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https://www.readbyqxmd.com/read/29054101/virtual-simulated-care-coordination-rounds-for-nursing-students
#1
Donna M Badowski
Implementation of the Affordable Care Act has nursing education reflecting on paradigm shifts in order to prepare nursing students for the evolving health care environment. The traditional focus of nursing education on nursing care in acute care settings does not provide learning experiences in care coordination and transitional care management skills. Virtual simulated care coordination rounds, using the National League for Nursing Advancing Care Excellence resources, offer nursing students an innovative experience in care coordination and transition care management...
November 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29054097/dynamic-characteristics-of-a-flagellar-motor-protein-analyzed-using-an-elastic-network-model
#2
Moon-Ki Choi, Soojin Jo, Byung Ho Lee, Min Hyeok Kim, Jae Boong Choi, Kyunghoon Kim, Moon Ki Kim
At the base of a flagellar motor, its rotational direction and speed are regulated by the interaction between rotor and stator proteins. A switching event occurs when the cytoplasmic rotor protein, called C-ring, changes its conformation in response to binding of the CheY signal protein. The C-ring structure consists of FliG, FliM, and FliN proteins and its conformational changes in FliM and FliG including HelixMC play an important role in switching the motor direction. Therefore, clarifying their dynamic properties as well as conformational changes is a key to understanding the switching mechanism of the motor protein...
October 5, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29053988/intermedin-reduces-neointima-formation-by-regulating-vascular-smooth-muscle-cell-phenotype-via-camp-pka-pathway
#3
Qing Zhu, Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Jin-Ling Ren, Di Wu, Yao Chen, Lin-Shuang Zhang, Yan-Rong Yu, Chao-Shu Tang, Yong-Fen Qi
BACKGROUND AND AIMS: Vascular smooth muscle cell (VSMC) dedifferentiation contributes to neointima formation, which results in various vascular disorders. Intermedin (IMD), a cardiovascular paracrine/autocrine polypeptide, is involved in maintaining circulatory homeostasis. However, whether IMD protects against neointima formation remains largely unknown. The purpose of this study is to investigate the role of IMD in neointima formation and the possible mechanism. METHODS: IMD1-53 (100ng/kg/h) or saline water was used on rat carotid-artery balloon-injury model...
October 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29053744/transition-to-reconstructibility-in-weakly-coupled-networks
#4
Benedict J Lünsmann, Christoph Kirst, Marc Timme
Across scientific disciplines, thresholded pairwise measures of statistical dependence between time series are taken as proxies for the interactions between the dynamical units of a network. Yet such correlation measures often fail to reflect the underlying physical interactions accurately. Here we systematically study the problem of reconstructing direct physical interaction networks from thresholding correlations. We explicate how local common cause and relay structures, heterogeneous in-degrees and non-local structural properties of the network generally hinder reconstructibility...
2017: PloS One
https://www.readbyqxmd.com/read/29053710/early-levallois-and-the-beginning-of-the-middle-paleolithic-in-central-italy
#5
Sylvain Soriano, Paola Villa
In the second half of the 19th century Pleistocene faunas were discovered in two sites, Sedia del Diavolo and Monte delle Gioie, contained in deposits of the Aniene River in the area of Rome (Latium, Italy). Fieldwork by A.C. Blanc in the late 1930's proved the association of fauna and lithic industry within fluvial deposits interbedded with volcanoclastic layers. A human femoral diaphysis and a metatarsal were later identified in the faunal assemblage from Sedia del Diavolo and evaluated as Neandertal. The lithic assemblages from these two sites were the basis of the definition of the Protopontinian by M...
2017: PloS One
https://www.readbyqxmd.com/read/29053547/primary-cutaneous-sarcomatoid-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-with-linear-distributional-lesions
#6
Hao Chen, Jing-Shu Xiong, Nan Sheng, Wen-Kai Zong, Yi-Hua Wang, Min Li, Jian-Fang Sun
We report a case of cutaneous anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALCL) with linear distributional lesions and sarcomatoid histologic features. A sarcomatoid variant is the rarest morphological pattern of ALCL. Interestingly, the morphology of tumor cells in the present case transitioned from a sarcomatoid variant of ALCL at first diagnosis to a classic variant at relapse. The case is a diagnostic challenge considering both the clinical and histologic aspects. Awareness of the sarcomatoid variant of ALCL and its morphological changes can lead to a correct diagnosis...
November 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29053532/using-a-complex-patient-management-scenario-to-help-bridge-the-education-practice-gap
#7
Adriane Burgess, Hannah Murphy Buc, Janice M Brennan
Preparing nursing students for transition to practice is challenging in light of the increasing complexity of today's health care environment. A clinical simulation was developed to engage senior-level bachelor of science in nursing students in the management of a critically ill patient whose deterioration warranted timely transfer to an intensive care unit. In this fast-paced, highly charged simulation, students were challenged to implement priority setting, delegation, communication methods, and teamwork...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053518/role-of-homeodomain-interacting-protein-kinase-2-in-the-pathogenesis-of-tissue-fibrosis-in-keloid-derived-keratinocytes
#8
Yi-Xuan Zhao, Guo-You Zhang, An-Yuan Wang, Ya-Hong Chen, Da-Mu Lin, Qing-Feng Li
Epithelial-mesenchymal transition (EMT) plays a critical role in fibrotic keloid formation, which is characterized by excessive collagen and extracellular matrix synthesis and deposition. Growing evidence suggests that the serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) acts upstream of several major fibrosis signaling pathways; however, the role of HIPK2 in the keloid fibrogenesis remains unknown. In the current study, we investigated the roles of HIPK2 in the pathogenesis of keloids...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053477/revisiting-local-structural-changes-in-geo2-glass-at-high-pressure
#9
Juncai Dong, Hurong Yao, Zhiying Guo, Quanjie Jia, Yan Wang, Pengfei An, Yu Gong, Yaxiang Liang, Dongliang Chen
Despite the great importance in fundamental and industrial fields, understanding structural changes for pressure-induced polyamorphism in network-forming glasses remains a formidable challenge. Here, we revisited the local structural transformations in GeO2 glass up to 54 GPa using x-ray absorption fine structure (XAFS) spectroscopy via a combination diamond anvil cell and polycapillary half-lens. Three polyamorphic transitions can be clearly identified by XAFS structure refinement. First, a progressive increase of the nearest Ge-O distance and bond disorder to a maximum at ~5-16 GPa, in the same pressure region of previously observed tetrahedral-octahedral transformation...
October 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29053398/the-involvement-of-lncrnas-in-the-development-and-progression-of-pancreatic-cancer
#10
Li Duguang, He Jin, Qian Xiaowei, Xu Peng, Wang Xiaodong, Li Zhennan, Qian Jianjun, Yao Jie
Pancreatic cancer is one of the most malignant tumors that are difficult to diagnose at its early stage and there is no effective therapy. Recent studies uncovered that many non-protein-coding RNAs including the class of long noncoding RNAs (lncRNAs) are differentially expressed in various types of tumors and they are potent regulators of tumor progression and metastasis. LncRNA can mediate tumor initiation, proliferation, migration and metastasis through modulating epigenetic modification, alternative splicing, transcription, and protein translation...
October 20, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29053396/embryonic-stem-cell-secreted-factors-decrease-invasiveness-of-triple-negative-breast-cancer-cells-through-regulome-modulation
#11
Elizabeth Tarasewicz, Robert S Oakes, Misael O Aviles, Joelle Straehla, Kathryn M Chilton, Joseph T Decker, Jia Wu, Lonnie D Shea, Jacqueline S Jeruss
Stem cell microenvironments decrease the invasiveness of cancer cells, and elucidating the mechanisms associated with disease regression could further the development of targeted therapies for aggressive cancer subtypes. To this end, we applied an emerging technology, TRanscriptional Activity CEll aRray (TRACER), to investigate the reprogramming of triple-negative breast cancer (TNBC) cells in conditions that promoted a less aggressive phenotype. The repressive environment was established through exposure to mouse embryonic stem cell conditioned media (mESC CM)...
October 20, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29053388/some-chemotherapeutics-treated-colon-cancer-cells-display-a-specific-phenotype-being-a-combination-of-stem-like-and-senescent-cell-features
#12
H Was, J Czarnecka, A Kowalczyk, K Barszcz, T Bernas, K Piwocka, B Kaminska
Colorectal cancer (CRC) is the second leading cause of death among cancer patients in the Northern countries. CRC can reappear a long time after treatment. Recent clinical studies demonstrated that, in response to chemotherapy, cancer cells may undergo stress-induced premature senescence (SIPS), which typically results in growth arrest. Nonetheless, these senescent cells were reported to divide in an atypical manner and thus contribute to cancer re-growth. Therefore, we examined if SIPS escape may follow treatment with chemotherapeutics used clinically: 5-fluorouracil (5-FU), oxaliplatin (OXA) and irinotecan (IRINO)...
October 20, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29053334/topological-phase-transitions-in-the-photonic-spin-hall-effect
#13
W J M Kort-Kamp
The recent synthesis of two-dimensional staggered materials opens up burgeoning opportunities to study optical spin-orbit interactions in semiconducting Dirac-like systems. We unveil topological phase transitions in the photonic spin Hall effect in the graphene family materials. It is shown that an external static electric field and a high frequency circularly polarized laser allow for active on-demand manipulation of electromagnetic beam shifts. The spin Hall effect of light presents a rich dependence with radiation degrees of freedom, and material properties, and features nontrivial topological properties...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053333/spin-resonance-clock-transition-of-the-endohedral-fullerene-15-n-c_-60
#14
R T Harding, S Zhou, J Zhou, T Lindvall, W K Myers, A Ardavan, G A D Briggs, K Porfyrakis, E A Laird
The endohedral fullerene ^{15}N@C_{60} has narrow electron paramagnetic resonance lines which have been proposed as the basis for a condensed-matter portable atomic clock. We measure the low-frequency spectrum of this molecule, identifying and characterizing a clock transition at which the frequency becomes insensitive to magnetic field. We infer a linewidth at the clock field of 100 kHz. Using experimental data, we are able to place a bound on the clock's projected frequency stability. We discuss ways to improve the frequency stability to be competitive with existing miniature clocks...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053328/qcd-electroweak-first-order-phase-transition-in-a-supercooled-universe
#15
Satoshi Iso, Pasquale D Serpico, Kengo Shimada
If the electroweak sector of the standard model is described by classically conformal dynamics, the early Universe evolution can be substantially altered. It is already known that-contrarily to the standard model case-a first-order electroweak phase transition may occur. Here we show that, depending on the model parameters, a dramatically different scenario may happen: A first-order, six massless quark QCD phase transition occurs first, which then triggers the electroweak symmetry breaking. We derive the necessary conditions for this dynamics to occur, using the specific example of the classically conformal B-L model...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053323/when-the-hotter-cools-more-quickly-mpemba-effect-in-granular-fluids
#16
Antonio Lasanta, Francisco Vega Reyes, Antonio Prados, Andrés Santos
Under certain conditions, two samples of fluid at different initial temperatures present a counterintuitive behavior known as the Mpemba effect: it is the hotter system that cools sooner. Here, we show that the Mpemba effect is present in granular fluids, both in uniformly heated and in freely cooling systems. In both cases, the system remains homogeneous, and no phase transition is present. Analytical quantitative predictions are given for how differently the system must be initially prepared to observe the Mpemba effect, the theoretical predictions being confirmed by both molecular dynamics and Monte Carlo simulations...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053320/interplay-between-process-zone-and-material-heterogeneities-for-dynamic-cracks
#17
Fabian Barras, Philippe H Geubelle, Jean-François Molinari
Using an elastodynamic boundary integral formulation coupled with a cohesive model, we study the problem of a dynamic rupture front propagating along an heterogeneous plane. We show that small-scale heterogeneities facilitate the supershear transition of a mode-II crack. The elastic pulses radiated during front accelerations explain how microscopic variations of fracture toughness change the macroscopic rupture dynamics. Perturbations of dynamic fronts are then systematically studied with different microstructures and loading conditions...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053315/shear-modulus-and-shear-stress-fluctuations-in-polymer-glasses
#18
I Kriuchevskyi, J P Wittmer, H Meyer, J Baschnagel
Using molecular dynamics simulation of a standard coarse-grained polymer glass model, we investigate by means of the stress-fluctuation formalism the shear modulus μ as a function of temperature T and sampling time Δt. While the ensemble-averaged modulus μ(T) is found to decrease continuously for all Δt sampled, its standard deviation δμ(T) is nonmonotonic, with a striking peak at the glass transition. Confirming the effective time-translational invariance of our systems, μ(Δt) can be understood using a weighted integral over the shear-stress relaxation modulus G(t)...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053312/topological-transitions-and-fractional-charges-induced-by-strain-and-a-magnetic-field-in-carbon-nanotubes
#19
Yonathan Efroni, Shahal Ilani, Erez Berg
We show that carbon nanotubes (CNT) can be driven through a topological phase transition using either strain or a magnetic field. This can naturally lead to Jackiw-Rebbi soliton states carrying fractionalized charges, similar to those found in a domain wall in the Su-Schrieffer-Heeger model, in a setup with a spatially inhomogeneous strain and an axial field. Two types of fractionalized states can be formed at the interface between regions with different strain: a spin-charge separated state with integer charge and spin zero (or zero charge and spin ±ℏ/2), and a state with charge ±e/2 and spin ±ℏ/4...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053310/local-pore-size-correlations-determine-flow-distributions-in-porous-media
#20
Karen Alim, Shima Parsa, David A Weitz, Michael P Brenner
The relationship between the microstructure of a porous medium and the observed flow distribution is still a puzzle. We resolve it with an analytical model, where the local correlations between adjacent pores, which determine the distribution of flows propagated from one pore downstream, predict the flow distribution. Numerical simulations of a two-dimensional porous medium verify the model and clearly show the transition of flow distributions from δ-function-like via Gaussians to exponential with increasing disorder...
October 6, 2017: Physical Review Letters
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