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https://www.readbyqxmd.com/read/28917161/maternal-ssri-exposure-increases-the-risk-of-autistic-offspring-a-meta-analysis-and-systematic-review
#1
S Andalib, M R Emamhadi, S Yousefzadeh-Chabok, S K Shakouri, P F Høilund-Carlsen, M S Vafaee, T M Michel
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used to preclude maternal pregnancy depression. There is a growing body of literature assessing the association of prenatal exposure to SSRIs with autism spectrum disorder (ASD). The present systematic review and meta-analysis reviewed the medical literature and pooled the results of the association of prenatal exposure to SSRIs with ASD. METHODS: Published investigations in English by June 2016 with keywords of selective serotonin reuptake inhibitors, SSRI, autism spectrum disorder, ASD, pregnancy, childhood, children, neurodevelopment were identified using databases PubMed and PMC, MEDLINE, EMBASE, SCOPUS, and Google Scholar...
June 20, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28913588/efficacy-of-pde5is-and-ssris-in-men-with-premature-ejaculation-a-new-systematic-review-and-five-meta-analyses
#2
Yi Sun, Lu Yang, Yige Bao, Zhenhua Liu, Liangren Liu, Qiang Wei
PURPOSE: To clarify the efficacy of phosphodiesterase-5 inhibitors (PDE5Is) and selective serotonin reuptake inhibitors (SSRIs) in men with premature ejaculation (PE). METHODS: We searched the PubMed, Embase, and Cochrane Library databases to identify all randomized, controlled trials (RCTs) and compared the results, including intravaginal ejaculation latency time, satisfaction, intercourse per-week and side effects after treatment with PDE5I or SSRIs versus placebo, combined use of PDE5I with SSRIs versus PDE5I or SSRIs alone, and PDE5I versus SSRIs for treating PE...
September 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28910072/mapping-the-binding-site-for-escitalopram-and-paroxetine-in-the-human-serotonin-transporter-using-genetically-encoded-photocrosslinkers
#3
Hafsteinn Rannversson, Jacob Andersen, Benny Bang-Andersen, Kristian Strømgaard
In spite of the important role of the human serotonin transporter (hSERT) in depression treatment, the molecular details of how antidepressant drugs bind are still not completely understood, in particular those related to potential high- and low-affinity binding sites in hSERT. Here, we utilize amber codon suppression in hSERT to encode the photocrosslinking unnatural amino acid p-azido-L-phenylalanine into the suggested high- and low-affinity binding sites. We then employ UV-induced crosslinking with azF to map the binding site of escitalopram and paroxetine, two prototypical selective serotonin reuptake inhibitors (SSRIs)...
September 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28900387/social-isolation-in-early-versus-late-adolescent-mice-is-associated-with-persistent-behavioral-deficits-that-can-be-improved-by-neurosteroid-based-treatment
#4
Andrea Locci, Philippe Geoffroy, Michel Miesch, Ayikoe-Guy Mensah-Nyagan, Graziano Pinna
Early trauma and stress exposure during a critical period of life may increase the risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) in adulthood. The first-choice treatment for MDD and PTSD are selective serotonin reuptake inhibitor (SSRI) antidepressants. Unfortunately, half of MDD and PTSD patients show resistance to the therapeutic effects of these drugs and more efficient treatments are essential. Both MDD and PTSD patients present reduced levels of allopregnanolone (Allo), a potent endogenous positive allosteric modulator of GABA action at GABAA receptors which are normalized by SSRIs in treatment responders...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28899417/serotonin-augmentation-therapy-by-escitalopram-has-minimal-effects-on-amyloid-%C3%AE-levels-in-early-stage-alzheimer-s-like-disease-in-mice
#5
Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch, Bente Finsen
BACKGROUND: Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer's disease (AD). Accumulation of toxic amyloid-β (Aβ) species is a hallmark of AD and an instigator of pathology. Serotonin (5-HT) augmentation therapy by treatment with selective serotonin reuptake inhibitors (SSRIs) in patients with AD has had mixed success in improving cognitive function, whereas SSRI administration to mice with AD-like disease has been shown to reduce Aβ pathology...
September 12, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28893095/efficacy-of-antidepressants-bias-in-randomized-clinical-trials-and-related-issues
#6
Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Tae-Youn Jun, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae
Countless antidepressant randomized trials were conducted and showed statistically significant benefits of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) over placebo. Meanwhile, critics are increasing regarding the efficacy of antidepressants in the treatment of MDD because at least a proportion of clinical trials could be hampered by various biases. In contrast, number of failed trials is increasing in the recent years which have made developing psychiatric medications progressively more time-consuming and expensive...
September 14, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28892067/association-of-the-serotonin-transporter-linked-polymorphic-region-genotype-with-lower-bone-mineral-density
#7
M I Lapid, S Kung, M A Frye, J M Biernacka, J R Geske, M T Drake, M D Jankowski, B L Clarke
The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) S allele is linked to pathogenesis of depression and slower response to selective serotonin reuptake inhibitors (SSRIs); depression and SSRIs are independently associated with bone loss. We aimed to determine whether 5-HTTLPR was associated with bone loss. This cross-sectional study included psychiatric patients with both 5-HTTLPR analysis and bone mineral density (BMD) assessment (hip and spine Z-scores if age <50 years and T-scores if ⩾50 years)...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28878923/a-31-year-old-with-idiopathic-reversible-cerebral-vasoconstriction-syndrome
#8
Ihtesham A Qureshi, Mohtashim A Qureshi, Obiajulu Kanu, Salvador Cruz-Flores
In our patient with reversible cerebral vasoconstriction syndrome (RCVS) syndrome, presenting with thunderclap-like headache, there is a possibility to be readily confused with migraine. Initiating treatment with selective serotonin reuptake inhibitors (SSRIs) and triptans can further aggravate the condition. Therefore, it is essential to understand the nature and type of headache and correlate the clinical findings with imaging studies.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28877964/constitutive-activity-of-5-ht2c-receptors-is-present-following-incomplete-spinal-cord-injury-but-is-not-modified-after-chronic-ssri-or-baclofen-treatment
#9
Vicki Maria Tysseling, David A Klein, Rebecca Imhoff-Manuel, Marin Manuel, Charles J Heckman, Matthew C Tresch
Following spinal cord injury (SCI), reflexes become hyperexcitable, leading to debilitating muscle spasms and compromised motor function. Previous work has described adaptations in spinal systems that might underlie this hyperexcitability, including an increase in constitutively active 5-HT2C receptors in spinal motoneurons. That work, however, examined adaptations following complete transection SCI, whereas SCI in humans is usually anatomically and functionally incomplete. We therefore evaluated whether constitutive activity of 5-HT2C receptors contributes to reflex hyperexcitability in an incomplete compression model of SCI and to spasms in vitro and in vivo...
September 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28863203/purls-ssris-for-depression-heart-failure-patients-not-so-fast
#10
Jason Ricco, Janice Benson, Shailendra Prasad
This study should put to rest the practice of starting SSRIs in depressed patients with heart failure in an attempt to affect CVD outcomes.
September 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28859218/incidence-of-early-anxiety-aggravation-in-trials-of-selective-serotonin-reuptake-inhibitors-in-depression
#11
J Näslund, F Hieronymus, J F Emilsson, A Lisinski, S Nilsson, E Eriksson
OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) may aggravate anxiety and agitation during the first days of treatment but the frequency of such reactions remains unknown. METHOD: We analysed patient-level data from placebo-controlled trials of sertraline, paroxetine or citalopram in depressed adults. Somatic anxiety, psychic anxiety and psychomotor agitation as assessed using the Hamilton Depression Rating Scale (HDRS) were analysed in all trials (n = 8262); anxiety-related adverse events were analysed in trials investigating paroxetine and citalopram (n = 5712)...
August 31, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28859190/comparative-effectiveness-and-safety-of-cognitive-behavioral-therapy-and-pharmacotherapy-for-childhood-anxiety-disorders-a-systematic-review-and-meta-analysis
#12
Zhen Wang, Stephen P H Whiteside, Leslie Sim, Wigdan Farah, Allison S Morrow, Mouaz Alsawas, Patricia Barrionuevo, Mouaffaa Tello, Noor Asi, Bradley Beuschel, Lubna Daraz, Jehad Almasri, Feras Zaiem, Laura Larrea-Mantilla, Oscar J Ponce, Annie LeBlanc, Larry J Prokop, Mohammad Hassan Murad
Importance: Childhood anxiety is common. Multiple treatment options are available, but existing guidelines provide inconsistent advice on which treatment to use. Objectives: To evaluate the comparative effectiveness and adverse events of cognitive behavioral therapy (CBT) and pharmacotherapy for childhood anxiety disorders. Data Sources: We searched MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and SciVerse Scopus from database inception through February 1, 2017...
August 31, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28858536/serotonin-and-brain-function-a-tale-of-two-receptors
#13
R L Carhart-Harris, D J Nutt
Previous attempts to identify a unified theory of brain serotonin function have largely failed to achieve consensus. In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-HT1A and 5-HT2A receptors. We propose that passive coping (i.e. tolerating a source of stress) is mediated by postsynaptic 5-HT1AR signalling and characterised by stress moderation...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28856398/association-of-use-of-selective-serotonin-reuptake-inhibitors-with-risk-of-acute-pancreatitis-a-case-control-study-in-taiwan
#14
Hsien-Feng Lin, Kuan-Fu Liao, Ching-Mei Chang, Cheng-Li Lin, Shih-Wei Lai
BACKGROUND AND OBJECTIVES: Few studies have reported the association of the use of selective serotonin reuptake inhibitors (SSRIs) with acute pancreatitis. We conducted a population-based case-control study to explore this relationship. METHODS: In this study, 4631 cases with first attack of acute pancreatitis and 4631 controls without acute pancreatitis were selected using a randomly sampled cohort of one million health insurance enrollees from 2000 to 2013. Both cases and controls were aged 20-84 years and were matched with sex, age, comorbidities, and index year of diagnosis of acute pancreatitis...
August 30, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28854296/efficacy-and-safety-of-selective-serotonin-reuptake-inhibitors-serotonin-norepinephrine-reuptake-inhibitors-and-placebo-for-common-psychiatric-disorders-among-children-and-adolescents-a-systematic-review-and-meta-analysis
#15
Cosima Locher, Helen Koechlin, Sean R Zion, Christoph Werner, Daniel S Pine, Irving Kirsch, Ronald C Kessler, Joe Kossowsky
Importance: Depressive disorders (DDs), anxiety disorders (ADs), obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD) are common mental disorders in children and adolescents. Objective: To examine the relative efficacy and safety of selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and placebo for the treatment of DD, AD, OCD, and PTSD in children and adolescents. Data Sources: PubMed, EMBASE, PsycINFO, Web of Science, and Cochrane Database from inception through August 7, 2016...
August 30, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28844482/impact-of-selective-serotonin-reuptake-inhibitors-on-neural-crest-stem-cell-formation
#16
Cecilia Vichier-Guerre, Margaret Parker, Yael Pomerantz, Richard H Finnell, Robert M Cabrera
The use of antidepressants in pregnant women is rising, with rates up to 7.5% in the United States. Selective serotonin reuptake inhibitors (SSRIs) are currently the most common antidepressant prescribed to pregnant women. The teratogenic effects of SSRI exposure are debated because of discrepancies in epidemiological studies. As an alternative to epidemiological and animal studies, human embryonic stem cell research (hESC) provides a human-based experimental model to examine the risks of prenatal SSRI exposure...
August 24, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28832181/treatment-of-pediatric-acute-onset-neuropsychiatric-disorder-in-a-large-survey-population
#17
Denise Calaprice, Janice Tona, Tanya K Murphy
OBJECTIVE: The goal of this study was to investigate treatment histories and outcomes in a large community sample of youth with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), and, where appropriate, to examine the impact of immune deficiency on treatment outcomes. METHODS: A comprehensive internet-based survey was completed by parents or guardians of youth who had received physician diagnoses of PANS, or by young adults (age 18+) who had themselves been diagnosed by a physician (N = 698)...
August 23, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28831260/an-observational-study-of-duloxetine-versus-ssri-monotherapy-in-japanese-patients-with-major-depressive-disorder-subgroup-analyses-of-treatment-effectiveness-for-pain-depressive-symptoms-and-quality-of-life
#18
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: To examine how clinical and demographic patient baseline characteristics influence effectiveness of duloxetine versus selective serotonin reuptake inhibitor (SSRI) treatment, in real-world Japanese clinical settings of patients with major depressive disorder (MDD) and associated painful physical symptoms (PPS). METHODS: This was a multicenter, 12-week, prospective, observational study in patients with MDD (Quick Inventory of Depressive Symptomatology ≥16) and at least moderate PPS (Brief Pain Inventory-Short Form [BPI-SF] average pain ≥3)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28831259/an-observational-study-of-duloxetine-versus-ssri-monotherapy-for-the-treatment-of-painful-physical-symptoms-in-japanese-patients-with-major-depressive-disorder-primary-analysis
#19
Atsushi Kuga, Toshinaga Tsuji, Shinji Hayashi, Mako Matsubara, Shinji Fujikoshi, Hirofumi Tokuoka, Aki Yoshikawa, Rodrigo Escobar, Kazuhide Tanaka, Takaharu Azekawa
OBJECTIVE: The objective of this study was to assess the effectiveness of duloxetine monotherapy, in comparison with selective serotonin reuptake inhibitor (SSRI) monotherapy, in the treatment of painful physical symptoms (PPS) in Japanese patients with major depressive disorder (MDD) in real-world clinical settings. METHODS: This was a multicenter, 12-week prospective, observational study. This study enrolled MDD patients with at least moderate PPS, defined as a Brief Pain Inventory-Short Form (BPI-SF) average pain score (item 5) ≥3...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28819255/mouse-strain-differences-in-ssri-sensitivity-correlate-with-serotonin-transporter-binding-and-function
#20
Zeng-Liang Jin, Xiao-Fei Chen, Yu-Hua Ran, Xiao-Rong Li, Jie Xiong, Yuan-Yuan Zheng, Na-Na Gao, Yun-Feng Li
Selective serotonin reuptake inhibitors (SSRIs) bind 5-HT transporters, leading to the accumulation of 5-HT and amelioration of depression. Although different mouse strains show varying sensitivity to SSRIs in mouse models of depression, the underlying mechanism of these strain differences remains unclear. Here, the SSRI citalopram dose-dependently reduced immobility time in both the FST and TST in DBA/2J mice but not C57BL/6J mice, whereas fluoxetine showed the opposite results. Paroxetine similarly reduced immobility time in both strains...
August 17, 2017: Scientific Reports
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