keyword
https://read.qxmd.com/read/37757828/influence-of-autozygosity-on-common-disease-risk-across-the-phenotypic-spectrum
#21
JOURNAL ARTICLE
Daniel S Malawsky, Eva van Walree, Benjamin M Jacobs, Teng Hiang Heng, Qin Qin Huang, Ataf H Sabir, Saadia Rahman, Saghira Malik Sharif, Ahsan Khan, Maša Umićević Mirkov, Hiroyuki Kuwahara, Xin Gao, Fowzan S Alkuraya, Danielle Posthuma, William G Newman, Christopher J Griffiths, Rohini Mathur, David A van Heel, Sarah Finer, Jared O'Connell, Hilary C Martin
Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH ) and common diseases in Genes & Health (n = 23,978 British South Asians), UK Biobank (n = 397,184), and 23andMe. We show that restricting analysis to offspring of first cousins is an effective way of reducing confounding due to social/environmental correlates of FROH . Within this group in G&H+UK Biobank, we found experiment-wide significant associations between FROH and twelve common diseases...
September 20, 2023: Cell
https://read.qxmd.com/read/37749244/a-new-method-for-multiancestry-polygenic-prediction-improves-performance-across-diverse-populations
#22
JOURNAL ARTICLE
Haoyu Zhang, Jianan Zhan, Jin Jin, Jingning Zhang, Wenxuan Lu, Ruzhang Zhao, Thomas U Ahearn, Zhi Yu, Jared O'Connell, Yunxuan Jiang, Tony Chen, Dayne Okuhara, Montserrat Garcia-Closas, Xihong Lin, Bertram L Koelsch, Nilanjan Chatterjee
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal performance in non-European populations raise concerns about clinical applications and health inequities. We developed CT-SLEB, a powerful and scalable method to calculate PRSs, using ancestry-specific genome-wide association study summary statistics from multiancestry training samples, integrating clumping and thresholding, empirical Bayes and superlearning. We evaluated CT-SLEB and nine alternative methods with large-scale simulated genome-wide association studies (~19 million common variants) and datasets from 23andMe, Inc...
September 25, 2023: Nature Genetics
https://read.qxmd.com/read/37745582/genome-wide-association-studies-of-coffee-intake-in-uk-us-participants-of-european-ancestry-uncover-gene-cohort-influences
#23
Hayley H A Thorpe, Pierre Fontanillas, Benjamin K Pham, John J Meredith, Mariela V Jennings, Natasia S Courchesne-Krak, Laura Vilar-Ribó, Sevim B Bianchi, Julian Mutz, Sarah L Elson, Jibran Y Khokhar, Abdel Abdellaoui, Lea K Davis, Abraham A Palmer, Sandra Sanchez-Roige
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study ( GWAS ) of coffee intake in US-based 23andMe participants ( N =130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across thousands of biomarkers and health and lifestyle traits, then compared our results to the largest available GWAS of coffee intake from UK Biobank (UKB; N =334,659)...
September 11, 2023: medRxiv
https://read.qxmd.com/read/37633302/identification-of-genetic-risk-loci-and-causal-insights-associated-with-parkinson-s-disease-in-african-and-african-admixed-populations-a-genome-wide-association-study
#24
JOURNAL ARTICLE
Mie Rizig, Sara Bandres-Ciga, Mary B Makarious, Oluwadamilola Omolara Ojo, Peter Wild Crea, Oladunni Victoria Abiodun, Kristin S Levine, Sani Atta Abubakar, Charles Obiora Achoru, Dan Vitale, Olaleye Akinmola Adeniji, Osigwe Paul Agabi, Mathew J Koretsky, Uchechi Agulanna, Deborah A Hall, Rufus Olusola Akinyemi, Tao Xie, Mohammed Wulgo Ali, Ejaz A Shamim, Ifeyinwa Ani-Osheku, Mahesh Padmanaban, Ohwotemu Michael Arigbodi, David G Standaert, Abiodun Hamzat Bello, Marissa N Dean, Cyril Oshomah Erameh, Inas Elsayed, Temitope Hannah Farombi, Olaitan Okunoye, Michael Bimbola Fawale, Kimberley J Billingsley, Frank Aiwansoba Imarhiagbe, Pilar Alvarez Jerez, Emmanuel Uzodinma Iwuozo, Breeana Baker, Morenikeji Adeyoyin Komolafe, Laksh Malik, Paul Osemeke Nwani, Kensuke Daida, Ernest Okwundu Nwazor, Abigail Miano-Burkhardt, Yakub Wilberforce Nyandaiti, Zih-Hua Fang, Yahaya Olugbo Obiabo, Jillian H Kluss, Olanike Adedoyin Odeniyi, Dena G Hernandez, Francis Ehidiamen Odiase, Nahid Tayebi, Francis Ibe Ojini, Ellen Sidranksy, Gerald Awele Onwuegbuzie, Andrea M D'Souza, Godwin Osawaru Osaigbovo, Bahafta Berhe, Nosakhare Osemwegie, Xylena Reed, Olajumoke Olufemi Oshinaike, Hampton L Leonard, Folajimi Morenikeji Otubogun, Chelsea X Alvarado, Shyngle Imiewan Oyakhire, Simon Izuchukwu Ozomma, Sarah Chabiri Samuel, Funmilola Tolulope Taiwo, Kolawole Wasiu Wahab, Yusuf Agboola Zubair, Hirotaka Iwaki, Jonggeol Jeffrey Kim, Huw R Morris, John Hardy, Mike A Nalls, Karl Heilbron, Lucy Norcliffe-Kaufmann, Cornelis Blauwendraat, Henry Houlden, Andrew Singleton, Njideka Ulunma Okubadejo
BACKGROUND: An understanding of the genetic mechanisms underlying diseases in ancestrally diverse populations is an important step towards development of targeted treatments. Research in African and African admixed populations can enable mapping of complex traits, because of their genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. We aimed to do a comprehensive genome-wide assessment in African and African admixed individuals to better understand the genetic architecture of Parkinson's disease in these underserved populations...
November 2023: Lancet Neurology
https://read.qxmd.com/read/37573793/major-depressive-disorder-and-chronic-gastritis-a-bidirectional-two-sample-mendelian-randomization-study
#25
JOURNAL ARTICLE
Junlin Li, Xiuyun Chen, Mingyu Yin, Xin Lan, Lei Xie, Wenguan Huang, Minyi Luo, Ying Ai, Jinyang He
OBJECTIVE: Observational studies have posited a strong correlation between chronic gastritis (CG) and major depressive disorder (MDD), but the nature of this association remains uncertain, owing to the challenges of establishing the temporal sequence. The present study sought to elucidate the elusive relationship between CG and MDD by employing a bidirectional two-sample Mendelian randomization (MR) approach. METHODS: We extracted instrumental variants for MDD and CG from published genome-wide association study data, focusing on individuals of primarily European descent...
August 10, 2023: Journal of Psychosomatic Research
https://read.qxmd.com/read/37556136/association-of-genetically-predicted-insomnia-with-risk-of-sepsis-a-mendelian-randomization-study
#26
JOURNAL ARTICLE
Marianne S Thorkildsen, Lise T Gustad, Randi M Mohus, Stephen Burgess, Tom I L Nilsen, Jan K Damås, Tormod Rogne
IMPORTANCE: Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. To further understand the potential causal association between insomnia and sepsis risk, a 2-sample Mendelian randomization (MR) approach should be explored. OBJECTIVE: To evaluate whether genetically predicted insomnia is associated with risk of sepsis...
August 9, 2023: JAMA Psychiatry
https://read.qxmd.com/read/37553455/daily-briefing-23andme-dna-reveals-living-descendants-of-enslaved-people
#27
Flora Graham
No abstract text is available yet for this article.
August 7, 2023: Nature
https://read.qxmd.com/read/37541241/ethical-considerations-when-co-analyzing-ancient-dna-and-data-from-private-genetic-databases
#28
REVIEW
Éadaoin Harney, Kendra Sirak, Jakob Sedig, Steven Micheletti, Roslyn Curry, Samantha Ancona Esselmann, David Reich
Ancient DNA studies have begun to explore the possibility of identifying identical DNA segments shared between historical and living people. This research requires access to large genetic datasets to maximize the likelihood of identifying previously unknown, close genetic connections. Direct-to-consumer genetic testing companies, such as 23andMe, Inc., manage by far the largest and most diverse genetic databases that can be used for this purpose. It is therefore important to think carefully about guidelines for carrying out collaborations between researchers and such companies...
September 7, 2023: American Journal of Human Genetics
https://read.qxmd.com/read/37540821/causal-associations-between-prodromal-infection-and-neuromyelitis-optica-spectrum-disorder-a-mendelian-randomization-study
#29
JOURNAL ARTICLE
Liang Wang, Lei Zhou, Jingzi ZhangBao, Wenjuan Huang, Hongmei Tan, Yuxin Fan, Chuanzhen Lu, Jian Yu, Min Wang, Jiahong Lu, Chongbo Zhao, Tiansong Zhang, Chao Quan
BACKGROUND AND PURPOSE: Prodromal infections are associated with neuromyelitis optica spectrum disorder (NMOSD), but it remains unclear which type of infection has a causal association with NMOSD. We aimed to explore the causal associations between four herpesvirus infections (chickenpox, cold sores, mononucleosis and shingles) and NMOSD, as well as between other types of infections and NMOSD. METHODS: For data on infections, we used the genome-wide association study (GWAS) summary statistics from the 23andMe cohort...
August 4, 2023: European Journal of Neurology
https://read.qxmd.com/read/37537290/ancient-dna-reveals-the-living-descendants-of-enslaved-people-through-23andme
#30
Ewen Callaway
No abstract text is available yet for this article.
August 3, 2023: Nature
https://read.qxmd.com/read/37535739/the-genetic-legacy-of-african-americans-from-catoctin-furnace
#31
JOURNAL ARTICLE
Éadaoin Harney, Steven Micheletti, Karin S Bruwelheide, William A Freyman, Katarzyna Bryc, Ali Akbari, Ethan Jewett, Elizabeth Comer, Henry Louis Gates, Linda Heywood, John Thornton, Roslyn Curry, Samantha Ancona Esselmann, Kathryn G Barca, Jakob Sedig, Kendra Sirak, Iñigo Olalde, Nicole Adamski, Rebecca Bernardos, Nasreen Broomandkhoshbacht, Matthew Ferry, Lijun Qiu, Kristin Stewardson, J Noah Workman, Fatma Zalzala, Shop Mallick, Adam Micco, Matthew Mah, Zhao Zhang, Nadin Rohland, Joanna L Mountain, Douglas W Owsley, David Reich
Few African Americans have been able to trace family lineages back to ancestors who died before the 1870 United States Census, the first in which all Black people were listed by name. We analyzed 27 individuals from Maryland's Catoctin Furnace African American Cemetery (1774-1850), identifying 41,799 genetic relatives among consenting research participants in 23andMe, Inc.'s genetic database. One of the highest concentrations of close relatives is in Maryland, suggesting that descendants of the Catoctin individuals remain in the area...
August 4, 2023: Science
https://read.qxmd.com/read/37433877/author-correction-gwas-and-meta-analysis-identifies-49-genetic-variants-underlying-critical-covid-19
#32
Erola Pairo-Castineira, Konrad Rawlik, Andrew D Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A McConkey, Marie Zechner, Lucija Klaric, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D Russell, Tomas Malinauskas, Ryan Thwaites, Kirstie Morrice, Sean Keating, David Maslove, Alistair Nichol, Malcolm G Semple, Julian Knight, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J M Openshaw, Colin Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, José A Riancho, Augusto Rojas-Martinez, Pablo Lapunzina, Jian Yang, Chris P Ponting, James F Wilson, Veronique Vitart, Malak Abedalthagafi, Andre D Luchessi, Esteban J Parra, Raquel Cruz, Angel Carracedo, Angie Fawkes, Lee Murphy, Kathy Rowan, Alexandre C Pereira, Andy Law, Benjamin Fairfax, Sara Clohisey Hendry, J Kenneth Baillie
No abstract text is available yet for this article.
July 11, 2023: Nature
https://read.qxmd.com/read/37398408/genome-wide-association-identifies-novel-etiological-insights-associated-with-parkinson-s-disease-in-african-and-african-admixed-populations
#33
Mie Rizig, Sara Bandres-Ciga, Mary B Makarious, Oluwadamilola Ojo, Peter Wild Crea, Oladunni Abiodun, Kristin S Levine, Sani Abubakar, Charles Achoru, Dan Vitale, Olaleye Adeniji, Osigwe Agabi, Mathew J Koretsky, Uchechi Agulanna, Deborah A Hall, Rufus Akinyemi, Tao Xie, Mohammed Ali, Ejaz A Shamim, Ifeyinwa Ani-Osheku, Mahesh Padmanaban, Owotemu Arigbodi, David G Standaert, Abiodun Bello, Marissa Dean, Cyril Erameh, Inas Elsayed, Temitope Farombi, Olaitan Okunoye, Michael Fawale, Kimberley J Billingsley, Frank Imarhiagbe, Pilar Alvarez Jerez, Emmanuel Iwuozo, Breeana Baker, Morenikeji Komolafe, Laksh Malik, Paul Nwani, Kensuke Daida, Ernest Nwazor, Abigail Miano-Burkhardt, Yakub Nyandaiti, Zih-Hua Fang, Yahaya Obiabo, Jillian H Kluss, Olanike Odeniyi, Dena Hernandez, Francis Odiase, Nahid Tayebi, Francis Ojini, Ellen Sidranksy, Gerald Onwuegbuzie, Andrea M D'Souza, Godwin Osaigbovo, Bahafta Berhe, Nosakhare Osemwegie, Xylena Reed, Olajumoke Oshinaike, Hampton Leonard, Folajimi Otubogun, Chelsea X Alvarado, Shyngle Oyakhire, Simon Ozomma, Sarah Samuel, Funmilola Taiwo, Kolawole Wahab, Yusuf Zubair, Hirotaka Iwaki, Jonggeol Jeffrey Kim, Huw R Morris, John Hardy, Mike Nalls, Karl Heilbron, Lucy Norcliffe-Kaufmann, Cornelis Blauwendraat, Henry Houlden, Andrew Singleton, Njideka Okubadejo
BACKGROUND: Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards the realization of the global application of precision medicine. The African and African admixed populations enable mapping of complex traits given their greater levels of genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. METHODS: Here we perform a comprehensive genome-wide assessment of Parkinson's disease (PD) in 197,918 individuals (1,488 cases; 196,430 controls) of African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding and structural genetic variation and polygenic risk profiling...
May 7, 2023: medRxiv
https://read.qxmd.com/read/37386247/large-scale-multitrait-genome-wide-association-analyses-identify-hundreds-of-glaucoma-risk-loci
#34
JOURNAL ARTICLE
Xikun Han, Puya Gharahkhani, Andrew R Hamel, Jue Sheng Ong, Miguel E Rentería, Puja Mehta, Xianjun Dong, Francesca Pasutto, Christopher Hammond, Terri L Young, Pirro Hysi, Andrew J Lotery, Eric Jorgenson, Hélène Choquet, Michael Hauser, Jessica N Cooke Bailey, Toru Nakazawa, Masato Akiyama, Yukihiro Shiga, Zachary L Fuller, Xin Wang, Alex W Hewitt, Jamie E Craig, Louis R Pasquale, David A Mackey, Janey L Wiggs, Anthony P Khawaja, Ayellet V Segrè, Stuart MacGregor
Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous genome-wide association studies have identified over 100 loci for the most common form, primary open-angle glaucoma. Two key glaucoma-associated traits also show high heritability: intraocular pressure and optic nerve head excavation damage quantified as the vertical cup-to-disc ratio. Here, since much of glaucoma heritability remains unexplained, we conducted a large-scale multitrait genome-wide association study in participants of European ancestry combining primary open-angle glaucoma and its two associated traits (total sample size over 600,000) to substantially improve genetic discovery power (263 loci)...
June 29, 2023: Nature Genetics
https://read.qxmd.com/read/37288324/23me-00610-a-genetically-informed-first-in-class-antibody-targeting-cd200r1-to-enhance-antitumor-t-cell-function
#35
JOURNAL ARTICLE
Jill Fenaux, Xin Fang, Yao-Ming Huang, Cristina Melero, Caroline Bonnans, Earth Light Lowe, Tiziana Palumbo, Cecilia Lay, Zuoan Yi, Aileen Zhou, Mauro Poggio, Wei-Jen Chung, Sophia R Majeed, Dylan Glatt, Alice Chen, Maike Schmidt, Clarissa C Lee
Immune checkpoint inhibition (ICI) has revolutionized cancer treatment; however, only a subset of patients benefit long term. Therefore, methods for identification of novel checkpoint targets and development of therapeutic interventions against them remain a critical challenge. Analysis of human genetics has the potential to inform more successful drug target discovery. We used genome-wide association studies of the 23andMe genetic and health survey database to identify an immuno-oncology signature in which genetic variants are associated with opposing effects on risk for cancer and immune diseases...
2023: Oncoimmunology
https://read.qxmd.com/read/37198478/gwas-and-meta-analysis-identifies-49-genetic-variants-underlying-critical-covid-19
#36
JOURNAL ARTICLE
Erola Pairo-Castineira, Konrad Rawlik, Andrew D Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A McConkey, Marie Zechner, Lucija Klaric, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D Russell, Tomas Malinauskas, Ryan Thwaites, Kirstie Morrice, Sean Keating, David Maslove, Alistair Nichol, Malcolm G Semple, Julian Knight, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J M Openshaw, Colin Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, José A Riancho, Augusto Rojas-Martinez, Pablo Lapunzina, Jian Yang, Chris P Ponting, James F Wilson, Veronique Vitart, Malak Abedalthagafi, Andre D Luchessi, Esteban J Parra, Raquel Cruz, Angel Carracedo, Angie Fawkes, Lee Murphy, Kathy Rowan, Alexandre C Pereira, Andy Law, Benjamin Fairfax, Sara Clohisey Hendry, J Kenneth Baillie
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2 . Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3 . Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases)...
May 2023: Nature
https://read.qxmd.com/read/37173343/cadm2-is-implicated-in-impulsive-personality-and-numerous-other-traits-by-genome-and-phenome-wide-association-studies-in-humans-and-mice
#37
JOURNAL ARTICLE
Sandra Sanchez-Roige, Mariela V Jennings, Hayley H A Thorpe, Jazlene E Mallari, Lieke C van der Werf, Sevim B Bianchi, Yuye Huang, Calvin Lee, Travis T Mallard, Samuel A Barnes, Jin Yi Wu, Amanda M Barkley-Levenson, Ely C Boussaty, Cedric E Snethlage, Danielle Schafer, Zeljana Babic, Boyer D Winters, Katherine E Watters, Thomas Biederer, James Mackillop, David N Stephens, Sarah L Elson, Pierre Fontanillas, Jibran Y Khokhar, Jared W Young, Abraham A Palmer
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) of eight impulsive personality traits from the Barratt Impulsiveness Scale and the short UPPS-P Impulsive Personality Scale (N = 123,509-133,517 23andMe research participants of European ancestry), and a measure of Drug Experimentation (N = 130,684)...
May 12, 2023: Translational Psychiatry
https://read.qxmd.com/read/37164954/shared-molecular-genetic-factors-influence-subcortical-brain-morphometry-and-parkinson-s-disease-risk
#38
JOURNAL ARTICLE
Luis M García-Marín, Paula Reyes-Pérez, Santiago Diaz-Torres, Alejandra Medina-Rivera, Nicholas G Martin, Brittany L Mitchell, Miguel E Rentería
Parkinson's disease (PD) is a late-onset and genetically complex neurodegenerative disorder. Here we sought to identify genes and molecular pathways underlying the associations between PD and the volume of ten brain structures measured through magnetic resonance imaging (MRI) scans. We leveraged genome-wide genetic data from several cohorts, including the International Parkinson's Disease Genomics Consortium (IPDG), the UK Biobank, the Adolescent Brain Cognitive Development (ABCD) study, the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), the Enhancing Neuroimaging Genetics through Meta-Analyses (ENIGMA), and 23andMe...
May 10, 2023: NPJ Parkinson's Disease
https://read.qxmd.com/read/37143736/genetically-predicted-alterations-in-thyroid-function-are-associated-with-the-risk-of-benign-prostatic-disease
#39
JOURNAL ARTICLE
Yan Huang, Cheng Chen, Wanqing Zhou, Qian Zhang, Yanfei Zhao, Dehao He, Zhi Ye, Pingping Xia
BACKGROUND: Benign prostatic diseases (BPDs), such as benign prostate hyperplasia (BPH) and prostatitis, harm the quality of life of affected patients. However, observational studies exploring the association between thyroid function and BPDs have hitherto yielded inconsistent results. In this study, we explored whether there is a causal genetic association between them using Mendelian randomization (MR) analysis. METHODS: We used publicly available summary statistics from the Thyroidomics Consortium and 23andMe on thyrotropin (TSH; 54,288 participants), thyroxine [free tetraiodothyronine (FT4); 49,269 participants], subclinical hypothyroidism (3,440 cases and 49,983 controls), overt hypothyroidism (8,000 cases and 117,000 controls), and subclinical hyperthyroidism (1,840 cases and 49,983 controls) to screen for instrumental variables of thyroid function...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37090648/me-bayes-sl-enhanced-bayesian-polygenic-risk-prediction-leveraging-information-across-multiple-ancestry-groups
#40
Jin Jin, Jianan Zhan, Jingning Zhang, Ruzhang Zhao, Jared Oâ Connell, Yunxuan Jiang, Steven Buyske, Christopher Gignoux, Christopher Haiman, Eimear E Kenny, Charles Kooperberg, Kari North, Bertram L Koelsch, Genevieve Wojcik, Haoyu Zhang, Nilanjan Chatterjee
Polygenic risk scores (PRS) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists a substantial performance gap across different populations. We propose ME-Bayes SL, a method for ancestry-specific polygenic prediction that borrows information in the summary statistics from genome-wide association studies (GWAS) across multiple ancestry groups. ME-Bayes SL conducts Bayesian hierarchical modeling under a multivariate spike-and-slab model for effect-size distribution and incorporates an ensemble learning step to combine information across different tuning parameter settings and ancestry groups...
April 13, 2023: bioRxiv
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