Mie Rizig, Sara Bandres-Ciga, Mary B Makarious, Oluwadamilola Ojo, Peter Wild Crea, Oladunni Abiodun, Kristin S Levine, Sani Abubakar, Charles Achoru, Dan Vitale, Olaleye Adeniji, Osigwe Agabi, Mathew J Koretsky, Uchechi Agulanna, Deborah A Hall, Rufus Akinyemi, Tao Xie, Mohammed Ali, Ejaz A Shamim, Ifeyinwa Ani-Osheku, Mahesh Padmanaban, Owotemu Arigbodi, David G Standaert, Abiodun Bello, Marissa Dean, Cyril Erameh, Inas Elsayed, Temitope Farombi, Olaitan Okunoye, Michael Fawale, Kimberley J Billingsley, Frank Imarhiagbe, Pilar Alvarez Jerez, Emmanuel Iwuozo, Breeana Baker, Morenikeji Komolafe, Laksh Malik, Paul Nwani, Kensuke Daida, Ernest Nwazor, Abigail Miano-Burkhardt, Yakub Nyandaiti, Zih-Hua Fang, Yahaya Obiabo, Jillian H Kluss, Olanike Odeniyi, Dena Hernandez, Francis Odiase, Nahid Tayebi, Francis Ojini, Ellen Sidranksy, Gerald Onwuegbuzie, Andrea M D'Souza, Godwin Osaigbovo, Bahafta Berhe, Nosakhare Osemwegie, Xylena Reed, Olajumoke Oshinaike, Hampton Leonard, Folajimi Otubogun, Chelsea X Alvarado, Shyngle Oyakhire, Simon Ozomma, Sarah Samuel, Funmilola Taiwo, Kolawole Wahab, Yusuf Zubair, Hirotaka Iwaki, Jonggeol Jeffrey Kim, Huw R Morris, John Hardy, Mike Nalls, Karl Heilbron, Lucy Norcliffe-Kaufmann, Cornelis Blauwendraat, Henry Houlden, Andrew Singleton, Njideka Okubadejo
BACKGROUND: Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards the realization of the global application of precision medicine. The African and African admixed populations enable mapping of complex traits given their greater levels of genetic diversity, extensive population substructure, and distinct linkage disequilibrium patterns. METHODS: Here we perform a comprehensive genome-wide assessment of Parkinson's disease (PD) in 197,918 individuals (1,488 cases; 196,430 controls) of African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding and structural genetic variation and polygenic risk profiling...
May 7, 2023: medRxiv