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https://www.readbyqxmd.com/read/28067472/efficacy-of-basal-bolus-insulin-regimens-in-the-inpatient-management-of-non-critically-ill-patients-with-type-2-diabetes-a-systematic-review-and-meta-analysis
#1
REVIEW
Merete B Christensen, Anders Gotfredsen, Kirsten Nørgaard
BACKGROUND: Hyperglycemia during hospitalization is associated with increased rates of complications and longer hospital stays. Various insulin regimens are used in the inpatient diabetes management of non-critically ill patients. We aimed to assess the efficacy and safety of basal-bolus insulin therapy (BBI) by summarizing evidence from studies of BBI versus sliding scale insulin therapy (SSI) in the management of hospitalized non-critically ill type 2 diabetes patients. METHODS: We searched MEDLINE, EMBASE, Scopus and the Cochrane Library for studies comparing BBI therapy with SSI therapy in hospitalized non-critically ill patients with type 2 diabetes...
January 9, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28062822/improving-health-care-for-spanish-speaking-rural-dairy-farm-workers
#2
Caledonia Buckheit, Dwan Pineros, Ardis Olson, Deborah Johnson, Stephen Genereaux
BACKGROUND: Dartmouth Geisel Migrant Health (DGMH) is a medical student group that provides on-site health services for Spanish-speaking dairy workers in rural Vermont and New Hampshire in conjunction with a federally qualified health center (FQHC). STUDY OBJECTIVE: This project was undertaken to evaluate and improve the services provided by DGMH and the FQHC and to refine understanding of the target population. METHODS: We surveyed 25 workers at 6 collaborating dairy farms to identify health priorities and concerns and perceived barriers and facilitators to health care for these workers...
January 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28060141/pd-l1-expression-in-premalignant-and-malignant-trophoblasts-from-gestational-trophoblastic-diseases-is-ubiquitous-and-independent-of-clinical-outcomes
#3
Pierre-Adrien Bolze, Sophie Patrier, Jérôme Massardier, Touria Hajri, Fatima Abbas, Anne Marie Schott, Fabienne Allias, Mojgan Devouassoux-Shisheboran, Gilles Freyer, François Golfier, Benoît You
OBJECTIVE: Recently reported expression of programmed cell death 1 ligand 1 (PD-L1) in gestational trophoblastic diseases (GTDs) suggests that the immune tolerance of pregnancy might be hijacked during neoplastic process. We assessed PD-L1 protein expression in premalignant and malignant GTD lesions and analyzed associations with disease severity and chemotherapy outcomes. METHODS: We included 83 GTD whole-tissue sections from 76 patients in different treatment settings...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28056784/t-recs-rapid-and-large-scale-detection-of-recombination-events-among-different-evolutionary-lineages-of-viral-genomes
#4
Michail Tsimpidis, Georgios Bachoumis, Kalliopi Mimouli, Zaharoula Kyriakopoulou, David L Robertson, Panayotis Markoulatos, Grigoris D Amoutzias
BACKGROUND: Many computational tools that detect recombination in viruses are not adapted for the ongoing genomic revolution. A computational tool is needed, that will rapidly scan hundreds/thousands of genomes or sequence fragments and detect candidate recombination events that may later be further analyzed with more sensitive and specialized methods. RESULTS: T-RECs, a Windows based graphical tool, employs pairwise alignment of sliding windows and can perform (i) genotyping, (ii) clustering of new genomes, (iii) detect recent recombination events among different evolutionary lineages, (iv) manual inspection of detected recombination events by similarity plots and (v) annotation of genomic regions...
January 5, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28052046/fast-approximate-delivery-of-fluence-maps-for-imrt-and-vmat
#5
Marleen Balvert, David L Craft
In this article we provide a method to generate the trade-off between delivery time and fluence map matching quality for dynamically delivered fluence maps. At the heart of our method lies a mathematical programming model that, for a given duration of delivery, optimizes leaf trajectories and dose rates such that the desired fluence map is reproduced as well as possible. We begin with the single fluence map case and then generalize the model and the solution technique to the delivery of sequential fluence maps...
January 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28029354/-idem-depression-characteristics-and-evaluation-of-an-open-group-that-combines-psychoeducation-and-cognitive-behavior-therapy
#6
L Weiner, E Garcia-Krafes, S Garcia, C Berthomier, A Morali, J-Y Metzger, S Weibel, H Javelot, G Bertschy
INTRODUCTION: Depression is a highly prevalent mental illness that is associated with high rates of morbidity and functional impairment. At the psychiatric unit of the University Hospital of Strasbourg, France, we have developed an open group that combines psychoeducation and cognitive-behavior therapy (CBT), the information, discovery, exchange and mobilization for depression group (IDEM-depression). IDEM-depression is composed of 17 thematic, structured, and independent sessions, which address different aspects of depression (i...
October 28, 2016: L'Encéphale
https://www.readbyqxmd.com/read/28026931/mechanochemistry-at-solid-surfaces-polymerization-of-adsorbed-molecules-by-mechanical-shear-at-tribological-interfaces
#7
Jejoon Yeon, Xin He, Ashlie Martini, Seong H Kim
Polymerization of allyl alcohol adsorbed and sheared at a silicon oxide interface is studied using tribo-tests in vapor phase lubrication conditions and reactive molecular dynamics simulations. The load dependences of product formation obtained from experiments and simulations were consistent, indicating that the atomic-scale processes observable in the simulations were relevant to the experiments. Analysis of the experimental results in the context of mechanically-assisted thermal reaction theory, combined with the atomistic detail available from the simulations, suggested that the association reaction pathway of allyl alcohol molecules induced by mechanical shear is quite different from chemically-induced polymerization reactions...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28025302/micromechanics-of-sea-ice-frictional-slip-from-test-basin-scale-experiments
#8
Peter R Sammonds, Daniel C Hatton, Daniel L Feltham
We have conducted a series of high-resolution friction experiments on large floating saline ice floes in an environmental test basin. In these experiments, a central ice floe was pushed between two other floes, sliding along two interfacial faults. The frictional motion was predominantly stick-slip. Shear stresses, normal stresses, local strains and slip displacement were measured along the sliding faults, and acoustic emissions were monitored. High-resolution measurements during a single stick-slip cycle at several positions along the fault allowed us to identify two phases of frictional slip: a nucleation phase, where a nucleation zone begins to slip before the rest of the fault, and a propagation phase when the entire fault is slipping...
February 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28002055/sliding-friction-in-the-hydrodynamic-lubrication-regime-for-a-power-law-fluid
#9
P B Warren
A scaling analysis is undertaken for the load balance in sliding friction in the hydrodynamic lubrication regime, with a particular emphasis on power-law shear-thinning typical of a structured liquid. It is argued that the shear-thinning regime is mechanically unstable if the power-law index n  <  1/2, where n is the exponent that relates the shear stress to the shear rate. Consequently the Stribeck (friction) curve should be discontinuous, with possible hysteresis. Further analysis suggests that normal stress and flow transience (stress overshoot) do not destroy this basic picture, although they may provide stabilising mechanisms at higher shear rates...
February 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27997373/depinning-and-nonequilibrium-dynamic-phases-of-particle-assemblies-driven-over-random-and-ordered-substrates-a-review
#10
C Reichhardt, C J Olson Reichhardt
We review the depinning and nonequilibrium phases of collectively interacting particle systems driven over random or periodic substrates. This type of system is relevant to vortices in type-II superconductors, sliding charge density waves, electron crystals, colloids, stripe and pattern forming systems, and skyrmions, and could also have connections to jamming, glassy behaviors, and active matter. These systems are also ideal for exploring the broader issues of characterizing transient and steady state nonequilibrium flow phases as well as nonequilibrium phase transitions between distinct dynamical phases, analogous to phase transitions between different equilibrium states...
December 20, 2016: Reports on Progress in Physics
https://www.readbyqxmd.com/read/27994941/a-multisite-validation-of-whole-slide-imaging-for-primary-diagnosis-using-standardized-data-collection-and-analysis
#11
Katy Wack, Laura Drogowski, Murray Treloar, Andrew Evans, Jonhan Ho, Anil Parwani, Michael C Montalto
CONTEXT: Text-based reporting and manual arbitration for whole slide imaging (WSI) validation studies are labor intensive and do not allow for consistent, scalable, and repeatable data collection or analysis. OBJECTIVE: The objective of this study was to establish a method of data capture and analysis using standardized codified checklists and predetermined synoptic discordance tables and to use these methods in a pilot multisite validation study. METHODS AND STUDY DESIGN: Fifteen case report form checklists were generated from the College of American Pathology cancer protocols...
2016: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/27974575/microstructural-and-geometric-influences-in-the-protective-scales-of-atractosteus-spatula
#12
Vincent R Sherman, Nicholas A Yaraghi, David Kisailus, Marc A Meyers
Atractosteus spatula has been described as a living fossil (having existed for 100 Myr), retaining morphological characteristics of early ancestors such as the ability to breathe air and survive above water for hours. Its highly effective armour consists of ganoid scales. We analyse the protective function of the scales and identify key features which lead to their resistance to failure. Microstructural features include: a twisted cross-plied mineral arrangement that inhibits crack propagation in the external ganoine layer, mineral crystals that deflect cracks in the bony region in order to activate the strength of mineralized collagen fibrils, and saw-tooth ridges along the interface between the two scale layers which direct cracks away from the intrinsically weak interface...
December 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27958267/imaging-high-speed-friction-at-the-nanometer-scale
#13
Per-Anders Thorén, Astrid S de Wijn, Riccardo Borgani, Daniel Forchheimer, David B Haviland
Friction is a complicated phenomenon involving nonlinear dynamics at different length and time scales. Understanding its microscopic origin requires methods for measuring force on nanometer-scale asperities sliding at velocities reaching centimetres per second. Despite enormous advances in experimental technique, this combination of small length scale and high velocity remain elusive. We present a technique for rapidly measuring the frictional forces on a single asperity over a velocity range from zero to several centimetres per second...
December 13, 2016: Nature Communications
https://www.readbyqxmd.com/read/27928867/reduction-of-medication-errors-related-to-sliding-scale-insulin-by-the-introduction-of-a-standardized-order-sheet
#14
Saki Harada, Akio Suzuki, Shohei Nishida, Ryo Kobayashi, Sayuri Tamai, Keisuke Kumada, Nobuo Murakami, Yoshinori Itoh
Insulin is frequently used for glycemic control. Medication errors related to insulin are a common problem for medical institutions. Here, we prepared a standardized sliding scale insulin (SSI) order sheet and assessed the effect of its introduction. Observations before and after the introduction of the standardized SSI template were conducted at Gifu University Hospital. The incidence of medication errors, hyperglycemia, and hypoglycemia related to SSI were obtained from the electronic medical records. The introduction of the standardized SSI order sheet significantly reduced the incidence of medication errors related to SSI compared with that prior to its introduction (12/165 [7...
December 7, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27928236/perception-of-laypeople-and-dental-professionals-of-smile-esthetics
#15
Aida Saffarpour, Maryam Ghavam, Anna Saffarpour, Rozita Dayani, Mohammad Javad Kharazi Fard
OBJECTIVES: This study aimed to assess and compare the perception of laypersons and dental professionals of smile esthetics based on two factors namely gingival display and alignment of teeth. MATERIALS AND METHODS: A total of 32 females were randomly selected among dental students in the International Campus of School of Dentistry, Tehran University of Medical Sciences (Tehran, Iran) with no previous history of esthetic dental work. Frontal photographs were obtained and cropped from the subnasal to menton areas of subjects to standardize the size of pictures...
March 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27916719/syringe-test-screening-of-microbial-gas-production-activity-cases-denitrification-and-biogas-formation
#16
Kjetill Østgaard, Viktoria Kowarz, Wang Shuai, Ingrid A Henry, Michal Sposob, Hildegunn Hegna Haugen, Rune Bakke
Mass produced plastic syringes may be applied as vessels for cheap, simple and large scale batch culture testing. As illustrated for the cases of denitrification and of biogas formation, metabolic activity was monitored by direct reading of the piston movement due to the gas volume formed. Pressure buildup due to friction was shown to be moderate. A piston pull and slide back routine can be applied before recording gas volume to minimize experimental errors due to friction. Inoculum handling and activity may be conveniently standardized as illustrated by applying biofilm carriers...
January 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27901546/poroelasticity-driven-lubrication-in-hydrogel-interfaces
#17
Erik R Reale, Alison C Dunn
It is widely accepted that hydrogel surfaces are slippery, and have low friction, but dynamic applied stresses alter the hydrogel composition at the interface as water is displaced. The induced osmotic imbalance of compressed hydrogel which cannot swell to equilibrium should drive the resistance to slip against it. This paper demonstrates the driving role of poroelasticity in the friction of hydrogel-glass interfaces, specifically how poroelastic relaxation of hydrogels increases adhesion. We translate the work of adhesion into an effective surface energy density that increases with the duration of applied pressure from 10 to 50 mJ m(-2), as measured by micro-indentation...
November 30, 2016: Soft Matter
https://www.readbyqxmd.com/read/27882973/the-evolving-quality-of-frictional-contact-with-graphene
#18
Suzhi Li, Qunyang Li, Robert W Carpick, Peter Gumbsch, Xin Z Liu, Xiangdong Ding, Jun Sun, Ju Li
Graphite and other lamellar materials are used as dry lubricants for macroscale metallic sliding components and high-pressure contacts. It has been shown experimentally that monolayer graphene exhibits higher friction than multilayer graphene and graphite, and that this friction increases with continued sliding, but the mechanism behind this remains subject to debate. It has long been conjectured that the true contact area between two rough bodies controls interfacial friction. The true contact area, defined for example by the number of atoms within the range of interatomic forces, is difficult to visualize directly but characterizes the quantity of contact...
24, 2016: Nature
https://www.readbyqxmd.com/read/27878999/experimental-evaluation-of-multiscale-tendon-mechanics
#19
REVIEW
Fei Fang, Spencer P Lake
Tendon's primary function is a mechanical link between muscle and bone. The hierarchical structure of tendon and specific compositional constituents are believed to be critical for proper mechanical function. With increased appreciation for tendon importance and the development of various technological advances, this review paper summarizes recent experimental approaches that have been used to study multiscale tendon mechanics, includes an overview of studies that have evaluated the role of specific tissue constituents, and also proposes challenges/opportunities facing tendon study...
November 23, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27872547/measuring-dental-students-preference-a-comparison-of-light-microscopy-and-virtual-microscopy-as-teaching-tools-in-oral-histology-and-pathology
#20
Ohoud Alotaibi, Dalal ALQahtani
OBJECTIVES: Light microscopy used to be the traditional modality of teaching histology and pathology disciplines. Recent advances and innovations in the information technology field have revolutionized the use of hard- and software in medical education. An example of such an innovation is the so-called virtual microscopy. Many schools have started to adopt virtual microscopy as a new method aimed at enhancing student learning. Nonetheless, few reports have described the experiences of introducing virtual microscopy in dental education...
October 2016: Saudi Dental Journal
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