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https://www.readbyqxmd.com/read/28538804/transitional-metaplasia-in-intestinal-epithelium-of-rats-submitted-to-intestinal-cystoplasty-and-treatment-with-l-lysine
#1
Alessandra Marques Dos Santos, Joao Paulo Ferreira Coelho, Camila de Carvalho Juanes, Rafael Barbosa de Azevedo, Clara Araujo Diniz, Francisco Vagnaldo Fechine Jamacaru, Conceição Aparecida Dornelas
Purpose: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks. Results: On histopathology with hematoxylin and eosin, mild to moderate hyperplasia transitional was observed in at the site of anastomosis in all animals submitted to cystoplasty (Groups A and B), but "transitional metaplasia" of the intestinal glandular epithelium was more accentuated in Group A (p=0...
April 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28538690/dysregulation-of-mirna-expression-in-cancer-associated-fibroblasts-cafs-and-its-consequences-on-the-tumor-microenvironment
#2
REVIEW
Maren Schoepp, Anda Jana Ströse, Jörg Haier
The tumor microenvironment, including cancer-associated fibroblasts (CAF), has developed as an important target for understanding tumor progression, clinical prognosis and treatment responses of cancer. Cancer cells appear to transform normal fibroblasts (NF) into CAFs involving direct cell-cell communication and epigenetic regulations. This review summarizes the current understanding on miR involvement in cancer cell-tumor environment/stroma communication, transformation of NFs into CAFs, their involved targets and signaling pathways in these interactions; and clinical relevance of CAF-related miR expression profiles...
May 24, 2017: Cancers
https://www.readbyqxmd.com/read/28538591/intrathecal-morphine-and-oral-analgesics-provide-safe-and-effective-pain-control-after-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#3
Ying Li, Rebecca A Hong, Christopher B Robbins, Kathleen M Gibbons, Ashlee E Holman, Michelle S Caird, Frances A Farley, Matthew D Abbott, Michelle C Burke
STUDY DESIGN: Retrospective comparative study. OBJECTIVE: To demonstrate that intrathecal morphine (ITM) and oral analgesics provide effective pain control after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS), and this protocol has a low complication rate so patients can be admitted to a general care floor. SUMMARY OF BACKGROUND DATA: Previous studies have shown that ITM combined with intravenous patient-controlled analgesia or epidural infusion (EPI) provides effective pain control after PSF for AIS...
May 23, 2017: Spine
https://www.readbyqxmd.com/read/28538566/predicting-thrombosis-formation-in-1-mm-diameter-arterial-anastomoses-with-transit-time-ultrasound-technology
#4
Gabrielle Shaughness, Collin Blackburn, Alberto Ballestín, Yelena Akelina, Jeffrey A Ascherman
BACKGROUND: Thrombosis is a common source of failure in anastomoses, flaps, and vascular grafts. Ensuring vessel patency is critical to the success of microvascular procedures. Any tool that can accurately predict the patency of an anastomosis intraoperatively would enable the surgeon to detect and correct flow restrictions while the patient is still in the operating room. METHODS: The authors used transit-time ultrasound technology in this pilot study to investigate whether a minimal cutoff value for quantitative postoperative blood flow (in milliliters per minute) could be established that would reliably predict sustained vessel patency at 24 hours postoperatively...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538351/care-transitions-among-medicare-beneficiaries-at-the-end-of-life
#5
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Nursing
https://www.readbyqxmd.com/read/28538340/physical-therapy-for-a-child-with-infantile-idiopathic-scoliosis-and-motor-delay
#6
Rhea K Hall, Mary Jane Rapport
PURPOSE: The purpose of this case report is to describe physical therapy (PT) for a child with infantile idiopathic scoliosis and motor delay. KEY POINTS: A 10-month-old boy with a 28° left thoracolumbar scoliosis was referred for PT and was seen weekly in his home over a 6-month period following a diagnosis of scoliosis and delayed gross motor milestones. Before the initiation of PT, the child was scheduled to undergo serial casting for correction of the spinal curve and was not yet rolling or transitioning in or out of sitting...
May 19, 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28538287/cost-utility-analysis-of-reconstruction-compared-with-primary-amputation-for-patients-with-severe-lower-limb-trauma-in-colombia
#7
Mateo Ceballos, Carlos Oliver Valderrama, Luis Esteban Orozco, Laura Sánchez, Juan Pablo Valderrama, Luz Helena Lugo
BACKGROUND: To establish, from the health system perspective, the cost-utility relationship of limb reconstruction compared with primary amputation for patients over 32 years with grade IIIB and IIIC severe lower limb trauma in Colombia, S.A. METHODS: A Markov model was built including different short-term and long-term states that represent the main events that a patient could experience after a lower limb amputation or a reconstruction. A 42-year time horizon was considered for the base case...
May 17, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538179/hand2-target-gene-regulatory-networks-control-atrioventricular-canal-and-cardiac-valve-development
#8
Frédéric Laurent, Ausra Girdziusaite, Julie Gamart, Iros Barozzi, Marco Osterwalder, Jennifer A Akiyama, Joy Lincoln, Javier Lopez-Rios, Axel Visel, Aimée Zuniga, Rolf Zeller
The HAND2 transcriptional regulator controls cardiac development, and we uncover additional essential functions in the endothelial to mesenchymal transition (EMT) underlying cardiac cushion development in the atrioventricular canal (AVC). In Hand2-deficient mouse embryos, the EMT underlying AVC cardiac cushion formation is disrupted, and we combined ChIP-seq of embryonic hearts with transcriptome analysis of wild-type and mutants AVCs to identify the functionally relevant HAND2 target genes. The HAND2 target gene regulatory network (GRN) includes most genes with known functions in EMT processes and AVC cardiac cushion formation...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28538166/an-evolutionary-perspective-on-plasmid-lifestyle-modes
#9
REVIEW
Nils Hülter, Judith Ilhan, Tanita Wein, A Samer Kadibalban, Katrin Hammerschmidt, Tal Dagan
Plasmids are extra-chromosomal genetic elements whose ecology and evolution depend on their genetic repertoire and interaction with the host. We review the events that lead to transitions between plasmid lifestyle modes - invasion, host range, plasmid persistence and adaptation - from a plasmid perspective. Plasmid lifestyle is determined by various traits, including mobility, stability and indispensability that vary in their magnitude. Transitions between the plasmid lifestyles, invasion, host range, plasmid persistence and adpatation, are caused by the interplay between plasmid traits and host biology...
May 21, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28538098/two-dimensional-metal-organic-framework-nanosheets-as-an-enzyme-inhibitor-modulation-of-the-%C3%AE-chymotrypsin-activity
#10
Ming Xu, Shuai Yuan, Xin-Yu Chen, Yu-Jie Chang, Gregory Steven Day, Zhi-Yuan Gu, Hong-Cai Zhou
Two-dimensional metal-organic framework (MOF) nanosheets are utilized as effective enzyme inhibitors, providing an in-spiring means to enhance the control of cellular processes as well as improve our understanding of the surface chemistry between MOFs and enzymes. In this paper, we demonstrated that the activity of α-Chymotrypsin (ChT) can be effectively inhibited with 96.9% inhibition by the 2-D Cu(bpy)2(OTf)2 nanosheets, while the other Zn2(bim)4 nanosheets show no significant inhibition effect towards ChT...
May 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28537944/behavioural-responses-of-zebrafish-larvae-to-acute-ethosuximide-exposure
#11
Yongxia Ji, Jia Lin, Xiaolan Peng, Xiuyun Liu, Fei Li, Yinglan Zhang, Ning Guo, Qiang Li
The anticonvulsant drug ethosuximide has shown diverse anxiety-related activity in rodents, but research in zebrafish is limited. To evaluate the effects of acute ethosuximide exposure on locomotor activity and anxiety-related thigmotaxis behaviours of zebrafish larvae, the activity of AB strain zebrafish larvae at 5 and 7 days postfertilization (dpf) was analysed under normal constant illumination and stressful light-dark transitions. Under constant illumination, ethosuximide at concentrations of 2, 5 and 10 mmol/l increased the distances travelled and intensified locomotor responses to a novel environment...
May 19, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28537853/dermatology-discharge-continuity-clinic-enhances-resident-autonomy-and-insight-into-transitions-of-care-competencies-a-cross-sectional-survey-study
#12
Jasmine Rana, Arash Mostaghimi
Dermatology residents perform consults on hospitalized patients, but are often limited in their ability to follow-up with these patients after discharge, leading to inadequate follow-up and understanding of post-discharge transitions of care. In 2013, a discharge continuity clinic (DCC) staffed by the inpatient consult dermatology resident and attending dermatologist was established at one of the four adult hospital sites residents rotate through in the Harvard Combined Dermatology Residency Program. Resident perceptions about the DCC and their educational experience on inpatient consult rotations with a DCC and without a DCC were obtained using a cross-sectional survey instrument in June 2016...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28537766/pirfenidone-induces-g1-arrest-in-human-tenon-s-fibroblasts-in-vitro-involving-akt-and-mapk-signaling-pathways
#13
Xiujuan Guo, Yangfan Yang, Liling Liu, Xiaoan Liu, Jiangang Xu, Kaili Wu, Minbin Yu
PURPOSE: To investigate the underlying mechanism by which pirfenidone blocks the transition from the G1 to S phase in primary human Tenon's fibroblasts. METHODS: Primary human Tenon's fibroblasts were characterized by immunocytofluorescence staining with vimentin, fibroblast surface protein, and cytokeratin. After treating Tenon's fibroblasts with pirfenidone under proliferation conditions (10% fetal bovine serum), cell proliferation was measured using a WST-1 assay...
May 24, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28537749/water-microsolvation-can-switch-the-binding-mode-of-ni-ii-with-small-peptides
#14
Robert C Dunbar, Jonathan Martens, Giel Berden, Jos Oomens
Ni(II) ions can be caged by surrounding peptide ligands in two basic binding patterns: the "iminol" (IM) binding pattern, where chelation occurs by deprotonated amide nitrogens, or the charge-solvated (CS) binding pattern, where chelation occurs by amide carbonyl oxygens. Gas-phase observation may clarify the factors affecting this choice in solution and in peptide and protein matrices. Infrared-spectroscopic determination of gas-phase structures shows here how microsolvation by just one water molecule switches the balance of this choice from IM to CS for the Ni2+Gly3 complex, in contrast to the always-CS structure of the Ni2+Gly4 complex...
May 24, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28537747/examination-of-the-mechanism-of-the-yield-of-n2o-from-nitroxyl-hno-in-the-solution-phase-by-theoretical-calculations
#15
Kaiqiang Zhang, Stefan T Thynell
The dimerization of HNO and subsequent yield of N2O in aqueous solution are studied based on the theoretical calculations and kinetic simulations. The initial dimerization reactions were computed at various levels of theory and large divergence was observed in the predictions of the gas-phase free energies. The T1 diagnostics at CCSD(T)/aug-cc-pVTZ suggests multireference characteristics of the HNO dimers and the transition states. The solution-phase free energies were obtained using the wB97XD method and the SMD solvation model...
May 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28537739/modeling-the-effect-of-polymer-chain-stiffness-on-the-behavior-of-polymer-nanocomposites
#16
José Javier Burgos-Mármol, Óscar Álvarez-Machancoses, Alessandro Patti
Due to their central role in industrial formulations spanning from food packaging to smart coatings, polymer nanocomposites have been the object of a remarkable attention over the last two decades. Incorporating nanoparticles (NPs) to a polymer matrix modifies the conformation and mobility of the polymer chains at the NP-polymer interface and can potentially provide materials with enhanced properties as compared to pristine polymers. To this end, it is crucial to predict and control the ability of NPs to diffuse and achieve a good dispersion in the polymer matrix...
May 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28537725/the-color-of-cation-%C3%AF-interactions-subtleties-of-amine-tryptophan-interaction-energetics-allow-for-radical-like-visible-absorbance-and-fluorescence
#17
Laura J Juszczak, Azaria S Eisenberg
Several peptides and a protein with an inter- or intramolecular cation-π interaction between tryptophan (Trp) and an amine cation are shown to absorb and fluoresce in the visible region of the spectrum. Titration of indole with sodium hydroxide or ammonium hydroxide yields an increasing visible fluorescence as well. Visible absorption and multi-peaked fluorescence excitation spectra correlate with experimental absorption spectra and the vibrational modes of calculated absorption spectra for the neutral Trp radical...
May 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28537691/the-influence-of-previous-robotic-experience-in-the-initial-learning-curve-of-laparoscopic-radical-prostatectomy
#18
José Anastácio Dias, Marcos F Dall'oglio, João Roberto Colombo, Rafael F Coelho, William Carlos Nahas
INTRODUCTION: This study analyzed the impact of the experience with Robotic-Assisted Laparoscopic Prostatectomy (RALP) on the initial experience with Laparoscopic Radical Prostatectomy (LRP) by examining perioperative results and early outcomes of 110 patients. LRPs were performed by two ro-botic fellowship trained surgeons with daily practice in RALP. PATIENTS AND METHODS: 110 LRP were performed to treat aleatory selected patients. The patients were divided into 4 groups for prospective analyses...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28535599/monitoring-spatiotemporal-variations-in-nutrients-in-a-large-drinking-water-reservoir-and-their-relationships-with-hydrological-and-meteorological-conditions-based-on-landsat-8-imagery
#19
Yuan Li, Yunlin Zhang, Kun Shi, Guangwei Zhu, Yongqiang Zhou, Yibo Zhang, Yulong Guo
Nutrient enrichment is a major cause of water eutrophication, and variations in nutrient enrichment are influenced by environmental changes and anthropogenic activities. Accurately estimating nutrient concentrations and understanding their relationships with environmental factors are vital to develop nutrient management strategies to mitigate eutrophication. Landsat 8 Operational Land Imager (OLI) data is used to estimate nutrient concentrations and analyze their responses to hydrological and meteorological conditions...
May 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28535548/is-traumatic-and-non-traumatic-neck-pain-associated-with-brain-alterations-a-systematic-review
#20
Robby DePauw, Iris Coppieters, Mira Meeus, Karen Caeyenberghs, Lieven Danneels, Barbara Cagnie
BACKGROUND: Chronic neck pain affects 50% - 85% of people who have experienced an acute episode. This transition and the persistence of chronic complaints are believed to be mediated by brain alterations among different central mechanisms. OBJECTIVES: This study aimed to systematically review and critically appraise the current existing evidence regarding structural and functional brain alterations in patients with whiplash associated disorders (WAD) and idiopathic neck pain (INP)...
May 2017: Pain Physician
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