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https://www.readbyqxmd.com/read/27916097/-effects-of-pyr-1-apelin-13-on-the-proliferation-and-activation-of-jarkat-t-lymphocyte
#1
Ming Wei, Lu Gan, Jin Hou, Lihong Chen, Yantong Liu, Ligang Ren
Objective To investigate the effect of (Pyr(1))apelin-13 on the proliferation and activation of Jurkat T lymphocytes. Methods Jurkat T cells were treated by 0, 10, 50 nmol/L (Pyr(1))apelin-13 for 24 hours and cell proliferation ability was detected by CCK-8 assay. The effect of (Pyr(1))apelin-13 on the activation of Jurkat T lymphocytes with anti-CD3 and anti-CD28 antibodies was observed and the molecular mechanism was investigated. Quantitative real-time PCR was applied to detect the expressions of CD69, CD25, cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) mRNAs...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27903222/sustained-elabela-gene-therapy-in-high-salt-induced-hypertensive-rats
#2
Claire A Schreiber, Sara J Holditch, Alex Generous, Yasuhiro Ikeda
BACKGROUND: Elabela (ELA) is a recently identified apelin receptor agonist essential for cardiac development, but its biology and therapeutic potential are unclear. In humans ELA transcripts are detected in embryonic stem cells, induced pluripotent stem cells, kidney, heart and blood vessels. ELA through the apelin receptor promotes angiogenesis in vitro, relaxes murine aortic blood vessels and attenuates high blood pressure in vivo. The apelin receptor when bound to its original ligand, apelin, exerts peripheral vasodilatory and positive inotropic effects, conferring cardioprotection in vivo...
November 21, 2016: Current Gene Therapy
https://www.readbyqxmd.com/read/27899856/effect-of-spironolactone-on-plasma-apelin-12-levels-in-patients-with-chronic-systolic-heart-failure
#3
Mustafa Topuz, Mehmet Cosgun, Oğuz Akkuş, Atilla Bulut, Omer Sen, Ayşe Nur Topuz, Murat Caylı
BACKGROUND: The aim of this study was to determine whether spironolactone therapy has an effect on serum apelin-12 levels in heart failure with reduced ejection fraction (HFrEF) patients. METHODS: Eighty outpatients previously diagnosed with HFrEF were enrolled in the current study. Included patients were taking only standard heart failure therapy (ST) (angiotensin converting enzyme or angiotensin receptor blocker, beta-blockers, loop diuretics and anticoagulant or antiagregan agents) without a mineralocorticoid receptor antagonists (MRA) because of its side effects, and were designated the non-MRA group; those patients taking 25 mg/daily spironolactone in addition to the ST were deemed the MRA group...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27894959/inhibition-of-the-apelin-apelin-receptor-axis-decreases-cholangiocarcinoma-growth
#4
Chad Hall, Laurent Ehrlich, Julie Venter, April O'Brien, Tori White, Tianhao Zhou, Tien Dang, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Terry Lairmore, Shannon Glaser
PURPOSE: Cholangiocarcinoma (CCA) is a malignancy of the biliary epithelium that is associated with low five-year survival. The apelin receptor (APLNR), which is activated by the apelin peptide, has not been studied in CCA. The purpose of this study is to determine if inhibition of the apelin/APLNR axis can inhibit CCA growth. METHODS: Immunohistochemistry, rtPCR, immunofluorescence, flow cytometry, and ELISA was used to measure APLNR expression in human CCA cells and tissues...
November 26, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27889567/prognostic-value-of-plasma-apelin-concentrations-at-admission-in-patients-with-st-segment-elevation-acute-myocardial-infarction
#5
Jordi Sans-Roselló, Gregori Casals, Xavier Rosselló, Bernardino González de la Presa, Montserrat Vila, Albert Duran-Cambra, Manuel Morales-Ruiz, Andreu Ferrero-Gregori, Wladimiro Jiménez, Alessandro Sionis
BACKGROUND: The use of plasma biomarkers is relevant for the prognosis of ST-segment elevation myocardial infarction (STEMI) patients. Apelin, an adipocytokine, plays a pivotal role in the pathophysiology of both ischemia/reperfusion injury and its potential subsequent heart failure. We evaluated apelin concentrations at admission as a biomarker to assess risk of 6-month mortality. METHODS: Consecutive patients with STEMI were recruited from January 2012 to January 2013 (n=250)...
November 23, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27863393/a-promoter-polymorphism-in-apj-gene-is-significantly-associated-with-blood-pressure-changes-and-hypertension-risk-in-chinese-women
#6
Guofeng Li, Xingyuan Sun, Dalong Zhao, Lan He, Lihong Zheng, Jing Xue, Bin Wang, Hongming Pan
The aim of this study was to interrogate the gender-specific association of 5 well-defined polymorphisms in apelin/APJ system with both blood pressure changes and hypertension risk in a northeastern Chinese population. This is a population-based case-control study, including 650 hypertensive patients and 645 normotensive controls. Data were analyzed by STATA and Haplo.Stats. The genotype distributions of 5 study polymorphisms were in Hardy-Weinberg equilibrium in both genders. The rs7119375 and rs10501367 were completely linked...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27854125/apelin-apj-system-a-novel-therapeutic-target-for-myocardial-ischemia-reperfusion-injury
#7
Zhe Chen, Di Wu, Lanfang Li, Linxi Chen
Apelin is the endogenous ligand of the G protein-coupled receptor, APJ. Recently, researches indicate that the apelin/APJ system involves in myocardial ischemia-reperfusion injury (MIRI), which is a common pathophysiological process in patients with heart diseases and therapies. The reperfusion induces the expression of apelin and APJ receptor, which play an important role in cardioprotection of MIRI. The apelin/APJ system alleviates MIRI mainly by decreasing mitochondrial reactive oxygen species and delaying the opening of mitochondrial permeability transition pores, which induce the initiation of mitophagy...
November 17, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27846147/apelin-regulates-nuclear-factor-%C3%AE%C2%BAb-s-involvement-in-the-inflammatory-response-of-pancreatitis
#8
Song Han, Ella W Englander, Guillermo A Gomez, George H Greeley
OBJECTIVES: Inflammation plays a key role in pancreatitis. Earlier studies from our laboratory showed that experimental pancreatitis activated the pancreatic apelin-APJ axis robustly in mice. Apelin signaling reduced neutrophil invasion and the activation of pancreatic nuclear factor (NF)-κB in mice with experimental pancreatitis. METHODS: The aim of this study was to assess whether apelin-induced inhibition of pancreatic NF-κB activation was linked mechanistically to apelin's inhibition of pancreatic inflammatory mediator up-regulation in mice with cerulein-induced chronic pancreatitis (CP)...
November 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27834140/hypoxic-exercise-training-promotes-apelin-apj-expression-in-skeletal-muscles-of-high-fat-diet-induced-obese-mice
#9
Weixiu Ji, Lijing Gong, Jianxiong Wang, Hui He, Ying Zhang
Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is a novel myokine and may play a key role in regulating energy metabolism. The purpose of the present study was to investigate the effects of hypoxic exposure, exercise, and hypoxic exercise training on the expression of apelin and APJ in skeletal muscle of obese mice. 60 two-month old C57BL/6J mice were randomly divided into two groups: 10 in normal diet group (N) and 50 in the high fat diet (HFD) groups. After two months of feeding, the HFD mice whose body weight 20% higher than the average weight of N group were selected as obese mice and were further allocated into four groups: Control (C), Exercise (E), Hypoxia (H), and Exercise plus Hypoxia (E+H), at 8-9 mice/group...
November 11, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27831922/the-association-between-single-nucleotide-polymorphisms-of-the-apelin-gene-and-diabetes-mellitus-in-a-chinese-population
#10
Hui Zheng, Xiaofang Fan, Xuesong Li, Yu Zhang, Yujuan Fan, Ning Zhang, Yuping Song, Fengdong Ren, Chunfang Shen, Jiayi Shen, Jialin Yang
BACKGROUND: The objective of the study was to analyze the association of apelin gene (APLN) single nucleotide polymorphisms (SNPs) and type 2 diabetes mellitus (T2DM). METHODS: A total of 1966 subjects were enrolled in this study, including 168 cases (first batch), 330 cases (second batch), and 1468 nondiabetic controls. The SNPs in the HapMap-HCB of APLN were detected using Sequenom MassARRAY SNP technology and included rs2281068, rs3115757, rs2235309, and rs2235310...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27828952/computational-screening-of-tip-and-stalk-cell-behavior-proposes-a-role-for-apelin-signaling-in-sprout-progression
#11
Margriet M Palm, Marchien G Dallinga, Erik van Dijk, Ingeborg Klaassen, Reinier O Schlingemann, Roeland M H Merks
Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an endothelial cell type that forms the body of the sprout. To get more insight into how tip cells contribute to angiogenesis, we extended an existing computational model of vascular network formation based on the cellular Potts model with tip and stalk differentiation, without making a priori assumptions about the differences between tip cells and stalk cells...
2016: PloS One
https://www.readbyqxmd.com/read/27825851/targeting-the-apelin-pathway-as-a-novel-therapeutic-approach-for-cardiovascular-diseases
#12
Jiu-Chang Zhong, Zhen-Zhou Zhang, Wang Wang, Shaun M K McKinnie, John C Vederas, Gavin Y Oudit
The apelin/apelin receptor system is widely distributed and has a dominant role in cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as a 77 amino acid pre-pro-peptide that is subsequently cleaved to generate a family of apelin peptides that possess similar functions but display different tissue distribution, potency and receptor binding affinity. Loss-of-function experiments using the apelin and the apelin receptor knockout mice and gain-of-function experiments using apelin peptides have delineated a well-defined role of the apelin axis in cardiovascular physiology and diseases...
November 4, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27815337/development-of-original-metabolically-stable-apelin-17-analogs-with-diuretic-and-cardiovascular-effects
#13
Romain Gerbier, Rodrigo Alvear-Perez, Jean-Francois Margathe, Adrien Flahault, Pierre Couvineau, Ji Gao, Nadia De Mota, Hubert Dabire, Bo Li, Emilie Ceraudo, Annette Hus-Citharel, Lucie Esteoulle, Cynthia Bisoo, Marcel Hibert, Alain Berdeaux, Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortes
Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling cardiovascular functions and water balance. Because the in vivo apelin half-life is in the minute range, we aimed to identify metabolically stable apelin-17 (K17F) analogs. We generated P92 by classic chemical substitutions and LIT01-196 by original addition of a fluorocarbon chain to the N terminus of K17F. Both analogs were much more stable in plasma (half-life >24 h for LIT01-196) than K17F (4.6 min). Analogs displayed a subnanomolar affinity for the apelin receptor and behaved as full agonists with regard to cAMP production, ERK phosphorylation, and apelin receptor internalization...
November 4, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27797720/apelin-receptor-signaling-a-novel-mechanism-of-endothelial-cell-polarization
#14
Hong Zhao, Pingbo Yao, Lanfang Li, Linxi Chen
No abstract text is available yet for this article.
December 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27784688/high-intensity-interval-training-but-not-continuous-training-reverses-right-ventricular-hypertrophy-and-dysfunction-in-a-rat-model-of-pulmonary-hypertension
#15
Mary Beth Brown, Evandro Neves, Gary Marshall Long, Jeremy Bryce Graber, Brett Alexandria Gladish, Andrew Wiseman, Matthew Owens, Amanda Jo Fisher, Robert Gray Presson, Irina Petrache, Jeffrey A Kline, Tim Lahm
BACKGROUND: Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive RV hypertrophy associated with the disease. For chronic LV failure, high intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs...
October 26, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27776716/assessment-of-apelin-serum-levels-in-persistent-atrial-fibrillation-and-coronary-artery-disease
#16
Mehrnaz Riazian, Elnaz Khorrami, Elham Alipoor, Sina Moradmand, Mehdi Yaseri, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND: Apelin, the endogenous ligand of orphan receptor APJ (gene symbol APLNR), is an adipokine that was suggested to have a direct correlation with obesity. This peptide might play a role in obesity-related disorders, especially in the cardiovascular system. Currently, few data are available on levels and potential metabolic functions of apelin in different cardiac diseases including atrial fibrillation (AF) and coronary artery disease (CAD), which have common underlying pathophysiological mechanisms...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27773659/ascending-aortic-adventitial-remodeling-and-fibrosis-are-ameliorated-with-apelin-13-in-rats-after-tac-via-suppression-of-the-mirna-122-and-lgr4-%C3%AE-catenin-signaling
#17
Ran Xu, Zhen-Zhou Zhang, Lai-Jiang Chen, Hui-Min Yu, Shu-Jie Guo, Ying-Le Xu, Gavin Y Oudit, Yan Zhang, Qing Chang, Bei Song, Dong-Rui Chen, Ding-Liang Zhu, Jiu-Chang Zhong
Apelin has been proved to be a critical mediator of vascular function and homeostasis. Here, we investigated roles of Apelin in aortic remodeling and fibrosis in rats with transverse aortic constriction (TAC). Male Sprague-Dawley rats were subjected to TAC and then randomized to daily deliver Apelin-13 (50μg/kg) or angiotensin type 1 receptor (AT1) blocker Irbesartan (50mg/kg) for 4 weeks. Pressure overload resulted in myocardial hypertrophy, systolic dysfunction, aortic remodeling and adventitial fibrosis with reduced levels of Apelin in ascending aortas of rat after TAC compared with sham-operated group...
December 2016: Peptides
https://www.readbyqxmd.com/read/27770057/plasma-apelin-12-levels-may-predict-in-hospital-major-adverse-cardiac-events-in-st-elevation-myocardial-infarction-and-the-relationship-between-apelin-12-and-the-neutrophil-lymphocyte-ratio-in-patients-undergoing-primary-coronary-intervention
#18
Mustafa Topuz, Fahrettin Oz, Oguz Akkus, Omer Sen, Ayse Nur Topuz, Atilla Bulut, Suleyman Ozbicer, Sefa Okar, Mevlut Koc, Mustafa Gur
OBJECTIVE: We aimed to investigate the compliance of plasma apelin-12 levels to show angiographic properties and hospital MACE in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). MATERIAL AND METHODS: The association of apelin-12 levels with the N/L ratio on admission was assessed in 170 consecutive patients with primary STEMI undergoing primary PCI. All patient SYNTAX scores and thrombolysis in myocardial infarction (TIMI) flow grades were also assessed...
October 20, 2016: Perfusion
https://www.readbyqxmd.com/read/27754275/sy-18-1-translational-research-in-pah
#19
Wook-Jin Chung
Pulmonary arterial hypertension (PAH) is a life-threatening disorder with a poor prognosis and causes pulmonary vascular remodeling accompanied with increased pulmonary arterial medial wall thickness and fibrosis, which leads to vascular and right ventricular (RV) dysfunction. Despite treatment with prostacyclin, endothelin antagonist, and phosphodiesterase-5 inhibitors the 1-year mortality rate of PAH still remains high. Recent registries, clinical trials, and basic researches have been increasing the knowledge of PAH and it would contribute to potential therapeutic strategies and better clinical outcome...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754256/os-36-07-treatment-with-apelin-13-prevents-pressure-overload-induced-aortic-adventitial-remodeling-and-fibrosis-in-hypertensive-rats-with-tac
#20
Jiu-Chang Zhong, Zhen-Zhou Zhang, Ran Xu, Lai-Jiang Chen, Shu-Jie Guo, Ying-Le Xu, Gavin Oudit, Hai-Yan Jin, Bei Song, Qing Chang, Ping-Jin Gao, Ji-Guang Wang
OBJECTIVE: The Apelin/APJ system has recently been implicated in pathologies of hypertension. However, little was elucidated upon effects of Apelin on vascular adventitial remodeling progression. Here, we examined regulatory roles of Apelin in pressure overload-induced adventitial remodeling and fibrosis in hypertensive rats. DESIGN AND METHOD: The male Sprague-Dawley rats were performed with transverse aortic constriction (TAC). The rats with TAC were randomized to daily deliver either pyroglutamyl Apelin-13 (50 μg/kg) or saline for 4 weeks...
September 2016: Journal of Hypertension
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