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Male factor infertility

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https://www.readbyqxmd.com/read/29673675/the-association-between-in-vitro-fertilization-outcome-and-the-inflammatory-markers-of-complete-blood-count-among-nonobese-unexplained-infertile-couples
#1
Esra Nur Tola
OBJECTIVE(S): The purpose of our study was to evaluate whether the inflammatory parameters of complete blood count (CBC), including white blood cell (WBC), neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and mean platelet volume (MPV), had potential roles in the etiopathogenesis of unexplained infertility (UI) among nonobese women. We also aimed to investigate whether there could be an association between these markers and in vitro fertilization (IVF) success among nonobese women with UI...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673662/the-influence-of-ovarian-hyperstimulation-drugs-on-morphometry-and-morphology-of-human-oocytes-in-icsi-program
#2
Fatemeh Taheri, Arezoo Alemzadeh Mehrizi, Mohammad Ali Khalili, Iman Halvaei
OBJECTIVE: To compare the influences of controlled ovarian hyperstimulation (COH) drugs using recombinant follicular stimulating hormone (rFSH) versus human menopausal gonadotropins (hMG) on morphometry and morphology of MII oocytes in ICSI cycles. MATERIALS AND METHODS: In this prospective study, 363 MII oocytes from 50 ICSI cycles with male factor infertility were evaluated. The patients were divided into two groups according to the protocols of COH: I- rFSH and II- hMG...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673127/cstf2t-regulates-expression-of-histones-and-histone-like-proteins-in-male-germ-cells
#3
P N Grozdanov, J Li, P Yu, W Yan, C C MacDonald
Formation of the 3' ends of mature mRNAs requires recognition of the correct site within the last exon, cleavage of the nascent pre-mRNA, and, for most mRNAs, addition of a poly(A) tail. Several factors are involved in recognition of the correct 3'-end site. The cleavage stimulation factor (CstF) has three subunits, CstF-50 (gene symbol Cstf1), CstF-64 (Cstf2), and CstF-77 (Cstf3). Of these, CstF-64 is the RNA-binding subunit that interacts with the pre-mRNA downstream of the cleavage site. In male germ cells where CstF-64 is not expressed, a paralog, τCstF-64 (gene symbol Cstf2t) assumes its functions...
April 19, 2018: Andrology
https://www.readbyqxmd.com/read/29673000/effect-of-insemination-timing-on-pregnancy-outcome-in-association-with-female-age-sperm-motility-sperm-morphology-and-sperm-concentration-in-intrauterine-insemination
#4
Jisun Lee, Suna Hwang, Jaehun Lee, Junghyun Yoo, Dongmin Jang, Kyungjoo Hwang, Miran Kim
AIM: We investigated the effect of insemination timing on pregnancy outcomes in intrauterine insemination (IUI) cycles. METHODS: This is a retrospective study of 411 IUI cycles performed with a diagnosis of unexplained infertility and male factor infertility. The cycles were divided according to the interval between insemination and ovulation: ≤36 h, 36-37 h, 37-38 h and >38 h. The overall pregnancy rate, chemical pregnancy rate and clinical pregnancy rate were compared...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29671528/testicular-cancer-diagnosis-and-treatment
#5
Drew C Baird, Garrett J Meyers, Jocelyn S Hu
Testicular cancer is the most common solid tumor among males 15 to 34 years of age, with an estimated 8,850 new cases and 410 deaths during 2017 in the United States. With effective treatment, the overall five-year survival rate is 97%. Risk factors for testicular cancer include undescended testis (cryptorchidism), personal or family history of testicular cancer, age, ethnicity, and infertility. The U.S. Preventive Services Task Force recommends against routine screening in asymptomatic men. Men with symptoms should receive a complete history and physical examination...
February 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29670782/endometriosis-in-a-man-as-a-rare-source-of-abdominal-pain-a-case-report-and-review-of-the-literature
#6
Christina Rei, Thomas Williams, Michael Feloney
Endometriosis occurs when a tissue resembling endometrial glands and stroma grows in ectopic sites, commonly causing infertility and pain. This condition is most often seen in women of reproductive age, involving pelvic sites such as the ovaries, broad ligaments, uterosacral ligaments, and posterior cul-de-sac. Very rarely, endometriosis has also been found in the lower genitourinary tract of men. A 40-year-old man presented to his primary care physician with abdominal pain. Further imaging discovered a midline mass...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29670338/preference-for-anonymity-in-sperm-donation-for-artificial-insemination-an-experience-from-low-resource-settings-in-nigeria
#7
Euzebus Chinonye Ezugwu, George U Eleje, Chukwuemeka A Iyoke, Sunday G Mba, Henry C Nnaji, Chukwunonso I Enechukwu, Peter O Nkwo
Objective: Anonymous sperm donation is a common practice in Nigeria with its associated legal and ethical challenges. This study aimed to investigate infertile couples' opinions about issues of sperm donor anonymity and to determine factors that might influence their preferences. Methods: A cross-sectional, multicentered, questionnaire-based study was conducted among infertile couples attending infertility clinics in three tertiary hospitals in the south-eastern region of Nigeria over a period of 6 months...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29667546/seminal-supar-levels-as-marker-of-abacterial-male-accessory-gland-inflammation-in-hypogonadism
#8
Domenico Milardi, Giuseppe Grande, Chiara Autilio, Francesca Mancini, Laura De Marinis, Riccardo Marana, Cecilia Zuppi, Andrea Urbani, Alfredo Pontecorvi, Silvia Baroni
Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI)...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29664790/should-we-consider-telomere-length-and-telomerase-activity-in-male-factor-infertility
#9
Carlos Balmori, Elisa Varela
PURPOSE OF REVIEW: The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. RECENT FINDINGS: Cells in germ series, including spermatozoids, have longer telomeres (10-20 kb), and do not seem to undergo the shortening that takes place in somatic cells with age as they present telomerase activity...
April 16, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29663341/perceptions-of-risk-of-infertility-among-male-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#10
Jordan Gilleland Marchak, Kristy D Seidel, Ann C Mertens, Chad W M Ritenour, Karen Wasilewski-Masker, Wendy M Leisenring, Charles A Sklar, Jennifer S Ford, Kevin R Krull, Marilyn Stovall, Leslie L Robison, Gregory T Armstrong, Lillian R Meacham
BACKGROUND: The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer. METHODS: A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility compared with men never diagnosed with cancer. Survivors were a median age of 37...
April 17, 2018: Cancer
https://www.readbyqxmd.com/read/29662826/an-infertile-patient-with-y-chromosome-b1-b3-deletion-presenting-with-congenital-bilateral-absence-of-the-vas-deferens-with-normal-spermatogenesis
#11
Shinnosuke Kuroda, Kimitsugu Usui, Kohei Mori, Kengo Yasuda, Takuo Asai, Hiroyuki Sanjo, Hiroyuki Yakanaka, Teppei Takeshima, Takashi Kawahara, Haruka Hamanoue, Yoshitake Kato, Yasuhide Miyoshi, Hiroji Uemura, Akira Iwasaki, Yasushi Yumura
We report the case of a 46-year-old Chinese male patient who visited our clinic complaining of infertility. Semen analysis revealed azoospermia, and azoospermia factor c region partial deletion (b1/b3) was detected using Y chromosome microdeletion analysis. Testicular sperm extraction was performed after genetic counseling. The bilateral ductus deferens and a portion of the epididymis were absent, whereas the remaining epididymis was expanded. Motile intratesticular spermatozoa were successfully extracted from the seminiferous tubule...
March 2018: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29662824/knowledge-regarding-factors-that-influence-fertility-in-thai-reproductive-age-population-living-in-urban-area-a-cross-sectional-study
#12
Sarapan Na Nakhon, Pawan Limvorapitux, Patsama Vichinsartvichai
Objective: To survey knowledge about the factors that influence fertility in a reproductive-age population living in an urban area. Methods: A cross-sectional study was conducted using a questionnaire-based survey among both males and females aged 18-45 years living in the Bangkok metropolitan area. Results: The mean age of the participants was 26.8±7.2 years (male, 41.9%; female, 58.1%). Of the participants, 53.1% had an undergraduate degree and 57...
March 2018: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29661259/low-fertility-fecundity-and-numbers-of-mated-female-offspring-explain-the-lower-reproductive-success-of-the-parasitic-mite-varroa-destructor-in-african-honeybees
#13
Beatrice T Nganso, Ayuka T Fombong, Abdullahi A Yusuf, Christian W W Pirk, Charles Stuhl, Baldwyn Torto
Although Varroa destructor is the most serious ecto-parasite to the honeybee, Apis mellifera L., some honeybee populations such as Apis mellifera scutellata in Kenya can survive mite infestations without treatment. Previously, we reported that grooming behaviour could be a potential tolerant mechanism expressed by this honeybee subspecies towards mite infestation. However, both hygienic and grooming behaviours could not explain the lower mite-infestation levels recorded in these colonies. Here, we investigated the involvement of other potential resistant mechanisms including suppression of mite reproduction in worker brood cells of A...
April 17, 2018: Parasitology
https://www.readbyqxmd.com/read/29657603/impact-of-physical-activity-and-exercise-on-male-reproductive-potential-a-new-assessment-questionnaire
#14
D Vaamonde, J M Garcia-Manso, A C Hackney
Male athletes in general are subjected to the same causes of infertility as the general population, but sports practice itself may be possibly an additional infertility factor or, at least an aggravating factor for a previously existing fertility condition; on the contrary, being physically active has been hypothesized to favor hormonal and seminological processes and could be beneficial for fertility. In this relationship, the different inherent parameters of physical activity-exercise (training volume, intensity, objective, organization and frequency) are of paramount importance...
June 2017: Revista andaluza de medicina del deporte
https://www.readbyqxmd.com/read/29656391/proteomic-analysis-of-sperm-proteins-in-infertile-men-with-high-levels-of-reactive-oxygen-species
#15
A Ayaz, A Agarwal, R Sharma, N Kothandaraman, Z Cakar, S Sikka
Oxidative stress is a significant risk factor for male infertility. A pro-oxidant testicular environment may alter the expression profile of functional sperm proteins and result in poor sperm quality. Patients and donors were divided into ROS (-) and ROS (+) groups. Using computational studies, and data mining of available literature on spermatozoa, oxidative stress and proteomics, we identified three core regulatory proteins angiotensin-converting enzyme (ACE), heat-shock protein (Hsp70) family A member 2 (HSPA2) and ribosomal protein subunit 27A (RPS27A) and seven interlink proteins NOS2, SUMO2, UBL4A, FBXO25, MAP3K3, APP and UBC...
April 15, 2018: Andrologia
https://www.readbyqxmd.com/read/29651938/semen-proteomics-reveals-the-impact-of-enterococcus-faecalis-on-male-fertility
#16
Giuseppe Grande, Federica Vincenzoni, Francesca Mancini, Silvia Baroni, Giovanni Luca, Riccardo Calafiore, Riccardo Marana, Massimo Castagnola, Alfredo Pontecorvi, Domenico Milardi
Infectious etiologies contribute to 15% of male factor infertility. Enterococcus faecalis is commonly identified in semen colture of infertile men and it is associated with significantly poorer semen quality. Aim of this study was to identify new seminal biomarkers for the male tract infection by E. faecalis, using proteomic profiling, in order to understand the effect of E. faecalis on the physiopathology of male reproduction. We included in the study ten patients seeking medical care for primary infertility with prostate-vescicular-epidydimitis and with microbiological analysis on semen and/or prostatic secretions positive for Enterococcus faecalis...
April 12, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29649254/uxt-is-required-for-spermatogenesis-in-mice
#17
Eric D Schafler, Phillip A Thomas, Susan Ha, Yu Wang, Keria Bermudez-Hernandez, Zuojian Tang, David Fenyö, Margarita Vigodner, Susan K Logan
Male mammals must simultaneously produce prodigious numbers of sperm and maintain an adequate reserve of stem cells to ensure continuous production of gametes throughout life. Failures in the mechanisms responsible for balancing germ cell differentiation and spermatogonial stem cell (SSC) self-renewal can result in infertility. We discovered a novel requirement for Ubiquitous Expressed Transcript (UXT) in spermatogenesis by developing the first knockout mouse model for this gene. Constitutive deletion of Uxt is embryonic lethal, while conditional knockout in the male germline results in a Sertoli cell-only phenotype during the first wave of spermatogenesis that does not recover in the adult...
2018: PloS One
https://www.readbyqxmd.com/read/29648649/infectious-inflammatory-and-autoimmune-male-factor-infertility-how-do-rodent-models-inform-clinical-practice
#18
Monika Fijak, Adrian Pilatz, Mark P Hedger, Nour Nicolas, Sudhanshu Bhushan, Vera Michel, Kenneth S K Tung, Hans-Christian Schuppe, Andreas Meinhardt
BACKGROUND: Infection and inflammation of the reproductive tract are significant causes of male factor infertility. Ascending infections caused by sexually transmitted bacteria or urinary tract pathogens represent the most frequent aetiology of epididymo-orchitis, but viral, haematogenous dissemination is also a contributory factor. Limitations in adequate diagnosis and therapy reflect an obvious need for further understanding of human epididymal and testicular immunopathologies and their contribution to infertility...
April 10, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29629734/changes-of-sperm-parameters-along-time-among-groups-of-different-qualities
#19
Shimi Barda, Tomer Bar-Noy, Amnon Botchan, Ofer Lehavi, Haim Yavetz, Ron Hauser
BACKGROUND: Male infertility is solely responsible for approximately 20% of all infertility in couples. Various factors have been proposed as having a negative effect on sperm quality; however, the reasons for the global decline in sperm parameters during the last few decades are still controversial. OBJECTIVES: To investigate the fluctuations of semen parameters (sperm concentration, motility, and morphology) in three sperm quality groups and to examine the trends of those parameters in the same men over time...
April 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29627965/association-of-t-a-polymorphism-in-mir-1302-binding-site-in-cga-gene-with-male-infertility-in-isfahan-population
#20
Mina Jamalvandi, Majid Motovali-Bashi, Farzane Amirmahani, Parisa Darvishi, Kiarash Jamshidi
Infertility occurs in 10-15% of couples worldwide and close to half of it is caused by male factors. One of the genes that can affect male infertility is CGA. Polymorphisms in CGA gene may affect gene expression, therefore affecting male infertility by disrupting the regulation of this gene. One of the polymorphisms is the substitution of T with A in the miR-1302 binding site in the 3' untranslated region of the CGA gene. In this study, we explored this polymorphism in Isfahan population. In this case-control study, by the use of Tetra primer-ARMS-PCR technique, rs6631 has been investigated in 224 infertile men and 196 controls...
April 7, 2018: Molecular Biology Reports
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