keyword
MENU ▼
Read by QxMD icon Read
search

Hepatocyte growth factor

keyword
https://www.readbyqxmd.com/read/28522754/met-exon-14-mutation-encodes-an-actionable-therapeutic-target-in-lung-adenocarcinoma
#1
Xinyuan Lu, Nir Peled, John Greer, Wei Wu, Peter Choi, Alice H Berger, Sergio Wong, Kuang-Yu Jen, Youngho Seo, Byron Hann, Angela Brooks, Matthew Meyerson, Eric A Collisson
Targeting somatically activated oncogenes has revolutionized the treatment of non-small cell lung cancer (NSCLC). Mutations in the gene mesenchymal-epithelial transition (MET) near the exon 14 splice sites are recurrent in lung adenocarcinoma and cause exon skipping (METΔ14). Here we analyzed 4,422 samples from 12 different malignancies to estimate the rate of said exon skipping. METΔ14 mutation and transcript were most common in lung adenocarcinoma. Endogenously expressed levels of METΔ14 transformed human epithelial lung cells in a Hepatocyte growth factor (HGF)-dependent manner...
May 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28508871/non-cell-autonomous-activation-of-il-6-stat3-signaling-mediates-fgf19-driven-hepatocarcinogenesis
#2
Mei Zhou, Hong Yang, R Marc Learned, Hui Tian, Lei Ling
Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is the second leading cause of cancer mortality worldwide. Fibroblast Growth Factor 19 (FGF19) is one of the most frequently amplified genes in HCC patients. Moreover, mice expressing an FGF19 transgene have been shown to develop HCC. However, the downstream signalling pathways that mediate FGF19-dependent tumorigenesis remain to be deciphered. Here we show that FGF19 triggers a previously unsuspected, non-cell-autonomous program to activate STAT3 signalling in hepatocytes through IL-6 produced in the liver microenvironment...
May 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28506098/long-term-influence-of-sialoadenectomy-on-the-liver-of-male-albino-rat
#3
Abeer A Mahmoud, Ebtehal Z Hassan, Eman M Askar
Epidermal growth factor is an endocrine product of the submandibular gland; the liver is an important target of its action and is affected by sialoadenectomy. Thirty rats were used in this study and divided into group I (sham-operated animals), group II (sialoadenectomy after 4 weeks), and group III (sialoadenectomy after 10 weeks). Liver samples were processed for light and electron microscope examination. Sialoadenectomy induced mild-to-moderate liver damage which persists up to 10 weeks after the operation...
May 16, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28504963/novel-pleiotropic-effects-of-bioactive-phospholipids-in-human-lung-cancer-metastasis
#4
Gabriela Schneider, Zachariah Payne Sellers, Kamila Bujko, Sham S Kakar, Magda Kucia, Mariusz Z Ratajczak
We previously proposed that one of the unwanted side effects of chemotherapy and radiotherapy is the increase in several peptide- and non-peptide based chemoattractants in damaged tissues, leading to induction of a prometastatic microenvironment for remaining cancer cells. Herein, we turned out our attention to a potential role of bioactive phospholipids (BphsLs), such as sphingosine-1-phosphate (S1P), ceramide-1-phosphate (C1P), lysophosphatidylcholine (LPC), and lysophosphatidic acid (LPA) in lung cancer (LC) metastasis...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28504718/a-tumor-suppressor-role-for-c-ebp%C3%AE-in-solid-tumors-more-than-fat-and-blood
#5
REVIEW
A R Lourenço, P J Coffer
The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays a critical role during embryogenesis and is thereafter required for homeostatic glucose metabolism, adipogenesis and myeloid development. Its ability to regulate the expression of lineage-specific genes and induce growth arrest contributes to the terminal differentiation of several cell types, including hepatocytes, adipocytes and granulocytes. CEBPA loss of-function mutations contribute to the development of ~10% of acute myeloid leukemia (AML), stablishing a tumor suppressor role for C/EBPα...
May 15, 2017: Oncogene
https://www.readbyqxmd.com/read/28504197/intravenous-injection-of-umbilical-cord-derived-mesenchymal-stromal-cells-attenuates-reactive-gliosis-and-hypomyelination-in-a-neonatal-intraventricular-hemorrhage-model
#6
Takeo Mukai, Yuka Mori, Takahisa Shimazu, Atsuko Takahashi, Hajime Tsunoda, Satoru Yamaguchi, Shigeru Kiryu, Arinobu Tojo, Tokiko Nagamura-Inoue
Intraventricular hemorrhage (IVH) is a frequent complication of preterm newborns, resulting in cerebral palsy and cognitive handicap as well as hypoxic ischemic encephalopathy and periventricular leukomalacia. In this study, we investigated the restorative effect on neonatal IVH by umbilical cord-derived mesenchymal stromal cells (UC-MSCs) cultured in serum-free medium (RM medium) for clinical application. UC-MSCs were cultured with αMEM medium supplemented with FBS or RM. A neonatal IVH mouse model at postnatal day 5 was generated by intraventricular injection of autologous blood, and mice were intravenously administered 1×10(5) UC-MSCs two days after IVH...
May 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28502469/hepatocyte-growth-factor-suppresses-inflammation-and-promotes-epithelium-repair-in-corneal-injury
#7
Masahiro Omoto, Kunal Suri, Afsaneh Amouzegar, Mingshun Li, Kishore R Katikireddy, Sharad K Mittal, Sunil K Chauhan
Corneal injuries are among the major causes of ocular morbidity and vision impairment. Optimal epithelial wound healing is critical for the integrity and transparency of the cornea after injury. Hepatocyte growth factor (HGF) is a mitogen and motility factor that primarily regulates epithelial cell function. Herein, we investigate the effect of HGF on proliferation of corneal epithelial cells (CECs) in inflamed conditions both in vitro and in vivo. We demonstrate that HGF not only promotes CEC proliferation in homeostatic conditions but also reverses the anti-proliferative effect of the inflammatory environment on these cells...
May 10, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28500773/the-energy-sensing-lkb1-ampk%C3%AE-1-pathway-regulates-igf1-secretion-and-consequent-activation-of-the-igf1r-pkb-pathway-in-primary-hepatocytes
#8
Liang Chen, Qiaoli Chen, Ping Rong, Hong Yu Wang, Shuai Chen
The insulin-like growth factor 1 (IGF1) pathway has been linked with various diseases including diabetes, cancer and aging. In contrast to the well-established regulatory mechanisms controlling IGF1 expression, molecular mechanisms regulating of its secretion is not fully understood. The AMP-activated protein kinase (AMPK) is a key energy sensor, and accumulative evidence shows that AMPK is an attractive therapeutic target for treatment of diabetes, cancer and aging. Here we found that deficiency of AMPK promoted IGF1 secretion in mouse primary hepatocytes...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28498453/the-inhibition-of-microrna-15a-suppresses-hepatitis%C3%A2-b-virus-associated-liver-cancer-cell-growth-through-the-smad-tgf-%C3%AE-pathway
#9
Yan Wang
In the present study, the role of microRNA‑15a (miR‑15a) was investigated in hepatitis B virus (HBV)‑associated liver cancer. The results revealed that the expression levels of miR-15a were increased in HBV-associated liver cancer tissues compared with the levels in normal tumor‑adjacent tissues. Moreover, Smad-7 protein expression in patients with HBV-associated liver cancer was higher than that in normal tumor-adjacent tissues. In addition, miR-15a expression and Smad-7 protein expression were increased in HepG2 hepatocellular carcinoma cells compared with that noted in L-02 normal hepatocytes...
May 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28498421/molecular-analysis-of-the-mouse-brain-exposed-to-chronic-mild-stress-the-influence-of-hepatocyte-nuclear-factor-4%C3%AE-on-physiological-homeostasis
#10
Kaoru Ikubo, Kyosuke Yamanishi, Nobutaka Doe, Takuya Hashimoto, Miho Sumida, Yuko Watanabe, Yosif El-Darawish, Wen Li, Haruki Okamura, Hiromichi Yamanishi, Hisato Matsunaga
Major depressive disorder (MDD) is a prevalent disorder that causes considerable disability in social functioning and is a risk factor for physical diseases. Recent clinical reports have demonstrated a marked association between MDD and physiological dyshomeostasis induced by metabolic disorders, including diabetes, hormone abnormalities and autoimmune diseases. The authors of the present study have previously analyzed comparative gene expression profiles in the prefrontal cortex (PFC) of a chronic mild stress (CMS) animal model of MDD...
May 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28497393/effect-of-miscanthus-sinensis-var-purpurascens-flower-extract-on-proliferation-and-molecular-regulation-in-human-dermal-papilla-cells-and-stressed-c57bl-6-mice
#11
GiHee Jeong, William A Boisvert, Mei-Zhu Xi, Yi-Lin Zhang, Young-Bin Choi, Sunghun Cho, Sanghyun Lee, Changsun Choi, Bog-Hieu Lee
OBJECTIVES: To investigate the hair growth-promoting effect of Miscanthus sinensis var. purpurascens (MSP) flower extracton on in vitro and in vivo models. METHODS: MSP flower extract was extracted in 99.9% methanol and applied to examine the proliferation of human dermal papilla cells (hDPCs) in vitro at the dose of 3.92-62.50 μg/mL and hair growth of C57BL/6 mice in vivo at the dose of 1000 μg/mL. The expression of transforming growth factor β1 (TGF-β1), hepatocyte growth factor (HGF), β-catenin, substance P was measured by relative quantitative realtime polymerase chain reaction...
May 11, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28488786/gadoxetic-acid-enhanced-magnetic-resonance-imaging-reflects-co-activation-of-%C3%AE-catenin-and-hepatocyte-nuclear-factor-4%C3%AE-in-hepatocellular-carcinoma
#12
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Wataru Koda, Tetsuya Minami, Dai Inoue, Kotaro Yoshida, Taro Yamashita, Tatsuya Yamashita, Shuichi Kaneko, Hiroyuki Takamura, Tetsuo Ohta, Hiroko Ikeda, Yasunori Sato, Yasuni Nakanuma, Kenichi Harada, Ryuichi Kita, Toshifumi Gabata
AIM: The aim of this study is to clarify the correlation of the co-activation of β-catenin and hepatocyte nuclear factor (HNF) 4α with the findings of gadoxetic acid enhanced MRI, organic anion transporting polypeptide (OATP) 1B3 expression and histological differentiation grade in hepatocellular carcinoma (HCC). METHODS: Surgically resected 196 HCC in 174 patients were enrolled in this study. HCC were classified into four groups by immunohistochemical expression of β-catenin, glutamine synthetase (GS) and HNF4α: β-catenin/GS (positive: +) HNF4α (+), β-catenin/GS (+) HNF4α (negative: -), β-catenin/GS (-) HNF4α (+) and β-catenin/GS (-) HNF4α (-)...
May 10, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28488569/gene-expression-in-the-liver-remnant-is-significantly-affected-by-the-size-of-partial-hepatectomy-an-experimental-rat-study
#13
Michelle Meier, Anders Riegels Knudsen, Kasper Jarlhelt Andersen, Niels Christian Bjerregaard, Uffe Birk Jensen, Frank Viborg Mortensen
<p>Background Extended hepatectomies may result in post-hepatectomy liver failure, a conditionwith a high mortality. The main purpose of the present study was to investigate and compare the gene expression profiles in rats subjected to increasing size of partial hepatectomy.</p><p>Methods 30 Wistar rats were subjected to 30%, 70%, or 90% partial hepatectomy, sham operation or no operation. 24 hours following resection liver tissue was harvested and genome wide expression analysis was performed...
May 9, 2017: Gene Expression
https://www.readbyqxmd.com/read/28486967/pseudoxanthoma-elasticum
#14
REVIEW
Dominique P Germain
Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein leads to ectopic mineralization that is most apparent in the elastic tissues of the skin, eyes and blood vessels. The clinical prevalence of PXE has been estimated at between 1 per 100,000 and 1 per 25,000, with slight female predominance. The first clinical sign of PXE is almost always small yellow papules on the nape and sides of the neck and in flexural areas...
May 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28486662/elevated-ackr2-expression-is-a-common-feature-of-inflammatory-arthropathies
#15
Helen M Baldwin, Mark D Singh, Veronica Codullo, Vicky King, Hilary Wilson, Iain McInnes, Gerard J Graham
Objectives.: Chemokines are essential contributors to leucocyte accumulation at sites of inflammatory pathology. Interfering with chemokine or chemokine receptor function therefore represents a plausible therapeutic option. However, our currently limited understanding of chemokine orchestration of inflammatory responses means that such therapies have not yet been fully developed. We have a particular interest in the family of atypical chemokine receptors that fine-tune, or resolve, chemokine-driven responses...
May 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28486435/regulated-entry-of-hepatitis-c-virus-into-hepatocytes
#16
REVIEW
Zhijiang Miao, Zhenrong Xie, Jing Miao, Jieyu Ran, Yue Feng, Xueshan Xia
Hepatitis C virus (HCV) is a model for the study of virus-host interaction and host cell responses to infection. Virus entry into hepatocytes is the first step in the HCV life cycle, and this process requires multiple receptors working together. The scavenger receptor class B type I (SR-BI) and claudin-1 (CLDN1), together with human cluster of differentiation (CD) 81 and occludin (OCLN), constitute the minimal set of HCV entry receptors. Nevertheless, HCV entry is a complex process involving multiple host signaling pathways that form a systematic regulatory network; this network is centrally controlled by upstream regulators epidermal growth factor receptor (EGFR) and transforming growth factor β receptor (TGFβ-R)...
May 9, 2017: Viruses
https://www.readbyqxmd.com/read/28485480/shikonin-inhibited-migration-and-invasion-of-human-lung-cancer-cells-via-suppression-of-c-met-mediated-epithelial-to-mesenchymal-transition
#17
Yei-San Hsieh, Chiung-Ho Liao, Wan-Shen Chen, Jih-Tung Pai, Meng-Shih Weng
Epithelial-to-mesenchymal transition (EMT) is a major process to regulate cell migration and invasion. Inhibition of epidermal growth factor receptor (EGFR)-mediated EMT by tyrosine kinase inhibitors (TKIs) is a strategy to prevent lung cancer invasion. However, drug resistance is emerged and accelerated invasion through other signaling bypassing EGFR after TKIs therapy. c-Met signaling pathway is highly activated in EGFR-mutated lung cancer cells. Targeting c-Met signaling pathway may be a strategy to suppress EGFR-independent migration and invasion for lung cancer therapy...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28485003/analysis-of-progress-and-challenges-for-various-patterns-of-c-met-targeted-molecular-imaging-a-systematic-review
#18
REVIEW
Zhaoguo Han, Yongyi Wu, Kai Wang, Yadi Xiao, Zhen Cheng, Xilin Sun, Baozhong Shen
BACKGROUND: Mesenchymal-epithelial transition factor also named c-MET is a receptor tyrosine kinase for the hepatocyte growth factor that plays a pivotal role in tumorigenesis. c-MET-targeted therapies have been tested in preclinical models and patients, with significant benefits for cancer treatment. In recent years, many studies have shown that the expression level and activation status of c-MET are closely correlated to c-MET-targeted therapy response and clinical prognosis, thus highlighting the importance of evaluating the c-MET status during and prior to targeted therapy...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28477027/efficacy-and-safety-of-different-molecular-targeted-agents-based-on-chemotherapy-for-gastric-cancer-patients-treatment-a-network-meta-analysis
#19
Zheng Ren, Jinping Sun, Xinfang Sun, Hongtao Hou, Ke Li, Quanxing Ge
Increasing numbers of reports have been published to demonstrate that molecular targeted agents are able to improve the efficacy of chemotherapy in gastric cancer. This network meta-analysis aimed to evaluate the efficacy and safety of different molecular targeted agents, which were divided into six groups based on the targets including hepatocyte growth factor receptor (c-MET), vascular endothelial factor and its receptor (VEGF/VEGFR), human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), mammalian target of rapamycin (mTOR) and tyrosine kinase inhibitor (TKI)...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28475121/hgf-met-signaling-in-cancer-invasion-the-impact-on-cytoskeleton-remodeling
#20
REVIEW
Chuan Xiang, Junxia Chen, Panfeng Fu
The invasion of cancer cells into surrounding tissue and the vasculature is essential for tumor metastasis. Increasing evidence indicates that hepatocyte growth factor (HGF) induces cancer cell migration and invasion. A broad spectrum of mechanisms underlies cancer cell migration and invasion. Cytoskeletal reorganization is of central importance in the development of the phenotype of cancer cells with invasive behavior. Through their roles in cell mechanics, intracellular trafficking, and signaling, cytoskeleton proteins participate in all essential events leading to cell migration...
May 5, 2017: Cancers
keyword
keyword
3057
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"