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https://www.readbyqxmd.com/read/27754187/sp-04-2-lcz-696-a-new-paradigm-shift-for-the-treatment-of-heart-failure
#1
ByungSu Yoo
Heart failure (HF) represents a significant healthcare issue because of its ever-increasing prevalence, poor prognosis and complex pathophysiology. The cornerstone of modern drug therapy in chronic HF is the inhibition of neurohormonal activation that plays a crucial role in the pathophysiology of HF development and progression and, more specifically, of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. LCZ696 is a first-in-class, angiotensin receptor NEP inhibitor (ARNI) that consists of a supramolecular complex of a molecule of the ARB valsartan in combination with a molecule of the NEP inhibitor prodrug AHU377 (also known as sacubitril)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643144/sp-04-2-lcz-696-a-new-paradigm-shift-for-the-treatment-of-heart-failure
#2
ByungSu Yoo
Heart failure (HF) represents a significant healthcare issue because of its ever-increasing prevalence, poor prognosis and complex pathophysiology. The cornerstone of modern drug therapy in chronic HF is the inhibition of neurohormonal activation that plays a crucial role in the pathophysiology of HF development and progression and, more specifically, of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. LCZ696 is a first-in-class, angiotensin receptor NEP inhibitor (ARNI) that consists of a supramolecular complex of a molecule of the ARB valsartan in combination with a molecule of the NEP inhibitor prodrug AHU377 (also known as sacubitril)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27323760/depth-of-anaesthesia-assessment-based-on-adult-electroencephalograph-beta-frequency-band
#3
Tianning Li, Peng Wen
This paper presents a new method to apply timing characteristics of electroencephalograph (EEG) beta frequency bands to assess the depth of anaesthesia (DoA). Firstly, the measured EEG signals are denoised and decomposed into 20 different frequency bands. The Mobility (M), permutation entropy (PE) and Lempel-Ziv complexity (LCZ) of each frequency band are calculated. The M, PE and LCZ values of beta frequency bands (21.5-30 Hz) are selected to derive a new index. The new index is evaluated and compared with measured bispectral (BIS)...
September 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/26075858/-inhibition-of-renin-angiotensin-aldosterone-system-in-heart-failure-or%C3%A2-from-consensus-to-paradigm-hf
#4
REVIEW
Jiří Vítovec, Jindřich Špinar, Lenka Špinarová
An historical survey is presented of mortality trials on angiotensin-aldosteron system inhibition in patients with chronic heart failure. From the CONSENSUS trial up to the PARADIGM-HF trial, ACE inhibitors/angiotensin II receptor antagonists (AT1-blockers, ARBs, sartans), along with mineralocorticoid receptor blockers, have been the gold standard of treatment. Both direct renin blocker aliskiren and dual blocker enalapril + neprilysin proved ineffective; on the other hand, the new dual inhibitor valsartan + neprilysin LCZ 696 is a new and promising therapeutic agent for future treatment of chronic heart failure...
May 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26022006/effect-of-the-angiotensin-receptor-neprilysin-inhibitor-lcz696-compared-with-enalapril-on-mode-of-death-in-heart-failure-patients
#5
RANDOMIZED CONTROLLED TRIAL
Akshay S Desai, John J V McMurray, Milton Packer, Karl Swedberg, Jean L Rouleau, Fabian Chen, Jianjian Gong, Adel R Rizkala, Abdel Brahimi, Brian Claggett, Peter V Finn, Loren Howard Hartley, Jiankang Liu, Martin Lefkowitz, Victor Shi, Michael R Zile, Scott D Solomon
AIMS: The angiotensin-receptor-neprilysin inhibitor (ARNI) LCZ696 reduced cardiovascular deaths and all-cause mortality compared with enalapril in patients with chronic heart failure in the prospective comparison of ARNI with an Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. To more completely understand the components of this mortality benefit, we examined the effect of LCZ696 on mode of death. METHODS AND RESULTS: PARADIGM-HF was a prospective, double-blind, randomized trial in 8399 patients with chronic heart failure, New York Heart Association Class II-IV symptoms, and left ventricular ejection fraction ≤40% receiving guideline-recommended medical therapy and followed for a median of 27 months...
August 7, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25748486/prediction-of-adherent-placenta-in-pregnancy-with-placenta-previa-using-ultrasonography-and-magnetic-resonance-imaging
#6
Kenji Tanimura, Yui Yamasaki, Yasuhiko Ebina, Masashi Deguchi, Yoshiko Ueno, Kazuhiro Kitajima, Hideto Yamada
OBJECTIVE: Adherent placenta is a life-threatening condition in pregnancy, and is often complicated by placenta previa. The aim of this prospective study was to determine prenatal imaging findings that predict the presence of adherent placenta in pregnancies with placenta previa. STUDY DESIGN: The study included 58 consecutive pregnant women with placenta previa who underwent both ultrasonography and magnetic resonance imaging prenatally. Ultrasonographic findings of anterior placental location, grade 2 or higher placental lacunae (PL≥G2), loss of retroplacental hypoechoic clear zone (LCZ) and the presence of turbulent blood flow in the arteries were evaluated, in addition to MRI findings...
April 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/25675966/anti-inflammatory-activity-of-lanoconazole-a-topical-antifungal-agent
#7
Hideya Uratsuji, Aki Nakamura, Yoshihito Yamada, Kei Hashimoto, Tatsumi Matsumoto, Fumiaki Ikeda, Ritsuko Ishii
Topical antifungal agents which have anti-inflammatory effects have the potential to provide additional clinical benefits. Therefore, an anti-inflammatory activity of lanoconazole (LCZ), a topical antifungal agent, was investigated against in vitro and in vivo models of inflammation. The release of interleukin-8 (IL-8) from human epidermal keratinocytes stimulated by the addition of 100 μg ml(-1) β-glucan of Saccharomyces cerevisiae was significantly inhibited by LCZ at the concentration of 10(-5) mol l(-1)...
April 2015: Mycoses
https://www.readbyqxmd.com/read/24854958/a-pilot-study-on-the-effect-of-lactobacillus-casei-zhang-on-intestinal-microbiota-parameters-in-chinese-subjects-of-different-age
#8
L Y Kwok, L Wang, J Zhang, Z Guo, H Zhang
Ageing of the population is an imminent global problem. Lactobacillus casei Zhang (LcZ) was isolated from Inner Mongolian fermented milk, koumiss. LcZ possesses numerous probiotic properties in in vitro tests and in animal models. However, it has never been tested in any human trial. In the current study, the impact of oral consumption of LcZ on different age groups was tested. Chinese subjects, including 10 young, 7 middle-aged and 7 elderly volunteers (with mean age of 24.3, 47.6 and 64.7, respectively), were recruited...
September 2014: Beneficial Microbes
https://www.readbyqxmd.com/read/24702028/454-pyrosequencing-reveals-changes-in-the-faecal-microbiota-of-adults-consuming-lactobacillus-casei-zhang
#9
Jiachao Zhang, Lifeng Wang, Zhuang Guo, Zhihong Sun, Qimu Gesudu, Laiyu Kwok, Menghebilige, Heping Zhang
Probiotics are believed to help to maintain a healthy balance of the human gut microbiota. Lactobacillus casei Zhang (LcZ) is a novel potential probiotic isolated from the naturally fermented food koumiss. To better understand the impact of this potential probiotic on human intestinal microbiota, 24 subjects were randomly recruited for a longitudinal study: the subjects were required to consume LcZ for 28 days, and faecal samples were collected prior to, during and after the LcZ consumption phase. Alterations in the gut microbiota were monitored using 454 pyrosequencing and quantitative polymerase chain reaction(q-PCR) technologies...
June 2014: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/23350674/lactobacillus-casei-zhang-modulate-cytokine-and-toll-like-receptor-expression-and-beneficially-regulate-poly-i-c-induced-immune-responses-in-raw264-7-macrophages
#10
Yuzhen Wang, Jiming Xie, Na Wang, Yunxu Li, Xiaolin Sun, Yong Zhang, Heping Zhang
Lactobacilli are frequently used as probiotics due to their beneficial effects on health. Lactobacillus casei Zhang (LcZ), which has favorable probiotic properties, was first isolated from koumiss. In this study, the immunomodulating effects of LcZ on cytokine and toll-like receptor expression in RAW264.7 macrophages was assessed and it was found that live LcZ promotes production of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and interferon (IFN)-β. Transcription of inducible nitric oxide synthase (iNOS) was also enhanced by viable LcZ...
January 2013: Microbiology and Immunology
https://www.readbyqxmd.com/read/23171162/restoration-of-endodontically-treated-teeth-with-major-hard-tissue-loss-bond-strength-of-conventionally-and-adhesively-luted-fiber-reinforced-composite-posts
#11
Stefanie Binus, Andreas Koch, Anselm Petschelt, Christine Berthold
AIM: To evaluate the influence of the luting system on the pull-out bond strength of conventionally and adhesively luted fiber-reinforced composite posts (FRCPs). MATERIAL AND METHODS: One hundred extracted bovine teeth (Di 3) were endodontically treated and randomly assigned to nine test groups and one control group (n = 10) according to luting system. After preparing the post cavities (8 mm), the custom-made FRCPs were inserted using conventional glass-ionomer cement (Ketac Cem), resin-reinforced glass-ionomer cement (Meron Plus and Fuji Plus), self-adhesive resin cement (RelyX Unicem and BisCem), self-conditioning adhesive and resin cement [Multilink Primer + Multilink and AdheSE + DC Activator + MultiCore Flow, or etch-and-rinse adhesive and resin cement (SealBond Ultima + CoreCem, and LuxaBond + LuxaCore Z)...
October 2013: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/23146349/protective-effects-of-probiotic-lactobacillus-casei-zhang-against-endotoxin-and-d-galactosamine-induced-liver-injury-in-rats-via-anti-oxidative-and-anti-inflammatory-capacities
#12
Yuzhen Wang, Yunxu Li, Jiming Xie, Yong Zhang, Jinling Wang, Xiaolin Sun, Heping Zhang
Lactobacillus casei Zhang (LcZ) has been recently isolated from the traditional Mongolian beverage koumiss and has a set of favorable probiotic properties, including aciduricity, bile resistance and ability to colonize the gastrointestinal tract. We have previously reported the anti-oxidative properties of LcZ in the hyperlipidemic rats. In this study, the hepatoprotective effects of LcZ against lipopolysaccharide (LPS) and d-galactosamine (D-GalN)-induced liver injury were investigated. We found that pretreatment with LcZ significantly improved survival of rats challenged with LPS/D-GalN...
January 2013: International Immunopharmacology
https://www.readbyqxmd.com/read/23062198/lactobacillus-casei-zhang-modulate-cytokine-and-toll-like-receptor-expression-and-beneficially-regulate-polyi-c-induced-immune-responses-in-raw264-7-macrophages
#13
Yuzhen Wang, Jiming Xie, Na Wang, Yunxu Li, Xiaolin Sun, Yong Zhang, Heping Zhang
Lactobacilli are frequently used as probiotics due to their health-benefiting effects. Lactobacillus casei Zhang (LcZ), exhibiting favorite probiotic properties, was isolated from koumiss. In this study, we assessed the immunomodulating effects of LcZ on cytokine and toll-like receptor expression in RAW264.7 macrophages. Our results showed that live LcZ promoted the production of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and interferon (IFN)-β. The transcription of inducible nitric oxide synthase (iNOS) was also enhanced by viable LcZ...
October 15, 2012: Microbiology and Immunology
https://www.readbyqxmd.com/read/22994500/diuretics-aggravate-zinc-deficiency-in-patients-with-liver-cirrhosis-by-increasing-zinc-excretion-in-urine
#14
Miho Chiba, Kazuhiro Katayama, Risato Takeda, Rie Morita, Kiyoshi Iwahashi, Yoshiki Onishi, Hisaaki Kita, Akira Nishio, Tomoyo Kanno, Tamiko Saito, Kosaku Maeda, Masafumi Naito, Tomoki Michida, Toshifumi Ito
AIM: Liver cirrhosis is often accompanied by zinc deficiency. The exact mechanisms underlying zinc deficiency remain unclear. This study was undertaken to clarify the influence of diuretics on blood zinc levels and zinc excretion in urine in liver cirrhosis. METHODS: Seventy-nine outpatients with liver cirrhosis were divided into four groups: (i) patients receiving no zinc preparations or diuretics (LC group); (ii) those receiving zinc preparations only (LCZ group); (iii) those receiving diuretics only (LCD group); and (iv) those receiving both zinc preparations and diuretics (LCDZ group)...
April 2013: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/22020787/effects-of-acupuncture-and-moxibustion-in-a-mouse-model-of-allergic-rhinitis
#15
COMPARATIVE STUDY
Dallim Jung, Seungdeok Lee, Seungug Hong
OBJECTIVE: In this study, the authors examined the effects of acupuncture and moxibustion on the expression of various inflammatory cells and mediators in the nasal mucosa of an allergic rhinitis (AR) animal model. STUDY DESIGN: Randomized controlled animal study. SETTING: Animal laboratory in a Dongguk University. SUBJECTS AND METHODS: Twenty-eight BALB/c mice were divided into 4 groups: control, levocetirizine (Lcz), moxibustion (Mox), and acupuncture (Acu)...
January 2012: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/20489139/myeloid-cd34-cd13-precursor-cells-transdifferentiate-into-chondrocyte-like-cells-in-atherosclerotic-intimal-calcification
#16
Lars Christian Doehring, Christian Heeger, Zouhair Aherrahrou, Piotr Maciel Kaczmarek, Jeanette Erdmann, Heribert Schunkert, Eva-Maria Ehlers
Chondrogenic differentiation is pivotal in the active regulation of artery calcification. We investigated the cellular origin of chondrocyte-like cells in atherosclerotic intimal calcification of C57BL/6 LDLr(-/-) mice using bone marrow transplantation to trace ROSA26-LacZ-labeled cells. Immunohistochemical costaining of collagen type II with LacZ and leukocyte defining surface antigens was performed and analyzed by high-resolution confocal microscopy. Chondrocyte-like cells were detected in medium and advanced atherosclerotic plaques accounting for 7...
July 2010: American Journal of Pathology
https://www.readbyqxmd.com/read/19808127/levocetirizine-for-the-treatment-of-allergic-rhinitis-and-chronic-idiopathic-urticaria-in-adults-and-children
#17
REVIEW
Devada Singh-Franco, Hoytin Lee Ghin, Gisela I Robles, Nancy Borja-Hart, Alexandra Perez
BACKGROUND: Levocetirizine (LCZ) is a second-generation antihistamine that was approved in January 2008 for the relief of symptoms of seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR), and chronic idiopathic urticaria (CIU) in adults and children aged > or = 6 years. OBJECTIVES: This article reviews the available literature on the pharmacokinetics and pharmacodynamics, clinical efficacy and tolerability, and effect on quality of life (QoL) of LCZ...
August 2009: Clinical Therapeutics
https://www.readbyqxmd.com/read/18293707/-visual-evoked-potentials-in-the-in-evaluation-of-the-safety-profile-of-levocetirizine
#18
Florica Popescu, F D Popescu, Maria Iancău, D Georgescu
UNLABELLED: Because human histamine H1 receptors were visualized at different brain levels, we evaluated the effects of levocetirizine (LCZ) on the visual evoked potentials (VEP). MATERIAL AND METHOD: Eighteen volunteer subjects were included in a placebo-controlled study, VEP recordings (pattern-reversal technique) were performed at baseline and 240 min. post-medication, and the N75-P100-N135 complex parameters (latency, duration, amplitude and surface of the components) were measured in the leads FzOL5, FzOz and FzOR5...
July 2007: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/17628043/surface-analysis-under-ambient-conditions-using-plasma-assisted-desorption-ionization-mass-spectrometry
#19
Lucy V Ratcliffe, Frank J M Rutten, David A Barrett, Terry Whitmore, David Seymour, Claire Greenwood, Yolanda Aranda-Gonzalvo, Steven Robinson, Martin McCoustra
A novel plasma-assisted desorption/ionization (PADI) method that can be coupled with atmospheric pressure sampling mass spectrometry to yield mass spectral information under ambient conditions of pressure and humidity from a range of surfaces without the requirement for sample preparation or additives is reported. PADI is carried out by generating a nonthermal plasma which interacts directly with the surface of the analyte. Desorption and ionization then occur at the surface, and ions are sampled by the mass spectrometer...
August 15, 2007: Analytical Chemistry
https://www.readbyqxmd.com/read/16961716/levocetirizine-in-persistent-allergic-rhinitis-and-asthma-effects-on-symptoms-quality-of-life-and-inflammatory-parameters
#20
RANDOMIZED CONTROLLED TRIAL
M Pasquali, I Baiardini, A Rogkakou, A M Riccio, C Gamalero, D Descalzi, C Folli, G Passalacqua, G W Canonica
Background Levocetirizine (LCZ) has been shown to be effective in allergic rhinitis. We evaluated its clinical efficacy, antinflammatory actions and its effects on quality of life (QoL) with a specific instrument in the asthma-rhinitis comorbidity. Methods Fifty adult patients with persistent rhinitis with/without asthma were enrolled. After a 1-week run-in for baseline evaluation, they were randomized to LCZ or placebo for 8 weeks. Cromolyn and salbutamol were permitted on demand. Rhinoconjunctivitis and asthma symptoms were evaluated by diary cards...
September 2006: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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