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https://www.readbyqxmd.com/read/29730182/face-content-and-construct-validations-of-endoscopic-needle-injection-simulator-for-transurethral-bulking-agent-in-treatment-of-stress-urinary-incontinence
#1
Bilal Farhan, Tandis Soltani, Rebecca Do, Claudia Perez, Hanul Choi, Gamal Ghoniem
INTRODUCTION AND OBJECTIVES: Endoscopic injection of urethral bulking agents is an office procedure that is used to treat stress urinary incontinence secondary to internal sphincteric deficiency. Validation studies important part of simulator evaluation and is considered important step to establish the effectiveness of simulation-based training. The endoscopic needle injection (ENI) simulator has not been formally validated, although it has been used widely at University of California, Irvine...
May 2, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29714050/maternal-metabolomic-profile-and-fetal-programming-of-offspring-adiposity-identification-of-potentially-protective-lipid-metabolites
#2
Christian Hellmuth, Karen L Lindsay, Olaf Uhl, Claudia Buss, Pathik D Wadhwa, Berthold Koletzko, Sonja Entringer
SCOPE: The fetal programming paradigm posits that the origins of obesity can be traced, in part, to the intrauterine period of life. However, the mechanisms underlying fetal programming are not well understood, and few studies have measured offspring adiposity in the neonatal period. The aim of this study was to identify maternal metabolites, and their determinants, that are associated with neonatal adiposity. METHODS AND RESULTS: We applied a targeted metabolomics approach to analyze plasma samples collected across gestation from a well-characterized cohort of 253 pregnant women participating in a prospective study at the University of California, Irvine...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29712523/strategic-hospital-partnerships-improved-access-to-care-and-increased-epilepsy-surgical-volume
#3
Sumeet Vadera, Alvin Y Chan, Lilit Mnatsankanyan, Mona Sazgar, Indranil Sen-Gupta, Jack Lin, Frank P K Hsu
OBJECTIVE Surgical treatment of patients with medically refractory focal epilepsy is underutilized. Patients may lack access to surgically proficient centers. The University of California, Irvine (UCI) entered strategic partnerships with 2 epilepsy centers with limited surgical capabilities. A formal memorandum of understanding (MOU) was created to provide epilepsy surgery to patients from these centers. METHODS The authors analyzed UCI surgical and financial data associated with patients undergoing epilepsy surgery between September 2012 and June 2016, before and after institution of the MOU...
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29706283/a-unique-degree-program-for-pre-pharmacy-education-an-undergraduate-degree-in-pharmaceutical-sciences
#4
Mahtab Jafari
BACKGROUND AND PURPOSE: Within the coming decade, the demand for well-trained pharmacists is expected to only increase, especially with the aging of the United States (US) population. EDUCATIONAL ACTIVITY AND SETTING: To help fill this growing demand, the University of California, Irvine (UCI) aims to offer a unique pre-pharmacy degree program and has developed a Bachelor of Science (BS) degree in Pharmaceutical Sciences to help achieve this goal. In this commentary, we share our experience with our curriculum and highlight its features in an effort to encourage other institutions to enhance the learning experience of their pre-pharmacy students...
February 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29692863/multiclass-classification-of-cardiac-arrhythmia-using-improved-feature-selection-and-svm-invariants
#5
Anam Mustaqeem, Syed Muhammad Anwar, Muahammad Majid
Arrhythmia is considered a life-threatening disease causing serious health issues in patients, when left untreated. An early diagnosis of arrhythmias would be helpful in saving lives. This study is conducted to classify patients into one of the sixteen subclasses, among which one class represents absence of disease and the other fifteen classes represent electrocardiogram records of various subtypes of arrhythmias. The research is carried out on the dataset taken from the University of California at Irvine Machine Learning Data Repository...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29579207/implementation-of-a-human-papillomavirus-screen-and-treat-model-in-mwanza-tanzania-training-local-healthcare-workers-for-sustainable-impact
#6
Megan Bernstein, Anjali Hari, Sahil Aggarwal, Debora Lee, Allison Farfel, Priya Patel, Kaavya Raman, Shella Raja, Reece Fenning, Mark Lieber, William Minteer, Sean Denny, Maureen Ries
Background: The purpose of this study is to evaluate the development of a 1-wk screening campaign and efforts towards the implementation of a sustainable system that addresses cervical cancer in Mwanza, Tanzania with a screen-and-treat model utilizing visual inspection of the cervix with acetic acid (VIA) and cryotherapy. Methods: In partnership with CureCervicalCancer (CCC), a non-profit organization based in Los Angeles, CA, USA, 11 medical students at the University of California, Irvine School of Medicine established a model for sustainable human papillomavirus screening practices in Mwanza, Tanzania...
March 22, 2018: International Health
https://www.readbyqxmd.com/read/29196430/aligning-practice-to-policies-changing-the-culture-to-recognize-and-reward-teaching-at-research-universities
#7
Michael Dennin, Zachary D Schultz, Andrew Feig, Noah Finkelstein, Andrea Follmer Greenhoot, Michael Hildreth, Adam K Leibovich, James D Martin, Mark B Moldwin, Diane K O'Dowd, Lynmarie A Posey, Tobin L Smith, Emily R Miller
Recent calls for improvement in undergraduate education within STEM (science, technology, engineering, and mathematics) disciplines are hampered by the methods used to evaluate teaching effectiveness. Faculty members at research universities are commonly assessed and promoted mainly on the basis of research success. To improve the quality of undergraduate teaching across all disciplines, not only STEM fields, requires creating an environment wherein continuous improvement of teaching is valued, assessed, and rewarded at various stages of a faculty member's career...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29136390/assurance-of-myeloid-growth-factor-administration-in-an-infusion-center-pilot-quality-improvement-initiative
#8
Pamela Maree Ramirez, Barry Peterson, Christine Holtshopple, Kristina Borja, Vincent Torres, Lucille Valdivia-Peppers, Julio Harriague, Melanie D Joe
PURPOSE: Four incident reports involving missed doses of myeloid growth factors (MGFs) triggered the need for an outcome-driven initiative. From March 1, 2015, to February 29, 2016, at University of California Irvine Health Chao Infusion Center, 116 of 3,300 MGF doses were missed (3.52%), including pegfilgrastim, filgrastim, and sargramostim. We hypothesized that with the application of Lean Six Sigma methodology, we would achieve our primary objective of reducing the number of missed MGF doses to < 0...
December 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29082321/expert-panel-on-understanding-cannabis-medicine-society-government
#9
Kyle Kazan, Daniele Piomelli, Dana Rohrabacher, Lori Ajax
On May 5, 2017, the Department of Anatomy and Neurobiology of the University of California Irvine convened an expert panel to discuss issues related to cannabis at the interface between medical science, society and government. The expert panel included Dr. Daniele Piomelli, U.S. Representative Dana Rohrabacher, Lori Ajax, and was moderated by Kyle Kazan.
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29060691/wrapper-method-for-feature-selection-to-classify-cardiac-arrhythmia
#10
Anam Mustaqeem, Syed Muhammad Anwar, Muhammad Majid, Abdul Rashid Khan
Efficient monitoring of cardiac patients can save tremendous amount of lives. Cardiac disease prediction and classification has gained utmost significance in this regard during the past few years. This paper presents a predictive model for classification of arrhythmias. The model works by selecting best features using wrapper algorithm around random forest, followed by implementing various machine learning classifiers on the selected features. Cardiac arrhythmia dataset from University of California, Irvine (UCI) machine learning repository has been used for the experimental purpose...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28956226/evolutionary-and-neural-computing-based-decision-support-system-for-disease-diagnosis-from-clinical-data-sets-in-medical-practice
#11
M Sudha
As a recent trend, various computational intelligence and machine learning approaches have been used for mining inferences hidden in the large clinical databases to assist the clinician in strategic decision making. In any target data the irrelevant information may be detrimental, causing confusion for the mining algorithm and degrades the prediction outcome. To address this issue, this study attempts to identify an intelligent approach to assist disease diagnostic procedure using an optimal set of attributes instead of all attributes present in the clinical data set...
September 27, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28910806/warfarin-use-and-increased-mortality-in-end-stage-renal-disease
#12
Mark C Lin, Elani Streja, Melissa Soohoo, Medhat Hanna, Javad Savoj, Kamyar Kalantar-Zadeh, Wei Ling Lau
BACKGROUND: Controversy exists regarding the benefits and risks of warfarin therapy in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. In this study, we assessed mortality and cardiovascular outcomes associated with warfarin treatment in patients with stages 3-5 CKD and ESRD admitted to the University of California-Irvine Medical Center. METHODS: In a retrospective matched cohort study, we identified 59 adult patients with stages 3-6 CKD initiated on warfarin during the period 2011-2013, and 144 patients with stages 3-6 CKD who had indications for anticoagulation therapy but were not initiated on warfarin...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28905236/diagnosis-of-coronary-artery-disease-using-an-efficient-hash-table-based-closed-frequent-itemsets-mining
#13
Ramesh Dhanaseelan, M Jeya Sutha
This paper proposes an efficient hash table based closed frequent itemsets (HCFI) mining algorithm to envisage coronary artery disease early. HCFI algorithm generates closed frequent itemsets efficiently by performing intersection operation on transaction id's of itemset without considering the name of item/itemset. The employed hash table reduces search efficiency to O(1) or constant time. HCFI algorithm is applied on the UCI (University of California, Irvine) Cleveland dataset, a biological database of cardiovascular disease to generate closed frequent itemsets on the dataset...
May 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28835251/noise-assisted-multivariate-empirical-mode-decomposition-for-multichannel-emg-signals
#14
Yi Zhang, Peng Xu, Peiyang Li, Keyi Duan, Yuexin Wen, Qin Yang, Tao Zhang, Dezhong Yao
BACKGROUND: Ensemble Empirical Mode Decomposition (EEMD) has been popularised for single-channel Electromyography (EMG) signal processing as it can effectively extract the temporal information of the EMG time series. However, few papers examine the temporal and spatial characteristics across multiple muscle groups in relation to multichannel EMG signals. EXPERIMENT: The experimental data was obtained from the Center for Machine Learning and Intelligent Systems, University of California Irvine (UCI)...
August 23, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28828193/strategies-for-overcoming-anti-tumor-necrosis-factor-drug-antibodies-in-inflammatory-bowel-disease-case-series-and-review-of-literature
#15
EDITORIAL
Mansi M Kothari, Douglas L Nguyen, Nimisha K Parekh
Anti-tumor necrosis factor (TNF) biologics are currently amongst the most widely used and efficacious therapies for inflammatory bowel disease (IBD). The development of therapeutic drug monitoring for infliximab and adalimumab has allowed for measurement of drug levels and antidrug antibodies. This information can allow for manipulation of drug therapy and prediction of response. It has been shown that therapeutic anti-TNF drug levels are associated with maintenance of remission, and development of antidrug antibodies is predictive of loss of response...
August 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28600264/generalized-self-organizing-maps-for-automatic-determination-of-the-number-of-clusters-and-their-multiprototypes-in-cluster-analysis
#16
Marian B Gorzalczany, Filip Rudzinski
This paper presents a generalization of self-organizing maps with 1-D neighborhoods (neuron chains) that can be effectively applied to complex cluster analysis problems. The essence of the generalization consists in introducing mechanisms that allow the neuron chain--during learning--to disconnect into subchains, to reconnect some of the subchains again, and to dynamically regulate the overall number of neurons in the system. These features enable the network--working in a fully unsupervised way (i.e., using unlabeled data without a predefined number of clusters)--to automatically generate collections of multiprototypes that are able to represent a broad range of clusters in data sets...
June 7, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28512422/acute-onset-ocular-hypotony-after-coronary-artery-bypass-surgery
#17
Sarah Farukhi Ahmed, Audrey Xi Tai, Mason Schmutz, John Combs, Sameh Mosaed
IMPORTANCE: The purpose of this case report is to evaluate risk factors associated with post-coronary artery bypass graft (CABG) ocular hypotony compared to post-CABG ischemic optic neuropathy. OBSERVATIONS: The patient described here is a single case at the University of California, Irvine Medical Center, from July 2016. This case demonstrates the rare incidence of acute post-CABG ocular hypotony and vision loss in a patient with prior history of optic atrophy...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28398523/transitions-in-pregnancy-planning-in-women-recruited-for-a-large-prospective-cohort-study
#18
COMPARATIVE STUDY
U Luderer, T Li, J P Fine, R F Hamman, J B Stanford, D Baker
STUDY QUESTION: Do the rates at which women transition among different intensities of pregnancy planning vary with age, marital status and race/ethnicity? SUMMARY ANSWER: Rates of transition from low or moderate pregnancy probability groups (PPGs) to higher PPGs vary by age, marital status and race/ethnicity. WHAT IS KNOWN ALREADY: The design of prospective studies of the effects of pre- and peri-conception exposures on fecundity, pregnancy and children's health is challenging because at any specific time only a small percentage of reproductive age women is attempting to conceive...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28295607/incremental-hemodialysis-the-university-of-california-irvine-experience
#19
Mehrdad Ghahremani-Ghajar, Vanessa Rojas-Bautista, Wei-Ling Lau, Madeleine Pahl, Miguel Hernandez, Anna Jin, Uttam Reddy, Jason Chou, Yoshitsugu Obi, Kamyar Kalantar-Zadeh, Connie M Rhee
Incremental hemodialysis has been examined as a viable hemodialysis regimen for selected end-stage renal disease (ESRD) patients. Preservation of residual kidney function (RKF) has been the driving impetus for this approach given its benefits upon the survival and quality of life of dialysis patients. While clinical practice guidelines recommend an incremental start of dialysis in peritoneal dialysis patients with substantial RKF, there remains little guidance with respect to incremental hemodialysis as an initial renal replacement therapy regimen...
May 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28185763/bariatric-surgery-attenuates-colitis-in-an-obese-murine-model
#20
Shiri Li, Alessio Vinci, Judith Behnsen, Chunmei Cheng, Stefan Jellbauer, Manuela Raffatellu, Kyle M Sousa, Robert Edwards, Ninh T Nguyen, Michael J Stamos, Alessio Pigazzi
BACKGROUND: Obesity and inflammatory bowel disease (IBD) represent chronic inflammatory conditions. Bariatric surgery improves some obesity-related co-morbidities, but the effects of bariatric surgery on IBD have not been well studied. OBJECTIVES: To examine if bariatric surgery may attenuate colitis in an obese murine model of IBD and study the mechanisms underlying the postsurgical amelioration of intestinal inflammation. SETTING: University of California Irvine, Department of Surgery and Microbiology laboratories...
April 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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