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esophageal squamous cell carcinoma

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https://www.readbyqxmd.com/read/29052514/five-fraction-sbrt-for-ultra-central-nsclc-in-field-recurrences-following-high-dose-conventional-radiation
#1
Michael C Repka, Nima Aghdam, Shaan K Kataria, Lloyd Campbell, Simeng Suy, Sean P Collins, Eric Anderson, Jonathan W Lischalk, Brian T Collins
PURPOSE/OBJECTIVE: Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body radiation therapy (SBRT) is a promising modality to achieve reasonable local control, although toxicity remains a concern. MATERIALS/METHODS: Patients previously treated with high-dose CF-EBRT (≥59.4 Gy, ≤3 Gy/fraction) for non-metastatic NSCLC who underwent salvage SBRT for localized ultra-central in-field recurrence were included in this analysis...
October 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29049013/identification-and-validation-of-fibroblast-growth-factor-12-gene-as-a-novel-potential-biomarker-in-esophageal-cancer-using-cancer-genomic-datasets
#2
Ashish Bhushan, Avninder Singh, Sujala Kapur, Bibhuti B Borthakar, Jagannath Sharma, Avdhesh K Rai, Amal C Kataki, Sunita Saxena
Esophageal squamous cell carcinoma (ESCC) has a complex, multifactorial etiology in which environmental, geographical, and genetic factors play major roles. It is the second most common cancer among men and the fourth most common among women in India, with a particularly high prevalence in Northeast India. In this study, an integrative in silico [DAVID, NCG5.0, Oncomine, Cancer Cell Line Encyclopedia, and The Cancer Genome Atlas (TCGA)] approach was used to identify the potential biomarkers by using the available three genomic datasets on ESCC from Northeast India followed by its in vitro functional validation...
October 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29048664/mir-25-promotes-metastasis-via-targeting-fbxw7-in-esophageal-squamous-cell-carcinoma
#3
Ye Hua, Kai Zhao, Gang Tao, Chunhua Dai, Yuting Su
Increasing evidence suggests that miR-25 can function as an oncogene in different types of human malignancies, whereas little is known concerning the role of miR-25 in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of miR-25 in ESCC and to determine the molecular mechanisms underlying its function. The expression level of miR-25 was detected in primary ESCC tissues and cell lines by real-time quantitative PCR. We also assessed whether knockdown of miR-25 influences in vitro cell invasion and migration...
September 25, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29048643/novel-transduction-of-nutrient-stress-to-notch-pathway-by-rasgrp3-promotes-malignant-aggressiveness-in-human-esophageal-squamous-cell-carcinoma
#4
Ge Hu, Yuepeng Zhou, Yu Zhu, Ling Zhou, Rui Ling, Dan Wu, Lei Mi, Xuefeng Wang, Dongfang Dai, Chaoming Mao, Deyu Chen
In the process of enlarging of tumors, the dissolving tissue structures and remodeling endothelial cells for restoring gas exchange and nutritional support, further facilitate tumor cell invasion and metastasis. Activation of Ras plays a critical role in the development of esophageal squamous cell carcinoma (ESCC), but the underlying mechanisms remain poorly understood. We therefore investigated whether Ras guanyl-releasing protein 3 (RasGRP3), a Ras activator, could promote metastasis by inducing vascular regeneration and further epithelial-mesenchymal transition under nutrient stress (NS)...
September 25, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29047233/overexpression-of-mir-191-predicts-poor-prognosis-and-promotes-proliferation-and-invasion-in-esophageal-squamous-cell-carcinoma
#5
Xiaotian Gao, Zhanqiang Xie, Zhigang Wang, Keluo Cheng, Ke Liang, Zeqing Song
PURPOSE: Accumulating evidence has shown that dysregulation of microRNA-191 (miR-191) is closely associated with tumorigenesis and progression in a wide range of cancers. This study aimed to explore the potential role of miR-191 in esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: miR-191 expression was assessed in 93 ESCC tissue specimens by real-time polymerase chain reaction, and survival analysis was performed via Kaplan-Meier and Cox regression analyses...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29046713/hpv-infection-and-p53-and-p16-expression-in-esophageal-cancer-are-they-prognostic-factors
#6
Allini Mafra da Costa, José Humberto Tavares Guerreiro Fregnani, Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Estela Maria Silva, Cristovam Scapulatempo Neto, Denise Peixoto Guimarães, Luisa Lina Villa, Laura Sichero, Kari Juhani Syrjanen, Adhemar Longatto-Filho
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that may have impact on survival of ESCC. METHODS: We conducted a prospective cohort study...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29042418/socs1-gene-therapy-improves-radiosensitivity-and-enhances-irradiation-induced-dna-damage-in-esophageal-squamous-cell-carcinoma
#7
Takahito Sugase, Tsuyoshi Takahashi, Satoshi Serada, Minoru Fujimoto, Kosuke Hiramatsu, Tomoharu Ohkawara, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Tadamitsu Kishimoto, Masaki Mori, Yuichiro Doki, Tetsuji Naka
STAT3 has been implicated recently in radioresistance in cancer. In this study, we investigated the association between STAT3 and radioresistance in esophageal squamous cell carcinoma (ESCC). Strong expression of activated phospho-STAT3 (p-STAT3) was observed in 16/22 ESCC patients with preoperative chemoradiotherapy (CRT), compared to 9/24 patients with surgery alone, where the prognosis of those with CRT was poor. Expression of p-STAT3 and the anti-apoptotic proteins Mcl-1 and survivin was strongly induced in ESCC cells by irradiation...
October 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/29040480/cyfra-21-1-as-a-tumor-marker-for-squamous-cell-carcinoma-of-the-esophagus
#8
T Nakamura, H Ide, R Eguchi, K Hayashi, K Takasaki, S Watanabe
This study assessed the clinical value of CYFRA 21-1 in comparison with squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in patients with esophageal squamous cell carcinoma. In 112 primary cancer patients, the diagnostic sensitivity of CYFRA 21-1 (33.9%) was superior to SCC-Ag (28.6%), CEA (12.5%), and CA19-9 (6.3%). Levels of CYFRA 21-1 were closely correlated with TNM stage and were below the cutoff value in all 21 patients with stage I disease...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29039512/sporamin-suppresses-growth-of-human-esophageal-squamous-cell-carcinoma-cells-by-inhibition-of-nf%C3%A2-%C3%AE%C2%BAb-via-an-akt%C3%A2-independent-pathway
#9
Cui-Juan Qian, Yong-Xiao Qi, Xiao-Ying Chen, Ju-Ping Zeng, Jun Yao
The aim of the present study was to determine whether sporamin, a trypsin inhibitor, suppresses the growth of human esophageal squamous cell carcinoma (ESCC) cells in vitro. Sporamin treatment led to the suppression of viability and proliferation of human ESCC cell lines, EC9706 and EC109, as determined by MTT and [3H] thymidine incorporation assays, respectively. Flow cytometry and fluorescence microscopy demonstrated that sporamin significantly induced apoptosis in EC9706 and EC109 cells. Western blotting demonstrated that sporamin downregulated the expression of Bcl‑2 and Bcl‑2 like 1, and upregulated the expression of Bcl‑2‑associated X in EC9706 and EC109 cells...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29037837/the-correlation-between-xiap-gene-polymorphisms-and-esophageal-squamous-cell-carcinoma-susceptibility-and-prognosis-in-a-chinese-population
#10
Hai Peng, Li-Guo Wang, Xue-Zhi Wang, Ai-Jun Liu
OBJECTIVE: This study aims to explore the correlation between X-linked inhibitor of apoptosis protein (XIAP) gene polymorphisms (rs8371 and rs9856) with the susceptibility and prognosis of esophageal squamous cell carcinoma (ESCC), providing a potential treatment for ESCC. METHOD: A total of 170 ESCC patients (case group) and 191 healthy people (control group) were enrolled in our study. Genotyping was conducted on the basis of the ligase detection reaction (LDR)...
October 9, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29036607/endoscopic-and-histopathologic-reflux-associated-mucosal-damage-in-the-remnant-esophagus-following-transthoracic-esophagectomy-for-cancer-5-year-long-term-follow-up
#11
H F Fuchs, H M Schmidt, M Meissner, S Brinkmann, M Maus, M Bludau, W Schröder, A H Hölscher, J M Leers
Gastroesophageal reflux is a common problem following esophagectomy and reconstruction with gastric interposition. Despite a routine prescription of proton pump inhibitors, reflux-associated mucosal damage in the remnant esophagus is frequently observed. Purpose of this study is to evaluate mucosal damage in the esophageal remnant during long-term follow-up and to compare the prevalence of this damage between the subgroups of esophageal squamous cell and adenocarcinoma. All patients undergoing transthoracic Ivor-Lewis esophagectomy were prospectively entered in our IRB approved database...
September 21, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036528/prediction-of-pathologic-responders-to-neoadjuvant-chemoradiotherapy-by-diffusion-weighted-magnetic-resonance-imaging-in-locally-advanced-esophageal-squamous-cell-carcinoma-a-prospective-study
#12
Q-W Li, B Qiu, B Wang, D-L Wang, S-H Yin, H Yang, J-L Liu, J-H Fu, M-Z Liu, C-M Xie, H Liu
This study aims to investigate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in ESCC patients receiving neoadjuvant concurrent chemoradiotherapy (CCRT), and the efficacy of apparent diffusion coefficient (ADC) values in predicting pathologic response to neoadjuvant CCRT. Twenty-eight locally advanced ESCC patients treated with neoadjuvant CCRT followed by radical resection were prospectively enrolled. DW-MRI was recommended to be performed within 2 weeks before and 4-6 weeks after neoadjuvant CCRT...
September 27, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29033778/a-case-of-basaloid-squamous-cell-carcinoma-of-polypoid-type-in-the-esophagus
#13
Ki Hun Lee, Sang Jin Lee, Hak Soo Kim, Sung Eun Kim, Soo Yong Choi, Hyun Ju Lee, Suk Hun Ha, Kwang Hoon Oh, Dae-Woon Eom
Basaloid squamous cell carcinoma of the esophagus is very rare. Further, polypoid type of esophageal cancer is also rare. We have recently treated a case of basaloid squamous cell carcinoma which presented as a 1.3-cm esophageal polyp. A 48-year-old woman was referred to our hospital because of a polypoid mass at 36 cm distance from the upper incisor on endoscopic examination, and the result of the biopsy was basaloid squamous cell carcinoma. The patient underwent Ivor Lewis operation with lymph node dissection...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033590/sitting-time-and-occupational-and-recreational-physical-activity-in-relation-to-the-risk-of-esophageal-squamous-cell-carcinoma
#14
Pengxiang Chen, Qingxu Song, Jie Han, Huapu Xu, Tong Chen, Jiaqi Xu, Yufeng Cheng
BACKGROUNDS: Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT) on ESCC risk. METHODS: Five hundred fifty-seven ESCC patients and 543 healthy controls matched by sex and age were recruited for this study. Conditional logistic regression was performed to obtain odds ratios (ORs) and 95% confidence intervals (CIs)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29033183/the-overexpression-and-predictive-significance-of-mmp-12-in-esophageal-squamous-cell-carcinoma
#15
Fei Han, Suxia Zhang, Long Zhang, Qiongyu Hao
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor invasion and metastasis. MMP-12, as metalloelastase, its function in tumor progression remains contradictory. This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells...
September 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29033014/clinicopathologic-features-of-submucosal-esophageal-squamous-cell-carcinoma
#16
Manabu Emi, Jun Hihara, Yoichi Hamai, Takaoki Furukawa, Yuta Ibuki, Morihito Okada
BACKGROUND: The prognoses of submucosal esophageal squamous cell carcinoma patients vary. Patients with favorable prognoses may receive less invasive or nonsurgical interventions, whereas patients with poor prognoses or advanced esophageal cancer may require aggressive treatments. We sought to identify prognostic factors for patients with submucosal esophageal squamous cell carcinoma, focusing on lymph node metastasis and recurrence. METHODS: We included 137 submucosal esophageal squamous cell carcinoma patients who had undergone transthoracic esophagectomy with systematic extended lymph node dissection...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29030780/endoscopic-treatment-versus-esophagectomy-for-early-stage-esophageal-cancer-a-population-based-study-using-propensity-score-matching
#17
Yuan Zeng, Wenhua Liang, Jun Liu, Jianxing He
BACKGROUND: Endoscopic treatment (ET) is an alternative for selected patients with early-stage esophageal cancer. The primary aim of this study was to compare overall survival (OS) and esophageal cancer-specific survival (ECSS) of such patients after ET or esophagectomy. METHODS: Propensity score matching (PSM) and Cox regression analysis were used to compare OS and ECSS of 2661 patients with ET or esophagectomy for early-stage (Tis-T1N0M0) disease. Patient information was retrieved from the Surveillance, Epidemiology, and End Results database...
October 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29030675/evaluation-of-prognostic-factors-for-esophageal-squamous-cell-carcinoma-treated-with-neoadjuvant-chemoradiotherapy-followed-by-surgery
#18
Yoichi Hamai, Jun Hihara, Manabu Emi, Takaoki Furukawa, Yuji Murakami, Ikuno Nishibuchi, Yuta Ibuki, Ichiko Yamakita, Tomoaki Kurokawa, Yasushi Nagata, Morihito Okada
BACKGROUND: Intensive trimodality therapy is needed for locally advanced esophageal squamous cell carcinoma (ESCC). However, some patients develop recurrence and die of cancer even after trimodality therapy. METHODS: We evaluated prognostic factors based on data from 125 patients with ESCC who underwent neoadjuvant chemoradiotherapy (NCRT) comprising concurrent chemotherapy and 40 Gy of radiation, followed by curative-intent esophagectomy. RESULTS: Thirty-four (27...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29029520/prognostic-role-of-intratumoral-il-17a-expression-by-immunohistochemistry-in-solid-tumors-a-meta-analysis
#19
Shimin Wang, Zhi'an Li, Guoming Hu
IL-17A is an important proinflammatory cytokine which is frequently elevated in tumor microenvironment. However, the role of intratumoral IL-17A in solid tumors remains controversial. Herein, we conducted a meta-analysis to assess the prognostic impact of intratumoral IL-17A in patients with solid tumor. PubMed and EBSCO were searched to identify the studies evaluating the associations between intratumoral IL-17A measured by immunohistochemistry (IHC) and overall survival (OS) and disease-free survival (DFS) in solid tumors...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029485/fzd7-is-a-novel-prognostic-marker-and-promotes-tumor-metastasis-via-wnt-and-emt-signaling-pathways-in-esophageal-squamous-cell-carcinoma
#20
Ting-Ting Cao, Di Xiang, Bei-Lei Liu, Tu-Xiong Huang, Bin-Bin Tan, Chui-Mian Zeng, Zhong-Yuan Wang, Xiao-Yan Ming, Li-Yi Zhang, Guangyi Jin, Feng Li, Jian-Lin Wu, Xin-Yuan Guan, Desheng Lu, Li Fu
Frizzled (FZD) proteins are receptors for secreted WNT proteins and play a critical role in the malignant progression of various cancers. However, the role of human FZD family members in esophageal squamous cell carcinoma (ESCC) was rarely investigated. In this study, we found that the FZD7 gene was the most commonly up-regulated FZD member in ESCC cell lines compared with other FZDs. TMA studies further validated that FZD7 protein was up-regulated in 165 of 252 (65.5%) informative ESCC patients and significantly correlated with poor overall survival (P=0...
September 12, 2017: Oncotarget
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