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Liqin Liu, Yan Luo, Ruirui Zhang, Jianyou Guo
Gingseng is commonly used in traditional Chinese medicine community for the treatment of depression-like disorders. Ginsenosides is considered to be the major active components of ginseng. Previous studies have demonstrated that ginsenosides produced antidepressant-like action in various mouse models of behavioral despair. The present study aimed to examine whether ginsenosides could affect the chronic unpredictable mild stress (CUMS)-induced depression in rats. The mechanism(s) underlying the antidepressant-like action was investigated by measuring serum corticosterone level, glucocorticoid receptor (GR), mineralocorticoid receptor (MR) and brain-derived neurotrophic factor (BDNF) mRNA levels in brain tissues...
May 2011: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Jeongson Kim
Dietary factors are regarded as exerting major influences on cancer development in various organ sites and in Asia there is particular interest in the potential preventive effects of foodstuffs such as soy products and gingseng. The so-called phytoestrogens, like genistein and daidzein in soy, can bind to estrogen receptors and therefore interfere with the action of estrogen itself, a well-established risk factor for breast, ovarian and endometrial cancers. Although not all results are consistent, there is good evidence for protective influence of soy products against all three of these cancers...
October 2008: Asian Pacific Journal of Cancer Prevention: APJCP
Wenfei He, Gang Liu, Xin Chen, Jincai Lu, Hidehiro Abe, Kexin Huang, Masanobu Manabe, Hiroyuki Kodama
The effects of five ginsenosides (G-Rh2, -Rd, -Rb1, -Rb2, -Rh1) isolated from the root of Panax gingseng on stimulus-induced superoxide generation in human neutrophils were evaluated by measuring the reduction of ferricytochrome c. The tyrosyl or serine/threonine phosphorylation of neutrophil proteins and translocation of p47phox, p67phox, and Rac to the plasma membrane were detected using specific monoclonal antibodies. G-Rh2 significantly suppressed superoxide generation induced by N-formylmethionyl-leucylphenylalanine (fMLP), phorbol 12-myristate 13-acetate (PMA), and arachidonic acid (AA) in a concentration-dependent manner...
March 26, 2008: Journal of Agricultural and Food Chemistry
Serena Chan, Mei-Fong Kong, Yiu-Chung Wong, Siu-Kay Wong, Della W M Sin
A highly accurate and precise method based on isotope dilution gas chromatography-mass spectrometry was developed for the determination of five matrix-bound organochlorine pesticides, namely, hexachlorobenzene and hexachlorocyclohexanes (alpha-, beta-, delta-, and gamma- isomers), in a reference sample of Panax gingseng. Identification of the analytes was confirmed under selective ion monitoring mode by the presence of two dominant ion fragments within the specific time windows (+/-1% of the relative retention time with respect to the calibration standards) and matching of relative ion intensities of the concerned ions in samples and calibration standards (within +/-5%)...
May 2, 2007: Journal of Agricultural and Food Chemistry
Yu-guang Wang, Yue Gao, Biao-xin Chai, Peng Chen, Hong-ling Tan, Yong-hong Zhao, Cheng-rong Xiao, Yuan-yuan Sun, Li-jun Zhu
OBJECTIVE: To study the modulatory effect of Panax gingseng and coadministration with Veratrum nigrum on the activity and mRNA expression of cytochrome P450 isoenzymes in rat liver. METHOD: Rat liver microsomal cytochrome P450, b5, aminopyrine N-demethylase(APND), p-nitrophenol-hydroxylase(pNPH)activities were quantitated by UV chromatography. The mRNA expression level of five CYP isoenzymes CYP1A1, CYP2B1/2, CYP2C11, CYP2E1 and CYP3A1 were detected by semi-quantitative reverse transcriptase-polymerase chain reaction(RT-PCR)...
April 2004: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
J Wang, J Yang, J Chan, J Huang
The effect of Lopanthus roots extract on the HI humoral immunity and cell-mediated immunity in rat was investigated in this study. The result showed that the Lophanthus roots extract could enhance liver index in rat. By Lophanthus roots extract at the dosage of 2.50 g/kg in rat, the Immunoglobulin G(IgG), immunoglobulin A(IgA) and immunoglobulin M (IgM) were increased, C3 complenment exhanced and have a highly signifcance compared to the cation by the gingseng veinforce pill (P < 0.01). The Lophanthus roots extract could mildly increased effect of rosette formation and lymphocyte transformation, but no statistic sighnificance was found...
September 1997: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
E Tachikawa, K Kudo, T Kashimoto, E Takahashi
We investigated the effects of root of Panax ginseng C. A. Meyer on the secretion of catecholamines (CAs) from bovine adrenal chromaffin cells stimulated by acetylcholine (ACh). In two major parts, nonsaponin and crude saponin fractions from the root, the crude saponin but not the non-saponin greatly reduced the ACh-evoked secretion. Furthermore, various purified ginseng saponins (ginsenosides) had a tendency to reduce the secretion. Most effective saponin was ginsenoside (G) RG2. GRg2 also inhibited the ACh-evoked Na+ and Ca2+ influxes into the cells...
October 1997: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
H J Engels, J C Wirth
OBJECTIVE: To assess the effects of chronic supplementation with two different dosages of Panax ginseng C.A. Meyer on physiologic and psychological responses during graded maximal aerobic exercise. DESIGN: Randomized, double-blind, placebo-controlled trial. SUBJECTS: Thirty-six healthy men consuming an otherwise supplement-free diet who maintained their usual activity level. INTERVENTION: A standardized P ginseng C.A...
October 1997: Journal of the American Dietetic Association
E B Shentsova, M M Anisimov, Iu N Loenko, L N Atopkina, N F Samoshina, N I Uvarova
The effect of triterpene glycosides synthesized on the basis of betulafolientriol, ginsenoside Rb1 from gingseng, betulafolientriol and its 3-epimer on the growth of the Ehrlich tumor cell cultures was studied. It was shown that, in relation to the quantitative composition and sites of carbohydrate residue linkage to aglycone as well as configuration of the alpha- or beta-hydroxyl group at C-3, the activity of the triterpenoids of the dammaranic series changed within wide ranges. 3- and 12-0-beta-D-glycosides of 3-epibetulafolientriol proved to be the most active...
November 1989: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
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