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https://www.readbyqxmd.com/read/29470713/health-related-quality-of-life-in-patients-undergoing-cervico-thoracic-osteotomies-for-fixed-cervico-thoracic-kyphosis-in-patients-with-ankylosing-spondylitis
#1
Silviu Sabou, Hossein Mehdian, Dritan Pasku, Luca Boriani, Nasir A Quraishi
PURPOSE: Ankylosing spondylitis (AS) can result in severe cervico-thoracic kyphotic deformity (CTKD). Few studies have addressed the relationship between cervico-thoracic osteotomies in AS and health-related quality of life scores. The aim of this study is to evaluate the impact of cervico-thoracic osteotomy (CTO) on improving quality of life for patients with fixed CTKD. METHODS: A database of all patients who underwent a CTO for CTKD in patients with AS was created...
February 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29468315/comparative-study-of-two-spinous-process-sp-osteotomy-techniques-for-posterior-decompression-surgery-in-lumbar-spinal-stenosis-sp-base-versus-splitting-osteotomy
#2
Gun Woo Lee, Myun-Whan Ahn
PURPOSE: To compare the postoperative clinical and radiological outcomes of the SP base osteotomy versus SP splitting techniques for PD for treating LSS. METHODS: Of 139 patients who underwent PD surgery for LSS, 97 who met the study criteria were enrolled in the study. Group A comprised 53 patients who underwent SP base osteotomy, and group B included 44 patients who underwent SP splitting osteotomy. The primary study endpoint was intensity of lower back pain (LBP) and pain radiation to the lower extremities measured with the visual analogue scale (VAS)...
February 21, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29467933/determinants-of-variability-of-five-programmed-death-ligand-1-immunohistochemistry-assays-in-non-small-cell-lung-cancer-samples
#3
Ross A Soo, Joey Sze Yun Lim, Bernadette Reyna Asuncion, Zul Fazreen, Maria Cynthia Herrera, Mohd Feroz Mohd Omar, Nguyen Hoang Diem Phuong, Ju Ee Seet, Benhur Amanuel, Barry Iacopetta, David Byrne, Shona Hendry, Stephen Fox, Richie Soong
Programmed death ligand-1 (PD-L1) expression as determined by immunohistochemistry (IHC) is potentially predictive of clinical outcome. The aim of this study was to assess the concordance of reported PD-L1 IHC assays and investigate factors influencing variability. Consecutive sections from 20 non-small cell lung cancers (NSCLCs) comprising resection, core biopsy, cytology and pleural fluid samples underwent IHC with 5 different antibody/autostainer combinations: 22C3/Link48, 28-8/BOND-MAX, E1L3N/BOND-MAX, SP142/BenchMark and SP263/BenchMark...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463302/the-impact-of-pd-l1-on-survival-and-value-of-the-immune-check-point-inhibitors-in-non-small-cell-lung-cancer-proposal-policies-and-perspective
#4
Helmy M Guirgis
BACKGROUND: The impact of programmed death receptor-ligand1 (PD-L1) on costs and value of the immune check point inhibitors (ICPI) has received minimal attention. OBJECTIVES: 1- Design a sliding scale to grade survival in 2nd-line non-small-cell lung cancer (NSCLC). 2- Compare costs and value of Nivolumab (Nivo), Atezolizumab (Atezo) and Pembrolizumab (Pembro) vs. Docetaxel (Doc). METHODS: Previously reported median overall survival (OS) and prices posted by parent company were utilized...
February 20, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29460418/reliability-of-histologic-assessment-in-patients-with-eosinophilic-oesophagitis
#5
M J Warners, C A Ambarus, A J Bredenoord, J Verheij, G Y Lauwers, J C Walsh, D A Katzka, S Nelson, T van Viegen, G T Furuta, S K Gupta, L Stitt, G Zou, C E Parker, L M Shackelton, G R D Haens, W J Sandborn, E S Dellon, B G Feagan, M H Collins, V Jairath, R K Pai
BACKGROUND: The validity of the eosinophilic oesophagitis (EoE) histologic scoring system (EoEHSS) has been demonstrated, but only preliminary reliability data exist. AIM: Formally assess the reliability of the EoEHSS and additional histologic features. METHODS: Four expert gastrointestinal pathologists independently reviewed slides from adult patients with EoE (N = 45) twice, in random order, using standardised training materials and scoring conventions for the EoEHSS and additional histologic features agreed upon during a modified Delphi process...
February 20, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29458609/prediction-of-sliding-friction-coefficient-based-on-a-novel-hybrid-molecular-mechanical-model
#6
Xiaogang Zhang, Yali Zhang, Jianmei Wang, Chenxing Sheng, Zhixiong Li
Sliding friction is a complex phenomenon which arises from the mechanical and molecular interactions of asperities when examined in a microscale. To reveal and further understand the effects of micro scaled mechanical and molecular components of friction coefficient on overall frictional behavior, a hybrid molecular-mechanical model is developed to investigate the effects of main factors, including different loads and surface roughness values, on the sliding friction coefficient in a boundary lubrication condition...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29455007/embryoid-body-arrays-parallel-cryosectioning-of-spheroid-embryoid-body-samples-for-medium-through-put-analysis
#7
Ross Ferguson, Vasanta Subramanian
Three dimensional (3D) culture of mammalian cells is emerging as a powerful new tool to understand organogenesis as well as serve as models for diseases with implications for therapeutic evaluation. 3D cultures are referred to variously as spheroid, organoids or embryoid bodies. While many methods exist for large scale production of embryoid bodies or other spheroid cell aggregates, either at controlled sizes using microwell/micropatterned plates or uncontrolled sizes in suspension dishes, very few protocols exist for medium throughput analysis of differentiation at the histological level...
February 9, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29443495/dynamic-sliding-enhancement-on-friction-and-adhesion-of-graphene-graphene-oxide-and-fluorinated-graphene
#8
Xingzhong Zeng, Yitian Peng, Mengci Yu, Haojie Lang, Xing'an Cao, Kun Zou
Graphene and functionalized graphene are promising candidates as ultrathin solid lubricants to deal with the adhesion and friction in micro and nanoelectromechanical systems (MEMS/NEMS). Here, the dynamic friction and adhesion characteristics of pristine graphene (PG), graphene oxide (GO) and fluorinated graphene (FG) were comparatively studied using atomic force microscopy (AFM). The friction as a function of load shows nonlinear characteristic on GO with strong adhesion and linear characteristic on PG and FG with relatively weak adhesions...
February 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29443037/high-resolution-3d-imaging-of-the-human-pancreas-neuro-insular-network
#9
Elizabeth Butterworth, Wesley Dickerson, Vindhya Vijay, Kristina Weitzel, Julia Cooper, Eric W Atkinson, Jason E Coleman, Kevin J Otto, Martha Campbell-Thompson
Using traditional histological methods, researchers are hampered in their ability to image whole tissues or organs in large-scale 3D. Histological sections are generally limited to <20 µm as formalin fixed paraffin section on glass slides or <500 µm for free-floating fixed sections. Therefore, extensive efforts are required for serial sectioning and large-scale image reconstruction methods to recreate 3D for samples >500 µm using traditional methods. In addition, light scatters from macromolecules within tissues, particularly lipids, prevents imaging to a depth >150 µm with most confocal microscopes...
January 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29436069/tunable-tribotronic-dual-gate-logic-devices-based-on-2d%C3%A2-mos2-and-black-phosphorus
#10
Guoyun Gao, Bensong Wan, Xingqiang Liu, Qijun Sun, Xiaonian Yang, Longfei Wang, Caofeng Pan, Zhong Lin Wang
With the Moore's law hitting the bottleneck of scaling-down in size (below 10 nm), personalized and multifunctional electronics with an integration of 2D materials and self-powering technology emerge as a new direction of scientific research. Here, a tunable tribotronic dual-gate logic device based on a MoS2 field-effect transistor (FET), a black phosphorus FET and a sliding mode triboelectric nanogenerator (TENG) is reported. The triboelectric potential produced from the TENG can efficiently drive the transistors and logic devices without applying gate voltages...
February 13, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29436032/graphene-graphene-interactions-friction-superlubricity-and-exfoliation
#11
Robert C Sinclair, James L Suter, Peter V Coveney
Graphite's lubricating properties due to the "weak" interactions between individual layers have long been known. However, these interactions are not weak enough to allow graphite to readily exfoliate into graphene on a large scale. Separating graphite layers down to a single sheet is an intense area of research as scientists attempt to utilize graphene's superlative properties. The exfoliation and processing of layered materials is governed by the friction between layers. Friction on the macroscale can be intuitively understood, but there is little understanding of the mechanisms involved in nanolayered materials...
February 13, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29435653/epidemiological-trends-in-spine-surgery-over-10%C3%A2-years-in-a-multicenter-database
#12
Kazuyoshi Kobayashi, Kei Ando, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
PURPOSE: There are few epidemiological studies of spinal surgery in Asia and none in Japan. The goal of this study was to review spine surgeries performed in our group between 2004 and 2015 in a cross-sectional study, with a focus on the effects of the superaging society on the characteristics and trends of spinal surgeries. METHODS: A retrospective review was performed for all 45,831 spinal surgeries conducted between 2004 and 2015 and recorded in our prospective multicenter database...
February 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29434517/bifurcation-of-elastic-solids-with-sliding-interfaces
#13
D Bigoni, N Bordignon, A Piccolroaz, S Stupkiewicz
Lubricated sliding contact between soft solids is an interesting topic in biomechanics and for the design of small-scale engineering devices. As a model of this mechanical set-up, two elastic nonlinear solids are considered jointed through a frictionless and bilateral surface, so that continuity of the normal component of the Cauchy traction holds across the surface, but the tangential component is null. Moreover, the displacement can develop only in a way that the bodies in contact do neither detach, nor overlap...
January 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29431385/glucose-management-in-hospitalized-patients
#14
Charles Kodner, Laurie Anderson, Katherine Pohlgeers
Glucose management in hospitalized patients poses challenges to physicians, including identifying blood glucose targets, judicious use of oral diabetes mellitus medications, and implementing appropriate insulin regimens. Uncontrolled blood glucose levels can lead to deleterious effects on wound healing, increased risk of infection, and delays in surgical procedures or discharge from the hospital. Previously recommended strict blood glucose targets for hospitalized patients result in more cases of hypoglycemia without improvement in patient outcomes...
November 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/29417324/radiological-severity-of-hip-osteoarthritis-in-patients-with-adult-spinal-deformity-the-effect-on-spinopelvic-and-lower-extremity-compensatory-mechanisms
#15
Louis M Day, Edward M DelSole, Bryan M Beaubrun, Peter L Zhou, John Y Moon, Jared C Tishelman, Jonathan M Vigdorchik, Ran Schwarzkopf, Renaud Lafage, Virginie Lafage, Themistocles Protopsaltis, Aaron J Buckland
PURPOSE: Sagittal spinal deformity (SSD) patients utilize pelvic tilt (PT) and their lower extremities in order to compensate for malalignment. This study examines the effect of hip osteoarthritis (OA) on compensatory mechanisms in SSD patients. METHODS: Patients ≥ 18 years with SSD were included for analysis. Spinopelvic, lower extremity, and cervical alignment were assessed on standing full-body stereoradiographs. Hip OA severity was graded by Kellgren-Lawrence scale (0-4)...
February 7, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29401420/cooperative-accumulation-of-dynein-dynactin-at-microtubule-minus-ends-drives-microtubule-network-reorganization
#16
Ruensern Tan, Peter J Foster, Daniel J Needleman, Richard J McKenney
Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin complexes drive MT-MT sliding, reorganization, and focusing, activities required for mitotic spindle assembly. We find that motors cooperatively accumulate, in limited numbers, at MT minus-ends. Minus-end accumulations drive MT-MT sliding, independent of MT orientation, resulting in the clustering of MT minus-ends...
January 22, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29396868/an-innovative-method-to-quantitate-tissue-integration-of-hyaluronic-acid-based-dermal-fillers
#17
A S Dugaret, B Bertino, B Gauthier, B Gamboa, M Motte, Y Rival, D Piwnica, H Osman-Ponchet, V Bourdès, J J Voegel
BACKGROUND/PURPOSE: Following intradermal injection, hyaluronic acid (HA)-based fillers tend to spread within the reticular dermis and to distribute between the dermal fibers. This biointegration is commonly measured qualitatively using histological methods. We developed a "toolbox" consisting of a visual scoring and a semi-automatic image analysis method using internal developed algorithm to quantitate the biointegration of Restylane® in histological sections. METHODS: Restylane® was injected intradermally in the abdominal skin of 10 healthy human subjects scheduled for abdominoplasty...
February 2, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29391731/comparitive-efficacies-of-a-natural-fixative-with-a-conventional-fixative
#18
Nidhi Sinha, Meghanand T Nayak, J D Sunitha, Geetanshu Dawar, Neelakshi Rallan, Shreya Gupta
Introduction: The quest for formalin substitutes has long been going on due to its health hazards. Honey has been recognized as a safe substitute for formalin. However, we explored jaggery as a natural substitute for formalin. The aim of this study was to compare the tissue fixation abilities of jaggery syrup (30%) with that of 10% neutral-buffered formalin (NBF) and to determine the best fixative among both. Materials and Methods: A study was conducted with 65 pathological tissues...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29390806/theoretical-restrictions-on-longest-implicit-time-scales-in-markov-state-models-of-biomolecular-dynamics
#19
Anton V Sinitskiy, Vijay S Pande
Markov state models (MSMs) have been widely used to analyze computer simulations of various biomolecular systems. They can capture conformational transitions much slower than an average or maximal length of a single molecular dynamics (MD) trajectory from the set of trajectories used to build the MSM. A rule of thumb claiming that the slowest implicit time scale captured by an MSM should be comparable by the order of magnitude to the aggregate duration of all MD trajectories used to build this MSM has been known in the field...
January 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29388090/shaping-conservative-spinal-services-with-the-spine-tango-registry
#20
Samuel Morris, James Booth
PURPOSE: This study reports the results of a registry data collection project within a secondary care spinal osteopathy service. METHODS: Clinical and demographic data were collected using the Spine Tango Conservative registry data collection tool. Outcomes were assessed using the Numerical Pain Rating Scale (NPRS), Oswestry Disability Index (ODI), Neck Disability Index (NDI), COMI Low Back Conservative (COMI-LBC), COMI Neck Conservative (COMI-NC) and EQ5D. Global treatment outcome (GTO), satisfaction with care and therapeutic complications were reported using the Spine Tango Patient Self Assessment form (STPSA)...
January 31, 2018: European Spine Journal
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