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https://www.readbyqxmd.com/read/29454300/gold-copper-bimetallic-nanoparticles-supported-on-nano-p-zeolite-modified-carbon-paste-electrode-as-an-efficient-electrocatalyst-and-sensitive-sensor-for-determination-of-hydrazine
#1
Fatemeh Amiripour, Seyed Naser Azizi, Shahram Ghasemi
In this report, a facile, efficient and low cost electrochemical sensor based on bimetallic Au-Cu nanoparticles supported on P nanozeolite modified carbon paste electrode (Au-Cu/NPZ/CPE) was constructed and its efficiency for determination of hydrazine in trace level was studied. For this purpose, agro waste material, stem sweep ash (SSA) was employed as the starting material (silica source) for the synthesis of nano P zeolite (NPZ). After characterization of the synthesized NPZ by analytical instruments (scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy), construction of Au-Cu/NPZ/CPE was performed by three steps procedure involving preparation of nano P zeolite modified carbon paste electrode (NPZ/CPE), introducing Cu +2 ions into nano zeolite structure by ion exchange and electrochemical reduction of Cu +2 ions upon applying constant potential...
February 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29454105/assessing-the-repeatability-of-absolute-cmro-2-oef-and-haemodynamic-measurements-from-calibrated-fmri
#2
Alberto Merola, Michael A Germuska, Kevin Murphy, Richard G Wise
As energy metabolism in the brain is largely oxidative, the measurement of cerebral metabolic rate of oxygen consumption (CMRO 2 ) is a desirable biomarker for quantifying brain activity and tissue viability. Currently, PET techniques based on oxygen isotopes are the gold standard for obtaining whole brain CMRO 2 maps. Among MRI techniques that have been developed as an alternative are dual calibrated fMRI (dcFMRI) methods, which exploit simultaneous measurements of BOLD and ASL signals during a hypercapnic-hyperoxic experiment to modulate brain blood flow and oxygenation...
February 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29454104/functional-brain-connectivity-is-predictable-from-anatomic-network-s-laplacian-eigen-structure
#3
Farras Abdelnour, Michael Dayan, Orrin Devinsky, Thomas Thesen, Ashish Raj
How structural connectivity (SC) gives rise to functional connectivity (FC) is not fully understood. Here we mathematically derive a simple relationship between SC measured from diffusion tensor imaging, and FC from resting state fMRI. We establish that SC and FC are related via (structural) Laplacian spectra, whereby FC and SC share eigenvectors and their eigenvalues are exponentially related. This gives, for the first time, a simple and analytical relationship between the graph spectra of structural and functional networks...
February 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29453909/a-headspace-gas-chromatography-method-for-isopropanol-determination-in-warfarin-sodium-products-as-a-measure-of-drug-crystallinity
#4
Ziyaur Rahman, Sohail Akhtar, Akhtar Siddiqui, Anthony B Ciavarella, Agnes Nguyenpho, Patrick J Faustino, Mansoor A Khan
Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may change when the crystalline drug transforms to amorphous form. A headspace-gas chromatography (HS-GC) method was developed and validated for IPA determination in the WS drug product. n-propanol (NPA) was used as internal standard and the method was validated for specificity, system suitability, linearity, accuracy, precision, range, limits of detection and quantification, and robustness...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453895/cross-sectional-studies-what-are-they-good-for
#5
Ulrik Schiøler Kesmodel
Cross-sectional studies serve many purposes, and the cross-sectional design is the most relevant design when assessing the prevalence of disease, attitudes and knowledge among patients and health personnel, in validation studies comparing e.g. different measurement instruments, and in reliability studies. This paper describes the use and provides examples within obstetrics and gynecology. Caveats are also described; for example, when cross-sectional data is used for analytical purposes of associations between an exposure and an outcome, authors and readers should be careful not to make causal inferences, unless the exposure may safely be assumed to be stable over time and not influenced by experiencing the outcome...
February 17, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29453617/site-suitability-evaluation-of-an-old-operating-landfill-using-ahp-and-gis-techniques-and-integrated-hydrogeological-and-geophysical-surveys
#6
Masoud Saatsaz, Iman Monsef, Mostafa Rahmani, Abdolreza Ghods
Because of the outdated methods of common landfill selection, it is imperative to reevaluate the usage suitability. To assess the suitability of the existing waste landfill in Zanjan, Iran, we have used a combination of the analytical hierarchy process (AHP) and GIS techniques, along with fieldwork surveys. Four major criteria and 12 subcriteria were considered, and the AHP was applied to assign the relative importance weights of criteria and subcriteria to each other. Finally, a landfill suitability map was generated and ranked based on the final suitability scores...
February 16, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29453591/emotional-intelligence-empathy-and-alexithymia-in-anorexia-nervosa-during-adolescence
#7
Victoire Peres, Maurice Corcos, Marion Robin, Alexandra Pham-Scottez
PURPOSE: Socio-emotional difficulties have been observed on adult patients suffering from anorexia nervosa (AN). But researches with adolescents are scarce and non-congruent. The aim of this paper is to identify the socio-emotional difficulties that are encountered by AN during adolescence, and to isolate them from those encountered by control adolescents. METHOD: 41 AN and 38 control adolescents were assessed using the emotional quotient inventory by Bar-On, youth version (EQ-i: YV), the Toronto Alexithymia Questionnaire (TAS-20), the Interpersonal Reactivity Index (IRI), and anxiety and depression were controlled using the Hospital Anxiety and Depression Scale (HADS)...
February 16, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29453520/evaluation-of-a-comprehensive-oral-health-services-program-in-school-based-health-centers
#8
Tara Trudnak Fowler, Gregory Matthews, Cydny Black, Hendi Crosby Kowal, Pamella Vodicka, Elizabeth Edgerton
Objectives In 2011, the Maternal and Child Health Bureau, within the Health Resources and Services Administration, awarded a 4-year grant to increase access to and assure the delivery of quality oral health preventive and restorative services to children. The grant was awarded to organizations serving high-need communities through school-based health centers (SBHCs). This article describes an independent evaluation investigating program efficacy, integration, and sustainability. Methods Program process and outcomes data were gathered from interim and final reports...
February 16, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29453417/exome-sequencing-has-higher-diagnostic-yield-compared-to-simulated-disease-specific-panels-in-children-with-suspected-monogenic-disorders
#9
Oliver James Dillon, Sebastian Lunke, Zornitza Stark, Alison Yeung, Natalie Thorne, Clara Gaff, Susan M White, Tiong Yang Tan
As test costs decline, whole-exome sequencing (WES) has become increasingly used for clinical diagnosis, and now represents the primary alternative to gene panel testing for patients with a suspected genetic disorder. We sought to compare the diagnostic yield of singleton-WES with simulated application of commercial gene panels in children suspected of having a genetically heterogeneous condition. Recruitment, singleton-WES and phenotype-driven variant analysis was completed for 145 paediatric patients. At recruitment, clinicians were required to propose commercial gene panel tests as an alternative to WES and nominate a phenotype-driven candidate gene list...
February 16, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29453347/reversing-coffee-ring-effect-by-laser-induced-differential-evaporation
#10
Tony M Yen, Xin Fu, Tao Wei, Roshan U Nayak, Yuesong Shi, Yu-Hwa Lo
The coffee-ring effect, ubiquitously present in the drying process of aqueous droplets, impedes the performance of a myriad of applications involving precipitation of particle suspensions in evaporating liquids on solid surfaces, such as liquid biopsy combinational analysis, microarray fabrication, and ink-jet printing, to name a few. We invented the methodology of laser-induced differential evaporation to remove the coffee-ring effect. Without any additives to the liquid or any morphology modifications of the solid surface the liquid rests on, we have eliminated the coffee-ring effect by engineering the liquid evaporation profile with a CO 2 laser irradiating the apex of the droplets...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453295/socioeconomic-religious-spiritual-and-health-factors-associated-with-symptoms-of-common-mental-disorders-a-cross-sectional-secondary-analysis-of-data-from-bhutan-s-gross-national-happiness-study-2015
#11
Gyambo Sithey, Mu Li, Li Ming Wen, Patrick J Kelly, Kelly Clarke
OBJECTIVE: Common mental disorders (CMDs) are a major cause of the global burden of disease. Bhutan was the first country in the world to focus on happiness as a state policy; however, little is known about the prevalence and risk factors of CMDs in this setting. We aim to identify socioeconomic, religious, spiritual and health factors associated with symptoms of CMDs. DESIGN AND SETTING: We used data from Bhutan's 2015 Gross National Happiness (GNH) Survey, a multistage, cross-sectional nationwide household survey...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453257/a-facile-arsenazo-iii-based-assay-for-monitoring-rare-earth-element-depletion-from-cultivation-media-of-methanotrophic-and-methylotrophic-bacteria
#12
Carmen Hogendoorn, Paula Roszczenko-Jasińska, N Cecilia Martinez-Gomez, Johann de Graaff, Patrick Grassl, Arjan Pol, Huub J M Op den Camp, Lena J Daumann
Recently, methanotrophic and methylotrophic bacteria were found to utilize rare earth elements (REE). To monitor the REE-content in culture media of these bacteria we have developed a rapid screening method using the Arsenazo III (AS III) dye for spectrophotometric REE-detection in the low μM (0.1-10 μM) range. We designed this assay to follow La III and Eu III depletion from the culture medium by the acidophilic verrucomicrobial methanotroph Methylacidiphilum fumariolicum SolV. The assay can also be modified to screen the uptake of other REE such as Pr III or to monitor the depletion of La III from growth media in neutrophilic methylotrophs such as Methylobacterium extorquens AM1...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29453252/ecology-and-biotechnological-potential-of-bacteria-belonging-to-the-pseudovibrio-genus
#13
Stefano Romano
Bacteria belonging to the genus Pseudovibrio have been isolated worldwide from a great variety of marines sources as both free living and host associated. So far, the available data depict a group of Alphaproteobacteria characterized by a versatile metabolism, which allows them to use a variety of substrates to meet their carbon, nitrogen, sulfur, and phosphorous requirements. Additionally, Pseudovibrio -related bacteria have been shown to proliferate under extreme oligotrophic conditions, tolerate high heavy metal concentrations, and metabolize potentially toxic compounds...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29453194/comparison-of-generic-fluorescent-markers-for-detection-of-extracellular-vesicles-by-flow-cytometry
#14
Leonie de Rond, Edwin van der Pol, Chi M Hau, Zoltan Varga, Auguste Sturk, Ton G van Leeuwen, Rienk Nieuwland, Frank A W Coumans
BACKGROUND: Extracellular vesicles (EVs) in biofluids are potential biomarkers of disease. To explore the clinical relevance of EVs, a specific generic EV marker would be useful, one that does not require antibodies and binds to all EVs. Here we evaluated 5 commonly used generic markers for flow cytometry. METHODS: Flow cytometry (A60-Micro, Apogee) was used to evaluate the ability of the generic EV markers calcein acetoxymethyl ester, calcein acetoxymethyl ester violet, carboxyfluorescein succinimidyl ester (CFSE), 4-(2-[6-(dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium (di-8-ANEPPS), and lactadherin to stain EVs from MCF7 human breast adenocarcinoma cell line-conditioned culture medium [epithelial cell adhesion molecule positive (EpCAM + )] or platelet EVs from human plasma [integrin β3 positive (CD61 + )]...
February 16, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29453190/testing-behavior-change-techniques-to-encourage-primary-care-physicians-to-access-cancer-screening-audit-and-feedback-reports-protocol-for-a-factorial-randomized-experiment-of-email-content
#15
Gratianne Vaisson, Holly O Witteman, Zachary Bouck, Caroline A Bravo, Laura Desveaux, Diego Llovet, Justin Presseau, Marianne Saragosa, Monica Taljaard, Shama Umar, Jeremy M Grimshaw, Jill Tinmouth, Noah M Ivers
BACKGROUND: Cancer Care Ontario's Screening Activity Report (SAR) is an online audit and feedback tool designed to help primary care physicians in Ontario, Canada, identify patients who are overdue for cancer screening or have abnormal results requiring follow-up. Use of the SAR is associated with increased screening rates. To encourage SAR use, Cancer Care Ontario sends monthly emails to registered primary care physicians announcing that updated data are available. However, analytics reveal that 50% of email recipients do not open the email and less than 7% click the embedded link to log in to their report...
February 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29453097/self-assembled-vertically-aligned-au-nanorod-arrays-for-surface-enhanced-raman-scattering-sers-detection-of-cannabinol
#16
Sarah Milliken, Jeff Fraser, Shawn Poirier, John Hulse, Li-Lin Tay
Self-assembled multi-layered vertically aligned gold nanorod (AuNR) arrays have been fabricated by a simple preparation process that requires a balance between the particle concentration and the ionic strength of the solvent. An experimentally determined critical AuNR concentration of 2.0nM and 50mM NaCl produces well-ordered vertically aligned hexagonally close-packed AuNR arrays. We demonstrate surface treatment via UV Ozone cleaning of such samples to allow introduction of analyte molecules (benzenethiol and cannabinol) for effective surface enhanced Raman scattering detection...
January 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29453054/determining-the-number-of-contributors-to-dna-mixtures-in-the-low-template-regime-exploring-the-impacts-of-sampling-and-detection-effects
#17
Sarah Norsworthy, Desmond S Lun, Catherine M Grgicak
The interpretation of DNA evidence may rely upon the assumption that the forensic short tandem repeat (STR) profile is composed of multiple genotypes, or partial genotypes, originating from n contributors. In cases where the number of contributors (NOC) is in dispute, it may be justifiable to compute likelihood ratios that utilize different NOC parameters in the numerator and denominator, or present different likelihoods separately. Therefore, in this work, we evaluate the impact of allele dropout on estimating the NOC for simulated mixtures with up to six contributors in the presence or absence of a major contributor...
February 8, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29452859/evaluation-of-liquid-biopsies-for-detection-of-emerging-mutated-genes-in-metastatic-colorectal-cancer
#18
Hiroyasu Furuki, Takeshi Yamada, Goro Takahashi, Takuma Iwai, Michihiro Koizumi, Seiichi Shinji, Yasuyuki Yokoyama, Kohki Takeda, Nobuhiko Taniai, Eiji Uchida
BACKGROUND: Detection of gene mutations is important for planning molecular targeted therapy. Although most gene mutations are concordant between primary colon cancers and their liver metastases, new mutations can emerge in metastases. The liquid biopsy is a newly developed, gene analytic method to detect mutations in metastatic tumors. In this prospective study, we evaluated the applicability of liquid biopsies in the detection of mutations in primary and metastatic tumors. METHODS: We included 22 patients with liver metastases from colorectal cancer and extracted DNA from primary colorectal tumors, metastatic liver tumors, and peripheral blood (liquid biopsy)...
February 2, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29452766/traumatic-stress-and-accelerated-dna-methylation-age-a-meta-analysis
#19
Erika J Wolf, Hannah Maniates, Nicole Nugent, Adam X Maihofer, Don Armstrong, Andrew Ratanatharathorn, Allison E Ashley-Koch, Melanie Garrett, Nathan A Kimbrel, Adriana Lori, Va Mid-Atlantic Mirecc Workgroup, Allison E Aiello, Dewleen G Baker, Jean C Beckham, Marco P Boks, Sandro Galea, Elbert Geuze, Michael A Hauser, Ronald C Kessler, Karestan C Koenen, Mark W Miller, Kerry J Ressler, Victoria Risbrough, Bart P F Rutten, Murray B Stein, Robert J Ursano, Eric Vermetten, Christiaan H Vinkers, Monica Uddin, Alicia K Smith, Caroline M Nievergelt, Mark W Logue
BACKGROUND: Recent studies examining the association between posttraumatic stress disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of cellular age that exceed chronological age, have yielded mixed results. METHODS: We conducted a meta-analysis of trauma exposure and PTSD diagnosis and symptom severity in association with accelerated DNA methylation age using data from 9 cohorts contributing to the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (combined N = 2186)...
December 27, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29452583/does-rituximab-improve-clinical-outcomes-of-patients-with-thyroid-associated-ophthalmopathy-a-systematic-review-and-meta-analysis
#20
Changjun Wang, Qingyao Ning, Kai Jin, Jiajun Xie, Juan Ye
BACKGROUND: The current therapies of thyroid-associated ophthalmopathy (TAO) were still a challenging matter. In this study, we aimed to contrast the impact of before- after rituximab (RTX) therapy in the patients with TAO. METHODS: We searched the PubMed, EMBASE, and SCOPUS databases for articles published up to July 3, 2017. Fixed- or random-effects meta-analysis was used to provide pooled estimates of standard mean difference (SMD) both the primary outcome from clinical activity score (CAS), and secondary outcomes from thyrotropin receptor antibody (TRAb), proptosis, thyroid stimulating hormone (TSH), and interleukin-6 (IL-6) levels...
February 17, 2018: BMC Ophthalmology
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