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https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#1
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29677683/application-of-solid-phase-microextraction-followed-by-liquid-chromatography-mass-spectrometry-in-the-determination-of-antibiotic-drugs-and-their-metabolites-in-human-whole-blood-and-tissue-samples
#2
Malgorzata Szultka-Mlynska, Pawel Pomastowski, Boguslaw Buszewski
A sensitive, rapid and specific analytical method using high performance liquid chromatography coupled with mass spectrometry (HPLC-QqQ-MS) was developed to determine selected antibiotic drugs and their metabolites (amoxicillin, cefotaxime, ciprofloxacin, clindamycin and metronidazole; amoxycilloic acid, 4-hydroxyphenyl glycyl amoxicillin, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, ciprofloxacin N-oxide, N-demethylclindamycin, clindamycin sulfoxide, and hydroxy metronidazole) in human whole blood and vascularized tissue after single oral administration...
April 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29677676/assessing-the-geomorphological-vulnerability-of-arid-beach-dune-systems
#3
Carolina Peña-Alonso, Juan B Gallego-Fernández, Luis Hernández-Calvento, Antonio I Hernández-Cordero, Eduard Ariza
In this study, an arid dune vulnerability index (ADVI) is developed using a system of indicators to evaluate the geomorphological vulnerability of beach-dune systems of arid regions. The indicators are comprised of three analytical dimensions (susceptibility, exposure and resilience) and their corresponding sub-indices and variables and were assessed for eleven sites located in four aeolian sedimentary systems of the Canary archipelago (Spain). The selected sites have varying geomorphological characteristics, vegetation types, marine and wind conditions and human pressure degrees, and have seen different trends in their geomorphological evolution since 1960...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677603/the-comparative-evidence-basis-for-the-efficacy-of-second-generation-antidepressants-in-the-treatment-of-depression-in-the-us-a-bayesian-meta-analysis-of-food-and-drug-administration-reviews
#4
Rei Monden, Annelieke M Roest, Don van Ravenzwaaij, Eric-Jan Wagenmakers, Richard Morey, Klaas J Wardenaar, Peter de Jonge
BACKGROUND: Studies have shown similar efficacy of different antidepressants in the treatment of depression. METHOD: Data of phase-2 and -3 clinical-trials for 16 antidepressants (levomilnacipran, desvenlafaxine, duloxetine, venlafaxine, paroxetine, escitalopram, vortioxetine, mirtazapine, venlafaxine XR, sertraline, fluoxetine, citalopram, paroxetine CR, nefazodone, bupropion, vilazodone), approved by the FDA for the treatment of depression between 1987 and 2016, were extracted from the FDA reviews that were used to evaluate efficacy prior to marketing approval, which are less liable to reporting biases...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29677556/prenatal-exposure-to-polychlorinated-biphenyls-and-fetal-growth-in-british-girls
#5
Jill F Patel, Terryl J Hartman, Andreas Sjodin, Kate Northstone, Ethel V Taylor
Polychlorinated biphenyls (PCBs) are synthetic chemicals that bioaccumulate in the food chain. PCBs were used primarily for industrial applications due to their insulating and fire retardant properties, but were banned in the 1970s in the United States and in the 1980s in the United Kingdom, as adverse health effects following exposure were identified. Previous studies of populations with high PCB exposure have reported inverse associations with birth weight and gestational length. Birth weight is a powerful predictor of infant survival, and low birth weight can predispose infants to chronic conditions in adult life such as diabetes and cardiovascular diseases...
April 17, 2018: Environment International
https://www.readbyqxmd.com/read/29677528/low-arsenic-bioaccessibility-by-fixation-in-nanostructured-iron-hydr-oxides-quantitative-identification-of-as-bearing-phases
#6
Virginia S T Ciminelli, Daphne C Antônio, Claudia L Caldeira, Erico T F Freitas, Itamar Daniel Delbem, Marcus M Fernandes, Massimo Gasparon, Jack C Ng
A new analytical protocol was developed to provide quantitative, single-particle identification of arsenic in heterogeneous nanoscale mineral phases in soil samples, with a view to establishing its potential risk to human health. Microscopic techniques enabled quantitative, single-particle identification of As-bearing phases in twenty soil samples collected in a gold mining district with arsenic concentrations in range of 8 to 6354 mg kg-1 . Arsenic is primarily observed in association with iron (hydr) oxides in fine intergrowth with phyllosilicates...
March 29, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29677496/binding-of-p-mercaptobenzoic-acid-and-adenine-to-gold-coated-electroless-etched-silicon-nanowires-studied-by-surface-enhanced-raman-scattering
#7
Vlasta Mohaček-Grošev, Hrvoje Gebavi, Alois Bonifacio, Valter Sergo, Marko Daković, Danica Bajuk-Bogdanović
Modern diagnostic tools ever aim to reduce the amount of analyte and the time needed for obtaining the result. Surface-enhanced Raman spectroscopy is a method that could satisfy both of these requirements, provided that for each analyte an adequate substrate is found. Here we demonstrate the ability of gold-sputtered silicon nanowires (SiNW) to bind p-mercaptobenzoic acid in 10-3 , 10-4 and 10-5 M and adenine in 30 and 100μM concentrations. Based on the normal mode analysis, presented here for the first time, the binding of p-mercaptobenzoic acid is deduced...
April 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29677452/vitreous-levels-of-luteinizing-hormone-and-vegf-are-strongly-correlated-in-healthy-mammalian-eyes
#8
Tammy Z Movsas, Robert Sigler, Arivalagan Muthusamy
Purpose/Aim: Luteinizing hormone (LH) is known to function as a key regulator of VEGF expression in reproductive organs. In recent years, LH has also been detected in human vitreous and LH receptors have been identified in human retina. This study was aimed to investigate a potential correlation between LH and VEGF levels in healthy mammalian eyes to provide supporting evidence of LH's potential involvement in intraocular VEGF regulation. METHODS: 18 bovine and 30 porcine eyes were procured from an abattoire and VEGF and LH levels were measured in the vitreous extracted from these eyes by commercially-available bovine & porcine ELISA assay kits...
April 20, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29677445/new-amphiphilic-composite-for-preparing-efficient-coated-potassium-fertilizers-for-top-dressing-fertilization-of-annual-crops
#9
Oscar Urrutia, Javier Erro, Andre Vinicius Zabini, Kent Hoshiba, Anne Francoise Blandin, Roberto Baigorri, Manuel Martin-Pastor, Yves Alis, Jean-Claude Yvin, José María García-Mina
This study describes the efficiency of a new coating material for preparing granulated potassium-fertilizers with a potassium release to the soil solution sensitive to rainfall intensity. The composite is prepared by reaction of an alkyd-resin with cement in the absence of water. The complementary use of diverse analytical techniques showed that the presence of the cement fraction induced alkyd resin reticulation and gradual cement-resin hardening. Scanning electron microscopy revealed the formation of micro and nanopores within cement-clusters, whose water permeability is affected by the resin reticulation and amphiphilic character...
April 20, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29677208/modeling-the-dynamics-and-kinetics-of-hiv-1-gag-during-viral-assembly
#10
Michael D Tomasini, Daniel S Johnson, Joshua S Mincer, Sanford M Simon
We report a computational model for the assembly of HIV-1 Gag into immature viral particles at the plasma membrane. To reproduce experimental structural and kinetic properties of assembly, a process occurring on the order of minutes, a coarse-grained representation consisting of a single particle per Gag molecule is developed. The model uses information relating the functional interfaces implicated in Gag assembly, results from cryo electron-tomography, and biophysical measurements from fluorescence microscopy, such as the dynamics of Gag assembly at single virions...
2018: PloS One
https://www.readbyqxmd.com/read/29677179/knowledge-of-the-guarani-language-in-medical-students-at-a-university-hospital-in-paraguay
#11
Hassel Jimmy Jiménez, Lorena Delgadillo, Ana Campuzano de Rolon, Diana Jiménez, Angélica de Samudio, Adriana Agüero, César Radice, Gustavo Jiménez-Britez
INTRODUCTION: Paraguay is a bilingual country and knowledge of the guarani language is an important communication tool for the doctor- patient relationship. OBJECTIVE: To determine the degree of and the factors that influence the knowledge of the Guaraní language in medical students at a University Hospital in Paraguay. METHODS: Observational, cross-sectional, analytical study in which an anonymous questionnaire was applied to the final year medical students of a University Hospital of Paraguay...
April 10, 2018: Medwave
https://www.readbyqxmd.com/read/29677173/what-does-this-mutation-mean-the-tools-and-pitfalls-of-variant-interpretation-in-lymphoid-malignancies
#12
REVIEW
Guillermin Yann, Lopez Jonathan, Chabane Kaddour, Hayette Sandrine, Bardel Claire, Salles Gilles, Sujobert Pierre, Huet Sarah
High throughput sequencing (HTS) is increasingly important in determining cancer diagnoses, with subsequent prognostic and therapeutic implications. The biology of cancer is becoming increasingly deciphered and it is clear that therapy needs to be individually tailored. Whilst translational research plays an important role in lymphoid malignancies, few guidelines exist to guide biologists and routine laboratories through this constantly evolving field. In this article, we review the challenges of interpreting HTS in lymphoid malignancies and provide a toolkit to interpret single nucleotide variants obtained from HTS...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29677107/imprinted-oxide-and-mip-oxide-hybrid-nanomaterials-for-chemical-sensors-%C3%A2
#13
REVIEW
Adeel Afzal, Franz L Dickert
The oxides of transition, post-transition and rare-earth metals have a long history of robust and fast responsive recognition elements for electronic, optical, and gravimetric devices. A wide range of applications successfully utilized pristine or doped metal oxides and polymer-oxide hybrids as nanostructured recognition elements for the detection of biologically relevant molecules, harmful organic substances, and drugs as well as for the investigative process control applications. An overview of the selected recognition applications of molecularly imprinted sol-gel phases, metal oxides and hybrid nanomaterials composed of molecularly imprinted polymers (MIP) and metal oxides is presented herein...
April 20, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29676901/polar-imperfections-in-amino-acid-crystals-design-structure-and-emerging-functionalities
#14
Elena Meirzadeh, Isabelle Weissbuch, David Ehre, Meir Lahav, Igor Lubomirsky
Crystals are physical arrays delineated by polar surfaces and often contain imperfections of a polar nature. Understanding the structure of such defects on the molecular level is of topical importance since they strongly affect the macroscopic properties of materials. Moreover, polar imperfections in crystals can be created intentionally and specifically designed by doping nonpolar crystals with "tailor-made" additives as dopants, since their incorporation generally takes place in a polar mode. Insertion of dopants also induces a polar deformation of neighboring host molecules, resulting in the creation of polar domains within the crystals...
April 20, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29676861/spatial-processes-decouple-management-from-objectives-in-a-heterogeneous-landscape-predator-control-as-a-case-study
#15
Peter J Mahoney, Julie K Young, Kent R Hersey, Randy T Larsen, Brock R McMillan, David C Stoner
Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model...
April 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29676853/miniaturized-matrix-solid-phase-dispersion-coupled-with-supramolecular-solvent-based-microextraction-for-the-determination-of-paraben-preservatives-in-cream-samples
#16
Elif Yıldız, Hasan Çabuk
An analytical method is presented for the determination of paraben preservatives in semi-solid cream samples by matrix solid-phase dispersion combined with supramolecular solvent-based microextraction. Due to the oily and sticky nature of the sample matrix, parabens were first extracted from the samples by matrix solid-phase dispersion using silica as sorbent material with a clean-up performed with tetrahydrofuran in the elution step. The eluate (500 μL), 1-decanol (120 μL) and water (4.4 mL) were then mixed in a polyethylene pipette to form supramolecular solvent...
April 20, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29676816/optimized-two-dimensional-gel-electrophoresis-in-an-alkaline-ph-range-improves-the-identification-of-intracellular-cfda-cisplatin-protein-adducts-in-ovarian-cancer-cells
#17
Sandra Kotz, Maximilian Kullmann, Ganna V Kalayda, Nadine Dyballa-Rukes, Ulrich Jaehde, Sabine Metzger
Intracellular binding of cisplatin to proteins has been associated with acquired resistance to chemotherapy. In our previous study we established an analytical method for the identification of intracellular cisplatin-binding proteins. The method used a fluorescent carboxyfluorescein-diacetate-labeled cisplatin analogue (CFDA-cisplatin), two-dimensional gel electrophoresis (2DE) and mass spectrometry, which allows detecting and identifying intracellular CFDA-cisplatin-containing protein adducts in the acidic pH range (pH 4-7)...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676811/determination-of-antidepressants-in-human-urine-extracted-by-magnetic-multiwalled-carbon-nanotube-poly-styrene-co-divinylbenzene-composites-and-separation-by-capillary-electrophoresis
#18
Khaled Murtada, Fernando de Andrés, Angel Ríos, Mohammed Zougagh
Poly(styrene-co-divinylbenzene)-coated magnetic multiwalled carbon nanotube composite synthesized by in-situ high temperature combination and precipitation polymerization of styrene-co-divinylbenzene has been employed as a magnetic sorbent for the solid phase extraction of antidepressants in human urine samples. Fluoxetine, venlafaxine, citalopram and sertraline were, afterwards, separated and determined by capillary electrophoresis with diode array detection. The presence of magnetic multiwalled carbon nanotubes in native poly(styrene-co-divinylbenzene) not only simplified sample treatment but also enhanced the adsorption efficiencies, obtaining extraction recoveries higher than 89...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676810/recent-trends-in-sorption-based-sample-preparation-and-liquid-chromatography-techniques-for-food-analysis
#19
Edvaldo V Soares Maciel, Ana Lúcia de Toffoli, Fernando Mauro Lanças
The accelerated rising of the world's population increased the consumption of food, thus demanding more rigors in the control of residue and contaminants in food-based products marketed for human consumption. In view of the complexity of most food matrices, including fruits, vegetables, different types of meat, beverages, among others, a sample preparation step is important to provide more reliable results when combined with high performance liquid chromatography separations. An adequate sample preparation step before the chromatographic analysis is mandatory in obtaining higher precision and accuracy in order to improve the extraction of the target analytes, one of the priorities in analytical chemistry...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676797/development-of-a-reversed-phase-liquid-chromatographic-method-for-analysis-of-pyridoxal-5-phosphate-and-its-impurities
#20
Marwa Fouad Mansour, Micheal Assefa, Ahmed El-Khouly, Peixi Zhu, Ann Van Schepdael, Erwin Adams
Since no proper method is available in literature for the analysis of pyridoxal-5'-phosphate, a reversed phase liquid chromatographic method was developed and validated for specificity, sensitivity, linearity, precision and accuracy. Nine potential related substances and forced degradation products could be successfully separated from the main peak. The separation was achieved on a Polaris C18 column (250 mm × 4.6 mm i.d., 5 μm) using a mobile phase consisting of 20 mM ammonium formate in 0.65 % formic acid - acetonitrile (98...
April 20, 2018: Electrophoresis
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