluorescence-probe-for-label-free-detection-of-cysteine-containing-compounds
#10
Hongyu Mi, Mingming Guan, Jilin Liu, Hongyan Shan, Qiang Fei, Yanfu Huan, Guodong Feng
In this work, a turn on fluorescent sensor, based on Hg(2+) coordination conjugated polymer, was developed to detect cysteine-containing compounds. The fluorescence of conjugated polymer (poly(2,5-bis (sodium 4-oxybutyrate) -1,4 - phenylethynylene-alt-1,4-phenyleneethynylene; PPE-OBS) would be quenched by Hg(2+) because of the coordination-induced aggregation and electron transfers of PPE-OBS toward Hg(2+). When there were some cysteine-containing compounds in PPE-OBS-Hg(2+) system, the fluorescence of PPE-OBS would be recovered...
January 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28090275/induction-of-epigenetic-alteration-by-cpuk02-an-ent-kaurenoid-derivative-of-stevioside
#11
Pooneh Mokarram, Zeinab Mohammadi, Saeid Khazayel, Zhang Dayong
BACKGROUND: Dietary polyphenols, such as those found in green tea and red wine, are linked to antitumor activity. They are known to influence many signaling pathways epigenetically within the human body. In this regard, CPUK02 (15-Oxosteviol benzyl ester) is a new ent-kaurenoid derivative of stevioside and exhibits strong anti-cancer activity in vitro and in vivo. Nowadays, the role of epigenetics in cancer has been the subject of intensive study and DNA methylation targeting represents a relevant strategy for cancer treatment...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28079202/oligomer-formation-of-a-tea-polyphenol-egcg-on-its-sensing-molecule-67-kda-laminin-receptor
#12
Yuhui Huang, Mami Sumida, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, Yoshinori Fujimura, Hirofumi Tachibana
Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28077264/self-assembly-of-green-tea-catechin-derivatives-in-nanoparticles-for-oral-lycopene-delivery
#13
Weikun Li, Murat Yalcin, Qishan Lin, Mohammed-Salleh M Ardawi, Shaker A Mousa
Lycopene is a natural anti-oxidant that has attracted much attention due to its varied applications such as protection against loss of bone mass, chronic diseases, skin cancer, prostate cancer, and cardiovascular disease. However, high instability and extremely low oral bioavailability limits its further clinical development. We selected a green tea catechin derivative, oligomerized (-)-epigallocatechin-3-O-gallate (OEGCG) as a carrier for oral lycopene delivery. Lycopene-loaded OEGCG nanoparticles (NPs) were prepared by a nano-precipitation method, followed by coating with chitosan to form a shell...
January 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28071811/extraction-of-epigallocatechin-gallate-and-epicatechin-gallate-from-tea-leaves-using-%C3%AE-cyclodextrin
#14
Lu Cui, Yuxuan Liu, Ting Liu, Yahong Yuan, Tianli Yue, Rui Cai, Zhouli Wang
Use of organic solvents to extract phenolic compounds from plants may result in environmental pollution and cause health problems in persons. Replacing organic extraction solvents by green extracting agents without affecting the extraction yield is one of the most pressing problems to be solved. The aim of this study is to evaluate the capacity of β-cyclodextrin (β-CD) to recover phenolic compounds from tea leaves. The extract obtained using the ethanol/water mixture presented the highest total phenolic content, followed by those obtained using β-CD solution and water...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28071801/formation-and-characterization-of-green-tea-extract-loaded-liposomes
#15
Damla Dag, Mecit Halil Oztop
Green tea extract was encapsulated into liposomes to enhance bioavailability and stability of catechins by protecting their functional properties simultaneously. Encapsulation was achieved by dispersing 1% (w/v) soy lecithin through high pressure homogenization (microfluidization) and ultrasonication. Effects of homogenization type and pH of the dispersing medium on the physical properties and stability of the liposomes during 1-mo storage period were investigated. Mean particle size, total phenolic content by Folin-Ciocalteu method and antioxidant activity by 2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reducing-antioxidant power methods, and transmission electron microscopy (TEM) experiments were conducted for characterization...
January 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28070314/calories-and-sugars-in-boba-milk-tea-implications-for-obesity-risk-in-asian-pacific-islanders
#16
Jae Eun Min, David B Green, Loan Kim
In the last several decades, obesity rates have reached epidemic proportions, and increases the risk for a host of comorbidities, including diabetes, cardiovascular disease, and certain kinds of cancers. Boba milk tea, first became popular in the 1990s throughout Asia, and has gained more popularity in the United States and in Europe since 2000. Currently, available nutrition data from online sites suggest this beverage contains high amounts of sugar and fat. One published nutrition study suggests that boba tea drinks are part of the larger group of sugar-sweetened beverages (SSB) because these beverages are usually sweetened with high-fructose corn syrup (HFCS)...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28068348/optical-determination-of-lead-chrome-green-in-green-tea-by-fourier-transform-infrared-ft-ir-transmission-spectroscopy
#17
Xiaoli Li, Kaiwen Xu, Yuying Zhang, Chanjun Sun, Yong He
The potential of Fourier transform infrared (FT-IR) transmission spectroscopy for determination of lead chrome green in green tea was investigated based on chemometric methods. Firstly, the qualitative analysis of lead chrome green in tea was performed based on partial least squares discriminant analysis (PLS-DA), and the correct rate of classification was 100%. And then, a hybrid method of interval partial least squares (iPLS) regression and successive projections algorithm (SPA) was proposed to select characteristic wavenumbers for the quantitative analysis of lead chrome green in green tea, and 19 wavenumbers were obtained finally...
2017: PloS One
https://www.readbyqxmd.com/read/28064485/astragalin-inhibits-allergic-inflammation-and-airway-thickening-in-ovalbumin-challenged-mice
#18
Yun-Ho Kim, Yean-Jung Choi, Min-Kyung Kang, Sin-Hye Park, Lucia Dwi Antika, Eun-Jung Lee, Dong Yeon Kim, Young-Hee Kang
Lung inflammation and oxidative stress are the major contributors to the development of obstructive pulmonary diseases. Macrophages are involved in pulmonary inflammation and alveolar damage in emphysema. Astragalin is an anti-inflammatory flavonoid present in persimmon leaves and green tea seeds. This study elucidated that astragalin inhibited inflammatory cell infiltration induced by 20 μM H2O2 and blocked airway thickening and alveolar emphysema induced by 20 μg of ovalbumin (OVA) in mice. OVA induced mouse pulmonary MCP-1, and H2O2 enhanced the expression of MCP-1/ICAM-1/αv integrin in bronchial airway epithelial BEAS-2B cells...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28058738/epigallocatechin-3-gallate-egcg-and-green-tea-polyphenols-do-not-improve-stallion-semen-parameters-during-cooling-at-4%C3%A2-c
#19
D Bucci, M Spinaci, B Mislei, B Gadani, G Rizzato, C C Love, C Tamanini, G Galeati, G Mari
Stallion semen storage for artificial insemination is mainly based on liquid cooled storage. In many stallions this technique maintains sperm quality for an extended period of time (24-72 hr) at 7°C. While this technique is commonly used in the horse industry, there can be a decline in fertility in some stallions, due to an inability of their sperm to tolerate the cool storage process. The aim of the present work was to evaluate the effect of two natural antioxidants (epigallocatechin-3-gallate (EGCG) at 20, 60 and 120 μm and green tea polyphenols, and p at ...
January 6, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28057147/-tea-coffee-intakes-and-risk-of-oral-squamous-cell-carcinoma-a-case-control-study
#20
L J Yan, F Chen, D M Liu, J F Huang, F P Liu, J F Wu, F Q Liu, J Z Ye, Y Qiu, L S Lin, B C He
Objective: To evaluate the effects of tea and coffee intakes on oral squamous cell carcinoma (OSCC) stratified by milk intake. Methods: A case-control study involving 593 OSCC patients confirmed by pathological diagnoses and 1 128 gender-age frequency matched controls was conducted in Fujian province during September 2010-March 2016. Unconditional logistic regression was used to calculate adjusted odds ratios (aORs) and corresponding 95% confidence intervals (CIs) to assess the effects of coffee, tea intakes and related variables on OSCC...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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