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https://www.readbyqxmd.com/read/29471538/novel-roles-of-ascorbate-in-plants-induction-of-cytosolic-ca2-signals-and-efflux-from-cells-via-anion-channels
#1
M Makavitskaya, D Svistunenko, I Navaselsky, P Hryvusevich, V Mackievic, C Rabadanova, E Tyutereva, V Samokhina, D Straltsova, A Sokolik, O Voitsekhovskaja, V Demidchik
Ascorbate is not often considered as a signalling molecule in plants. This study demonstrates that, in Arabidopsis roots, exogenous L-ascorbic acid triggers a transient increase of the cytosolic free calcium activity ([Ca2+]cyt.) that is central to plant signalling. Exogenous copper and iron stimulates the ascorbate-induced [Ca2+]cyt. elevation while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators and removal of the cell wall inhibit this reaction. These data show that apoplastic redox-active transition metals are involved in the ascorbate-induced [Ca2+]cyt...
February 17, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29471502/elevated-g6pd-expression-contributes-to-migration-and-invasion-of-hepatocellular-carcinoma-cells-by-inducing-epithelial-mesenchymal-transition
#2
Ming Lu, Lu Lu, Qiongzhu Dong, Guangyang Yu, Jinhong Chen, Lunxiu Qin, Lianxin Wang, Wenwei Zhu, Huliang Jia
Altered metabolism is one of the hallmarks of cancer cells. Pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is elevated in many cancers and contributes to tumor growth by producing ribose-5-phosphate and NADPH through PPP. However, the role of G6PD in hepatocellular carcinoma (HCC) metastasis and the clinical significance of G6PD in HCC progression and prognosis have not been well determined. In this study, by investigating tissue samples from HCC patients and HCC cell lines, we found that elevated G6PD expression is significantly associated with HCC metastasis and poor prognosis of HCCs, and that knockdown of G6PD inhibits in vitro proliferation, migration and invasion of HCC cell lines...
February 17, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29471473/bidirectional-gpr119-agonism-requires-peptide-yy-and-glucose-for-activity-in-mouse-and-human-colon-mucosa
#3
Iain R Tough, Sarah Forbes, Herbert Herzog, Robert M Jones, Thue W Schwartz, Helen M Cox
The lipid sensor GPR119 is highly expressed by enteroendocrine L-cells and pancreatic β-cells that release the hormones, PYY and GLP-1, and insulin, respectively. Endogenous oleoylethanolamide (OEA) and the dietary metabolite, 2-monoacylglycerol (2-OG) can each activate GPR119. Here we compared mucosal responses to selective, synthetic GPR119 agonists (AR440006, AR231453) and the lipids, OEA, 2-OG and N-oleoyldopamine (OLDA) monitoring epithelial ion transport as a read-out for L-cell activity in native mouse and human gastrointestinal (GI) mucosae...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471419/true-lumen-and-false-lumen-diameter-changes-in-the-downstream-aorta-after-frozen-elephant-trunk-implantation
#4
Tim Berger, Maximilian Kreibich, Julia Morlock, Stoyan Kondov, Johannes Scheumann, Fabian A Kari, Bartosz Rylski, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
OBJECTIVES: To evaluate early and mid-term clinical outcomes and to assess the potential of the frozen elephant trunk technique to induce remodelling of downstream aortic segments in acute and chronic thoracic aortic dissections. METHODS: Over a 4-year period, 65 patients (48 men, aged 61 ± 12 years) underwent total aortic arch replacement using the frozen elephant trunk technique for acute (n = 31) and chronic (n = 34) thoracic aortic dissections at our institution...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471370/competitive-ability-of-capsella-species-with-different-mating-systems-and-ploidy-levels
#5
Sandra Petrone Mendoza, Martin Lascoux, Sylvain Glémin
Background and Aims: Capsella is a model genus for studying the transition from outcrossing to selfing, with or without change in ploidy levels. The genomic consequences and changes in reproductive traits (selfing syndrome) associated with these shifts have been studied in depth. However, potential ecological divergence among species of the genus has not been determined. Among ecological traits, competitive ability could be relevant for selfing evolution, as selfing has been shown to be statistically associated with reduced competitiveness in a recent meta-analysis...
February 17, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29471363/proteome-analysis-of-an-m-avium-mutant-exposes-a-novel-role-of-the-bifunctional-protein-lysx-in-regulation-of-metabolic-activity
#6
Greana Kirubakar, Jayaseelan Murugaiyan, Christoph Schaudinn, Flavia Dematheis, Gudrun Holland, Murat Eravci, Christoph Weise, Uwe Roesler, Astrid Lewin
Lysyl-phosphatidylglycerol (L-PG) is one of the components of the mycobacterial membrane which contributes to the resistance towards cationic antimicrobial peptides, a host-induced frontline defense against invading pathogens. Its production is catalyzed by LysX, a bifunctional protein with lysyl transferase and lysyl-tRNA synthetase activity. Comparative proteome analysis of a lysX mutant of M. avium strain104 and the wild type indicated that the lysX mutant strain undergoes a transition in phenotype by switching the carbon metabolism to β-oxidation of fatty acids along with accumulation of lipid inclusions...
February 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29471362/changes-in-hospital-bond-ratings-after-the-transition-to-a-new-electronic-health-record
#7
Dustin McEvoy, Michael L Barnett, Dean F Sittig, Skye Aaron, Ateev Mehrotra, Adam Wright
Objective: To assess the impact of electronic health record (EHR) implementation on hospital finances. Materials and Methods: We analyzed the impact of EHR implementation on bond ratings and net income from service to patients (NISP) at 32 hospitals that recently implemented a new EHR and a set of controls. Results: After implementing an EHR, 7 hospitals had a bond downgrade, 7 had a bond upgrade, and 18 had no changes. There was no difference in the likelihood of bond rating changes or in changes to NISP following EHR go-live when compared to control hospitals...
February 20, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29471338/transitioning-from-river-blindness-control-to-elimination-steps-toward-stopping-treatment
#8
Paul T Cantey, Sharon L Roy, Daniel Boakye, Upendo Mwingira, Eric A Ottesen, Adrian D Hopkins, Yao K Sodahlon
The transition from onchocerciasis control to elimination requires country programmes to rethink their approach to a variety of activities as they move from addressing morbidity to addressing transmission of the parasite. Although the 2016 WHO guidelines provide extensive recommendations, it was beyond the scope of the document to provide guidance on all aspects of the transition. This paper will discuss some of the important issues that programmes are grappling with as they transition to elimination and provide some potential approaches that programmes can use to address them...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29471320/cover-crop-species-and-management-influence-predatory-arthropods-and-predation-in-an-organically-managed-reduced-tillage-cropping-system
#9
Ariel N Rivers, Christina A Mullen, Mary E Barbercheck
Agricultural practices affect arthropod communities and, therefore, have the potential to influence the activities of arthropods. We evaluated the effect of cover crop species and termination timing on the activity of ground-dwelling predatory arthropods in a corn-soybean-wheat rotation in transition to organic production in Pennsylvania, United States. We compared two cover crop treatments: 1) hairy vetch (Vicia villosa Roth) planted together with triticale (×Triticosecale Wittmack) after wheat harvest, and 2) cereal rye (Secale cereale Linnaeus) planted after corn harvest...
January 29, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29471243/trps1-suppresses-breast-cancer-epithelial-mesenchymal-transition-program-as-a-negative-regulator-of-suz12
#10
Jing Hu, Peng Su, Meng Jiao, Xinnuo Bai, Mei Qi, Hui Liu, Zhen Wu, Jingtian Sun, Gengyin Zhou, Bo Han
Breast cancer (BC) is among the most common malignant diseases and metastasis is the handcuff of treatment. Cancer metastasis is a multistep process associated with the epithelial-mesenchymal transition (EMT) program. Several studies have demonstrated that transcriptional repressor GATA binding 1 (TRPS1) played important roles in development and progression of primary BC. In this study we sought to identify the mechanisms responsible for this function of TRPS1 in the continuum of the metastatic cascade. Here we described that TRPS1 was significantly associated with BC metastasis using public assessable datasets...
February 19, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29471224/quantification-of-desoxyrhapontigenin-4-methoxyresveratrol-in-rat-plasma-by-lc-ms-ms-application-to-pre-clinical-pharmacokinetic-study
#11
Yu Dai, Amanda Li Cheng Tan, Huan Chen, Pei Shi Ong, Xiaoqiang Xiang, Jinzhu Wu, Hai-Shu Lin
Desoxyrhapontigenin (DRG, 4-methoxyresveratrol or trans-3,5-dihydroxy-4'-methoxystilbene) is a naturally occurring resveratrol (RES) derivative with a variety of biological activities. To facilitate its further medicinal exploration, a reliable LC-MS/MS method was developed and validated for the quantification of DRG in rat plasma using heavy isotope labelled RES as an internal standard. The ESI was operated in its negative ion mode while DRG and RES were determined by multiple reaction monitoring (MRM) using precursor-to-product ion transitions of m/z 241...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29471195/gxnor-net-training-deep-neural-networks-with-ternary-weights-and-activations-without-full-precision-memory-under-a-unified-discretization-framework
#12
Lei Deng, Peng Jiao, Jing Pei, Zhenzhi Wu, Guoqi Li
Although deep neural networks (DNNs) are being a revolutionary power to open up the AI era, the notoriously huge hardware overhead has challenged their applications. Recently, several binary and ternary networks, in which the costly multiply-accumulate operations can be replaced by accumulations or even binary logic operations, make the on-chip training of DNNs quite promising. Therefore there is a pressing need to build an architecture that could subsume these networks under a unified framework that achieves both higher performance and less overhead...
February 2, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29471173/correlating-growth-mechanism-and-morphology-in-cu-tcnq-organometallic-complex-a-microscopic-study
#13
Gopala R Bhadu, Jayesh C Chaudhari, Babulal Rebary, Rajesh Patidar, Divesh N Srivastava
The structure-property correlation in the Cu-TCNQ organometallic complex is very important for explaining its unusual electrical, optical and magnetic properties. Consequently several morphological studies and their correlation with the properties of these materials can be found in the literature, although no systematic study of various morphologies with growth conditions and their correlation has been reported to the best of our knowledge. Therefore in this manuscript the interconversion of various morphologies is reported using electron and probe microscopies...
February 13, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29471141/the-morphological-and-molecular-mechanisms-of-epithelial-endothelial-to-mesenchymal-transition-and-its-involvement-in-atherosclerosis
#14
REVIEW
M Wesseling, T R Sakkers, S C A de Jager, G Pasterkamp, M J Goumans
Cell transdifferentiation occurs during cardiovascular development or remodeling either as a pathologic feature in the progression of disease or as a response to injury. Endothelial-to-Mesenchymal Transition (EndMT) is a process that is classified as a specialized form of Epithelial-to-Mesenchymal Transition (EMT), in which epithelial cells lose their epithelial characteristics and gain a mesenchymal phenotype. During transdifferentiation, cells lose both cell-cell contacts and their attachment to the basement membrane...
February 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29471038/co-delivery-nanoparticle-to-overcome-metastasis-promoted-by-insufficient-chemotherapy
#15
Qing Zhou, Yihui Li, Yanhong Zhu, Chan Yu, Haibo Jia, Binghao Bao, Hang Hu, Chen Xiao, Jianqi Zhang, Xiaofan Zeng, Ying Wan, Huibi Xu, Zifu Li, Xiangliang Yang
Heterogeneous distribution of drug inside tumor is ubiquitous, causing regional insufficient chemotherapy, which might be the hotbed for drug resistance, tumor cell repopulation and metastasis. Herein, we verify, for the first time, that heterogeneous drug distribution induced insufficient chemotherapy would accelerate the process of epithelial mesenchymal transition (EMT), consequently resulting in the promotion of tumor metastasis. To eliminate the insufficient chemotherapy promoted metastasis, we conceived a co-delivery strategy by hydroxyethyl starch-polylactide (HES-PLA) nanoparticle, in which DOX and TGF-β receptor inhibitor, LY2157299 (LY), were administered together...
February 19, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29471009/patterns-induced-by-super-cross-diffusion-in-a-predator-prey-system-with-michaelis-menten-type-harvesting
#16
Biao Liu, Ranchao Wu, Liping Chen
Turing instability and pattern formation in a super cross-diffusion predator-prey system with Michaelis-Menten type predator harvesting are investigated. Stability of equilibrium points is first explored with or without super cross-diffusion. It is found that cross-diffusion could induce instability of equilibria. To further derive the conditions of Turing instability, the linear stability analysis is carried out. From theoretical analysis, note that cross-diffusion is the key mechanism for the formation of spatial patterns...
February 19, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29471001/activated-cxcl5-cxcr2-axis-promotes-the-migration-invasion-and-emt-of-papillary-thyroid-carcinoma-cells-via-modulation-of-%C3%AE-catenin-pathway
#17
Dong Cui, Yongfu Zhao, Jingchao Xu
Initiation of epithelial-to-mesenchymal transition (EMT) is common in papillary thyroid carcinoma (PTC) and may contribute to its metastasis. Aims of the present study are to investigate whether and how the C-X-C motif chemokine ligand (CXCL)-5/C-X-C motif receptor 2 (CXCR2) axis affects PTC metastasis, with a focus on the EMT process. Herein, two PTC cell lines, KTC-1 and B-CPAP cells, identified as CXCR2-positive cells were used as the cell model. We found that a 24-h stimulation of 1 or 10 nM recombinant human CXCL5 (rhCXCL5) enhanced the migration and invasion of both KTC-1 and B-CPAP cells without affecting their proliferation...
February 19, 2018: Biochimie
https://www.readbyqxmd.com/read/29470956/metabolomic-insights-into-the-effects-of-thyroid-hormone-on-rana-lithobates-catesbeiana-metamorphosis-using-whole-body-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging-maldi-msi
#18
Teesha C Luehr, Emily M Koide, Xiaodong Wang, Jun Han, Christoph H Borchers, Caren C Helbing
Anuran metamorphosis involves the transformation of an aquatic tadpole into a juvenile frog. This process is completely dependent upon thyroid hormones (THs). Although much research has been focused on changes in gene expression programs during this postembryonic developmental period, transitions in the metabolic profiles are relatively poorly understood. Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI) is a technique that generates highly multiplexed mass spectra while retaining spatial location information on a thin tissue section...
February 19, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29470848/simultaneous-determination-of-evodiamine-and-its-four-metabolites-in-rat-plasma-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#19
Cuiyun Wang, Fang Yue, Guangfeng Ai, Jie Yang
A simple and sensitive liquid chromatography tandem mass spectrometry method was validated for simultaneous quantification of evodiamine and its metabolites 10-hydroxyevodiamine (M1), 18-hydroxyevodiamine (M2), 10-hydroxyevodiamine-glucuronide (M3) and 18-hydroxy- evodiamine-glucuronide (M4) in rat plasma for the first time. The analytes were extracted with acetonitrile and separated on a C18 column within 3 min. The detection was achieved in positive selected reaction monitoring mode with precursor-to-product transitions at m/z 304...
February 22, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29470842/elucidating-the-nature-of-the-excited-state-of-a-heteroleptic-copper-photosensitizer-using-time-resolved-x-ray-absorption-spectroscopy
#20
Dooshaye Moonshiram, Pablo Garrido-Barros, Carolina Gimbert-Suriñach, Antonio Picon, Cunming Liu, Xiaoyi Zhang, Michael Karnahl, Antoni Llobet
We report the light-induced electronic and geometric changes taking place within a heteroleptic Cu(I) photosensitizer, namely [(xant)Cu(Me2phenPh2)]PF6 (xant = xantphos, Me2phenPh2 = bathocuproine), by time-resolved X-ray absorption spectroscopy in the ps-µs time-regime. Time-resolved X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) analysis enabled the elucidation of the electronic and structural configuration of the copper centre in the excited state as well as its decay dynamics in different solvent conditions with and without triethylamine acting as a sacrificial electron donor...
February 22, 2018: Chemistry: a European Journal
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