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Pharmacokinetiics

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https://www.readbyqxmd.com/read/19764333/-anti-viral-effects-of-tankejing-preparations-against-influenza-virus-a
#1
Yong-Nan Jiang, Hong-Ying Mo
OBJECTIVE: To investigate the anti-viral effects of Tankejing preparations (including solutions, dry power inhalation and powder) against influenza virus A in vitro and the relationship between its anti-viral effect and preparations. METHODS: The inhibitive effect of different drug-added ways of Tankejing extracts against human influenza virus A (H3N2) in vitro were assayed by crystallized purple staining method with ribavirin as positive reference drug. Then we compared the anti-viral actions of different kinds of Tankejing preparations...
June 2009: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/10626090/a-review-of-the-antiepileptic-drug-tiagabine
#2
REVIEW
S C Schachter
Tiagabine (TGB), a recently approved antiepileptic drug (AED), has a specific mechanism of action that is unique among AEDs. A potent AED with linear, predictable pharmacokineties, it inhibits gamma-aminobutyric acid (GABA) reuptake into neurons and glia. Tiagabine does not have any clinically relevant effects on hepatic metabolism or on serum concentrations of other AEDs, nor does it interact with commonly used non-AEDs. The most common side effects of TGB in controlled studies are dizziness, asthenia, somnolence, accidental injury, infection, headache, nausea, and nervousness...
November 1999: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/35329/pharmacokinetis-of-alpha-and-beta-isomers-of-racemic-endosulfan-following-intravenous-administration-in-rabbits
#3
P K Gupta, M Ehrnebo
The pharmacokinetics of the alpha- and beta-isomers of endosulfan in rabbits was investigated following intravenous injection. Endosulfan (2 mg/kg) was given as a mixture of the two isomers in the ratio 70:30. The plasma concentration-time data for alpha-endosulfan was best fitted to the three-compartment model with a terminal slope half-life of 235 +/- 168 (SD; N = 6) hr. The data for beta-endosulfan was adequately described by the two-compartment model, the corresponding half-life was 5.97 +/- 2.41 hr. The total distribution volumes during the terminal slopes were, however, similar for alpha- and beta-endosulfan (675 +/- 246 and 565 +/- 126 ml/kg, respectively)...
January 1979: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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