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Male factor infertility

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https://www.readbyqxmd.com/read/29046342/the-pioneering-of-intracytoplasmic-sperm-injection-historical-perspectives
#1
Zev Rosenwaks, Nigel Pereira
Intracytoplasmic sperm injection (ICSI) has often been heralded as a ground-breaking technique that has transformed the treatment of couples with infertility. By injecting a single spermatozoon into the cytoplasm of the oocyte, ICSI bypasses the zona pellucida and increases the chances of fertilization and subsequent embryo development, independent of semen parameters. Ever since the first live births using ICSI were reported 1992, ICSI has become the mainstay of treating male factor infertility as well as overcoming fertilization failure associated with conventional in vitro insemination...
October 18, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29043705/quality-of-life-and-its-influencing-factors-of-couples-referred-to-an-infertility-center-in-shiraz-iran
#2
Bahia Namavar Jahromi, Mahsa Mansouri, Sedighe Forouhari, Tahere Poordast, Alireza Salehi
Background: Infertility adversely affects quality of life (QoL). The present study aims to evaluate QoL and its associated factors among infertile couples. MATERIALS AND METHODS: In this cross-sectional study, the Fertility QoL (FertiQoL) instrument was used to measure QoL among 501 volunteer couples who attended the Infertility Clinic at the Mother and Child Hospital, Shiraz, Iran. We used an additional questionnaire to assess participants' demographic and clinical characteristics...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29043699/multiplex-polymerase-chain-reaction-for-detecting-microdeletions-in-the-azoospermia-factor-region-of-y-chromosome-in-iranian-couples-with-non-obstructive-infertility-and-recurrent-pregnancy-loss
#3
Afsaneh Mojtabanezhad Shariatpanahi, Hassan Ahmadnia, Adam Torkamanzehi, Mahnaz Mansouri Torshizi, Mohammad Amin Kerachian
Background: Approximately 15% of couples are infertile with the male factor explaining approximately 50% of the cases. One of the main genetic factors playing a role in male infertility is Y chromosomal microdeletions within the proximal long arm of the Y chromosome (Yq11), named the azoospermia factor (AZF) region. Recent studies have shown there is a potential connection between deletions of the AZF region and recurrent pregnancy loss (RPL). The aim of this study is to examine this association by characterizing AZF microdeletions in two infertile groups: in men with non-obstructive infertility and in men with wives displaying RPL...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29040512/fertility-related-knowledge-and-reproductive-goals-in-childhood-cancer-survivors-short-communication
#4
V Lehmann, M C Keim, L Nahata, E L Shultz, J L Klosky, M A Tuinman, C A Gerhardt
STUDY QUESTION: Do young adult survivors of childhood cancer know their fertility status, in the context of their parenthood goals and screening for gonadal functioning? SUMMARY ANSWER: While 80% of survivors (who were without children) wanted children in the future, most did not know their fertility status, and screening for gonadal functioning was underutilized. WHAT IS KNOWN ALREADY: Survivors of childhood cancer are at risk for infertility, but fertility counseling and assessment are underutilized...
September 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29030775/improvement-in-pregnancy-outcomes-in-couples-with-immunologically-male-infertility-undergoing-prednisolone-treatment-and-conventional-in-vitro-fertilization-preceded-by-sperm-penetration-assay-a-randomized-controlled-trial
#5
Ahmed M Taiyeb, Mundhir T Ridha-Albarzanchi, Shereen M Taiyeb, Zuhair A Kanan, Shahla K Alatrakchi, Michael E Kjelland, Saeeda A Muhsen-Alanssari
PURPOSE: Anti-sperm antibodies (ASA) in men impair not only sperm motility but also fertilization and conception. However, utilization of corticosteroids to suppress ASA has shown variable pregnancy outcomes. This controversy is also extended to include the usefulness of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in treatments of men with ASA. This study was therefore designed to define factors contributing to these inconsistent results. METHODS: Infertile men having ASA (n = 241) were randomly assigned for treatment with or without prednisolone for three cycles each of 21 days of their partner's menstrual cycles...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29029549/progress-and-future-prospect-of-in-vitro-spermatogenesis
#6
REVIEW
Fahar Ibtisham, Jiang Wu, Mei Xiao, Lilong An, Zachary Banker, Aamir Nawab, Yi Zhao, Guanghui Li
Infertility has become a major health issue in the world. It affects the social life of couples and of all infertility cases; approximately 40-50% is due to "male factor" infertility. Male infertility could be due to genetic factors, environment or due to gonadotoxic treatment. Developments in reproductive biotechnology have made it possible to rescue fertility and uphold biological fatherhood. In vitro production of haploid male germ cell is a powerful tool, not only for the treatment of infertility including oligozoospermic or azoospermic patient, but also for the fertility preservation in pre-pubertal boys whose gonadal function is threatened by gonadotoxic therapies...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029094/thyroid-hormone-metabolism-defects-in-a-mouse-model-of-sbp2-deficiency
#7
Jiao Fu, Haruki Fujisawa, Benjamin Follman, Xiao-Hui Liao, Alexandra M Dumitrescu
SBP2 (selenocysteine insertion sequence binding protein 2) is an essential factor in selenoprotein synthesis. Patients with SBP2 defects have a characteristic thyroid phenotype and additional manifestations such as growth delay, male infertility, impaired motor coordination and developmental delay. The thyroid phenotype has become pathognomonic for this defect and putative deficiencies in the iodothyronine deiodinases selenoenzymes have been implicated. To investigate the role of SBP2 and selenoproteins in thyroid physiology and answer questions raised by the human syndrome we generated a tamoxifen inducible Sbp2 conditional knockout (iCKO) mouse model...
September 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#8
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29025010/sperm-function-protein-phosphorylation-and-metabolism-differ-in-mice-lacking-successive-sperm-specific-glycolytic-enzymes
#9
Zaohua Huang, Polina V Danshina, Kathleen Mohr, Weidong Qu, Summer G Goodson, Thomas M O'Connell, Deborah A O'Brien
Glyceraldehyde 3-phosphate dehydrogenase-S (GAPDHS) and phosphoglycerate kinase 2 (PGK2), two isozymes restricted to the male germline, catalyze successive steps in the glycolytic pathway in mammalian sperm. Although gene targeting of each isozyme demonstrated that glycolysis is required for normal sperm motility and male fertility, the phenotype of mice lacking GAPDHS is more severe than that of mice lacking PGK2. This study examined sperm function, signaling pathways and metabolism to investigate factors that contribute to the phenotypic differences between these knockout models...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024992/formation-and-function-of-sperm-tail-structures-in-association-with-sperm-motility-defects
#10
Mari S Lehti, Anu Sironen
Male infertility is an increasing problem partly due to inherited genetic variations. Mutations in genes involved in formation of the sperm tail cause motility defects and thus male infertility. Therefore it is crucial to understand the protein networks required for sperm differentiation. Sperm motility is produced through activation of the sperm flagellum, which core structure, the axoneme, resembles motile cilia. In addition to this cytoskeletal axonemal structure sperm tail motility requires various accessory structures...
August 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024157/regulation-of-nonylphenol-induced-reproductive-toxicity-in-mouse-spermatogonia-cells-by-mir-361-3p
#11
Liyan Tang, Bo Zhao, Hui Zhang, Qiao Du, Jiang Zhu, Zhijiang Zhao, Ce Chen, Cheng Luo, Qiyuan Kang, Wenbing Yuan, Shaohua Bian, Hang Bi, Huimin Sun, Yingyi Li
Nonylphenol (NP) is an environmental chemical that affects apoptosis and male infertility. In our study, we found that a high concentration of NP could down-regulate the expression of microRNA-361-3p (miR-361-3p) in the murine GC-1 spermatogonia cell line and in vivo in murine spermatogonia. Additionally, one direct target of this miR, the 3' untranslated region of Killin (Klln) mRNA, was identified. Klln encodes a transcription factor that directly regulates the expression of Tp73 (transcriptionally active p73), whose encoded protein can up-regulate the expression of Puma (P53 upregulated modulator of apoptosis)...
October 12, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29023053/effect-of-antioxidants-on-testicular-inos-and-enos-after-high-fat-diet-in-rat
#12
Maryam Sohrabi, Mahnaz Hosseini, Sevinc Inan, Zohreh Alizadeh, Mehrangiz Vahabian, Ali Asghar Vahidinia, Hosein Lahoutian
BACKGROUND AND OBJECTIVE: Spermatogenesis is a process by which germ cells produce spermatozoa and can be disturbed at every level. Nitric Oxide Synthases (NOS), implicate in interactions with Oxidative Stress (OS) which is one of the main factors in the etiology of male infertility. The High Fat Diet (HFD) is a major factor of obesity which in turn is important for enhancing OS. Antioxidants and garlic could attenuate or reverse effects of HFD. The aim of the study was to investigate the effects of dietary antioxidants and garlic on testicular inducible NOS (iNOS) and endothelial NOS (eNOS) in Wistar albino rats fed on HFD...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/28991497/polymorphisms-of-dna-repair-genes-xrcc1-and-lig4-and-idiopathic-male-infertility
#13
Hadi Ghasemi, Iraj Khodadadi, Amir Fattahi, Abbas Moghimbeigi, Heidar Tavilani
Sperm DNA damage is one of the associated factors of idiopathic male infertility and abnormal spermatogenesis. This study was conducted to assess possible association between risk of male infertility with X-ray repair cross complementing group 1 (XRCC1) Arg399Gln (G to A) and DNA ligase 4 (LIG4) Thr9Ile (C to T) gene polymorphisms which are involved in different DNA repair pathways. In this case-control study 191 fertile and 191 infertile men (29-40 years old) were enrolled. The single-nucleotide polymorphism genotypes and alleles of XRCC1 Arg399Gln and LIG4 Thr9Ile were assessed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique...
October 9, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28981651/the-diagnosis-of-male-infertility-an-analysis-of-the-evidence-to-support-the-development-of-global-who-guidance-challenges-and-future-research-opportunities
#14
Christopher L R Barratt, Lars Björndahl, Christopher J De Jonge, Dolores J Lamb, Francisco Osorio Martini, Robert McLachlan, Robert D Oates, Sheryl van der Poel, Bianca St John, Mark Sigman, Rebecca Sokol, Herman Tournaye
BACKGROUND: Herein, we describe the consensus guideline methodology, summarize the evidence-based recommendations we provided to the World Health Organization (WHO) for their consideration in the development of global guidance and present a narrative review of the diagnosis of male infertility as related to the eight prioritized (problem or population (P), intervention (I), comparison (C) and outcome(s) (O) (PICO)) questions. Additionally, we discuss the challenges and research gaps identified during the synthesis of this evidence...
July 19, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28977892/polymorphisms-of-protamine-genes-contribute-to-male-infertility-susceptibility-in-the-chinese-han-population
#15
Weijun Jiang, Peiran Zhu, Jing Zhang, Qiuyue Wu, Weiwei Li, Shuaimei Liu, Mengxia Ni, Maomao Yu, Jin Cao, Yi Li, Yingxia Cui, Xinyi Xia
Protamine (PRM) plays important roles in the packaging of DNA within the sperm nucleus. To investigate the role of PRM1/2 and transition protein 1 (TNP1) polymorphisms in male infertility, 636 infertile men and 442 healthy individuals were recruited into this case-controlled study of the Chinese Han population, using MassARRAY technology to analyze genotypes. Our analysis showed that there were no significant differences between controls and infertile cases among the five single nucleotide polymorphisms identified in PRM1, PRM2 and TNP1 [rs737008 (G/A), rs2301365 (C/A), rs2070923 (C/A), rs1646022 (C/G) and rs62180545 (A/G)]...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977108/overcoming-male-factor-infertility-with-intracytoplasmic-sperm-injection
#16
Edson Borges, Bianca Ferrarini Zanetti, Daniela Paes de Almeida Ferreira Braga, Amanda Souza Setti, Rita de Cássia Sávio Figueira, Aguinaldo César Nardi, Assumpto Iaconelli
OBJECTIVE: To evaluate the effect of male factor infertility on intracytoplasmic sperm injection (ICSI) outcomes compared with a control group presenting isolated tubal factor. METHOD: This retrospective study included 743 couples undergoing ICSI as a result of isolated male factor and a control group consisting of 179 couples undergoing ICSI as a result of isolated tubal factor, performed in a private university- -affiliated in vitro fertilization center, between January/2010 and December/2016...
August 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28969154/gene-scanning-for-microdeletions-in-the-azoospermia-factor-region-of-y-chromosome-in-infertile-men-of-gujarat-india
#17
Mili Nailwal, Jenabhai B Chauhan
INTRODUCTION: Azoospermia Factor (AZF) microdeletions in Yq chromosome is one of the most frequent genetic cause associated with failure of spermatogenesis in males with infertility. AIM: To figure out the Yq chromosome microdeletions frequency in infertile men from Gujarat region of India. MATERIALS AND METHODS: In this study, 141 infertile men with azoospermia (n=41) and oligozoospermia (n=100) were examined along with 159 normozoospermic men...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28954206/phospholipase-c-zeta-parameters-in-sperm-from-polymorphic-teratozoospermic-men
#18
Nahid Azad, Hamid Nazarian, Marefat Ghaffari Novin, Reza Masteri Farahani, Abbas Piryaei, Mohammad Hassan Heidari
Teratozoospermia is a disorder associated with high abnormal sperm morphology which affects fertility in males. In recent years, it has been described that biomarker-based sperm quality evaluation can alleviate male infertility treatment. Phospholipase C zeta (PLCζ) is a sperm-specific factor which appears to be a predicting biomarker for fertilization potential of males. Following fertilization, PLCζ enters into oocyte cytoplasm and induces oocyte activation, a fundamental stage in initiation of embryo development...
September 24, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28952695/-effects-of-smoking-and-alcohol-consumptionon-reproductive-and-metabolic-indicators-in-young-men-in-western-siberia
#19
L V Osadchuk, A V Popova, A A Erkovich, N A Voroshilova, A V Osadchuk
INTRODUCTION: Smoking and alcohol consumption remain widespread throughout the world, including Russia. Recently, due to the increase in male infertility and subfertility, special attention has been paid to the effects of smoking and alcohol on the reproductive health of young men. The aim of this study was to assess the effects of smoking and moderate alcohol consumption on spermatogenesis, reproductive hormone levels and metabolic status in young men living in Western Siberia (Novosibirsk)...
September 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28951884/use-of-exogenous-testosterone-for-the-treatment-of-male-factor-infertility-a-survey-of-nigerian-doctors
#20
Olufunmilade Akinfolarin Omisanjo, Stephen Odunayo Ikuerowo, Moruf Adekunle Abdulsalam, Sheriff Olabode Ajenifuja, Khadijah Adebisi Shittu
BACKGROUND: Though exogenous testosterone is known for its contraceptive effects in men, it is sometimes prescribed by medical practitioners for the treatment of male factor infertility in the mistaken belief that exogenous testosterone improves sperm count. The aim of this study was to evaluate the scope of testosterone use in the treatment of male factor infertility by medical practitioners in Lagos, Nigeria. METHODS: A survey using a structured questionnaire was carried out amongst doctors attending a regular Continuing Medical Education (CME) programme in Lagos, Nigeria...
2017: International Journal of Reproductive Medicine
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