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Poor response to COH

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https://www.readbyqxmd.com/read/27793383/steroid-hormone-pretreatments-in-assisted-reproductive-technology
#1
REVIEW
Jean Nassar, Teddy Tadros, Elodie Adda-Herzog, Jean Marc Ayoubi, Renato Fanchin
Adequate availability and FSH sensitivity of ovarian antral follicles and coordination of their growth during controlled ovarian hyperstimulation (COH) rank among factors that may determine outcome, particularly in patients presenting ovarian function defects and so-called "poor responders." Growing evidence indicates that both factors are positively influenced by steroid hormone pretreatments. First, data from studies conducted in both animals and in women exposed to virilizing androgen doses indicate that androgen pretreatments may increase follicle responsiveness to FSH and/or the number of growing follicles in the ovary, thereby constituting an interesting perspective in the management of "poor responders...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27301324/biosimilar-fsh-preparations-are-they-identical-twins-or-just-siblings
#2
EDITORIAL
Raoul Orvieto, David B Seifer
As patents expire on innovator products, there is increasing interest in developing biosimilar products globally. Biosimilars are not exact copies and are not considered generic versions of the reference product. They may differ in strength, purity and contain different composition of isoforms and/or various glycosylation profiles, with the consequent alterations in clinical efficacy or safety. Recently 2 new recombinant FSH preparations were introduced to clinical practice following randomized controlled, phase 3 clinical trials...
2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27126581/gonadotrophin-releasing-hormone-antagonists-for-assisted-reproductive-technology
#3
REVIEW
Hesham G Al-Inany, Mohamed A Youssef, Reuben Olugbenga Ayeleke, Julie Brown, Wai Sun Lam, Frank J Broekmans
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) antagonists can be used to prevent a luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH) without the hypo-oestrogenic side-effects, flare-up, or long down-regulation period associated with agonists. The antagonists directly and rapidly inhibit gonadotrophin release within several hours through competitive binding to pituitary GnRH receptors. This property allows their use at any time during the follicular phase...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26963897/does-dehydroepiandrosterone-improve-pregnancy-rate-in-women-undergoing-ivf-icsi-with-expected-poor-ovarian-response-according-to-the-bologna-criteria-a-randomized-controlled-trial
#4
Mohamed M M Kotb, AbdelGany M A Hassan, Ahmed M A AwadAllah
OBJECTIVE: To provide the best available evidence on the role of dehydroepiandrosterone (DHEA) treatment in improving the outcome of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in women with poor ovarian response (POR). STUDY DESIGN: A randomized controlled trial conducted in Cairo University hospitals and Dar Al-Teb subfertility and assisted conception centre, Giza, Egypt. 140 women undergoing IVF/ICSI with POR according to the Bologna criteria were randomly divided into 2 equal groups...
May 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26677665/-smoothing-gan-reinforcing-shen-method-adjuvantly-treated-poor-response-of-diminished-ovari-an-reserve-patients-in-in-vitro-fertilization-and-embryo-transfer-a-clinical-study
#5
RANDOMIZED CONTROLLED TRIAL
Zheng Zhang, Xue-hong Zhang, Tian-you He
OBJECTIVE: To study clinical efficacy of smoothing Gan reinforcing Shen (SGRS) method in treating poor response of diminished ovarian reserve (DOR) patients in in vitro fertilization and embryo, transfer (IVF-ET). METHODS: Totally 84 DOR patients undergoing IVF-ET were assigned to the experimental group (SGRS Chinese herbs as adjuvant therapy) and the control group according to random digit table, 42 in each group. Patients in the control group received controlled ovarian hyperstimulation (COH) and IVF-ET...
October 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26637351/transferrin-receptor-1-facilitates-poliovirus-permeation-of-mouse-brain-capillary-endothelial-cells
#6
Taketoshi Mizutani, Aya Ishizaka, Coh-Ichi Nihei
As a possible route for invasion of the CNS, circulating poliovirus (PV) in the blood is believed to traverse the blood-brain barrier (BBB), resulting in paralytic poliomyelitis. However, the underlying mechanism is poorly understood. In this study, we demonstrated that mouse transferrin receptor 1 (mTfR1) is responsible for PV attachment to the cell surface, allowing invasion into the CNS via the BBB. PV interacts with the apical domain of mTfR1 on mouse brain capillary endothelial cells (MBEC4) in a dose-dependent manner via its capsid protein (VP1)...
February 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26536862/a-simplified-universal-approach-to-coh-protocol-for-ivf-ultrashort-flare-gnrh-agonist-gnrh-antagonist-protocol-with-tailored-mode-and-timing-of-final-follicular-maturation
#7
Raoul Orvieto
Recently, several new promising modifications have been introduced to clinical practice that may simplify and optimize IVF outcome. In the present opinion paper we present a simplified approach to controlled ovarian hyperstimulation protocol (COH), which combines the benefits of the ultrashort flare GnRH agonist/GnRH antagonist protocol and the personalized tailored mode and timing of ovulation triggering, aiming to improve IVF outcome while eliminating of severe OHSS.In patients at risk to develop severe ovarian hyperstimulation syndrome (OHSS), GnRH agonist (GnRHa) trigger if offered for final follicular maturation...
November 4, 2015: Journal of Ovarian Research
https://www.readbyqxmd.com/read/26357853/optimal-cutoff-value-of-basal-anti-mullerian-hormone-in-iranian-infertile-women-for-prediction-of-ovarian-hyper-stimulation-syndrome-and-poor-response-to-stimulation
#8
Malek Mansour Aghssa, Azam Manshadi Tarafdari, Ensieh Shahrokh Tehraninejad, Mohammad Ezzati, Maryam Bagheri, Zahra Panahi, Saeed Mahdavi, Mehrshad Abbasi
AIM: We intended to establish the threshold of Anti-Mullerian Hormone (AMH) for detection of Ovarian Hyper-Stimulation Syndrome (OHSS) and poor response to treatment in Iranian infertile women. METHODS: Pre-stimulation menstrual cycle day-3 hormonal indices including basal AMH values were measured in 105 infertile women aged 32.5 ± 4.3 years. Patients underwent long GnRH agonist Controlled Ovarian Hyperstimulation (COH) in a referral infertility center (Tehran, Iran)...
2015: Reproductive Health
https://www.readbyqxmd.com/read/26313385/poor-responders-in-ivf-is-there-any-evidence-based-treatment-for-them
#9
REVIEW
Iwona Szymusik, Piotr Marianowski, Aleksandra Zygula, Miroslaw Wielgos
Despite the vast experience in controlled ovarian hyperstimulation, there are still women who respond poorly to gonadotropins, which results in few oocytes at retrieval, reduced number of embryos for transfer and consequently unsatisfactory pregnancy rates. Although such patients are quite common in IVF practice, the exact prevalence of so-called "poor responders" is difficult to estimate due to the variety of applied definitions. The urgent need for an internationally accepted definition of poor ovarian response (POR) was addressed by an ESHRE Workshop held in Bologna in 2010, where the consensus was reached and criteria were finally established...
2015: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/26207230/comparison-of-different-stimulation-protocols-used-in-in-vitro-fertilization-a-review
#10
REVIEW
Deekshya Shrestha, Xiaolin La, Huai L Feng
Infertility is one of the major medical problems in the western world caused by genetic or epigenetic factors, or both, which has led to continuous research and advancements in the field of assisted reproductive technology (ART). Many stimulation protocols are available for controlled ovarian hyperstimulation (COH) in in vitro fertilization (IVF). This review compares the agonist long protocol, antagonist protocol and minimal stimulation protocol. Gonadotropin-releasing hormone (GnRH) antagonist and minimal stimulation protocol has shorter duration of treatment and less gonadotropin use...
June 2015: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26067283/myo-inositol-therapy-for-poor-responders-during-ivf-a-prospective-controlled-observational-trial
#11
Francesca Caprio, Maria Diletta D'Eufemia, Carlo Trotta, Maria Rosaria Campitiello, Raffaele Ianniello, Daniela Mele, Nicola Colacurci
BACKGROUND: The overall incidence of poor ovarian response in IVF cycles has been reported to be between 9 and 24%. The management of these patients remains a significant challenge in assisted reproduction. The aim of the present study was to evaluate the effect of myo-inositol (MI) on ovarian function in poor responders undergoing ICSI. METHODS: The study is a prospective controlled observational trial, that involved 72 poor responders included in an ICSI program and divided into two groups; group A: 38 patients who have been assuming MI (4 g) + folic acid (FA) (400 μg) for the previous 3 months before the enrollment day; group B: 38 patients assuming FA (400 μg) alone for the same period...
2015: Journal of Ovarian Research
https://www.readbyqxmd.com/read/25884482/menstrual-cycle-length-a-surrogate-measure-of-reproductive-health-capable-of-improving-the-accuracy-of-biochemical-sonographical-ovarian-reserve-test-in-estimating-the-reproductive-chances-of-women-referred-to-art
#12
Salvatore Gizzo, Alessandra Andrisani, Marco Noventa, Michela Quaranta, Federica Esposito, Decio Armanini, Michele Gangemi, Giovanni B Nardelli, Pietro Litta, Donato D'Antona, Guido Ambrosini
BACKGROUND: Aim of the study was to investigate whether menstrual cycle length may be considered as a surrogate measure of reproductive health, improving the accuracy of biochemical/sonographical ovarian reserve test in estimating the reproductive chances of women referred to ART. METHODS: A retrospective-observational-study in Padua' public tertiary level Centre was conducted. A total of 455 normo-ovulatory infertile women scheduled for their first fresh non-donor IVF/ICSI treatment...
2015: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/25753867/the-comparison-of-microdose-flare-up-and-multiple-dose-antagonist-protocols-based-on-hcg-day-estradiol-e2-progesterone-p-and-p-e2-ratio-among-poor-responder-patients-in-icsi-et-cycles
#13
COMPARATIVE STUDY
M N Cicek, I Kahyaoglu, S Kahyaoglu
OBJECTIVE: Elevated progesterone levels surpassing exact treshold values impede endometrial receptivity and decrease clinical pregnancy rates in different responder patients during assisted reproductive techniques. A progesterone (P): estradiol (E2) ratio of > 1 on the day of hCG administration has also been suggested to be a manifestation of low ovarian reserve. The clinical significance of P/E2 ratio on the day of hCG administration was investigated among poor responder patients...
February 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25740883/surgical-diminished-ovarian-reserve-after-endometrioma-cystectomy-versus-idiopathic-dor-comparison-of-in-vitro-fertilization-outcome
#14
COMPARATIVE STUDY
Audrey Roustan, Jeanne Perrin, Mathias Debals-Gonthier, Odile Paulmyer-Lacroix, Aubert Agostini, Blandine Courbiere
STUDY QUESTION: Does the live birth rate after IVF depend on the etiology of diminished ovarian reserve (DOR)? SUMMARY ANSWER: IVF outcome and live birth rate are significantly impaired in women with DOR caused by a previous cystectomy for endometrioma compared with women with idiopathic DOR. WHAT IS KNOWN ALREADY: The safety of the surgical treatment of endometriomas is being discussed in terms of damage to ovarian reserve. Several studies have reported a poor response to controlled ovarian stimulation and a significantly impaired IVF outcome in women with DOR consecutive to an endometrioma cystectomy compared with women with tubal factor infertility...
April 2015: Human Reproduction
https://www.readbyqxmd.com/read/25740882/recombinant-follicle-stimulating-hormone-and-recombinant-luteinizing-hormone-versus-recombinant-follicle-stimulating-hormone-alone-during-gnrh-antagonist-ovarian-stimulation-in-patients-aged-%C3%A2-35-years-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
T N L Vuong, H T Phung, M T Ho
STUDY QUESTION: Does luteinizing hormone (LH) supplementation improve live birth rate after in vitro fertilization (IVF) in patients aged ≥35 years receiving a gonadotrophin-releasing hormone (GnRH) antagonist protocol? SUMMARY ANSWER: There was no difference in live birth rate with use of LH during IVF in patients aged ≥35 years undergoing IVF treatment using a GnRH antagonist protocol. WHAT IS KNOWN ALREADY: Use of GnRH analogues as part of a controlled ovarian hyperstimulation protocol during IVF treatment cycles decreases the amount of LH available to developing follicles...
May 2015: Human Reproduction
https://www.readbyqxmd.com/read/25671507/can-serum-estradiol-levels-on-the-fourth-day-of-ivf-icsi-cycle-predict-outcome-in-poor-responder-women
#16
Serkan Kahyaoglu, Omer H Yumusak, A Seval Ozgu-Erdinc, Saynur Yilmaz, Inci Kahyaoglu, Yaprak Engin-Ustun, Nafiye Yilmaz
We aimed to investigate the value of fourth day serum estradiol levels in predicting cycle outcome in poor responders. The medical records of 426 patients with low oocyte yield following controlled ovarian hyperstimulation (COH) treatment for a procedure in our institution's center for ART between 2008 and 2013 were evaluated. Eighty-eight patients exhibiting poor ovarian response (POR) were included in the study. The clinical outcomes of IVF/ICSI were compared based on the basal hormone profile, clinical, and laboratory parameters...
2015: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/25526787/evaluating-influence-of-the-genotypes-in-the-follicle-stimulating-hormone-receptor-fshr-ser680asn-rs6166-polymorphism-on-poor-and-hyper-responders-to-ovarian-stimulation-a-meta-analysis
#17
Noel Pabalan, Camila Martins Trevisan, Carla Peluso, Hamdi Jarjanazi, Denise Maria Christofolini, Caio Parente Barbosa, Bianca Bianco
BACKGROUND/AIMS: Reported associations of controlled ovarian hyperstimulation response (COH) with genotypes of the Ser680Asn (N680S) polymorphism in the follicle stimulating hormone receptor (FSHR) gene have conflicting results. METHODS: PubMed and Embase databases were searched for studies that investigated the N680S polymorphism in the FSHR gene in COH. Parameters used to examine ovarian response were poor and hyper-responses to COH. Using the meta-analytic approach, we estimated ovarian response risk (odds ratio [OR] with 95% confidence intervals) according to genotype...
2014: Journal of Ovarian Research
https://www.readbyqxmd.com/read/25469124/the-luteinizing-hormone-beta-subunit-exon-3-gly102ser-gene-mutation-and-ovarian-responses-to-controlled-ovarian-hyperstimulation
#18
Robab Davar, Nasim Tabibnejad, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha
BACKGROUND: Despite extensive progress in IVF techniques, one of the most difficult problems is the variability in the response to controlled ovarian hyperstimulation (COH). Recent studies show the effects of individual genetic variability on COH outcome. OBJECTIVE: To evaluate the correlation between LHβ G1502A polymorphisms in exon 3 of the LH gene and ovarian response to COH. MATERIALS AND METHODS: A total of 220 women treated with a long protocol for ovarian stimulation were studied...
October 2014: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25373014/a-pharmacogenetic-driven-approach-for-controlled-ovarian-hyperstimulation-by-fsh-treatment
#19
COMPARATIVE STUDY
R Colognato, R Aiello, F Dulcetti, A M Ruggeri, S De Toffol, L Marcato, A M Irollo, C Criscuolo, M F Gangale, F Maggi, G Simoni
AIM: The aim of this study was to develop a pharmacogenetic- (PGx) driven approach for a controlled ovarian hyperstimulation (COH) treatment protocol used for in vitro fertilization procedures. The enrolled patients were genotyped for a single nucleotide polymorphism (SNP) N680S, within the FSHR. METHODS: Seventy-eight women, who had previously received at least two COH cycles without positive fertilization with FSH and AMH values <10 mUI/mL and >0.3 ng/mL respectively were enrolled...
December 2014: Minerva Ginecologica
https://www.readbyqxmd.com/read/25317041/obesity-is-not-associated-with-the-poor-pregnancy-outcome-following-intracytoplasmic-sperm-injection-in-women-with-polycystic-ovary-syndrome
#20
Funda Akpınar, Berfu Demir, Serdar Dilbaz, Iskender Kaplanoğlu, Berna Dilbaz
OBJECTIVE: To determine if body mass index has an effect on the outcome of in vitro fertilization in patients with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation. MATERIAL AND METHODS: The study included 337 cycles. Patients were stratified into the following 3 groups: normal weight, overweight, and obese. The primary outcome measures were response to ovarian hyperstimulation, the fertilization rate, the implantation rate, and the clinical and ongoing pregnancy rates...
2014: Journal of the Turkish German Gynecological Association
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