Jianfeng Yao, Rongfu Huang, Ming Li, Yi Jiang, Peiya Wu, Youzhu Li, Weilin Peng, Chengzhou Hua, Yanfang Huang, Huifang You, Yuanyuan Chen, Dianliang Lin, Xiaoyu Yang
The ovarian reserve determines the success of in vitro fertilization (IVF) and embryo transfer treatment. It predicts the ovarian response in controlled ovarian hyperstimulation cycles. Apoptosis in granulosa cells surrounding oocytes is important for ovarian function and has been closely associated with follicular atresia. PTEN (encoding phosphatase and tensin homolog) is a well-known tumor suppressor gene that functions as a mediator of apoptosis and is crucial for mammal reproduction. In the present study, we analyzed the expression level of PTEN in human granulosa cells and aimed to investigate its association with the ovarian response and clinical outcomes in IVF...
January 13, 2021: Reproductive Sciences