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https://www.readbyqxmd.com/read/29237289/safely-converting-an-entire-academic-medical-center-from-sliding-scale-to-basal-bolus-insulin-via-implementation-of-the-eglycemic-management-system
#1
Rosalina Newsom, Christopher Patty, Emma Camarena, Regina Sawyer, Raymie McFarland, Thomas Gray, Melanie Mabrey
OBJECTIVE: Hyperglycemia is common in the inpatient setting and providers frequently rely on sliding scale insulin. This case study reviews the experience of one hospital moving from high utilization of sliding scale to basal bolus insulin therapy. METHOD: This Retrospective Quality Improvement Study describes the journey of clinicians at a 580-bed hospital to convert from high usage of SSI to BBI. Hyperglycemic adult patients prescribed insulin, with/without a diagnosis of diabetes, were included...
December 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29214466/large-scale-dna-organization-is-a-prognostic-marker-of-breast-cancer-survival
#2
Martial Guillaud, Qian Ye, Sam Leung, Anita Carraro, Alan Harrison, Malcolm Hayes, Alan Nichol, Mira Keyes
Breast cancer is the leading cause of cancer-related deaths among women worldwide. We investigated whether changes in large-scale DNA organization (LDO) of tumor epithelial nuclei are an indicator of the aggressiveness of the tumor. We tested our algorithm on a set of 172 duplicates TMA cores samples coming from 95 breast cancer patients. Thirty-five patients died of breast cancer, and 60 were still alive 10 years after surgery. Duplicates cores were used to create training and test set. The TMA slides were stained with Feulgen-thionin and imaged using our in-house high-resolution Imaging system...
December 6, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29200487/morton-s-neuroma-interdigital-neuralgia-treated-with-metatarsal-sliding-osteotomy
#3
Joonho Lee, Jeongyo Kim, Myoungjin Lee, Intak Chu, Sungjae Lee, Heuichul Gwak
Background: Morton's neuroma is a common cause of metatarsalgia and many treatments had been described in literature. However, there have been only a few reports that treat the neuroma with an osteotomy on the proximal, not distal portion of the metatarsal bone using a plate. This study describes the clinical outcome of sliding osteotomy on the proximal metatarsal bone for the treatment of Morton's neuroma. Materials and Methods: Sixty five consecutive patients (85 feet) who underwent surgery for Morton's neuroma between November 2010 and February 2013 were identified from hospital records to include in this retrospective study...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29190097/stick-slip-instabilities-for-interfacial-chemical-bond-induced-friction-at-the-nanoscale
#4
Kaiwen Tian, Nitya Nand Gosvami, David L Goldsby, Robert W Carpick
Earthquakes are generally caused by unstable stick-slip motion of rocks at faults. This stick-slip phenomenon, along with other frictional properties of materials at the macroscale, are well-described by empirical rate and state friction (RSF) laws. Here we show stick-slip behavior for nanoscale single-asperity silica-silica contacts. The stick-slip is quasi-periodic, and both the amplitude and spatial period of stick-slip increase with normal load and decrease with the loading point (i.e., scanning) velocity...
November 30, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29186756/robust-vehicle-detection-in-aerial-images-based-on-cascaded-convolutional-neural-networks
#5
(no author information available yet)
Vehicle detection in aerial images is an important and challenging task. Traditionally, many target detection models based on sliding-window fashion were developed and achieved acceptable performance, but these models are time-consuming in the detection phase. Recently, with the great success of convolutional neural networks (CNNs) in computer vision, many state-of-the-art detectors have been designed based on deep CNNs. However, these CNN-based detectors are inefficient when applied in aerial image data due to the fact that the existing CNN-based models struggle with small-size object detection and precise localization...
November 24, 2017: Sensors
https://www.readbyqxmd.com/read/29162811/evolution-of-tribo-induced-interfacial-nanostructures-governing-superlubricity-in-a-c-h-and-a-c-h-si-films
#6
Xinchun Chen, Chenhui Zhang, Takahisa Kato, Xin-An Yang, Sudong Wu, Rong Wang, Masataka Nosaka, Jianbin Luo
Hydrogenated amorphous carbon (a-C:H) is capable of providing a near-frictionless lubrication state when rubbed in dry sliding contacts. Nevertheless, the mechanisms governing superlubricity in a-C:H are still not well comprehended, mainly due to the lack of spatially resolved structural information of the buried contact surface. Here, we present structural analysis of the carbonaceous sliding interfaces at the atomic scale in two superlubricious solid lubricants, a-C:H and Si-doped a-C:H (a-C:H:Si), by probing the contact area using state-of-the-art scanning electron transmission microscopy and electron energy-loss spectroscopy...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29155743/snap-chip-for-cross-reactivity-free-and-spotter-free-multiplexed-sandwich-immunoassays
#7
Huiyan Li, Sebastien Bergeron, Heidi Larkin, David Juncker
Multiplexed protein analysis has shown superior diagnostic sensitivity and accuracy compared to single proteins. Antibody microarrays allow for thousands of micro-scale immunoassays performed simultaneously on a single chip. Sandwich assay format improves assay specificity by detecting each target with two antibodies, but suffers from cross-reactivity between reagents thus limiting their multiplexing capabilities. Antibody colocalization microarray (ACM) has been developed for cross-reactivity-free multiplexed protein detection, but requires an expensive spotter on-site for microarray fabrication during assays...
November 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29149657/the-mechanical-behavior-of-nacre-across-length-scales
#8
Hariprasad Gopalan, Atul H Chokshi
Nacre achieves excellent mechanical properties with a relatively simple hierarchical structure. Analyses suggest that a significant gain in toughness is realized with a modest reduction in strength, with increasing levels of hierarchy. This study probes the role of different hierarchical length scales in governing the strength and modulus of nacre using a combination of bulk compression tests, microindentation and nanoindentation tests. The variability in the measured properties is assessed through Weibull analyses...
October 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29143321/interobserver-agreement-on-standardized-ultrasound-and-histopathologic-signs-for-the-prenatal-diagnosis-of-placenta-accreta-spectrum-disorder
#9
Nurit Zosmer, Eric Jauniaux, Catey Bunce, Jenie Panaiotova, Hizbullah Shaikh, Kypros H Nicholaides
OBJECTIVE: To evaluate interobserver agreement in assessment of ultrasound signs and histopathologic findings associated with placenta accreta spectrum (PAS) disorders. METHODS: A retrospective study was conducted using data for patients prenatally diagnosed with PAS disorders at a UK hospital between January 31, 2012, and March 30, 2017. Ultrasound images (including gray-scale and color Doppler imaging [CDI] parameters) and histopathologic slides were reviewed by two observers; the level of agreement was calculated...
November 16, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29132105/viscoelastic-drops-moving-on-hydrophilic-and-superhydrophobic-surfaces
#10
H Xu, A Clarke, J P Rothstein, R J Poole
So-called "superhydrophobic" surfaces are strongly non-wetting such that fluid droplets very easily roll off when the surface is tilted. Our interest here is in understanding if this is also true, all else held equal, for viscoelastic fluid drops. We study the movement of Newtonian and well-characterised constant-viscosity elastic liquids when various surfaces, including hydrophilic (smooth glass), weakly hydrophobic (embossed polycarbonate) and superhydrophobic surfaces (embossed PTFE), are impulsively tilted...
October 28, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29128701/quality-evaluation-of-sperm-from-livebearing-fishes-standardized-assessment-of-sperm-bundles-spermatozeugmata-from-xenotoca-eiseni-goodeidae
#11
Yue Liu, Leticia Torres, Terrence R Tiersch
Standardized evaluation of sperm quality is essential for research, commercial-scale cryopreservation, and induced spawning. However, standardized methods for evaluation of sperm bundles (spermatozeugmata or spermatophores) have not been established. The purpose of the present study was to use Redtail Splitfin (Xenotoca eiseni) as a model for freshwater livebearing fishes to establish initial standardized methods to collect sperm bundles, and quantitatively and qualitatively evaluate quality-related attributes...
October 28, 2017: Theriogenology
https://www.readbyqxmd.com/read/29121926/quantitative-and-qualitative-aspects-of-standing-up-behavior-and-the-prevalence-of-osteochondrosis-in-warmblood-foals-on-different-farms-could-there-be-a-link
#12
E M van Grevenhof, A R D Gezelle Meerburg, M C van Dierendonck, A J M van den Belt, B van Schaik, P Meeus, W Back
BACKGROUND: Osteochondrosis (OC) is a common, clinically important joint disorder in which endochondral ossification is focally disturbed. Reduced blood supply to growing cartilage is considered an important cause of the condition, which has both genetic and environmental origins. Housing conditions can influence cartilage injury through peak-pressure changes during limb sliding. Additionally, circulatory perturbation can cause the avascular necrosis of cartilage. In this study, we evaluated the type and frequency of limb sliding during standing up and the occurrence of OC in foals aged up to 12 months on different farms...
November 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29121110/symmetry-recognition-by-pigeons-generalized-or-not
#13
Juan D Delius, Julia A M Delius, Jennifer M Lee
This note looks into the reasons why earlier reports may have arrived at differing conclusions about pigeons' capacity to categorize bilaterally symmetric and asymmetric visual patterns. Attention is drawn to pigeons' comparatively superior visual flicker resolution and superior visual linear acuity by reporting results of two ad-hoc experiments. This circumstance turns out to constrain conclusions drawn by earlier symmetry-asymmetry studies that used computer-generated patterns displayed on cathode ray tube monitors as these suffered from pictorial distortions...
2017: PloS One
https://www.readbyqxmd.com/read/29116758/robust-stacking-independent-ultrafast-charge-transfer-in-mos2-ws2-bilayers
#14
Ziheng Ji, Hao Hong, Jin Zhang, Qi Zhang, Wei Huang, Ting Cao, Ruixi Qiao, Can Liu, Jing Liang, Chuanhong Jin, Liying Jiao, Kebin Shi, Sheng Meng, Kaihui Liu
Van der Waals-coupled two-dimensional (2D) heterostructures have attracted great attentions recently due to their high potential in the next-generation photodetectors and solar cells. The understanding of charge-transfer process between adjacent atomic layers is the key to design optimal devices as it directly determines the fundamental response speed and photon-electron conversion efficiency. However, general belief and theoretical studies have shown that the charge transfer behaviour depends sensitively on interlayer configurations, which is difficult to control accurately, bringing great uncertainties in device designing...
November 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/29116744/transforming-a-simple-commercial-glue-into-highly-robust-superhydrophobic-surfaces-via-aerosol-assisted-chemical-vapor-deposition
#15
Aoyun Zhuang, Ruijin Liao, Yao Lu, Sebastian C Dixon, Arreerat Jiamprasertboon, Faze Chen, Sanjayan Sathasivam, Ivan P Parkin, Claire J Carmalt
Robust superhydrophobic surfaces were synthesized as composites of the widely commercially available adhesives epoxy resin (EP) and polydimethylsiloxane (PDMS). The EP layer provided a strongly adhered micro/nanoscale structure on the substrates, while the PDMS was used as a post-treatment to lower the surface energy. In this study, the depositions of EP films were taken at a range of temperatures, deposition times, and substrates via aerosol-assisted chemical vapor deposition (AACVD). A novel dynamic deposition temperature approach was developed to create multiple-layered periodic micro/nanostructures that significantly improved the surface mechanical durability...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29114445/velocity-dependence-of-sliding-friction-on-a-crystalline-surface
#16
Christian Apostoli, Giovanni Giusti, Jacopo Ciccoianni, Gabriele Riva, Rosario Capozza, Rosalie Laure Woulaché, Andrea Vanossi, Emanuele Panizon, Nicola Manini
We introduce and study a minimal 1D model for the simulation of dynamic friction and dissipation at the atomic scale. This model consists of a point mass (slider) that moves over and interacts weakly with a linear chain of particles interconnected by springs, representing a crystalline substrate. This interaction converts a part of the kinetic energy of the slider into phonon waves in the substrate. As a result, the slider experiences a friction force. As a function of the slider speed, we observe dissipation peaks at specific values of the slider speed, whose nature we understand by means of a Fourier analysis of the excited phonon modes...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29114058/filament-rigidity-and-connectivity-tune-the-deformation-modes-of-active-biopolymer-networks
#17
Samantha Stam, Simon L Freedman, Shiladitya Banerjee, Kimberly L Weirich, Aaron R Dinner, Margaret L Gardel
Molecular motors embedded within collections of actin and microtubule filaments underlie the dynamics of cytoskeletal assemblies. Understanding the physics of such motor-filament materials is critical to developing a physical model of the cytoskeleton and designing biomimetic active materials. Here, we demonstrate through experiments and simulations that the rigidity and connectivity of filaments in active biopolymer networks regulates the anisotropy and the length scale of the underlying deformations, yielding materials with variable contractility...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29113634/pharmacy-diabetes-management-of-a-veteran-population-in-a-long-term-care-setting-a-program-evaluation
#18
Forest Hansen, Hilary Teeples, Jordan Csati, Suzanne M Gillespie
BACKGROUND: The benefits of an outpatient pharmacy diabetes clinic has been established, with improved patient outcomes and reduced total costs of care. We describe the benefits of an inpatient clinical pharmacy diabetes service within a Department of Veterans Affairs long-term care facility. METHODS: Patients were referred to the pharmacy diabetes monitoring program between February 2016 and August 2016. During this time, clinical pharmacy specialists managed all pharmacotherapy relating to diabetes care as well as all fingerstick monitoring frequencies and laboratory monitoring to achieve a prespecified, patient-specific A1C goal...
November 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29111585/tear-ferning-test-in-healthy-dogs
#19
Arianne P Oriá, Ana Claudia S Raposo, Nayone L L C Araújo, Felipe B Lima, Ali M Masmali
PURPOSE: To evaluate and compare three tear sampling methods using two grading scales for administering the tear ferning test (TFT) to healthy dogs. METHODS: In total, 90 dogs (180 eyes) were subjected to tear sampling using millimetered strips, reused after the Schirmer tear test (STT) (Schirmer group, SG). Then, the dogs were subdivided into three groups according to sampling approach: micropipette (MPG), microcapillary (MCG), and Schirmer sample 2 (S2G). The collected tears were dried on a clean microscope glass slide at room temperature and humidity...
November 7, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29109450/interactive-phenotyping-of-large-scale-histology-imaging-data-with-histomicsml
#20
Michael Nalisnik, Mohamed Amgad, Sanghoon Lee, Sameer H Halani, Jose Enrique Velazquez Vega, Daniel J Brat, David A Gutman, Lee A D Cooper
Whole-slide imaging of histologic sections captures tissue microenvironments and cytologic details in expansive high-resolution images. These images can be mined to extract quantitative features that describe tissues, yielding measurements for hundreds of millions of histologic objects. A central challenge in utilizing this data is enabling investigators to train and evaluate classification rules for identifying objects related to processes like angiogenesis or immune response. In this paper we describe HistomicsML, an interactive machine-learning system for digital pathology imaging datasets...
November 6, 2017: Scientific Reports
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