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https://www.readbyqxmd.com/read/29679935/the-role-of-adsorbate-size-on-adsorption-of-ne-and-xe-on-graphite
#1
Luisa Prasetyo, Quang K Loi, Shiliang Johnathan Tan, D D Do, D Nicholson
We have carried out an extensive grand canonical Monte Carlo simulation to investigate the adsorption of neon and xenon on graphite. The adsorbate collision diameters of neon and xenon are smaller and greater respectively, than the commensurate graphite lattice spacing λ=3×3R300 of 0.426 nm. Simulated isotherms and isosteric heats were obtained using a graphite model that has been shown to describe successfully the adsorbate transitions for krypton, methane and nitrogen by Prasetyo et al. (2017), which have collision diameters close to λ...
April 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29679906/microrna-876-5p-inhibits-epithelial-mesenchymal-transition-and-metastasis-of-hepatocellular-carcinoma-by-targeting-bcl6-corepressor-like-1
#2
Qiuran Xu, Qiaojuan Zhu, Zhenyu Zhou, Yufeng Wang, Xin Liu, Guozhi Yin, Xiangmin Tong, Kangsheng Tu
Our previous study has reported that BCL6 corepressor like 1 (BCORL1) plays an oncogenic role in hepatocellular carcinoma (HCC) via promoting epithelial-mesenchymal transition (EMT) and tumor metastasis. However, the regulation of BCORL1 mediated by microRNAs (miRNAs) remains poorly known. The analysis of our clinical samples indicated that BCORL1 expression was markedly higher in HCC tissues than that in tumor-adjacent normal tissues. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets revealed that high BCORL1 expression associated with high tumor grade, advanced tumor stage and poor survival of HCC patients...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679839/xenon-detection-in-human-blood-analytical-validation-by-accuracy-profile-and-identification-of-critical-storage-parameters
#3
Cécile Frampas, Julia Ney, Mark Coburn, Marc Augsburger, Vincent Varlet
Xenon is a rare, mostly inert, noble gas that has applications in a wide range of fields, including medicine. Xenon acts on the human body as a useful organ-protective and anesthetic agent and has also been previously studied for potential applications in fields such as optics, aerospace and medical imaging. Recently, it was discovered that xenon can boost erythropoietin production, and it has been used as a performance-enhancing agent in international sports competitions such as the Sochi Olympic Games. Therefore, screening methods to detect the misuse of xenon by analysis of biological samples and to monitor anesthesia kinetics and efficiency are being investigated...
April 13, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29679799/refolding-kinetics-of-cytochrome-c-studied-with-microsecond-timescale-continuous-flow-uv-vis-spectroscopy-and-rapid-freeze-quench-epr
#4
Batoul Srour, Marc J F Strampraad, Wilfred R Hagen, Peter-Leon Hagedoorn
The study of the structure, function, folding and conformational transitions of cytochrome c is of great interest because this protein plays an important role in biological electron transport and apoptosis. The different native and non-native conformations have been studied extensively under equilibrium conditions at different pH values, however, kinetic studies are rare because they require technically challenging rapid mixing and spectroscopic monitoring techniques. Here we present the refolding kinetics of acid denatured cytochrome c using the pH jump technique from pH 2 to pH 4...
April 11, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29679763/leaving-the-nest-improving-food-allergy-management-on-college-campuses
#5
Ashley A Dyer, Amy O'Keefe, Madeleine K Kanaley, Lauren Kao, Ruchi S Gupta
BACKGROUND: The transition from adolescence to young adulthood marks a developmental period where responsibility for management of chronic conditions such as food allergy shifts from the caregiver to the young adult. Fatal food-induced anaphylaxis is most common among adolescents and young adults. However, colleges are currently not well-positioned to provide integrated support for students with food allergies. OBJECTIVE: The study objective was to explore the systems, structures, and policies that currently support students with food allergies at college, assess unmet needs, and develop pilot interventions through the use of patient-centered design processes...
April 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29679750/a-fast-and-reliable-dsc-based-method-to-determine-the-monomolecular-loading-capacity-of-drugs-with-good-glass-forming-ability-in-mesoporous-silica
#6
Nele-Johanna Hempel, Katharina Brede, Niels Erik Olesen, Natalja Genina, Matthias Manne Knopp, Korbinian Löbmann
The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a heat-cool-heat cycle in the DSC. Overloaded drug-MS systems were analyzed in the DSC at different drug ratios (50, 60, 70, 80 and 90% w/w) to quantify the excess drug in the (the fraction not adsorbed to the MS surface)...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29679566/matrix-stiffness-regulate-apoptotic-cell-death-in-hiv-hcv-co-infected-hepatocytes-importance-for-liver-fibrosis-progression
#7
Murali Ganesan, Raghubendra Singh Dagur, Edward Makarov, Larisa I Poluektova, Srivatsan Kidambi, Natalia A Osna
HIV-HCV co-infection causes rapid progression of liver fibrosis. These outcomes to liver cirrhosis can be improved, but not stopped by specific antiviral therapies. Due to high significance of HIV-HCV interactions for morbidity and mortality in co-infected patients, our attention was attracted to the multi-component pathogenesis of fibrosis progression as the transition to end-stage liver disease development. In this study, we hypothesize that increased matrix stiffness enhances apoptosis in HCV-HIV-co-infected hepatocytes and that capturing of apoptotic bodies (AB) derived from these infected hepatocytes by hepatic stellate cells (HSC) drives the fibrosis progression...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679540/the-free-energy-of-biomembrane-and-nerve-excitation-and-the-role-of-anesthetics
#8
Tian Wang, Tea Mužić, Andrew D Jackson, Thomas Heimburg
In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane. It is a function of temperature and pressure, and it is sensitively dependent on the presence of anesthetics which lower melting transitions. We investigate the free energy difference of solid and liquid membrane phases under the influence of anesthetics...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29679377/clinical-characteristics-of-long-term-survival-with-non-invasive-ventilation-and-factors-affecting-the-transition-to-invasive-ventilation-in-als
#9
Takahiko Hirose, Fumiharu Kimura, Hiroki Tani, Shin Ota, Akihiro Tsukahara, Eri Sano, Taro Shigekiyo, Yoshitsugu Nakamura, Kensuke Kakiuchi, Mikiko Motoki, Kiichi Unoda, Simon Ishida, Hideto Nakajima, Shigeki Arawaka
Introduction We evaluated post non-invasive ventilation survival and factors for the transition to tracheostomy in amyotrophic lateral sclerosis. Methods We analyzed 197 patients using a prospectively-collected database, with 114 patients since 2000. Results Of 114 patients, 59 patients underwent non-invasive ventilation (NIV), which prolonged the total median survival time to 43 months compared with 32 months without treatment. The best post-NIV survival was associated with a lack of bulbar symptoms, higher measured pulmonary function, and a slower rate of progression at diagnosis...
April 20, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29679372/paraneoplastic-cerebellar-degeneration-yo-antibody-alters-mitochondrial-calcium-buffering-capacity
#10
Debabrata Panja, Christian A Vedeler, Manja Schubert
AIM: Neurodegeneration is associated with dysfunction of calcium buffering capacity and thereby sustained cellular and mitochondrial calcium overload. Paraneoplastic cerebellar degeneration (PCD), characterized by progressive Purkinje neuron degeneration following paraneoplastic Yo antibody internalisation and binding to cerebellar degeneration-related protein CDR2 and CDR2L, has been linked to intracellular calcium homeostasis imbalance due to calbindin D28k malfunction. Therefore, we hypothesized that Yo antibody internalisation affects not only calbindin calcium binding capacity but also calcium-sensitive mitochondrial-associated signalling, causing mitochondrial calcium overload and thereby Purkinje neuron death...
April 21, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29679227/cypd-mptp-axis-regulates-mitochondrial-functions-contributing-to-osteogenic-dysfunction-of-mc3t3-e1-cells-in-inflammation
#11
Xueqi Gan, Ling Zhang, Beilei Liu, Zhuoli Zhu, Yuting He, Junsheng Chen, Junfei Zhu, Haiyang Yu
Bone is a dynamic organ, the bone-forming osteoblasts and bone-resorbing osteoclasts form the physiological basis of bone remodeling process. During pathological process of numerous inflammatory diseases, these two aspects are uncoupled and the balance is usually tipped in favor of bone destruction. Evidence suggests that the inflammatory destruction of bone is mainly attributed to oxidative stress and is closely related to mitochondrial dysfunction. The mechanisms underlying osteogenic dysfunction in inflammation still need further investigation...
April 20, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29679205/changes-in-the-position-and-volume-of-inactive-x-chromosomes-during-the-g0-g1-transition
#12
Guoliang Lyu, Tan Tan, Yiting Guan, Lei Sun, Qianjin Liang, Wei Tao
In female mammals, each cell silences one X chromosome by converting it into transcriptionally inert heterochromatin. The inactivation is concomitant with epigenetic changes including methylation of specific histone residues and incorporation of macroH2A. Such epigenetic changes may exert influence on the positioning of the inactive X chromosome (Xi) within the nucleus beyond the level of chromatin structure. However, the dynamic positioning of the inactive X chromosome during cell cycle remains unclear. Here, we show that H3K27me3 is a cell-cycle-independent marker for the inactivated X chromosomes in WI38 cells...
April 21, 2018: Chromosome Research
https://www.readbyqxmd.com/read/29679056/complete-agreement-of-the-post-spinel-transition-with-the-660-km-seismic-discontinuity
#13
Takayuki Ishii, Rong Huang, Hongzhan Fei, Iuliia Koemets, Zhaodong Liu, Fumiya Maeda, Liang Yuan, Lin Wang, Dmitry Druzhbin, Takafumi Yamamoto, Shrikant Bhat, Robert Farla, Takaaki Kawazoe, Noriyoshi Tsujino, Eleonora Kulik, Yuji Higo, Yoshinori Tange, Tomoo Katsura
The 660-km seismic discontinuity, which is a significant structure in the Earth's mantle, is generally interpreted as the post-spinel transition, as indicated by the decomposition of ringwoodite to bridgmanite + ferropericlase. All precise high-pressure and high-temperature experiments nevertheless report 0.5-2 GPa lower transition pressures than those expected at the discontinuity depth (i.e. 23.4 GPa). These results are inconsistent with the post-spinel transition hypothesis and, therefore, do not support widely accepted models of mantle composition such as the pyrolite and CI chondrite models...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679042/effect-of-antimicrobial-peptides-from-galleria-mellonella-on-molecular-models-of-leishmania-membrane-thermotropic-and-fluorescence-anisotropy-study
#14
Isabel Andrea Patiño-Márquez, Marcela Manrique-Moreno, Edwin Patiño-González, Małgorzata Jemioła-Rzemińska, Kazimierz Strzałka
Antimicrobial peptides are molecules of natural origin, produced by organisms such as insects, which have focused attention as potential antiparasitic agents. They can cause the death of parasites such Leishmania by interacting with their membrane. In this study, additional information was obtained on how the anionic peptide 2 and cecropin D-like peptide derived from Galleria mellonella interact with liposomes that mimic the composition of the Leishmania membrane. In order to do this, lipid bilayers consisting of dipalmitoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, dimyristoylphosphatidylserine, and dimyristoylphosphatidylglycerol were constructed...
April 20, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29679030/the-effect-of-crystallite-size-on-pressure-amplification-in-switchable-porous-solids
#15
Simon Krause, Volodymyr Bon, Irena Senkovska, Daniel M Többens, Dirk Wallacher, Renjith S Pillai, Guillaume Maurin, Stefan Kaskel
Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomena are demonstrated to critically depend on the primary crystallite size. Adsorbing probe molecules, such as n-butane or nitrogen, gives insights into size-dependent activation barriers and thermodynamics associated with guest-induced network contraction...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29679009/nucleus-accumbens-controls-wakefulness-by-a-subpopulation-of-neurons-expressing-dopamine-d-1-receptors
#16
Yan-Jia Luo, Ya-Dong Li, Lu Wang, Su-Rong Yang, Xiang-Shan Yuan, Juan Wang, Yoan Cherasse, Michael Lazarus, Jiang-Fan Chen, Wei-Min Qu, Zhi-Li Huang
Nucleus accumbens (NAc) is involved in behaviors that depend on heightened wakefulness, but its impact on arousal remains unclear. Here, we demonstrate that NAc dopamine D1 receptor (D1 R)-expressing neurons are essential for behavioral arousal. Using in vivo fiber photometry in mice, we find arousal-dependent increases in population activity of NAc D1 R neurons. Optogenetic activation of NAc D1 R neurons induces immediate transitions from non-rapid eye movement sleep to wakefulness, and chemogenetic stimulation prolongs arousal, with decreased food intake...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678994/can-exercise-delay-transition-to-active-therapy-in-men-with-low-grade-prostate-cancer-a-multicentre-randomised-controlled-trial
#17
Daniel A Galvão, Dickon Hayne, Mark Frydenberg, Suzanne K Chambers, Dennis R Taaffe, Nigel Spry, Paul A Scuffham, Robert S Ware, Nicolas H Hart, Robert U Newton
INTRODUCTION: Active surveillance is a strategy for managing low-risk, localised prostate cancer, where men are observed with serial prostate-specific antigen assessments to identify signs of disease progression. Currently, there are no strategies to support active surveillance compliance nor are there interventions that can prevent or slow disease progression, ultimately delaying transition to active treatment before it is clinically required. Recently, we proposed that exercise may have a therapeutic potential in delaying the need for active treatment in men on active surveillance...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678879/potassium-is-a-trigger-for-conformational-change-in-the-fusion-spike-of-an-enveloped-rna-virus
#18
Emma K Punch, Samantha Hover, Henry Tw Blest, Jack Fuller, Roger Hewson, Juan Fontana, Jamel Mankouri, John N Barr
Many enveloped viruses enter cells through the endocytic network, from which they must subsequently escape through fusion of viral and endosomal membranes. This membrane fusion is mediated by virus-encoded spikes that respond to the changing endosomal environment, which triggers conformational change in the spike that initiate the fusion process. Several fusion triggers have been identified and include pH, membrane composition and endosome-resident proteins and these cues dictate when and where viral fusion occurs...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29678806/a-novel-algorithm-for-determining-the-contextual-characteristics-of-movement-behaviors-by-combining-accelerometer-features-and-wireless-beacons-development-and-implementation
#19
Daniele Magistro, Salvatore Sessa, Andrew P Kingsnorth, Adam Loveday, Alessandro Simeone, Massimiliano Zecca, Dale W Esliger
BACKGROUND: Unfortunately, global efforts to promote "how much" physical activity people should be undertaking have been largely unsuccessful. Given the difficulty of achieving a sustained lifestyle behavior change, many scientists are reexamining their approaches. One such approach is to focus on understanding the context of the lifestyle behavior (ie, where, when, and with whom) with a view to identifying promising intervention targets. OBJECTIVE: The aim of this study was to develop and implement an innovative algorithm to determine "where" physical activity occurs using proximity sensors coupled with a widely used physical activity monitor...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678786/fetal-bovine-serum-induces-sustained-but-reversible-epithelial-mesenchymal-transition-in-the-beas-2b-cell-line
#20
S W Malm, E A Amouzougan, W T Klimecki
BEAS-2B is a non-malignant, immortalized human cell line that has been used extensively as a model of lung epithelium. Despite ATCC recommendations to culture BEAS-2B in defined, serum-free media, many publications describe culturing BEAS-2B in fetal bovine serum (FBS)-containing media. The objective of this study was to define the effects of FBS on BEAS-2B cells. FBS exposure resulted in increased nuclear levels of transcription factors responsible for regulating epithelial-mesenchymal transition (EMT), increased cell invasiveness and increased anchorage-independent growth...
April 17, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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