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https://www.readbyqxmd.com/read/29331603/metabolic-risk-factors-in-schizophrenia-and-bipolar-disorder-the-effect-of-comedication-with-selective-serotonin-reuptake-inhibitors-and-antipsychotics
#1
K K Fjukstad, A Engum, S Lydersen, I Dieset, N Eiel Steen, O A Andreassen, O Spigset
BACKGROUND: The aim of this observational study was to investigate the relationship between metabolic factors and use of selective serotonin reuptake inhibitors (SSRIs) combined with olanzapine, quetiapine or risperidone. METHODS: Data from the Norwegian Thematically Organized Psychosis study, a cross-sectional study on 1301 patients with schizophrenia (n=868) or bipolar disorder (n=433), were analyzed. As exposure variables in the linear regression model were included the dose or serum concentration of SSRIs (n=280) and of olanzapine (n=398), quetiapine (n=234) or risperidone (n=128)...
April 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29326295/randomised-controlled-trial-of-escitalopram-for-cervical-dystonia-with-dystonic-jerks-tremor
#2
Evelien Zoons, Jan Booij, Catherine C S Delnooz, Joke M Dijk, Yasmine E M Dreissen, Johannes H T M Koelman, Sandra M A van der Salm, Matej Skorvanek, Marenka Smit, Majid Aramideh, Henriette Bienfait, Agnita J W Boon, Jeroen W M Brans, Edo Hoogerwaard, Ad Hovestadt, Daan J Kamphuis, Alexander G Munts, Johannes D Speelman, Marina A J Tijssen
OBJECTIVE: Trials for additional or alternative treatments for cervical dystonia (CD) are scarce since the introduction of botulinum neurotoxin (BoNT). We performed the first trial to investigate whether dystonic jerks/tremor in patients with CD respond to the selective serotonin reuptake inhibitor (SSRI) escitalopram. METHODS: In a randomised, double-blind, crossover trial, patients with CD received escitalopram and placebo for 6 weeks. Treatment with BoNT was continued, and scores on rating scales regarding dystonia, psychiatric symptoms and quality of life (QoL) were compared...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29302568/severe-hyponatremia-associated-with-escitalopram
#3
Gautam Rawal, Raj Kumar, Sankalp Yadav
Hyponatremia is a rare but potentially fatal complication of selective serotonin reuptake inhibitor (SSRI) therapy with only limited cases of escitalopram as the causative drug. We report the case of a 54-year-old hypertensive female who was admitted to the hospital with seizure episode and subsequently diagnosed to have severe hyponatremia due to SSRI-induced syndrome of inappropriate antidiuretic hormone (SIADH) with the cause attributed to the short history of intake of escitalopram for depression. All SSRIs, including escitalopram, can cause SIADH and should be used with caution in the depressive patients with regular monitoring of electrolytes, especially in the elderly...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29300091/what-contributes-to-snris-dual-targeting-mechanism-the-key-role-of-tm6-domain-in-hsert-and-hnet-revealed-by-molecular-dynamics-simulation
#4
Weiwei Xue, Fengyuan Yang, Panpan Wang, Guoxun Zheng, Yuzong Chen, Xiaojun Yao, Feng Zhu
Dual inhibition of serotonin and norepinephrine transporters (hSERT and hNET) gives greatly improved efficacy and tolerability for treating major depressive disorder (MDD) comparing with selective reuptake inhibitors. Pioneer studies provided valuable information of structure, function, and pharmacology of drugs dual-targeting hSERT and hNET (SNRIs), and the differential binding mechanism between SNRIs and selective inhibitors of 5-HT (SSRIs) / NE (sNRIs) to their corresponding target was expected to be able to facilitate the discovery of privileged drug-like scaffold with improved efficacy...
January 4, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29296032/escitalopram-induced-siadh-in-an-elderly-female-a-case-study
#5
Sudha Vidyasagar, Karthik Rao, Muralidhar Verma, Aswini Dutt Tripuraneni, Navin Patil, Dipanjan Bhattacharjee
Hyponatraemia is a well-established and potentially, a life-threatening adverse effect of selective serotonin receptor uptake inhibitors (SSRI). However, its occurrence secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with escitalopram, has been reported extremely sporadically. The reporting of such rare, but life-threatening adverse effects of escitalopram assumes immense significance in light of the fact that SSRIs presently form the mainstay of treatment of depressive disorders...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29288686/increased-amygdala-responses-to-emotional-faces-after-psilocybin-for-treatment-resistant-depression
#6
REVIEW
Leor Roseman, Lysia Demetriou, Matthew B Wall, David J Nutt, Robin L Carhart-Harris
Recent evidence indicates that psilocybin with psychological support may be effective for treating depression. Some studies have found that patients with depression show heightened amygdala responses to fearful faces and there is reliable evidence that treatment with SSRIs attenuates amygdala responses (Ma, 2015). We hypothesised that amygdala responses to emotional faces would be altered post-treatment with psilocybin. In this open-label study, 20 individuals diagnosed with moderate to severe, treatment-resistant depression, underwent two separate dosing sessions with psilocybin...
December 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29283680/effects-of-selective-serotonin-reuptake-inhibitors-on-macular-ganglion-cell-complex-thickness-and-peripapillary-retinal-nerve-fiber-layer-thickness
#7
Hande Guclu, Yasemın Gorgulu, Vuslat Pelitli Gurlu, Rugül Kose Cinar, Sadik Altan Ozal, Okan Çaliyurt
PURPOSE: To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs. METHODS: The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT)...
December 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29276354/multidimensional-approaches-for-a-case-of-severe-adult-obsessive-compulsive-disorder
#8
Zhongyong Shi, Xinchun Mei, Yingbo Zhu, Yu Shuai, Yupeng Chen, Yujie Wu, Yuan Shen
Obsessive-compulsive disorder (OCD) is a chronic, distressing and substantially impairing neuropsychiatric disorder, characterized by obsessions or compulsions. The current case describes a 44-year-old adult female diagnosed with OCD. The patient had an incomplete response to several SSRIs alone during her past treatment, and led a poor-quality life for at least three years. Current multidimensional approaches, including combined cognitive behavioral therapy (CBT) and the Selective Serotonin Reuptake Inhibitor (SSRI, Sertraline) with a small dose of antipsychotics (Aripiprazole) for augmentation, as well as familial support and resources from the internet were provided for the patient for six months...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29276014/early-selective-serotonin-reuptake-inhibitors-for-recovery-after-stroke-a-meta-analysis-and-trial-sequential-analysis
#9
Si-Chun Gu, Chang-De Wang
BACKGROUND: Potential benefits and risks of early (≤30 days from stroke onset) selective serotonin reuptake inhibitors (SSRIs) treatment for neurologic functional recovery after stroke are not fully understood. METHODS: We searched PubMed, Embase, and the Cochrane Library to identify randomized controlled trials that assessed SSRI medications during the initial ictus after stroke versus placebo. Primary outcome was decrease in National Institutes of Health Stroke Scale (NIHSS) score...
December 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29275337/risk-of-autism-spectrum-disorder-in-offspring-following-paternal-use-of-selective-serotonin-reuptake-inhibitors-before-conception-a-population-based-cohort-study
#10
Fen Yang, Jianping Chen, Mao-Hua Miao, Wei Yuan, Lin Li, Hong Liang, Vera Ehrenstein, Jiong Li
OBJECTIVE: The present study aimed to examine the association between paternal selective serotonin reuptake inhibitor (SSRI) use before conception and the risk of autism spectrum disorder (ASD) in offspring. DESIGN: A population-based cohort study. METHODS: We conducted a cohort study of 669 922 children born from 1998 to 2008, with follow-up throughout 2013. Based on Danish national registers, we linked information on paternal use of SSRIs, ASD diagnosed in children and a range of potential confounders...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29275022/-psychiatric-comorbidities-in-epilepsy
#11
Bertrand de Toffol, Coraline Hingray, Julien Biberon, Wissam El-Hage
Psychiatric comorbidities are overrepresented in people suffering from epilepsy in comparison to the general population. There is a two-way link between epilepsy and psychiatric disorders. Psychiatric symptomatology is specific in epilepsy, according to the chronology of symptoms in relation to the seizure (inter, pre- or postictal). Easy to use, fast and efficient self-administered questionnaires are available to evaluate depressive (NDDI-E) and generalized anxiety disorder (GAD-7) symptoms. Selective serotonin reuptake inhibitors (SSRIs) are not proconvulsant and can be safely used to treat depressive or anxious disorders...
December 20, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29274375/meta-analysis-risk-of-dry-mouth-with-second-generation-antidepressants
#12
Kiley Cappetta, Chad Beyer, Jessica A Johnson, Michael H Bloch
OBJECTIVE: The goal of this meta-analysis was to quantify the risk of dry mouth associated with commonly prescribed antidepressant agents and examine the potential implications of medication class, dose, and pharmacodynamics and dose on risk of treatment-induced dry mouth. DATA SOURCES AND STUDY SELECTION: A PubMed search was conducted to identify double-blind, randomized, placebo-controlled trials examining the efficacy and tolerability of second generation antidepressant medications for adults with depressive disorders, anxiety disorders, and OCD...
December 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29273074/use-of-prescription-drugs-and-risk-of-postoperative-red-blood-cell-transfusion-in-breast-cancer-patients-a-danish-population-based-cohort-study
#13
Anne Marie L Thomsen, Alma B Pedersen, Nickolaj R Kristensen, Bjarne Kuno Møller, Christian Erikstrup, Peer M Christiansen, Mette Nørgaard, Deirdre Cronin-Fenton
BACKGROUND: Several frequently used prescription drugs may affect bleeding risk. We investigated use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins and risk of postoperative red blood cell transfusion in breast cancer patients. METHODS: Using Danish population-based registries, we identified a cohort of women who underwent surgery for primary breast cancer (n = 22,238) during 2005-2012 and ascertained their use of aspirin, NSAIDs, SSRIs, and statins...
December 22, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29273063/nitrous-oxide-n2o-and-subsequent-open-label-ssri-treatment-of-adolescents-with-depression-notad-study-protocol-for-a-randomised-controlled-trial
#14
Richard M Stewart, Janice W Y Wong, Kevin C Runions, Pradeep Rao, Julia K Moore, Simon R Davies, Britta S von Ungern-Sternberg, David Sommerfield, Florian Daniel Zepf
BACKGROUND: The first line of pharmacological treatment for severe depressive disorders in young people is selective serotonin reuptake inhibitors (SSRIs). However, beneficial clinical effects are rarely observed before several weeks into treatment. Nitrous oxide (N2O) has a long-standing safety record for pain relief and has been used in adults and young people. In adults with severe treatment-resistant depression, a single dose of N2O had significant antidepressant effects, with maximum antidepressant effects observed 24 h after administration...
December 22, 2017: Trials
https://www.readbyqxmd.com/read/29244058/antidepressant-use-and-cognitive-outcomes-in-very-old-women
#15
Yue Leng, Susan J Diem, Katie L Stone, Kristine Yaffe
Background: Antidepressant use is very common in the elderly, but the effects of antidepressants on cognition in the elderly are controversial with some studies suggesting harm and others protection. We aimed to investigate the association between different antidepressant use and change in cognition and risk of mild cognitive impairment (MCI) or dementia in very old women. Methods: We examined 1,234 community-dwelling women (mean age 83.2 years) from the Study of Osteoporotic Fractures...
December 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29241655/citalopram-restores-short-term-memory-deficit-and-non-cognitive-behaviors-in-app-ps1-mice-while-halting-the-advance-of-alzheimer-s-disease-like-pathology
#16
Qin Zhang, Chen Yang, Tianyao Liu, Liang Liu, Fen Li, Yulong Cai, Keyi Lv, Xin Li, Junwei Gao, Dayu Sun, Haiwei Xu, Qingwu Yang, Xiaotang Fan
Alzheimer's disease (AD) is the most common cause of dementia. In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in AD. Here, we show that complex behavioral deficits in 6-month-old APPswe/PSEN1dE9 (APP/PS1) mice include impairments in object recognition, deficient social interaction, increased depression and buried marbles. Citalopram, one of the selective serotonin reuptake inhibitors (SSRIs), ameliorated the amyloid deposition in AD patients and transgenic animal models...
December 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29238221/selective-serotonin-reuptake-inhibitors-and-the-risk-of-hepatocellular-carcinoma-in-hepatitis-b-virus-infected-patients
#17
Chia-Ming Chang, Ming-Shun Hsieh, Tsung-Chieh Yang, Vivian Chia-Rong Hsieh, Jen-Huai Chiang, Hsien-Hao Huang, Chorng-Kuang How, Sung-Yuan Hu, David Hung-Tsang Yen
Background: This study aimed to investigate the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Methods: We conducted a population-based cohort study by using claims data from the Taiwan National Health Insurance Research Database (NHIRD). The study cohort comprised 1380 newly diagnosed HBV-infected patients with SSRI use who were frequency matched by age, sex, liver cirrhosis, and index year with HBV-infected patients without SSRI use in the comparison cohort...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29229680/prenatal-paternal-selective-serotonin-reuptake-inhibitors-use-and-risk-of-adhd-in-offspring
#18
Fen Yang, Hong Liang, Jianping Chen, Maohua Miao, Wei Yuan, Mette Nørgaard, Jiong Li
OBJECTIVES: It has been shown that maternal prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) may be a risk factor for attention-deficit/hyperactivity disorder (ADHD) in offspring. Our goal was to examine whether paternal SSRI use before conception increases the risk of ADHD in offspring. METHODS: On the basis of Danish national registers, we conducted a cohort study of 781 470 singletons born between 1996 and 2008 with follow-up throughout 2013...
December 11, 2017: Pediatrics
https://www.readbyqxmd.com/read/29203333/perinatal-fluoxetine-increases-hippocampal-neurogenesis-and-reverses-the-lasting-effects-of-pre-gestational-stress-on-serum-corticosterone-but-not-on-maternal-behavior-in-the-rat-dam
#19
Mary Gemmel, Danny Harmeyer, Eszter Bögi, Marianne Fillet, Lesley A Hill, Geoffrey L Hammond, Thierry D Charlier, Jodi L Pawluski
There is increasing evidence that mental health concerns, stress-related mental illnesses, and parental stress prior to conception have long-term effects on offspring outcomes. However, more work is needed to understand how pre-gestational stress might affect neurobehavioral outcomes in the mother. We investigated how chronic stress prior to gestation affects the maternal behavior and related physiology, and aimed to determine the role that perinatal SSRIs may have in altering these stress effects. To do this, female Sprague-Dawley rats were subject to chronic unpredictable stress (CUS) prior to breeding and during the perinatal period they were administered fluoxetine (10mg/kg/day)...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29202974/embryo-aneuploidy-is-not-impacted-by-selective-serotonin-reuptake-inhibitor-exposure
#20
Carlos Hernandez-Nieto, Joseph Lee, Taraneh Nazem, Dmitry Gounko, Alan Copperman, Benjamin Sandler
OBJECTIVE: To study whether maternal exposure to selective serotonin reuptake inhibitors (SSRIs) has any influence on rates of blastocyst aneuploidy and/or in vitro fertilization (IVF) cycle outcomes. DESIGN: Retrospective cohort analysis. SETTING: Private and academic IVF center. PATIENT(S): Patients who underwent IVF with preimplantation genetic treatment with trophectoderm biopsy (n = 4,355 cycles) and patients who underwent a single-embryo transfer (SET) between January-2012 and June-2017 (n = 2,132 cycles)...
December 2017: Fertility and Sterility
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