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Alekxander Popov, Zinaida K Blinnikova, Maria P Tsyurupa, Vadim A Davankov
New restricted access materials based on microporous hypercrosslinked polystyrene have been developed. The materials are aimed at the use as packings for solid-phase extraction cartridges to isolate low-molecular-weight analytes from biological fluids (for instance, blood plasma or serum). Two features distinguish these polymers from all known restricted access materials. The first one consists in that the microporous hypercrosslinked polystyrene not only exclude proteins from the sorbent phase but also do not adsorb them on the bead outer surface and so they do not cause coagulation of blood protein components...
June 21, 2018: Journal of Separation Science
Shih-Ming Tsai, Tyler Goshia, Yen-Chang Chen, Agnes Kagiri, Angelo Sibal, Meng-Hsuen Chiu, Anand Gadre, Vincent Tung, Wei-Chun Chin
The highly prevalent and virulent disease in the Western Hemisphere Coccidioidomycosis, also known as Valley Fever, can cause serious illness such as severe pneumonia with respiratory failure. It can also take on a disseminated form where the infection spreads throughout the body. Thus, a serious impetus exists to develop effective detection of the disease that can also operate in a rapid and high-throughput fashion. Here, we report the assembly of a highly sensitive biosensor using reduced graphene oxide (rGO) with Coccidioides(cocci) antibodies as the target analytes...
June 18, 2018: Colloids and Surfaces. B, Biointerfaces
Silvie Koval, Gregoire Krahenbuhl, Karryn Warren, Graham O'Brien
In urban environments airborne particulates (dust) must be managed to ensure that industry and community coexist in a mutually beneficial and sustainable manner. The composition of the dust is a function of the local environment and industry. In general, there is a view by many community members that a significant proportion of inhalable (PM10 ) and respirable (PM2.5 ) dust in these environments could be coal. Thus there is a need to have an analytical method that provides a quantitative analysis of the amount and size distribution of the different particulates that can be present in air samples...
June 18, 2018: Journal of Environmental Management
Liwen Cui, Xiaolei Xie, Zuojun Shen
There have been rapidly growing applications using machine learning models for predictive analytics in Electronic Health Records (EHR) to improve the quality of hospital services and the efficiency of healthcare resource utilization. A fundamental and crucial step in developing such models is to convert medical codes in EHR to feature vectors. These medical codes are used to represent diagnoses or procedures. Their vector representations have a tremendous impact on the performance of machine learning models...
June 18, 2018: Journal of Biomedical Informatics
Wei Gou, Zhen Jin
In this paper, an extended heterogeneous SIR model is proposed, which generalizes the heterogeneous mean-field theory. Different from the traditional heterogeneous mean-field model only taking into account the heterogeneity of degree, our model considers not only the heterogeneity of degree but also the heterogeneity of susceptibility and recovery rates. Then, we analytically study the basic reproductive number and the final epidemic size. Combining with numerical simulations, it is found that the basic reproductive number depends on the mean of distributions of susceptibility and disease course when both of them are independent...
August 2017: Infectious Disease Modelling
Jong-Il Kim, Min Soo Park, Tae-Gu Kim
Background: This research investigates the degrees of slipperiness felt by the participants who walk on contaminants applied to a floor surface to decide degrees of slipperiness for various contaminants. Methods: For the experiment, 30 participants walked on a floor to which six contaminants were applied. All participants took the analytic hierarchy process (AHP)-based slipperiness questionnaire survey for the six kinds of contaminants, and the results were compared with the coefficient of friction...
June 2018: Safety and Health At Work
Yasutaka Yamada, Takayuki Arai, Satoko Kojima, Sho Sugawara, Mayuko Kato, Atsushi Okato, Kazuto Yamazaki, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki
Recent studies revealed that some passenger strands of miRNAs acted as anti-tumor or oncogenic miRNAs in cancer cells. In this study, we focused on miR-455-5p (the passenger strand) and miR-455-3p (the guide strand) based on microRNA (miRNA) expression signatures of cancer cells. Both miR-455-5p and miR-455-3p were downregulated in renal cell carcinoma (RCC) tissues and low expression of these miRNAs was significantly associated with poor prognosis. Cancer cell proliferation, migration and invasive abilities were significantly inhibited by ectopic expression of miR-455-5p and miR-455-3p ...
June 1, 2018: Oncotarget
Rita Bettencourt-Silva, Josué Pereira, Sandra Belo, Daniela Magalhães, Joana Queirós, Davide Carvalho
Introduction: The diagnosis of pituitary carcinoma is very rare, requires the evidence of metastatic disease, and has a poor overall survival. Malignant prolactinoma frequently requires dopamine agonist therapy, pituitary surgery, radiotherapy, and even chemotherapy. Case description: A 19-year-old female presented with galactorrhea, primary amenorrhea, and left hemianopsia. Complementary study detected hyperprolactinemia and a pituitary macroadenoma with cavernous sinus invasion and suprasellar growth...
2018: Frontiers in Endocrinology
Linda J Skitka, Brittany E Hanson, Anthony N Washburn, Allison B Mueller
People often assume that moral and religious convictions are functionally the same thing. But are they? We report on 19 studies (N = 12,284) that tested whether people's perceptions that their attitudes are reflections of their moral and religious convictions across 30 different issues were functionally the same (the equivalence hypothesis) or different constructs (the distinct constructs hypothesis), and whether the relationship between these constructs was conditional on political orientation (the political asymmetry hypothesis)...
2018: PloS One
Alfonso Urzúa, Rodrigo Ferrer, Nidia Godoy, Francisca Leppes, Carlos Trujillo, Camila Osorio, Alejandra Caqueo-Urízar
The aim of the study is to analyze the mediating effect of self-esteem on the relationship between perceived discrimination and psychological well-being in South American immigrants in Chile. An analytical, cross sectional, non-experimental design was used. We evaluated 853 Peruvians and Colombians living in the northern cities of Arica, Antofagasta, and Santiago de Chile, the capital located in the center of the country. The instruments used were the Ryff Psychological Well-being Scale, the Rosenberg Self-Esteem Scale and the Perceived Discrimination Scale by Basabe, Paez, Aierdi and Jiménez-Aristizabal...
2018: PloS One
Alexander Kirpich, Elizabeth A Ainsworth, Jessica M Wedow, Jeremy R B Newman, George Michailidis, Lauren M McIntyre
In omics experiments, variable selection involves a large number of metabolites/ genes and a small number of samples (the n < p problem). The ultimate goal is often the identification of one, or a few features that are different among conditions- a biomarker. Complicating biomarker identification, the p variables often contain a correlation structure due to the biology of the experiment making identifying causal compounds from correlated compounds difficult. Additionally, there may be elements in the experimental design (blocks, batches) that introduce structure in the data...
2018: PloS One
Huabin Luo, Zhuo Adam Chen, Lei Xu, Ronny A Bell
OBJECTIVE: This study aimed to assess whether the recent Medicaid expansion, as a natural experiment, was associated with better access to care and, as a consequence, better receipt of clinical diabetes care services. METHODS: Data were from the Behavioral Risk Factor Surveillance System (BRFSS). The analytical sample included 20 708 working-age adults with diabetes aged 18 to 64 years from 22 states. The outcome variables included 4 measures of access to care and 4 measures of receipt of clinical diabetes care services...
June 20, 2018: Journal of Public Health Management and Practice: JPHMP
Jared Ament, Zhuo Yang, Bart Thaci, Edwin Kulubya, Wellington Hsu, Gerrit Bouma, Kee D Kim
STUDY DESIGN: Cost-utility analysis of an annular closure device (ACD) based on data from a prospective, multicenter randomized controlled trial (RCT) OBJECTIVE.: Determine the cost-effectiveness of a novel ACD in a patient population at high risk for recurrent herniation following discectomy SUMMARY OF BACKGROUND DATA.: Lumbar disc herniation patients with annular defect widths ≥ 6 mm are at high risk for recurrent herniation following limited discectomy. Recurrent herniation is associated with worse clinical outcomes and greater healthcare costs...
June 20, 2018: Spine
Jenny Harris, Katy Cheevers, Jo Armes
PURPOSE OF REVIEW: As rising numbers of people are living with the long-term impact of cancer, digital health is playing an increasingly important role in the monitoring and support of survivors and their caregivers. This article reviews current evidence, practice and developments, and identifies emerging issues and opportunities. RECENT FINDINGS: Digital health innovations, primarily using internet or smartphone-enabled applications, have been successfully developed, particularly in the areas of symptom management, decision-making, survivorship and follow-up care and palliative care...
June 20, 2018: Current Opinion in Supportive and Palliative Care
Alexandre Maes, Xavier Martinez, Karen Druart, Benoist Laurent, Sean Guégan, Christophe H Marchand, Stéphane D Lemaire, Marc Baaden
Proteomic and transcriptomic technologies resulted in massive biological datasets, their interpretation requiring sophisticated computational strategies. Efficient and intuitive real-time analysis remains challenging. We use proteomic data on 1417 proteins of the green microalga Chlamydomonas reinhardtii to investigate physicochemical parameters governing selectivity of three cysteine-based redox post translational modifications (PTM): glutathionylation (SSG), nitrosylation (SNO) and disulphide bonds (SS) reduced by thioredoxins...
June 21, 2018: Journal of Integrative Bioinformatics
Larry J Kricka
Predictions about the future of laboratory medicine have had a mixed success, and in some instances they have been overambitious and incorrectly assessed the future impact of emerging technologies. Current predictions suggest a more highly automated and connected future for diagnostic testing. The central laboratory of the future may be dominated by more robotics and more connectivity in order to take advantage of the benefits of the Internet of Things and artificial intelligence (AI)-based systems (e.g. decision support software and imaging analytics)...
June 21, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Muhammet Gul
The field of occupational health and safety (OHS) focuses on reducing occupational accidents to an acceptable level. OHS covers systematic efforts aimed at providing employee health, safety, and welfare in the workplaces. In this study, a new approach is proposed for risk assessment in the field of OHS. It integrates the Pythagorean fuzzy analytic hierarchy process (PFAHP) and the fuzzy VlseKriterijumska Optimizacija I Kompromisno Resenje (FVIKOR) into a risk assessment process. PFAHP is used in weighting the risk parameters...
June 21, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
David H Smith, Maureen O'Keeffe Rosetti, David M Mosen, A Gabriela Rosales, Erin Keast, Nancy Perrin, Adrianne C Feldstein, Theodore R Levin, Elizabeth G Liles
Colorectal cancer (CRC) causes more than 50,000 deaths each year in the United States but early detection through screening yields survival gains; those diagnosed with early stage disease have a 5-year survival greater than 90%, compared to 12% for those diagnosed with late stage disease. Using data from a large integrated health system, this study evaluates the cost-effectiveness of fecal immunochemical testing (FIT), a common CRC screening tool. A probabilistic decision-analytic model was used to examine the costs and outcomes of positive test results from a 1-FIT regimen compared with a 2-FIT regimen...
June 21, 2018: Population Health Management
Enoch F Sam, Justina Akansor, William Agyemang
This study explored street hawkers' lived experiences and risks in traffic using the phenomenological case study design. Data from 24 hawkers at three hawking spots and field observations form the basis of our study. A stratified purposeful sampling scheme was employed to ensure a balance of gender and age. Thematic data analytic strategy was employed in the data analysis. We found that participants' traffic incidents were mainly self-induced, attributable to their negligence on the road, indiscriminate road crossing and car-following behaviour...
June 21, 2018: International Journal of Injury Control and Safety Promotion
Jessica H Mirman, Brianne Roche, Ann Higgins-D'Alessandro
OBJECTIVE: The aims of this study were to extend the current literature on school climate that is focused on understanding how teacher, administrator, and student perceptions about driving-focused aspects of the social, educational, and institutional climate of schools can affect students' achievement, behavior, and adjustment towards the development of the concept of school safe driving climate (SSDC) and initiate the development of tools and processes for assessing SSDC. METHODS: A mixed-methods approach was used to develop an initial version of a survey-based measure of SSDC that involved self-report surveys (students) and in-depth interviews (teachers)...
June 21, 2018: Traffic Injury Prevention
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