keyword
https://read.qxmd.com/read/38200149/sibp-03-a-novel-anti-her3-antibody-exerts-antitumor-effects-and-synergizes-with-egfr-and-her2-targeted-drugs
#21
JOURNAL ARTICLE
Wen-Jing Li, Cheng-Ying Xie, Xi Zhu, Jiao Tang, Lei Wang, Li-Guang Lou
HER3 (human epidermal growth factor receptor 3) acts through heterodimerization with EGFR (epidermal growth factor receptor) or HER2 to play an essential role in activating phosphoinositide 3-kinase (PI3K) and AKT signaling-a crucial pathway that promotes tumor cell survival. HER3 is a promising target for cancer therapy, and several HER3-directed antibodies have already entered into clinical trials. In this study we characterized a novel anti-HER3 monoclonal antibody, SIBP-03. SIBP-03 (0.01-10 μg/mL) specifically and concentration-dependently blocked both neuregulin (NRG)-dependent and -independent HER3 activation, attenuated HER3-mediated downstream signaling and inhibited cell proliferation...
January 10, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38186791/study-of-neuregulin-4-levels-in-newly-diagnosed-type-2-diabetes-mellitus
#22
JOURNAL ARTICLE
D Akshay, Ajay Chauhan, Parul Goyal, V Pranesh
BACKGROUND: Neuregulin-4 is a recently recognized adipokine acting as ligands to tyrosine kinases receptor of the Erb B family. This adipose tissue augmented endocrine factor participates in the modulation of lipid and glucose metabolism and energy homeostasis. This novel adipokine is associated with insulin resistance, dyslipidemia, obesity, oxidative stress, and inflammation. OBJECTIVE: The study aimed to compare plasma levels of neuregulin-4 in newly diagnosed type 2 diabetes mellitus as compared to matched controls and to correlate with glycemic and lipid parameters...
November 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38175774/adipocyte-precursor-derived-nrg1-promotes-resistance-to-fgfr-inhibition-in-urothelial-carcinoma
#23
JOURNAL ARTICLE
Sana Hosni, Viola Kilian, Niklas Klümper, Daniela Gabbia, Katharina Sieckmann, Dillon Corvino, Anja Winkler, Miriam Saponaro, Karin Woersdoerfer, Doris Schmidt, Oliver Hahn, Ilaria Zanotto, Marina Bertlich, Marieta Toma, Tobias Bald, Markus Eckstein, Michael Hölzel, Matthias Geyer, Manuel Ritter, Dagmar Wachten, Sara De Martin, Abdullah Alajati
Aberrations of the fibroblast growth factor receptor (FGFR) family members are frequently observed in metastatic urothelial cancer (mUC), and blocking the FGF/FGFR signaling axis is used as a targeted therapeutic strategy for treating patients. Erdafitinib is a pan-FGFR inhibitor that has recently been approved by the Food and Drug Administration for mUC with FGFR2/3 alterations. Although mUC patients show initial response to erdafitinib, acquired resistance rapidly develops. Here, we found that adipocyte precursors promoted resistance to erdafitinib in FGFR-dependent bladder and lung cancer in a paracrine manner...
January 4, 2024: Cancer Research
https://read.qxmd.com/read/38164560/intranasal-delivery-of-ketamine-induces-cortical-disinhibition
#24
JOURNAL ARTICLE
Xin Qiao, Steven F Grieco, Zhaoxia Yu, Todd C Holmes, Xiangmin Xu
Our previous studies find that subcutaneously administered (s.c.) subanesthetic ketamine promotes sustained cortical disinhibition and plasticity in adult mouse binocular visual cortex (bV1). We hypothesized that intranasal delivery (i.n.) of subanesthetic ketamine may have similar actions. To test this, we delivered ketamine (10 mg/kg; i.n.) to adult mice, and then recorded excitatory pyramidal neurons or PV+ interneurons in L2/3 of bV1 slices. In pyramidal neurons the baseline IPSC amplitudes from mice treated with ketamine are significantly weaker than in control mice...
December 14, 2023: ENeuro
https://read.qxmd.com/read/38155836/extracellular-molecular-signals-shaping-dendrite-architecture-during-brain-development
#25
REVIEW
Mohammad I K Hamad, Bright Starling Emerald, Kukkala K Kumar, Marwa F Ibrahim, Bassam R Ali, Mo'ath F Bataineh
Proper growth and branching of dendrites are crucial for adequate central nervous system (CNS) functioning. The neuronal dendritic geometry determines the mode and quality of information processing. Any defects in dendrite development will disrupt neuronal circuit formation, affecting brain function. Besides cell-intrinsic programmes, extrinsic factors regulate various aspects of dendritic development. Among these extrinsic factors are extracellular molecular signals which can shape the dendrite architecture during early development...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38152071/effect-of-diet-low-in-advanced-glycation-end-products-on-appetite-body-composition-and-brown-adipose-tissue-markers-in-patients-with-coronary-artery-disease-treated-with-angioplasty-a-randomized-controlled-trial
#26
JOURNAL ARTICLE
Fatemeh Taheri, Ali Vasheghani-Farahani, Elaheh Honarkar-Shafie, Hamidreza Poorhosseini, Mehdi Yaseri, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND: Recent changes in dietary habits have resulted in increased intake of advanced glycation end products (AGEs), which are known to have a predominant contribution to the pathogenesis and complications of coronary artery disease (CAD). AGEs are also thought to induce weight gain by affecting appetite, energy expenditure, and brown adipose tissue (BAT). Here, we investigated whether the restriction of dietary AGEs could affect appetite, body composition, anthropometric indices, and BAT-derived markers in CAD patients treated with angioplasty...
2023: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/38146414/implications-of-the-serum-concentrations-of-neuregulin-4-nrg4-in-patients-with-coronary-artery-disease-a-case-control-study
#27
JOURNAL ARTICLE
Fatemeh Taheri, Mohammad Javad Hosseinzadeh-Attar, Elham Alipoor, Elaheh Honarkar-Shafie, Mehdi Yaseri, Ali Vasheghani-Farahani
BACKGROUND: Neuregulin-4 (Nrg4), a novel brown fat-enriched factor, has been reported to play a crucial role in developing metabolic disorders. The current case-control study aimed to investigate the association between serum Nrg4 and coronary artery disease (CAD). METHODS: This study enrolled 43 patients with CAD and 43 subjects with normal coronary arteries diagnosed by coronary angiography. Anthropometric and biochemical parameters were measured and recorded...
July 2023: Journal of Tehran Heart Center
https://read.qxmd.com/read/38136890/comparative-serum-proteome-profiling-of-canine-benign-prostatic-hyperplasia-before-and-after-castration
#28
JOURNAL ARTICLE
Sekkarin Ploypetch, Grisnarong Wongbandue, Sittiruk Roytrakul, Narumon Phaonakrop, Nawarus Prapaiwan
BPH is the most prevalent prostatic condition in aging dogs. Nevertheless, clinical diagnosis and management remain inconsistent. This study employed in-solution digestion coupled with nano-liquid chromatography tandem mass spectrometry to assess serum proteome profiling of dogs with BPH and those dogs after castration. Male dogs were divided into two groups; control and BPH groups. In the BPH group, each dog was evaluated at two time points: Day 0 (BF subgroup) and Day 30 after castration (AT subgroup). In the BF subgroup, three proteins were significantly upregulated and associated with dihydrotestosterone: solute carrier family 5 member 5, tyrosine-protein kinase, and FRAT regulator of WNT signaling pathway 1...
December 14, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38136627/a-novel-form-of-neuregulin-1-type-iii-caused-by-n-terminal-processing
#29
JOURNAL ARTICLE
Yukai Wang, Yu Zhang, Yingxing Wang, Hong Chen, Liangjing Pan, Xufeng Liao, Shunqi Wang
Nrg1 (Neuregulin 1) type III, a susceptible gene of schizophrenia, exhibits a critical role in the central nervous system and is essential at each stage of Schwann's cell development. Nrg1 type III comprises double-pass transmembrane domains, with the N-terminal and C-terminal localizing inside the cells. The N-terminal transmembrane helix partially overlaps with the cysteine-rich domain (CRD). In this study, Nrg1 type III constructs with different tags were transformed into cultured cells to verify whether CRD destroyed the transmembrane helix formation...
December 7, 2023: Biomolecules
https://read.qxmd.com/read/38136166/the-role-of-adipokines-and-myokines-in-the-pathogenesis-of-different-obesity-phenotypes-new-perspectives
#30
REVIEW
Marta Pelczyńska, Ewa Miller-Kasprzak, Marcin Piątkowski, Roksana Mazurek, Mateusz Klause, Anna Suchecka, Magdalena Bucoń, Paweł Bogdański
Obesity is a characteristic disease of the twenty-first century that is affecting an increasing percentage of society. Obesity expresses itself in different phenotypes: normal-weight obesity (NWO), metabolically obese normal-weight (MONW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). A range of pathophysiological mechanisms underlie the occurrence of obesity, including inflammation, oxidative stress, adipokine secretion, and other processes related to the pathophysiology of adipose tissue (AT)...
November 26, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38134557/anti-inflammatory-effects-of-neuregulin-1-in-hacat-keratinocytes-and-atopic-dermatitis-like-mice-stimulated-with-der-p-38
#31
JOURNAL ARTICLE
Jeong Hee Yun, Yujin Hong, Min Hwa Hong, Geunyeong Kim, Ji-Sook Lee, Ran-Sook Woo, Juram Lee, Eun Ju Yang, In Sik Kim
Neuregulin (NRG)-1 plays fundamental roles in several organ systems after binding to its receptors, ErbB2 and ErbB4. This study examines the role of NRG-1 in atopic dermatitis (AD), a chronic skin disease that causes dryness, pruritus, and inflammation. In mice administered Der p 38, the skin presents AD-like symptoms including filaggrin downregulation and infiltration of neutrophils and eosinophils. Noticeably, there is an increased expression of NRG-1, ErbB2, and ErbB4 in the skin. Upregulation of these proteins is significantly correlated to the clinical skin severity score...
February 2024: Cytokine
https://read.qxmd.com/read/38132478/nrg1-regulates-proliferation-migration-and-differentiation-of-human-limbal-epithelial-stem-cells
#32
JOURNAL ARTICLE
Bofeng Wang, Huizhen Guo, Zhuo Han, Siqi Wu, Jiafeng Liu, Zesong Lin, Fengjiao An, Jin Zhu, Mingsen Li
Limbal epithelial stem/progenitor cells (LESCs) proliferate, migrate and differentiate into mature corneal epithelium cells (CECs) that cover the ocular surface. LESCs play a crucial role in the maintenance and regeneration of the corneal epithelium, and their dysfunction can lead to various corneal diseases. Neuregulin 1 (NRG1) is a member of the epidermal growth factor family that regulates the growth and differentiation of epithelial tissues. Here, we depicted the dynamic transcriptomic profiles during human CEC differentiation, identifying six gene co-expression modules that were specific to different differentiation stages...
December 14, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/38114668/editorial-expression-of-concern-altered-neuregulin-1-erbb4-signaling-contributes-to-nmda-receptor-hypofunction-in-schizophrenia
#33
Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop, Steven E Arnold
No abstract text is available yet for this article.
December 19, 2023: Nature Medicine
https://read.qxmd.com/read/38111957/enos-plays-essential-roles-in-the-developing-heart-and-aorta-linked-to-disruption-of-notch-signalling
#34
JOURNAL ARTICLE
Lorraine Eley, Rachel V Richardson, Ahlam Alqahtani, Bill Chaudhry, Deborah J Henderson
eNOS (NOS3) is the enzyme that generates nitric oxide, a signalling molecule and regulator of vascular tone. Loss of eNOS function is associated with increased susceptibility to atherosclerosis, hypertension, thrombosis and stroke. Aortopathy and cardiac hypertrophy have also been found in eNOS null mice, but their aetiology is unclear. We evaluated eNOS nulls before and around birth for cardiac defects, revealing severe abnormalities in the ventricular myocardium and pharyngeal arch arteries. Moreover, baroreceptors in the aortic arch, which sense changes in blood pressure, were reduced...
December 19, 2023: Disease Models & Mechanisms
https://read.qxmd.com/read/38107476/exerkines-and-osteoarthritis
#35
REVIEW
Shuangshuo Jia, Ziyao Yu, Lunhao Bai
Osteoarthritis (OA) is the most prevalent chronic joint disease, with physical exercise being a widely endorsed strategy in its management guidelines. Exerkines, defined as cytokines secreted in response to acute and chronic exercise, function through endocrine, paracrine, and/or autocrine pathways. Various tissue-specific exerkines, encompassing exercise-induced myokines (muscle), cardiokines (heart), and adipokines (adipose tissue), have been linked to exercise therapy in OA. Exerkines are derived from these kines, but unlike them, only kines regulated by exercise can be called exerkines...
2023: Frontiers in Physiology
https://read.qxmd.com/read/38079473/pak2-is-necessary-for-myelination-in-the-peripheral-nervous-system
#36
JOURNAL ARTICLE
Bo Hu, Daniel Moiseev, Isabella Schena, Bulat Faezov, Roland Dunbrack, Chernoff Jonathan, Jun Li
Myelination enables electrical impulses to propagate on axons at the highest speed, encoding essential life functions. The Rho family GTPases, RAC1 and CDC42, have been shown to critically regulate Schwann cell myelination. P21-activated kinase 2 (PAK2) is an effector of RAC1/CDC42, but its specific role in myelination remains undetermined. We produced a Schwann cell-specific knockout mouse of Pak2 (scPak2-/-) to evaluate PAK2's role in myelination. Deletion of Pak2 specifically in mouse Schwann cells resulted in severe hypomyelination, slowed nerve conduction velocity, and behavior dysfunctions in the scPak2-/- peripheral nerve...
December 11, 2023: Brain
https://read.qxmd.com/read/38065627/serum-neuregulin-1-in-relation-to-ventricular-function-and-subclinical-atherosclerosis-in-type-2-diabetes-patients
#37
JOURNAL ARTICLE
Aya Saad Eldin, Olfat Fawzy, Eman Mahmoud, Ola H Abd Elaziz, Alshimaa Ezzat A Enayet, Emad Gamil Khidr
BACKGROUND AND AIMS: Neuregulin 1 (NRG-1) is one of the members of the epidermal growth factors proteins. The present study provides novel insights into the relationship between serum levels of NRG-1 and insulin resistance, subclinical atherosclerosis and cardiac dysfunction that occur in type 2 diabetes (T2D). METHODS: The study included 50 patients with T2D and 40 healthy age- and gender-matched controls. Serum NRG-1 was measured using ELISA. Glycemic parameters, lipid profile and insulin resistance were assessed...
December 2023: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/38057021/effects-of-oleoylethanolamide-supplementation-on-the-expression-of-lipid-metabolism-related-genes-and-serum-nrg4-levels-in-patients-with-non-alcoholic-fatty-liver-disease-a-randomized-controlled-trial
#38
RANDOMIZED CONTROLLED TRIAL
Helda Tutunchi, Mehrangiz Ebrahimi-Mameghani, Mohammad Javad Hosseinzadeh-Attar, Neda Roshanravan, Majid Mobasseri, Farzad Najafipour, Fatemeh Naeini, Sina Naghshi, Samira Asghari, Moloud Akbarzadeh, Hamid Soleimanzadeh, Alireza Ostadrahimi
BACKGROUND: This study investigated the effects of oleoylethanolamide (OEA) supplementation on the expression levels of SIRT1, AMPK, PGC-1α, PPAR-γ, CEBP-α and CEBP-β genes and serum neuregulin 4 (NRG4) levels in patients with non-alcoholic fatty liver diseases (NAFLD). METHODS: Sixty obese patients with NAFLD were equally allocated into either OEA or placebo group for 12 weeks. The mRNA expression levels of genes were determined using the reverse transcription polymerase chain reaction (RT-PCR) technique...
December 2023: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38029398/tyrosine-kinase-receptor-erbb4-in-advillin-positive-neurons-contributes-to-inflammatory-pain-hypersensitivity-in-mouse-drg
#39
JOURNAL ARTICLE
Zhongxin Guo, Qingyun Huang, Wei Zhang, Kaiyue Shi, Jie Yuan, Shuya Qi, Bingyan Wang, Kuotao Li, Shuntang Li, Jiangu Gong, Xuechao Jing, Yuanyuan Liu, Guohe Tan
Inflammatory pain is a common type of pathological pain. Although the dorsal root ganglion (DRG) is key to pathogenesis of inflammatory pain, the underlying specific molecular and cellular mechanisms remain unclear. In this study, we used mouse models of acute or chronic inflammatory pain, induced by formalin or complete Freund' s adjuvant (CFA), respectively, to explore whether tyrosine kinase receptor ErbB4 participates in the pathogenesis of inflammatory pain. Firstly, we found that both the expression of Neuregulin 1 (Nrg1) and phosphorylation of ErbB4 receptor were upregulated in DRG after inflammatory pain, implying the activation of ErbB4 in DRG...
November 19, 2023: Aging and Disease
https://read.qxmd.com/read/38015639/neuregulin-4-mediates-the-metabolic-benefits-of-mild-cold-exposure-by-promoting-beige-fat-thermogenesis
#40
JOURNAL ARTICLE
Zhimin Chen, Peng Zhang, Tongyu Liu, Xiaoxue Qiu, Siming Li, Jiandie D Lin
Interorgan crosstalk via secreted hormones and metabolites is a fundamental aspect of mammalian metabolic physiology. Beyond the highly specialized endocrine cells, peripheral tissues are emerging as an important source of metabolic hormones that influence energy and nutrient metabolism and contribute to disease pathogenesis. Neuregulin 4 (Nrg4) is a fat-derived hormone that protects mice from nonalcoholic steatohepatitis (NASH) and NASH-associated liver cancer by shaping hepatic lipid metabolism and the liver immune microenvironment...
November 28, 2023: JCI Insight
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